New study shows no effect of low-dose intraoperative ketamine on delirium

Use of low-dose intraoperative ketamine does not lower levels of postoperative pain or reduce delirium in older adults undergoing surgery, according to a new study led by Michael Avidan, MBBCh, Professor of Anesthesiology and Surgery at Washington University St. Louis and NIDUS co-investigator. The findings from this multi-site randomized trial were published online on May 30 […]

Two clasped hands

Interaction of Delirium and Dementia on Cognitive Decline

The differences between delirium and dementia can be difficult to spot. If an elderly man with Alzheimer’s disease tends to become confused or agitated in the evening (a condition often known as “sundowning”¹) is his behavior dementia- or delirium-related? Moreover, what are the biological bases that differ between delirium and dementia? New research published in […]

3 people in surgical scrubs surround an operating room table.

Connectivity and Plasticity: Two factors that may influence cognitive decline after delirium

Delirium¹ – a serious disturbance in mental abilities that results in confused thinking and reduced awareness of the environment – is a costly and common condition. Though delirium can affect anyone, it is most prevalent in the elderly, affecting up to 50% of hospitalized seniors. However, it is not yet known why some individuals develop […]

The NIDUS Blog: Introduction and Overview

Welcome to the NIDUS Blog!The NIDUS Blog is led by the NIDUS Dissemination Task Force leaders, Andrew Auerbach, MD, University of California San Francisco, and Jan Busby-Whitehead, MD, University of North Carolina.The goals of this blog are two-fold. First, we hope to provide informative and thought-provoking posts about delirium research, treatment, experiences and more. Second, […]