Phillipe E. Vlisides, MD

Perioperative Neurocognitive Disorders and Putative Biomarkers

Contributed by Phillipe E. Vlisides, MD, Department of Anesthesiology, University of Michigan Medicine, Ann Arbor, MI Background Perioperative neurocognitive disorders represent a major public health issue, particularly among aging surgical populations. In fact, the American Society of Anesthesiologists has launched a Brain Health Initiative with the aim of protecting and preserving brain health in older […]

Fienke L. Ditzel, MD; Arjen J. C. Slooter MD, PhD; Suzanne C.A. Hut, PhD

The Delirium Interview: a new reference standard for large studies evaluating delirium assessment tools

Contributed by Fienke L. Ditzel, MD; Arjen J. C. Slooter MD, PhD; and Suzanne C.A. Hut, PhD, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands Rationale The gold standard for diagnosing delirium is the classification by a delirium expert based on the DSM-5(TR) criteria.1,2 When validating a new delirium assessment tool, ideally, a panel […]

Nadia Lunardi, MD, PhD

Sleep Fragmentation, EEG Slowing and Circadian Disarray in a Mouse Model for Intensive Care Unit Delirium

Contributed by Nadia Lunardi, M.D., Ph.D., Associate Professor of Anesthesiology and Critical Care, University of Virginia and Michal Jedrusiak, M.D., Visiting Graduate Student, Anesthesiology Department, University of Virginia Introduction In 2020, our research group introduced a novel mouse model designed to investigate postoperative delirium.1 This model aimed to emulate the combination of surgical stress, anesthetic […]

Dr Tamara Fong

Expanding delirium prevention during COVID-19 with the Modified and Expanded Hospital Elder Life Program (HELP-ME)

Contributed by Tamara G. Fong, MD PhD, Associate Professor of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, and Hebrew SeniorLife, Boston, MA USA; Jason Albaum, Vassar College, USA; and Sharon K. Inouye, MD MPH, Milton and Shirley F. Levy Family Chair and Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, […]

Oluwaseun Johnson-Akeju, MD

Postoperative Delirium and Long-Term Subjective Cognitive Decline After Cardiac Surgery

Contributed by Oluwaseun Johnson-Akeju, MD, Anesthetist-in-Chief at Massachusetts General Hospital and Henry Isaiah Dorr Associate Professor of Research and Teaching in Anaesthetics and Anaesthesia at Harvard Medical School, and Ariel Mueller, MA, Administrative Director for Research in the Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital on behalf of the Minimizing […]

Gen Shinozaki, MD

Can Delirium Assessment with Bispectral EEG (BSEEG) Help Predict Patient Outcome(s)?

Contributed by Gen Shinozaki, MD, Associate Professor of Psychiatry and Behavioral Health, Stanford University School of Medicine, Palo Alto, CA The Shinozaki Lab at Stanford University, previously at the University of Iowa, has been working to develop a novel portable EEG device to help detect delirium in hopes it will improve patient outcome(s). This bispectral […]

UB-CAM QR code for downloading iPhone app

Update on the Ultra-Brief Confusion Assessment Method (UB-CAM)

Contributed by Edward R. Marcantonio MD, MSc, Professor of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School and Donna M. Fick, RN, PhD, Director of the Center of Geriatric Nursing Excellence, Penn State In 2020, we wrote a NIDUS blog introducing the Ultra-Brief Confusion Assessment Method (UB-CAM) 1, an ultra-brief, adaptive tool for assessing […]

Zachary Kunicki, PhD

The Trajectory of Cognitive Aging after Experiencing Postoperative Delirium

Contributed by Zachary Kunicki, PhD, Assistant Professor of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA; Richard Jones, PhD, Professor of Psychiatry and Human Behavior and Neurology, Warren Alpert Medical School of Brown University, Providence, RI, USA; and Sharon Inouye, MD MPH, Milton and Shirley F. Levy Family Chair […]

Flavia Barreto Garcez MD, PhD

The potential association between gut microbiota and delirium in acutely ill older adults: an important area for further investigation

Contributed by Flavia Barreto Garcez MD, PhD and Thiago Junqueira Avelino-Silva, MD, PhD Laboratorio de Investigacao Medica em Envelhecimento (LIM 66), Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazil The gut microbiota, the collection of microorganisms in our gastrointestinal tract,1 has gained increasing attention in recent years. It […]

The NIDUS Delirium Research Hub: 10 Questions

Recently, Dr. Ed Marcantonio, NIDUS Delirium Research Hub Leader, created a list of 10 Questions about the NIDUS Delirium Research Hub. Below is a preview of the list: 1) What is the NIDUS Delirium Research Hub? The Delirium Research Hub, one of five NIDUS cores, is a repository of meta-data (like a “table of contents”) […]