News and Announcements

This page includes all NIDUS announcements, updates and news. We will also feature a new article from the Hospital Elder Life Program Delirium Bibliography each month on this page.

Living in disadvantaged neighborhoods doubles post-op delirium risk for older adults

A new study by Dr. Franchesca Arias and Dr. Sharon Inouye showed older adults who live in the most disadvantaged neighborhoods are two times more likely to experience delirium after surgery than their counterparts from more affluent communities. Read the full press release here.

Congratulations NIDUS Year 5 Pilot Grant Awardees! 

The NIDUS Pilots and Innovation Task Force announces two new pilot grants to advance innovation in delirium research. The goal is to provide funding for investigation into innovative areas of delirium research and support research on priority areas. From a pool of over 40 applications, these two grants have been selected for funding during Year 5.

NIDUS is thrilled to partner with a new group of researchers to further the field of delirium research. We look forward to sharing news about their studies and outcomes.

Joseph Hippensteel, MD | University of Colorado
Potentiation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) by highly-sulfated chondroitin sulfate: a novel contributor to sepsis-associated delirium

Kimberly Oosterhouse, PhD | Loyola University Chicago 
Computable Phenotyping of Delirium: Analyzing the Unstructured Data

Mobility Action Group: Using Quality Improvement Methods to Create a Culture of Hospital Mobility

The Mobility Action Group (MACT) and Change Package were developed to provide a conceptual framework, road map, and step‐by‐step guide to enable mobility teams to implement mobility programs successfully and meet their mobilization goals. The MACT and Chage Package provides an innovative approach emphasizing system wide change that can help catalyze a culture of mobility in hospitals across the nation, improving the quality of care for hospitalized older adults. Read the full article here.

Congratulations NIDUS Year 4 Pilot Grant Awardees!

The NIDUS Pilots and Innovation Task Force announces four new pilot grants to advance innovation in delirium research. The goal is to provide funding for investigation into innovative areas of delirium research and support research on priority areas. From a pool of over 40 applications, these four grants have been selected for funding during Year 4.

NIDUS is thrilled to partner with a new group of researchers to further the field of delirium research. We look forward to sharing news about their studies and outcomes.

Sean Barnes, MD | Johns Hopkins School of Medicine 
Neurofunctional Outcomes and Biomarkers of Postoperative Delirium in Children after Cardiac Bypass Surgery

Sangil Lee, MD | University of Iowa Carver College of Medicine
Machine Learning Algorithm to Predict Delirium from Emergency Department Data

Michael Reznik, MD | Brown University
Validating the Fluctuating Mental Status Evaluation: A Novel Delirium Screening Tool for Critically Ill Patients with Stroke

Ravikanth Velagapudi, PhD | Duke University
Profiling Postoperative Neuroinflammation in a Mouse Model of Delirium Superimposed on Parkinson’s Disease

Delirium An Under Diagnosed Area Of Brain Aging And Degeneration, Podcast with Dr. Sharon Inouye

"Most shockingly, delirium is often unrecognized. Studies have shown that in affected persons, that delirium is only recognized by about 1/3 of physicians and nurses."

Listen or watch the conversation.

Joining Forces against Delirium — From Organ-System Care to Whole-Human Care By Sharon K. Inouye

"Rather than designating delirium as a “never event” for hospitals, Medicare could offer incentives for the use of proven strategies for preventing it — such as ensuring early mobility, reducing use of bed or chair alarms, minimizing use of psychoactive drugs, and providing adaptations for vision and hearing impairment — in order to motivate change."

Read more from Dr. Inouye's NEJM Perspectives piece here: https://www.nejm.org/doi/full/10.1056/NEJMp1910499

 

 

The NIDUS Delirium Research Hub has now been listed as one of the NIH's Open Domain-Specific Data Sharing Repositories! Make sure to submit your delirium study to the Hub!

Bereavement Care in America is Broken: A Call to Action By Joyal Mulheron, Sharon K. Inouye

The death of a child, at any age, is one of the most – if not the most – stressful life events a person can go through. Bereavement is associated with severe health, social, and economic consequences – but sparse legal and social supports exist to protect grieving parents.

The authors of the newest NAM Perspectives commentary state that bereavement care in the United States is broken, and call for evidence-based research into the prevalence and outcomes of bereavement and how to best mitigate the adverse short- and long-term outcomes of coping with bereavement. The authors believe there is much that can be done to address this crisis, and that it must be approached with sensitivity and attention as we care for those who have experienced the profound loss of a child. Read more: https://doi.org/10.31478/202001e

New Wall Street Journal article featuring Dr. Sharon Inouye and Dr. Wes Ely out now! Read more about the ways to combat delirium here.

New Randomized Clinical Trial Demonstrates Effectiveness of Adapted Hospital Elder Life Program

A new randomized controlled trial in JAMA Internal Medicine has demonstrated the effectiveness of the Hospital Elder Life Program (HELP), this time in an adapted, tailored format. The HELP Program reduces delirium and functional decline in hospitalized older adults through daily interventions, many of which are performed by volunteers.

This study enrolled 281 surgical patients at a hospital in China and compared a group receiving a tailored version of the HELP program (t-HELP) to a group receiving usual care with no HELP program. T-HELP included non-pharmacological interventions completed by family members (instead of volunteers) trained by nursing staff. Results demonstrated the effectiveness of this t-HELP format, as occurrence of delirium was only 2.6% in the t-HELP group while 19.4% in the usual care group. And even further, patients who received t-HELP program had greater recovery (both cognitive and functional) one month after surgery compared to the usual care group.

This is a very important study, as in China, family members are frequently involved in care of older persons but hospitals often do not utilize volunteers. This study demonstrates that HELP can be adapted to fit a variety of institutional formats. Read more about the study here: https://scienmag.com/family-members-can-assist-in-preventing-post-operative-delirium-by-as-much-as-16-8/ 

Dr. Inouye's interview, "Delirium, Dementia, and the Brain", is featured in The Harvard Mahoney Neuroscience Institute Letter!

Delirium Research Hub Investigator Spotlight: Eyal Kimchi

Every other month, the Delirium Research Hub selects an investigator and research study included in the Delirium Research Hub to feature as a Spotlight Investigator. This month, we are featuring Dr. Eyal Kimchi, MD, PhD for his study “Massachusetts General Hospital (MGH) Delirium Electroencephalography (EEG) Study.” This study investigates EEGs, a promising biomarker that has […]

Possible role for the CNS arousal network in delirium

Contributed by Olga Boukrina, Ph.D., Kessler Foundation Delirium is a multicomponent syndrome produced by a set of unique vulnerabilities (e.g., infection, advanced age, decreased cognitive functioning) and compounding causes (e.g., circadian dysregulation, oxidative stress, neuronal aging). The contribution of each individual factor and their interactions present a complicated picture, but unifying themes in this line […]

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Delirium Research Hub Investigator Spotlight: Olga Boukrina

Every other month, the Delirium Research Hub selects an investigator and research study included in the Delirium Research Hub to feature as a Spotlight Investigator. This month, we are featuring Dr. Olga Boukrina, PhD, for her study “Neglect and Delirium,” which investigates a potential neural mechanism underlying the link between delirium and spatial neglect in […]

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Delirium Research Hub Investigator Spotlight: Chris Hughes

Every other month, the Delirium Research Hub selects an investigator and research study included in the Delirium Research Hub to feature as a Spotlight Investigator. This month, we are featuring Dr. Chris Hughes, MD, for his study “Role of Endothelial and Brain Injury in Acute and Long-term Brain Dysfunction,” which observed that higher levels of […]

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Delirium Research Hub Investigator Spotlight: Tanya Mailhot

Each month, the Delirium Research Hub selects an investigator and research study included in the Delirium Research Hub to feature as a Spotlight Investigator. This month, we are featuring Dr. Tanya Mailhot, PhD, RN for her study, “Evaluation of a Nurse Mentoring Intervention with Family Caregivers in the Management of Delirium (MENTOR_D)” which piloted a […]