This page includes all NIDUS announcements, updates and news. We will also feature a new article from the Delirium Bibliography each month on this page.
Delirium Central is Live!
Delirium Central is a newly-launched, delirium-focused website. Maintained by Dr. Sharon K. Inouye and the Aging Brain Center team at the Marcus Institute for Aging Research, a Harvard Medical School affiliate, the site offers delirium resources for clinicians, researchers, patients, and family members. In addition, the site cross-links with NIDUS II.
Delirium Central's vision is promoting a world where delirium prevention and healthy brain aging are realities for all. The major goals of this new initiative is "to inspire and engage the medical and research community to address issues of delirium and healthy brain aging as global priorities."
Explore Delirium Central today.
The National Institute on Aging/American Geriatrics Society (NIA/AGS) Webinar for Early Career Researchers
Registration is Now Open! The National Institute on Aging/American Geriatrics Society (NIA/AGS) Webinar for Early Career Researchers is being held Thursday, June 30 from 1:00 – 2:30 pm ET. For early career researchers and anyone else who would like to attend, NIA representatives will provide an overview of the various divisions within NIA and available opportunities for funding. Along with a Q&A session and breakouts, you won’t want to miss this. Click here to view the agenda.
Application Now Available for Joint AGS/NIA Conference – Overview of the Resilience World – State of Science
We are excited to announce that the first R13 Bench-to-Bedside conference in a three-part series, “Overview of the Resilience World – State of Science,” will be held at the Fairmont Hotel in Washington, DC from Wednesday, October 12 to Thursday, October 13, 2022. Sponsored by the National Institute on Aging (NIA) and the American Geriatrics Society (AGS), this conference will provide attendees with a broad overview of resilience and set the stage for the remaining two conferences in the series. The primary focus will be to explore areas of commonalities and differences with respect to the conceptual frameworks and research approaches for physical, cognitive, and psychosocial domains of resilience. Click here to view the preliminary agenda.
Apply to attend by TUESDAY, JULY 5, 2022!
Butler-Williams Scholar Program
The National Institute on Aging Butler-Williams Scholars Program is accepting applications for their 2022 cohort now.
The Butler-Williams (B-W) Scholars Program provides a powerful pathway for early-career scientists to expand their networks, advance grant writing skills, and gain a broader understanding of the science NIA conducts and supports. Early Career Scientists who are new to the field of aging may gain more knowledge about aging research as well as health disparities research in aging. It includes scientific presentations and small group activities related to the life course of aging, including: the biology of aging; genetics and Alzheimer's disease; and health, behavior, and aging.
Researchers from diverse backgrounds, with disabilities and/or who have an interest in health disparities research are encouraged to apply.
Application details can be found here. Applications are due April 15, 2022.
For more information about the program’s benefits, check out this post from the NIA Blog.
Call for Applications for the 2022-2023 Class of Health and Aging Policy Fellows
Are you committed to improving health and aging? Are you interested in learning about policymaking to increase your impact?
If so, we invite you to apply to join the next class of Health and Aging Policy Fellows!
As a Health and Aging Policy Fellow, you have the opportunity to join a dynamic community of 166 Fellows who are committed to improving health and quality of life for older Americans.
The one-year Fellowship runs from October 1 – September 30 and has full-time and part-time tracks. It is conducted as a hybrid program of mentoring, networking, learning and practicum experiences. Health and Aging Policy Fellows work across diverse fields of aging. They develop lifelong partnerships and networks. Individually and collectively they are improving the lives of older adults around the country.
2022 Cycle of NAM Healthy Longevity Catalyst Awards
As part of the Healthy Longevity Global Competition, the National Academy of Medicine (NAM) is accepting applications for the 2022 cycle of its U.S.-based Catalyst Awards. Applications will be accepted from January 17, 2022, through February 28, 2022, at 11:59 pm EST. Up to 25 innovators will each receive a cash prize of $50,000 plus travel costs to attend the annual Global Innovator Summit in 2023.
To help address the world’s rapidly aging population, the NAM launched the Healthy Longevity Global Competition: a three-phase awards program designed to identify and support bold, innovative, and potentially breakthrough ideas to improve health as people age. The Catalyst Awards reward exciting new or early-stage projects that have the potential to advance the field of healthy longevity and extend the human healthspan—in turn allowing individuals to live more enriching lives and stay active in their communities, families, and the workforce well into their later years.
Eligible projects aim to improve the mental, physical, or social health and well-being of individuals and can focus on any stage of life, as long as they ultimately promote health for people as they age.
US-based individuals and teams from all fields, backgrounds, industries, and specialties are encouraged to complete the simple 2-page application to be considered for a $50,000 prize. In addition to the winners, all applicants advancing to the final stages of the Catalyst Award review process are automatically considered for subsequent funding in the form of an Accelerator Award, the second phase of the Global Competition, worth $150,000 to more than $1 million USD.
For inspiration, check out the winners of the previous rounds of NAM Catalyst Awards, who have backgrounds in public service, computer science, clinical medicine, biomedical research, public health, and more.
To learn more, check out our 2021 informational webinar for prospective applicants, guidelines for submission, and our FAQ. For any other questions, please contact email@example.com with the subject line “Question – NAM Catalyst Awards.”
The NAM’s US-based Catalyst Award competition is part of a global initiative to extend the human healthspan. There are a number of Catalyst Award competitions worldwide that are open to innovators in over 50 countries and territories!
Apply today for a chance to share your innovative idea with the world – and transform the future of aging!
Boost your career with the Butler-Williams Scholars Program
Give your career the Butler-Williams boost this summer!
Patricia Jones, Director, Office of Special Populations
Attention early-stage investigators and junior faculty: Would you like to take your aging research career to the next level? The NIA Butler-Williams Scholars Program provides powerful pathways to expand networks, advance grant writing skills, and gain a broader understanding of NIA science.
The 2022 Butler-Williams Scholars Program will be held virtually August 23-25, and the application deadline is April 15. Read the full blog post.
NIDUS Bibliography is updated with over 70 new manuscripts
Visit NIDUS Bibliography at https://deliriumnetwork.org/bibliography/
NIDUS article of the month
Effect of aWard-Based Program on Hospital-Associated Complications and Length of Stay for Older Inpatients The Cluster Randomized CHERISH Trial
Alison M. Mudge, MBBS, PhD; Prue McRae, BPhty, MPhil; Merrilyn Banks, PhD; Irene Blackberry, PhD; Sally Barrimore, MNutrDiet; John Endacott, MBBS; Nicholas Graves, PhD; Theresa Green, RN, PhD; Gill Harvey, PhD; Ruth Hubbard, MBBS, MD; Sue Kurrle,MD, PhD;Wen Kwang Lim, MBBS, MD; Karen Lee-Steere, BSci(OccThy); Phil Masel, MBBS; Shaun Pandy, MBBS; Adrienne Young, PhD;
Adrian Barnett, PhD; Sharon K. Inouye, MD, MPH
To read the full article please visit: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2788060
PCORI released the Prevention, Early Identification and Treatment of Delirium in Older Adults Targeted PCORI Funding Announcement
Patient-Centered Outcomes Research Institute (PCORI) released the Prevention, Early Identification and Treatment of Delirium in Older Adults Targeted PCORI Funding Announcement.
This funding announcement is seeking to fund high-quality, comparative effectiveness research (CER) projects that focus on the prevention, early identification, and treatment of delirium in older adults. PCORI will accept applications that propose rigorous multisite randomized controlled trials or robust well justified observational prospective studies. Applicants can propose to compare the effectiveness of single and multicomponent non pharmacologic interventions, pharmacological and/or nonpharmacological combination interventions. Applications focused on the needs of underserved, underrepresented, or historically excluded populations within hospital and long- term care settings are encouraged. Applicants will be asked to propose well-justified outcomes that are clinically meaningful and considered important by patients and/or their caregivers.
We invite you to review the funding announcement on our website for details and register for a town hall on January 24, 2022, at 12:00 pm (ET) where researchers and stakeholders will learn more about PCORI’s funding announcement on delirium.
USDeN and NIDUS Webinar: January 18, 2022 at 2pm ET
UB-CAM app is now available through Apple Store
Exciting news: UB-CAM App is now up and available in the Apple store (for the iPhone)!
UB-CAM Delirium Screen
Dr. Michael Devinney Awarded FAER GEMSSTAR Grant
Congratulations to Michael Devinney, MD, PhD, of Duke University School of Medicine on being awarded a FAER GEMSSTAR grant in 2021! Titled "The Association of Blood-Brain Barrier Breakdown with Sleep Apnea and Postoperative Delirium," download Dr. Devinney's project abstract to learn more.
2022-2023 Fellowship opportunity for candidates with a strong commitment to health and aging issues, leadership potential, and interest in aging-relevant policy: Due April 15, 2022
The Health and Aging Policy Fellows Program is currently in the recruitment cycle for its 15th cohort of Fellows. The deadline to apply is Friday, April 15, 2022 – so I wanted to reach out to encourage you to apply!
The year-long Health and Aging Policy Fellows program (www.healthandagingpolicy.org) offers a unique opportunity for professionals in health and aging to receive the experience and skills necessary to make a positive contribution to the development and implementation of health policies that affect older adults. The program is funded by The John A. Hartford Foundation, Atlantic Philanthropies, and West Health Policy Center. Fellows represent a wide range of disciplines across all career stages, and there are now 166 Fellows and Alumni around the country making a difference in the world of health policy in exciting and dynamic ways.
Please feel free to contact the HAPF National Program Office as well at firstname.lastname@example.org with any questions and to discuss this opportunity in further detail.
The US Deprescribing Research Network (USDeN) seeks applicants for its Junior Investigator Intensive Program in Deprescribing Research
The US Deprescribing Research Network (USDeN) seeks applicants for its Junior Investigator Intensive Program in Deprescribing Research. The program will create a cohort of emerging leaders who are committed to pursuing research training and collaborative opportunities related to deprescribing
Full Application Due: Feb 1, 2022
What is deprescribing research and why is it important?
There is increasing recognition that use of some medication, especially as people get older or more ill, can cause more harm than good. Optimizing medication through targeted deprescribing is a vital part of managing chronic conditions, avoiding adverse effects and improving outcomes. The goals of deprescribing include reducing medication burden and maintaining or improving quality of life. Yet, there is a dearth of strong research evidence to guide clinical practice and inform shared clinical decision-making relevant to deprescribing.
What is the Junior Investigator Intensive Program?
The program has 3 main components:
- Scholars will attend a special additional workshop at the 2022 US Deprescribing Research Network Annual Meeting (May 11, 2022, in Orlando, FL in conjunction with the AGS annual meeting) that is focused on career development, networking, and collaborative research opportunities for early-stage investigators interested in deprescribing.
- Scholars will attend monthly “work-in-progress” meetings, a core curriculum, and other activities over the year that offer a mix of opportunities to get feedback on your research from colleagues and senior researchers and discussion of collaborative research projects in which scholars can participate (and help lead).
- Scholars will have access to other aspects of the US Deprescribing Research Network such as attendance at webinars, consultations, and a variety of other resources. Scholars will be expected to attend the USDeN Annual Meeting and most of the monthly web-based meetings during the year.
Benefits of participation in the Junior Investigator Intensive
- Access to core resources and expertise of the US Deprescribing Research Network
- Get feedback on your research at virtual works-in-progress webinars and participate in collaborative research projects
- Attendance at the US Deprescribing Research Network Annual Meeting Session focused on Junior Investigators.
- Networking with both senior and junior colleagues interested in deprescribing for older adults
Who should apply to the Junior Investigator Intensive?
- MD, PhD, PharmD or equivalent degree (e.g., DO, DPT)
- Evidence of commitment to research in a field relevant to deprescribing
- People who have the time and interest to commit to the above-described activities
- The intended audience is early-stage faculty and qualified fellows/trainees/doctoral students or people in equivalent positions. While applications from other qualified people are also welcome, preference will be given to applicants who are in earlier stages of a research-focused career (e.g., up to 5 years in a research-oriented faculty position, not yet received an R01 or tenure).
- People outside the U.S. are welcome to apply
- Prospective applicants may apply to the USDeN Junior Investigator Intensive program and/or, separately, the USDeN Pilot Grant program. Individuals are permitted to receive both, and applications to either program do not affect consideration for the other.
ED Delirium Initiative- Qualitative study opportunity
Dr. Maura Kennedy and colleagues at Massachusetts General Hospital are conducting a qualitative research study about the implementation of delirium-related initiatives in emergency departments. If you have a program related to delirium identification, management and/or prevention, she would love to speak with an individual from your institution who was involved in implementing this program. Additional information about this study can be found here. If you were involved in program implementation, please consider participating in this study – you can contact Dr. Kennedy at email@example.com or can sign up for an interview at https://calendly.com/isantangelo1/deliriumqualprogram. If you were not involved in program implementation but do have a delirium-related program in your emergency department, please consider forwarding this email to someone who was involved in its implementation.
RCoA and BJA webinar from the Editor’s Desk joint with NIDUS - Postoperative delirium November 30th (6:30-8pm)
The RCoA and British Journal of Anaesthesia are pleased to announce a series of webinars available to our members on how to optimise your reading of the medical literature.
These webinars will feature members from our international editorial team and their guests including authors, experts and fellows addressing topics such as how to read the literature, the editorial process, and journal club discussions of important articles appearing in the BJA.
This Webinar addresses hot topics in Perioperative delirium based on recent publications in the British Journal of Anaesthesia and other high impact journals moderated by BJA editor Dr Michael Avidan.
Chairs: Hugh Hemmings and Michael Avidan, BJA
- Sharon Inouye, Professor of Medicine at Harvard Medical School and Director of the Aging Brain Center at the Marcus Institute for Aging Research, Hebrew SeniorLife
- Joyce Yeung, Associate Clinical Professor of Anaesthesia and Critical Care Medicine at the University of Warwick
- Bradley Fritz, Instructor of Anesthesiology at Washington University School of Medicine in St. Louis
This webinar is in collaboration with NIDUS (Network for investigation of Delirium: Unifying Scientists)
May 27: US Deprescribing Research Network's Virtual Annual Meeting
The US Deprescribing Research Network's virtual annual meeting will be held on May 27 from 11am - 2pm ET / 8am-11am PT. Sessions will include an interactive fireside chat with Kedar Mate (President and CEO of the Institute for Healthcare Improvement), presentation of new research on deprescribing, stakeholder perspectives, and thematic small group breakouts to promote networking and sharing of ideas for scholarship in this field. For more information and to register, visit https://deprescribingresearch.org/network-activities/annual-network-meeting/
NIDUS Career Development Webinar Series on March 25 12pm EST!
Our next session will feature Dr. Karin Neufeld, and how she used NIDUS resources to advance her systematic review and meta-analysis on use of antipsychotics in delirium, published recently in Ann Intern Med. Dr. Dale Needham was the senior author, who will join as the Moderator/Discussant at this session. Join the NIDUS investigators and NIA in this important session that will help you advance your career. Don’t miss out!
Here are the details:
Title: Use of the NIDUS Resources to Advance Research: A Real World Example
Who: Karin Neufeld, MD, MPH
When: Thursday, March 25, 12-1pm EST
Zoom link: https://psu.zoom.us/j/898303397
Phone: +1 312 626 6799 (US Toll), Meeting ID: 898 303 397
National Academy of Medicine Healthy Longevity Catalyst Awards
The National Academy of Medicine (NAM) will accept applications for the 2021 cycle of Healthy Longevity Catalyst Awards from January 25 through March 8, 2021. Up to 24 innovators will receive a cash prize of $50,000 plus travel costs to attend an international Innovator Summit.
The NAM Catalyst Awards will reward bold, new, potentially transformative ideas to improve the physical, mental, or social well-being and health of people as they age, in a measurable and equitable way. The NAM seeks innovative approaches that aim to extend the human healthspan, especially approaches that challenge existing paradigms or propose new methodologies or concepts.
The application process is uniquely simple – a 2-page proposal is all it takes to be considered for this one-of-a-kind award. The competition is open to U.S. residents or institutions of any background or discipline. For inspiration, check out the winners of the inaugural round of NAM Catalyst Awards, announced in October 2020.
The NAM Catalyst Awards are part of a larger, global competition available in over 50 countries and territories. The goal of this multiyear, multi-million-dollar contest is to accelerate progress in the growing field of healthy longevity. Ultimately, one or more Grand Prize(s) of up to $5 million will be awarded for the achievement of a breakthrough innovation.
Apply today for a chance to share your innovative idea with the world – and transform the future of aging!
Participants needed for research – Delirium in Palliative Care
The Del-COrS research group is currently looking for volunteers including patients, family members, carers, healthcare professionals and researchers with experience of delirium in palliative care.
Participants would complete two online surveys to establish their views on the outcomes that are important to include in future studies of interventions to prevent or to treat delirium in palliative care. We will subsequently invite participants to a meeting to discuss the findings and vote on outcomes they consider important.
Please contact firstname.lastname@example.org if you are interested in participating.
USDeN Pilot Grants and Junior Investigator Intensive Program
The US Deprescribing Research Network has 2 open opportunities!
Pilot and Grant Planning Awards - applications are now being accepted (deadline is January 22). Up to $60K per proposal for projects related to deprescribing research, For more information, see https://deprescribingresearch.org/network-activities/grant-opportunities/
Junior Investigator Intensive - applications are now being accepted (deadline is February 1). This year-long virtual program is designed to advance the scholarship and career development of fellows, junior faculty, and other early-stage investigators interested in a research career that involves deprescribing research. For more information, see https://deprescribingresearch.org/request-for-applicants-for-a-junior-investigator-intensive-program-in-deprescribing-research/
Living in disadvantaged neighborhoods doubles post-op delirium risk for older adults
A new study by Dr. Franchesca Arias and Dr. Sharon Inouye showed older adults who live in the most disadvantaged neighborhoods are two times more likely to experience delirium after surgery than their counterparts from more affluent communities. Read the full press release here.
Congratulations NIDUS Year 5 Pilot Grant Awardees!
The NIDUS Pilots and Innovation Task Force announces two new pilot grants to advance innovation in delirium research. The goal is to provide funding for investigation into innovative areas of delirium research and support research on priority areas. From a pool of over 40 applications, these two grants have been selected for funding during Year 5.
NIDUS is thrilled to partner with a new group of researchers to further the field of delirium research. We look forward to sharing news about their studies and outcomes.
Joseph Hippensteel, MD | University of Colorado
Potentiation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) by highly-sulfated chondroitin sulfate: a novel contributor to sepsis-associated delirium
Kimberly Oosterhouse, PhD | Loyola University Chicago
Computable Phenotyping of Delirium: Analyzing the Unstructured Data
Mobility Action Group: Using Quality Improvement Methods to Create a Culture of Hospital Mobility
The Mobility Action Group (MACT) and Change Package were developed to provide a conceptual framework, road map, and step‐by‐step guide to enable mobility teams to implement mobility programs successfully and meet their mobilization goals. The MACT and Chage Package provides an innovative approach emphasizing system wide change that can help catalyze a culture of mobility in hospitals across the nation, improving the quality of care for hospitalized older adults. Read the full article here.
Congratulations NIDUS Year 4 Pilot Grant Awardees!
The NIDUS Pilots and Innovation Task Force announces four new pilot grants to advance innovation in delirium research. The goal is to provide funding for investigation into innovative areas of delirium research and support research on priority areas. From a pool of over 40 applications, these four grants have been selected for funding during Year 4.
NIDUS is thrilled to partner with a new group of researchers to further the field of delirium research. We look forward to sharing news about their studies and outcomes.
Sean Barnes, MD | Johns Hopkins School of Medicine
Neurofunctional Outcomes and Biomarkers of Postoperative Delirium in Children after Cardiac Bypass Surgery
Sangil Lee, MD | University of Iowa Carver College of Medicine
Machine Learning Algorithm to Predict Delirium from Emergency Department Data
Michael Reznik, MD | Brown University
Validating the Fluctuating Mental Status Evaluation: A Novel Delirium Screening Tool for Critically Ill Patients with Stroke
Ravikanth Velagapudi, PhD | Duke University
Profiling Postoperative Neuroinflammation in a Mouse Model of Delirium Superimposed on Parkinson’s Disease
Joining Forces against Delirium — From Organ-System Care to Whole-Human Care By Sharon K. Inouye
"Rather than designating delirium as a “never event” for hospitals, Medicare could offer incentives for the use of proven strategies for preventing it — such as ensuring early mobility, reducing use of bed or chair alarms, minimizing use of psychoactive drugs, and providing adaptations for vision and hearing impairment — in order to motivate change."
Read more from Dr. Inouye's NEJM Perspectives piece here: https://www.nejm.org/doi/full/10.1056/NEJMp1910499
Bereavement Care in America is Broken: A Call to Action By Joyal Mulheron, Sharon K. Inouye
The death of a child, at any age, is one of the most – if not the most – stressful life events a person can go through. Bereavement is associated with severe health, social, and economic consequences – but sparse legal and social supports exist to protect grieving parents.
The authors of the newest NAM Perspectives commentary state that bereavement care in the United States is broken, and call for evidence-based research into the prevalence and outcomes of bereavement and how to best mitigate the adverse short- and long-term outcomes of coping with bereavement. The authors believe there is much that can be done to address this crisis, and that it must be approached with sensitivity and attention as we care for those who have experienced the profound loss of a child. Read more: https://doi.org/10.31478/202001e
New Randomized Clinical Trial Demonstrates Effectiveness of Adapted Hospital Elder Life Program
A new randomized controlled trial in JAMA Internal Medicine has demonstrated the effectiveness of the Hospital Elder Life Program (HELP), this time in an adapted, tailored format. The HELP Program reduces delirium and functional decline in hospitalized older adults through daily interventions, many of which are performed by volunteers.
This study enrolled 281 surgical patients at a hospital in China and compared a group receiving a tailored version of the HELP program (t-HELP) to a group receiving usual care with no HELP program. T-HELP included non-pharmacological interventions completed by family members (instead of volunteers) trained by nursing staff. Results demonstrated the effectiveness of this t-HELP format, as occurrence of delirium was only 2.6% in the t-HELP group while 19.4% in the usual care group. And even further, patients who received t-HELP program had greater recovery (both cognitive and functional) one month after surgery compared to the usual care group.
This is a very important study, as in China, family members are frequently involved in care of older persons but hospitals often do not utilize volunteers. This study demonstrates that HELP can be adapted to fit a variety of institutional formats. Read more about the study here: https://scienmag.com/family-members-can-assist-in-preventing-post-operative-delirium-by-as-much-as-16-8/
Leah Acker, MD, PhD, Assistant Professor of Anesthesiology, Duke University Medical Center, Durham, NC Outside of the delirium field, less complex physiological output signals often are associated with increased risk of geriatric syndromes. For example, an increased risk of falls is associated with less complex musculoskeletal adjustment movements.1 Overall, less complex physiological signals are associated […]
[updated 3/25/22] Applications for the 2022 NIDUS II Pilot Grant Awards are due Friday, April 1, 2022, 5:00PM EST. We have compiled responses to some NIDUS II Pilot Grant FAQs here to help assist applicants during the process. If you have additional questions or would like further clarification, then please contact NIDUS@hsl.harvard.edu. Also, applicants may […]
Every other month, the Delirium Research Hub selects an investigator and research study included in the Delirium Research Hub to feature as a Spotlight Investigator. This month, we are featuring Dr. Eyal Kimchi, MD, PhD for his study “Massachusetts General Hospital (MGH) Delirium Electroencephalography (EEG) Study.” This study investigates EEGs, a promising biomarker that has […]
Contributed by Olga Boukrina, Ph.D., Kessler Foundation Delirium is a multicomponent syndrome produced by a set of unique vulnerabilities (e.g., infection, advanced age, decreased cognitive functioning) and compounding causes (e.g., circadian dysregulation, oxidative stress, neuronal aging). The contribution of each individual factor and their interactions present a complicated picture, but unifying themes in this line […]
Every other month, the Delirium Research Hub selects an investigator and research study included in the Delirium Research Hub to feature as a Spotlight Investigator. This month, we are featuring Dr. Olga Boukrina, PhD, for her study “Neglect and Delirium,” which investigates a potential neural mechanism underlying the link between delirium and spatial neglect in […]