Monthly posts on new topics in delirium research

NIDUS Blog

Malissa Mulkey, PhD, APRN, CCNS, CCRN

Using Limited Lead Rapid Response EEG to Detect Delirium: A Proof-of-Concept Study

Malissa Mulkey, PhD, APRN, CCNS, CCRN Post-Doctoral Research Fellow, Indiana University Medical Center, Indianapolis, IN Based on the Diagnostic and Statistical Manual for Mental Disorders-Version 5 (DSM-V) delirium is defined as encompassing a reduction in attention, impairment in both cognition and memory and awareness.1 Historically, due to the high prevalence in the intensive care setting, […]

Delirium Research Hub Spotlight - Esther Oh, MD, PhD

Delirium Research Hub Spotlight – Esther Oh, MD, PhD

Every few months, the Delirium Research Hub selects an investigator and research study included in the Delirium Research Hub to feature as a Spotlight Investigator. This month, we are featuring Dr. Esther Oh. Her research focuses on the development of biomarkers for various stages of dementia, as markers of early detection and for markers of […]

Dr. Leah Acker

Do more complex brain electrical signals protect again post-operative delirium?

Leah Acker, MD, PhD, Assistant Professor of Anesthesiology, Duke University Medical Center, Durham, NC Outside of the delirium field, less complex physiological output signals often are associated with increased risk of geriatric syndromes. For example, an increased risk of falls is associated with less complex musculoskeletal adjustment movements.1 Overall, less complex physiological signals are associated […]

Matthew S. Duprey

Does Treating Incident ICU Delirium with Haloperidol Improve Outcomes?

Matthew S. Duprey, PharmD, PhD, BCCCP Investigator, Department of Health Services, Policy, and Practice, Brown University School of Public Health Practitioners familiar with delirium and its consequences have long sought a medication-based treatment to reduce its severity and duration in hospital and also improve post-hospitalization outcomes including long-term cognitive impairment. Despite three randomized controlled trials […]

Elizabeth Mahanna-Gabrielli, MD

Frailty, Postoperative Delirium and Cognitive Dysfunction: Where is the Association?

Contributed by Elizabeth Mahanna-Gabrielli, MD Department of Anesthesiology, Miller School of Medicine, University of Miami, Miami, Florida As a neuroanesthesiologist and intensivist, I’ve seen many frail patients come into the operating room and intensive care unit. During the early years of my career, frailty was informally defined as patient who was elderly, weak, and deconditioned; clinicians […]

Brian O'Gara, MD, MPH

Cognitive Prehabilitation to Prevent Postoperative Delirium

Contributed by Brian O’Gara MD MPH Department of Anesthesiology, Beth Israel Deaconess Medical Center, Boston, MA Postoperative delirium occurs in 15-50% of older surgical patients, and increases the risk of postoperative complications, hospital mortality and long-term cognitive dysfunction.1 Hospital -based multicomponent interventions can prevent postoperative delirium, but these approaches are only 30-40% effective.2 Therefore, there is […]

Dr. Michael Reznik

Studying Delirium in the Neurocritical Care Unit: Improving Detection and Outcomes in Patients with Stroke

Michael Reznik, MD Assistant Professor of Neurology & Neurosurgery. Brown University, Alpert Medical School I’ve been interested in brain science, consciousness, and cognition for as long as I can remember, and it was through the lens of these interests that I opted to pursue a career in neurology. I found myself especially interested in patients […]

Graph for Discordance between ICDSC and CAM-ICU-7 blog post

Discordance between ICDSC and CAM-ICU-7 as measures of delirium severity in the ICU

Karla D. Krewulak PhD and Kirsten M. Fiest PhD Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada Determination of delirium presence or absence may no longer be sufficient when tools exist to measure a delirium score which many be used to estimate delirium severity. Measurement of delirium severity has been identified as […]

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