Monthly posts on new topics in delirium research

NIDUS Blog

Matthew S. Duprey

Does Treating Incident ICU Delirium with Haloperidol Improve Outcomes?

Matthew S. Duprey, PharmD, PhD, BCCCP Investigator, Department of Health Services, Policy, and Practice, Brown University School of Public Health Practitioners familiar with delirium and its consequences have long sought a medication-based treatment to reduce its severity and duration in hospital and also improve post-hospitalization outcomes including long-term cognitive impairment. Despite three randomized controlled trials […]

Elizabeth Mahanna-Gabrielli, MD

Frailty, Postoperative Delirium and Cognitive Dysfunction: Where is the Association?

Contributed by Elizabeth Mahanna-Gabrielli, MD Department of Anesthesiology, Miller School of Medicine, University of Miami, Miami, Florida As a neuroanesthesiologist and intensivist, I’ve seen many frail patients come into the operating room and intensive care unit. During the early years of my career, frailty was informally defined as patient who was elderly, weak, and deconditioned; clinicians […]

Brian O'Gara, MD, MPH

Cognitive Prehabilitation to Prevent Postoperative Delirium

Contributed by Brian O’Gara MD MPH Department of Anesthesiology, Beth Israel Deaconess Medical Center, Boston, MA Postoperative delirium occurs in 15-50% of older surgical patients, and increases the risk of postoperative complications, hospital mortality and long-term cognitive dysfunction.1 Hospital -based multicomponent interventions can prevent postoperative delirium, but these approaches are only 30-40% effective.2 Therefore, there is […]

Dr. Michael Reznik

Studying Delirium in the Neurocritical Care Unit: Improving Detection and Outcomes in Patients with Stroke

Michael Reznik, MD Assistant Professor of Neurology & Neurosurgery. Brown University, Alpert Medical School I’ve been interested in brain science, consciousness, and cognition for as long as I can remember, and it was through the lens of these interests that I opted to pursue a career in neurology. I found myself especially interested in patients […]

Graph for Discordance between ICDSC and CAM-ICU-7 blog post

Discordance between ICDSC and CAM-ICU-7 as measures of delirium severity in the ICU

Karla D. Krewulak PhD and Kirsten M. Fiest PhD Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada Determination of delirium presence or absence may no longer be sufficient when tools exist to measure a delirium score which many be used to estimate delirium severity. Measurement of delirium severity has been identified as […]

Shawniqua Williams Roberson

Does Sleep Deprivation Cause Delirium? Exploring the Physiologic Links

Contributed by Shawniqua Williams Roberson, M.Eng., M.D., Departments of Neurology and Biomedical Engineering, Vanderbilt University Medical Center, Nashville, TN. Dr. Williams is a graduate of the 2019 NIDUS Bootcamp. Many of us are familiar with the feeling of not getting enough sleep. Perhaps a storm rattled the windows all night, or the baby couldn’t stop crying. […]

Delirium causing dementia graphic

Delirium, Dementia, and Adverse Outcomes

Contributed by Thiago J. Avelino-Silva, MD, PhD*; Flávia B. Garcez, MD, PhD* *Faculty of Medicine, University of São Paulo, São Paulo, Brazil Delirium results from an intricate combination of dozens of possible predisposing and precipitating factors1. Older age, functional dependence, and preexisting cognitive impairment are key determinants for its occurrence, but the latter is a […]

Delirium Research Hub Spotlight - Colm Cunningham

Delirium Research Hub Spotlight: Colm Cunningham, PhD

Every few months, the Delirium Research Hub selects an investigator and research study included in the Delirium Research Hub to feature as a Spotlight Investigator. This month, we are featuring Dr. Colm Cunningham for his study “Brain Vulnerability, Inflammation, and Energy Metabolism in Animal Models”. His research focuses on the role of systemic inflammation on […]

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