Contributed by Zachary Kunicki, PhD, Assistant Professor of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA; Richard Jones, PhD, Professor of Psychiatry and Human Behavior and Neurology, Warren Alpert Medical School of Brown University, Providence, RI, USA; and Sharon Inouye, MD MPH, Milton and Shirley F. Levy Family Chair […]
Category Archives: Delirium Research
The potential association between gut microbiota and delirium in acutely ill older adults: an important area for further investigation
Contributed by Flavia Barreto Garcez MD, PhD and Thiago Junqueira Avelino-Silva, MD, PhD Laboratorio de Investigacao Medica em Envelhecimento (LIM 66), Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazil The gut microbiota, the collection of microorganisms in our gastrointestinal tract,1 has gained increasing attention in recent years. It […]
The NIDUS Delirium Research Hub: 10 Questions
Recently, Dr. Ed Marcantonio, NIDUS Delirium Research Hub Leader, created a list of 10 Questions about the NIDUS Delirium Research Hub. Below is a preview of the list: 1) What is the NIDUS Delirium Research Hub? The Delirium Research Hub, one of five NIDUS cores, is a repository of meta-data (like a “table of contents”) […]
Using Qualitative Approaches to Understand the Subjective Experience of Postoperative Delirium
Contributed by Kelly Atkins, DPsych (Clin Neuro), Melbourne Medical School, University of Melbourne. Our Research Question Postoperative delirium is the most common adverse outcome affecting older adults after surgery and is associated with a cascade of negative outcomes1, 2. While research activity in the field of postoperative delirium has exploded, the subjective experience of postoperative […]
What is the preferred delirium screening tool in the post-anesthetic care unit?
Contributed by Rami K. Aldwikat1, Elizabeth Manias2, Alex C. Holmes3, Emily Tomlinson1 and Patricia Nicholson1 1 School of Nursing and Midwifery; Centre for Quality and Patient Safety Research in The Institute for Health Transformation, Geelong, Vic, Australia 2 School of Nursing and Midwifery, Monash University, Clayton, Victoria, Australia 3 Department of Mental Health, The Royal […]
Postoperative Delirium and Biomarkers of Alzheimer’s Disease: What We Know and What We Need to Know
Contributed by Dr. Sophia Wang, MD, MS, Assistant Professor of Clinical Psychiatry, Indiana University School of Medicine Postoperative delirium affects 15-50% of older adults undergoing major surgery.1 The literature strongly supports a bidirectional relationship between delirium and dementia.2 While both delirium and dementia affect cognition, they are quite different in their clinical presentations. Delirium is […]
Association between Symptom Domains of Delirium and Outcomes in Hospitalised Adults
Contributed by Zoë Tieges, PhD, Psychology Research Fellow, Geriatric Medicine, Usher Institute, The University of Edinburgh, Edinburgh, UK Research question: do patients with delirium experience poorer outcomes when they have certain symptoms? Delirium is a syndrome with a wide spectrum of clinical presentations. According to DSM-5 (and the recent DSM-5 Text Revision) criteria, the key […]
The Posterior Dominant Rhythm: A Proof-of-Principle Study Whether it is an Electroencephalographic Biomarker for Tracking Delirium Onset and Recovery
Contributed by Ben Julian A. Palanca, MD, PhD, MSc, Associate Professor of Anesthesiology, Associate Professor of Psychiatry, Washington University School of Medicine in St. Louis; Affiliated Faculty, Department of Biomedical Engineering, Washington University; Director, Sleepy Brain Lab Predictive biomarkers for prognosticating delirium onset and severity are needed for targeting interventions that may prevent delirium onset. […]
Selective Serotonin Reuptake Inhibitor (SSRI) Use and Delirium Occurrence in the ICU
Contributed by C. Adrian Austin, MD, MSCR, Divisions of Geriatric Medicine and Pulmonary Diseases and Critical Care Medicine, University of North Carolina School of Medicine, Chapel Hill, NC Anxiety, depression and ICU delirium may be linked.1 Approximately 10% of the U.S. population takes an antidepressant, most commonly a selective serotonin reuptake inhibitor (SSRI).2 It remains […]
A Conceptual Framework for Social Determinants of Health and Delirium (SDOH)
Franchesca Arias, PhD Assistant Professor, Department of Clinical and Health Psychology, University of Florida By 2050 it is expected that over 22% of the global population will be >60 years old.1 Late adulthood is a unique life stage2 associated with distinct cognitive vulnerabilities and medical needs. Of those ≥ 65 years old in the United […]