What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Drug therapy for delirium in terminally ill adults
- Authors
- Finucane, A. M. Jones, L. Leurent, B. Sampson, E. L. Stone, P. Tookman, A. Candy, B.
- Year
- 2020
- Journal
- Cochrane Database Syst Rev
- Abstract
BACKGROUND: Delirium is a syndrome characterised by an acute disturbance of attention and awareness which develops over a short time period and fluctuates in severity over the course of the day. It is commonly experienced during inpatient admission in the terminal phase of illness. It can cause symptoms such as agitation and hallucinations and is distressing for terminally ill people, their families and staff. Delirium may arise from any number of causes and treatment should aim to address these causes. When this is not possible, or treatment is unsuccessful, drug therapy to manage the symptoms may become necessary. This is the second update of the review first published in 2004. OBJECTIVES: To evaluate the effectiveness and safety of drug therapies to manage delirium symptoms in terminally ill adults. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, CINAHL and PsycINFO from inception to July 2019, reference lists of retrieved papers, and online trial registries. SELECTION CRITERIA: We included randomised controlled trials of drug therapies in any dose by any route, compared to another drug therapy, a non-pharmacological approach, placebo, standard care or wait-list control, for the management of delirium symptoms in terminally ill adults (18 years or older). DATA COLLECTION AND ANALYSIS: We independently screened citations, extracted data and assessed risk of bias. Primary outcomes were delirium symptoms; agitation score; adverse events. Secondary outcomes were: use of rescue medication; cognitive status; survival. We applied the GRADE approach to assess the overall quality of the evidence for each outcome and we include eight ‘Summary of findings’ tables. MAIN RESULTS: We included four studies (three new to this update), with 399 participants. Most participants had advanced cancer or advanced AIDS, and mild- to moderate-severity delirium. Meta-analysis was not possible because no two studies examined the same comparison. Each study was at high risk of bias for at least one criterion. Most evidence was low to very low quality, downgraded due to very serious study limitations, imprecision or because there were so few data. Most studies reported delirium symptoms; two reported agitation scores; three reported adverse events with data on extrapyramidal effects; and none reported serious adverse events. 1. Haloperidol versus placebo There may be little to no difference between placebo and haloperidol in delirium symptoms within 24 hours (mean difference (MD) 0.34, 95% confidence interval (CI) -0.07 to 0.75; 133 participants). Haloperidol may slightly worsen delirium symptoms compared with placebo at 48 hours (MD 0.49, 95% CI 0.10 to 0.88; 123 participants with mild- to moderate-severity delirium). Haloperidol may reduce agitation slightly compared with placebo between 24 and 48 hours (MD -0.14, 95% -0.28 to -0.00; 123 participants with mild- to moderate-severity delirium). Haloperidol probably increases extrapyramidal adverse effects compared with placebo (MD 0.79, 95% CI 0.17 to 1.41; 123 participants with mild- to moderate-severity delirium). 2. Haloperidol versus risperidone There may be little to no difference in delirium symptoms with haloperidol compared with risperidone within 24 hours (MD -0.42, 95% CI -0.90 to 0.06; 126 participants) or 48 hours (MD -0.36, 95% CI -0.92 to 0.20; 106 participants with mild- to moderate-severity delirium). Agitation scores and adverse events were not reported for this comparison. 3. Haloperidol versus olanzapine We are uncertain whether haloperidol reduces delirium symptoms compared with olanzapine within 24 hours (MD 2.36, 95% CI -0.75 to 5.47; 28 participants) or 48 hours (MD 1.90, 95% CI -1.50 to 5.30, 24 participants). Agitation scores and adverse events were not reported for this comparison. 4. Risperidone versus placebo Risperidone may slightly worsen delirium symptoms compared with placebo within 24 hours (MD 0.76, 95% CI 0.30 to 1.22; 129 participants); and at 48 hours (MD 0.85, 95% CI 0.32 to 1.38; 111 participants with mild- to moderate-severity delirium). There may be little to no difference in agitation with risperidone compared with placebo between 24 and 48 hours (MD -0.05, 95% CI -0.19 to 0.09; 111 participants with mild- to moderate-severity delirium). Risperidone may increase extrapyramidal adverse effects compared with placebo (MD 0.73 95% CI 0.09 to 1.37; 111 participants with mild- to moderate-severity delirium). 5. Lorazepam plus haloperidol versus placebo plus haloperidol We are uncertain whether lorazepam plus haloperidol compared with placebo plus haloperidol improves delirium symptoms within 24 hours (MD 2.10, 95% CI -1.00 to 5.20; 50 participants with moderate to severe delirium), reduces agitation within 24 hours (MD 1.90, 95% CI 0.90 to 2.80; 52 participants), or increases adverse events (RR 0.70, 95% CI -0.19 to 2.63; 31 participants with moderate to severe delirium). 6. Haloperidol versus chlorpromazine We are uncertain whether haloperidol reduces delirium symptoms compared with chlorpromazine at 48 hours (MD 0.37, 95% CI -4.58 to 5.32; 24 participants). Agitation scores were not reported. We are uncertain whether haloperidol increases adverse events compared with chlorpromazine (MD 0.46, 95% CI -4.22 to 5.14; 24 participants). 7. Haloperidol versus lorazepam We are uncertain whether haloperidol reduces delirium symptoms compared with lorazepam at 48 hours (MD -4.88, 95% CI -9.70 to 0.06; 17 participants). Agitation scores were not reported. We are uncertain whether haloperidol increases adverse events compared with lorazepam (MD -6.66, 95% CI -14.85 to 1.53; 17 participants). 8. Lorazepam versus chlorpromazine We are uncertain whether lorazepam reduces delirium symptoms compared with chlorpromazine at 48 hours (MD 5.25, 95% CI 0.38 to 10.12; 19 participants), or increases adverse events (MD 7.12, 95% CI 1.08 to 15.32; 18 participants). Agitation scores were not reported. SECONDARY OUTCOMES: use of rescue medication, cognitive impairment, survival There were insufficient data to draw conclusions or assess GRADE. AUTHORS’ CONCLUSIONS: We found no high-quality evidence to support or refute the use of drug therapy for delirium symptoms in terminally ill adults. We found low-quality evidence that risperidone or haloperidol may slightly worsen delirium symptoms of mild to moderate severity for terminally ill people compared with placebo. We found moderate- to low-quality evidence that haloperidol and risperidone may slightly increase extrapyramidal adverse events for people with mild- to moderate-severity delirium. Given the small number of studies and participants on which current evidence is based, further research is essential.
- PMID
- Keywords
- Page(s)
- Volume
- 1
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Serum HMGB1 as a predictor for postoperative delirium in elderly patients undergoing total hip arthroplasty surgery | Zou, Y. Wu, Y. Wei, A. Nie, H. Hui, S. Liu, C. Deng, T. | Adv Clin Exp Med | 2024 |
Hmgb1 |
| The impact of adhering to a quality indicator for sedation, analgesia, and delirium management on costs, revenues, and clinical outcomes in intensive care in Germany: A retrospective observational study | Zuber, A. Rubarth, K. Förster, F. Balzer, F. Spies, C. Fürstenau, D. Kumpf, O. | PLoS One | 2024 |
Humans |
| The association between intraoperative hypotension and postoperative delirium- a retrospective cohort analysis | Zarour, S. Weiss, Y. Abu-Ganim, M. Iacubovici, L. Shaylor, R. Rosenberg, O. Matot, I. Cohen, B. | Anesthesiology | 2024 |
Hypotension Postoperative delirium Elective surgery Elderly Intraoperative Hypotension 4A’s |
| Intensive Care Unit Sleep Promotion Bundle: Impact on Sleep Quality, Delirium, and Other Patient Outcomes | Gorecki, N. M. Prasun, M. A. | Crit Care Nurse | 2024 |
Humans |
| A prospective multi-center study quantifying visual inattention in delirium using generative models of the visual processing stream | Al-Hindawi, A. Vizcaychipi, M. Demiris, Y. | Sci Rep | 2024 |
Humans |
| Correlation of preoperative inflammatory factors and emotional disorders with postoperative delirium in patients with craniocerebral trauma | Cao, P. Jia, Z. Y. Zheng, T. Mei, T. | World J Psychiatry | 2024 |
Inflammatory factors |
| Critical Assessment of the Neurological Complications during High-Risk Anesthesia Procedures | Chaudhary, F. Ahmed, Z. Agrawal, D. K. | J Surg Res (Houst) | 2024 |
Analgesics |
| Association of triglyceride-glucose index and delirium in patients with sepsis: a retrospective study | Fang, Y. Dou, A. Shen, Y. Li, T. Liu, H. Cui, Y. Xie, K. | Lipids Health Dis | 2024 |
Humans |
| The Effects of Appropriate Perioperative Exercise on Perioperative Neurocognitive Disorders: a Narrative Review | Feng, H. Zhang, Z. Lyu, W. Kong, X. Li, J. Zhou, H. Wei, P. | Mol Neurobiol | 2024 |
Humans |
| Spanish Translation and Cultural Adaptation of the Intensive Care Unit Delirium Playbook | Fuentes, A. L. Makhija, H. Fine, J. M. Alicea Reyes, P. Diaz De Leon, B. Sanchez-Azofra, A. Rodriguez-Flores, L. Weston, J. Marquine, M. J. Hu, E. Espinosa-Meza, R. Serafin Higuera, I. R. Vacas Jacques, P. Pollack, D. Novelli, F. Ely, E. W. Malhotra, A. N | ATS Sch | 2024 |
critical illness |
| Predictiveness of preoperative laboratory values for postoperative delirium | Guttenthaler, V. Fidorra, J. Wittmann, M. Menzenbach, J. | Health Sci Rep | 2024 |
older adults |
| Delirium in psychiatric settings: risk factors and assessment tools in patients with psychiatric illness: a scoping review | Huang, C. Wu, B. Chen, H. Tao, H. Wei, Z. Su, L. Wang, L. | BMC Nurs | 2024 |
Delirium |
| Differences of anticholinergic drug burden between older hospitalized patients with and without delirium: a systematic review and meta-analysis based on prospective cohort studies | Ieong, C. Chen, T. Chen, S. Gao, X. Yan, K. He, W. Hong, H. Gu, Y. Chen, X. Yuan, G. | BMC Geriatr | 2024 |
Humans |
| Nursing diagnoses as factors associated with delirium among intensive care unit patients with sepsis: A retrospective correlational study | Ji, H. Oh, E. G. Choi, M. Kim, H. Y. Kim, Y. A. Lee, K. H. | J Adv Nurs | 2024 |
Humans |
| Effectiveness of a delirium risk assessment and multidisciplinary care approach in reducing delirium incidence among surgical intensive care unit patients: A retrospective pre-post intervention study | Hsiao, W. L. Hsieh, P. Y. Hsu, L. F. Lai, Y. H. Wang, M. L. Yeh, Y. C. | J Clin Anesth | 2024 |
Critically ill |
| Incidence of Adverse Events Using Flumazenil in Patients With Iatrogenic Benzodiazepine Delirium: A Retrospective Study | Hieger, M. A. Moore, P. W. Maskell, K. F. | Am J Ther | 2024 |
*Benzodiazepines/adverse effects/antagonists & inhibitors |
| Early Opioid Use and Postoperative Delirium Following Open Abdominal Aortic Aneurysm Repair | Gutierrez, R. D. Pepic, L. Lancaster, E. M. Gasper, W. J. Hiramoto, J. S. Conte, M. S. Bongiovanni, T. Iannuzzi, J. C. | Ann Vasc Surg | 2024 |
Postoperative Delirium Open Abdominal Aortic Aneurysm repair Opioids Oral Morphine Equivalents
|
| Cardio Delirium Day: national study on the prevalence of delirium in Italian cardiology wards | Frongillo, D. Barisone, M. Gilardi, R. Usmiani, T. Falsini, G. | G Ital Cardiol (Rome) | 2024 |
Humans |
| Electroencephalographic Measures of Delirium in the Perioperative Setting: A Systematic Review | Bruzzone, M. J. Chapin, B. Walker, J. Santana, M. Wang, Y. Amini, S. Kimmet, F. Perera, E. Rubinos, C. Arias, F. Price, C. | Anesth Analg | 2024 |
Postoperative Delirium EEG Systematic Review Preoperative delirium prediction
|
| National survey on perioperative cognitive dysfunction | Aldana, E. M. Pérez de Arriba, N. Valverde, J. L. Aldecoa, C. Fábregas, N. Fernández-Candil, J. L. | Rev Esp Anestesiol Reanim (Engl Ed) | 2024 |
Perioperative cognitive dysfunction |
| Standard versus High Cardiopulmonary Bypass Flow Rate: A Randomized Controlled Subtrial Comparing Brain Injury Biomarker Release | Keiller, A. C. Axelsson, M. Bragadottir, G. Lannemyr, L. Wijk, J. Blennow, K. Zetterberg, H. Bagge, R. O. | J Cardiothorac Vasc Anesth | 2024 |
brain injury |
| Olanzapine postinjection delirium/sedation syndrome after long-acting olanzapine depot injection presenting to the emergency department: practical guidelines for diagnosis and management | Kochen, S. A. Hakkers, C. S. van Gorp, F. de Lange, D. W. Haas, L. E. M. | Emerg Med J | 2024 |
accidental |
| Postoperative use of sleep aids and delirium in older adults after major surgery: A retrospective cohort study | Lee, S. B. Park, C. M. Levin, R. Kim, D. H. | J Am Geriatr Soc | 2024 |
pharmacoepidemiology |
| A first assessment of the safe brain initiative care bundle for addressing postoperative delirium in the postanesthesia care unit | Meco, B. C. Jakobsen, K. De Robertis, E. Buhre, W. Alkış, N. Kirkegaard, P. R. Hägi-Pedersen, D. Bubser, F. Koch, S. Evered, L. A. Saunders, S. J. Caterino, M. Paolini, F. Berger-Estilita, J. Radtke, F. M. | J Clin Anesth | 2024 |
Anesthesia |
| Transplantation-Associated Altered Mentation and Encephalopathy: A New Classification for Acute Neurocognitive Changes Associated with Hematopoietic Cell Transplantation from the ASTCT Committee on Practice Guidelines | Meyers, G. Bubalo, J. Eckstrom, E. Winsnes, K. Carpenter, P. A. Artz, A. Lin, R. J. | Transplant Cell Ther | 2024 |
Humans |
| High-risk factors for delirium in severely ill patients and the application of emotional nursing combined with pain nursing | Li, H. R. Guo, Y. | World J Psychiatry | 2024 |
Critical illness |
| Association between antidepressant use and delirium in older adults: an analysis of the World Health Organization's global pharmacovigilance database | Minoc, E. M. Villain, C. Benbrika, S. Chrétien, B. Descatoire, P. Heraudeau, M. Sassier, M. Pierre, M. Martinaud, O. Dolladille, C. Lelong-Boulouard, V. | BMC Geriatr | 2024 |
Humans |
| Educational interventions aimed at improving knowledge of delirium among nursing home staff-a realist review | Molitor, V. Busse, T. S. Giehl, C. Lauer, R. Otte, I. C. Vollmar, H. C. Thürmann, P. Holle, B. Palm, R. | BMC Geriatr | 2024 |
Humans |
| Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial | Nicklas, J. Y. Bergholz, A. Däke, F. Pham, H. H. D. Rabe, M. C. Schlichting, H. Skrovanek, S. Flick, M. Kouz, K. Fischer, M. Olotu, C. Izbicki, J. R. Mann, O. Fisch, M. Schmalfeldt, B. Frosch, K. H. Renné, T. Krause, L. Zöllner, C. Saugel, B. | BJA Open | 2024 |
anaesthesia |
| The utility of the Montreal cognitive assessment (MoCA) in detecting cognitive impairment in surgical populations - A systematic review and meta-analysis | Danquah, M. O. Yan, E. Lee, J. W. Philip, K. Saripella, A. Alhamdah, Y. He, D. Englesakis, M. Chung, F. | J Clin Anesth | 2024 |
Cognitive impairment |
| Bettering Sleep Hygiene to Decrease Delirium and Improve Patient Satisfaction on an Inpatient Oncology Unit | Donovan, T. Vonnes, C. Mason, T. M. | Clin J Oncol Nurs | 2024 |
Humans |
| The effect of fascia iliaca compartment block on postoperative delirium in elder adults undergoing hip surgery: A systematic review and meta-analysis of randomized controlled trials | Duan, R. Cao, L. Zhang, H. Li, P. Wu, X. Li, J. | Int J Orthop Trauma Nurs | 2024 |
Elderly |
| Risk factors and prediction model of delirium in elderly patients after hip arthroplasty | Duan, Y. Zhang, R. | Pak J Med Sci | 2024 |
Delirium |
| Delirium prevalence and delirium literacy across Italian hospital wards: a secondary analysis of data from the World Delirium Awareness Day 2023 | Ornago, A. M. Pinardi, E. Okoye, C. Mazzola, P. Ferrara, M. C. Finazzi, A. Nydahl, P. von Haken, R. Lindroth, H. Liu, K. Morandi, A. Bellelli, G. | Eur Geriatr Med | 2024 |
Delirium |
| Association of postoperative delirium with hypotension in critically ill patients after cardiac surgery: a prospective observational study | Othman, S. M. A. Aziz, M. A. A. Al-Mushiki, G. M. A. Sriwayyapram, C. Okubai, T. Al-Muwaffaq, G. Xu, Q. Alqudaimi, M. | J Cardiothorac Surg | 2024 |
Humans |
| Cerebral autoregulation-directed optimal blood pressure management reduced the risk of delirium in patients with septic shock | Peng, Q. Liu, X. Ai, M. Huang, L. Li, L. Liu, W. Zhao, C. Hu, C. Zhang, L. | J Intensive Med | 2024 |
Cerebral regional oxygen saturation |
| From Traditional Typing to Intelligent Insights: A Narrative Review of Directions Toward Targeted Therapies in Delirium | Potter, K. M. Prendergast, N. T. Boyd, J. G. | Crit Care Med | 2024 |
Humans |
| Associations of serum lactate and lactate clearance with delirium in the early stage of ICU: a retrospective cohort study of the MIMIC-IV database | Qian, X. Sheng, Y. Jiang, Y. Xu, Y. | Front Neurol | 2024 |
Mimic-iv |
| Delirium management in perioperative geriatric services: a narrative review of non-pharmaceutical strategies | Travers, R. Gagliardi, G. Ramseyer, M. | Front Psychiatry | 2024 |
case management |
| Decreased DTI-ALPS index in delirium: a preliminary MRI study | Tu, Y. Song, R. Xiong, F. Fu, X. | Neuroradiology | 2024 |
Dti-alps |
| Association between preoperative persistent hyperglycemia and postoperative delirium in geriatric hip fracture patients | Wang, W. Zhang, Y. Yao, W. Tang, W. Li, Y. Sun, H. Ding, W. | BMC Geriatr | 2024 |
Humans |
| Impact of a Delirium Protocol on Deliriogenic Medication Use in Hospitalized Older Veterans | Weygint, A. M. LaMarr, B. Lee, S. | Sr Care Pharm | 2024 |
Humans |
| Quetiapine Twice Daily Versus Bedtime Dosing in the Treatment of ICU Delirium | Hawthorne, A. Delgado, E. Battle, A. Norton, C. | J Pharm Pract | 2024 |
Humans |
| Epigenetic signals associated with delirium replicated across four independent cohorts | Nishizawa, Y. Thompson, K. C. Yamanashi, T. Wahba, N. E. Saito, T. Marra, P. S. Nagao, T. Nishiguchi, T. Shibata, K. Yamanishi, K. Hughes, C. G. Pandharipande, P. Cho, H. Howard, M. A., 3rd Kawasaki, H. Toda, H. Kanazawa, T. Iwata, M. Shinozaki, G. | Transl Psychiatry | 2024 |
Humans |
| The Genome-wide DNA methylation changes in gastrointestinal surgery patients with and without postoperative delirium: Evidence of immune process in its pathophysiology | Nishizawa, Y. Yamanashi, T. Nishiguchi, T. Kajitani, N. Miura, A. Matsuo, R. Tanio, A. Yamamoto, M. Sakamoto, T. Fujiwara, Y. Thompson, K. Malicoat, J. Yamanishi, K. Seki, T. Kanazawa, T. Iwata, M. Shinozaki, G. | J Psychiatr Res | 2024 |
DNA methylation |
| Retinal imaging with hand-held optical coherence tomography in older people with or without postoperative delirium after hip fracture surgery: A feasibility study | Noah, A. M. Spendlove, J. Tu, Z. Proudlock, F. Constantinescu, C. S. Gottlob, I. Auer, D. P. Dineen, R. A. Moppett, I. K. | PLoS One | 2024 |
Humans |
| A world-wide study on delirium assessments and presence of protocols | Nydahl, P. Liu, K. Bellelli, G. Benbenishty, J. van den Boogaard, M. Caplan, G. Chung, C. R. Elhadi, M. Gurjar, M. Heras-La Calle, G. Hoffmann, M. Jeitziner, M. M. Krewulak, K. Mailhot, T. Morandi, A. Nawa, R. K. Oh, E. S. Collet, M. O. Paulino, M. C. Lin | Age Ageing | 2024 |
Humans |
| The interrelationship between multiple long-term conditions (MLTC) and delirium: a scoping review | Richardson, S. J. Cropp, A. D. Ellis, S. W. Gibbon, J. Sayer, A. A. Witham, M. D. | Age Ageing | 2024 |
Adult |
| Experiences of healthcare staff caring for hospitalised people with delirium: a qualitative systematic review | Siostrom, K. Snowdon, D. Sriamareswaran, R. K. Law, Y. M. Jolliffe, L. Moran, C. | Age Ageing | 2024 |
Humans |
| Nurses prioritization processes to prevent delirium in patients at risk: Findings from a Q-Methodology study | Sist, L. Pezzolati, M. Ugenti, N. V. Cedioli, S. Messina, R. Chiappinotto, S. Rucci, P. Palese, A. | Geriatr Nurs | 2024 |
Humans |
| Effect of near-infrared spectroscopy on postoperative delirium in cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis | Sun, Q. Wu, W. | Front Cardiovasc Med | 2024 |
cardiac surgery |
| Outcomes associated with postoperative cognitive dysfunction: a systematic review and meta-analysis | Suraarunsumrit, P. Srinonprasert, V. Kongmalai, T. Suratewat, S. Chaikledkaew, U. Rattanasiri, S. McKay, G. Attia, J. Thakkinstian, A. | Age Ageing | 2024 |
Aged |
| Refeeding hypophosphatemia is a common cause of delirium in critically ill patients: A retrospective study | Xu, Y. Qian, Y. Liang, P. Liu, N. Dong, D. Gu, Q. Tang, J. | Am J Med Sci | 2024 |
Consciousness |
| Electroencephalography Monitoring for Preventing Postoperative Delirium and Postoperative Cognitive Decline in Patients Undergoing Cardiothoracic Surgery: A Meta-Analysis | Xue, S. Xu, A. X. Liu, H. Zhang, Y. | Rev Cardiovasc Med | 2024 |
cardiothoracic surgery |
| Occurrence and risk factors for post-stroke delirium: A systematic review and meta-analysis | Zhang, G. B. Li, H. Y. Yu, W. J. Ying, Y. Z. Zheng, D. Zhang, X. K. Wang, Y. G. Shi, G. Z. Huang, H. W. | Asian J Psychiatr | 2024 |
Delirium |
| Description of an individualised delirium intervention in intensive care units for critically ill patients delivered by an artificial intelligence-assisted system: using the TIDieR checklist | Zhang, S. Cui, W. Wu, Y. Ji, M. | J Res Nurs | 2024 |
artificial intelligence |
| Construction and validation of a risk prediction model for postoperative delirium in patients with off‑pump coronary artery bypass grafting | Zhang, Y. Ren, M. Zhai, W. Han, J. Guo, Z. | J Thorac Dis | 2024 |
Off-pump coronary artery bypass grafting (OPCABG) |
| Predicting the Risk of Postoperative Delirium in Elderly Patients Undergoing Hip Arthroplasty: Development and Assessment of a Novel Nomogram | Zhang, Y. Xie, L. J. Wu, R. J. Zhang, C. L. Zhuang, Q. Dai, W. T. Zhou, M. X. Li, X. H. | J Invest Surg | 2024 |
Humans |
| Postoperative delirium risk in patients with hyperlipidemia: A prospective cohort study | Zhao, Y. Zhong, K. Zheng, Y. Xia, X. Lin, X. Kowark, A. Wang, X. Zhang, D. Duan, X. | J Clin Anesth | 2024 |
Cognitive decline |
| Effect of phenylephrine versus ephedrine on the incidence of postoperative delirium in olderly adults undergoing knee arthroplasty under general anesthesia: a single-center trial | Zheng, C. Wang, B. Fu, J. Peng, H. Chen, Y. Hu, X. | Sci Rep | 2024 |
Humans |
| Remimazolam for anesthesia and sedation in cardiac surgery and for cardiac patients undergoing non-cardiac surgery: a systematic-narrative hybrid review | D'Andria Ursoleo, J. Licheri, M. Barucco, G. Losiggio, R. Frau, G. Pieri, M. Monaco, F. | Minerva Anestesiol | 2024 |
Humans |
| Nurses' perceptions of patient pain, delirium, and sedation assessments in the intensive care unit: A qualitative study | Correya, A. Rawson, H. Ockerby, C. Hutchinson, A. M. | Aust Crit Care | 2024 |
Adult intensive care unit |
| Extracellular Vesicle MicroRNAs as Predictive Biomarkers in Postoperative Delirium after Spine Surgery; Preliminary Study | Cho, Y. E. Kim, J. Vorn, R. Cho, H. Baek, W. Park, H. Yun, S. Kim, H. S. Cashion, A. K. Gill, J. Koo, B. N. Lee, H. | J Gerontol A Biol Sci Med Sci | 2024 |
Exosome |
| Trace of delirium after robotic lower abdominal tumor resection at different end-tidal carbon dioxide: a RCT trial | Chen, J. Liang, S. Wei, M. Ma, Y. Bi, T. Liu, Z. Song, Y. Chen, H. Wang, Y. | BMC Anesthesiol | 2024 |
Humans |
| Adverse events related to physical restraint use in intensive care units: A review of the literature | Berger, S. Grzonka, P. Amacher, S. A. Hunziker, S. Frei, A. I. Sutter, R. | J Intensive Med | 2024 |
Adverse event |
| Managing Postoperative Delirium in Patients Receiving Head and Neck Surgery: An Educational Overview | Babu, S. Kurian Sajith, B. | Clin J Oncol Nurs | 2024 |
Humans |
| Risk Factors for Postoperative Delirium Severity After Deep Brain Stimulation Surgery in Parkinson's Disease | Astalosch, M. Mousavi, M. Ribeiro, L. M. Schneider, G. H. Stuke, H. Haufe, S. Borchers, F. Spies, C. von Hofen-Hohloch, J. Al-Fatly, B. Ebersbach, G. Franke, C. Kühn, A. A. Kübler-Weller, D. | J Parkinsons Dis | 2024 |
Parkinson’s disease |
| A Dual-Camera Eye-Tracking Platform for Rapid Real-Time Diagnosis of Acute Delirium: A Pilot Study | Al-Hindawi, A. Vizcaychipi, M. Demiris, Y. | IEEE J Transl Eng Health Med | 2024 |
Humans |
| Effectiveness of nurse-led non-pharmacological interventions on outcomes of delirium in adults: A meta-analysis of randomized controlled trials | Wang, J. Lu, Y. Chen, X. Wu, Y. | Worldviews Evid Based Nurs | 2024 |
adult health |
| Association of blood glucose change with postoperative delirium after coronary artery bypass grafting in patients with diabetes mellitus: a study of the MIMIC-IV database | Wang, F. Mei, X. | Front Endocrinol (Lausanne) | 2024 |
Humans |
| The genetic relationship between hypotension and delirium: a Mendelian randomization study | Wang, C. Wu, J. Lin, Y. Liu, Z. Liufu, N. Cao, M. | Front Neurol | 2024 |
Mendelian randomization |
| Comparison of Propofol-Based Total Intravenous Anesthesia versus Volatile Anesthesia with Sevoflurane for Postoperative Delirium in Adult Coronary Artery Bypass Grafting Surgery: A Prospective Randomized Single-Blinded Study | Varsha, A. V. Unnikrishnan, K. P. Saravana Babu, M. S. Raman, S. P. Koshy, T. | J Cardiothorac Vasc Anesth | 2024 |
cardiopulmonary bypass |
| Diagnostics and treatment of impulse control disorders, psychosis and delirium: systemic review-based recommendations - guideline "Parkinson's disease" of the German Society of Neurology | Witt, K. Levin, J. van Eimeren, T. Hasan, A. Ebersbach, G. | J Neurol | 2024 |
Delirium |
| Potential mechanism of Taohong Siwu Decoction in preventing and treating postoperative delirium in intertrochanteric fracture patients based on retrospective analysis and network pharmacology | Ding, Z. Yu, Z. Sun, Z. Liu, X. Chen, R. | J Orthop Surg Res | 2024 |
Humans |
| Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery: The ENGAGES-Canada Randomized Clinical Trial | Deschamps, A. Ben Abdallah, A. Jacobsohn, E. Saha, T. Djaiani, G. El-Gabalawy, R. Overbeek, C. Palermo, J. Courbe, A. Cloutier, I. Tanzola, R. Kronzer, A. Fritz, B. A. Schmitt, E. M. Inouye, S. K. Avidan, M. S. | Jama | 2024 |
Postoperative Delirium Anesthesia EEG-guided anesthesia Intraoperative EEG waveform suppression Older Adults |
| Association Between Pupil Light Reflex and Delirium in Adults With Traumatic Brain Injury: Preliminary Findings | Lapierre, A. Proulx, A. Gélinas, C. Dollé, S. Alexander, S. Williamson, D. Bernard, F. Arbour, C. | J Neurosci Nurs | 2024 |
Delirium ICU Delirium Traumatic Brain Injury Pupillary light reflex Postextubation delirium
|
| Prevalence and risk factors of postoperative delirium in tumor patients after free flap reconstruction: A systematic review and meta-analysis of case-control studies | Li, Y. Li, Z. Lv, Q. Gu, Y. Qi, Y. Li, J. Liu, Y. Ma, G. | Surgery | 2024 |
Postoperative Delirium Flap transplantation surgery Risk Factors Proactive prevention measures Systematic Review |
| Risk factors and risk stratification approaches for delirium screening: A Geriatric Emergency Department Guidelines 2.0 systematic review | Seidenfeld, J. Lee, S. Ragsdale, L. Nickel, C. H. Liu, S. W. Kennedy, M. | Acad Emerg Med | 2024 |
Geriatrics Delirium Emergency Department delirium screening Risk factors Delirium risk scores Systematic review |
| Examining the impact of permissibility hypercapnia on postoperative delirium among elderly patients undergoing thoracoscopic-laparoscopic esophagectomy: A single-center investigative study | Song, J. Shao, Y. M. Zhang, G. H. Fan, B. Q. Tao, W. H. Liu, X. F. Huang, X. C. Hu, X. W. | Shock | 2024 |
Postoperative delirium Permissive hypercapnia ventilation thoracic surgery intraoperative respiration |
| Association between modified frailty index and postoperative delirium in patients after cardiac surgery: A cohort study of 2080 older adults | Cheng, H. Ling, Y. Li, Q. Li, X. Tang, Y. Guo, J. Li, J. Wang, Z. Ming, W. K. Lyu, J. | CNS Neurosci Ther | 2024 |
Humans |
| Role of Intraoperative Electroencephalography in Predicting Postoperative Delirium in Patients Undergoing Cardiovascular Surgeries | Al-Qudah, A. M. Sivaguru, S. Anetakis, K. Crammond, D. J. Balzer, J. R. Thirumala, P. D. Subramaniam, K. Sadhasivam, S. Shandal, V. | Clin Neurophysiol | 2024 |
Cardiopulmonary bypass |
| Differences in metalloproteinases and their tissue inhibitors in the cerebrospinal fluid are associated with delirium | Aksnes, M. Schibstad, M. H. Chaudhry, F. A. Neerland, B. E. Caplan, G. Saltvedt, I. Eldholm, R. S. Myrstad, M. Edwin, T. H. Persson, K. Idland, A. V. Pollmann, C. T. Olsen, R. B. Wyller, T. B. Zetterberg, H. Cunningham, E. Watne, L. O. | Commun Med (Lond) | 2024 |
Alzheimer’s disease, Diagnostic markers, Dementia |
| A retrospective cohort study comparing outcomes following hip fractures in Australian indigenous patients with non-Australian indigenous patients | Cheok, T. Bastick, K. George, D. Chan, T. S. Jaitly, A. Jayasekera, N. Bray, L. Poonnoose, P. M. Williams, K. | ANZ J Surg | 2024 |
hip fracture |
| Comparing BIS Monitoring vs. Clinical Assessment for Deep Sedation in the ICU: Effects on Delirium Reduction and Sedative Drug Doses - A randomized trial | Huespe, I. Giunta, D. Acosta, K. Avila, D. Prado, E. Sanghavi, D. Carboni Bisso, I. Giannasi, S. Carini, F. C. | Chest | 2024 |
Bispectral Index,electroencephalogram-based sedation |
| Pharmacologic Management of End-of-Life Delirium: Translating Evidence into Practice | Hui, D. Cheng, S. Y. Paiva, C. E. | Cancers (Basel) | 2024 |
antipsychotic agents |
| Boarding Duration in the Emergency Department and Inpatient Delirium and Severe Agitation | Joseph, J. W. Elhadad, N. Mattison, M. L. P. Nentwich, L. M. Levine, S. A. Marcantonio, E. R. Kennedy, M. | JAMA Netw Open | 2024 |
Humans |
| Boarding Duration in the Emergency Department and Inpatient Delirium and Severe Agitation | Joseph, J. W. Elhadad, N. Mattison, M. L. P. Nentwich, L. M. Levine, S. A. Marcantonio, E. R. Kennedy, M. | JAMA Netw Open | 2024 |
Humans |
| Perioperative Blood Transfusion and Delirium after Total Knee or Hip Arthroplasty: Retrospective Analysis | Kim, S. Oh, T. K. Song, I. A. | J Pers Med | 2024 |
blood trans fusion |
| Randomized feasibility trial for evaluating the impact of primary nursing on delirium duration during intensive care unit stay | Krüger, L. Zittermann, A. Mannebach, T. Wefer, F. Becker, T. Lohmeier, S. Lüttermann, A. von Dossow, V. Rojas, S. V. Gummert, J. Langer, G. | Intensive Crit Care Nurs | 2024 |
Delirium |
| Patient recall of intensive care delirium: A qualitative investigation | la Cour, K. N. Andersen-Ranberg, N. C. Mortensen, C. Poulsen, L. M. Mathiesen, O. Egerod, I. Collet, M. | Acta Anaesthesiol Scand | 2024 |
critical care |
| Sevoflurane multiple Wash In/Wash Out at the end of anesthesia to reduce agitation: A multicenter double-blind randomized controlled trial | Landoni, G. Likhvantsev, V. V. Berikashvili, L. B. Yavorovsky, A. G. Bagdasarov, P. S. Smirnova, A. V. Serkova, T. S. Subbotin, V. V. Kadantseva, K. K. Ovezov, A. M. Yadgarov, M. Y. Yakovlev, A. A. Lamacchia, A. Gallo, L. Gracheva, N. D. Ryzhkov, P. V. Zi | Contemp Clin Trials Commun | 2024 |
Anesthesia |
| Predictive model and discriminant analysis of the development of dementia in patients with delirium in the emergency department | Lupiáñez Seoane, P. Muñoz Negro, J. E. Torres Parejo, U. Gómez Jiménez, F. J. | Semergen | 2024 |
Comorbidity |
| Machine learning for the prediction of delirium in elderly intensive care unit patients | Ma, R. Zhao, J. Wen, Z. Qin, Y. Yu, Z. Yuan, J. Zhang, Y. Wang, A. Li, C. Li, H. Chen, Y. Han, F. Zhao, Y. Sun, S. Ning, X. | Eur Geriatr Med | 2024 |
Delirium |
| A Novel Preoperative Electroencephalogram-Derived Index to Predict Early Postoperative Delirium in Elderly Patients After Hip Fracture Surgeries: Development of a Prediction Model | Nawan, A. Wang, G. Zhao, C. Zhang, W. Jiang, B. Feng, Y. | Geriatr Orthop Surg Rehabil | 2024 |
delirium index |
| Fixed dose ketamine for prehospital management of hyperactive delirium with severe agitation | O'Brien, M. C. Kelleran, K. J. Burnett, S. J. Hausrath, K. A. Kneer, M. S. Nan, N. Ma, C. X. McCartin, R. W. Clemency, B. M. | Am J Emerg Med | 2024 |
Humans |
| Platelet Bioenergetics and Associations With Delirium and Coma in Patients With Sepsis: A Prospective Cohort Study | Onyemekwu, C. A. Prendergast, N. T. Potter, K. M. Toney, N. A. Nouraie, M. S. Shiva, S. Girard, T. D. | CHEST Crit Care | 2024 |
acute brain dysfunction |
| Enhancing European Management of Analgesia, Sedation, and Delirium: A Multinational, Prospective, Interventional Before-After Trial | Paul, N. Grunow, J. J. Rosenthal, M. Spies, C. D. Page, V. J. Hanison, J. Patel, B. Rosenberg, A. von Haken, R. Pietsch, U. Schrag, C. Waydhas, C. Schellongowski, P. Lobmeyr, E. Sander, M. Piper, S. K. Conway, D. Totzeck, A. Weiss, B. | Neurocrit Care | 2024 |
Humans |
| EEG and acute confusional state at the emergency department | Prud'hon, S. Amiel, H. Zanin, A. Revue, E. Kubis, N. Lozeron, P. | Neurophysiol Clin | 2024 |
Humans |
| Preoperative Delirium Risk Screening in Patients Undergoing a Cardiac Surgery: Results from the Prospective Observational FINDERI Study | Sadlonova, M. Hansen, N. Esselmann, H. Celano, C. M. Derad, C. Asendorf, T. Chebbok, M. Heinemann, S. Wiesent, A. Schmitz, J. Bauer, F. E. Ehrentraut, J. Kutschka, I. Wiltfang, J. Baraki, H. von Arnim, C. A. F. | Am J Geriatr Psychiatry | 2024 |
Humans |
| Predicting postoperative delirium after percutaneous transluminal angioplasty and stenting in patients with intracranial atherosclerotic stenosis | Zhu, W. Shen, Y. Zhao, H. Tang, Y. Wang, X. Li, S. | Neurol Res | 2024 |
Postoperative delirium |