Delirium Bibliography

Delirium Bibliography books graphicWhat is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title
Stroke severity predicts poststroke delirium and its association with dementia: Longitudinal observation from a low income setting.
Authors
Ojagbemi A, Owolabi M, Bello T, Baiyewu O
Year
2017
Journal
Journal of the neurological sciences
Abstract

The effect of delirium on stroke outcome has not been quantified in sub-Saharan Africa. We investigated the prevalence of delirium occurring within one week of stroke in Nigerian survivors and its association with dementia and mortality at 3months.

PMID

28320171

Keywords
Page(s)
376-381
Issue

Search:
Total Records Found: 6289, showing 100 per page
TitleAuthorsJournalYearKeywords
Different Sedation Strategies in Older Patients Receiving Spinal Anesthesia for Hip Surgery on Postoperative Delirium: A Randomized Clinical Trial Zhu, S. Liu, Y. Wang, X. Wang, L. Li, J. Xue, X. Li, Z. Liu, J. Liu, X. Zhao, S. Drug Des Devel Ther 2023

Humans, Aged, Propofol/adverse effects, Emergence Delirium, Hypnotics and Sedatives/adverse effects, Dexmedetomidine/adverse effects, Anesthesia, Spinal/adverse effects, Delirium/etiology, Postoperative Complications/epidemiology, anesthetics, hip surgery, propofol, spinal anesthesia

Frailty and post-operative delirium influence on functional status in patients with hip fracture: the GIOG 2.0 study Gandossi, C. M. Zambon, A. Ferrara, M. C. Tassistro, E. Castoldi, G. Colombo, F. Mussi, C. Martini, E. Sergi, G. Coin, A. Zatti, G. Trevisan, C. Volpato, S. Ungar, A. Bellelli, G. Aging Clin Exp Res 2023

Humans
Aged, 80 and over
*Frailty/complications
*Emergence Delirium
Functional Status
*Delirium
Prospective Studies
*Hip Fractures/surgery
Risk Factors
Delirium
Frailty
Functional outcome
Hip fracture
Orthogeriatric

Associations between Alzheimer's disease biomarkers and postoperative delirium or cognitive dysfunction: A meta-analysis and trial sequential analysis of prospective clinical trials Geng, J. Zhang, Y. Chen, H. Shi, H. Wu, Z. Chen, J. Luo, F. Eur J Anaesthesiol 2023
Delirium in oncological palliative care and clinical cardiology units: A comparative analysis Grisales, E. S. Higuita, A. M. Correa, M. E. Gómez, J. J. V. González, C. P. Daveloza, A. K. Vásquez, J. G. F. Palliat Support Care

Humans
*Delirium/epidemiology/etiology/diagnosis
Palliative Care
Cross-Sectional Studies
*Dementia/complications
*Cardiology
Cardiology
Delirium
Dementia
Oncological palliative care

Risk Factors and Associated Outcomes of Postoperative Delirium After Open Abdominal Aortic Aneurysm Repair Gutierrez, R. D. Smith, E. J. T. Matthay, Z. A. Gasper, W. J. Hiramoto, J. S. Conte, M. S. Finlayson, E. Walter, L. C. Iannuzzi, J. C. J Vasc Surg 2023

abdominal aortic aneurysm (AAA)
delirium
open AAA repair (OAR)

Effect of preoperative sleep disorders on delirium in proximal femoral surgery patients aged 60 or older Han, F. Liu, X. Huang, H. Chu, H. Feng, W. BMC Anesthesiol 2023

Humans
Middle Aged
*Delirium/diagnosis/epidemiology/etiology
*Hip Fractures/surgery
Postoperative Complications/epidemiology/diagnosis
Risk Factors
Prospective Studies
*Emergence Delirium/complications
*Proximal Femoral Fractures
Hip fractures
Postoperative delirium
Sleep disorder

Electroencephalogram measured functional connectivity for delirium detection: a systematic review Hanna, A. Jirsch, J. Alain, C. Corvinelli, S. Lee, J. S. Front Neurosci 2023

Eeg
delirium
electroencephalography
functional connectivity
review

Development and evaluation of a concise nurse-driven non-pharmacological delirium reduction workflow for hospitalized patients: An interrupted time series study Harrison, J. D. Rathfon, M. Binford, S. Miranda, J. Oreper, S. Holt, B. Rogers, S. E. Geriatr Nurs 2023

Delirium
Hospitals
Intervention studies
Nurses
Quality improvement

Predicting postoperative delirium after cardiovascular surgeries from preoperative portable electroencephalography oscillations Hata, M. Miyazaki, Y. Nagata, C. Masuda, H. Wada, T. Takahashi, S. Ishii, R. Miyagawa, S. Ikeda, M. Ueno, T. Front Psychiatry 2023

Eeg
cardiovascular surgery
delirium
machine learning
power spectrum density

Lower alpha frequency of intraoperative frontal EEG is associated with postoperative delirium: A secondary propensity-matched analysis Hight, D. Ehrhardt, A. Lersch, F. Luedi, M. M. Stüber, F. Kaiser, H. A. J Clin Anesth 2023

Alpha rhythm
Anesthesia, general
Delirium, postoperative
Electroencephalography
Monitoring, intraoperative

Inflammatory and nutritional markers predict the risk of post-operative delirium in elderly patients following total hip arthroplasty Hu, W. Song, Z. Shang, H. Wang, J. Hao, Y. Front Nutr 2023

inflammatory markers
nomogram
nutritional markers
post-operative delirium
total hip arthroplasty

Evaluation of brain nerve function in ICU patients with Delirium by deep learning algorithm-based resting state MRI Huang, X. Jiang, R. Peng, S. Wei, Y. Hu, X. Chen, J. Lian, W. Open Life Sci 2023

brain nerve function
deep learning algorithm
delirium
resting state MRI

Prevention and treatment of traumatic brain injury-related delirium: a systematic review Huang, Y. Q. Weiss, S. Gros, P. Wong, E. Piché, P. P. Vyas, M. V. Tam, A. K. H. Watt, J. A. J Neurol 2023

Humans
Aged
Adult
Middle Aged
Haloperidol/therapeutic use
*Brain Injuries, Traumatic/therapy/drug therapy
*Propofol
*Delirium/etiology/prevention & control
Delirium
Non-pharmacologic
Pharmacologic
Prevention
Traumatic brain injury
Treatment

The Efficacy of Dexmedetomidine alone or with Melatonin on Delirium after Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial Javaherforooshzadeh, F. Babazadeh Dezfoli, A. Saki Malehi, A. Gholizadeh, B. Anesth Pain Med 2023

Cardiac Surgery
Coronary Artery Bypass Graft
Dexmedetomidine
Elderly Patients
Melatonin
Postoperative Delirium

Cerebral autoregulation-based mean arterial pressure targets and delirium in critically ill adults without brain injury: a retrospective cohort study Khan, J. M. Shore, A. Lee, K. F. H. Wood, M. D. Maslove, D. M. Hunt, M. Georgescu, I. Muscedere, J. Boyd, J. G. Can J Anaesth 2023

cerebral autoregulation
critically ill
delirium
near-infrared spectroscopy
optimal mean arterial blood pressure (MAPopt)

Clinical Features of Delirium among Patients in the Intensive Care Unit According to Motor Subtype Classification: A Retrospective Longitudinal Study Kim, J. Oh, J. Ahn, J. S. Chung, K. Kim, M. K. Shin, C. S. Park, J. Y. Yonsei Med J 2023

Humans
Retrospective Studies
Longitudinal Studies
*Delirium/diagnosis/drug therapy/epidemiology
*Antipsychotic Agents/therapeutic use
Intensive Care Units
Delirium
antipsychotics
intensive care unit
physical restraint

The Efficacy of Ramelteon to Prevent Postoperative Delirium After General Anesthesia in the Elderly: A Double-Blind, Randomized, Placebo-Controlled Trial Kinouchi, M. Mihara, T. Taguri, M. Ogura, M. Am J Geriatr Psychiatry 2023

Aged
Humans
*Emergence Delirium/chemically induced/complications/drug therapy
*Delirium/epidemiology
*Indenes/adverse effects
Anesthesia, General/adverse effects
Double-Blind Method
Elective surgery
general anesthesia
melatonin receptor agonist
postoperative delirium
randomized controlled trial

Association of general anesthesia exposure with risk of postoperative delirium in patients receiving transcatheter aortic valve replacement: a meta-analysis and systematic review Ko, C. C. Hung, K. C. Chang, Y. P. Liu, C. C. Cheng, W. J. Wu, J. Y. Li, Y. Y. Lin, T. C. Sun, C. K. Sci Rep 2023

Delirium is a heterogeneous and detrimental mental condition often seen in older, hospitalized patients and is currently hard to predict. In this study, we leverage large-scale, real- world data using the electronic health records (EHR) to identify two cohorts comprised of 7,492 UCSF patients and 19,417 UC health system patients (excluding UCSF patients) with an inpatient delirium diagnosis and the same number of propensity score-matched control patients without delirium. We found significant associations between comorbidities or laboratory test values and an inpatient delirium diagnosis which were validated independently. Most of these associations were those previously-identified as risk factors for delirium, including metabolic abnormalities, mental health diagnoses, and infections. Some of the associations were sex- specific, including those related to dementia subtypes and infections. We further explored the diagnostic associations with anemia and bipolar disorder by conducting longitudinal analyses from the time of first diagnosis of the risk factor to development of delirium demonstrating a significant relationship across time. Finally, we show that an inpatient delirium diagnosis leads to dramatic increases in mortality outcome across both cohorts. These results demonstrate the powerful application of leveraging EHR data to shed insights into prior diagnoses and laboratory test values that could help predict development of inpatient delirium and emphasize the importance of considering patient demographic characteristics including documented sex when making these assessments. ONE SENTENCE SUMMARY: Longitudinal analysis of electronic health record data reveals associations between inpatient delirium, comorbidities, and mortality.

Sex-stratified phenotyping of comorbidities associated with an inpatient delirium diagnosis using real world data Kodama, L. Woldemariam, S. Tang, A. Li, Y. Oskotsky, T. Raphael, E. Sirota, M. medRxiv 2023

Delirium is a heterogeneous and detrimental mental condition often seen in older, hospitalized patients and is currently hard to predict. In this study, we leverage large-scale, real- world data using the electronic health records (EHR) to identify two cohorts comprised of 7,492 UCSF patients and 19,417 UC health system patients (excluding UCSF patients) with an inpatient delirium diagnosis and the same number of propensity score-matched control patients without delirium. We found significant associations between comorbidities or laboratory test values and an inpatient delirium diagnosis which were validated independently. Most of these associations were those previously-identified as risk factors for delirium, including metabolic abnormalities, mental health diagnoses, and infections. Some of the associations were sex- specific, including those related to dementia subtypes and infections. We further explored the diagnostic associations with anemia and bipolar disorder by conducting longitudinal analyses from the time of first diagnosis of the risk factor to development of delirium demonstrating a significant relationship across time. Finally, we show that an inpatient delirium diagnosis leads to dramatic increases in mortality outcome across both cohorts. These results demonstrate the powerful application of leveraging EHR data to shed insights into prior diagnoses and laboratory test values that could help predict development of inpatient delirium and emphasize the importance of considering patient demographic characteristics including documented sex when making these assessments. ONE SENTENCE SUMMARY: Longitudinal analysis of electronic health record data reveals associations between inpatient delirium, comorbidities, and mortality.

Comparison of the effectiveness of delirium evaluation tools in intensive care patients: pre-deliric versions 1 and 2, E-pre-deliric and ICDSC Kucuk, O. Memis, D. Inal, M. T. Turan, F. N. Memis, I. Eur Rev Med Pharmacol Sci 2023

Male
Humans
Adult
Middle Aged
Aged
Female
*Delirium/diagnosis
Checklist
Reproducibility of Results
Prospective Studies
Critical Care/methods
Intensive Care Units

New-onset delirium during hospitalization in older adults: incidence and risk factors Lami Pereira, R. Bojanini Molina, L. Wilger, K. Hedges, M. S. Tolaymat, L. Haga, C. Walker, A. Gillis, M. Yin, M. Dawson, N. L. Hosp Pract (1995) 2023

Humans
Aged
Incidence
Retrospective Studies
*Delirium/epidemiology/diagnosis
Hospitalization
Length of Stay
Risk Factors
Confusion
Delirium
Encephalopathy
elderly

The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study Lu, W. Lin, S. Wang, C. Jin, P. Bian, J. Int J Gen Med 2023

geriatric
hip arthroplasty
neutrophil to lymphocyte ratio
platelet to lymphocyte ratio
postoperative delirium
systemic inflammation response index

Incidence of delirium in older people with cancer: Systematic review and meta-analysis Martínez-Arnau, F. M. Buigues, C. Pérez-Ros, P. Eur J Oncol Nurs 2023

Cancer
Delirium
Incidence
Older
meta-Analyses

Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) for the diagnosis of delirium in adults in critical care settings Miranda, F. Gonzalez, F. Plana, M. N. Zamora, J. Quinn, T. J. Seron, P. Cochrane Database Syst Rev 2023

Adult
Humans
Middle Aged
Aged
*Intensive Care Units
Sensitivity and Specificity
*Delirium/diagnosis
Critical Care

Exploration of key drug target proteins highlighting their related regulatory molecules, functional pathways and drug candidates associated with delirium: evidence from meta-data analyses Mosharaf, M. P. Alam, K. Gow, J. Mahumud, R. A. BMC Geriatr 2023

Humans
Gene Regulatory Networks
Proteomics
*MicroRNAs/genetics
Transcription Factors/genetics
*Delirium/drug therapy
Delirium
Drug repurposing
Hub-proteins
Transcription factors
microRNA

Development of postoperative delirium prediction models in patients undergoing cardiovascular surgery using machine learning algorithms Nagata, C. Hata, M. Miyazaki, Y. Masuda, H. Wada, T. Kimura, T. Fujii, M. Sakurai, Y. Matsubara, Y. Yoshida, K. Miyagawa, S. Ikeda, M. Ueno, T. Sci Rep 2023

delirium, postoperative, machine learning, cardiovascular, hospital

EEG microstate quantifiers and state space descriptors during anaesthesia in patients with postoperative delirium: a descriptive analysis Neuner, B. Wolter, S. McCarthy, W. J. Spies, C. Cunningham, C. Radtke, F. M. Franck, M. Koenig, T. Brain Commun 2023

EEG microstates
EEG state space descriptors
anaesthesia
multichannel EEG
postoperative delirium

Efficacy and Safety of Risperidone in Patients With Delirium: The RIDDLE Pilot Study Nguyen, P. V. Vu, T. T. M. Aust Crit CareJ Clin Psychopharmacol 2023

delirium, pilot study, risperidone, delirium rating scale, hospital

Intensive care unit nurses' perception of three different methods for delirium screening: A survey (DELIS-3) Nielsen, A. H. Larsen, L. K. Collet, M. O. Lehmkuhl, L. Bekker, C. Jensen, J. F. Laerkner, E. Nielsen, T. A. Rossen, B. S. Thorn, L. Laursen, E. Fischer, S. Villumsen, M. Shiv, L. H. Høgh, M. Rahr, M. N. Svenningsen, H. Aust Crit Care 2023

Humans
*Delirium/diagnosis
Cross-Sectional Studies
Intensive Care Units
Critical Care/methods
Perception
*Nurses
Critical care
Critical illness
Delirium
Encephalopathy
Intensive care nursing
Screening

Melatonin and Melatonin Agonists for Prevention of Delirium in the Cardiac Surgical ICU: A Meta-analysis Niyogi, S. G. Naskar, C. Singh, A. Kumar, B. Grover, S. Indian J Crit Care Med 2023

Cardiac critical care
Melatonin
Postoperative delirium

Association between Neuron-Specific Enolase, Memory Function, and Postoperative Delirium after Transfemoral Aortic Valve Replacement Nübel, J. Buhre, C. Hoffmeister, M. Oess, S. Labrenz, O. Jost, K. Hauptmann, M. Schön, J. Fritz, G. Butter, C. Haase-Fielitz, A. J Cardiovasc Dev Dis 2023

Tavr
cognitive assessment
memory function
neuron-specific enolase
postoperative delirium

A retrospective, cross-sectional analysis of delirium in burn injury compared to other surgical specialities O'Brien, A. Hopkins, J. Boardman, G. Stanley, G. Daly, P. Martin, L. Wood, F. Burns 2023

Humans
Intensive Care Units
Retrospective Studies
Cross-Sectional Studies
*Delirium/epidemiology/etiology
*Burns/complications/epidemiology/surgery
Burns
Delirium
General surgery
Intensive care
Orthopaedic surgery
Plastic surgery

Postoperative Use of the Muscle Relaxants Baclofen and/or Cyclobenzaprine Associated With an Increased Risk of Delirium Following Lumbar Fusion Perez, E. A. Ray, E. Gold, C. J. Park, B. J. Piscopo, A. Carnahan, R. M. Banks, M. Sanders, R. D. Olinger, C. R. Mueller, R. N. Woodroffe, R. W. Spine (Phila Pa 1976) 2023

Humans
Aged
Cohort Studies
*Baclofen/adverse effects
Retrospective Studies
*Emergence Delirium/complications
Muscles
Postoperative Complications/chemically induced/epidemiology

Extracellular Vesicles as Possible Plasma Markers and Mediators in Patients with Sepsis-Associated Delirium-A Pilot Study Plaschke, K. Brenner, T. Fiedler, M. O. Hölle, T. von der Forst, M. Wolf, R. C. Kopitz, J. Gebert, J. Weigand, M. A. Int J Mol Sci 2023

Humans
Pilot Projects
*Sepsis-Associated Encephalopathy/metabolism
Longitudinal Studies
*Extracellular Vesicles/metabolism
Proteome/metabolism
Biomarkers/metabolism
Aryldialkylphosphatase/metabolism
intensive care unit
plasma extracellular vesicles (EVs)
proteomics
sepsis-associated delirium (SAD)

Rest-activity patterns associated with delirium in patients with intracerebral hemorrhage Reznik, M. E. Mintz, N. Moody, S. Drake, J. Margolis, S. A. Rudolph, J. L. LaBuzetta, J. N. Kamdar, B. B. Jones, R. N. J Neurol Sci 2023

Humans
*Delirium/etiology
Cerebral Hemorrhage/complications
*Stroke/complications
Actigraphy
Hospitalization
Delirium
Sleep
Stroke

Development and validation of delirium prediction models for noncardiac surgery patients Rössler, J. Shah, K. Medellin, S. Turan, A. Ruetzler, K. Singh, M. Sessler, D. I. Maheshwari, K. J Pain Palliat Care Pharmacother 2023

Anesthesia
Delirium
Dynamic modeling
Machine learning
Noncardiac surgery
Postoperative
Prediction

Effects of Opioids, Steroids, Benzodiazepines, Anticholinergics, and Antihistamines on the Efficacy of Antipsychotics for Treating Delirium in End-of-Life Adult Patients Undergoing Palliative Care Sato, J. Tanaka, R. J Pain Palliat Care Pharmacother 2023

Humans
Adult
*Antipsychotic Agents/therapeutic use
Benzodiazepines
Palliative Care/methods
Cholinergic Antagonists/therapeutic use
Analgesics, Opioid/therapeutic use
Retrospective Studies
*Delirium/drug therapy
Death
Histamine Antagonists/therapeutic use
Steroids/therapeutic use
Delirium
antipsychotics
opioids
steroids

Clinical Prediction Models for Hospital-Induced Delirium Using Structured and Unstructured Electronic Health Record Data: Protocol for a Development and Validation Study Ser, S. E. Shear, K. Snigurska, U. A. Prosperi, M. Wu, Y. Magoc, T. Bjarnadottir, R. I. Lucero, R. J. JMIR Res Protoc 2023

big data
clinical text
data science
delirium
free text
hospital acquired
hospital induced
hospital-acquired condition
machine learning
model
models
natural language processing
predict
prediction
predictive
risk
risk factors
structured
text data
unstructured

A Prospective Randomized Study of the Herbal Medicine Yokukansan for Preventing Delirium After Gastrointestinal Cancer Surgery Tanio, A. Yamamoto, M. Uejima, C. Tada, Y. Yamanashi, T. Matsuo, R. Miura, A. Kajitani, N. Nishiguchi, T. Iwata, M. Fujiwara, Y. Yonago Acta Med 2023

gastrointestinal cancer
postoperative delirium
yokukansan

A protocol of an international validation study to assess the clinical accuracy of the eDIS-ICU delirium screening tool Tronstad, O. Patterson, S. Sutt, A. L. Pearse, I. Hay, K. Liu, K. Sato, K. Koga, Y. Matsuoka, A. Hongo, T. Rätsep, I. Fraser, J. F. Flaws, D. Aust Crit Care 2023

Humans
*Delirium/diagnosis
Australia
Intensive Care Units
Outcome Assessment, Health Care
New Zealand
Delirium
Delirium assessment
Electronic screening tool
Icu
Research protocol

Anaesthesia-related cognitive dysfunction following cardiothoracic surgery in late middle-age and younger adults: A scoping review Varpaei, H. A. Robbins, L. B. Ling, J. Lehto, R. H. Bender, C. M. Nurs Crit Care 2023

anaesthesia
cardiac
cognitive decline
critical care
delirium

Long-term mortality of critically ill patients with cancer and delirium who survived to discharge: a retrospective cohort study Vizzacchi, B. A. Pezzini, T. R. de Souza, J. M. Caruso, P. Nassar, A. P., Jr. Can J Anaesth 2023

Adult
Humans
Patient Discharge
*Delirium/epidemiology
Retrospective Studies
Critical Illness
Intensive Care Units
Psychomotor Agitation
*Neoplasms/complications
critical care
delirium
long-term care
mortality

The effect of anesthetic depth on postoperative delirium in older adults: a systematic review and meta-analysis Wang, Y. Zhu, H. Xu, F. Ding, Y. Zhao, S. Chen, X. BMC Geriatr 2023

Humans
Middle Aged
Aged
*Emergence Delirium
*Delirium/epidemiology
*Anesthetics
Anesthesia, General/adverse effects
Cognition
Postoperative Complications/etiology
Anesthetic depth
Bis
General anesthesia
Older adults
Postoperative delirium

Unveiling the nexus of postoperative fever and delirium in cardiac surgery: identifying predictors for enhanced patient care Wang, Y. P. Shen, B. B. Zhu, C. C. Li, L. Lu, S. Wang, D. J. Jin, H. Liu, Q. Wang, Z. Y. Ge, M. Front Cardiovasc Med 2023

Cpb
cardiac surgery
fever
postoperative delirium
prediction model

Long-term cognitive impairment after probable delirium in long-term care residents: A population-based retrospective cohort study Webber, C. Milani, C. Pugliese, M. Lawlor, P. G. Bush, S. H. Watt, C. Casey, G. Knoefel, F. Thavorn, K. Momoli, F. Tanuseputro, P. J Am Geriatr Soc 2023

cognitive decline
delirium
long-term care

Delirium Due to Potentially Avoidable Hospitalizations Among Older Adults Whittington, C. Skains, R. M. Zhang, Y. Osborne, J. D. O'Leary, T. Freeman, H. B. Martin, R. C. Vickers, J. K. Flood, K. L. Markland, A. D. Buford, T. W. Brown, C. J. Kennedy, R. E. J Gerontol A Biol Sci Med Sci 2023

ambulatory care sensitive conditions
delirium
older adults
potentially avoidable hospitalizations

Quantitative electroencephalography predicts postoperative delirium in cardiac surgical patients after cardiopulmonary bypass: a prospective observational study Xue, Y. Liu, W. Su, L. He, H. Chen, H. Long, Y. Front Med (Lausanne) 2023

cardiopulmonary bypass
critical care
delirium biomarkers
postoperative delirium
quantitative electroencephalography

Natural language processing to assess the epidemiology of delirium-suggestive behavioural disturbances in critically ill patients Young, M. Holmes, N. Robbins, R. Marhoon, N. Amjad, S. Neto, A. S. Bellomo, R. Crit Care Resusc 2021

Background: There is no gold standard approach for delirium diagnosis, making the assessment of its epidemiology difficult. Delirium can only be inferred though observation of behavioural disturbance and described with relevant nouns or adjectives. Objective: We aimed to use natural language processing (NLP) and its identification of words descriptive of behavioural disturbance to study the epidemiology of delirium in critically ill patients. Study design: Retrospective study using data collected from the electronic health records of a university-affiliated intensive care unit (ICU) in Melbourne, Australia. Participants: 12 375 patients Intervention: Analysis of electronic progress notes. Identification using NLP of at least one of a list of words describing behavioural disturbance within such notes. Results: We analysed 199 648 progress notes in 12 375 patients. Of these, 5108 patients (41.3%) had NLP-diagnosed behavioural disturbance (NLP-Dx-BD). Compared with those who did not have NLP-Dx-DB, these patients were older, more severely ill, and likely to have medical or unplanned admissions, neurological diagnosis, chronic kidney or liver disease and to receive mechanical ventilation and renal replacement therapy (P < 0.001). The unadjusted hospital mortality for NLP-Dx-BD patients was 14.1% versus 9.6% for patients without NLP-Dx-BD. After adjustment for baseline characteristics and illness severity, NLP-Dx-BD was not associated with increased risk of death (odds ratio [OR], 0.94; 95% CI, 0.80-1.10); a finding robust to multiple sensitivity, subgroups and time of observation subcohort analyses. In mechanically ventilated patients, NLP-Dx-BD was associated with decreased hospital mortality (OR, 0.80; 95% CI, 0.65-0.99) after adjustment for baseline severity of illness and year of admission. Conclusions: NLP enabled rapid assessment of large amounts of data identifying a population of ICU patients with typical high risk characteristics for delirium. Moreover, this technique enabled identification of previously poorly understood associations. Further investigations of this technique appear justified.

Association between intraoperative mean arterial pressure variability and postoperative delirium after hip fracture surgery: a retrospective cohort study Zhang, C. Song, Y. Wu, X. Miao, R. Lou, J. Ma, Y. Li, M. Mi, W. Cao, J. BMC Geriatr 2023

Aged
Humans
Aged, 80 and over
*Emergence Delirium
Arterial Pressure
Retrospective Studies
*Hip Fractures/surgery
Multivariate Analysis
Postoperative Complications/diagnosis/epidemiology/etiology
Risk Factors
Hip fracture
Mean arterial pressure variability
Postoperative delirium

Impact of Clinical Decision Support System Assisted prevention and management for Delirium on guideline adherence and cognitive load among Intensive Care Unit nurses (CDSSD-ICU): Protocol of a multicentre, cluster randomized trial Zhang, S. Ding, S. Cui, W. Li, X. Wei, J. Wu, Y. Int J Nurs Stud 2023

Humans
Guideline Adherence
Prospective Studies
Decision Support Systems, Clinical
Delirium/prevention & control/diagnosis
Intensive Care Units
Cognition
Randomized Controlled Trials

Non-pharmacological interventions to prevent and treat delirium in older people: An overview of systematic reviews Zhao, Q. Liu, S. Zhao, H. Dong, L. Zhu, X. Liu, J. Int J Nurs Stud 2023

Humans
Aged
*Delirium/prevention & control
Systematic Reviews as Topic
Risk Factors
Length of Stay
Accidental Falls
Acute confusion
Delirium
Non-pharmacological intervention
Older people

Online interpretable dynamic prediction models for postoperative delirium after cardiac surgery under cardiopulmonary bypass developed based on machine learning algorithms: A retrospective cohort study Zhao, X. Li, J. Xie, X. Fang, Z. Feng, Y. Zhong, Y. Chen, C. Huang, K. Ge, C. Shi, H. Si, Y. Zou, J. J Psychosom Res 2023

Cardiac surgery
Cardiopulmonary bypass
Dynamic prediction
Machine learning
Postoperative delirium
Pre- and post-operative models

Dementia and Postoperative Delirium in Surgical Hip Fracture Patients: Unveiling Contrasting Risk Factors and Implications Zhao, Y. Alderden, J. Missbrenner, N. J Gerontol Nurs 2023

Humans
Aged
*Emergence Delirium
*Hip Fractures/complications/surgery
*Geriatric Nursing
Risk Factors
*Dementia/complications

Diagnostic accuracy of the Family Confusion Assessment Method for delirium detection: A systematic review and meta-analysis Zhou, C. Wang, H. Wang, L. Zhou, Y. Wu, Q. J Am Geriatr Soc 2023

Fam-cam
caregiver
delirium
family
meta-analysis

The effects of a multidisciplinary pathway for perioperative management of patients with hip fracture Ackermann, L. L. Schwenk, E. S. Li, C. J. Vaile, J. R. Weitz, H. Hosp Pract (1995) 2023

Humans, Aged, Analgesics, Opioid/therapeutic use, Prospective Studies
*Hip Fractures/surgery, Pain, Postoperative/drug therapy/chemically induced/complications, Delirium, Hip fracture pathway
delirium, multidisciplinary care, pain management, perioperative hip fracture

Precision-based approaches to delirium in critical illness: A narrative review Ankravs, M. J. McKenzie, C. A. Kenes, M. T. Pharmacotherapy 2023

Humans, Delirium/diagnosis/drug therapy/etiology, Intensive Care Units
Critical Illness, Cognitive Dysfunction, Critical Care, biomarkers, delirium, phenotypes, precision medicine

Associations between early in-hospital medications and the development of delirium in patients with stroke Ryan, S. L. Liu, X. McKenna, V. Ghanta, M. Muniz, C. Renwick, R. Westover, M. B. Kimchi, E. Y. J Stroke Cerebrovasc Dis 2023

Humans
*Antipsychotic Agents/adverse effects
Retrospective Studies
*Delirium/chemically induced/diagnosis
Risk Factors
*Stroke/diagnosis/drug therapy/complications
Hypnotics and Sedatives/therapeutic use
Hospitals
Delirium
Medications
Polypharmacy
Stroke

Family-centered delirium prevention and treatment using video calls: the FACE Delirium trial Trabert, J. Schenk, A. Golbach, R. Püllen, R. Schütze, S. Eur Geriatr Med 2023

Delirium
Family
Pandemic
Prevention
Video calls

Early Onset Delirium During Hospitalization Increases In-Hospital and Postdischarge Mortality in COVID-19 Patients: A Multicenter Prospective Study Trevisan, C. Grande, G. Rebora, P. Zucchelli, A. Valsecchi, M. G. Focà, E. Ecarnot, F. Marengoni, A. Bellelli, G. J Clin Psychiatry 2023

Humans
Aged
Prospective Studies
Aftercare
*covid-19
Patient Discharge
Hospitalization
Hospitals
*Delirium

Accuracy of a clinical decision support system based on the 3-minute diagnostic interview for CAM-defined delirium: A validation study(✰) Wang, J. Ji, M. Huang, Y. Yang, F. Wu, Y. Geriatr Nurs 2023

Humans
Aged
*Delirium/diagnosis
*Decision Support Systems, Clinical
Sensitivity and Specificity
*Cognitive Dysfunction
Reproducibility of Results
Clinical decision support system
Delirium
Older adult
Validation
declare.

Psychological stress and associated factors in caring for patients with delirium among intensive care unit nurses: A cross-sectional study Wang, Y. Li, L. Tan, S. Guan, Y. Luo, X. Aust Crit Care 2023

Humans
Cross-Sectional Studies
Stress, Psychological/psychology
Intensive Care Units
*Nurse Administrators
*Delirium
Patient Care
Surveys and Questionnaires
*Nurses
Delirium
ICU nurses
Nursing
Psychological stress

Inflammatory biomarkers and delirium: a Mendelian randomization study Yu, M. Li, Y. Li, B. Ge, Q. Front Aging Neurosci 2023

Il-6
Mendelian randomization
delirium
inflammatory markers
summary genome-wide association study

 

Knowledge, attitude and practice regarding hypoactive delirium among ICU nurses: A nationwide cross-sectional study Yu, M. Mi, J. Zhang, C. Chen, H. Luo, X. Nurse Educ Pract 2023

Attitude
Delirium subtype
Hypoactive delirium
ICU nurse
Knowledge
Practice
competing financial interests or personal relationships that could have appeared
to influence the work reported in this paper.

Potentials of Acetylcholinesterase and Butyrylcholinesterase Alterations in On-Pump Coronary Artery Bypass Surgery in Postoperative Delirium: An Observational Trial Zajonz, T. S. Kunzemann, C. Schreiner, A. L. Beckert, F. Schneck, E. Boening, A. Markmann, M. Sander, M. Koch, C. J Clin Med 2023

cardiac surgery
cardiopulmonary bypass
intensive care
postoperative care
postoperative delirium
preoperative patient evaluation and improvement

Peripheral cholinesterase activity is not correlated with postoperative delirium in urological surgery Zangl, Q. Sprinz, B. von Dossow, V. J Perioper Pract 2023

Acetylcholinesterase
Butyrylcholinesterase
Pocd
Pod
Postoperative cognitive deficite
Postoperatvie delirium
Surgery

Biologic correlates associated with poor functional recovery after delirium: A nested prospective cohort study Dasgupta, M. Brymer, C. Health Sci Rep 2023

activities of daily living
aged
delirium
prognosis

ICU Delirium Is Associated with Cardiovascular Burden and Higher Mortality in Patients with Severe COVID-19 Pneumonia Gutowski, M. Klimkiewicz, J. Michałowski, A. Ordak, M. Możański, M. Lubas, A. J Clin Med 2023

Covid-19
Icu
delirium

Analysis of risk factors for postoperative delirium in middle-aged and elderly fracture patients in the perioperative period An, Z. Xiao, L. Chen, C. Wu, L. Wei, H. Zhang, X. Dong, L. Sci Rep 2023

Aged
Humans
Middle Aged
*Emergence Delirium/epidemiology/etiology
Blood Loss, Surgical
*Delirium/etiology/complications
Postoperative Complications/epidemiology/etiology
*Hip Fractures/surgery/complications
Perioperative Period/adverse effects
Anesthesia, General/adverse effects
Risk Factors

Korkatti-Puoskari, N. Tiihonen, M. Caballero-Mora, M. A. Topinkova, E. Szczerbińska, K. Hartikainen, S. Therapeutic dilemma's: antipsychotics use for neuropsychiatric symptoms of dementia, delirium and insomnia and risk of falling in older adults, a clinical review Eur Geriatr Med 2023

Humans
Aged
*Antipsychotic Agents/adverse effects
Accidental Falls/prevention & control
*Sleep Initiation and Maintenance Disorders/chemically induced/drug therapy
*Dementia/drug therapy/chemically induced
*Delirium/chemically induced/drug therapy
Antipsychotics
Delirium
Dementia
Falls
Insomnia
Older adults

The efficacy and safety of haloperidol for the treatment of delirium in critically ill patients: a systematic review and meta-analysis of randomized controlled trials Huang, J. Zheng, H. Zhu, X. Zhang, K. Ping, X. Front Med (Lausanne) 2023

Icu
critically ill adult patients
delirium
haloperidol
meta-analysis
commercial or financial relationships that could be construed as a potential
conflict of interest.

A prospective randomized study examining the impact of intravenous versus inhalational anesthesia on postoperative cognitive decline and delirium Farrer, T. J. Monk, T. G. McDonagh, D. L. Martin, G. Pieper, C. F. Koltai, D. Appl Neuropsychol Adult 2023

Anesthesia type
Pocd
cognition
older adults

Factors Associated with Improvement in Activities of Daily Living during Hospitalization: A Retrospective Study of Older Patients with Hip Fractures Takeda, K. Wada, M. Yorozuya, K. Hara, Y. Watanabe, T. Hanaoka, H. Ann Geriatr Med Res 2023

Activities of daily living
Apathy
Behavioral symptoms
Delirium
Dementia
Hip fractures

Associations Between Dysphagia and Adverse Health Outcomes in Older Adults with Dementia in Intensive Care Units: A Retrospective Cohort Study Cheng, H. Deng, X. Li, J. Tang, Y. Yuan, S. Huang, X. Wang, Z. Zhou, F. Lyu, J. Clin Interv Aging 2023

Humans
Female
Aged
Aged, 80 and over
Male
Retrospective Studies
*Pressure Ulcer
Intensive Care Units
*Deglutition Disorders/epidemiology/diagnosis
*Pneumonia, Aspiration/etiology/complications
*Delirium/epidemiology
*Dementia/complications/epidemiology
Outcome Assessment, Health Care
delirium
dementia
dysphagia
intensive care unit
mortality
older adults

Microvascular reconstruction for oral cancer in older adult patients: the impact of age on surgical outcomes Kouketsu, A. Kaneuji, T. Yamaguma, Y. Yamauchi, K. Sugiura, T. Takahashi, T. Ito, H. Yamashita, Y. Oral Surg Oral Med Oral Pathol Oral Radiol 2023

oral, cancer, surgical, adults, elderly

Postoperative delirium is a risk factor of institutionalization after hip fracture: an observational cohort study Labaste, F. Delort, F. Ferré, F. Bounes, F. Reina, N. Valet, P. Dray, C. Minville, V. Front Med (Lausanne) 2023

delirium
dependence
hip fracture
institutionalization
orthopedic surgery
commercial or financial relationships that could be construed as a potential
conflict of interest.

Prognostic significance of delirium in patients with heart failure: a systematic review and meta-analysis Niu, Z. Zhou, J. Li, Y. Front Cardiovasc Med 2023

delirium
heart failure
hospitalization
meta-analysis
mortality

Postoperative delirium in 47 379 individuals undergoing transcatheter aortic valve replacement: a systematic review and meta-analysis Ochani, S. Adnan, A. Siddiqui, A. Kalwar, A. Kukreja, S. Ahmad, M. Ashraf, M. H. Asghar, M. A. Ann Med Surg (Lond) 2023

Cam, Tavr, confusion assessment method, delirium, stroke, transcatheter aortic valve replacement

ICU Readmission in Injured Older Adults: Modifiable Risk Factors and Implications Agoubi, L. L. Reimel, B. A. Maine, R. G. O'Connell, K. M. Maier, R. V. McIntyre, L. K. J Trauma Acute Care Surg 2023

ICU, delirium, older adults, risk factors, readmission

Motorist disorientation syndrome; clinical features and vestibular findings Ainsworth, C. Davies, R. Colvin, I. Murdin, L. J Vestib Res 2023

Humans
Female
Adult
Dizziness/diagnosis/etiology
Vertigo/diagnosis
*Vestibular Diseases/diagnosis
Confusion/diagnosis
*Migraine Disorders
Motorist Disorientation Syndrome (MDS)

External validity of an automated delirium prediction model (DEMO) and comparison to the manual VMS-questions: a retrospective cohort study Ali, M. I. M. Kalkman, G. A. Wijers, C. H. W. Fleuren, Hwha Kramers, C. de Wit, Hajm Int J Clin Pharm 2023

Humans
Retrospective Studies
*Hospitalization
Hospitals
*Delirium/diagnosis/epidemiology/prevention & control
Automated model
Delirium
External validation
Hospitalized patients
Prevention measures
Risk prediction

Role of Intraoperative Neuromonitoring to Predict Postoperative Delirium in Cardiovascular Surgery Al-Qudah, A. M. Ta'ani, O. A. Thirumala, P. D. Sultan, I. Visweswaran, S. Nadkarni, N. Kiselevskaya, V. Crammond, D. J. Balzer, J. Anetakis, K. M. Shandal, V. Subramanium, K. Subramanium, B. Sadhasivam, S. J Cardiothorac Vasc Anesth 2023

Eeg, Ionm, Ssep, cardiac, delirium, postoperative

Comparison of the hemodynamic effects of opioid-based versus lidocaine-based induction of anesthesia with propofol in older adults: a randomized controlled trial Amin, S. M. Hasanin, A. ElSayed, O. S. Mostafa, M. Khaled, D. Arafa, A. S. Hassan, A. Anaesth Crit Care Pain Med 2023

Humans
Aged
*Propofol/adverse effects
Lidocaine
Analgesics, Opioid/therapeutic use
Anesthetics, Intravenous
*Emergence Delirium
Fentanyl
Hemodynamics
Anesthesia, General
*Hypotension/chemically induced/epidemiology
Norepinephrine/therapeutic use
General anesthesia
Hypotension
Older adult
Propofol

Effect of pharmacist-led intervention protocol on preventing postoperative delirium after elective cardiovascular surgery Asai, Y. Yanagawa, T. Takahashi, M. PLoS One 2023

Adult, Humans, *Emergence Delirium, Pharmacists, Retrospective Studies, Benzodiazepines/adverse effects

Taming Postoperative Delirium with Dexmedetomidine: A Review of the Therapeutic Agent's Neuroprotective Effects following Surgery Bargnes, V., 3rd Oliver, B. Wang, E. Greenspan, S. Jin, Z. Yeung, I. Bergese, S. Pharmaceuticals (Basel) 2023

dexmedetomidine
neuroprotection
perioperative neurocognitive disorder
postoperative delirium

Level of implementation of pain management and early mobilization strategies to prevent delirium in geriatric trauma patients: A mixed-methods study Beaudoin, M. Belzile, E. L. Gélinas, C. Trépanier, D. Émond, M. Gagnon, M. A. Bérubé, M. Int J Orthop Trauma Nurs 2023

Delirium, Early mobilization, Geriatric trauma, Mixed-methods, Pain management, Practice guidelines

Dose-dependent QTc interval prolongation under haloperidol and pipamperone in the management of delirium in a naturalistic setting Bohny, P. Boettger, S. Jenewein, J. Front Psychiatry 2023

QTc interval, delirium, haloperidol, pipamperone, torsades de pointes

Prevalence and risk factors of subsyndromal delirium among postoperative patients: A systematic review and meta-analysis Chen, S. Tang, L. Chen, J. Cai, L. Liu, C. Song, J. Chen, Y. Liu, Y. Zheng, S. J Adv Nurs 2023

Subsyndromal delirium, meta-analysis, nurse, nursing, postoperative care, prevalence, risk factors, surgery

Incidence change of postoperative delirium after implementation of processed electroencephalography monitoring during surgery: a retrospective evaluation study Chen, Y. C. Hung, I. Y. Hung, K. C. Chang, Y. J. Chu, C. C. Chen, J. Y. Ho, C. H. Yu, C. H. BMC Anesthesiol 2023

Humans
Aged
*Emergence Delirium/diagnosis/epidemiology/complications
Postoperative Complications/diagnosis/epidemiology/prevention & control
Incidence
Retrospective Studies
*Delirium/diagnosis/epidemiology/etiology
Anesthesia, General/adverse effects/methods
Electroencephalography
General anesthesia
Intravenous patient-controlled analgesia
Postoperative delirium
Processed electroencephalography

Incidence and risk factors for postoperative delirium after head and neck cancer surgery: an updated meta-analysis Dong, B. Yu, D. Jiang, L. Liu, M. Li, J. BMC Neurol 2023

Humans
Male
Aged
*Emergence Delirium/complications/epidemiology/prevention & control
*Delirium/epidemiology/etiology
Postoperative Complications/etiology
Incidence
Risk Factors
*Head and Neck Neoplasms/epidemiology/surgery
Head and neck cancer
Meta-analysis
Postoperative delirium
Systematic review

Five-year stroke prognosis. Influence of post-stroke delirium and post-stroke dementia on mortality and disability (Research Study - Part of the PROPOLIS Study) Droś, J. Segiet, N. Początek, G. Klimkowicz-Mrowiec, A. Neurol Sci 2023

Cognition disorders, Delirium, Dementia, Mortality, Stroke

Comparison of continuous sedatives in the burn ICU on delirium and coma Falksen, J. Young, S. R. Lee, J. A. J Burn Care Res 2023

burn, coma, delirium, sedation

Associations between depression symptom burden and delirium risk: a prospective cohort study Gaba, A. Li, P. Xi, Z. Gao, C. Ruixue, C. Hu, K. Gao, L. medRxiv 2023

Altered mental status
Alzheimer’s disease
anxiety
dementia
postoperative

Delirium and Previous Psychiatric History Independently Predict Poststroke Posttraumatic Stress Disorder Griffin, T. T. Bhave, V. McNulty, J. Christophe, B. R. Garton, A. L. A. Sander Connolly, E., Jr. Neurologist 2023

Humans, Female, *Stress Disorders, Post Traumatic/epidemiology/etiology/diagnosis, *Stroke/complications/epidemiology, *Delirium/diagnosis/epidemiology/etiology

Incidence of Postoperative Delirium in Cancer Patients After Head and Neck Surgery: A Proportional Meta-analysis Ho, M. H. Li, P. W. C. Lin, Y. K. Lee, J. J. Lin, C. C. Otolaryngol Head Neck Surg 2023

cancer, delirium, head and neck cancer, incidence, postoperative, proportional Meta-analysis

Triglyceride-glucose index as a valuable predictor for aged 65-years and above in critical delirium patients: evidence from a multi-center study Huang, X. Cheng, H. Yuan, S. Ling, Y. Tan, S. Tang, Y. Niu, C. Lyu, J. BMC Geriatr 2023

Humans
*Critical Care
Databases, Factual
Glucose
Triglycerides
*Delirium/diagnosis/epidemiology
Blood Glucose
Biomarkers
Risk Factors
Critical care
Delirium
Insulin resistance
Older adults
Triglyceride glucose index

Reliability and Validity of the Spanish Adaptation of the Stanford Proxy Test for Delirium in 2 Clinical Spanish-Speaking Communities Infante, S. Behn, A. González, M. Pintor, L. Franco, E. Araya, P. Maldonado, J. R. J Acad Consult Liaison Psychiatry 2023

Stanford proxy test for delirium, confusion assessment method, delirium, delirium and COVID, factor analysis

Association between preoperative neutrophil-lymphocyte ratio, uric acid, and postoperative delirium in elderly patients undergoing degenerative spine surgery Kato, K. Kinoshita, H. Kumagai, G. Takekawa, D. Nitobe, Y. Asari, T. Wada, K. Kushikata, T. Ishibashi, Y. Hirota, K. J Anesth 2023

Neuroprotection, Neutrophil–lymphocyte ratio, Postoperative delirium, Spine surgery, Uric acid

Preoperative assessment of postoperative delirium: a cross-sectional study of patients and anesthesiologists in Canada Khaled, M. Youssef, N. Choi, S. Uppal, V. Chui, J. Marcucci, M. Madden, K. Shanthanna, H. Can J Anaesth 2023

Humans
Male
Aged
Female
*Emergence Delirium
Cross-Sectional Studies
Anesthesiologists
*Delirium/diagnosis/epidemiology/complications
Canada
Risk Factors
Postoperative Complications/etiology
older adults
postoperative delirium
preoperative screening
risk reduction
shared decision-making

Resting-state prefrontal EEG biomarker in correlation with postoperative delirium in elderly patients Kim, J. Park, S. Kim, K. N. Ha, Y. Shin, S. J. Cha, W. Lee, K. Y. Choi, J. Koo, B. N. Front Aging Neurosci 2023

elderly, electroencephalography, median dominant frequency, postoperative complications, postoperative delirium

Risk of delirium with antiepileptic drug use: a study based on the Japanese Adverse Drug Event Report database Kubo, T. Sogawa, R. Tsuruhashi, S. Murakawa-Hirachi, T. Matsuoka, A. Mizoguchi, Y. Monji, A. Shimanoe, C. Int J Clin Pharm 2023

Humans
Anticonvulsants/adverse effects
Receptors, GABA-A
East Asian People
*Drug-Related Side Effects and Adverse Reactions
*Delirium/chemically induced/epidemiology/drug therapy
Adverse event
Antiepileptic drugs
Database
Delirium