What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.
- Authors
- Miller, D. Lewis, S. R. Pritchard, M. W. Schofield-Robinson, O. J. Shelton, C. L. Alderson, P. Smith, A. F.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
BACKGROUND: The use of anaesthetics in the elderly surgical population (more than 60 years of age) is increasing. Postoperative delirium, an acute condition characterized by reduced awareness of the environment and a disturbance in attention, typically occurs between 24 and 72 hours after surgery and can affect up to 60% of elderly surgical patients. Postoperative cognitive dysfunction (POCD) is a new-onset of cognitive impairment which may persist for weeks or months after surgery.Traditionally, surgical anaesthesia has been maintained with inhalational agents. End-tidal concentrations require adjustment to balance the risks of accidental awareness and excessive dosing in elderly people. As an alternative, propofol-based total intravenous anaesthesia (TIVA) offers a more rapid recovery and reduces postoperative nausea and vomiting. Using TIVA with a target controlled infusion (TCI) allows plasma and effect-site concentrations to be calculated using an algorithm based on age, gender, weight and height of the patient.TIVA is a viable alternative to inhalational maintenance agents for surgical anaesthesia in elderly people. However, in terms of postoperative cognitive outcomes, the optimal technique is unknown. OBJECTIVES: To compare maintenance of general anaesthesia for elderly people undergoing non-cardiac surgery using propofol-based TIVA or inhalational anaesthesia on postoperative cognitive function, mortality, risk of hypotension, length of stay in the postanaesthesia care unit (PACU), and hospital stay. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2017, Issue 11), MEDLINE (1946 to November 2017), Embase (1974 to November 2017), PsycINFO (1887 to November 2017). We searched clinical trials registers for ongoing studies, and conducted backward and forward citation searching of relevant articles. SELECTION CRITERIA: We included randomized controlled trials (RCTs) with participants over 60 years of age scheduled for non-cardiac surgery under general anaesthesia. We planned to also include quasi-randomized trials. We compared maintenance of anaesthesia with propofol-based TIVA versus inhalational maintenance of anaesthesia. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed studies for inclusion, extracted data, assessed risk of bias, and synthesized findings. MAIN RESULTS: We included 28 RCTs with 4507 randomized participants undergoing different types of surgery (predominantly cardiovascular, laparoscopic, abdominal, orthopaedic and ophthalmic procedures). We found no quasi-randomized trials. Four studies are awaiting classification because we had insufficient information to assess eligibility.All studies compared maintenance with propofol-based TIVA versus inhalational maintenance of anaesthesia. Six studies were multi-arm and included additional TIVA groups, additional inhalational maintenance or both. Inhalational maintenance agents included sevoflurane (19 studies), isoflurane (eight studies), and desflurane (three studies), and was not specified in one study (reported as an abstract). Some studies also reported use of epidural analgesia/anaesthesia, fentanyl and remifentanil.We found insufficient reporting of randomization methods in many studies and all studies were at high risk of performance bias because it was not feasible to blind anaesthetists to study groups. Thirteen studies described blinding of outcome assessors. Three studies had a high of risk of attrition bias, and we noted differences in the use of analgesics between groups in six studies, and differences in baseline characteristics in five studies. Few studies reported clinical trials registration, which prevented assessment of risk of selective reporting bias.We found no evidence of a difference in incidences of postoperative delirium according to type of anaesthetic maintenance agents (odds ratio (OR) 0.59, 95% confidence interval (CI) 0.15 to 2.26; 321 participants; five studies; very low-certainty evidence); we noted during sensitivity analysis that using different time points in one study may influence direction of this result. Thirteen studies (3215 participants) reported POCD, and of these, six studies reported data that could not be pooled; we noted no difference in scores of POCD in four of these and in one study, data were at a time point incomparable to other studies. We excluded one large study from meta-analysis because study investigators had used non-standard anaesthetic management and this study was not methodologically comparable to other studies. We combined data for seven studies and found low-certainty evidence that TIVA may reduce POCD (OR 0.52, 95% CI 0.31 to 0.87; 869 participants).We found no evidence of a difference in mortality at 30 days (OR 1.21, 95% CI 0.33 to 4.45; 271 participants; three studies; very low-certainty evidence). Twelve studies reported intraoperative hypotension. We did not perform meta-analysis for 11 studies for this outcome. We noted visual inconsistencies in these data, which may be explained by possible variation in clinical management and medication used to manage hypotension in each study (downgraded to low-certainty evidence); one study reported data in a format that could not be combined and we noted little or no difference between groups in intraoperative hypotension for this study. Eight studies reported length of stay in the PACU, and we did not perform meta-analysis for seven studies. We noted visual inconsistencies in these data, which may be explained by possible differences in definition of time points for this outcome (downgraded to very low-certainty evidence); data were unclearly reported in one study. We found no evidence of a difference in length of hospital stay according to type of anaesthetic maintenance agent (mean difference (MD) 0 days, 95% CI -1.32 to 1.32; 175 participants; four studies; very low-certainty evidence).We used the GRADE approach to downgrade the certainty of the evidence for each outcome. Reasons for downgrading included: study limitations, because some included studies insufficiently reported randomization methods, had high attrition bias, or high risk of selective reporting bias; imprecision, because we found few studies; inconsistency, because we noted heterogeneity across studies. AUTHORS’ CONCLUSIONS: We are uncertain whether maintenance with propofol-based TIVA or with inhalational agents affect incidences of postoperative delirium, mortality, or length of hospital stay because certainty of the evidence was very low. We found low-certainty evidence that maintenance with propofol-based TIVA may reduce POCD. We were unable to perform meta-analysis for intraoperative hypotension or length of stay in the PACU because of heterogeneity between studies. We identified 11 ongoing studies from clinical trials register searches; inclusion of these studies in future review updates may provide more certainty for the review outcomes.
- PMID
- Keywords
Aged
Anesthesia, Inhalation
Anesthesia, Intravenous
Anesthetics, Inhalation
Anesthetics, Intravenous/*adverse effects
Cognition/*drug effects
Cognition Disorders/chemically induced
Delirium/chemically induced
Desflurane
Humans
Hypotension/chemically induced
Isoflurane/adverse effects/analogs & derivatives
Methyl Ethers/adverse effects
Middle Aged
Postoperative Complications/chemically induced/mortality
Propofol/*adverse effects
Randomized Controlled Trials as Topic
Sevoflurane
*Surgical Procedures, Operative
- Page(s)
- Volume
- 8
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Randomized feasibility trial for evaluating the impact of primary nursing on delirium duration during intensive care unit stay | Krüger, L. Zittermann, A. Mannebach, T. Wefer, F. Becker, T. Lohmeier, S. Lüttermann, A. von Dossow, V. Rojas, S. V. Gummert, J. Langer, G. | Intensive Crit Care Nurs | 2024 |
Delirium |
| Patient recall of intensive care delirium: A qualitative investigation | la Cour, K. N. Andersen-Ranberg, N. C. Mortensen, C. Poulsen, L. M. Mathiesen, O. Egerod, I. Collet, M. | Acta Anaesthesiol Scand | 2024 |
critical care |
| Sevoflurane multiple Wash In/Wash Out at the end of anesthesia to reduce agitation: A multicenter double-blind randomized controlled trial | Landoni, G. Likhvantsev, V. V. Berikashvili, L. B. Yavorovsky, A. G. Bagdasarov, P. S. Smirnova, A. V. Serkova, T. S. Subbotin, V. V. Kadantseva, K. K. Ovezov, A. M. Yadgarov, M. Y. Yakovlev, A. A. Lamacchia, A. Gallo, L. Gracheva, N. D. Ryzhkov, P. V. Zi | Contemp Clin Trials Commun | 2024 |
Anesthesia |
| Predictive model and discriminant analysis of the development of dementia in patients with delirium in the emergency department | Lupiáñez Seoane, P. Muñoz Negro, J. E. Torres Parejo, U. Gómez Jiménez, F. J. | Semergen | 2024 |
Comorbidity |
| Machine learning for the prediction of delirium in elderly intensive care unit patients | Ma, R. Zhao, J. Wen, Z. Qin, Y. Yu, Z. Yuan, J. Zhang, Y. Wang, A. Li, C. Li, H. Chen, Y. Han, F. Zhao, Y. Sun, S. Ning, X. | Eur Geriatr Med | 2024 |
Delirium |
| A Novel Preoperative Electroencephalogram-Derived Index to Predict Early Postoperative Delirium in Elderly Patients After Hip Fracture Surgeries: Development of a Prediction Model | Nawan, A. Wang, G. Zhao, C. Zhang, W. Jiang, B. Feng, Y. | Geriatr Orthop Surg Rehabil | 2024 |
delirium index |
| Fixed dose ketamine for prehospital management of hyperactive delirium with severe agitation | O'Brien, M. C. Kelleran, K. J. Burnett, S. J. Hausrath, K. A. Kneer, M. S. Nan, N. Ma, C. X. McCartin, R. W. Clemency, B. M. | Am J Emerg Med | 2024 |
Humans |
| Platelet Bioenergetics and Associations With Delirium and Coma in Patients With Sepsis: A Prospective Cohort Study | Onyemekwu, C. A. Prendergast, N. T. Potter, K. M. Toney, N. A. Nouraie, M. S. Shiva, S. Girard, T. D. | CHEST Crit Care | 2024 |
acute brain dysfunction |
| Enhancing European Management of Analgesia, Sedation, and Delirium: A Multinational, Prospective, Interventional Before-After Trial | Paul, N. Grunow, J. J. Rosenthal, M. Spies, C. D. Page, V. J. Hanison, J. Patel, B. Rosenberg, A. von Haken, R. Pietsch, U. Schrag, C. Waydhas, C. Schellongowski, P. Lobmeyr, E. Sander, M. Piper, S. K. Conway, D. Totzeck, A. Weiss, B. | Neurocrit Care | 2024 |
Humans |
| EEG and acute confusional state at the emergency department | Prud'hon, S. Amiel, H. Zanin, A. Revue, E. Kubis, N. Lozeron, P. | Neurophysiol Clin | 2024 |
Humans |
| Preoperative Delirium Risk Screening in Patients Undergoing a Cardiac Surgery: Results from the Prospective Observational FINDERI Study | Sadlonova, M. Hansen, N. Esselmann, H. Celano, C. M. Derad, C. Asendorf, T. Chebbok, M. Heinemann, S. Wiesent, A. Schmitz, J. Bauer, F. E. Ehrentraut, J. Kutschka, I. Wiltfang, J. Baraki, H. von Arnim, C. A. F. | Am J Geriatr Psychiatry | 2024 |
Humans |
| Predicting postoperative delirium after percutaneous transluminal angioplasty and stenting in patients with intracranial atherosclerotic stenosis | Zhu, W. Shen, Y. Zhao, H. Tang, Y. Wang, X. Li, S. | Neurol Res | 2024 |
Postoperative delirium |
| Factors contributing to sepsis-associated encephalopathy: a comprehensive systematic review and meta-analysis | Zhang, Z. Guo, L. Jia, L. Duo, H. Shen, L. Zhao, H. | Front Med (Lausanne) | 2024 |
delirium |
| Impact of delirium intervention on cognitive load among nurses in the intensive care unit: A multi-centre cluster randomized controlled trial | Zhang, S. Ji, M. Cui, W. Wei, J. Ding, S. Wu, Y. | Int J Nurs Pract | 2024 |
Humans |
| Incidence and risk factors of post-operative delirium in glioma patients: A prospective cohort study in general wards | Yuan, C. Cheng, Z. Liu, Y. You, Y. Wang, L. Li, D. Zhong, L. | J Clin Nurs | 2024 |
general ward |
| Effect of Morphine Used to Relieve Dyspnea Due to Heart Failure on Delirium | Yoshikai, S. Ueda, M. Ikeda, K. | J Palliat Med | 2024 |
delirium |
| Association of Delirium with Long-Term Mortality in Critically Ill Patients with COPD Who Survived to Discharge: A Retrospective Cohort Study | Xu, H. B. Xue, F. Ye, Y. Zhang, H. G. | Lung | 2024 |
Copd |
| Effect of obstructive sleep apnea on postoperative delirium: a system review and meta-analysis | Xiao, Y. Li, P. J. Guo, M. Y. Cao, Y. Liang, Z. A. | Sleep Breath | 2024 |
Delirium |
| A qualitative study of geriatric specialist nurses' experiences to navigate delirium in the elderly | Wu, M. Chen, Z. Xu, Y. Zhao, L. Zhao, L. Xia, L. | BMC Nurs | 2024 |
Care |
| The influence of low-dose s-ketamine on postoperative delirium and cognitive function in older adults undergoing thoracic surgery | Wang, Y. Ma, B. Wang, C. Wang, Y. Liu, A. Hang, L. | J Cardiothorac Surg | 2024 |
Humans |
| Neurological diagnostic tests for patients with and without delirium: a prospective observational study | Waefler, N. Abid, I. Montaut, V. Donzé, J. Zender, H. John, G. | Geroscience | 2024 |
CT scan |
| Preoperative cognitive function as a risk factor of postoperative delirium in cancer surgeries: A systematic review and meta-analysis | Varpaei, H. A. Robbins, L. B. Farhadi, K. Bender, C. M. | J Surg Oncol | 2024 |
cancer survivors |
| Role of oral melatonin in prevention of postoperative delirium in patients undergoing elective surgery under general anesthesia: A Randomized controlled trial | Thakur, T. Saini, V. Grover, S. Samra, T. | Indian J Psychiatry | 2024 |
Anxiety |
| Clinical characteristics of delirium in older patients with first-ever acute myocardial infarction who underwent percutaneous coronary intervention : A retrospective study | Tan, J. F. Duan, L. Han, J. C. Cui, J. J. | Herz | 2024 |
Acute myocardial infarction |
| Antibiotics for delirium in older adults with pyuria or bacteriuria: A systematic review | Stall, N. M. Kandel, C. Reppas-Rindlisbacher, C. Quinn, K. L. Wiesenfeld, L. MacFadden, D. R. Johnstone, J. Fralick, M. | J Am Geriatr Soc | 2024 |
antibiotics |
| Establishment and validation of the prediction model for postoperative delirium risk factors in older patients after total knee arthroplasty: A retrospective study | Song, L. X. Qin, Y. Yang, L. Xing, D. B. Li, Y. Lei, F. Q. Wang, L. H. | Medicine (Baltimore) | 2024 |
Humans |
| Predictive value of the Naples prognostic score on postoperative delirium in the elderly with gastrointestinal tumors: a retrospective cohort study | Song, C. Yu, D. Li, Y. Liu, M. Zhang, H. He, J. Li, J. | BMC Geriatr | 2024 |
Humans |
| Effect of prophylactic corticosteroids on postoperative neurocognitive dysfunction in the adult population: An updated systematic review, meta-analysis, and trial sequential analysis of randomised controlled trials | Singh, N. P. Makkar, J. K. Goel, N. Karamchandani, K. Singh, M. Singh, P. M. | Indian J Anaesth | 2024 |
Corticosteroids |
| Usefulness of the 4A's test for detecting delirium in critically ill patients: a multicenter prospective observation study | Sim, J. K. Chung, K. Chung, C. R. Lee, J. Hwang, S. Y. Lee, Y. S. | Intern Emerg Med | 2024 |
Critical illness |
| Incidence of Postoperative Delirium among Elderly Patients after Elective Surgeries under Anesthesia in the Charity Services of the Philippine General Hospital | Hermoso, R. M. L. Cruz, P. L. O. | Acta Med Philipp | 2024 |
elderly |
| Registered nurses' experiences of caring for patients with hypoactive delirium after cardiac surgery - A qualitative study | Hallberg Kristensen, A. Nymark, C. Stenman, M. Falk, A. | Intensive Crit Care Nurs | 2024 |
Cardiac surgical procedures |
| Determinants of delirium in elderly in-patients in a general ward setting in a teaching hospital: A case control study | Geetha, J. Babu, H. George, C. | Ind Psychiatry J | 2024 |
Delirium |
| Incidence and risk factors of delirium following brain tumor resection: A retrospective National Inpatient Sample database study | Fu, W. Li, Y. Liu, R. Li, J. | World Neurosurg | 2024 |
Brain tumor |
| Prolonged hourly neurological examinations are associated with increased delirium and no discernible benefit in mild/moderate geriatric traumatic brain injury | Fonseca, R. A. Canas, M. Diaz, L. Aldana, J. A. Afzal, H. De Filippis, A. Del Toro, D. Day, A. McCarthy, J. Stansfield, K. Bochicchio, G. V. Niziolek, G. Kranker, L. M. Rosengart, M. R. Hoofnagle, M. Leonard, J. | J Trauma Acute Care Surg | 2024 |
Humans |
| Nursing Intervention to Prevent and Manage Delirium in Critically Ill Patients: A Scoping Review | Fernandes, F. Santos, M. Anacleto, A. M. Jerónimo, C. Ferreira, Ó Baixinho, C. L. | Healthcare (Basel) | 2024 |
adult |
| Intraoperative electroencephalogram features related to frailty in older patients: an exploratory prospective observational study | Fang, P. P. Zhang, H. W. Hao, X. X. Shang, Z. X. Li, J. Liu, X. S. | J Clin Monit Comput | 2024 |
Humans |
| Managing Delirium in the Emergency Department: An Updated Narrative Review | Ehrlich, A. Oh, E. S. Ahmed, S. | Curr Geriatr Rep | 2024 |
Confusion |
| A narrative review of the development and performance characteristics of electronic delirium-screening tools | Eeles, E. Tran, D. D. Boyd, J. Tronstad, O. Teodorczuk, A. Flaws, D. Fraser, J. F. Dissanayaka, N. | Aust Crit Care | 2024 |
*Delirium/diagnosis |
| The Role of Neutrophil-to-Lymphocyte Ratio (NLR) in Urosepsis-Associated Delirium | Dragoescu, A. N. Padureanu, V. Stanculescu, A. D. Chiutu, L. Padureanu, R. Andrei, M. Radu, M. A. Mitroi, G. Dragoescu, P. O. | Cureus | 2024 |
diagnostic |
| Does Melatonin Decrease the Use of As-Needed Antipsychotics or Benzodiazepines in Noncritically Ill Hospitalized Patients? A Multicenter Retrospective Cohort Study | Dobry, P. Poparad-Stezar, A. Bacon, O. Boji, S. Giuliano, C. | J Integr Complement Med | 2024 |
Humans |
| Comparison of the frailty index and frailty phenotype and their associations with postoperative delirium incidence and severity | Deiner, S. G. Marcantonio, E. R. Trivedi, S. Inouye, S. K. Travison, T. G. Schmitt, E. M. Hshieh, T. Fong, T. G. Ngo, L. H. Vasunilashorn, S. M. | J Am Geriatr Soc | 2024 |
Humans |
| Frailty index and risk of delirium in hospitalized patients: a two-sample Mendelian randomization study | Chen, Y. Feng, F. Li, Q. Guo, H. Zhang, L. Liu, J. | Front Med (Lausanne) | 2024 |
Mendelian randomization study |
| Enhancing hospice care with psychological support and a nomogram to predict delirium in patients with advanced solid tumors | Chen, J. Huan, J. Chen, C. Xu, W. Jia, A. | Am J Cancer Res | 2024 |
Hospice care |
| The influence of sleep disorders on perioperative neurocognitive disorders among the elderly: A narrative review | Chen, C. Zhai, R. X. Lan, X. Yang, S. F. Tang, S. J. Xiong, X. L. He, Y. X. Lin, J. F. Feng, J. R. Chen, D. X. Shi, J. | Ibrain | 2024 |
insomnia |
| Prevalence of preoperative depression and adverse outcomes in older patients undergoing elective surgery: A systematic review and meta-analysis | Chen, A. An, E. Yan, E. Saripella, A. Khullar, A. Misati, G. Alhamdah, Y. Englesakis, M. Mah, L. Tartaglia, C. Chung, F. | J Clin Anesth | 2024 |
Delirium, older patients |
| Antipsychotic medications and severe sepsis in schizophrenia: A nested case-control study | Chang, C. W. Chen, W. Y. Chen, P. Y. Pan, C. H. Su, S. S. Tsai, S. Y. Chen, C. C. Kuo, C. J. | Aust N Z J Psychiatry | 2024 |
Sepsis |
| Selection of knowledge translation strategies to implement best practices on nonpharmacological prevention of delirium in intensive care unit | Boivin, A. Bérubé, M. | Rech Soins Infirm | 2024 |
Humans |
| Barriers to healthcare professionals recognizing and managing delirium in older adults during a hospital stay: A mixed-methods systematic review | Bianchi, L. A. Harris, R. Fitzpatrick, J. M. | J Adv Nurs | 2024 |
Humans |
| Burden of delirium on mortality and healthcare resource utilization in geriatric patients hospitalized for inflammatory bowel disease | Aldiabat, M. Aleyadeh, W. Rana, T. Ta'ani, O. A. Alahmad, M. Ayoub, M. Jaber, F. Obeidat, A. Numan, L. Manvar, A. Alhuneafat, L. | Proc (Bayl Univ Med Cent) | 2024 |
Geriatrics |
| Prophylactic Minocycline for Delirium in Critically Ill Patients: A Randomized Controlled Trial | Dal-Pizzol, F. Coelho, A. Simon, C. S. Michels, M. Corneo, E. Jeremias, A. Damásio, D. Ritter, C. | Chest | 2024 |
Humans |
| Clinical Significance of the Prognostic Nutritional Index in Predicting Delirium among Critically Ill Patients: A Retrospective Cohort Study | Xu, F. Zhong, X. | Crit Care Res Pract | 2024 |
Delirium Prognostic Nutrition Index ICU Critically ill patients MIMIC IV |
| Impact of Continuous Infusion Ketamine Compared to Continuous Infusion Benzodiazepines on Delirium in the Intensive Care Unit | Vollmer, N. J. Wieruszewski, E. D. Nei, A. M. Mara, K. C. Rabinstein, A. A. Brown, C. S. | J Intensive Care Med | 2024 |
benzodiazepines |
| Preoperative ketamine administration for prevention of postoperative neurocognitive disorders after major orthopedic surgery in elderly patients: A multicenter randomized blinded placebo-controlled trial | Verdonk, F. Lambert, P. Gakuba, C. Nelson, A. C. Lescot, T. Garnier, F. Constantin, J. M. Saurel, D. Lasocki, S. Rineau, E. Diemunsch, P. Dreyfuss, L. Tavernier, B. Bezu, L. Josserand, J. Mebazaa, A. Coroir, M. Nouette-Gaulain, K. Macouillard, G. Glasman, | Anaesth Crit Care Pain Med | 2024 |
Delayed neurocognitive recovery |
| Dexmedetomidine in Palliative Care: A Versatile New Weapon Against Delirium and Pain-Systematic Review | Tavares, T. Almeida, J. Gonçalves, E. Abelha, F. | J Palliat Med | 2024 |
agitation |
| The Effect of Dexmedetomidine as a Local Anesthetic Adjuvant for Iliac Fascia Compartment Block on Postoperative Delirium in Elderly Patients Undergoing Elective Hip Surgery | Liu, X. H. Zhang, Q. F. Zhang, X. Q. Lu, Q. W. Wu, J. H. Gao, X. H. Chen, Z. Y. | Gerontology | 2024 |
Humans |
| Serum NPTX2 as a Potential Predictive Biomarker for Postoperative Delirium in Patients with Acute Type A Aortic Dissection | Liu, W. Wang, Y. Jiang, Y. Lu, S. Zhu, J. Tian, Y. Pan, J. Xu, Z. Wang, D. | Neuropsychiatr Dis Treat | 2024 |
Nptx2 |
| Incidence and risk factors of postoperative delirium following hepatic resection: a retrospective national inpatient sample database study | Liu, R. Liu, N. Suo, S. Yang, Q. Deng, Z. Fu, W. Wang, M. | BMC Surg | 2024 |
Humans |
| Simplified Pain Management Including Fentanyl TTS in PACU Patients With Hip Fracture Surgery to Improve Patients' Well-Being: A Double-Blind Randomized Trial | Labmayr, V. Rief, M. Reinbacher, P. Gebauer, D. Smigaj, J. Sandner-Kiesling, A. Papamargaritis, V. Michaeli, K. Bornemann-Cimenti, H. Schittek, G. A. | J Perianesth Nurs | 2024 |
Humans |
| Preventive Effects of Ramelteon, Suvorexant, and Lemborexant on Delirium in Hospitalized Patients With Physical Disease: A Retrospective Cohort Study | Henmi, R. Nakamura, T. Mashimoto, M. Takase, F. Ozone, M. | J Clin Psychopharmacol | 2024 |
Sleep-inducing drugs Ramelton Suvorexant Lemborexant Delirium Hospitalized patients |
| Delirium detection in the emergency department: A diagnostic accuracy meta-analysis of history, physical examination, laboratory tests, and screening instruments | Carpenter, C. R. Lee, S. Kennedy, M. Arendts, G. Schnitker, L. Eagles, D. Mooijaart, S. Fowler, S. Doering, M. LaMantia, M. A. Han, J. H. Liu, S. W. | Acad Emerg Med | 2024 |
Geriatrics Delirium Screening accuracy Systematic Review Emergency Department |
| Association of preoperative neutrophil-to-lymphocyte ratio with the risk of postoperative delirium in elderly patients undergoing noncardiac surgery: a systematic review and meta-analysis | Zhou, B. Yu, D. D. Xu, X. Wang, J. Li, J. | Psychogeriatrics | 2024 |
neutrophil |
| Peripheral nerve block and cognitive impairment after thoracic surgery: a systematic review and meta-analysis | Zhang, Y. Liu, M. He, J. Zhang, H. Zhang, M. Li, J. | Minerva Anestesiol | 2024 |
Humans |
| Clinical characteristics of older patients with suspected or diagnosed dementia during hospitalization | Yoshino, H. Takechi, H. | Geriatr Gerontol Int | 2024 |
Humans |
| Development of an individualized model for predicting postoperative delirium in elderly patients with hepatocellular carcinoma | Yan, M. Lin, Z. Zheng, H. Lai, J. Liu, Y. Lin, Z. | Sci Rep | 2024 |
Humans |
| The relationship between intraoperative hypothermia and postoperative delirium: The PNDRFAP study | Wang, J. Zhu, L. Li, C. Lin, Y. Wang, B. Lin, X. Bi, Y. | Brain Behav | 2024 |
Humans |
| Interpretable machine learning model for early prediction of delirium in elderly patients following intensive care unit admission: a derivation and validation study | Tang, D. Ma, C. Xu, Y. | Front Med (Lausanne) | 2024 |
Icu |
| Effects of gabapentin on slow-wave sleep period in critically ill adult patients: A randomized controlled trial | Susantitapong, K. Dilokpattanamongkol, P. Sutherasan, Y. Liamsombut, S. Suthisisang, C. | Clin Transl Sci | 2024 |
Humans |
| Association between postoperative hyperactive delirium and major complications in elderly patients undergoing emergency hip fracture surgery: A large-scale cohort study | Sun, M. Chen, W. M. Wu, S. Y. Zhang, J. | Geriatr Gerontol Int | 2024 |
elderly |
| The 4AT scale for rapid detection of delirium in emergency department triage | Soler-Sanchis, A. Martínez-Arnau, F. M. Sánchez-Frutos, J. Pérez-Ros, P. | Front Med (Lausanne) | 2024 |
aged |
| Efficacy and safety of perioperative melatonin for postoperative delirium in patients undergoing surgery: a systematic review and meta-analysis | Shin, H. W. Kwak, J. S. Choi, Y. J. Kim, J. W. You, H. S. Shin, H. J. Jang, Y. K. | J Int Med Res | 2024 |
*Melatonin/therapeutic use/administration & dosage/adverse effects |
| Characterizing medical patients with delirium: A cohort study comparing ICD-10 codes and a validated chart review method | Sheehan, K. A. Shin, S. Hall, E. Mak, D. Y. F. Lapointe-Shaw, L. Tang, T. Marwaha, S. Gandell, D. Rawal, S. Inouye, S. Verma, A. A. Razak, F. | PLoS One | 2024 |
Humans |
| Postoperative Delirium and Dementia in Patients Undergoing Cardiac Surgery: A Review of Randomized Controlled Trials | Shahabi Raberi, V. Solati Kooshk Qazi, M. Zolfi Gol, A. GhorbaniNia, R. Kahourian, O. Faramarz Zadeh, R. | Galen Med J | 2023 |
Cardiac Surgery |
| The association of hemoglobin with postoperative delirium and atrial fibrillation after cardiac surgery: a retrospective sub-study | Sari, S. Brooker, J. Montalvo-Campana, M. Shehata, P. Pu, X. Insler, S. Ruetzler, K. Troianos, C. A. Turan, A. | Braz J Anesthesiol | 2024 |
Humans |
| A novel objective measure for terminal delirium: Activity scores measured by a sheet-type sensor | Otani, H. Yokomichi, N. Imai, K. Toyota, S. Yamauchi, T. Miwa, S. Yuasa, M. Okamoto, S. Kogure, T. Inoue, S. Morita, T. | J Pain Symptom Manage | 2024 |
Agitation |
| A comparison of changes in drug burden index between older inpatients who fell and people who have not fallen: A case-control study | O'Leary, C. E. T. Wilkinson, T. J. Hanger, H. C. | Australas J Ageing | 2024 |
aged |
| Characterizing Ertapenem Neurotoxicity: A Systematic Review and Experience at a Tertiary Medical Center | Mitaka, H. Hasegawa, S. Lan, K. F. Jain, R. Rakita, R. M. Pottinger, P. S. | Open Forum Infect Dis | 2024 |
carbapenems |
| Prevalence of clinical electroencephalography findings in stroke patients with delirium | Mintz, N. B. Andrews, N. Pan, K. Bessette, E. Asaad, W. F. Sherif, M. Rubinos, C. Mahta, A. Girard, T. D. Reznik, M. E. | Clin Neurophysiol | 2024 |
Humans |
| Development and validation of a nomogram to predict postoperative delirium in older patients after major abdominal surgery: a retrospective case-control study | Luo, Y. G. Wu, X. D. Song, Y. X. Wang, X. L. Liu, K. Shi, C. T. Wang, Z. L. Ma, Y. L. Li, H. Liu, Y. H. Mi, W. D. Lou, J. S. Cao, J. B. | Perioper Med (Lond) | 2024 |
Delirium |
| Relationship Between Coronary Artery Revascularization and Postoperative Delirium: Progress and Perspectives | Lu, N. Chi, Y. Liu, M. | Angiology | 2024 |
cognitive decline |
| Intraoperative electroencephalogram patterns as predictors of postoperative delirium in older patients: a systematic review and meta-analysis | Likhvantsev, V. V. Berikashvili, L. B. Smirnova, A. V. Polyakov, P. A. Yadgarov, M. Y. Gracheva, N. D. Romanova, O. E. Abramova, I. S. Shemetova, M. M. Kuzovlev, A. N. | Front Aging Neurosci | 2024 |
anesthesia |
| Machine learning-based model to predict delirium in patients with advanced cancer treated with palliative care: a multicenter, patient-based registry cohort | Kim, Y. J. Lee, H. Woo, H. G. Lee, S. W. Hong, M. Jung, E. H. Yoo, S. H. Lee, J. Yon, D. K. Kang, B. | Sci Rep | 2024 |
Humans |
| Spinal Anesthesia Reduces Perioperative Polypharmacy and Opioid Burden in Patients Over 65 Who Undergo Transforaminal Lumbar Interbody Fusion | Karimi, H. Patel, J. Olmos, M. Kanter, M. Hernandez, N. S. Silver, R. E. Liu, P. Riesenburger, R. I. Kryzanski, J. | World Neurosurg | 2024 |
Humans |
| Effects of Intranasal Insulin Pretreatment on Preoperative Sleep Quality and Postoperative Delirium in Patients Undergoing Valve Replacement for Rheumatic Heart Disease | Huang, Q. Wu, X. Lei, N. Chen, X. Yu, S. Dai, X. Shi, Q. Gong, G. Shu, H. F. | Nat Sci Sleep | 2024 |
intranasal insulin |
| Association between residential greenness and incident delirium: A prospective cohort study in the UK Biobank | He, Q. Sun, M. Wang, Y. Li, G. Zhao, H. Ma, Z. Feng, Z. Li, T. Han, Q. Sun, N. Li, L. Shen, Y. | Sci Total Environ | 2024 |
Air pollution |
| Effects of Chinese traditional five-element music intervention on postoperative delirium and sleep quality in elderly patients after non-cardiac surgery: a randomized controlled trial | Han, S. Cai, Z. Cao, L. Li, J. Huang, L. | Perioper Med (Lond) | 2024 |
Aged |
| Machine learning with clinical and intraoperative biosignal data for predicting postoperative delirium after cardiac surgery | Han, C. Kim, H. I. Soh, S. Choi, J. W. Song, J. W. Yoon, D. | iScience | 2024 |
Bioinformatics |
| The frequency of sepsis-associated delirium in intensive care unit and its effect on nurse workload | Alıcı, Ş Öztürk Birge, A. | J Clin Nurs | 2024 |
delirium |
| Delirium Knowledge, Risk Factors, and Attitude Among the General Public in Saudi Arabia: A Cross-Sectional Study | Alshurtan, K. Ali Alshammari, F. Alshammari, A. B. Alreheili, S. H. Aljassar, S. Alessa, J. A. Al Yateem, H. A. Almutairi, M. Altamimi, A. F. Altisan, H. A. | Cureus | 2024 |
attitudes |
| The 4AT, a rapid delirium detection tool for use in hospice inpatient units: Findings from a validation study | Arnold, E. Finucane, A. M. Taylor, S. Spiller, J. A. O'Rourke, S. Spenceley, J. Carduff, E. Tieges, Z. MacLullich, A. M. | Palliat Med | 2024 |
Humans |
| The barriers to and facilitators of implementing early mobilisation for patients with delirium on intensive care units: A systematic review | Bennion, J. Manning, C. Mansell, S. K. Garrett, R. Martin, D. | J Intensive Care Soc | 2024 |
Early ambulation |
| Introducing a machine learning algorithm for delirium prediction-the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead) | Benovic, S. Ajlani, A. H. Leinert, C. Fotteler, M. Wolf, D. Steger, F. Kestler, H. Dallmeier, D. Denkinger, M. Eschweiler, G. W. Thomas, C. Kocar, T. D. | Age Ageing | 2024 |
Humans |
| Effect of a fall within three months of admission on delirium in critically Ill elderly patients: a population-based cohort study | Bu, F. Cheng, H. T. Wang, Z. L. Hou, Y. S. Zhuang, Z. Li, C. Y. Wang, Y. Q. Zhang, Y. Lyu, J. Lyu, Q. Y. | Aging Clin Exp Res | 2024 |
Humans |
| Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients | Cavallari, M. Touroutoglou, A. Katsumi, Y. Fong, T. G. Schmitt, E. Travison, T. G. Shafi, M. M. Libermann, T. A. Marcantonio, E. R. Alsop, D. C. Jones, R. N. Inouye, S. K. Dickerson, B. C. | Neurobiol Aging | 2024 |
Alzheimer’s disease |
| Dementia Development during Long-Term Follow-Up after Surgical Aortic Valve Replacement with a Biological Prosthesis in a Geriatric Population | Deblier, I. Dossche, K. Vanermen, A. Mistiaen, W. | J Cardiovasc Dev Dis | 2024 |
dementia |
| A Comparison of Efficacy between Low-dose Dexmedetomidine and Propofol for Prophylaxis of Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery: A Randomized Controlled Trial | Ekkapat, G. Kampitak, W. Theerasuwipakorn, N. Kittipongpattana, J. Engsusophon, P. Phannajit, J. Chokengarmwong, N. | Indian J Crit Care Med | 2024 |
Dexmedetomidine |
| Development and validation of a new drug-focused predictive risk score for postoperative delirium in orthopaedic and trauma surgery patients | Geßele, C. Saller, T. Smolka, V. Dimitriadis, K. Amann, U. Strobach, D. | BMC Geriatr | 2024 |
Humans |
| Preoperative cognitive performance and its association with postoperative complications in vascular surgery patients: A prospective study | Goodijk, D. Banning, L. B. D. Te Velde-Keyzer, C. A. van Munster, B. C. Bakker, S. J. L. van Leeuwen, B. L. Zeebregts, C. J. Pol, R. A. | Am J Surg | 2024 |
Cognition |
| Prognostic Nutritional Index and the Risk of Postoperative Complications After Spine Surgery: A Meta-Analysis | Guo, H. Yang, L. Liu, J. Yu, X. Chen, L. Huang, Y. | World Neurosurg | 2024 |
Humans |
| Risk stratification and predictive modeling of postoperative delirium in chronic subdural hematoma | Yang, X. Regmi, M. Wang, Y. Liu, W. Dai, Y. Liu, S. Lin, G. Yang, J. Ye, J. Yang, C. | Neurosurg Rev | 2024 |
Humans |
| Association between increased systemic immune-inflammation index and postoperative delirium in older intertrochanteric fracture patients | Yan, X. Huang, J. Chen, X. Lin, M. | J Orthop Surg Res | 2024 |
Humans |