Delirium Bibliography

Delirium Bibliography books graphicWhat is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title
Efficacy and safety of care bundles in the treatment of delirium in ICU patients: a meta-analysis and systemic review
Authors
Fang, D. Zeng, L. Kuang, F.
Year
2025
Journal
BMC Nurs
Abstract

OBJECTIVE: The aim is to explore the impact of care bundles on the efficacy and safety of delirium management in intensive care unit (ICU) patients compared to standard care through a meta-analysis and systematic review. METHOD: China National Knowledge Infrastructure (CNKI), Wanfang, PubMed, Web of Science (WOS), Embase, Cochrane, Chinese Biomedical Database (CBM), and VIP databases were searched from the database inception to December 1, 2024. The inclusion criteria based on the PICOS strategy include ICU patients (P), and randomized controlled trials (RCT) (S) comparing the treatment outcomes (such as incidence of delirium, duration of delirium, duration of mechanical ventilation, mortality rate, etc.) (O) between the care bundles (I) and standard care (C). Two investigators independently screened the literature, extracted the data, and assessed the quality of the included literature using the Cochrane Quality Assessment Tool. Meta-analysis was performed using STATA15.0 software. RESULTS: Eighteen studies were included with a total of 2,717patients involved. Most studies have a high/moderate risk of bias. The results of the meta-analysis demonstrated that care bundles was effective in decreasing the (1)incidence of delirium in ICU patients [risk ratio [RR] = 0.38, 95% confidence interval [CI] : 0.32, 0.45; P < 0.001], shortening the (2)duration of delirium(days) (weighted mean difference [WMD] = -1.60, 95% CI : -1.96, -1.23; P < 0.001), and (3)duration of mechanical ventilation in corresponding patients(days) (standardized mean difference [SMD] = -1.65, 95% CI : -2.40, -0.89; P < 0.001). However, there was no statistical difference in patient (4) mortality (RR = 0.78, 95% CI : 0.44, 1.40; P = 0.41). CONCLUSIONS: Care bundles have positive effects on delirium in ICU patients. However, results with significant heterogeneity should be interpreted with caution, and differences in bundles need to be taken into account. More multi-center, largesample randomized controlled studies are required to further explore the optimal components and combinations of care bundles.

PMID

PMID: 40170037

PMCID: PMC11963680

 

Keywords

Care bundles Delirium Icu Meta-analysis

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Total Records Found: 6753, showing 100 per page
TitleAuthorsJournalYearKeywords
Efficacy of perioperative dexmedetomidine on postoperative pain and neurocognitive functions in orthopaedic surgery: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials Zhang, X. Leng, Y. Yuan, X. Yang, Y. Zhou, C. Liu, H. Int J Surg 2025

orthopedic surgery, postoperative pain, postoperative cognitive dysfunction, dexmedetomidine, postoperative delirium

Elevated TDP-43 serum levels associated with postoperative delirium following major cardiac surgery Simon, C. Graves, O. K. Akeju, O. McKay, T. B. Brain Behav Immun Health 2025

Postoperative delirium, vulnerable patients, major cardiac surgery, prodromal dementia, TDP-43

Empowering Family Care Partners to Optimize Delirium Care for Persons Living With Dementia Shrestha, P. Fick, D. M. Susman, A. Akter, N. Res Gerontol Nurs 2025

Family care partners, caregiver priorities, delirium, dementia, delirium superimposed on dementia

Impact of Implantable Hearing Devices on Delirium Risk in Patients with Hearing Loss: A National Database Study Hambach, B. Patel, J. Nunes, K. Sina, E. M. Llerena, P. Knops, A. Chiffer, R. C. Hunter, J. B. Otol Neurotol 2025

Delirium, hearing loss, implantable hearing rehabilitation devices

Cerebrospinal fluid biomarkers of neuroinflammation and postoperative neurocognitive disorders in patients undergoing orthopedic surgery Feng, H. Liu, Y. Wang, X. Wang, C. Wang, T. Int J Surg 2025

Postoperative Neurocognitive Disorders, postoperative complications, recovery, cerebrospinal fluid, biomarkers, orthopedic surgery,

What are the experiences and support needs of district nurses caring for terminally ill people with delirium at home? A qualitative study Arnold, E. Lugton, J. Spiller, J. Finucane, A. BMC Palliat Care 2025

Humans *Qualitative Research *Delirium/nursing Scotland Female *Terminally Ill/psychology Male Middle Aged Adult Needs Assessment Home Care Services/standards Nurses/psychology Community Confusion Delirious Delirium Detection District nurses Home Management Palliative Prevention Terminal

ICU nurses' perceptions on family involvement in delirium care for postoperative cardiac surgery patients: A qualitative study Azimzadeh, D. Lapierre, A. Bouaouina, Z. Williamson, D. Mailhot, T. Arbour, C. Intensive Crit Care Nurs 2025

Cardiac surgery Delirium Family involvement Icu Nurse’s perception

Efficacy and safety of gastrodin in preventing postoperative delirium following cardiac surgery: a randomized placebo controlled clinical trial Bai, Y. X. Wu, H. L. Xie, W. L. Li, X. Han, J. J. Liu, J. Chen, S. Q. Yin, P. Dong, N. G. Wu, Q. P. Crit Care 2025

Humans *Benzyl Alcohols/therapeutic use/adverse effects Female Male *Glucosides/therapeutic use/adverse effects Middle Aged Double-Blind Method Aged *Delirium/prevention & control/etiology *Postoperative Complications/prevention & control Cardiac Surgical Procedures/adverse effects Adult Cardiac surgery Delirium Gastrodin

Neuroimaging biomarkers on routine Computed Tomography (CT) after acute stroke and their association with post-stroke delirium: A cohort study Barugh, A. Farrall, A. Ferguson, K. Shenkin, S. MacLullich, A. Mead, G. J Stroke Cerebrovasc Dis 2025

Brain imaging Cistern ambiens Computed tomography Delirium Stroke

Preoperative prediction models for postoperative delirium in cardiac surgery patients - a scoping review Blakoe, M. Olsen, D. B. Noergaard, M. W. Contemp Nurse 2025

cardiac surgery delirium postoperative delirium prediction prognostic

A Deep-Learning-Based Approach for Delirium Monitoring in ICU Patients Using Thermograms Blase, D. Chayeb, O. Chan, P. Y. Leonhardt, S. Lueken, M. Annu Int Conf IEEE Eng Med Biol Soc 2024

Humans *Delirium/diagnosis *Intensive Care Units *Deep Learning *Thermography/methods Monitoring, Physiologic/methods Male Female Aged Neural Networks, Computer Middle Aged

Exploring Post-Anaesthesia Care Unit Nurses' Experiences Post Participation in a Delirium Care for Older People Education Intervention: A Qualitative Study Bowden, A. Wilson, V. Bresolin, J. Nealon, J. Traynor, V. Int J Older People Nurs 2025

Humans *Qualitative Research *Delirium/nursing Aged Female Male *Clinical Competence Postanesthesia Nursing Nursing Staff, Hospital/education/psychology Geriatric Nursing/education Postoperative Complications/nursing Middle Aged Adult delirium nursing education nursing practice older people professional development simulation‐based‐education

Hemoglobin to red cell distribution width ratio predicts postoperative delirium in older patients undergoing hip fracture surgery: A retrospective cohort study Cao, X. Zhang, H. Li, Y. Liu, M. He, J. Li, J. Geriatr Gerontol Int 2025

Humans *Hip Fractures/surgery Male Female Retrospective Studies Aged Aged, 80 and over *Hemoglobins/analysis *Delirium/blood/etiology/diagnosis *Postoperative Complications/blood/diagnosis Predictive Value of Tests *Erythrocyte Indices ROC Curve hemoglobin to red blood cell distribution width ratio hip fracture surgery older patients postoperative delirium risk factor

Mapping the Nursing Literature on Postoperative Delirium: A Bibliometric Analysis Cetinkaya, M. M. Taylan, S. Eti Aslan, F. J Perianesth Nurs 2025

bibliometric analysis delirium nursing surgery

Mapping the Nursing Literature on Postoperative Delirium: A Bibliometric Analysis Cetinkaya, M. M. Taylan, S. Eti Aslan, F. J Perianesth Nurs 2025

bibliometric analysis delirium nursing surgery

Haloperidol in treating delirium, reducing mortality, and preventing delirium occurrence: Bayesian and frequentist meta-analyses Cheng, S. L. Hsu, T. W. Kao, Y. C. Yu, C. L. Thompson, T. Carvalho, A. F. Stubbs, B. Tseng, P. T. Hsu, C. W. Yang, F. C. Tu, Y. K. Liang, C. S. Crit Care 2025

*Haloperidol/therapeutic use/adverse effects Humans *Delirium/drug therapy/prevention & control *Bayes Theorem Antipsychotic Agents/therapeutic use/adverse effects Intensive Care Units/statistics & numerical data Mortality/trends Bayesian meta-analysis Delirium Haloperidol Intensive care unit patients Mortality

Delirium management in 2024: A status check and evolution in clinical practice since 2016 Coolens, O. Kaltwasser, A. Melms, T. Monke, S. Nydahl, P. Pelz, S. von Haken, R. Hasemann, W. Intensive Crit Care Nurs 2025

Best practice Critical care Culture Delirium Delirium management Encephalopathy

Machine Learning-Based Prediction of Delirium and Risk Factor Identification in Intensive Care Unit Patients With Burns: Retrospective Observational Study Esumi, R. Funao, H. Kawamoto, E. Sakamoto, R. Ito-Masui, A. Okuno, F. Shinkai, T. Hane, A. Ikejiri, K. Akama, Y. Gaowa, A. Park, E. J. Momosaki, R. Kaku, R. Shimaoka, M. JMIR Form Res 2025

Humans *Delirium/diagnosis/epidemiology *Machine Learning Male Female Middle Aged Retrospective Studies *Intensive Care Units *Burns/complications Risk Factors Adult Aged ROC Curve Risk Assessment/methods Ai artificial intelligence burns delirium intensive care unit machine learning prediction model

The perceptions of European geriatricians on the co-occurrence and links between dementia, delirium and frailty Faherty, M. Curtin, C. Bellelli, G. Brunetti, E. Bo, M. Morandi, A. Cherubini, A. Fedecostante, M. Ferrara, M. C. Coin, A. Shenkin, S. D. Soysal, P. Timmons, S. Eur Geriatr Med 2025

Attitudes Delirium Dementia Frailty Prevalence Risk factors

Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery Fallon, J. M. Hashemaghaie, M. Peterson, C. E. Tran, D. Wu, S. R. Valdes, J. M. Pedicini, N. M. Adams, M. E. Soltis, M. Mansour, W. Wright, M. C. Raghunathan, K. Treggiari, M. M. Sasannejad, C. Devinney, M. J. BMJ Open 2025

Humans Double-Blind Method *Azepines/therapeutic use Aged *Triazoles/therapeutic use *Delirium/prevention & control *Postoperative Complications/prevention & control Randomized Controlled Trials as Topic Orexin Receptor Antagonists/therapeutic use/administration & dosage Male Sleep Aids, Pharmaceutical/therapeutic use/administration & dosage Female Sleep/drug effects Clinical Trial Delirium Sleep medicine

Efficacy and safety of care bundles in the treatment of delirium in ICU patients: a meta-analysis and systemic review Fang, D. Zeng, L. Kuang, F. BMC Nurs 2025

Care bundles Delirium Icu Meta-analysis

Delirium prevention in hospices: Opportunities and limitations - A focused ethnography Featherstone, I. Johnson, M. J. Sheldon, T. Kelley, R. Hawkins, R. Bravington, A. Callin, S. Dixon, R. Obita, G. Siddiqi, N. Palliat Med 2025

Humans *Delirium/prevention & control *Anthropology, Cultural Male Female Hospices Aged Middle Aged Hospice Care United Kingdom Adult Aged, 80 and over Attitude of Health Personnel Qualitative Research Delirium palliative care

Amplitude coupling is altered in delirium of various etiologies: Results from a retrospective multi-center case-control EEG study Fleischmann, R. Mengel, A. Stam, C. J. Leroy, S. Schneider, P. Slooter, A. J. C. Ehler, J. van Dellen, E. Clin Neurophysiol 2025

Amplitude-amplitude coupling Connectivity Delirium Electroencephalography Postoperative Stroke

Effect size estimates of risk factors for post-intensive care syndrome: A systematic review and meta-analysis Gao, S. Liang, X. Pan, Z. Zhang, X. Zhang, L. Intensive Crit Care Nurs 2025

Humans Risk Factors *Intensive Care Units/organization & administration Female Male Critical Care/methods/psychology Critical Illness Intensive care units Meta-analysis Post intensive care syndrome Survivors

Health-care staff perspectives in optimising delirium prevention using data-driven interventions Gokhale, S. Garth, B. Webb-St Mart, M. Taylor, D. Zeps, N. Enticott, J. Teede, H. Reeder, S. Australas J Ageing 2025

Humans *Delirium/prevention & control/diagnosis *Qualitative Research *Attitude of Health Personnel Interviews as Topic Risk Assessment Male Female Health Knowledge, Attitudes, Practice Health Personnel/psychology Risk Factors data‐driven optimisation delirium prevention health services research learning health system pre‐implementation factors

Frailty screening of older patients in emergency departments in Norway Goll, J. B. Saga, E. Johnsen, B. Hoff, O. M. Martinaityte, I. Halvorsen, D. S. Søvde Å, K. Gundersen, M. D. Wang-Hansen, M. Tidsskr Nor Laegeforen 2025

Humans Norway/epidemiology Aged Female Aged, 80 and over Male *Emergency Service, Hospital/statistics & numerical data *Frail Elderly/statistics & numerical data *Frailty/diagnosis/epidemiology *Geriatric Assessment/methods Delirium/diagnosis/epidemiology Mass Screening

Delirium following mechanical thrombectomy for ischemic stroke - individuals at risk, imaging biomarkers and prognosis Hahn, M. Brockstedt, L. Gröschel, S. Geschke, K. Grauhan, N. F. Brockmann, M. A. Othman, A. E. Gröschel, K. Uphaus, T. Front Aging Neurosci 2025

atrophy complications delirium endovascular stroke therapy mechanical thrombectomy prognosis stroke

Remifentanil use in critically Ill patients requiring mechanical ventilation is associated with increased delirium-free days: a retrospective study Haruna, J. Sasaki, A. Kazuma, S. Int J Emerg Med 2025

Critical illness Delirium Remifentanil

Outcomes of Older Adults With Delirium Discharged From the Emergency Department Howick, A. S. Thao, P. Carpenter, K. P. Boie, M. A. Maia, I. W. A. Mullan, A. F. Bower, S. M. Palmer, A. K. Carpenter, C. R. Liu, S. W. Jeffery, M. M. Bellolio, F. Ann Emerg Med 2025

Dementia Frailty Geriatrics, delirium Mortality Older adult

Association between intraoperative electroencephalograph complexity index and postoperative delirium in elderly patients undergoing orthopedic surgery: a prospective cohort study Hu, X. Y. Dai, Y. C. Zhu, L. Y. Yang, J. J. Sun, J. Ji, M. H. J Anesth 2025

Complexity Eeg Electroencephalogram Postoperative delirium

Hypnotic drug use and intraoperative fluid balance associated with postoperative delirium following pancreatic surgery: A retrospective, observational, single-center study Huang, Z. H. Zhang, J. Xu, X. Y. Wang, Y. Lu, X. J. Luo, Y. PLoS One 2025

Humans Male Female Retrospective Studies Aged Middle Aged *Delirium/etiology *Postoperative Complications/etiology Risk Factors *Hypnotics and Sedatives/adverse effects Water-Electrolyte Balance Pancreas/surgery

Natriuretic Peptides as a Predictor for Delirium After Cardiac Surgery: A Prospective Observational Study Huisinga, C. Struck, E. Mihatsch, L. Heyn, J. Hagl, C. Zwissler, B. von Dossow, V. Saller, T. J Clin Med 2025

biomarker cardiac surgery delirium natriuretic peptides neurocognitive disorders quality of life short form 36 questionnaire

Albumin/fibrinogen ratio (AFR): a significant predictor of postoperative delirium in older patients undergoing non-neurosurgical and non-cardiac surgery Huo, J. Song, Y. Lu, J. Dou, G. Chen, H. Mi, W. Yu, Y. Liu, Y. BMC Geriatr 2025

Humans Female Aged Male Retrospective Studies *Fibrinogen/analysis/metabolism *Postoperative Complications/diagnosis/epidemiology/blood *Delirium/diagnosis/blood/epidemiology Aged, 80 and over Prognosis Serum Albumin/metabolism Surgical Procedures, Operative/adverse effects Biomarkers/blood Predictive Value of Tests Risk Factors Aged patients Albumin to Fibrinogen Biomarker Postoperative delirium

Effect of Ascorbic Acid on the Incidence of Postoperative Delirium Among Elderly Patients Undergoing Cardiovascular Surgery: A Pilot Study Iizuka, Y. Fukano, K. Oki, S. Sawada, I. Miyazawa, K. Ono, S. Yoshinaga, K. Sanui, M. Yamaguchi, A. J Clin Med Res 2025

Ascorbic acid Cardiac surgery Postoperative delirium

Preoperative Cognitive Optimization and Postoperative Cognitive Outcomes: A Narrative Review Ishizawa, Y. Clin Interv Aging 2025

Humans *Delirium/prevention & control Aged Cognitive Dysfunction/prevention & control Postoperative Cognitive Complications/prevention & control Cognition Preoperative Care/methods Postoperative Complications/prevention & control cognitive frailty cognitive optimization perioperative neurocognitive disorder postoperative cognitive impairment postoperative delirium

Delirium risk profiles in a population-based study of United States older adults undergoing common noncardiac surgeries Joo, H. Avelino-Silva, T. J. Diaz-Ramirez, L. G. Lee, S. J. Whitlock, E. L. J Am Geriatr Soc 2025

Humans Male Aged Female United States/epidemiology Risk Factors *Delirium/epidemiology Aged, 80 and over *Postoperative Complications/epidemiology Surgical Procedures, Operative/adverse effects Medicare/statistics & numerical data Risk Assessment/methods and noncardiac surgeries older adults postoperative delirium risk profile

Risk factors and outcomes of hyperactive delirium in older medical inpatients admitted to non-intensive care unit: a prospective cohort study Kaewpongsa, P. Jayanama, K. Ruangritchankul, S. BMC Psychiatry 2025

Humans *Delirium/epidemiology/diagnosis Male Female Risk Factors Aged Prospective Studies Aged, 80 and over *Inpatients/statistics & numerical data Middle Aged Hospitalization *Psychomotor Agitation/epidemiology Hyperactive delirium Mortality Older adults Risk factor

A multicenter prospective study on the prevalence of Post Stroke Delirium and associated risk factors in Addis Ababa, Ethiopia Ketema, B. Mengistu, G. Melka, D. Zenebe, Y. Zebenigus, M. Leul, F. BMC Neurol 2025

Humans *Delirium/epidemiology/etiology/diagnosis Ethiopia/epidemiology Female Male Risk Factors Prevalence Middle Aged Prospective Studies Aged *Stroke/epidemiology/complications Adult Aged, 80 and over Delirium Stroke Tikur Anbessa Specialized Hospital Yehulshet Specialty Center Yekatit 12 Hospital and Medical College

Clinical Profile and Outcome of Delirium in Patients in The Semi-Closed Intensive Care Unit Keyal, N. K. Sherpa, A. D. Kumar, R. Ansari, I. J Nepal Health Res Counc 2025

Humans *Delirium/epidemiology Male *Intensive Care Units Female Prospective Studies Middle Aged Nepal/epidemiology Adult *apache Risk Factors Aged Length of Stay/statistics & numerical data Respiration, Artificial Delirium intensive care units mortality.

SURGE-ahead postoperative delirium prediction: external validation and open-source library Kocar, T. D. Wolf, P. Leinert, C. Brefka, S. Fotteler, M. L. Uihlein, A. Wezel, F. Wehling, M. Rahbari, N. Kestler, H. Gebhard, F. Dallmeier, D. Denkinger, M. Eur Geriatr Med 2025

Artificial intelligence Delirium prediction Explainable AI Machine learning Postoperative delirium

The Impact of Non-Pharmacological Sleep Interventions on Delirium Prevention and Sleep Improvement in Postoperative ICU Patients: A Systematic Review and Network Meta-Analysis Li, J. Fan, Y. Luo, R. Yin, N. Wang, Y. Jing, J. Zhang, J. Intensive Crit Care Nurs 2025

Humans *Delirium/prevention & control *Intensive Care Units/organization & administration *Network Meta-Analysis as Topic Delirium Intensive Care Unit Network meta-analysis Non-pharmacological interventions Sleep

Developing a nomogram for postoperative delirium in elderly patients with hip fractures Li, L. Sheng, W. W. Song, L. J. Cheng, S. Cui, E. G. Zhang, Y. B. Yu, X. Z. Liu, Y. L. World J Psychiatry 2025

Hip fracture Nomogram Postoperative delirium Retrospective study Risk factor

The effect of perioperative cognitive training on postoperative delirium in older patients undergoing total hip and knee arthroplasty: a prospective randomised trial Lia, T. Yua, C. Lv, F. Feng, Z. Hou, Y. Ren, L. Li, P. Age Ageing 2025

Humans Aged *Arthroplasty, Replacement, Knee/adverse effects *Arthroplasty, Replacement, Hip/adverse effects Male Female Prospective Studies Middle Aged Delirium/prevention & control/epidemiology/diagnosis/psychology/etiology Incidence Cognitive Behavioral Therapy/methods Postoperative Complications/prevention & control/epidemiology/etiology Cognition Treatment Outcome Perioperative Care/methods Cognitive Training general anaesthesia older people postoperative delirium total hip and knee arthroplasty

Delirium is a Potential Predictor of Unfavorable Long-term Functional Outcomes in Patients with Acute Ischemic Stroke: A Prospective Observational Study Lin, C. Zhang, H. Xiao, F. Tu, Y. Lin, Y. Zhan, L. Lin, Y. Li, Y. Xie, C. Chen, Y. J Inflamm Res 2025

Ais Psd acute ischemic stroke biomarkers coagulation dysfunction delirium mRS modified rankin scale neuroinflammation post-stroke delirium

Evidence from a Mendelian randomization study: Delirium's noncausal role in dementia onset Lu, Z. Wang, X. Mao, T. Liu, L. Zhang, J. Neuroscience 2025

Delirium Dementia Mendelian randomization Older people

Evaluation of postoperative delirium in cardiac surgery patients with the SDACS screening tool: a multicenter-multiphase study Mahmoudi, H. Chalkias, A. Moradi, A. Moradian, S. T. Amouzegar, S. M. R. Vahedian-Azimi, A. Perioper Med (Lond) 2025

Cardiac surgery Critical care Delirium Early prediction Intensive care Screening tool

Nurse-perceived barriers and facilitators influencing optimal delirium care in acute care patients: Findings from the INVOLVE_RN study on barriers and facilitators Mailhot, T. Crump, L. Clausen, C. Valentine-Joannette, T. Bouaouina, Z. Leblanc, M. E. Bitzas, V. Khetir, I. Lavoie, P. Geriatr Nurs 2025

Acute care Barriers Delirium Facilitators Guidelines Nursing practice

Delirium in the Acute Care Setting From the Families Perspective: A Scoping Review McLean, A. Ewens, B. Towell-Barnard, A. J Adv Nurs 2025

acute care delirium families experience family centred care nursing

Establishment and validation of a nomogram of postoperative delirium in patients undergoing cardiac surgery: a retrospective study of MIMIC-IV Mei, H. Liao, G. Ye, B. Wen, M. Li, J. BMC Cardiovasc Disord 2025

Humans *Nomograms Male Female Retrospective Studies *Cardiac Surgical Procedures/adverse effects Aged Middle Aged Risk Assessment Risk Factors *Predictive Value of Tests Reproducibility of Results *Decision Support Techniques Databases, Factual Delirium/diagnosis/etiology/epidemiology Treatment Outcome Cardiac surgery Icu Mimic-iv Nomogram Postoperative delirium

Cytokines and inflammatory biomarkers and their association with post-operative delirium: a meta-analysis and systematic review Mosharaf, M. P. Alam, K. Gow, J. Mahumud, R. A. Sci Rep 2025

Humans *Biomarkers/blood *Cytokines/blood *Delirium/blood/etiology/diagnosis *Postoperative Complications/blood/etiology Inflammation/blood/metabolism C-reactive proteins Cytokines and inflammatory proteins Interleukins Post-operative delirium Systematic review and meta-analysis

Preoperative brain volume loss is associated with postoperative delirium in advanced heart failure patients supported by left ventricular assist device Murrieta-Álvarez, I. Scioscia, J. P. Benítez-Salazar, J. M. Uwaeze, J. Xu, Z. Zheng, G. Li, S. Braverman, V. Walther, C. P. Shafii, A. E. Hochman-Mendez, C. Rosengart, T. K. Liao, K. K. Mondal, N. K. Sci Rep 2025

Humans *Heart-Assist Devices/adverse effects *Heart Failure *Delirium/etiology Male Female Middle Aged *Brain/diagnostic imaging/pathology Aged *Postoperative Complications/etiology Tomography, X-Ray Computed Atrophy Preoperative Period Retrospective Studies Brain Delirium Heart failure Mechanical circulatory support Neuroimaging Neurological dysfunction

Assessing delirium knowledge among health care professionals: findings from a scoping review Muzzana, C. Mansutti, I. Palese, A. Ausserhofer, D. BMC Nurs 2025

Delirium Health personnel Healthcare professionals Instruments Knowledge Scoping review

Delirium assessment, management and barriers to effective care across Scotland: A secondary analysis of survey data from World Delirium Awareness Day 2023 Naeem, F. Penfold, R. S. Soiza, R. L. Von Haken, R. Lindroth, H. Liu, K. Nydhal, P. Quinn, T. J. J R Coll Physicians Edinb 2025

*Delirium/therapy/diagnosis Humans Scotland Guideline Adherence/statistics & numerical data Surveys and Questionnaires Aged Prevalence Practice Guidelines as Topic Male Scotland/epidemiology delirium geriatrics hospitals

Screening of toxic-metabolic encephalopathy with and without epileptic seizure with density spectral array Ohno, N. Neshige, S. Abe, T. Nonaka, M. Yamada, H. Takebayashi, Y. Ishibashi, H. Shishido, T. Aoki, S. Yamazaki, Y. Ueno, H. Iida, K. Maruyama, H. J Neurol Sci 2025

Loss of consciousness Neurotoxicity Nonconvulsive seizure Seizure Status epilepticus

Development and Validation of a Machine Learning Model for Early Prediction of Delirium in Intensive Care Units Using Continuous Physiological Data: Retrospective Study Park, C. Han, C. Jang, S. K. Kim, H. Kim, S. Kang, B. H. Jung, K. Yoon, D. J Med Internet Res 2025

Humans *Delirium/diagnosis *Machine Learning *Intensive Care Units Male Retrospective Studies Female Middle Aged Aged Reproducibility of Results Adult delirium early prediction intensive care unit machine learning prediction model

Persistence of Delirium in Postacute Care at Skilled Nursing Facilities Park, C. M. Shi, S. Jones, R. N. Metzger, E. D. Vasunilashorn, S. M. Fong, T. Kim, D. H. Inouye, S. K. JAMA Netw Open 2025

Humans *Skilled Nursing Facilities/statistics & numerical data *Delirium/epidemiology/diagnosis Female Male Cross-Sectional Studies *Subacute Care/statistics & numerical data Aged United States/epidemiology Aged, 80 and over *Medicare/statistics & numerical data

Delirium on presentation with a hip fracture is associated with adverse outcomes : a multicentre observational study of 18,040 patients using national clinical registry data Penfold, R. S. Farrow, L. Hall, A. J. Clement, N. D. Ward, K. Donaldson, L. Johansen, A. Duckworth, A. D. Anand, A. Hall, D. E. Guthrie, B. MacLullich, A. M. J. Bone Joint J 2025

Humans *Delirium/epidemiology/etiology *Hip Fractures/complications/surgery Female Male *Registries Aged, 80 and over Aged Scotland/epidemiology Middle Aged Prevalence Hospital Mortality Risk Factors

Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis Qiu, L. Q. Song, J. L. Zhang, L. C. Fan, B. Li, Q. Lu, B. Chen, G. Y. Front Aging Neurosci 2025

hypercholesterolemia hyperlipidemias hypertriglyceridemia meta-analysis postoperative delirium

Postoperative Delirium after Reverse Total Shoulder Arthroplasty: Interscalene Block Versus General Anesthesia Rhee, S. M. Kim, S. Y. Kim, C. H. Radhakrishna, K. Dwivedi, D. D. Kim, S. Y. Ham, H. J. Rhee, Y. G. Clin Orthop Surg 2025

Humans Aged *Anesthesia, General *Arthroplasty, Replacement, Shoulder/adverse effects Aged, 80 and over Male Female Prospective Studies Case-Control Studies *Rotator Cuff Injuries/surgery Delirium/etiology Postoperative Complications/etiology Nerve Block Interscalene nerve block Postoperative delirium Total shoulder arthroplasty

Prevalence and Risk Factors for Delirium on Arrival at the Emergency Room by Ambulance Sakuramoto, H. Onuma, J. Uno, S. Ikeda, M. Okamoto, S. Nakano, H. Hasimoto, H. Ouchi, A. Cureus 2025

ambulance delirium emergency room older adults psychiatry

Validation and Translation of the 3D-CAM to Turkish in Surgical Intensive Care Patients Sarı, S. Dilsiz, P. Eker, T. Şahin, S. Şahin, M. D. Doğan, B. Özçiftçi, P. Özcan, H. Dostbil, A. İyisoy, M. S. Turan, O. Taşkın, F. Kyenshilik, D. Kazaylek, M. İnce, İ Turan, A. Turk J Anaesthesiol Reanim 2025

3d-cam Delirium Intensive Care Turkish Version Validation

Evaluating oxygen reserve index-guided oxygenation for the prevention of postoperative delirium in elderly patients: a randomized controlled trial Sarıtaş, P. U. Sarıtaş, A. Poyraz, MÇ Croat Med J 2025

Humans Aged Female Male *Oximetry *Postoperative Complications/prevention & control Delirium/prevention & control/etiology Aged, 80 and over Oxygen/blood Incidence Oxygen Inhalation Therapy/methods Oxygen Saturation

Delirium prevalence and management in general wards, emergency departments, rehabilitation centres and nursing homes in Germany, Austria and Switzerland (DACH countries): A secondary analysis of a worldwide point prevalence study Schimböck, F. Krüger, L. Hoffmann, M. Jeitziner, M. M. Lindroth, H. Liu, K. Nydahl, P. Von Haken, R. Thomas Exl, M. Fischbacher, S. Int J Nurs Stud Adv 2025

Delirium Encephalopathy Nurses Prevalence Protocol

Lipid Dysregulation and Delirium in Older Adults: A Review of the Current Evidence and Future Directions Shaw, A. Teng, R. Fasina, T. Gonzales, A. S. Wong, A. Schweitzer, D. Akefe, I. Brain Res Bull 2025

Delirium Endocannabinoids Fatty Acids Healthy Ageing Lipid Dysregulation Neuropsychiatric Disorders Phospholipids Sphingolipids

Risk factors for transitions and outcomes of subsyndromal delirium in the ICU: Post-hoc analysis of a prospective multicenter cohort study Smit, L. Wiegers, E. J. A. Trogrlic, Z. Gommers, D. Ista, E. van der Jagt, M. J Crit Care 2025

Critical care Delirium Diagnosis Intensive care unit Outcomes Risk factors

Protein Alterations in Patients with Delirium after Cardiac Surgery: An Exploratory Case-Control Substudy of the VISION Cardiac Surgery Biobank Spence, J. Devereaux, P. J. Bashir, S. Brady, K. Sun, T. Chan, M. T. V. Wang, C. Y. Lamy, A. Whitlock, R. P. McIntyre, W. F. Belley-Côté, E. Paré, G. Chong, M. Anesthesiology 2025

Humans Male Female *Cardiac Surgical Procedures/adverse effects Case-Control Studies *Delirium/blood/etiology/diagnosis Aged *Biomarkers/blood *Postoperative Complications/blood/diagnosis/etiology *Biological Specimen Banks Middle Aged Blood Proteins/analysis Cohort Studies

Association Between Oxidative Stress Markers and Postoperative Delirium in Elderly Patients Undergoing Oncologic Surgery Stanculescu, A. D. Dragoescu, P. O. Andrei, M. Chiutu, L. Dragoescu, N. A. Curr Health Sci J 2024

Postoperative delirium glutathione peroxidase malondialdehyde superoxide dismutase

Long-term mortality impact of postoperative hyperactive delirium in older hip fracture surgery patients Sun, M. Chen, W. M. Wu, S. Y. Zhang, J. BMC Geriatr 2025

Humans Female *Hip Fractures/surgery/mortality Male Aged Aged, 80 and over *Postoperative Complications/mortality/epidemiology/diagnosis *Delirium/mortality/epidemiology/diagnosis Taiwan/epidemiology Risk Factors Cohort Studies Propensity Score Hip fracture Mortality Older Postoperative hyperactive delirium Propensity score matching

Person-centered care-based digital transformation education program for elderly dementia patients with delirium: a comparison of the effect on nurses and doctors Suzuki, M. Ito, T. Inagaki, K. Mimuro, S. Yamakawa, M. Takiue, K. Sawaki, K. Komatsu, Y. Uchiyama, M. Kawashima, C. Yamazaki, K. Satoh, M. Isogai, S. Nihon Ronen Igakkai Zasshi 2025

Humans *Dementia/nursing/therapy *Patient-Centered Care *Delirium/therapy/nursing Aged *Nurses Female *Physicians Male Surveys and Questionnaires Delirium Dementia Digital transformation (DX) program Person-centered care

Risk factors for postoperative delirium in patients undergoing orthopedic procedures: a systematic review and meta-analysis Suzuki, R. Nakanishi, A. Masuya, M. Fukuroku, K. Taneda, Y. Matsuura, Y. PLoS One 2025

Humans Risk Factors *Orthopedic Procedures/adverse effects *Delirium/etiology/epidemiology *Postoperative Complications/etiology/epidemiology Length of Stay

Airway Safety During Mechanical Ventilation: Survey of ICU Clinicians Practices and Perceptions Tanios, M. A. Stocking, J. C. Charchaflieh, J. G. Miller, A. G. Patel, J. V. Vilella, A. L. Nguyen, H. M. Epstein, S. K. Beltran, A. Devlin, J. W. Crit Care Explor 2025

Humans *Intensive Care Units *Respiration, Artificial/adverse effects Surveys and Questionnaires Airway Management/methods/adverse effects Patient Safety Airway Extubation/adverse effects Attitude of Health Personnel Practice Patterns, Physicians’/statistics & numerical data

A Cross-Sectional Study of Online Survey Respondents' Knowledge and Attitudes Toward Delirium Townshend, R. Vasilevskis, E. E. Hollnagel, F. Golden, B. P. J Gen Intern Med 2025

caregiver education delirium patient education

Impact of Ketamine and Propofol on Cognitive Function in Elderly Patients: A Systematic Review Van de Vel, G. Mun, S. Zia, S. U. D. Chalasani, R. Shukla, P. S. Malasevskaia, I. Cureus 2025

delirium elderly ketamine postoperative cognitive dysfunction propofol

Preoperative quantitative quadriceps muscle ultrasound to predict POD for gastrointestinal surgery in older patients Wang, C. Song, X. Cao, L. Guo, F. Gao, J. BMC Gastroenterol 2025

Humans Male Female Aged *Ultrasonography/methods *Quadriceps Muscle/diagnostic imaging *Postoperative Complications/etiology/diagnostic imaging *Digestive System Surgical Procedures/adverse effects/methods Risk Factors Prospective Studies *Delirium/etiology Preoperative Period Aged, 80 and over Nomograms ROC Curve China Logistic Models Predictive Value of Tests Gastrointestinal surgery Nomogram Postoperative delirium Quantitative muscle ultrasound

Medical staff's knowledge of delirium by occupation and the effectiveness of an on-demand e-learning Yamagata, H. Kobayashi, R. Hirose, K. Seki, T. Takihara, T. PCN Rep 2025

delirium e‐learning liaison psychiatry staff education team‐based medicine

The relationship between preoperative serum indirect bilirubin and postoperative delirium in geriatric patients undergoing joint replacement Yu, R. Yang, M. Chen, J. Zhang, F. PLoS One 2025

Humans Male Female Aged *Bilirubin/blood Aged, 80 and over *Arthroplasty, Replacement, Knee/adverse effects *Delirium/blood/etiology/diagnosis *Postoperative Complications/blood/etiology Arthroplasty, Replacement, Hip/adverse effects Risk Factors Preoperative Period

Exploring the causal relationship between delirium and sarcopenia using bidirectional two-sample Mendelian randomization study Zhou, R. Fu, Y. Wan, P. Cheng, B. Prog Neuropsychopharmacol Biol Psychiatry 2025

Appendicular lean mass Delirium Gwas Low hand-grip strength Mendelian randomization

Preventive effects of early mobilisation on delirium incidence in critically ill patients: systematic review and meta-analysis Zhou, L. Xie, F. Zeng, Y. Xia, X. Wang, R. Cai, Y. Lei, Y. Xu, F. Li, X. Chen, B. Med Klin Intensivmed Notfmed 2025

Delirium Early mobilisation Intervention Non-drug intervention Rehabilitation

Comparison of the effects of perioperative fentanyl and morphine use on the short-term prognosis of patients with cardiac surgery in the ICU Zhong, J. Sui, R. Zi, J. Wang, A. Front Pharmacol 2024

cardiac surgery delirium fentanyl in-hospital mortality morphine

Comparison of the effects of perioperative fentanyl and morphine use on the short-term prognosis of patients with cardiac surgery in the ICU Zhong, J. Sui, R. Zi, J. Wang, A. Front Pharmacol 2024

cardiac surgery delirium fentanyl in-hospital mortality morphine

Comparison of the effects of perioperative fentanyl and morphine use on the short-term prognosis of patients with cardiac surgery in the ICU Zhong, J. Sui, R. Zi, J. Wang, A. Front Pharmacol 2024

cardiac surgery delirium fentanyl in-hospital mortality morphine

Development and usability evaluation of a nurse-led clinical decision support system (AI-AntiDelirium) for management of intensive care unit delirium: A mixed methods study Zhang, S. Ding, S. Cui, W. Li, X. Wei, J. Wu, Y. Appl Nurs Res 2025

Humans *Delirium/nursing Cross-Sectional Studies *Decision Support Systems, Clinical Female Male Adult *Intensive Care Units Middle Aged Critical Care Nursing/methods/standards Nursing Staff, Hospital/psychology Clinical decision supporting system Delirium Intensive care unit Nurses Usability testing

Serum-derived exosomal microRNAs as biomarkers for postoperative delirium Xu, M. Chen, Y. Lin, Y. Wang, D. Zheng, X. Front Neurosci 2025

biomarkers cognitive decline microRNA postoperative delirium serum exosomes

Enhanced machine learning predictive modeling for delirium in elderly ICU patients with COPD and respiratory failure: A retrospective study based on MIMIC-IV Wu, Z. B. Jiang, Y. L. Li, S. S. Li, A. PLoS One 2025

Humans *Delirium/diagnosis *Machine Learning Aged Female Male *Pulmonary Disease, Chronic Obstructive/complications *Intensive Care Units *Respiratory Insufficiency Retrospective Studies Aged, 80 and over Risk Factors Prognosis

Unraveling the impact of frailty on postoperative delirium in elderly surgical patients: a systematic review and meta-analysis Wu, H. Yan, S. Cao, H. Feng, C. Zhang, H. BMC Anesthesiol 2025

Humans *Frailty Aged Postoperative Complications/epidemiology Frail Elderly Delirium/epidemiology Emergence Delirium/epidemiology Delirium Elderly Frailty Meta-analysis

Evaluating the relationship between inflammatory markers and preoperative delirium in elderly hip fracture patients: A retrospective observational study Wang, S. Yu, S. Li, C. Li, T. Li, H. Zhang, B. Han, L. Zhan, H. Zhang, Y. Medicine (Baltimore) 2025

Humans *Hip Fractures/surgery/blood/complications *Delirium/blood/etiology/diagnosis/epidemiology Male Retrospective Studies Female Aged Aged, 80 and over *Biomarkers/blood Inflammation/blood Preoperative Period Risk Factors Age Factors Neutrophils/metabolism Comorbidity

Predictors of postoperative delirium in patients undergoing radical prostatectomy: a prospective study Wang, H. Chen, J. Chen, J. Chen, Y. Qin, Y. Liu, T. Pan, S. Xie, Y. Support Care Cancer 2025

Humans Male Prospective Studies *Prostatectomy/adverse effects/methods Aged Risk Factors *Postoperative Complications/epidemiology/etiology *Delirium/etiology/epidemiology Middle Aged *Nomograms Prostatic Neoplasms/surgery Logistic Models Elderly patients Nomogram Postoperative delirium Prostate cancer

Development of a Disease Model for Predicting Postoperative Delirium Using Combined Blood Biomarkers Wan, H. Tian, H. Wu, C. Zhao, Y. Zhang, D. Zheng, Y. Li, Y. Duan, X. Ann Clin Transl Neurol 2025

blood biomarkers cognitive decline hyperlipidemia machine learning postoperative delirium

Consequences of the Crisis in Social Care for Older Hospital Inpatients with Frailty Ahmed, R. Cloonan, J. May, E. Chambers, H. Madden, R. Doyle, J. Briggs, R. Ir Med J 2025

Humans Female Male Aged Aged, 80 and over *Frail Elderly *Quality of Life Patient Discharge Inpatients/psychology Home Care Services Depression/epidemiology Frailty Accidental Falls/statistics & numerical data/prevention & control Delirium/therapy/epidemiology Loneliness/psychology Hospitalization/statistics & numerical data

Predicting Postoperative Delirium Using Intraoperative Neuromonitoring in Patients Undergoing Craniotomy for Aneurysm Clipping Surgery Al-Qudah, A. M. Alkalbani, L. Tallapaneni, P. S. Vinuthna, D. V. Suresh, V. Anetakis, K. M. Crammond, D. Balzer, J. Shandal, V. Visweswaran, S. Subramaniam, K. Sadhasivam, S. Thirumala, P. Eur Neurol 2025

Postoperative delirium, Intracranial surgery, IONM, SSEPs, EEG, CBF

Intraoperative neuromonitoring as an independent predictor for postoperative delirium in ICU following aneurysm clipping Al-Qudah, A. M. Tallapaneni, P. S. Crammond, D. J. Balzer, J. Anetakis, K. M. Shandal, V. Biaesch, J. Ghannam, M. Nadkarni, N. Gross, B. A. Lang, M. Subramanium, K. Sadhasivam, S. Thirumala, P. D. eNeurologicalSci 2025

Aneurysm Clipping Craniotomy Delirium Icu Intraoperative neurophysiologic monitoring SSEP EEG

Daylighting and Patients' Access to View Assessment in the Palestinian Hospitals' ICUs Amleh, D. Halawani, A. Haj Hussein, M. Alamlih, L. Herd 2025

Icu access to view daylight delirium human health

Virtual Reality Simulation to Improve Postoperative Cardiothoracic Surgical Patient Outcomes Anderson, R. J. Bauer, P. R. Arghami, A. Haney, R. M. Reisdorf, E. M. Baalson, K. Am J Crit Care 2025

Humans *Virtual Reality Male Female Middle Aged Aged *Intensive Care Units Cardiac Surgical Procedures Postoperative Complications/prevention & control Respiration, Artificial

Association of Number of Oral bacteria with Ventilator-Associated Pneumonia and Delirium in Patients in the Intensive Care Unit Arimizu, C. Akahoshi, T. Jinno, T. Furuta, M. Ohashi, A. Takamori, S. Wada, N. J Intensive Care Med 2025

delirium intensive care unit oral bacterial count oral care ventilator-associated pneumonia

Impact of a Collaborative Pharmacist-Cardiovascular Surgeon Protocol for High Risk of Postoperative Delirium on Benzodiazepine Prescription Trends in Hospitalized Patients Asai, Y. Nakano, Y. Yanagawa, T. Takahashi, M. Iwamoto, T. Biol Pharm Bull 2025

Humans *Benzodiazepines/therapeutic use/adverse effects Retrospective Studies *Pharmacists *Delirium/drug therapy/epidemiology/prevention & control Male Female Aged *Postoperative Complications/prevention & control/epidemiology Middle Aged Surgeons Drug Prescriptions/statistics & numerical data Practice Patterns, Physicians’/trends/statistics & numerical data Cardiovascular Surgical Procedures/adverse effects Hospitalization/trends Aged, 80 and over Interrupted Time Series Analysis benzodiazepine insomnia drug interrupted time series prescription trend protocol-based pharmacotherapy management

Supportive Interventions Involving Family Carers of Patients With Delirium Superimposed on Dementia in Hospital: A Scoping Review Ashton-Gough, C. Lynch, J. Goodman, C. Int J Older People Nurs 2025

Humans *Delirium/nursing *Dementia/nursing/complications *Caregivers/psychology Hospitalization Aged Family/psychology carers delirium dementia family caregiving non‐pharmacological interventions

The Misdiagnosis and Underdiagnosis of Hepatic Encephalopathy Bloom, P. P. Clin Transl Gastroenterol 2025

*Hepatic Encephalopathy/diagnosis/etiology Humans *Diagnostic Errors *Liver Cirrhosis/complications/diagnosis *Cognitive Dysfunction/diagnosis/etiology Diagnosis, Differential Delirium/diagnosis/etiology Dementia/diagnosis Risk Factors

Delirium in Neurocritical Care: Uncovering Undisclosed Psychotropic Substance and Medication Use and Stress Exposure by Hair Analysis Bögli, S. Y. Capone, C. Baumgartner, M. R. Quednow, B. B. Kraemer, T. Keller, E. Binz, T. M. Neurocrit Care 2025

Humans Male Female Middle Aged Aged *Delirium/metabolism/etiology/drug therapy *Psychotropic Drugs Adult *Critical Care *Hair Analysis Stress, Psychological/metabolism Hair/chemistry/metabolism Endocannabinoids/metabolism Brain Injuries/metabolism/complications Acute brain injury Delirium Hair analysis Neurocritical care

Sublingual sufentanil after orthopaedic and abdominal surgery: long-term outcome and safety Borck, M. Wandrey, J. D. Spies, C. Tafelski, S. Perioper Med (Lond) 2025

Patient-controlled analgesia Postoperative chronic pain Postoperative delirium Postoperative pain management Sublingual sufentanil tablet system

A single-center prospective cohort study assessing preoperative gait speed assessment as a prognostic tool for morbidity and mortality in frail elderly patients undergoing abdominal surgery Cai, P. P. Gu, L. L. Wang, X. Wu, C. L. Ye, X. H. Zhang, K. Z. Braz J Med Biol Res 2025

Humans Prospective Studies Aged Female Male *Frail Elderly *Walking Speed/physiology *Postoperative Complications/mortality Prognosis Aged, 80 and over Risk Factors *Geriatric Assessment/methods Abdomen/surgery Risk Assessment/methods Predictive Value of Tests Preoperative Period