What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Delirium following total hip or knee arthroplasty: A retrospective, single-center study
- Authors
- Tomite, T. Saito, H. Kijima, H. Hatakeyama, Y. Tazawa, H. Wachi, T. Miyakoshi, N.
- Year
- 2024
- Journal
- J Orthop Sci
- Abstract
BACKGROUND: Delirium is a postoperative complication that may occur in older patients. This study aimed to investigate the incidence of postoperative delirium and its risk factors in patients who had undergone total hip arthroplasty (THA) or total knee arthroplasty (TKA). Few reports have addressed the occurrence of delirium when different methods of pain control are used following total joint arthroplasty, and, therefore, whether its incidence varied depending on differences in pain control was investigated. METHODS: The study included 500 patients (250 cases of THA and 250 of TKA). They were divided into two groups according to the occurrence of postoperative delirium, and risk factors for delirium (patient factors and operative factors) were investigated. As pain control, all patients were given a Ranawat cocktail injection, with the concomitant use of one of epidural anesthesia, nerve block, or intravenous patient-controlled analgesia (IVPCA), and the occurrence of delirium in patients using each method was investigated. RESULTS: On univariate analysis, advanced age, low serum albumin, nonbenzodiazepine use, and anti-parkinsonian drug use were identified as patient factors, and low postoperative minimum hemoglobin, non-use of epidural anesthesia, and non-use of nerve block were identified as operative factors associated with a significantly higher incidence of delirium. A receiver-operating characteristic curve was created for age and delirium, and the cutoff age was 77 years. On binomial logistic regression analysis for age ≥77 years, epidural anesthesia, IVPCA, and nerve block, the only factor associated with the occurrence of delirium was age, irrespective of the type of pain relief used, and the odds ratio for the occurrence of delirium at age ≥77 years was 4.64. CONCLUSIONS: To prevent delirium following total joint arthroplasty, it is important to improve anemia and nutritional status, check and manage regular medications, and provide appropriate pain control while avoiding opioid use.
- PMID
PMID: 39638735
- Keywords
Arthroplasty, Delirium, Pain control
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial | Daojun, Z. Yuling, T. Yingzhe, X. Kowark, A. Coburn, M. Yue, Z. Qixin, Z. Daiying, Z. Tao, P. Xiaoxia, D. | Int J Surg | 2025 |
Humans Double-Blind Method Male Female Middle Aged *Hyperlipidemias/complications *Cyclooxygenase 2 Inhibitors/therapeutic use/administration & dosage *Isoxazoles/therapeutic use Aged *Emergence Delirium/prevention & control/epidemiology/etiology *Postoperative Complications/prevention & control/epidemiology Incidence Adult China/epidemiology *Delirium/prevention & control hyperlipidaemia inflammation parecoxib post operative delirium |
| Validation of Cerebral State Monitor Frequency Power Ratios for Detection of Delirium | DeBurlo, R. Robles, A. Salazar, S. Yang, J. MacDonald, S. Luo, A. Myers, O. Wylie, W. Quinn, D. K. | J Acad Consult Liaison Psychiatry | 2025 |
3d-cam Delirium Eeg biomarkers cerebral state monitor encephalopathy |
| Delirium prevalence, interventions and barriers in intensive care units in German-speaking countries: A retrospective cross-sectional secondary analysis | Exl, M. T. Fischbacher, S. Lindroth, H. Liu, K. Hoffmann, M. Jeitziner, M. M. Nydahl, P. von Haken, R. Krüger, L. Schimböck, F. | Nurs Crit Care | 2025 |
Humans *Delirium/epidemiology Cross-Sectional Studies *Intensive Care Units/statistics & numerical data/organization & administration Prevalence Retrospective Studies Female Male Germany/epidemiology Adult Prospective Studies Middle Aged Aged Surveys and Questionnaires Quality Improvement assessment instruments barriers delirium intensive care unit interventions |
| Association Between Plasma Amyloid-Beta 42 Ratio and Postoperative Delirium in Elderly Patients Undergoing Major Abdominal Surgery: Secondary Analysis of a Randomized Controlled Trial | Fan, Q. Wang, Y. Lu, Z. Wang, L. Yang, X. Zheng, Z. Dong, H. Xiong, L. Lei, C. | Brain Behav | 2025 |
Aged Aged, 80 and over Female Humans Male *Abdomen/surgery *Amyloid beta-Peptides/blood Biomarkers/blood *Delirium/blood/etiology *Peptide Fragments/blood *Postoperative Complications/blood/etiology abdominal surgery amyloid‐beta 42 delirium elderly |
| Clinical effect of using a lower limb warming blanket combined with dexmedetomidine to prevent postoperative delirium and shivering in elderly patients undergoing spinal surgery | Fan, W. Li, M. Yao, Q. Hao, Y. Ji, G. | Expert Rev Med Devices | 2025 |
Dexmedetomidine delirium and shivering elderly patients spinal surgery warming blanket |
| Effect of buccal acupuncture therapy on the incidence of postoperative delirium in older adults undergoing orthopedic lower limb surgery: A randomized controlled trial | Fang, S. Wang, X. Chen, C. Sun, W. Ji, Y. Shao, D. Sun, C. | J Psychosom Res | 2025 |
Humans Aged Male Female *Acupuncture Therapy/methods *Lower Extremity/surgery Incidence *Postoperative Complications/epidemiology/prevention & control *Orthopedic Procedures/adverse effects *Delirium/epidemiology/prevention & control Aged, 80 and over Prospective Studies Pain, Postoperative Buccal acupuncture Elderly Postoperative delirium Postoperative pain |
| Point-of-Care Electroencephalography in Acute Neurological Care: A Narrative Review | Fratangelo, R. Lolli, F. Scarpino, M. Grippo, A. | Neurol Int | 2025 |
artificial intelligence delirium diagnosis diagnostic accuracy non-convulsive status epilepticus management point-of-care EEG portable EEG systems rapid neurological diagnostics stroke detection traumatic brain injury assessment usability in healthcare |
| Interpretable machine learning model for predicting delirium in patients with sepsis: a study based on the MIMIC data | Fu, J. He, A. Wang, L. Li, X. Yu, J. Zheng, R. | BMC Infect Dis | 2025 |
Humans *Delirium/diagnosis/etiology/mortality *Sepsis/complications/mortality Female Male *Machine Learning Aged Middle Aged ROC Curve Aged, 80 and over Organ Dysfunction Scores Risk Factors Delirium MIMIC-IV database Machine learning Nomogram Sepsis |
| A randomized pilot and feasibility trial of live and recorded music interventions for management of delirium symptoms in acute geriatric patients | Golubovic, J. Neerland, B. E. Simpson, M. R. Johansson, K. Baker, F. A. | BMC Geriatr | 2025 |
Humans *Delirium/therapy/psychology/diagnosis Pilot Projects Feasibility Studies Male Female *Music Therapy/methods Aged, 80 and over Aged *Disease Management Treatment Outcome Acute Disease Covid-1 Delirium Feasibility Music Music therapy Severity |
| The Soluble Platelet-Derived Growth Factor β Receptor Induces Postoperative Delirium by Downregulating the Clearance of β-Amyloid in the Brain | Guo, Z. Zhang, C. Wang, X. Chen, W. Guo, Z. | Brain Behav | 2025 |
Humans *Amyloid beta-Peptides/cerebrospinal fluid/metabolism Aged Male Female Middle Aged *Receptor, Platelet-Derived Growth Factor beta/cerebrospinal fluid/metabolism Biomarkers/cerebrospinal fluid Aged, 80 and over *Delirium/cerebrospinal fluid/metabolism/etiology *Postoperative Complications/cerebrospinal fluid/metabolism Peptide Fragments/cerebrospinal fluid/metabolism tau Proteins/cerebrospinal fluid Alzheimer Disease/cerebrospinal fluid/metabolism *Brain/metabolism Arthroplasty, Replacement, Knee/adverse effects Down-Regulation blood–brain barrier cognitive function postoperative delirium sPDGFRβ |
| It's All About Specific Features: Development of Prediction Models for Key Geriatric Risks Across Three Hospital Providers | Gutheil, J. Stampfer, P. Kramer, D. Schrempf, M. Jauk, S. Veeranki, S. P. K. Mrak, P. Pinter, G. Feichtner, F. | Stud Health Technol Inform | 2025 |
Humans *Electronic Health Records *Geriatric Assessment/methods Aged Risk Assessment/methods Aged, 80 and over Female Male Machine Learning Electronic Health Records (EHRs) Geriatric Assessment Prediction Algorithms Risk Assessment |
| From Acute Confusion to Chronic Decline: The Cognitive Impact of Delirium in Older Adults | Hameed, F. Sanborn, V. Nester, C. Daiello, L. A. | R I Med J (2013) | 2025 |
Humans *Delirium/complications/therapy/physiopathology/diagnosis Aged *Confusion/etiology *Cognitive Dysfunction/etiology cognitive impairment delirium dementia geriatric |
| Exploratory randomised trial of tranexamic acid to decrease postoperative delirium in adults undergoing lumbar fusion-a trial stopped early | Hindman, B. J. Olinger, C. R. Woodroffe, R. W. Zanaty, M. Deifelt Streese, C. Zacharias, Z. R. Houtman, J. C. D. Wendt, L. H. Ten Eyck, P. P. O'Connell-Moore, D. J. Ray, E. J. Lee, S. J. Waldschmidt, D. F. Havertape, L. G. Nguyen, L. B. Chen, P. F. Banks, | BJA Open | 2025 |
S100b clinical trial cytokines delirium spinal fusion tranexamic acid |
| Perioperative dexmedetomidine for the prevention of postoperative delirium after cardiac surgery: a systematic review, Bayesian meta-analysis, and Bayesian re-analysis of the DECADE trial | Hunt, T. Payne, T. Brophy, J. M. Irons, J. Wang, A. Y. Cartwright, C. Moran, B. Loadsman, J. A. Sanders, R. D. | Br J Anaesth | 2025 |
Bayesian meta-analysis Bayesian re-analysis cardiac surgery dexmedetomidine postoperative delirium |
| Alterations in the gut microbiome and metabolome in elderly patients with postoperative delirium: A prospective nested case-control study | Huo, J. Han, S. Hao, X. Zhou, Z. Lou, J. Li, H. Cao, J. Yu, Y. Mi, W. Liu, Y. | J Clin Anesth | 2025 |
Geriatric Gut microbiota Orthopedic surgery Postoperative delirium Short-chain fatty acids Targeted metabolomics |
| Association between laboratory data-based frailty index and clinical health outcomes in critically ill older patients: A retrospective correlational study | Ji, H. Lee, J. J. Lee, K. H. | Nurs Crit Care | 2025 |
Humans Retrospective Studies Male Female Aged *Critical Illness/mortality *Frailty/diagnosis Delirium/epidemiology Intensive Care Units Hospital Mortality Aged, 80 and over Republic of Korea *Geriatric Assessment/methods *Frail Elderly/statistics & numerical data delirium electronic health records frailty mortality |
| Psychometric properties of the Chinese version of difficulty scale for nurses who care for patients with delirium in the intensive care unit | Jiang, T. Wang, Y. Yang, W. Chen, H. Wang, N. | BMC Nurs | 2025 |
Delirium Intensive care units Nurse Reliability Scale Validity |
| The effects of del Nido cardioplegia combined with dexmedetomidine on cardiac surgery with cardiopulmonary bypass | Jiang, X. Zhou, X. Yao, L. Li, L. Gu, T. | Perfusion | 2025 |
cardiac surgery cardiopulmonary bypass myocardial preservation postoperative atrial fibrillation postoperative delirium |
| A Low Life's Simple 7 Score Is an Independent Risk Factor for Postoperative Delirium After Total Knee Arthroplasty | Joo, Y. B. Kim, Y. M. Lee, W. Y. Park, Y. C. Park, J. Y. Lee, C. S. | Medicina (Kaunas) | 2025 |
Humans *Arthroplasty, Replacement, Knee/adverse effects Male Female Retrospective Studies Aged Risk Factors *Delirium/etiology/diagnosis Middle Aged *Postoperative Complications/etiology ROC Curve Risk Assessment/methods Aged, 80 and over Life’s Simple 7 score osteoarthritis postoperative delirium risk factor total knee arthroplasty |
| Effect of Esketamine on Postoperative Delirium and Inflammatory Response in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting: A Randomized Controlled Study | Ju, L. Y. Liu, G. Q. Yuan, L. Lyu, L. Su, Y. Liu, A. J. | J Cardiothorac Vasc Anesth | 2025 |
esketamine off-pump coronary artery bypass postoperative delirium postoperative inflammation s-ketamine |
| Factors predicting delirium among hospitalized older adults in an urban area, Thailand: A prospective cohort study | Kaveenuntachai, D. Prueksaanantakal, N. Benyapad, P. Chinpinkleaw, P. Jiojinda, S. | Belitung Nurs J | 2025 |
Thailand cognitive dysfunction delirium hospitalization internal medicine older adults risk factors urban hospitals |
| Effects of Virtual Reality Meditation on Sleep and Delirium in ICU Patients: A Randomized Controlled Trial | Kim, S. Kang, J. | Comput Inform Nurs | 2025 |
Delirium Icu Meditation Sleep Virtual reality |
| Impact of consultation liaison services on postoperative psychotropic drug use | Kitaoka, R. Ayani, N. Uramatsu, T. Yamazoe, E. Okazaki, T. Ogawa, K. Yokoi, T. Takeda, K. Nakai, K. Oya, N. Nakamura, T. Horiguchi, G. Narumoto, J. | J Psychosom Res | 2025 |
Humans Male Female *Referral and Consultation Middle Aged *Psychotropic Drugs/therapeutic use/adverse effects Aged *Postoperative Complications/drug therapy *Antipsychotic Agents/therapeutic use *Delirium/drug therapy Adult *Postoperative Care Adverse drug events Antipsychotics Consultation liaison Delirium Postoperative Psychotropic |
| Association of postoperative delirium with visual acuity after ophthalmic surgeries under local anesthesia | Koga, Y. Kitazawa, K. Shinozaki, G. Yoshii, K. Hughes, J. B. Yamashita, Y. Kojima, K. Ueno, M. Kinoshita, S. Sotozono, C. | Jpn J Ophthalmol | 2025 |
Delirium Local anesthesia Low visual acuity Ophthalmic surgeries Visual impairment |
| Delirium pathophysiology in cancer: neurofilament light chain biomarker - narrative review | Kruize, Z. van Campen, I. Vermunt, L. Geerse, O. Stoffels, J. Teunissen, C. van Zuylen, L. | BMJ Support Palliat Care | 2025 |
Humans *Delirium/physiopathology/etiology/diagnosis *Neoplasms/complications/physiopathology Biomarkers/blood *Neurofilament Proteins/blood/metabolism/analysis Cancer Delirium |
| Development of a checklist for systematic screening of precipitating factors in older patients admitted to hospital with delirium | Lafuente-Lafuente, C. Candia, E. H. Pautas, E. Freund, Y. Oquendo, B. Belmin, J. | Eur Geriatr Med | 2025 |
Checklist Clinical diagnosis Delirium Etiology Older people Precipitating factors |
| Incidence and predictors of postoperative delirium following remimazolam administration: a systematic review and meta-analysis of 29 randomized trials | Li, C. Wei, L. Gong, H. Yuan, X. | BMC Anesthesiol | 2025 |
Humans Incidence Randomized Controlled Trials as Topic *Benzodiazepines/adverse effects/administration & dosage *Postoperative Complications/epidemiology/chemically induced *Emergence Delirium/epidemiology/chemically induced *Delirium/epidemiology/chemically induced *Hypnotics and Sedatives/adverse effects/administration & dosage Delirium Incidence Rate Moderators Remimazolam |
| Optimal Dose of Intranasal Insulin Administration for Reducing Postoperative Delirium Incidence in Older Patients Undergoing Hip Fracture Surgery | Li, Y. Zhang, Y. Ren, Y. Liu, H. | Am J Geriatr Psychiatry | 2025 |
Postoperative delirium hip fracture insulin intranasal administration older patients |
| Knowledge Uncertainty Estimation for Reliable Clinical Decision Support: A Delirium Risk Prognosis Case Study | Lindenmeyer, A. Veeranki, S. Franke, S. Neumuth, T. Kramer, D. Schneider, D. | Stud Health Technol Inform | 2025 |
Humans *Delirium/diagnosis *Decision Support Systems, Clinical Uncertainty Prognosis Risk Assessment/methods *Neural Networks, Computer Artificial intelligence Clinical decision support systems Delirium |
| Preventive effects of perioperative drug injection on postoperative delirium after hip fracture surgery: a systematic review and meta-analysis | Lu, J. Weng, X. Ma, J. Zhang, T. Ming, H. Ma, X. | Am J Transl Res | 2025 |
Hip fracture delirium injection of medication meta-analysis perioperative period |
| Relationship between preoperative high arterial blood lactate level and delirium after deep brain stimulation surgery in Parkinson's disease | Lu, W. Rao, M. Lu, L. Li, P. Dou, X. Bian, J. Deng, X. | Front Aging | 2025 |
Parkinson’s disease deep brain stimulation lactate level postoperative delirium subthalamic nucleus |
| Metformin's impact on delirium in diabetic cardio surgery patients | Lu, Z. Sun, M. Chen, W. M. Lv, S. Fu, N. Yang, Y. Wang, Y. Miao, M. Wu, S. Y. Zhang, J. | J Anesth | 2025 |
Cardiovascular surgery Metformin Postoperative delirium Prognostic factors Type 2 diabetes mellitus |
| The Role of Quetiapine in Treating Delirium in Critical Care Settings: A Narrative Review | Menozzi, A. Gotti, M. Mantovani, E. A. Galimberti, A. Umbrello, M. Mistraletti, G. Sabbatini, G. Pezzi, A. Formenti, P. | J Clin Med | 2025 |
Icu antipsychotics in ICU delirium quetiapine |
| Delirium as a Determinant of Long-Term Cognitive Dysfunction in the Context of Post-intensive Care Syndrome: A Prospective Study in a Latin American Environment | Mesa, P. Kotfis, K. Lecor, C. Leyes, C. Banchero, A. De Mattos, S. Somma, V. Orellano, M. Favretto, S. Barros, M. | Cureus | 2025 |
cam-icu cognitive cognitive impairment delirium medical intensive care unit (micu) physical sequelae post intensive care psychological |
| Development of a curriculum for interdisciplinary e-learning on delirium in nursing homes-a modified Delphi study | Molitor, V. Seiters, J. C. Vollmar, H. C. Palm, R. | BMC Med Educ | 2025 |
Humans Delphi Technique *Delirium/therapy/diagnosis *Curriculum *Nursing Homes Clinical Competence *Computer-Assisted Instruction/methods *Education, Distance/methods Curriculum development Delirium Delphi study E-Learning Health care professionals Nursing home |
| Association between low income and ICU delirium among critically ill older patients: A retrospective cohort study in Japan | Nishizawa, T. Nawa, N. Mizuno, A. Suzuki, T. Arioka, H. Fujiwara, T. | Anaesth Crit Care Pain Med | 2025 |
Delirium Income Intensive care units Social determinants of health |
| Association between preoperative anemia and postoperative delirium in elderly patients undergoing non-cardiac surgery: a retrospective observational study | Oh, A. R. Park, J. Kim, C. S. Lee, S. M. Yoo, S. Y. | Korean J Anesthesiol | 2025 |
Anemia Delirium Geriatrics Hemoglobin Mortality Surgery |
| Epidemiology and assessments of delirium in nursing homes and rehabilitation facilities: a cross-country perspective | Ornago, A. M. Pinardi, E. Ferrara, M. C. Timmons, S. Okoye, C. Finazzi, A. Mazzola, P. Nydahl, P. von Haken, R. Lindroth, H. Liu, K. Morandi, A. Bellelli, G. | Eur Geriatr Med | 2025 |
Delirium Epidemiology Long-term care Nursing homes Rehabilitation |
| Delirium in Elderly Hospitalized Patients: Analyzing Clinical and Social Determinants in a Colombian Retrospective Cohort | Ospina-Lehmann, A. Castañeda-Gómez, M. C. Pabón-Martínez, E. J. Vigoya-Aponte, J. P. Orozco-Castro, S. Chavarro-Carvajal, D. A. Cano-Gutiérrez, C. A. | Int J Geriatr Psychiatry | 2025 |
Humans Female Male *Delirium/epidemiology Colombia/epidemiology Aged, 80 and over Retrospective Studies Aged *Hospitalization/statistics & numerical data Risk Factors Malnutrition/epidemiology *Social Determinants of Health/statistics & numerical data Dementia/epidemiology Prevalence Deglutition Disorders/epidemiology Age Factors Logistic Models delirium social determinants of health sociodemographic factors |
| Neuron-specific enolase and Tau protein as biomarkers for sepsis-associated delirium: a cross-sectional pilot study | Pinto, A. A. S. Carvalho, M. M. Santos, J. B. Silva, R. S. D. Barbeiro, H. V. Gómez, L. M. G. Maia, I. W. A. Marchini, J. F. M. Garcez, F. B. Avelino-Silva, T. J. Soler, L. M. Mochetti, M. M. Souza, H. P. Alencar, J. C. G. | Einstein (Sao Paulo) | 2025 |
Humans *Phosphopyruvate Hydratase/blood Pilot Projects Cross-Sectional Studies Biomarkers/blood Male Female *Delirium/blood/etiology/diagnosis *tau Proteins/blood Aged *Sepsis/complications/blood Middle Aged Aged, 80 and over Emergency Service, Hospital Sensitivity and Specificity Reference Values |
| The S-shaped association between mNUTRIC score and delirium in septic patients in the intensive care unit: A retrospective cohort study using the MIMIC-IV database | Qu, J. Lv, C. Zhang, X. Ren, X. Li, Y. Wu, C. | Shock | 2025 |
Mimic-iv S-shaped delirium mNUTRIC score retrospective cohort study |
| Associations between anaesthetic dose-adjusted intraoperative EEG alpha power, processing speed, and postoperative delirium: analysis of data from three prospective studies | Reese, M. Wright, M. C. Roberts, K. C. Browndyke, J. N. Bennett, M. Acker, L. Devinney, M. J. Reekes, T. H. Waligorska, T. Shaw, L. M. Blennow, K. Zetterberg, H. Cohen, H. J. Mathew, J. P. Whitson, H. E. Westover, M. B. Woldorff, M. G. Berger, M. | Br J Anaesth | 2025 |
Alzheimer’s disease Eeg alpha power anaesthesia cerebrospinal fluid perioperative neurocognitive disorder |
| Prospective external validation of the automated PIPRA multivariable prediction model for postoperative delirium on real-world data from a consecutive cohort of non-cardiac surgery inpatients | Reeve, K. A. Schmutz Gelsomino, N. Venturini, M. Buddeberg, F. Zozman, M. Stocker, R. Kedda, M. A. Meier, P. Möller, M. Wildhaber, S. P. Dodsworth, B. T. | BMJ Health Care Inform | 2025 |
Humans Male Female Aged *Delirium/prevention & control/epidemiology/diagnosis Risk Assessment/methods Prospective Studies *Postoperative Complications/prevention & control/epidemiology Middle Aged *Algorithms Switzerland Inpatients Aged, 80 and over Artificial intelligence Decision Support Systems, Clinical Electronic Health Records Machine Learning Nursing |
| Long-Term Care Ownership and Operator Factors in Probable Delirium: A Population-Based Study From Ontario, Canada | Roberts, R. Tanuseputro, P. Lawlor, P. Bush, S. H. Watt, C. L. Pugliese, M. Casey, G. Knoefel, F. Thavorn, K. Momoli, F. Webber, C. | J Am Med Dir Assoc | 2025 |
Long-term care delirium nursing homes |
| Frailty as a mediator of postoperative delirium in older adults undergoing orthopedic surgery: A causal mediation analysis | Roopsawang, I. Aree-Ue, S. Thompson, H. Numthavaj, P. | Int J Nurs Stud Adv | 2025 |
Frailty Mediation analysis Older adults Orthopedic surgery Postoperative delirium Preoperative pain |
| Risk Stratification of QTc Prolongation in Critically Ill Patients Receiving Antipsychotics for the Management of Delirium Symptoms | Sadlonova, M. Beach, S. R. Funk, M. C. Rosen, J. H. Ramirez Gamero, A. F. Karlson, R. A. Huffman, J. C. Celano, C. M. | J Intensive Care Med | 2025 |
Humans *Antipsychotic Agents/adverse effects/therapeutic use *Delirium/drug therapy *Long QT Syndrome/chemically induced Critical Illness Risk Assessment Risk Factors Female Intensive Care Units Male Electrocardiography QTc prolongation agitation antipsychotics drug safety neuroleptics |
| Perioperative Use of Melatonin in Joint Arthroplasty: A Critical Systematic Review of Randomized Clinical Studies | Saleh, A. K. Ramadan, H. S. I. Abdelhameed, S. M. Ezzelarab, M. Elsawy, A. G. S. Ahmed, S. S. Abdel-Aziz, M. M. Elshehawy, N. A. Zahran, G. E. Ibrahiem, N. M. Alshahrani, N. N. | J Pain Palliat Care Pharmacother | 2025 |
Arthroplasty melatonin postoperative delirium postoperative pain postoperative sleep disturbance |
| Agitation management strategies for older adults in the emergency department or with emergency medical services: A scoping review | Shah, F. I. Lew, G. Chawdhry, Z. Reich, K. Crowder, K. Lorenzetti, D. L. McGillivray, M. Goodarzi, Z. | Am J Emerg Med | 2025 |
Agitation Delirium Dementia Emergency department Restraints |
| Comparative analysis of inflammatory markers as predictive markers for postoperative delirium in cardiac surgery patients: an observational study | Shan, L. Zheng, K. Dai, W. Wang, Y. Hao, P. | Front Med (Lausanne) | 2025 |
cardiac surgery monocyte-to-lymphocyte ratio neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio postoperative delirium |
| Association between admission Braden Skin Score and delirium in surgical intensive care patients: an analysis of the MIMIC-IV database | Shang, M. Shang, A. Xu, Y. | Front Neurol | 2025 |
Braden Skin Score MIMIC-IV database delirium risk factors surgical intensive care unit |
| Machine learning approach for the prediction of 30-day mortality in patients with sepsis-associated delirium | Shen, X. Shang, D. Sun, W. Ru, S. | PLoS One | 2025 |
Humans Male *Machine Learning Female Aged *Delirium/mortality/etiology *Sepsis/complications/mortality Middle Aged Aged, 80 and over Risk Factors Prognosis Algorithms |
| Association between retinal layer thickness and postoperative delirium in older patients | Shi, Z. Ma, X. Tang, T. Wang, M. Zheng, H. Chen, Y. Hu, J. Mueller, A. Houle, T. T. Marcantonio, E. R. Xie, Z. Shen, Y. | Gen Psychiatr | 2025 |
Cross-Sectional Studies Geriatric Psychiatry |
| Delirium Prevention and Management in Older Adults in the Emergency Department | Skains, R. M. Lee, S. Han, J. H. | Emerg Med Clin North Am | 2025 |
Humans *Delirium/prevention & control/therapy/diagnosis *Emergency Service, Hospital Aged Antipsychotic Agents/therapeutic use Delirium Emergency department Geriatrics Intervention Management Prevention |
| Evaluating a customised large language model (DELSTAR) and its ability to address medication-related questions associated with delirium: a quantitative exploratory study | Spagl, K. T. Watson, E. W. Jatowt, A. Weidmann, A. E. | Int J Clin Pharm | 2025 |
Clinical pharmacy information systems Delirium Drug prescribing Intelligence artificial Intelligence machine Patient safety |
| Postoperative Delirium and Cognitive Dysfunction After Cardiac Surgery: The Role of Inflammation and Clinical Risk Factors | Staicu, R. E. Vernic, C. Ciurescu, S. Lascu, A. Aburel, O. M. Deutsch, P. Rosca, E. C. | Diagnostics (Basel) | 2025 |
Crp Il-6 Il17-a Nlr Sii Siri cardiac surgery inflammation neuroinflammation postoperative cognitive dysfunction postoperative delirium |
| Evaluating the Chinese versions of delirium assessment scales: a diagnostic systematic review | Tang, C. Zhong, J. Wang, X. Zhu, F. Wang, B. Zhang, Y. Hu, D. | BMC Psychiatry | 2025 |
Humans *Delirium/diagnosis China Reproducibility of Results *Psychiatric Status Rating Scales/standards Translations Assessment tools Chinese adaptation Delirium |
| Development and Validation of Subsyndromal Delirium Prediction Model in Patients With Advanced Malignant Tumor: A Case-Control Study | Wang, P. Xiao, W. | Cancer Nurs | 2025 |
Humans Female Male *Neoplasms/complications Middle Aged *Delirium/diagnosis/etiology Aged Case-Control Studies Risk Assessment/methods Adult Risk Factors ROC Curve China Logistic Models Case-control Efficacy Influencing factors Malignant tumor Prediction model Subsyndromal delirium Validation group |
| Research progress of postoperative delirium in neurosurgery | Wang, X. J. | World J Psychiatry | 2025 |
Neurological dysfunction Neurosurgery Postoperative delirium Research progress Surgery |
| The Causal Relationship Between Neurotrophic Factors and Delirium: A Mendelian Randomization Study | Wu, H. Jiang, R. Huang, X. Hu, X. | Brain Behav | 2025 |
Humans Mendelian Randomization Analysis/methods *Delirium/genetics/metabolism *Nerve Growth Factors/genetics/metabolism Genome-Wide Association Study Risk Factors Polymorphism, Single Nucleotide Mendelian randomization delirium glial cell‐derived neurotrophic factor neurotrophic factors |
| Preoperative Plasma p-tau231，p-tau181 and p-tau217 are associated with Postoperative Delirium: a prospective study | Wu, L. X. Su, J. B. Li, G. L. Zhuang, M. Sun, H. J. Zhang, J. R. | J Gerontol A Biol Sci Med Sci | 2025 |
Tau biomarker delirium older adults postoperative |
| Predicting the Risk of Postoperative Delirium in Patients Undergoing Lobectomy: Development and Assessment of a Novel Nomogram | Xue, Y. Yu, R. Wang, W. Li, L. Tao, J. Zhuang, Q. Li, X. Zhang, Y. | Thorac Cardiovasc Surg | 2025 |
Delirium, Postoperative delirium, Surgery, Lobectomy |
| Ability of clock drawing errors on Mini-Cog test to predict development of delirium after major urological cancer surgery | Yajima, S. Nakanishi, Y. Matsumoto, S. Okubo, N. Tanabe, K. Kataoka, M. Masuda, H. | Curr Urol | 2025 |
Cognitive dysfunction Delirium Dementia Robotic surgery Urology |
| Correlation of intraoperative blood pressure variability and postoperative delirium in elderly hip fracture surgery | Yang, P. Fan, Y. Tang, W. | Sci Rep | 2025 |
Humans *Hip Fractures/surgery/physiopathology Male Female Aged Aged, 80 and over *Delirium/etiology/physiopathology *Blood Pressure/physiology Retrospective Studies *Postoperative Complications/etiology/physiopathology Risk Factors Intraoperative Period Blood pressure variability Geriatric Hip fracture Postoperative delirium Risk factor |
| The relationship between postoperative delirium and plasma amyloid beta oligomer | Yang, Y. Jung, K. J. Kwak, Y. T. | Sci Rep | 2025 |
Humans Male *Amyloid beta-Peptides/blood Female Aged *Delirium/blood/etiology *Postoperative Complications/blood/etiology *Anesthesia, General/adverse effects Aged, 80 and over Biomarkers/blood Alzheimer Disease/blood Alzheimer’s disease Amyloid beta oligomer MDS-Oaβ Postoperative delirium |
| Association between red cell distribution width-to-albumin ratio and short-term mortality in patients with sepsis-associated delirium: a retrospective study from the MIMIC-IV database | Yao, S. Zhang, G. Ni, L. | BMC Anesthesiol | 2025 |
Humans Retrospective Studies Male Female *Delirium/mortality/blood/etiology Aged *Sepsis/mortality/complications/blood Middle Aged Databases, Factual Intensive Care Units *Erythrocyte Indices/physiology Cohort Studies *Serum Albumin/analysis/metabolism Albumin Delirium Red cell distribution width Sepsis Short-term mortality |
| Associations between triglyceride-glucose indices and delirium risk in critically ill patients with acute kidney injury: a retrospective study | Zhang, W. Jin, T. Hu, X. | Front Endocrinol (Lausanne) | 2025 |
Humans *Acute Kidney Injury/blood/complications Male Female *Delirium/blood/etiology/epidemiology Retrospective Studies Middle Aged Critical Illness Aged *Triglycerides/blood *Blood Glucose/analysis/metabolism Risk Factors Incidence Biomarkers/blood Cox proportional hazard acute kidney injury delirium insulin resistance intensive care unit triglyceride-glucose indices |
| Comparison of the efficacy of pharmacological interventions for the prevention of delirium: A systematic review and network meta-analysis | Zhou, X. Yin, C. | Med Clin (Barc) | 2025 |
Delirium Dexmedetomidine Network meta-analysis Systematic review |
| Efficacy of perioperative dexmedetomidine on postoperative pain and neurocognitive functions in orthopaedic surgery: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials | Zhang, X. Leng, Y. Yuan, X. Yang, Y. Zhou, C. Liu, H. | Int J Surg | 2025 |
orthopedic surgery, postoperative pain, postoperative cognitive dysfunction, dexmedetomidine, postoperative delirium |
| Elevated TDP-43 serum levels associated with postoperative delirium following major cardiac surgery | Simon, C. Graves, O. K. Akeju, O. McKay, T. B. | Brain Behav Immun Health | 2025 |
Postoperative delirium, vulnerable patients, major cardiac surgery, prodromal dementia, TDP-43 |
| Empowering Family Care Partners to Optimize Delirium Care for Persons Living With Dementia | Shrestha, P. Fick, D. M. Susman, A. Akter, N. | Res Gerontol Nurs | 2025 |
Family care partners, caregiver priorities, delirium, dementia, delirium superimposed on dementia |
| Impact of Implantable Hearing Devices on Delirium Risk in Patients with Hearing Loss: A National Database Study | Hambach, B. Patel, J. Nunes, K. Sina, E. M. Llerena, P. Knops, A. Chiffer, R. C. Hunter, J. B. | Otol Neurotol | 2025 |
Delirium, hearing loss, implantable hearing rehabilitation devices |
| Cerebrospinal fluid biomarkers of neuroinflammation and postoperative neurocognitive disorders in patients undergoing orthopedic surgery | Feng, H. Liu, Y. Wang, X. Wang, C. Wang, T. | Int J Surg | 2025 |
Postoperative Neurocognitive Disorders, postoperative complications, recovery, cerebrospinal fluid, biomarkers, orthopedic surgery, |
| What are the experiences and support needs of district nurses caring for terminally ill people with delirium at home? A qualitative study | Arnold, E. Lugton, J. Spiller, J. Finucane, A. | BMC Palliat Care | 2025 |
Humans *Qualitative Research *Delirium/nursing Scotland Female *Terminally Ill/psychology Male Middle Aged Adult Needs Assessment Home Care Services/standards Nurses/psychology Community Confusion Delirious Delirium Detection District nurses Home Management Palliative Prevention Terminal |
| ICU nurses' perceptions on family involvement in delirium care for postoperative cardiac surgery patients: A qualitative study | Azimzadeh, D. Lapierre, A. Bouaouina, Z. Williamson, D. Mailhot, T. Arbour, C. | Intensive Crit Care Nurs | 2025 |
Cardiac surgery Delirium Family involvement Icu Nurse’s perception |
| Efficacy and safety of gastrodin in preventing postoperative delirium following cardiac surgery: a randomized placebo controlled clinical trial | Bai, Y. X. Wu, H. L. Xie, W. L. Li, X. Han, J. J. Liu, J. Chen, S. Q. Yin, P. Dong, N. G. Wu, Q. P. | Crit Care | 2025 |
Humans *Benzyl Alcohols/therapeutic use/adverse effects Female Male *Glucosides/therapeutic use/adverse effects Middle Aged Double-Blind Method Aged *Delirium/prevention & control/etiology *Postoperative Complications/prevention & control Cardiac Surgical Procedures/adverse effects Adult Cardiac surgery Delirium Gastrodin |
| Neuroimaging biomarkers on routine Computed Tomography (CT) after acute stroke and their association with post-stroke delirium: A cohort study | Barugh, A. Farrall, A. Ferguson, K. Shenkin, S. MacLullich, A. Mead, G. | J Stroke Cerebrovasc Dis | 2025 |
Brain imaging Cistern ambiens Computed tomography Delirium Stroke |
| Preoperative prediction models for postoperative delirium in cardiac surgery patients - a scoping review | Blakoe, M. Olsen, D. B. Noergaard, M. W. | Contemp Nurse | 2025 |
cardiac surgery delirium postoperative delirium prediction prognostic |
| A Deep-Learning-Based Approach for Delirium Monitoring in ICU Patients Using Thermograms | Blase, D. Chayeb, O. Chan, P. Y. Leonhardt, S. Lueken, M. | Annu Int Conf IEEE Eng Med Biol Soc | 2024 |
Humans *Delirium/diagnosis *Intensive Care Units *Deep Learning *Thermography/methods Monitoring, Physiologic/methods Male Female Aged Neural Networks, Computer Middle Aged |
| Exploring Post-Anaesthesia Care Unit Nurses' Experiences Post Participation in a Delirium Care for Older People Education Intervention: A Qualitative Study | Bowden, A. Wilson, V. Bresolin, J. Nealon, J. Traynor, V. | Int J Older People Nurs | 2025 |
Humans *Qualitative Research *Delirium/nursing Aged Female Male *Clinical Competence Postanesthesia Nursing Nursing Staff, Hospital/education/psychology Geriatric Nursing/education Postoperative Complications/nursing Middle Aged Adult delirium nursing education nursing practice older people professional development simulation‐based‐education |
| Hemoglobin to red cell distribution width ratio predicts postoperative delirium in older patients undergoing hip fracture surgery: A retrospective cohort study | Cao, X. Zhang, H. Li, Y. Liu, M. He, J. Li, J. | Geriatr Gerontol Int | 2025 |
Humans *Hip Fractures/surgery Male Female Retrospective Studies Aged Aged, 80 and over *Hemoglobins/analysis *Delirium/blood/etiology/diagnosis *Postoperative Complications/blood/diagnosis Predictive Value of Tests *Erythrocyte Indices ROC Curve hemoglobin to red blood cell distribution width ratio hip fracture surgery older patients postoperative delirium risk factor |
| Mapping the Nursing Literature on Postoperative Delirium: A Bibliometric Analysis | Cetinkaya, M. M. Taylan, S. Eti Aslan, F. | J Perianesth Nurs | 2025 |
bibliometric analysis delirium nursing surgery |
| Mapping the Nursing Literature on Postoperative Delirium: A Bibliometric Analysis | Cetinkaya, M. M. Taylan, S. Eti Aslan, F. | J Perianesth Nurs | 2025 |
bibliometric analysis delirium nursing surgery |
| Haloperidol in treating delirium, reducing mortality, and preventing delirium occurrence: Bayesian and frequentist meta-analyses | Cheng, S. L. Hsu, T. W. Kao, Y. C. Yu, C. L. Thompson, T. Carvalho, A. F. Stubbs, B. Tseng, P. T. Hsu, C. W. Yang, F. C. Tu, Y. K. Liang, C. S. | Crit Care | 2025 |
*Haloperidol/therapeutic use/adverse effects Humans *Delirium/drug therapy/prevention & control *Bayes Theorem Antipsychotic Agents/therapeutic use/adverse effects Intensive Care Units/statistics & numerical data Mortality/trends Bayesian meta-analysis Delirium Haloperidol Intensive care unit patients Mortality |
| Delirium management in 2024: A status check and evolution in clinical practice since 2016 | Coolens, O. Kaltwasser, A. Melms, T. Monke, S. Nydahl, P. Pelz, S. von Haken, R. Hasemann, W. | Intensive Crit Care Nurs | 2025 |
Best practice Critical care Culture Delirium Delirium management Encephalopathy |
| Machine Learning-Based Prediction of Delirium and Risk Factor Identification in Intensive Care Unit Patients With Burns: Retrospective Observational Study | Esumi, R. Funao, H. Kawamoto, E. Sakamoto, R. Ito-Masui, A. Okuno, F. Shinkai, T. Hane, A. Ikejiri, K. Akama, Y. Gaowa, A. Park, E. J. Momosaki, R. Kaku, R. Shimaoka, M. | JMIR Form Res | 2025 |
Humans *Delirium/diagnosis/epidemiology *Machine Learning Male Female Middle Aged Retrospective Studies *Intensive Care Units *Burns/complications Risk Factors Adult Aged ROC Curve Risk Assessment/methods Ai artificial intelligence burns delirium intensive care unit machine learning prediction model |
| The perceptions of European geriatricians on the co-occurrence and links between dementia, delirium and frailty | Faherty, M. Curtin, C. Bellelli, G. Brunetti, E. Bo, M. Morandi, A. Cherubini, A. Fedecostante, M. Ferrara, M. C. Coin, A. Shenkin, S. D. Soysal, P. Timmons, S. | Eur Geriatr Med | 2025 |
Attitudes Delirium Dementia Frailty Prevalence Risk factors |
| Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery | Fallon, J. M. Hashemaghaie, M. Peterson, C. E. Tran, D. Wu, S. R. Valdes, J. M. Pedicini, N. M. Adams, M. E. Soltis, M. Mansour, W. Wright, M. C. Raghunathan, K. Treggiari, M. M. Sasannejad, C. Devinney, M. J. | BMJ Open | 2025 |
Humans Double-Blind Method *Azepines/therapeutic use Aged *Triazoles/therapeutic use *Delirium/prevention & control *Postoperative Complications/prevention & control Randomized Controlled Trials as Topic Orexin Receptor Antagonists/therapeutic use/administration & dosage Male Sleep Aids, Pharmaceutical/therapeutic use/administration & dosage Female Sleep/drug effects Clinical Trial Delirium Sleep medicine |
| Efficacy and safety of care bundles in the treatment of delirium in ICU patients: a meta-analysis and systemic review | Fang, D. Zeng, L. Kuang, F. | BMC Nurs | 2025 |
Care bundles Delirium Icu Meta-analysis |
| Delirium prevention in hospices: Opportunities and limitations - A focused ethnography | Featherstone, I. Johnson, M. J. Sheldon, T. Kelley, R. Hawkins, R. Bravington, A. Callin, S. Dixon, R. Obita, G. Siddiqi, N. | Palliat Med | 2025 |
Humans *Delirium/prevention & control *Anthropology, Cultural Male Female Hospices Aged Middle Aged Hospice Care United Kingdom Adult Aged, 80 and over Attitude of Health Personnel Qualitative Research Delirium palliative care |
| Amplitude coupling is altered in delirium of various etiologies: Results from a retrospective multi-center case-control EEG study | Fleischmann, R. Mengel, A. Stam, C. J. Leroy, S. Schneider, P. Slooter, A. J. C. Ehler, J. van Dellen, E. | Clin Neurophysiol | 2025 |
Amplitude-amplitude coupling Connectivity Delirium Electroencephalography Postoperative Stroke |
| Effect size estimates of risk factors for post-intensive care syndrome: A systematic review and meta-analysis | Gao, S. Liang, X. Pan, Z. Zhang, X. Zhang, L. | Intensive Crit Care Nurs | 2025 |
Humans Risk Factors *Intensive Care Units/organization & administration Female Male Critical Care/methods/psychology Critical Illness Intensive care units Meta-analysis Post intensive care syndrome Survivors |
| Health-care staff perspectives in optimising delirium prevention using data-driven interventions | Gokhale, S. Garth, B. Webb-St Mart, M. Taylor, D. Zeps, N. Enticott, J. Teede, H. Reeder, S. | Australas J Ageing | 2025 |
Humans *Delirium/prevention & control/diagnosis *Qualitative Research *Attitude of Health Personnel Interviews as Topic Risk Assessment Male Female Health Knowledge, Attitudes, Practice Health Personnel/psychology Risk Factors data‐driven optimisation delirium prevention health services research learning health system pre‐implementation factors |
| Frailty screening of older patients in emergency departments in Norway | Goll, J. B. Saga, E. Johnsen, B. Hoff, O. M. Martinaityte, I. Halvorsen, D. S. Søvde Å, K. Gundersen, M. D. Wang-Hansen, M. | Tidsskr Nor Laegeforen | 2025 |
Humans Norway/epidemiology Aged Female Aged, 80 and over Male *Emergency Service, Hospital/statistics & numerical data *Frail Elderly/statistics & numerical data *Frailty/diagnosis/epidemiology *Geriatric Assessment/methods Delirium/diagnosis/epidemiology Mass Screening |
| Delirium following mechanical thrombectomy for ischemic stroke - individuals at risk, imaging biomarkers and prognosis | Hahn, M. Brockstedt, L. Gröschel, S. Geschke, K. Grauhan, N. F. Brockmann, M. A. Othman, A. E. Gröschel, K. Uphaus, T. | Front Aging Neurosci | 2025 |
atrophy complications delirium endovascular stroke therapy mechanical thrombectomy prognosis stroke |
| Remifentanil use in critically Ill patients requiring mechanical ventilation is associated with increased delirium-free days: a retrospective study | Haruna, J. Sasaki, A. Kazuma, S. | Int J Emerg Med | 2025 |
Critical illness Delirium Remifentanil |
| Outcomes of Older Adults With Delirium Discharged From the Emergency Department | Howick, A. S. Thao, P. Carpenter, K. P. Boie, M. A. Maia, I. W. A. Mullan, A. F. Bower, S. M. Palmer, A. K. Carpenter, C. R. Liu, S. W. Jeffery, M. M. Bellolio, F. | Ann Emerg Med | 2025 |
Dementia Frailty Geriatrics, delirium Mortality Older adult |
| Association between intraoperative electroencephalograph complexity index and postoperative delirium in elderly patients undergoing orthopedic surgery: a prospective cohort study | Hu, X. Y. Dai, Y. C. Zhu, L. Y. Yang, J. J. Sun, J. Ji, M. H. | J Anesth | 2025 |
Complexity Eeg Electroencephalogram Postoperative delirium |
| Hypnotic drug use and intraoperative fluid balance associated with postoperative delirium following pancreatic surgery: A retrospective, observational, single-center study | Huang, Z. H. Zhang, J. Xu, X. Y. Wang, Y. Lu, X. J. Luo, Y. | PLoS One | 2025 |
Humans Male Female Retrospective Studies Aged Middle Aged *Delirium/etiology *Postoperative Complications/etiology Risk Factors *Hypnotics and Sedatives/adverse effects Water-Electrolyte Balance Pancreas/surgery |
| Natriuretic Peptides as a Predictor for Delirium After Cardiac Surgery: A Prospective Observational Study | Huisinga, C. Struck, E. Mihatsch, L. Heyn, J. Hagl, C. Zwissler, B. von Dossow, V. Saller, T. | J Clin Med | 2025 |
biomarker cardiac surgery delirium natriuretic peptides neurocognitive disorders quality of life short form 36 questionnaire |
| Albumin/fibrinogen ratio (AFR): a significant predictor of postoperative delirium in older patients undergoing non-neurosurgical and non-cardiac surgery | Huo, J. Song, Y. Lu, J. Dou, G. Chen, H. Mi, W. Yu, Y. Liu, Y. | BMC Geriatr | 2025 |
Humans Female Aged Male Retrospective Studies *Fibrinogen/analysis/metabolism *Postoperative Complications/diagnosis/epidemiology/blood *Delirium/diagnosis/blood/epidemiology Aged, 80 and over Prognosis Serum Albumin/metabolism Surgical Procedures, Operative/adverse effects Biomarkers/blood Predictive Value of Tests Risk Factors Aged patients Albumin to Fibrinogen Biomarker Postoperative delirium |