What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Delirium-associated medication in people at risk: A systematic update review, meta-analyses, and GRADE-profiles
- Authors
- Reisinger, M. Reininghaus, E. Z. Biasi, J. Fellendorf, F. T. Schoberer, D.
- Year
- 2023
- Journal
- Acta Psychiatr Scand
- Abstract
BACKGROUND: Drug-associated delirium is a common but potentially preventable neuropsychiatric syndrome associated with detrimental outcomes. Empirical evidence for delirium-associated medication is uncertain due to a lack of high-quality studies. We aimed to further investigate the body of evidence for drugs suspected to trigger delirium. METHODS: A systematic update review and meta-analyses of prospective studies presenting drug associations with incident delirium in adult study populations was conducted. Two authors independently searched MEDLINE, PsycINFO, Embase, and Google Scholar dated from October 1, 2009 to June 23, 2020, after screening a previous review published in 2011. The most reliable results on drug-delirium associations were pooled in meta-analyses using the random-effects model. Quality of evidence was assessed using the GRADE-approach. This study is preregistered with OSF (DOI https://doi.org.10.17605/OSF.IO/4PUHY). RESULTS: The 31 eligible studies, presenting results for 24 medication classes were identified. Meta-analyses and GRADE level of evidence ratings show no increased delirium risk for Haloperidol (OR: 0.96, 95% CI 0.72-1.28; high-quality evidence), Olanzapine (OR: 0.25, 95% CI 0.15-0.40), Ketamine (OR: 0.72, 95% CI 0.35-1.46) or corticosteroids (OR: 0.69, 95% CI 0.32-1.50; moderate quality evidence, respectively). Low-level evidence suggests a three-fold increased risk for anticholinergics (OR: 3.11, 95% CI 1.04-9.26). Opioids, benzodiazepines, H(1) -antihistamines, and antidepressants did not reach reliable evidence levels in our analyses. CONCLUSION: We investigated the retrievable body of evidence for delirium-associated medication. The results of this systematic review were then interpreted in conjunction with other evidence-based works and guidelines providing conclusions for clinical decision-making.
- PMID
- Keywords
Adult
Humans
Prospective Studies
*Haloperidol/adverse effects
*Delirium/chemically induced/epidemiology/drug therapy
deliriogenic
delirium
drug associated delirium
medication
meta-analysis
systematic review
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Effect of oxygen delivery during cardiopulmonary bypass on postoperative neurological outcomes in patients undergoing cardiac surgery: A scoping review of the literature | Elsebaie, A. Shakeel, A. Zhang, S. Alarie, M. El Tahan, M. El-Diasty, M. | Perfusion | 2025 |
Humans *Cardiopulmonary Bypass/methods/adverse effects *Cardiac Surgical Procedures/adverse effects/methods *Oxygen/blood Postoperative Complications/etiology/prevention & control Nervous System Diseases/etiology/prevention & control cardiac surgery cardiopulmonary bypass cognitive dysfunction delirium oxygen delivery postoperative neurological complications stroke |
| Anesthesia-induced electroencephalogram oscillations and perioperative outcomes in older adults undergoing cardiac surgery | Freedman, I. G. Boncompte, G. Qu, J. Z. Khawaja, Z. Q. Turco, I. Mueller, A. Wiredu, K. McKay, T. B. Westover, M. B. Pedemonte, J. C. Akeju, O. | J Clin Anesth | 2025 |
Humans Female Aged Male *Anesthesia, General/adverse effects *Electroencephalography/drug effects *Cardiac Surgical Procedures/adverse effects Middle Aged *Dexmedetomidine/adverse effects/administration & dosage Emergence Delirium/epidemiology/diagnosis/prevention & control Patient Readmission/statistics & numerical data Postoperative Complications/epidemiology/etiology/diagnosis Isoflurane/adverse effects/administration & dosage Anesthetics, Inhalation/adverse effects/administration & dosage Cardiopulmonary Bypass/adverse effects Aged, 80 and over Incidence Elective cardiac surgery Intraoperative alpha power Intraoperative electroencephalogram Perioperative outcomes Postoperative delirium |
| Prevention and management of postoperative delirium in adult patients: a best practice implementation project | Gnatta, J. R. Paes, S. O. G. Faria, M. F. O. Cicarelli, D. D. Laurino, R. V. S. Hamano, L. Püschel, V. A. A. Poveda, V. B. | Rev Esc Enferm USP | 2025 |
Humans *Postoperative Complications/prevention & control *Delirium/prevention & control Practice Guidelines as Topic Adult Guideline Adherence Evidence-Based Practice |
| Prediction model for delirium in advanced cancer patients receiving palliative care: development and validation | Guo, D. Zhang, C. Leng, C. Fan, Y. Wang, Y. Chen, L. Zhang, H. Ge, N. Yue, J. | BMC Palliat Care | 2025 |
Humans *Delirium/etiology *Palliative Care/methods/standards Female Male Middle Aged *Neoplasms/complications Prospective Studies Aged China/epidemiology Nomograms Logistic Models Aged, 80 and over Adult Risk Factors ROC Curve Delirium Neoplasms Nomogram Palliative care |
| Videodistraction to reduce agitation in elderly patients in the emergency department: an open label parallel group randomized controlled trial | Güvec, E. Koedel, U. Horster, S. Pedersen, V. Völk, S. Waldow, M. Weber, F. Klein, M. | Eur J Emerg Med | 2025 |
Humans *Psychomotor Agitation *Emergency Service, Hospital Aged Male Female Prospective Studies Aged, 80 and over Delirium/prevention & control/diagnosis Video Recording Geriatric Assessment/methods |
| Comprehensive Geriatric Assessment, Treatment Decisions, and Outcomes in Older Patients Eligible for Pancreatic Surgery | Hartog, M. Beishuizen, S. J. E. Togo, R. van Bruchem-Visser, R. L. van Eijck, C. H. J. Mattace-Raso, F. U. S. Pek, C. J. de Wilde, R. F. Groot Koerkamp, B. Polinder-Bos, H. A. | J Surg Oncol | 2024 |
Humans Aged Male Female *Pancreatic Neoplasms/surgery/mortality/pathology Prospective Studies *Geriatric Assessment Aged, 80 and over *Postoperative Complications/epidemiology Frailty/complications Pancreatectomy/mortality Pancreaticoduodenectomy/adverse effects/mortality Frail Elderly Clinical Decision-Making Follow-Up Studies Prognosis Survival Rate elderly frailty functional decline geriatric oncology pancreatic cancer pancreatic surgery periampullary cancer |
| Pharmacological Strategies for Providing Patients With Delirium Relief From Terminal Dyspnea: A Secondary Data Analysis | Hasegawa, T. Mori, M. Yamaguchi, T. Imai, K. Matsuda, Y. Maeda, I. Hatano, Y. Yokomichi, N. Hamano, J. Morita, T. | Cancer Med | 2025 |
Humans *Delirium/drug therapy *Dyspnea/drug therapy/etiology Male Female Aged *Antipsychotic Agents/therapeutic use *Analgesics, Opioid/therapeutic use *Palliative Care/methods Middle Aged Prospective Studies Aged, 80 and over Neoplasms/complications/drug therapy Japan Terminal Care/methods Treatment Outcome Secondary Data Analysis antipsychotic agents delirium dyspnea neoplasm opioid palliative care |
| Associations of Frailty Status and Sleep Quality With Incident Delirium: A Prospective Study in the UK Biobank | Huang, Y. Chen, G. Ma, N. Wang, L. Wang, Y. Jia, Z. Huang, M. He, D. | CNS Neurosci Ther | 2025 |
Humans Female Male *Delirium/epidemiology United Kingdom/epidemiology *Frailty/epidemiology/complications Aged *Sleep Quality Middle Aged Prospective Studies *Biological Specimen Banks Incidence Risk Factors Sleep Wake Disorders/epidemiology Aged, 80 and over Follow-Up Studies Adult UK Biobank delirium incidence frailty interaction prospective study sleep quality |
| Intra- and early postoperative predictors of delirium risk in cardiac surgery: results from the prospective observational FINDERI study | Itting, P. T. Sadlonova, M. Santander, M. J. Knierim, M. Derad, C. Asendorf, T. Celano, C. M. Hansen, N. Esselmann, H. Heinemann, S. Eberhard, C. Hoteit, M. Schröder, M. F. Kutschka, I. Wiltfang, J. von Arnim, C. A. F. Baraki, H. | Int J Surg | 2025 |
Postoperative delirium, cardiac surgery, early postoperative factors, CAM, machine learning |
| Inpatient Use of Valproic Acid in Agitated Delirium by Palliative Medicine | Jacobs, S. Herbst, L. Fernandez, C. Mehta, Z. Y. Young, A. Davis, M. P. | Am J Hosp Palliat Care | 2025 |
agitated delirium antipsychotic and benzodiazepine sparing therapy delirium hospital care valproate valproic acid |
| Preventative interventions for postoperative delirium after intraabdominal surgery - A systematic review and meta-analysis of randomized trials | Jensen, J. Thorhauge, K. Petri, C. L. Madsen, M. T. Burcharth, J. | Am J Surg | 2025 |
Intra-abdominal Meta-analysis Postoperative delirium Preventive interventions Surgery Systematic review |
| Patients' and family members' dyadic experience of post-operative delirium in the intensive care unit: A qualitative study | Jing, D. Weijing, S. Yiyu, Z. | Nurs Crit Care | 2025 |
Humans *Qualitative Research Male Female *Intensive Care Units *Family/psychology *Delirium/psychology *Postoperative Complications/psychology Middle Aged Aged Interviews as Topic Adult critical care patient‐ and family‐centred care post‐operative delirium qualitative research |
| Use of Oral Celecoxib Preoperatively Reduces Risk of Delirium and Favors Functional Recovery in Elderly Patients with Femoral Neck Fracture: A Propensity Score-Matched Analysis | Ju, M. Han, X. He, L. Jiang, J. Wang, M. Lin, W. Liu, Y. | J Pain Res | 2025 |
celecoxib delirium elderly femoral neck fracture pain |
| Perioperative Near Infrared Spectroscopy Measurements of Cerebral Regional Oxygen Desaturations Are Not Associated With Delirium After Cardiac Surgery | Kahn, R. A. Egorova, N. Ouyang, Y. Huang, J. Levin, M. A. Hofer, I. Anyanwu, A. Weiner, M. M. | J Cardiothorac Vasc Anesth | 2025 |
cardiac surgery delirium near-infrared spectroscopy postoperative outcome regional cerebral oximetry |
| Melatonin for preventing postoperative delirium in elderly patients: A multicenter randomized placebo-controlled pilot study | Khaled, M. Chui, J. Ewusie, J. Agzarian, J. Bogach, J. Gomez, M. Shayegan, B. Shargall, Y. Alkhamesi, N. Paul, J. Thabane, L. Shanthanna, H. | Medicine (Baltimore) | 2025 |
Humans *Melatonin/therapeutic use/administration & dosage Aged Male Female Pilot Projects *Postoperative Complications/prevention & control/epidemiology *Delirium/prevention & control/epidemiology/etiology Feasibility Studies Aged, 80 and over Incidence Double-Blind Method Sleep Quality Medication Adherence |
| The Effects of Remimazolam and Inhalational Anesthetics on the Incidence of Postoperative Hyperactive Delirium in Geriatric Patients Undergoing Hip or Femur Surgery Under General Anesthesia: A Retrospective Observational Study | Kim, J. Lee, S. Yoo, B. H. Lim, Y. H. Jun, I. J. | Medicina (Kaunas) | 2025 |
Humans Male Female Aged Retrospective Studies Incidence *Anesthetics, Inhalation/adverse effects *Benzodiazepines/therapeutic use/adverse effects Aged, 80 and over *Anesthesia, General/adverse effects *Postoperative Complications/epidemiology Femur/surgery Delirium/epidemiology Sevoflurane/adverse effects Hip/surgery Emergence Delirium/epidemiology Propensity Score Logistic Models hip surgery postoperative delirium remimazolam sevoflurane |
| The Role of Cytokines in Perioperative Neurocognitive Disorders: A Review in the Context of Anesthetic Care | Koh, H. J. Joo, J. | Biomedicines | 2025 |
anesthesia blood–brain barrier cytokine neuroinflammation perioperative neurocognitive disorder postoperative cognitive dysfunction postoperative delirium |
| Evaluation of the Quality of Delirium Website Content for Patient and Family Education: Cross-Sectional Study | Krewulak, K. Strayer, K. Jaworska, N. Spence, K. Foster, N. Kupsch, S. Sauro, K. Fiest, K. M. | J Med Internet Res | 2025 |
Humans *Delirium *Internet Cross-Sectional Studies *Family Patient Education as Topic/standards/methods accessibility brain lesions caregiver confusion delirium disorientation education family education health information high-quality websites inattentiveness information seeking internet patient readability |
| Subcutaneous dexmedetomidine for sedation of agitated delirium in palliative care | Lapenskie, J. Downar, J. Wolfe, A. Polskaia, N. van den Berg, K. Watt, C. Bush, S. H. Boese, K. Barnes, C. J. Parsons, H. A. Kanji, S. Heidinger, B. Lawlor, P. G. | Ann Palliat Med | 2025 |
Humans *Dexmedetomidine/administration & dosage/therapeutic use *Delirium/drug therapy Female Male *Palliative Care/methods Prospective Studies Aged *Hypnotics and Sedatives/therapeutic use/administration & dosage Middle Aged Aged, 80 and over *Psychomotor Agitation/drug therapy Adult Infusions, Subcutaneous Delirium dexmedetomidine palliative care prospective study sedation |
| Association of polypharmacy and perioperative outcomes: Systematic review and meta-analysis | Lee, Y. Liew, Y. Sim, M. H. Sim, X. L. J. | J Perioper Pract | 2025 |
Perioperative outcomes Polypharmacy Postoperative delirium Systematic review |
| Pilot implementation of an electronic diagnostic support tool (AiD-DST) designed to identify the cause(s) of delirium | Leong, E. Chang, S. Yearwood, K. Eeles, E. Yerkovich, S. Ling, C. Teodorczuk, A. Dissanayaka, N. | Australas J Ageing | 2025 |
Humans *Delirium/diagnosis Pilot Projects *Predictive Value of Tests Female Male Decision Support Systems, Clinical Decision Support Techniques Diagnosis, Computer-Assisted Aged delirium digital technology point‐of‐care diagnostics |
| Effect of preoperative oral carbohydrate on postoperative delirium in elderly patients undergoing lower extremity orthopedic surgery: a prospective randomized trial | Li, L. T. Wang, X. H. Zuo, Y. B. He, Y. H. Lin, J. Chen, H. X. Huang, Y. | J Orthop Surg Res | 2025 |
Humans Male Aged Female *Orthopedic Procedures/adverse effects Prospective Studies *Preoperative Care/methods *Postoperative Complications/prevention & control/etiology *Lower Extremity/surgery Incidence Dietary Carbohydrates/administration & dosage C-Reactive Protein/metabolism/analysis Delirium/prevention & control/etiology/epidemiology Blood Glucose/metabolism Interleukin-6/blood Aged, 80 and over Administration, Oral Middle Aged Carbohydrate Older patients Orthopedic surgery Postoperative delirium |
| The triglyceride glucose index and delirium risk in sepsis patients: A causal inference study | Li, X. Yang, J. Tang, Y. Liang, X. Bai, Z. Cheng, H. Wang, Y. Lyu, J. | Nurs Crit Care | 2025 |
Humans *Sepsis/blood *Delirium/epidemiology/blood/etiology/diagnosis Male Female *Triglycerides/blood Middle Aged *Intensive Care Units/statistics & numerical data *Blood Glucose/analysis Risk Factors Aged Incidence Propensity Score causal inference delirium intensive care unit sepsis triglyceride glucose index |
| Intra-operative blood transfusions raise the risk of postoperative delirium and impede functional recovery in elderly hip fracture patients: a propensity score-matched study | Li, Y. Wang, T. Zhang, J. Wang, Z. Guo, J. Zhang, Q. | J Orthop Traumatol | 2025 |
Humans *Hip Fractures/surgery *Propensity Score Female Male Aged Retrospective Studies Aged, 80 and over *Postoperative Complications/epidemiology *Delirium/etiology/epidemiology *Recovery of Function *Length of Stay/statistics & numerical data *Fracture Fixation, Intramedullary/adverse effects/methods Blood Transfusion/statistics & numerical data Risk Factors Incidence Intraoperative Care/methods Blood transfusion Elderly Intertrochanteric fractures Postoperative delirium Postoperative outcome Propensity score matching Retrospective study |
| Geriatric traumatology-Principles of orthogeriatrics | Liener, U. C. Neuerburg, C. Hoffmann, R. Bökeler, U. | Chirurgie (Heidelb) | 2025 |
Humans Aged *Geriatrics *Osteoporotic Fractures/surgery/therapy *Traumatology Aged, 80 and over Female Intersectoral Collaboration Germany Male Complications Delirium Fragility fractures Multimorbidity Osteoporosis |
| Evaluating Midazolam's Influence on Bispectral Index and Propofol Concentrations Using Schnider and Eleveld Models in Target-Controlled Infusion General Anesthesia: A Prospective Observational Study | Linassi, F. Zanatta, P. Kreuzer, M. Ciavattini, E. Rizzetto, C. Carron, M. | Life (Basel) | 2025 |
adverse effects anxiolytics bispectral index monitor elderly infusion pump intravenous anesthesia midazolam propofol |
| Clinical biomarkers of perioperative neurocognitive disorder: initiation and recommendation | Liu, J. Li, C. Yao, J. Zhang, L. Zhao, X. Lv, X. Liu, Z. Miao, C. Wang, Y. Jiang, H. Yu, W. Wang, T. Wang, D. Wang, E. Gu, X. Dong, H. Cao, J. Shen, Y. Song, W. Chen, S. Wang, Y. Liu, G. Xie, Z. Xiong, L. Zheng, J. C. | Sci China Life Sci | 2025 |
biomaker clinical biomarkers perioperative neurocognitive disorders postoperative cognitive dysfunction postoperative delirium |
| Characteristics and risk factors of delirium in patients on veno-arterial extracorporeal membrane oxygenation | Liu, O. Sun, P. Y. Ahmad, S. A. Kalra, A. Feng, A. Whitman, G. J. R. Kim, B. S. Cho, S. M. | Perfusion | 2025 |
delirium veno-arterial ECMO |
| The effect of delirium on the association between frailty and postoperative major complications in elderly patients: a mediation analysis | Liu, Y. F. Cui, F. Su, X. Li, Y. W. Zhang, Y. Li, C. J. Mu, D. L. Wang, D. X. | J Anesth | 2025 |
Elder patients Frailty Mediation analysis Postoperative complications Postoperative delirium |
| A bibliometric analysis on delirium in intensive care unit from 2013-2023 | Ma, X. Wu, Q. Ran, Y. Cao, X. Zheng, H. | Front Neurol | 2025 |
Citespace Icu VOSviewer delirium intensive care unit |
| The effects of structured family auditory stimulation on preventing ICU delirium among patients with unplanned admissions: A randomized controlled study | Ma, Y. Zhang, Y. Cui, N. Guo, Z. Jin, J. | Intensive Crit Care Nurs | 2025 |
Auditory stimulation Critical care Delirium Family-centred care Intensive care unit |
| Effect of combination of multiple anti-inflammatory drugs strategy on postoperative delirium among older patients undergoing hip fracture surgery: a pilot randomized controlled trial | Nawan, A. Wu, Z. Jiang, B. Wang, G. Zhang, W. Feng, Y. | BMC Med | 2025 |
Humans *Hip Fractures/surgery Female Male Pilot Projects Aged, 80 and over Aged Double-Blind Method *Delirium/prevention & control *Postoperative Complications/prevention & control *Anti-Inflammatory Agents/administration & dosage/therapeutic use Dexmedetomidine/administration & dosage/therapeutic use Drug Therapy, Combination Anti-Inflammatory Agents, Non-Steroidal/therapeutic use/administration & dosage Glucocorticoids/administration & dosage/therapeutic use Glycoproteins Anti-inflammatory Hip fracture Perioperative management Pharmacological interventions Postoperative delirium |
| Linear association between high-sensitivity C-reactive protein and postoperative delirium after general anesthesia: a cross-sectional study | Qin, X. Ren, J. Xing, C. Chen, L. Wang, R. Tian, S. | Front Neurol | 2025 |
general anesthesia high-sensitivity C-reactive protein inflammation postoperative delirium restricted cubic spline |
| Characterization of Speech and Language Deficits in the Postanesthesia Care Unit: A Novel, Qualitative Cognitive Assessment | Ahmed, M. T. Troyas, C. Daramola, A. M. Isik, O. G. Cassim, T. Z. Goldberg, T. E. Banerji, A. Sleigh, J. García, P. S. | Anesth Analg | 2025 |
Humans Female Male Middle Aged Aged *Anesthesia Recovery Period *Cognition *Anesthesia, General Adult Speech Disorders/diagnosis/etiology/psychology Language Disorders/diagnosis/etiology/psychology Mental Status and Dementia Tests Speech Neuropsychological Tests |
| The Relationship Between the Average Infusion Rate of Propofol and the Incidence of Delirium During Invasive Mechanical Ventilation: A Retrospective Study Based on the MIMIC IV Database | Ge, Q. Y. Zheng, C. Song, X. B. Cong, Z. Z. Luo, J. Zheng, H. T. Zhao, P. L. Wang, Y. Q. Chen, B. W. Shen, Y. | CNS Neurosci Ther | 2025 |
Humans *Propofol/adverse effects/administration & dosage Male *Delirium/epidemiology/chemically induced Female *Respiration, Artificial/adverse effects Retrospective Studies Middle Aged Incidence Aged *Databases, Factual/trends *Hypnotics and Sedatives/adverse effects/administration & dosage Infusions, Intravenous Adult Anesthetics, Intravenous/adverse effects/administration & dosage Aged, 80 and over delirium invasive mechanical ventilation odds ratio propofol |
| Safety and effectiveness of inhaled sedation in critically ill patients: a systematic review and meta-analysis | Feng, F. Kang, H. Yang, Z. Ma, L. Chen, Y. | Syst Rev | 2025 |
Humans *Critical Illness/therapy *Hypnotics and Sedatives/administration & dosage/adverse effects Anesthetics, Inhalation/administration & dosage/adverse effects Intensive Care Units Length of Stay Administration, Inhalation Airway Extubation Postoperative Nausea and Vomiting Critically ill patients Delirium Inhaled sedation Intravenous sedation Sevoflurane |
| Exploring Cognitive Stimulation as a Therapy for the Prevention of Delirium in a Hospital Setting: A Narrative Review | Fatima, E. Hill, I. Dover, N. Faisal, H. | Behav Sci (Basel) | 2025 |
cognitive prehabilitation cognitive rehabilitation cognitive stimulation cognitive training delirium geriatric prevention |
| Development and validation of a nomogram for predicting model for delirium after stroke | Cui, C. Han, G. Wang, Y. Zhao, B. Li, Q. | Asian Nurs Res (Korean Soc Nurs Sci) | 2025 |
delirium nomograms risk factors stroke |
| Efficacy of Cerebral Oxygen Saturation Monitoring for Perioperative Neurocognitive Disorder in Adult Noncardiac Surgical Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Qiu, L. Ma, Y. Ge, L. Zhou, H. Jia, W. | World Neurosurg | 2025 |
Humans *Randomized Controlled Trials as Topic/methods *Oxygen Saturation/physiology Postoperative Cognitive Complications/prevention & control Neurocognitive Disorders/diagnosis/etiology/prevention & control Monitoring, Intraoperative/methods Postoperative Complications/prevention & control Spectroscopy, Near-Infrared/methods Brain/metabolism Anesthesia, General/methods Elective Surgical Procedures/adverse effects Adult Near-infrared spectroscopy Perioperative neurocognitive disorders Postoperative cognitive decline Postoperative cognitive dysfunction Postoperative delirium Regional cerebral oxygen saturation |
| The relationship between stress hyperglycemia ratio and the risk of delirium in patients after coronary artery bypass grafting | Shen, H. Zhang, P. | Eur J Med Res | 2025 |
Humans *Coronary Artery Bypass/adverse effects Male Female Aged *Delirium/etiology/blood/epidemiology *Hyperglycemia/etiology/blood/complications *Postoperative Complications/etiology/blood/epidemiology Middle Aged Risk Factors Blood Glucose/analysis/metabolism Coronary artery bypass grafting Glycated hemoglobin Postoperative delirium Stress hyperglycemia |
| Jugular Venous Oxygen and Lactate Parameters for Predicting Early Cognitive Dysfunction after Off-Pump Coronary Artery Bypass Grafting: A Prospective Observational Study | Singh, P. Anchukandan, R. A. Karna, S. T. Niwariya, Y. Waindeskar, V. Kumar, H. Padala, S. B. Kiran, M. | Ann Indian Acad Neurol | 2025 |
Postoperative Cognitive Dysfunction Off-pump coronary artery bypass Postoperative Delirium Jugular venous lactate Oxygen |
| Statins Reduce Delirium Risk in Older Adults With Type 2 Diabetes | Sun, M. Wang, X. Lu, Z. Yang, Y. Lv, S. Miao, M. Chen, W. M. Wu, S. Y. Zhang, J. | J Am Med Dir Assoc | 2025 |
Statins delirium dose-dependent relationship elderly type 2 diabetes mellitus |
| Enhancing Accurate Delirium Detection in Older Patients With Heart Failure: Integrating Education and an Electronic Health Record Tool for Nurses | Tabarani, E. Hickey, K. Blush, R. R., 3rd | J Dr Nurs Pract | 2025 |
baseline cognition delirium electronic health record tools geriatrics nurse education nursing informatics |
| Brain Pro-TCT: a prospective, quasi-experimental study on early delirium detection with Delirium Observation Screening Scale versus single-channel EEG after cardiac surgery in patients aged over 70 years | Ten Broeke, M. Henckens, W. P. R. Weierink, A. Speekenbrink, R. G. H. van der Palen, J. Halfwerk, F. R. | Eur J Cardiovasc Nurs | 2025 |
delirium delta rhythm elderly electroencephalography thoracic surgery |
| The effectiveness of family participation interventions for the prevention of delirium in intensive care units: A systematic review | Vitorino, M. L. Henriques, A. Melo, G. Henriques, H. R. | Intensive Crit Care Nurs | 2025 |
Critical Care Critical Care Nursing Delirium Family Intensive Care Units |
| Comparison of programmed sedation care with conventional care in patients receiving mechanical ventilation for acute respiratory failure | Wang, J. Li, Y. Han, Y. Yuan, X. | Ir J Med Sci | 2025 |
Humans *Respiration, Artificial/methods/statistics & numerical data Male Female Middle Aged *Hypnotics and Sedatives/therapeutic use/administration & dosage *Respiratory Insufficiency/therapy/etiology Aged Adult Length of Stay/statistics & numerical data Acute Disease Acute respiratory failure Delirium Intensive care Mechanical ventilation Programmed sedation care |
| Effectiveness of perioperative remimazolam in preventing postoperative delirium: a systematic review and meta-analysis | Wang, M. Liu, J. Liu, W. Zhang, X. Zhang, G. Sun, L. Bi, Y. Wang, H. Dong, R. | Eur J Med Res | 2025 |
Humans *Benzodiazepines/adverse effects/therapeutic use/administration & dosage Hypnotics and Sedatives/administration & dosage/adverse effects/therapeutic use Postoperative Complications/prevention & control Perioperative Care/methods Dexmedetomidine/therapeutic use/administration & dosage Emergence Delirium/prevention & control/epidemiology Hypotension/prevention & control/chemically induced Delirium/prevention & control Randomized Controlled Trials as Topic General anesthesia Meta-analysis Postoperative delirium Remimazolam Safety |
| Medication-induced causes of delirium in patients with and without dementia: a systematic review of published neurology guidelines | Weidmann, A. E. Proppé, G. B. Matthíasdóttir, R. Tadić, I. Gunnarsson, P. S. Jónsdóttir, F. | Int J Clin Pharm | 2025 |
Clinical guidelines as topic Delirium Dementia Medication therapy management Neurology |
| Incidence and influencing factors of subsyndromal delirium in elderly patients with pancreatic surgery: a prospective study | Xu, H. Q. Wang, Y. Xia, N. N. Pan, K. C. | Front Psychiatry | 2025 |
elderly pancreas postoperative risk factors subsyndromal delirium |
| Intranasal Insulin Diminishes Postoperative Delirium and Elevated Osteocalcin and Brain Derived Neurotrophic Factor in Older Patients Undergoing Joint Replacement: A Randomized, Double-Blind, Placebo-Controlled Trial | Yang, M. Zhou, L. Long, G. Liu, X. Ouyang, W. Xie, C. He, X. | Drug Des Devel Ther | 2025 |
Humans Double-Blind Method Aged *Administration, Intranasal Male Female *Brain-Derived Neurotrophic Factor *Insulin/administration & dosage *Delirium/prevention & control/drug therapy *Osteocalcin/blood Insulin Resistance Biomarkers/blood Postoperative Complications/prevention & control/drug therapy Arthroplasty, Replacement/adverse effects Aged, 80 and over brain derived neurotrophic factor intranasal insulin older patient osteocalcin postoperative delirium |
| Effects of remimazolam and propofol on sleep rhythm and delirium after spinal surgery in elderly patients | Yaqiu, L. Heng, Z. Ruimin, W. Xuri, W. | Perioper Med (Lond) | 2025 |
Cortisol Melatonin Postoperative delirium Remimazolam Sleep rhythm Spinal surgery |
| Association between periprocedural cerebral desaturation during transcatheter aortic valve implantation and postprocedural delirium: a prospective observational study | Yilmaz Ak, H. Sandal, B. Ozsahin, Y. Salihoglu, Z. Yildiz, A. Erturk Tekin, E. Yesiltas, M. A. Yildiz, M. Erkalp, K. | BMC Anesthesiol | 2025 |
Humans *Transcatheter Aortic Valve Replacement/adverse effects/methods Female Prospective Studies Aged Male Aged, 80 and over *Spectroscopy, Near-Infrared/methods *Delirium/etiology Middle Aged Postoperative Complications Oxygen Saturation/physiology Near-Infrared spectroscopy Postoperative delirium Transcatheter aortic valve implantation |
| Effect of dexmedetomidine on postoperative delirium in patients undergoing type A aortic dissection surgery: a prospective cohort study | Yu, Y. R. Wang, Y. L. Zhu, X. W. Li, L. Wang, D. J. Wang, Y. P. Ye, J. X. | J Thorac Dis | 2025 |
Dexmedetomidine aortic dissection cardiac surgery postoperative delirium (POD) |
| Haloperidol for the treatment of delirium in ICU patients: a systematic review and meta‑analysis | Zhao, Y. Wang, Q. Sun, B. Li, Y. Meng, C. Miao, G. | Eur J Med Res | 2025 |
Humans *Haloperidol/therapeutic use *Delirium/drug therapy *Intensive Care Units Antipsychotic Agents/therapeutic use Length of Stay Randomized Controlled Trials as Topic Delirium Efficacy Haloperidol Icu |
| Frailty as an independent risk factor for sepsis-associated delirium: a cohort study of 11,740 older adult ICU patients | Zheng, G. Yan, J. Li, W. Chen, Z. | Aging Clin Exp Res | 2025 |
Humans Aged Male Female *Intensive Care Units *Delirium/epidemiology/etiology Aged, 80 and over *Sepsis/complications/epidemiology Risk Factors *Frailty/complications/epidemiology Retrospective Studies Frail Elderly Cohort Studies Frailty Intensive care unit Older adults Sepsis Sepsis-associated delirium |
| Functional MRI-based machine learning strategy for prediction of postoperative delirium in cardiac surgery patients: A secondary analysis of a prospective observational study | Zhou, M. Y. Shi, Y. B. Bai, S. J. Lu, Y. Zhang, Y. Zhang, W. Wang, W. Zhu, Y. Z. Cao, J. L. Wang, L. W. | J Clin Anesth | 2025 |
Humans Prospective Studies Female Male Middle Aged *Magnetic Resonance Imaging *Machine Learning *Cardiac Surgical Procedures/adverse effects Aged *Delirium/diagnosis/etiology *Postoperative Complications/diagnosis/etiology/diagnostic imaging Predictive Value of Tests Heart Valve Prosthesis Implantation/adverse effects China Brain/diagnostic imaging Cardiac surgery Functional magnetic resonance imaging Machine learning Postoperative delirium Prediction model |
| Novel drug targets for delirium based on genetic causality | Zhu, S. Ding, X. Bo, J. Xia, T. Gu, X. | J Affect Disord | 2025 |
Colocalization analysis Drug targets Druggable genome Mendelian randomization cis-eQTL |
| The Implementation of Perioperative Geriatric Management Could Decrease the Incidence of Postoperative Delirium in the Elderly Undergoing Major Orthopedic Surgeries | Zou, Y. Deng, T. Xu, Y. Zheng, Q. Wu, Y. Hui, S. Liu, C. Wei, A. | J Patient Saf | 2025 |
Humans Aged Male Female *Orthopedic Procedures/adverse effects *Delirium/prevention & control/epidemiology Aged, 80 and over *Postoperative Complications/prevention & control/epidemiology Incidence *Perioperative Care/methods Geriatric Assessment/methods |
| Development and Validation of a Routine Electronic Health Record-Based Delirium Prediction Model for Surgical Patients Without Dementia: Retrospective Case-Control Study | Holler, E. Ludema, C. Ben Miled, Z. Rosenberg, M. Kalbaugh, C. Boustani, M. Mohanty, S. | JMIR Perioper Med | 2025 |
Humans *Electronic Health Records/statistics & numerical data Female Male Aged Retrospective Studies *Delirium/diagnosis/epidemiology/etiology Case-Control Studies Middle Aged *Postoperative Complications/epidemiology/diagnosis/etiology Dementia/epidemiology/diagnosis Risk Assessment/methods Indiana/epidemiology Aged, 80 and over Machine Learning Predictive Value of Tests algorithm delirium electronic health records postoperative prediction risk prediction surgery |
| Multivariable Predictive Model of Postoperative Delirium in Cardiac Surgery Patients: Proteomic and Demographic Contributions | Gonçalves, M. C. B. Khera, T. Otu, H. H. Narayanan, S. Dillon, S. T. Shanker, A. Gu, X. Jung, Y. Ngo, L. H. Marcantonio, E. R. Libermann, T. A. Subramaniam, B. | Anesth Analg | 2025 |
Humans Male Female Aged *Cardiac Surgical Procedures/adverse effects *Proteomics/methods *Biomarkers/blood *Predictive Value of Tests Risk Factors Delirium/blood/diagnosis/etiology Middle Aged Multivariate Analysis Risk Assessment Aged, 80 and over Postoperative Complications/diagnosis/blood/etiology Prospective Studies |
| Outcomes of a delirium prevention program after major abdominal emergency surgery: An interventional study | Finne, K. F. Thorup, T. Skovsen, A. P. G. Tolstrup, M. B. | World J Surg | 2025 |
Humans Male Female Aged *Delirium/prevention & control/etiology *Postoperative Complications/prevention & control/epidemiology Aged, 80 and over Length of Stay/statistics & numerical data Treatment Outcome Emergencies Abdomen/surgery emergency surgery major abdominal surgery postoperative delirium |
| Incidence and risk factors of postoperative delirium in elderly surgical patients 2023 | Fenta, E. Teshome, D. Kibret, S. Hunie, M. Tiruneh, A. Belete, A. Molla, A. Dessie, B. Geta, K. | Sci Rep | 2025 |
Aged Aged, 80 and over Female Humans Male Middle Aged Delirium/epidemiology/etiology *Emergence Delirium/epidemiology/etiology Ethiopia/epidemiology Incidence *Postoperative Complications/epidemiology/etiology Prevalence Risk Factors Elderly patients Nursing delirium screening scale Post anesthesia care unit Postoperative delirium |
| Association Between Blood Urea Nitrogen and Delirium in Critically Ill Elderly Patients Without Kidney Diseases: A Retrospective Study and Mendelian Randomization Analysis | Fang, Y. Tang, X. Gao, Y. Xie, H. Shen, Y. Peng, M. Liu, J. Zhang, Y. Cui, Y. Xie, K. | CNS Neurosci Ther | 2025 |
Humans *Mendelian Randomization Analysis *Critical Illness Retrospective Studies Aged *Delirium/blood/epidemiology/genetics/diagnosis Male Female *Blood Urea Nitrogen Aged, 80 and over Risk Factors Icu‐cam Mimic iv delirium elderly encephalopathy mendelian randomization urea nitrogen |
| Machine Learning-Based Prediction of Delirium and Risk Factor Identification in ICU Patients with Burns: A Retrospective Observational Study | Esumi, R. Funao, H. Kawamoto, E. Sakamoto, R. Ito-Masui, A. Okuno, F. Shinkai, T. Hane, A. Ikejiri, K. Akama, Y. Gaowa, A. Park, E. J. Momosaki, R. Kaku, R. Shimaoka, M. | JMIR Form Res | 2025 |
Delirium, ICU, Burn care, Machine learning model, ICU delirium screening checklist |
| Influence of Intraoperative Pain Management on Postoperative Delirium in Elderly Patients: A Prospective Single-Center Randomized Controlled Trial | Du, Y. Cao, J. Gao, C. He, K. Wang, S. | Pain Ther | 2025 |
Analgesia pain Geriatric anesthesia Pain management Postoperative delirium |
| Prevalence of delirium in German nursing homes: protocol for a cross-sectional study | Dörner, J. Houdelet-Oertel, A. Arslan, Z. Lauer, R. Otte, I. Vollmar, H. C. Thürmann, P. Palm, R. Holle, B. | BMJ Open | 2025 |
Humans *Nursing Homes/statistics & numerical data Germany/epidemiology Cross-Sectional Studies Prevalence *Delirium/epidemiology/diagnosis Aged Male Homes for the Aged/statistics & numerical data Female Research Design Aged, 80 and over Delirium & cognitive disorders Epidemiologic studies Geriatric medicine |
| Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium | Denver, P. Tortorelli, L. Hov, K. Berg, J. P. Giil, L. M. Nazmi, A. Lopez-Rodriguez, A. Healy, D. Murray, C. Barry, R. Watne, L. O. Cunningham, C. | Brain Behav Immun Health | 2025 |
Blood CSF barrier Blood brain barrier Ccl11 Csf Chemokines Delirium Mip1α Systemic inflammation |
| Delirium at the intensive care unit and long-term survival: a retrospective study | De Trizio, I. Komninou, M. A. Ernst, J. Schüpbach, R. Bartussek, J. Brandi, G. | BMC Neurol | 2025 |
Humans Retrospective Studies *Intensive Care Units/statistics & numerical data Middle Aged *Delirium/mortality/epidemiology/diagnosis Male Female Aged Switzerland/epidemiology Adult Survivors/statistics & numerical data Delirium Encephalopathy Icu Long-term survival |
| Dose-response analysis of music intervention for improving delirium in intensive care unit patients: A systematic review and meta-analysis | Dai, R. S. Wang, T. H. Chien, S. Y. Tzeng, Y. L. | Nurs Crit Care | 2025 |
delirium dose–response analysis intensive care unit (ICU) music therapy |
| Dose-response analysis of music intervention for improving delirium in intensive care unit patients: A systematic review and meta-analysis | Dai, R. S. Wang, T. H. Chien, S. Y. Tzeng, Y. L. | Nurs Crit Care | 2025 |
delirium dose–response analysis intensive care unit (ICU) music therapy |
| Dose-response analysis of music intervention for improving delirium in intensive care unit patients: A systematic review and meta-analysis | Dai, R. S. Wang, T. H. Chien, S. Y. Tzeng, Y. L. | Nurs Crit Care | 2025 |
delirium dose–response analysis intensive care unit (ICU) music therapy |
| Development of a LASSO machine learning algorithm-based model for postoperative delirium prediction in hepatectomy patients | Zhu, Y. Liang, R. Wang, Y. Yang, J. J. Zhou, N. Zhou, C. M. | BMC Surg | 2025 |
Humans *Hepatectomy/adverse effects Female Male *Machine Learning *Nomograms *Delirium/diagnosis/etiology/epidemiology *Postoperative Complications/diagnosis/epidemiology/etiology Middle Aged Aged Risk Factors Algorithms ROC Curve Hepatectomy Lasso Nomogram Pod Predicting |
| Ultrasound-guided femoral nerve block reduced the incidence of postoperative delirium after total knee arthroplasty: A double-blind, randomized study | Ultrasound-guided femoral nerve block reduced the incidence of postoperative delirium after total knee arthroplasty: A double-blind, randomized study | Medicine (Baltimore) | 2024 |
Humans *Arthroplasty, Replacement, Knee/adverse effects/methods Aged *Nerve Block/methods Male Female *Femoral Nerve Double-Blind Method *Ultrasonography, Interventional/methods Incidence *Pain, Postoperative/prevention & control/epidemiology/etiology Aged, 80 and over Delirium/prevention & control/etiology/epidemiology Postoperative Complications/prevention & control/epidemiology/etiology Pain Measurement |
| Preemptive hydromorphone analgesia reduces postoperative delirium and stress response in laparoscopic cholecystectomy patients | Zhang, W. Yang, Y. Yan, Y. | Am J Transl Res | 2024 |
Hydromorphone hydrochloride laparoscopic cholecystectomy postoperative delirium preemptive analgesia stress response |
| Evaluating the effectiveness of a clinical decision support system (AI-Antidelirium) to improve Nurses' adherence to delirium guidelines in the intensive care unit | Zhang, S. Ding, S. Cui, W. Li, X. Wei, J. Wu, Y. | Intensive Crit Care Nurs | 2025 |
Adherence Artificial intelligence Clinical Decision Supporting System Delirium Intensive care unit |
| The global research trends in perioperative cognitive function protection for preventing postoperative delirium: A bibliometric analysis | Zeng, Y. Yu, J. Zhang, J. Song, M. Gao, X. | J Clin Neurosci | 2025 |
Bibliometric Analysis Cognitive Function Global Trend Postoperative Delirium Visualized Analysis |
| Effectiveness of non-pharmacological intervention protocol for prevention of postoperative delirium in the surgical intensive care unit | Yuyen, T. Narksut, A. Lao-Amornphunkul, S. Thanakiattiwibun, C. Pansangar, C. Thikom, N. Chaiwat, O. Piriyapatsom, A. | Sci Rep | 2025 |
Humans Aged Male Female *Intensive Care Units *Delirium/prevention & control/epidemiology *Postoperative Complications/prevention & control/epidemiology Incidence Aged, 80 and over Treatment Outcome Delirium prevention Elderly patients Non-pharmacological intervention Postoperative delirium Prevention Surgical intensive care unit |
| Delirium after deep brain stimulation for Parkinson's disease: a meta-analysis of incidence and risk factors | Yousef, O. Abouelmagd, M. E. Abbas, A. Elrosasy, A. Shbani, A. Raslan, A. M. | Neurosurg Rev | 2025 |
Humans *Deep Brain Stimulation/adverse effects/methods *Parkinson Disease/therapy Risk Factors *Delirium/epidemiology/etiology Incidence Postoperative Complications/epidemiology Deep brain stimulation Delirium Parkinsonism Parkinson’s disease |
| Early Screening for Confusion and Vitamin D Deficiency in Elderly Hip Fracture Patients: A Quality Improvement Initiative to Mitigate the Risk of Postoperative Delirium | Younis, Z. Gurukiran, G. Abdullah, F. Kumar, S. Ford, D. Hamid, M. A. Wani, K. F. | Cureus | 2024 |
cognitive screening elderly patient care hip fracture management postoperative delirium vitamin d deficiency |
| Disproportionality analysis of amenamevir-induced encephalopathy using the Japanese adverse drug event report database | Yamada, T. Ogawa, T. Tanaka, T. Kusaka, Y. Nishihara, M. Ashida, A. | J Infect Chemother | 2025 |
Humans Female Male Retrospective Studies Aged Japan/epidemiology Middle Aged *Adverse Drug Reaction Reporting Systems/statistics & numerical data *Brain Diseases/chemically induced/epidemiology Risk Factors *Antiviral Agents/adverse effects Aged, 80 and over Databases, Factual/statistics & numerical data Herpes Zoster/epidemiology Adult East Asian People Adverse event Amenamevir Encephalopathy Pharmacovigilance |
| Cardiac surgery outcomes: The efficacy of dexmedetomidine in reducing postoperative delirium - A bibliometric study | Yabo, W. Dongxu, L. Xiao, L. Qi, A. | Curr Probl Cardiol | 2025 |
Cardiac surgery Cite space analysis Dexmedetomidine Postoperative delirium Visualized analysis α2-adrenoceptor |
| The impact of remimazolam compared to propofol on postoperative delirium: a systematic review and meta-analysis | Xue, X. Ma, X. Zhao, B. Liu, B. Zhang, J. Li, Z. Li, H. Liu, X. Zhao, S. | Minerva Anestesiol | 2025 |
Benzodiazepines, postoperative delirium, review, propofol, remimazolam |
| Impact of delirium on post-discharge mortality in coronary care unit patients: A retrospective cohort study | Xu, H. B. Shu, M. Wu, J. J. Li, R. F. Lin, X. H. Zhang, H. G. | Nurs Crit Care | 2025 |
coronary care unit delirium mortality survivors |
| Effects of Sensory-Based Interventions on Delirium Prevention in Critically Ill Patients: A Systematic Review and Meta-Analysis | Xu, C. Zhang, Y. Yuan, D. Wang, C. Wang, X. Liang, X. Wang, J. Duan, J. | Int J Nurs Pract | 2025 |
Humans *Delirium/prevention & control/epidemiology *Critical Illness Randomized Controlled Trials as Topic delirium intensive care meta‐analysis sensory‐based interventions |
| The association between the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio and delirium in ischemic stroke patients | Wang, P. Huang, J. Xu, L. Hu, R. | Front Med (Lausanne) | 2024 |
Mendelian randomization delirium inflammation ischemic stroke risk factor |
| Risk Factors and Pain Management in the Incidence of Postoperative Delirium in Elderly Patients: A Retrospective Study | Vizerie, L. Morales, T. Galey, S. Montel, F. Velly, L. Bruder, N. Simeone, P. | J Clin Med | 2024 |
pain management postoperative delirium postoperative pain risks factors surgery |
| Exploring factors influencing delirium incidence: Insights from the Alzira cohort study, 2012-2021 | Villalón-Rubio, D. García-Tercero, E. López-Gómez, J. González, H. Belenguer-Varea, Á Cunha-Pérez, C. Germán Borda, M. Tarazona-Santabalbina, F. J. | Rev Esp Geriatr Gerontol | 2025 |
Humans *Delirium/epidemiology Male Female Aged Aged, 80 and over *Hip Fractures/complications/epidemiology Hospitalization Incidence Retrospective Studies Risk Factors Spain/epidemiology Delirium Fractura de cadera Hip fracture Mortalidad Mortality |
| Can Neutrophil-to-Lymphocyte Ratio, Platelet Volume, and Platelet Distribution Width Be Used as Indicators of Delirium? | Tuncer, B. Çelik, F. Çelik, B. Erkılıç, E. | J Clin Med | 2024 |
children general anesthesia neutrophil/lymphocyte ratio postoperative delirium |
| The effect of type of anaesthetic on delirium after surgery for acute hip fracture: An instrumental variable analysis to assess causation | Tanios, A. G. Gallagher, E. L. McManus, M. S. Riordan, J. A. Harris, I. A. Harvey, L. A. | Anaesth Intensive Care | 2025 |
Anaesthesia Australia New Zealand conduction anaesthesia delirium general anaesthesia hip fractures multicentre studies registries retrospective studies |
| Incidence of Delirium during the Initiation Phase of Morphine and Hydromorphone Therapy in Cancer Patients: A Retrospective Comparative Study | Tanaka, H. Tanaka, R. Kamoshida, T. Morimoto, S. Sato, J. Ishikawa, H. Sato, T. Sato, T. Saitoh, A. Yamada, D. Kondo, M. Takahashi, K. Takahashi, C. Shino, M. | Can J Hosp Pharm | 2025 |
delirium hydromorphone morphine oral opioids |
| Intravenous dexmedetomidine for delirium prevention in elderly patients following orthopedic surgery: a meta-analysis of randomized controlled trials | Sun, J. Wang, D. Zhao, Y. Bai, Y. Wang, S. Meng, C. Miao, G. Liu, P. | BMC Pharmacol Toxicol | 2025 |
Humans *Dexmedetomidine/administration & dosage/therapeutic use *Randomized Controlled Trials as Topic *Orthopedic Procedures/adverse effects *Delirium/prevention & control Aged *Postoperative Complications/prevention & control Hypnotics and Sedatives/administration & dosage/therapeutic use Administration, Intravenous Delirium Dexmedetomidine Orthopedic surgery |
| Postoperative delirium under general anaesthesia by remimazolam versus propofol: A systematic review and meta-analysis of randomised controlled trials | Suga, M. Yasuhara, J. Watanabe, A. Takagi, H. Kuno, T. Nishimura, T. Ijuin, S. Taira, T. Inoue, A. Ishihara, S. Pakavakis, A. Glassford, N. Shehabi, Y. | J Clin Anesth | 2025 |
Humans *Propofol/adverse effects/administration & dosage *Anesthesia, General/adverse effects *Randomized Controlled Trials as Topic *Hypnotics and Sedatives/administration & dosage/adverse effects *Benzodiazepines/adverse effects/administration & dosage Incidence Emergence Delirium/prevention & control/epidemiology Delirium/epidemiology/prevention & control/chemically induced Hypotension/chemically induced/epidemiology Postoperative Complications/epidemiology/prevention & control Anesthetics, Intravenous/adverse effects/administration & dosage General anaesthesia Intraoperative hypotension Postoperative delirium (POD) Postoperative delirium and cognitive dysfunction (POCD) Propofol Remimazolam |
| Association between delirium severity and prognosis following Transcatheter aortic valve implantation | Suenaga, T. Ishizu, K. Shirai, S. Yoshida, S. Wakugawa, H. Miyahara, K. Yamamoto, K. Otani, A. Miyawaki, N. Nakano, K. Ko, E. Yoshino, Y. Tsuru, Y. Nakamura, M. Morofuji, T. Hayashi, M. Isotani, A. Ohno, N. Kakumoto, S. Ando, K. | J Cardiol | 2025 |
Delirium Frailty Prognosis Transcatheter aortic valve implantation |
| Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium: A Cluster Randomized Crossover Trial | Spence, J. Devereaux, P. J. Lee, S. F. D'Aragon, F. Avidan, M. S. Whitlock, R. P. Mazer, C. D. Rousseau-Saine, N. Rajamohan, R. R. Pryor, K. O. Klein, R. Tan, E. Cameron, M. J. Di Sante, E. DeBorba, E. Mustard, M. E. Couture, E. J. Zamper, R. P. C. Law, M | JAMA Surg | 2025 |
delirium, cardiac surgery, postoperative delirium, benzodiazepines |
| Protein alterations in patients with delirium after cardiac surgery: An exploratory case-control sub-study of the VISION Cardiac Surgery Biobank | Spence, J. Devereaux, P. J. Bashir, S. Brady, K. Sun, T. Chan, M. T. V. Wang, C. Y. Lamy, A. Whitlock, R. P. McIntyre, W. F. Belley-Côté, E. Paré, G. Chong, M. | Anesthesiology | 2025 |
Delirium, biomarkers, Postoperative delirium, Olink, Proteins |
| Prevention of Delirium in the Intensive Care Unit through Nonpharmacological Interventions: An Umbrella Review | Sonia, M. Kaur, S. Kothari, N. | Indian J Crit Care Med | 2025 |
Critical care Delirium Meta-analysis Nonpharmacological interventions Systematic review |
| Prioritization Patterns of Nurses in the Management of a Patient With Delirium: Results of a Q-Methodology Study | Sist, L. Pezzolati, M. Ugenti, N. V. Cedioli, S. Messina, R. Chiappinotto, S. Rucci, P. Palese, A. | Res Nurs Health | 2025 |
Q‐methodology delirium delirium/nursing management prioritization priority setting |
| Analysis of Delirium Risk Assessment Tools for Prediction of Postoperative Delirium Following Lumbar Spinal Fusion | Singh, M. Sahhar, M. Nassar, J. E. Farias, M. J. Rasquinha, R. Kim, J. Diebo, B. G. Daniels, A. H. | Spine (Phila Pa 1976) | 2025 |
Delirium Risk Assessment Score Delirium Risk Assessment Tool Delirium Elderly At-Risk Postoperative delirium Posterior lumbar fusion |
| The Presence/Absence of an Awake-State Dominant EEG Rhythm in Delirious Patients Is Related to Different Symptoms of Delirium Evaluated by the Intensive Care Delirium Screening Checklist (ICDSC) | Shinba, T. Fujita, Y. Ogawa, Y. Shinba, Y. Shinba, S. | Sensors (Basel) | 2024 |
Humans *Delirium/diagnosis/physiopathology *Electroencephalography/methods Male Female Aged Middle Aged *Wakefulness/physiology Checklist Aged, 80 and over Critical Care/methods Intensive Care Delirium Screening Checklist delirium dominant rhythm electroencephalography eyes opening and closing hallucination or delusion symptom fluctuation |
| Unveiling the Immune Landscape of Delirium through Single-Cell RNA Sequencing and Machine Learning: Towards Precision Diagnosis and Therapy | Shi, Y. Xu, P. | Psychogeriatrics | 2025 |
Humans *Machine Learning *Sequence Analysis, RNA/methods Male *Delirium/diagnosis/genetics Female Aged Biomarkers/blood Leukocytes, Mononuclear/metabolism/immunology Middle Aged Signal Transduction/genetics Single-Cell Analysis/methods Proto-Oncogene Proteins c-akt/genetics Postoperative Complications/diagnosis Case-Control Studies machine learning peripheral blood mononuclear cells postoperative delirium single‐cell RNA sequencing |