What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Fixed dose ketamine for prehospital management of hyperactive delirium with severe agitation
- Authors
- O'Brien, M. C. Kelleran, K. J. Burnett, S. J. Hausrath, K. A. Kneer, M. S. Nan, N. Ma, C. X. McCartin, R. W. Clemency, B. M.
- Year
- 2024
- Journal
- Am J Emerg Med
- Abstract
INTRODUCTION: Patients exhibiting signs of hyperactive delirium with severe agitation (HDSA) may require sedating medications for stabilization and safe transport to the hospital. Determining the patient’s weight and calculating the correct weight-based dose may be challenging in an emergency. A fixed dose ketamine protocol is an alternative to the traditional weight-based administration, which may also reduce dosing errors. The objective of this study was to evaluate the frequency and characteristics of adverse events following pre-hospital ketamine administration for HDSA. METHODS: Emergency Medical Services (EMS) records from four agencies were searched for prehospital ketamine administration. Cases were included if a 250 mg dose of ketamine was administered on standing order to an adult patient for clinical signs consistent with HDSA. Protocols allowed for a second 250 mg dose of ketamine if the first dose was not effective. Both the 250 mg initial dose and the total prehospital dose were analyzed for weight based dosing and adverse events. RESULTS: Review of 132 cases revealed 60 cases that met inclusion criteria. Patients’ median weight was 80 kg (range: 50-176 kg). No patients were intubated by EMS, one only requiring suction, three required respiratory support via bag valve mask (BVM). Six (10%) patients were intubated in the emergency department (ED) including the three (5%) supported by EMS via BVM, three (5%) others who were sedated further in the ED prior to requiring intubation. All six patients who were intubated were discharged from the hospital with a Cerebral Performance Category (CPC) 1 score. The weight-based dosing equivalent for the 250 mg initial dose (OR: 2.62, CI: 0.67-10.22) and the total prehospital dose, inclusive of the 12 patients that were administered a second dose, (OR: 0.74, CI: 0.27, 2.03), were not associated with the need for intubation. CONCLUSION: The 250 mg fixed dose of ketamine was not >5 mg/kg weight-based dose equivalent for all patients in this study. Although a second 250 mg dose of ketamine was permitted under standing orders, only 12 (20%) of the patients were administered a second dose, none experienced an adverse event. This indicates that the 250 mg initial dose was effective for 80% of the patients. Four patients with prehospital adverse events likely related to the administration of ketamine were found. One required suction, three (5%) requiring BVM respiratory support by EMS were subsequently intubated upon arrival in the ED. All 60 patients were discharged from the hospital alive. Further research is needed to determine an optimal single administration dose for ketamine in patients exhibiting signs of HDSA, if employing a standardized fixed dose medication protocol streamlines administration, and if the fixed dose medication reduces the occurrence of dosage errors.
- PMID
PMID: 38626643
- Keywords
Humans
*Ketamine/administration & dosage/therapeutic use
*Delirium/drug therapy
*Emergency Medical Services/methods
Male
Female
Middle Aged
*Psychomotor Agitation/drug therapy
Aged
Adult
Retrospective Studies
Aged, 80 and over
Anesthetics, Dissociative/administration & dosage/therapeutic use
Body Weight
Hyperactive delirium
Ketamine
Prehospital care
Sedation
Weight-based dose
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| The effect of music therapy on delirium in patients receiving mechanical ventilatory support in the Intensive Care Unit: A protocol for systematic review and meta-analysis | Zhou, C. Ma, H. Qi, X. Xu, C. Liang, Z. | Medicine (Baltimore) | 2023 |
Humans, *Delirium/drug therapy, Intensive Care Units, *Meta-Analysis as Topic, *Music Therapy, *Systematic Reviews as Topic/methods |
| Incidence of and risk factors for post-intensive care syndrome among Chinese respiratory intensive care unit patients: A cross-sectional, prospective study | Zhou, M. Zhang, J. Xu, Z. Gu, H. Chen, Z. Ding, Y. | Aust Crit Care | 2023 |
Humans, Prospective Studies, Incidence, *Quality of Life, Cross-Sectional Studies, *Activities of Daily Living, East Asian People, Intensive Care Units, Risk Factors, Effect factors, Patients, Post–intensive care syndrome, Respiratory intensive care unit |
| The Impact of an Educational Programme on Jordanian Intensive Care Nurses' Knowledge, Attitudes, and Practice Regarding Delirium and their Levels of Self-Efficacy: A Quasi-Experimental Design | Alhalaiqa, F. Masa'Deh, R. Al Omari, O. Shawashreh, A. Khalifeh, A. H. Gray, R. | Iran J Nurs Midwifery Res | 2023 |
Attitude, delirium, education, intensive care units, knowledge, self efficacy |
| Nonpharmacological interventions for agitation in the adult intensive care unit: A systematic review | Adams, A. M. N. Chamberlain, D. Grønkjær, M. Brun Thorup, C. Conroy, T. | Aust Crit Care | 2023 |
Adult, Humans, Intensive Care Units, Psychomotor Agitation/therapy, Critical care, Delirium, Intensive care unit, Nonpharmacological interventions, Nursing, Psychomotor agitation, Systematic review |
| Postoperative Outcomes in Elderly Patients Undergoing Cardiac Surgery With Preoperative Cognitive Impairment: A Systematic Review and Meta-Analysis | Au, E. Thangathurai, G. Saripella, A. Yan, E. Englesakis, M. Nagappa, M. Chung, F. | Anesth Analg | 2023 |
Human, Aged, Delirium/etiology/complications, Cognitive, Dysfunction/complications, Postoperative Complications/diagnosis/etiology, Cardiac Surgical Procedures/adverse effect, Intensive Care Units |
| The prediction of postoperative delirium with the preoperative bispectral index in older aged patients: a cohort study | Bao, L. Liu, T. Zhang, Z. Pan, Q. Wang, L. Fan, G. Li, Z. Yin, Y. | Aging Clin Exp Res | 2023 |
Bis, Elderly patients, Monitoring, Postoperative delirium, Prediction, Preoperative predictive score |
| Insulin resistance, age and depression's impact on cognition in middle-aged adults from the PREVENT cohort | Bauermeister, S. D. Ben Yehuda, M. Reid, G. Howgego, G. Ritchie, K. Watermeyer, T. Gregory, S. Terrera, G. M. Koychev, I. | BMJ Ment Health | 2023 |
Middle Aged, Humans, Adult, Aged, Diabetes Mellitus, Type 2/epidemiology, Insulin Resistance, Depression/epidemiology, Cohort Studies, Cross-Sectional Studies, Cognition, Alzheimer Disease/psychology, delirium & cognitive disorders, depression & mood disorders, psychiatry |
| Key elements of an evidence-based clinical psychology service within adult critical care | Beadman, M. Carraretto, M. | J Intensive Care Soc | 2023 |
Psychology, critical care, delirium, follow-up clinics, post-intensive care syndrome |
| Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation? | Bircak-Kuchtova, B. Chung, H. Y. Wickel, J. Ehler, J. Geis, C. | Crit Care | 2023 |
Humans, Sepsis-Associated Encephalopathy/complications/diagnosis, Intermediate Filaments, Sepsis/complications/diagnosis, Biomarkers, Brain Diseases, Biomarker, Brain dysfunction, Delirium, Encephalopathy, Neurofilament light chain, Sae, Sepsis |
| Veterans' experiences of moral injury, treatment and recommendations for future support | Bonson, A. Murphy, D. Aldridge, V. Greenberg, N. Williamson, V. | BMJ Mil Health | 2023 |
anxiety disorders, delirium & cognitive disorders, depression & mood disorders, public health |
| General Anesthesia Versus Regional Anesthesia in the Elderly Patients Undergoing Hip Fracture Surgeries: A Systematic Review and Meta-Analysis of Randomized Clinical Trials | Cao, M. M. Zhang, Y. W. Sheng, R. W. Gao, W. Kang, Q. R. Gao, Y. C. Qiu, X. D. Rui, Y. F. | World J Surg | 2023 |
Humans, Aged, Emergence Delirium, Blood Loss, Surgical/prevention & control, Postoperative Complications/epidemiology/etiology, Randomized Controlled Trials as Topic, Anesthesia, General, Anesthesia, Conduction, Hip Fractures/surgery |
| Delirium in ventilated patients receiving fentanyl and morphine for Analgosedation: Findings from the ANALGESIC trial | Casamento, A. Neto, A. S. Lawrence, M. Chudleigh, L. Browne, E. Taplin, C. Eastwood, G. M. Bellomo, R. | J Crit Care | 2023 |
Analgosedation, Delirium, Mechanical ventilation, Opioids |
| Postoperative delirium after intracranial neurosurgery: A prospective cohort study from a developing nation | Chakrabarti, D. Bharadwaj, S. Akash, V. S. Wadhwa, A. Konar, S. Kamath, S. Gopalakrishna, K. N. | Acta Neurochir (Wien) | 2023 |
Humans, Emergence Delirium/complications, Delirium/epidemiology/etiology |
| Incidence of preoperative instrumental activities of daily living (IADL) dependence and adverse outcomes in older surgical patients: A systematic review and meta-analysis | Chen, A. An, E. Yan, E. He, D. Saripella, A. Butris, N. Tsang, J. Englesakis, M. Wong, J. Alibhai, S. Chung, F. | J Clin Anesth | 2023 |
Delirium, systematic review and meta-analysis, Functional dependence,, Instrumental activities of daily living (IADL), Older patients, Preoperative assessment |
| Heterogeneity in the definition of delirium in ICUs and association with the intervention effect in randomized controlled trials: a meta-epidemiological study | Collet, L. Lanore, A. Alaterre, C. Constantin, J. M. Martin, G. L. Caille, A. James, A. Dechartres, A. | Crit Care | 2023 |
Humans, Delirium/diagnosis/epidemiology/therapy, Epidemiologic Studies, Intensive Care Units, Randomized Controlled Trials as Topic, Meta-Analysis as Topic, Definition, Delirium, Heterogeneity, Intensive care, Meta-analysis, Meta-epidemiology |
| A prospective multicentre observational study to quantify nocturnal light exposure in intensive care | Craig, T. Mathieu, S. Morden, C. Patel, M. Matthews, L. | J Intensive Care Soc | 2023 |
Light, circadian rhythm, delirium, environment, light pollution |
| Recognizing and Reducing Delirium in the Intensive Care Unit | Dechant, T. Smith, L. Chavez, J. | Crit Care Nurs Q | 2023 |
Humans, Disease Progression, Intensive Care Units |
| Postoperative Deep Sedation after Microvascular Reconstructive Surgery for Oral Cancer Increases the Risk of Early Postoperative Pneumonia | Fukuzawa, S. Yamagata, K. Takaoka, S. Uchida, F. Ishibashi-Kanno, N. Yanagawa, T. Bukawa, H. | Dent J (Basel) | 2023 |
oral cancer, postoperative delirium, postoperative pneumonia, postoperative sedation, reconstructive surgery |
| Heart rate response and recovery during exercise predict future delirium risk-A prospective cohort study in middle- to older-aged adults | Gao, L. Gaba, A. Li, P. Saxena, R. Scheer, Fajl Akeju, O. Rutter, M. K. Hu, K. | J Sport Health Sci | 2023 |
Male, Humans, Adult, Middle Aged, Female, Heart Rate/physiology, Prospective Studies, Exercise/physiology, Risk Factors, Delirium, Brain health, Delirium, Exercise stress test |
| Circadian Rest-Activity Rhythms, Delirium Risk, and Progression to Dementia | Gao, L. Li, P. Gaykova, N. Zheng, X. Gao, C. Lane, J. M. Saxena, R. Scheer, Fajl Rutter, M. K. Akeju, O. Hu, K. | Ann Neurol | 2023 |
Middle Aged, Humans, Sleep, Circadian Rhythm, Rest, Actigraphy, Sleep Wake Disorders, Dementia/etiology, Delirium/etiology |
| Frequency and Risk Factors of Subsyndromal Delirium in the Intensive Care Units: A Prospective Cohort Study | Gao, Y. Gong, S. Zhou, W. Li, X. Gan, X. | Neuropsychiatr Dis Treat | 2023 |
Icu, intensive care units, prevalence, risk factors, subsyndromal delirium |
| Calibration of the PREdiction of DELIRium in ICu Patients (PRE-DELIRIC) Score in a Cohort of Critically Ill Patients: A Retrospective Cohort Study | Gravante, F. Giannarelli, D. Pucci, A. Pisani, L. Latina, R. | Dimens Crit Care Nurs | 2023 |
Humans, Calibration, Critical Illness, Retrospective Studies, Nonoxynol, Delirium, Intensive Care Units |
| Surgeon-Specific Treatment Selection Bias and Heterogeneous Perioperative Practices in an Observational Spine Surgery Study. A Statistical Tutorial with Implications for Analysis of Observational Studies of Perioperative Interventions | Hindman, B. J. Gold, C. J. Ray, E. Wendt, L. H. Ten Eyck, P. Berger, J. I. Olinger, C. R. Banks, M. I. Sanders, R. D. Howard, M. A., 3rd Woodroffe, R. W. | World Neurosurg | 2023 |
Adult, Humans, Antifibrinolytic Agents/therapeutic use, Retrospective Studies, Selection Bias, Tranexamic Acid/therapeutic use, Blood Loss, Surgical, Surgeons, Delirium, Logistic regression, Propensity score, Spinal fusion, Surgical technique, Tranexamic acid |
| Relationship Between Delirium Development and Its Causative Factors in the Intensive Care Unit After Cardiac Surgery | Hori, Y. Mihashi, M. | Yonago Acta Med | 2023 |
cardiac surgery, delirium, intensive care unit, postoperative complications, risk factors |
| Effect of Repeated Intranasal Administration of Different Doses of Insulin on Postoperative Delirium, Serum τ and Aβ Protein in Elderly Patients Undergoing Radical Esophageal Cancer Surgery | Huang, Q. Shi, Q. Yi, X. Zeng, J. Dai, X. Lin, L. Yang, Y. Wu, X. Gong, G. | Neuropsychiatr Dis Treat |
Aβ protein, aged, intranasal insulin, postoperative delirium, τ protein |
|
| Delirium screening in a stroke unit by nurses using 4AT: Results from a quality improvement project | Ihle-Hansen, H. Johnsen, N. Jankowiak, T. Hagberg, G. Walle-Hansen, M. M. Landgraff, I. Høvik, G. Graven, E. Myrstad, M. | Nurs Open | 2023 |
4at, delirium, minor stroke, nurse, post-stroke |
| A Review of Biomarkers in Delirium Superimposed on Dementia (DSD) and Their Clinical Application to Personalized Treatment and Management | Jahangir, S. Allala, M. Khan, A. S. Muyolema Arce, V. E. Patel, A. Soni, K. Sharafshah, A. | Cureus | 2023 |
bioinformatics, delirium, delirium superimposed dementia, dementia, geriatrics, hsa-mir-17, neurology, psychiatry |
| Factors Affecting Delirium in ICU Patients | Jeong, I. S. Cho, M. K. | Int J Environ Res Public Health | 2023 |
Humans, Retrospective Studies, Delirium/diagnosis/epidemiology, Intensive Care Units, Hypnotics and Sedatives, Pain/complications, Risk Factors, Glasgow coma scale, blood urea nitrogen, delirium, intensive care unit, length of stay, morse fall scale, restraints, simplified acute physiology score |
| The Combined Effect of Delirium and Falls on Length of Stay and Discharge | Kalivas, B. Zhang, J. Harper, K. Dulin, J. Heincelman, M. Marsden, J. Hunt, K. J. Mauldin, P. D. Moran, W. P. Thomas, M. K. | J Healthc Qual | 2023 |
Humans, Length of Stay, Patient Discharge, Cross-Sectional Studies, Hospitalization, Delirium, Retrospective Studies |
| Effect of using eye masks and earplugs in preventing delirium in intensive care patients: A single-blinded, randomized, controlled trial | Kiliç, G. Kav, S. | Nurs Crit Care | 2023 |
delirium, earplugs, eye masks, intensive care unit (ICU), nonpharmacological interventions |
| Computed tomographic bone mineral density is independently associated with adverse in-hospital outcomes in Dutch level-1 trauma patients | Kobes, T. Sweet, A. A. R. Verstegen, S. B. H. Houwert, R. M. Veldhuis, W. B. Leenen, L. P. H. de Jong, P. A. van Baal, Mcpm | Eur J Trauma Emerg Surg | 2023 |
Male, Humans, Middle Aged, Female, Bone Density, Osteoporosis, Absorptiometry, Photon/methods, Tomography, X-Ray Computed/methods, Lumbar Vertebrae/diagnostic imaging, Hospitals, Delirium, Retrospective Studies, Bone mineral density, Computed tomography, In-hospital complications, Opportunistic screening, Trauma patients |
| Yokukansan (TJ-54) in patients undergoing surgery: A systematic review and meta-analysis | Kotake, K. Matsunuma, S. Takahashi, T. Kitamura, N. Kawakami, Y. | Geriatr Nurs | 2023 |
Adverse events, Anxiety, Postoperative delirium, Systematic review, Yokukansan |
| Pattern of Inpatient Consultation-liaison Psychiatry Utility in a Tertiary Care Hospital | Kumar, P. Chaudhary, R. Bhalla, J. K. Gupta, A. | Int J Appl Basic Med Res | 2023 |
Consultation liaison psychiatry, delirium, drug withdrawal, emergency |
| Machine learning-based prediction model for postoperative delirium in non-cardiac surgery | Lee, D. Y. Oh, A. R. Park, J. Lee, S. H. Choi, B. Yang, K. Kim, H. Y. Park, R. W. | BMC Psychiatry | 2023 |
Humans, Male, Emergence Delirium, Algorithms, Area Under Curve, Hospitals, Machine Learning, Delirium, Non-cardiac surgery |
| Preoperative slow-wave sleep is associated with postoperative delirium after heart valve surgery: A prospective pilot study | Lin, Y. Xu, S. Peng, Y. Li, S. Huang, X. Chen, L. | J Sleep Res | 2023 |
delirium, sleep architecture, slow-wave sleep, valve surgery |
| The relationship between major depression and delirium: A two-sample Mendelian randomization analysis | Li, J. Wang, J. Yang, M. Wang, G. Xu, P. | J Affect Disord | 2023 |
Delirium, Depression, Genetic, Mendelian randomization |
| Preoperative cerebrospinal fluid biomarkers may be associated with postoperative delirium in patients undergoing knee/hip arthroplasty: the PNDABLE study | Lin, Y. Yu, N. Lin, X. Deng, X. Liu, F. Tao, H. Dong, R. Wang, B. Bi, Y. | BMC Geriatr | 2023 |
Humans, Aged, Amyloid beta-Peptides/cerebrospinal fluid, Emergence Delirium, Arthroplasty, Replacement, Hip/adverse effects, Aging, Biomarkers/cerebrospinal fluid, Peptide Fragments, Alzheimer Disease/diagnosis |
| Associated factors for postoperative delirium following major abdominal surgery: A systematic review and meta-analysis | Liu, J. Li, J. Wang, J. Zhang, M. Han, S. Du, Y. | Int J Geriatr Psychiatry | 2023 |
Humans, Emergence Delirium/complications, Delirium/epidemiology/etiology/diagnosis, Postoperative, Complications/epidemiology/etiology/diagnosis, Risk Factors, Risk Assessment, major abdominal surgery, meta-analysis, postoperative delirium, systematic review |
| Detecting delirium: a systematic review of ultrabrief identification instruments for hospital patients | Liu, Y. Li, Z. Li, Y. Ge, N. Yue, J. | Front Psychol | 2023 |
delirium, measurement, older patients, psychometrics, systematic review |
| Biomarkers of delirium risk in older adults: a systematic review and meta-analysis | Lozano-Vicario, L. García-Hermoso, A. Cedeno-Veloz, B. A. Fernández-Irigoyen, J. Santamaría, E. Romero-Ortuno, R. Zambom-Ferraresi, F. Sáez de Asteasu, M. L. Muñoz-Vázquez Á, J. Izquierdo, M. Martínez-Velilla, N. | Front Aging Neurosci | 2023 |
biomarkers, cognitive impairment, delirium, neuroinflammation, older people |
| Perioperative outcomes in different anesthesia techniques for patients undergoing hip fracture surgery: a systematic review and meta-analysis | Ma, B. Xie, H. Ling, H. Ma, W. | BMC Anesthesiol | 2023 |
Humans, Prospective Studies, Retrospective Studies, Hip Fractures/surgery, Anesthesia, Conduction, Anesthesia, General, Postoperative Complications/epidemiology, Emergence Delirium/epidemiology, Delirium, General anesthesia, Hip fractures, Mortality, Pneumonia, Regional anesthesia |
| Diagnostic accuracy of the 3-minute diagnostic interview for confusion assessment method-defined delirium in delirium detection: a systematic review and meta-analysis | Ma, R. Zhao, J. Li, C. Qin, Y. Yan, J. Wang, Y. Yu, Z. Zhang, Y. Zhao, Y. Huang, B. Sun, S. Ning, X. | Age Ageing | 2023 |
Humans, Aged, Delirium/diagnosis, Sensitivity and Specificity, Intensive Care Units, Hospitals, Patients’ Rooms, 3-minute diagnostic interview for CAM-defined delirium (3D-CAM), delirium, meta-analysis |
| Improving the Prevention, Detection, and Management of Delirium in Adult Inpatients; an Interprofessional Consultative Team Pilot Project | Monaghan, C. Kerr, J. Ali, A. Amer, S. Ma, J. Abraham, C. Simpson, K. Marcucci, M. Carter, A. Rizvi, Z. Jones-Lim, L. Peters, M. L. Versloot, J. | Gerontol Geriatr Med | 2023 |
consultative team, delirium, hospital medicine, interprofessional, quality improvement |
| Recall of delirium and related distress in elderly hospitalized patients: A prospective study | Moura, M. L. Martins, S. Correia, R. Pinho, E. Paulo, C. Silva, M. J. Teixeira, A. Fontes, L. Lopes, L. Paiva, J. A. Azevedo, L. F. Fernandes, L. | Porto Biomed J | 2023 |
critical care, delirium, psychological distress, recall |
| Supervised deep learning with vision transformer predicts delirium using limited lead EEG | Mulkey, M. A. Huang, H. Albanese, T. Kim, S. Yang, B. | Sci Rep | 2023 |
Humans, Aged, Delirium, Critical Illness, Deep Learning, Patient Discharge, Electroencephalography, Intensive Care Units |
| Duration of Surgery and Intraoperative Blood Pressure Management are Modifiable Risk Factors for Postoperative Neurocognitive Disorders Following Spine Surgery: Results of the Prospective CONFESS Study | Müller, J. Nowak, S. Weidemeier, M. Vogelgesang, A. Ruhnau, J. von Sarnowski, B. Saar, A. Veser, Y. Behr, F. Gross, S. Rathmann, E. Schmidt, S. Rehberg, S. Usichenko, T. Hahnenkamp, K. Ehler, J. Flöel, A. Schroeder, H. W. S. Müller, J. U. Fleischmann, | Spine (Phila Pa 1976) | 2023 |
postoperative delirium, neurocognitive disorders, surgical, postoperative cognitive dysfunction, aging |
| The impact of a preoperative nurse-led orientation program on postoperative delirium after cardiovascular surgery: a retrospective single-center observational study | Nakamura, R. Miyamoto, K. Tsuji, K. Ozaki, K. Kunimoto, H. Honda, K. Nishimura, Y. Kato, S. | J Intensive Care | 2023 |
Cardiovascular surgery, Intensive care unit, Non-pharmacological approach, Postoperative delirium |
| Association Between Postoperative Delirium and Long-Term Subjective Cognitive Decline in Older Patients Undergoing Cardiac Surgery: A Secondary Analysis of the Minimizing Intensive Care Unit Neurological Dysfunction with Dexmedetomidine-Induced Sleep Tria | Namirembe, G. E. Baker, S. Albanese, M. Mueller, A. Qu, J. Z. Mekonnen, J. Wiredu, K. Westover, M. B. Houle, T. T. Akeju, O. | J Cardiothorac Vasc Anesth | 2023 |
cardiac surgery, cognition, delirium, postoperative, subjective cognitive decline |
| Outcomes with spinal versus general anesthesia for patients with and without preoperative cognitive impairment: Secondary analysis of a randomized clinical trial | O'Brien, K. Feng, R. Sieber, F. Marcantonio, E. R. Tierney, A. Magaziner, J. Carson, J. L. Dillane, D. Sessler, D. I. Menio, D. Ayad, S. Stone, T. Papp, S. Schwenk, E. S. Marshall, M. Jaffe, J. D. Luke, C. Sharma, B. Azim, S. Hymes, R. Chin, K. J. Sheppar | Alzheimers Dement | 2023 |
anesthesia, delirium, dementia, hip fracture, mild cognitive impairment, surgery |
| Age-dependent differences and similarities in the plasma proteomic signature of postoperative delirium | Oren, R. L. Kim, E. J. Leonard, A. K. Rosner, B. Chibnik, L. B. Das, S. Grodstein, F. Crosby, G. Culley, D. J. | Sci Rep | 2023 |
Middle Aged, Humans, Aged, Emergence Delirium, Proteomics, Interleukin-8, Postoperative Complications, Delirium/etiology, Asialoglycoprotein Receptor |
| Delirium education and post-anaesthetics care unit nurses' knowledge on recognising and managing delirium in older patients | Ormonde, C. Igwe, E. O. Nealon, J. O'Shaughnessy, P. Traynor, V. | Aging Clin Exp Res | 2023 |
Humans, Aged, Delirium/diagnosis/therapy, Clinical Competence, Surveys and Questionnaires, Anesthetics, Nurses, Delirium care practice, Delirium education, Delirium risk factors, Post-anaesthesia care units, Postoperative delirium, Registered nurses |
| Feasibility randomised controlled trial of online group Acceptance and Commitment Therapy for Functional Cognitive Disorder (ACT4FCD) | Poole, N. Cope, S. Vanzan, S. Duffus, A. Mantovani, N. Smith, J. Barrett, B. M. Tokley, M. Scicluna, M. Beardmore, S. Turner, K. Edwards, M. Howard, R. | BMJ Open | 2023 |
Humans, Acceptance and Commitment Therapy, Quality of Life, Feasibility Studies, Cognitive Dysfunction, Outcome Assessment, Health Care, Delirium & cognitive disorders, Neurology, Psychiatry |
| Factors Associated With Function-Focused Care Among Hospitalized Older Adults Living With Dementia | Resnick, B. Boltz, M. Galik, E. Kuzmik, A. Drazich, B. F. McPherson, R. Wells, C. L. Renn, C. Dorsey, S. G. Ellis, J. | Crit Care Nurs Q | 2023 |
Humans, Aged, Pain, Pain Management, Dementia/therapy, Delirium/epidemiology/therapy |
| Safety and Efficacy of BCMA CAR-T Cell Therapy in Older Patients With Multiple Myeloma | Reyes, K. R. Huang, C. Y. Lo, M. Arora, S. Chung, A. Wong, S. W. Wolf, J. Olin, R. L. Martin, T. Shah, N. Banerjee, R. | Transplant Cell Ther | 2023 |
Humans, Aged, Adult, Middle Aged, Multiple Myeloma/therapy, Receptors, Chimeric, Antigen/therapeutic use, B-Cell Maturation Antigen, Retrospective Studies, Agammaglobulinemia, Cell- and Tissue-Based Therapy, Delirium, CAR-T therapy, Elderly, Geriatric, Multiple myeloma |
| Low Skeletal Muscle Mass and the Incidence of Delirium in Hospitalized Older Patients: A Systematic Review and Meta-Analysis of Observational Studies | Shen, Y. Wan, Q. Zhao, R. Chen, Y. Xia, L. Wu, Y. Xiao, S. Wang, Y. Zhao, L. Li, T. Wu, X. | Int J Clin Pract | 2023 |
Humans, Risk Factors, Delirium/epidemiology/etiology, Incidence, Odds Ratio, Muscle, Skeletal |
| Intraoperative 5-HT(3) receptor antagonists decrease the prevalence of postoperative delirium in older adults undergoing hip fracture surgery: a single-center retrospective study | Shin, H. J. Park, J. I. Lee, S. Hwang, J. W. Na, H. S. | J Anesth | 2023 |
Humans, Male, Aged, Emergence Delirium/complications, Retrospective Studies, Serotonin, Palonosetron, Prevalence, Delirium/epidemiology/etiology/prevention & control, Hip Fractures/surgery, Risk Factors, Postoperative Complications/epidemiology/prevention & control, 5-HT3 receptor antagonist, Hip fracture, Older adults, Postoperative delirium, Ramosetron |
| Correlation of C-reactive Protein with Delirium in Obstetrics Intensive Care Unit: A Tertiary Center Experience | Shyam, R. Patel, M. L. Solanki, M. Sachan, R. Ali, W. | Indian J Crit Care Med | 2023 |
C-reactive protein, Critically ill, Delirium, Intensive Care Unit, Obstetric intensive care unit |
| Identification through the Manchester Triage System of the older population at risk of delirium: A case-control study | Soler-Sanchis, A. Martínez-Arnau, F. M. Sánchez-Frutos, J. Pérez-Ros, P. | J Clin Nurs | 2023 |
Humans, Aged, Aged, 80 and over, Triage, Case-Control Studies, Delirium/diagnosis/epidemiology, Emergency Service, Hospital, Risk Factors, Stroke, Dementia/diagnosis/epidemiology, Delirium, emergency department |
| Delusions and Hallucinations Are Associated With Greater Severity of Delirium | Trzepacz, P. T. Franco, J. G. Meagher, D. Kishi, Y. Sepúlveda, E. Gaviria, A. M. Chen, C. H. Huang, M. C. Furlanetto, L. M. Negreiros, D. Lee, Y. Kim, J. L. Kean, J. | J Acad Consult Liaison Psychiatry | 2023 |
Adult |
| Extremes of baseline cognitive function determine the severity of delirium: a population study | Tsui, A. Yeo, N. Searle, S. D. Bowden, H. Hoffmann, K. Hornby, J. Goslett, A. Weston-Clarke, M. Lanham, D. Hogan, P. Seeley, A. Rawle, M. Chaturvedi, N. Sampson, E. L. Rockwood, K. Cunningham, C. Ely, E. W. Richardson, S. J. Brayne, C. Terrera, G. M. Tieg | Brain | 2023 |
Humans, Delirium/epidemiology, Prospective Studies, Cognition, Research Design, baseline cognitive function, delirium, epidemiology |
| Differences in long-term outcomes between ICU patients with persistent delirium, non-persistent delirium and no delirium: A longitudinal cohort study | van der Heijden, E. F. M. Kooken, R. W. J. Zegers, M. Simons, K. S. van den Boogaard, M. | J Crit Care | 2023 |
Adult, Humans, Longitudinal Studies, Quality of Life, Intensive Care Units, Prospective Studies, Cohort Studies, Cognitive dysfunction, Critical illness, Delirium, Intensive care units, Outcome assessment, Patient reported outcome measures |
| Postoperative Delirium and Cognitive Dysfunction after General and Regional Anesthesia: A Systematic Review and Meta-Analysis | Viderman, D. Nabidollayeva, F. Aubakirova, M. Yessimova, D. Badenes, R. Abdildin, Y. | J Clin Med | 2023 |
general anesthesia, post-operative cognitive dysfunction, post-operative delirium, regional anesthesia |
| Deficient vitamin B12 levels are associated with increased delirium incidence in critically ill patients | Vosouqi, M. Abbasi, S. Farsaei, S. | Clin Nutr ESPEN | 2023 |
Adult, Humans, Delirium/epidemiology, Prospective Studies, Intensive Care Units, Critical Illness, Incidence, Cross-Sectional Studies, Cobalamin, Critical care, Delirium, Vitamin B 12 |
| Association of insulin resistance with delirium and CSF biomarkers of Alzheimer's disease in elderly patients with hip fracture | Wang, J. Shuang, P. Li, Z. Zhao, L. Wang, X. Liu, P. | Aging Clin Exp Res | 2023 |
Alzheimer’s disease, CSF biomarkers, Delirium, Dementia, Hip fracture, Insulin resistance |
| Family Presence May Reduce Postoperative Delirium After Spinal Surgery | Welsch, E. Vashisht, A. Stutzman, S. E. Olson, D. M. | J Neurosci Nurs | 2023 |
Humans, Delirium/prevention & control, Emergence Delirium, Prospective Studies, Intensive Care Units, Hospitalization |
| Delirium education for family caregivers of patients in the intensive care unit: A pilot study | Wheeler, A. Bloch, E. Blaylock, S. Root, J. Ibanez, K. Newman, K. Diarte, J. Voigt, L. P. | PEC Innov | 2023 |
Caregiver delirium education, Caregiver training, ICU delirium |
| Effect of internal jugular vein catheterization on intracranial pressure and postoperative cognitive function in patients undergoing robot-assisted laparoscopic surgery | Yang, B. Li, M. Liang, J. Tang, X. Chen, Q. | Front Med (Lausanne) | 2023 |
catheterization, internal jugular vein, optic nerve sheath diameter, postoperative delirium, robot-assisted laparoscopy |
| The association between gut microbiota and postoperative delirium in patients | Zhang, Y. Baldyga, K. Dong, Y. Song, W. Villanueva, M. Deng, H. Mueller, A. Houle, T. T. Marcantonio, E. R. Xie, Z. | J Clin Nurs | 2023 |
attitude, cardiac surgery, knowledge, postoperative delirium, practice |
| Knowledge, attitude, and practice regarding postoperative delirium among cardiac surgery nurses: A cross-sectional multi-centre study | Zhou, C. Qu, X. Wang, L. Wu, Q. Zhou, Y. | J Clin Nurs | 2023 |
attitude, cardiac surgery, knowledge, postoperative delirium, practice |
| Incidence and risk factors of postoperative delirium after pancreatic cancer surgery: a retrospective study | Zhao, B. Ji, H. S. Xu, C. Y. Li, D. J. Xing, Z. Q. Liu, B. Han, Y. Xia, W. J. Han, L. H. | Surg Today | 2023 |
Humans, Retrospective Studies, *Emergence Delirium, Postoperative, Complications/epidemiology/etiology, Incidence, Risk Factors, *Pancreatic Neoplasms/surgery/complications, Pancreatic cancer, Postoperative delirium |
| Silent Brain Infarction, Delirium, and Cognition in Three Invasive Cardiovascular Procedures: a Systematic Review | Gerstenecker, A. Norling, A. M. Jacob, A. Lazar, R. M. | Neuropsychol Rev | 2023 |
Humans, Brain Infarction/complications, Coronary Artery Bypass/adverse effects, *Transcatheter Aortic Valve Replacement/adverse effects, Cognition Risk Factors, *Delirium/etiology/diagnosis/psychology, Af, Cabg, Delirium, Silent brain infarction, Tavr |
| Feasibility of Light and Music Therapy in the Elderly for the Prevention of Hospital-Associated Delirium | Keene, S. Balasundaram, A. Cameron-Comasco, L. Otero, R. | R I Med J (2013) | 2023 |
Aged, Humans, *Delirium/prevention & control, *Music Therapy, Feasibility Studies, Pilot Projects, Hospitals, Emergency Service, Hospital, delirium, dementia, emergency department, geriatrics, quality improvement |
| Identification of risk factors for postoperative delirium in patients following intraoral reconstruction with microvascular free flaps: a matched-pair analysis | Ooms, M. Schooß, R. Puladi, B. Steiner, T. Hölzle, F. Bickenbach, J. Rieg, A. Modabber, A. | Int J Oral Maxillofac Surg | 2023 |
Delirium, Free tissue flaps, Matched-pair analysis, Oral surgical procedures, Risk factors |
| Challenges in diagnosis and management of delirium in Lewy body disease | Richardson, S. Lawson, R. A. Price, A. Taylor, J. P. | Acta Psychiatr Scand | 2023 |
Humans, *Lewy Body Disease/therapy/drug therapy,*Dementia, *Parkinson Disease/complications/diagnosis, *Alzheimer Disease, Hallucinations, *Delirium/diagnosis/etiology/therapy, delirium, dementia, lewy |
| Frequency of delirium and its associated factors among COVID-19 inpatients in Iran | Alizadeh Arimi, F. Zarghami, M. Moosazadeh, M. Mehravaran, H. Sedighi, F. Ghasemian, R. Elyasi, F. | Clin Respir J | 2023 |
Covid-19, clinical, delirium, demographic factors, hospital |
| Improving Nurses Knowledge and Practices of Delirium Assessment at Mbarara Regional Referral Hospital: A Quasi Experimental Study | Baluku Murungi, E. Niyonzima, V. Atuhaire, E. Nantume, S. Beebwa, E. | Adv Med Educ Pract | 2023 |
Cam-icu, assessment, delirium, knowledge, nurse, practice, research |
| Sex differences in clinical outcomes amongst 1105 patients admitted with hip fractures | Fluck, D. Lisk, R. Yeong, K. Mahmood, R. Robin, J. Fry, C. H. Han, T. S. | Intern Emerg Med | 2023 |
Delirium, Healthcare, Length of stay, Mortality, Nursing care |
| The Effect of Peripheral Nerve Block on Postoperative Delirium in Older Adults Undergoing Hip Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Kim, S. Y. Jo, H. Y. Na, H. S. Han, S. H. Do, S. H. Shin, H. J. | J Clin Med | 2023 |
elderly, hip surgery, meta-analysis, peripheral nerve blocks, postoperative delirium |
| Effect of Different Administration Routes of Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Elective Spinal Surgery: A Prospective Randomized Double-Blinded Controlled Trial | Niu, J. Y. Yang, N. Tao, Q. Y. He, Y. Hou, Y. B. Ning, R. D. Yu, J. M. | Anesth Analg | 2023 |
intravenous dexmedetomidine, postoperative delirium, aged, administration route, anesthesia, intratracheal dexmedetomidine |
| Electroconvulsive therapy plus lithium is associated with less cognitive impairment and drug-induced delirium in bipolar depression compared to unipolar depression | Youssef, N. A. Madangarli, N. Bachu, A. Patel, R. S. | Ann Clin Psychiatry | 2023 |
Adult, Humans, *Bipolar Disorder/drug therapy/psychology, *Electroconvulsive Therapy/adverse effects, *Depressive Disorder, Major/drug therapy, Lithium/therapeutic use, *Delirium/chemically induced/epidemiology, *Cognitive Dysfunction/chemically induced/epidemiology, Treatment Outcome |
| Pharmacologic Management of Intensive Care Unit Delirium and the Impact on the Duration of Delirium, Length of Intensive Care Unit Stay and 30-Day Mortality: A Network Meta-Analysis of Randomized-Control Trials | Afzal, M. S. Atunde, F. J. Yousaf, R. A. Ali, S. Nasir, N. Medarametla, G. D. Muhammad, N. Amin, A. | Cureus | 2023 |
atypical antipsychotic, dementia, icu, meta-analysis, typical antipsychotic |
| Delirium incidence, predictors and outcomes in the intensive care unit: A prospective cohort study | Alzoubi, E. Shaheen, F. Yousef, K. | Int J Nurs Pract | 2023 |
delirium, intensive care unit, mortality, nursing, prediction |
| A Cross-Sectional, Retrospective, and Comparative Study between Delirium and Non-Delirium Psychiatric Disorders in a Psychogeriatric Inpatient Population Referred to Consultation-Liaison Psychiatry Unit | Barra, B. J. Barahona, M. Varela, L. F. Calvo, P. Bastidas, A. Carreño, J. Pintor, L. | Medicina (Kaunas) | 2023 |
Humans, Aged, Retrospective Studies, Geriatric Psychiatry, Inpatients, Cross-Sectional Studies, *Mental Disorders/diagnosis, *Psychiatry, Referral and, Consultation, consultation-liaison psychiatry, delirium, inpatient, psychosomatic medicine |
| Potential Risk Factors for, and Clinical Implications of, Delirium during Inpatient Rehabilitation: A Matched Case-Control Study | Ceppi, M. G. Rauch, M. S. Spöndlin, J. Gantenbein, A. R. Meier, C. R. Sándor, P. S. | J Am Med Dir Assoc | 2023 |
Humans, *Inpatients, Case-Control Studies, Hospitalization, Risk Factors, *Delirium/epidemiology, Delirium, case-control study, inpatient rehabilitation |
| Using the Electronic Health Record to Support Implementation of Emergency Department Delirium Screening: A Qualitative Study | Chary, A. Brickhouse, E. Torres, B. Santangelo, I. Carpenter, C. R. Liu, S. W. Godwin, K. M. Naik, A. D. Singh, H. Kennedy, M. | Appl Clin Inform | 2023 |
emergency department, electronic health record, delirium, delirium screening, health information technology |
| Predicting postoperative delirium after hip arthroplasty for elderly patients using machine learning | Chen, D. Wang, W. Wang, S. Tan, M. Su, S. Wu, J. Yang, J. Li, Q. Tang, Y. Cao, J. | Aging Clin Exp Res | 2023 |
Elderly patients, Hip arthroplasty, Machine learning, Perioperative neurocognitive disorders, Postoperative delirium |
| Is a hyperosmolar pump prime for cardiopulmonary bypass a risk factor for postoperative delirium? A double blinded randomised controlled trial | Claesson Lingehall, H. Gustafson, Y. Svenmarker, S. Appelblad, M. Davidsson, F. Holmner, F. Wahba, A. Olofsson, B. | Scand Cardiovasc J | 2023 |
Humans, *Emergence Delirium/complications, Cardiopulmonary Bypass/adverse effects, Prospective Studies, Mannitol/adverse effects, Risk Factors, Postoperative Complications/diagnosis/etiology, Cardiac surgery, cardiopulmonary bypass, delirium, mannitol, osmolality |
| A long duration of intraoperative hypotension is associated with postoperative delirium occurrence following thoracic and orthopedic surgery in elderly | Duan, W. Zhou, C. M. Yang, J. J. Zhang, Y. Li, Z. P. Ma, D. Q. Yang, J. J. | J Clin Anesth | 2023 |
Anesthesia, Elderly, Intraoperative hypotension, Postoperative delirium, thoracic surgery, orthopedic surgery |
| Does improving sleep for the critically ill reduce the incidence and duration of delirium? An evidence-based review | Elliott, R. Delaney, L. | Nurs Crit Care | 2023 |
critical illness, delirium, sleep, review, MESH |
| Delirium Mediates Incidence of Hospital-Associated Disability Among Older Adults | Freeman, H. Martin, R. C. Whittington, C. Zhang, Y. Osborne, J. D. O'Leary, T. Vickers, J. K. Flood, K. L. Skains, R. M. Markland, A. D. Buford, T. W. Brown, C. J. Kennedy, R. E. | J Am Med Dir Assoc | 2023 |
Humans, Aged, *Delirium/diagnosis, Activities of Daily Living, Retrospective Studies, Incidence, Cross-Sectional Studies, Risk Factors, Prospective Studies, Hospitalization, Hospitals, *Dementia/diagnosis, Delirium, cognition, disability, functional impairment |
| Dysphagia in older patients admitted to a rehabilitation setting after an acute hospitalization: the role of delirium | Grossi, E. Rocco, C. Stilo, L. Guarneri, B. Inzitari, M. Bellelli, G. Gentile, S. Morandi, A. | Eur Geriatr Med | 2023 |
Delirium, Dysphagia, Malnutrition, Swallowing |
| Transcutaneous Electrical Acupoint Stimulation for Preventing Postoperative Delirium: A Meta-Analysis | Guo, F. Yan, Y. Sun, L. Han, R. Zheng, L. Qin, Y. Wang, S. Sun, X. Ji, Z. Gao, C. | Neuropsychiatr Dis Treat | 2023 |
Pod, Teas, meta-analysis, postoperative delirium, transcutaneous electrical acupoint stimulation |
| Delirium Following Anticholinergic Use in Hospitalized Patients With Dementia | Hale, E. W. Macchi, Z. A. Pressman, P. S. | Neurohospitalist | 2023 |
anticholinergics, delirium, dementia, hospitalized, retrospective studies |
| The Association Between Enhanced Recovery After Cardiac Surgery-Guided Analgesics and Postoperative Delirium | Jelly, C. A. Clifton, J. C. Billings, F. T. th Hernandez, A. Schaffer, A. J. Shotwell, M. E. Freundlich, R. E. | J Cardiothorac Vasc Anesth | 2023 |
Adult, Humans, Acetaminophen, Analgesics, Opioid/adverse effects, *Emergence Delirium/diagnosis/epidemiology/prevention & control, *Dexmedetomidine, Gabapentin, *Ketamine, Pain, Postoperative/diagnosis/drug therapy/prevention & control, Analgesics, *Cardiac Surgical Procedures/adverse effects, Lidocaine, Enhanced Recovery After Cardiac Surgery (ERACS), cardiac delirium, multimodal analgesia, pain |
| Association between intraoperative body temperature and postoperative delirium: A retrospective observational study | Ju, J. W. Nam, K. Sohn, J. Y. Joo, S. Lee, J. Lee, S. Cho, Y. J. Jeon, Y. | J Clin Anesth | 2023 |
Adult, Humans, Body Temperature, *Hypothermia/etiology/complications, *Emergence Delirium, Retrospective Studies, Regression Analysis, Postoperative Complications/epidemiology/etiology, Delirium, Hypothermia, Noncardiac surgery, Prevention |
| Association between Preoperative Hand Grip Strength and Postoperative Delirium after Cardiovascular Surgery: A Retrospective Study | Kotani, T. Ida, M. Inoue, S. Naito, Y. Kawaguchi, M. | J Clin Med | 2023 |
cardiovascular surgical procedures, delirium, hand strength, postoperative cognitive complications, postoperative period |
| Plasma HMGB1 levels in postoperative delirium | Kunkel, D. Parker, M. Pearce, R. A. Sanders, R. D. Lennertz, R. C. | Br J Anaesth | 2023 |
Humans, *Emergence Delirium, *HMGB1 Protein, *Cognition Disorders, *Cognitive Dysfunction, Postoperative Complications, damage-associated, molecular patterns, delirium, high mobility group box protein 1, perioperative, neurocognitive disorders, postoperative cognitive dysfunction, surgery |
| Sleep Loss the night before surgery and incidence of postoperative delirium in adults 65-95 years of age | Leung, J. M. Tang, C. Do, Q. Sands, L. P. Tran, D. Lee, K. A. | Sleep Med | 2023 |
Humans, Adult, Aged, Aged, 80 and over, *Emergence, Delirium/epidemiology/complications, *Delirium/epidemiology/etiology, Postoperative Complications/epidemiology/etiology, Prospective Studies, Incidence, *Sleep Initiation and Maintenance Disorders/complications, Sleep, Risk Factors, Actigraphy, Postoperative delirium, Preoperative sleep disruption, Surgery |
| The effects of a sensory stimulation intervention for preventing delirium in a surgical intensive care unit: A randomized controlled trial | Liang, S. Chau, J. P. C. Lo, S. H. S. Choi, K. C. Bai, L. Cai, W. | Nurs Crit Care | 2023 |
confusion assessment method for the intensive care unit, delirium, intensive care unit, randomized controlled trial, sensory stimulation |
| Developing and validating a machine learning ensemble model to predict postoperative delirium in a cohort of high-risk surgical patients: A secondary cohort analysis | Neto, P. C. S. Rodrigues, A. L. Stahlschmidt, A. Helal, L. Stefani, L. C. | Eur J Anaesthesiol | 2023 |
Humans, *Emergence Delirium, *Delirium/diagnosis/epidemiology/etiology, Risk Factors, Cohort Studies, Postoperative Complications/diagnosis/epidemiology/etiology, Machine Learning, Retrospective Studies |