What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Prevention of dexmedetomidine on postoperative delirium and early postoperative cognitive dysfunction in elderly patients undergoing hepatic lobectomy
- Authors
- Tang, Y. Wang, Y. Kong, G. Zhao, Y. Wei, L. Liu, J.
- Year
- 2022
- Journal
- Zhong Nan Da Xue Xue Bao Yi Xue Ban
- Abstract
OBJECTIVES: Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are common operative neurocognitive disorders, which places a heavy burden on patients, families and society. Therefore, it is very important to search for preventive drugs. Previous studies have demonstrated that perioperative use of dexmedetomidine resulted in a decrease the incidence of POD and POCD. But the specific effect of dexmedetomidine on elderly patients undergoing hepatic lobectomy and its potential mechanism are not clear. This study aims to evaluate the efficacy of intraoperative use of dexmedetomidine on preventing POD and POCD in elderly patients undergoing hepatic lobectomy and the influence on the balance between proinflammation and anti-inflammation. METHODS: This trial was designed as a single-center, prospective, randomized, controlled study. One hundred and twenty hospitalized patients from January 2019 to December 2020, aged 60-80 years old with American Society of Anesthesiologists (ASA) II-III and scheduled for hepatic lobectomy, were randomly allocated into 3 groups (n=40) using a random number table: A C group, a Dex1 group, and a Dex2 group. After anesthesia induction, saline in the C group, dexmedetomidine [0.3 μg/(kg·h)] in the Dex1 group, and dexmedetomidine [0.6 μg/(kg·h)] in the Dex2 group were infused until the end of operation. The incidences of hypotension and bradycardia were compared among the 3 groups. Confusion Assessment Method (CAM) for assessing POD and Mini Mental State Examination (MMSE) for evaluating POCD were recorded and venous blood samples were obtained for the determination of neuron specific enolase (NSE), TNF-α, IL-1β, and IL-10 at the different time below: the time before anesthesia (T0), and the first day (T1), the third day (T2), the fifth day (T3), and the seventh day (T4) after operation. RESULTS: Compared with the C group, the incidences of bradycardia in the Dex1 group or the Dex2 group increased (both P<0.05) and there was no difference in hypotension in the Dex1 group or the Dex2 group (both P>0.05). The incidences of POD in the C group, the Dex1 group, and the Dex2 group were 22.5%, 5.0%, and 7.5%, respectively. The incidences of POD in the Dex1 group or the Dex2 group declined significantly as compared to the C group (both P<0.05). However, there is no difference in the incidence of POD between the Dex1 group and the Dex2 group (P>0.05). The incidences of POCD in the C group, the Dex1 group, and the Dex2 group were 30.0%, 12.5%, and 10.0%, respectively. The incidences of POCD in the Dex1 group and the Dex2 group declined significantly as compared to the C group (both P<0.05). And no obvious difference was seen in the incidence of POCD in the Dex1 group and the Dex2 group (P>0.05). Compared with the C group, the level of TNF-α and IL-1β decreased and the level of IL-10 increased at each time points (from T1 to T4) in the Dex1 group and the Dex2 group (all P<0.05). Compared with the Dex1 group, the level of IL-1β at T2 and IL-10 from T1 to T3 elevated in the Dex2 group (all P<0.05). Compared with the T0, the concentrations of NSE in C group at each time points (from T1 to T4) and in the Dex1 group and the Dex2 group from T1 to T3 increased (all P<0.05). Compared with the C group, the level of NSE decreased from T1 to T4 in the Dex1 group and the Dex2 group (all P<0.05). CONCLUSIONS: Intraoperative dexmedetomidine infusion can reduce the incidence of POCD and POD in elderly patients undergoing hepatic lobectomy, and the protective mechanism appears to involve the down-regulation of TNF-α and IL-1β and upregulation of IL-10 expression, which lead to rebalance between proinflammation and anti-inflammation.
- PMID
- Keywords
Aged
Aged, 80 and over
Bradycardia
*Cognitive Dysfunction/etiology/prevention & control
*Delirium/drug therapy/epidemiology/prevention & control
*Dexmedetomidine/therapeutic use
Humans
*Hypotension/complications/drug therapy
Interleukin-10
Middle Aged
*Postoperative Cognitive Complications/prevention & control
Postoperative Complications/epidemiology
Prospective Studies
Tumor Necrosis Factor-alpha
dexmedetomidine
elderly patients
hepatic lobectomy
postoperative cognitive dysfunction
postoperative delirium
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Delirium Monitoring in Neurocritically Ill Patients: A Systematic Review. | Patel, M. B. Bednarik, J. Lee, P. Shehabi, Y. Salluh, J. I. Slooter, A. J. Klein, K. E. Skrobik, Y. Morandi, A. Spronk, P. E. Naidech, A. M. Pun, B. T. Bozza, F. A. Marra, A. John, S. Pandharipande, P. P. Ely, E. W. | Crit Care Med | 2018 | |
| Poststroke Delirium Clinical Motor Subtypes: The PRospective Observational POLIsh Study (PROPOLIS). | Pasinska, P. Kowalska, K. Klimiec, E. Wilk, A. Szyper-Maciejowska, A. Dziedzic, T. Klimkowicz-Mrowiec, A. | J Neuropsychiatry Clin Neurosci | 2018 |
Delirium |
| A systematic review of neuroimaging in delirium: predictors, correlates and consequences. | Nitchingham A, Kumar V, Shenkin S, Ferguson KJ, Caplan GA | International journal of geriatric psychiatry | 2017 |
delirium |
| The effect of dexmedetomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis. | Ng, K. T. Shubash, C. J. Chong, J. S. | Anaesthesia | 2018 |
adult |
| A Point Prevalence Study of Delirium in Italian Nursing Homes. | Morichi, V. Fedecostante, M. Morandi, A. Di Santo, S. G. Mazzone, A. Mossello, E. Bo, M. Bianchetti, A. Rozzini, R. Zanetti, E. Musicco, M. Ferrari, A. Ferrara, N. Trabucchi, M. Cherubini, A. Bellelli, G. | Dementia and Geriatric Cognitive Disorders | 2018 |
neuroleptic agent |
| Increased Readmission Risk and Healthcare Cost for Delirium Patients without Immediate Hospitalization in the Emergency Department. | Ma, I. C. Chen, K. C. Chen, W. T. Tsai, H. C. Su, C. C. Lu, R. B. Chen, P. S. Chang, W. H. Yang, Y. K. | Clin Psychopharmacol Neurosci | 2018 |
Delirium |
| The effect of chronotherapy on delirium in critical care - a systematic review. | Luther R, McLeod A | Nursing in critical care | 2017 |
Adult intensive care |
| Postoperative Complications Associated With Spine Surgery in Patients Older Than 90 Years: A Multicenter Retrospective Study. | Kobayashi, K. Imagama, S. Sato, K. Kato, F. Kanemura, T. Yoshihara, H. Sakai, Y. Shinjo, R. Hachiya, Y. Osawa, Y. Matsubara, Y. Ando, K. Nishida, Y. Ishiguro, N. | Global Spine J | 2018 |
complications |
| Do the Phenotypes of Symptom Fluctuation Differ Among Motor Subtypes in Patients With Delirium?. | Kim, S. Y. Kim, J. M. Kim, S. W. Kim, E. S. Kang, H. J. Lee, J. Y. Bae, K. Y. Shin, I. S. Yoon, J. S. | J Pain Symptom Manage | 2018 |
Delirium |
| Delirium and its consequences in the specialized palliative care unit: Validation of the Korean version of Memorial Delirium Assessment Scale. | Kang, B. Kim, Y. J. Suh, S. W. Son, K. L. Ahn, G. S. Park, H. Y. | Psycho-Oncology | 2018 |
adult |
| The Motoric Types of Delirium and Estimated Blood Loss during Perioperative Period in Orthopedic Elderly Patients. | Hong, N. Park, J. Y. | Biomed Res Int | 2018 | |
| CSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers Abeta42, t-tau and p-tau. | Henjum, K. Quist-Paulsen, E. Zetterberg, H. Blennow, K. Nilsson, L. N. G. Watne, L. O. | J Neuroinflammation | 2018 |
Alzheimer’s disease |
| CSF biomarkers in delirium: a systematic review. | Hall RJ, Watne LO, Cunningham E, Zetterberg H, Shenkin SD, Wyller TB, MacLullich AMJ | International journal of geriatric psychiatry | 2017 |
CSF biomarkers |
| Prediction of ICU Delirium: Validation of Current Delirium Predictive Models in Routine Clinical Practice. | Green, C. Bonavia, W. Toh, C. Tiruvoipati, R. | Crit Care Med | 2018 | |
| The Incidence of Recorded Delirium Episodes Before and After Dementia Diagnosis: Differences Between Dementia With Lewy Bodies and Alzheimer's Disease. | FitzGerald, J. M. Perera, G. Chang-Tave, A. Price, A. Rajkumar, A. P. Bhattarai, M. O'Brien, J. T. Ballard, C. Aarsland, D. Stewart, R. Mueller, C. | J Am Med Dir Assoc | 2018 |
Alzheimer’s disease |
| Pain and delirium in people with dementia in the acute general hospital setting. | Feast, A. R. White, N. Lord, K. Kupeli, N. Vickerstaff, V. Sampson, E. L. | Age Ageing | 2018 | |
| Environmental factors and risk of delirium in geriatric patients: an observational study. | Evensen, S. Saltvedt, I. Lydersen, S. Wyller, T. B. Taraldsen, K. Sletvold, O. | BMC Geriatr | 2018 |
Delirium |
| Validity of a screening method for delirium risk in older patients admitted to a general hospital in the Netherlands. | Ettema, R. Heim, N. Hamaker, M. Emmelot-Vonk, M. van der Mast, R. Schuurmans, M. | General Hospital Psychiatry | 2018 |
aged |
| Indwelling urinary catheters, aortic valve treatment and delirium: a prospective cohort study. | Eide, L. S. Ranhoff, A. H. Lauck, S. Fridlund, B. Haaverstad, R. Hufthammer, K. O. Kuiper, K. K. J. Nordrehaug, J. E. Norekval, T. M. | BMJ Open | 2018 |
Savr |
| Diagnostic value of NT-proCNP compared to NSE and S100B in cerebrospinal fluid and plasma of patients with sepsis-associated encephalopathy. | Ehler, J. Saller, T. Wittstock, M. Rommer, P. S. Chappell, D. Zwissler, B. Grossmann, A. Richter, G. Reuter, D. A. Noldge-Schomburg, G. Sauer, M. | Neurosci Lett | 2018 |
Biomarker |
| Exploration of Relationships Between Postoperative Pain and Subsyndromal Delirium in Older Adults. | Denny, D. L. Such, T. L. | Nurs Res | 2018 | |
| Prediction of Incident Delirium Using a Random Forest classifier. | Corradi, J. P. Thompson, S. Mather, J. F. Waszynski, C. M. Dicks, R. S. | J Med Syst | 2018 |
Decision support |
| The hip fracture surgery in elderly patients (HIPELD) study to evaluate xenon anaesthesia for the prevention of postoperative delirium: a multicentre, randomized clinical trial. | Coburn, M. Sanders, R. D. Maze, M. Nguyên-Pascal, M. L. Rex, S. Garrigues, B. Carbonell, J. A. Garcia-Perez, M. L. Stevanovic, A. Kienbaum, P. Neukirchen, M. Schaefer, M. S. Borghi, B. van Oven, H. Tognù, A. Al Tmimi, L. Eyrolle, L. Langeron, O. Capdevi | British Journal of Anaesthesia | 2018 |
C reactive protein |
| Effect of a single pre-operative 125 mg dose of methylprednisolone on postoperative delirium in hip fracture patients; a randomised, double-blind, placebo-controlled trial. | Clemmesen, C. G. Lunn, T. H. Kristensen, M. T. Palm, H. Foss, N. B. | Anaesthesia | 2018 |
delirium |
| Identifying Patterns of Delirium in Hospitalized Patients on Dexamethasone Using a Chart Abstraction Tool. | Chang, J. T. Atayee, R. S. Edmonds, K. P. | Journal of Pain and Palliative Care Pharmacotherapy | 2018 |
dexamethasone |
| Detecting delirium in elderly medical emergency patients: validation and subsequent modification of the German Nursing Delirium Screening Scale. | Brich, J. Baten, V. Wussmann, J. Heupel-Reuter, M. Perlov, E. Kloppel, S. Busch, H. J. | Intern Emerg Med | 2018 |
Delirium |
| Mobilizing older adults: A multi-site, exploratory and observational study on patients enrolled in the Hospital Elder Life Program (HELP). | Babine, R. L. Hyrkas, K. E. McKenzie, C. G. Wierman, H. R. | Geriatr Nurs | 2018 |
Older adults |
| Validation of the Stanford Proxy Test for Delirium (S-PTD) among critical and noncritical patients. | Alosaimi, F. D. Alghamdi, A. Alsuhaibani, R. Alhammad, G. Albatili, A. Albatly, L. Althomali, B. Aljamaan, F. Maldonado, J. R. | J Psychosom Res | 2018 |
Delirium |
| Impact of an Antipsychotic Discontinuation Bundle During Transitions of Care in Critically Ill Patients. | D’Angelo, R. G. Rincavage, M. Tata, A. L. Millstein, L. S. Gulati, M. S. Flurie, R. W. Gonzales, J. P. | J Intensive Care Med | 2019 |
urinary catheter |
| Living at home after emergency hospital admission: Prospective cohort study in older adults with and without cognitive spectrum disorder. | Burton, J. K. Guthrie, B. Hapca, S. M. Cvoro, V. Donnan, P. T. Reynish, E. L. | BMC Medicine | 2018 |
aged |
| The Association Between C-Reactive Protein and Postoperative Delirium Differs by Catechol-O-Methyltransferase Genotype. | Vasunilashorn, S. M. Ngo, L. H. Jones, R. N. Inouye, S. K. Hall, K. T. Gallagher, J. Dillon, S. T. Xie, Z. Libermann, T. A. Marcantonio, E. R. | American Journal of Geriatric Psychiatry | 2019 |
acute phase protein |
| Risk factors associated with acute in-hospital delirium for patients diagnosed with a hip fracture in the emergency department. | Thompson, C. Brienza, V. J. M. Sandre, A. Caine, S. Borgundvaag, B. McLeod, S. | Canadian Journal of Emergency Medicine | 2018 |
codeine |
| A Comparison of Early, Late, and No Treatment of Intensive Care Unit Delirium With Antipsychotics: A Retrospective Cohort Study. | Thom, R. P. Bui, M. P. Rosner, B. Teslyar, P. Levy-Carrick, N. C. Klompas, M. | The Primary Care Companion for CNS Disorders | 2018 |
neuroleptic agent |
| Postoperative Pain Management Strategies and Delirium After Transapical Aortic Valve Replacement: A Randomized Controlled Trial. | Strike, E. Arklina, B. Stradins, P. Cusimano, R. J. Osten, M. Horlick, E. Styra, R. Poonawala, H. Carroll, J. Djaiani, G. | Journal of Cardiothoracic and Vascular Anesthesia | 2018 |
adult |
| Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium: The STRIDE Randomized Clinical Trial. | Sieber, F. E. Neufeld, K. J. Gottschalk, A. Bigelow, G. E. Oh, E. S. Rosenberg, P. B. Mears, S. C. Stewart, K. J. Ouanes, J. P. P. Jaberi, M. Hasenboehler, E. A. Li, T. Wang, N. Y. | JAMA Surg | 2018 |
local anesthetic agent |
| Incidence of Delirium in Critically Ill Cancer Patients. | Sánchez-Hurtado, L. A. Hernández-Sánchez, N. Del Moral-Armengol, M. Guevara-García, H. García-Guillén, F. J. Herrera-Gómez, Á Ñamendys-Silva, S. A. | Pain Research & Management | 2018 |
adult |
| Dispersion in Scores on the Richmond Agitation and Sedation Scale as a Measure of Delirium in Patients with Subdural Hematomas. | Robinson, D. Thompson, S. Bauerschmidt, A. Melmed, K. Couch, C. Park, S. Agarwal, S. Roh, D. Connolly, E. S. Claassen, J. | Neurocritical Care | 2018 |
adult |
| Underdiagnosis of delirium in the elderly in acute care hospital settings: lessons not learned. | Ritter, S. R. F. Cardoso, A. F. Lins, M. M. P. Zoccoli, T. L. V. Freitas, M. P. D. Camargos, E. F. | Psychogeriatrics | 2018 |
aged |
| Risk Factors and Hospital Mortality in Surgical and Non-surgical Patients with Delirium. | Restrepo, D. Duque, M. Montoya, L. Berrouet, M. C. Rojas, M. Lopera, G. Giraldo, K. | Revista Colombiana de Psiquiatria | 2018 |
cholinergic receptor blocking agent |
| Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults. | Pun, B. T. Balas, M. C. Barnes-Daly, M. A. Thompson, J. L. Aldrich, J. M. Barr, J. Byrum, D. Carson, S. S. Devlin, J. W. Engel, H. J. Esbrook, C. L. Hargett, K. D. Harmon, L. Hielsberg, C. Jackson, J. C. Kelly, T. L. Kumar, V. Millner, L. Morse, A. Perme, | Crit Care Med | 2019 |
adult |
| Effects of Perioperative Dexmedetomidine on Postoperative Mortality and Morbidity: A Systematic Review and Meta-analysis | Peng, K. Ji, F. H. Liu, H. Y. Zhang, J. Chen, Q. C. Jiang, Y. H. | Clinical Therapeutics | 2018 |
adult |
| Relation Between Delirium and Anticholinergic Drug Burden in a Cohort of Hospitalized Older Patients: An Observational Study. | Pasina, L. Colzani, L. Cortesi, L. Tettamanti, M. Zambon, A. Nobili, A. Mazzone, A. Mazzola, P. Annoni, G. Bellelli, G. | Drugs Aging | 2018 |
adverse event |
| Neopterin and mini-mental state examination scores, two independent risk factors for postoperative delirium in elderly patients with open abdominal surgery. | Miao, S. Shen, P. Zhang, Q. Wang, H. Shen, J. Wang, G. Lv, D. | Journal of Cancer Research and Therapeutics | 2018 |
C reactive protein |
| Reliability and accuracy of delirium assessments among investigators at multiple international centres. | Maybrier, H. R. Mickle, A. M. Escallier, K. E. Lin, N. Schmitt, E. M. Upadhyayula, R. T. Wildes, T. S. Mashour, G. A. Palihnich, K. Inouye, S. K. Avidan, M. S. | BMJ Open | 2018 |
NCT01690988 |
| Does the melatonin receptor 1B gene polymorphism have a role in postoperative delirium? | Mahanna-Gabrielli, E. Miano, T. A. Augoustides, J. G. Kim, C. Bavaria, J. E. Andrew Kofke, W. | PLoS ONE | 2018 |
adult |
| Volatile anaesthetics and postoperative delirium in older surgical patients—A secondary analysis of prospective cohort studies | Kinjo, S. Lim, E. Magsaysay, M. V. Sands, L. P. Leung, J. M. | Acta Anaesthesiol Scand | 2019 |
desflurane |
| Addition of Suvorexant to Ramelteon Therapy for Improved Sleep Quality with Reduced Delirium Risk in Acute Stroke Patients. | Kawada, K. Ohta, T. Tanaka, K. Miyamura, M. Tanaka, S. | Journal of Stroke and Cerebrovascular Diseases | 2019 |
phosphorus 33 |
| Age-dependent morbidity and mortality outcomes after surgical aortic valve replacement. | Hussain, A. I. Auensen, A. Brunborg, C. Beitnes, J. O. Gullestad, L. Pettersen, K. I. | Interactive cardiovascular and thoracic surgery | 2018 |
NCT01794832 |
| Interventions for preventing intensive care unit delirium in adults. | Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T. | Cochrane Database of Systematic Reviews | 2018 |
ISRCTN83567338 |
| Mortality in people with dementia, delirium, and unspecified cognitive impairment in the general hospital: Prospective cohort study of 6,724 patients with 2 years follow-up. | Hapca, S. Guthrie, B. Cvoro, V. Bu, F. Rutherford, A. C. Reynish, E. Donnan, P. T. | Clinical Epidemiology | 2018 |
aged |
| Neurofilament Light in the Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium. | Halaas, N. B. Blennow, K. Idland, A. V. Wyller, T. B. Ræder, J. Frihagen, F. Staff, A. C. Zetterberg, H. Watne, L. O. | Dementia and Geriatric Cognitive Disorders | 2018 |
aged |
| Investigating speech and language impairments in delirium: A preliminary case-control study. | Green, S. Reivonen, S. Rutter, L. M. Nouzova, E. Duncan, N. Clarke, C. MacLullich, A. M. J. Tieges, Z. | PLoS One | 2018 |
aged |
| Elevated serum S-100β in patients with septic shock is associated with delirium. | Erikson, K. Ala-Kokko, T. I. Koskenkari, J. Liisanantti, J. H. Kamakura, R. Herzig, K. H. Syrjälä, H. | Acta Anaesthesiol Scand | 2019 |
interleukin 6 |
| A prospective, observational study of cerebrovascular autoregulation and its association with delirium following cardiac surgery. | Chan, B. Aneman, A. | Anaesthesia | 2019 |
FORESIGHT Elite |
| Dynamic cerebral autoregulation: A marker of post-operative delirium? | Caldas, J. R. Panerai, R. B. Bor-Seng-Shu, E. Ferreira, G. S. R. Camara, L. Passos, R. H. de-Lima-Oliveira, M. Galas, F. R. B. G. Almeida, J. P. Nogueira, R. C. Mian, N. Gaiotto, F. A. Robinson, T. G. Hajjar, L. A. | Clinical Neurophysiology | 2018 |
NCT02143544 |
| The Golden Angels: Effects of trained volunteers on specialling and readmission rates for people with dementia and delirium in rural hospitals. | Blair, A. Anderson, K. Bateman, C. | International Psychogeriatrics | 2018 |
hearing aid |
| The effectiveness of non-pharmacological interventions in reducing the incidence and duration of delirium in critically ill patients: a systematic review and meta-analysis. | Bannon, L. McGaughey, J. Verghis, R. Clarke, M. McAuley, D. F. Blackwood, B. | Intensive Care Medicine | 2018 |
adult |
| Blood Thiamine Level and Cognitive Function in Older Hospitalized Patients. | Pourhassan, M. Angersbach, B. Lueg, G. Klimek, C. N. Wirth, R. | J Geriatr Psychiatry Neurol | 2018 |
delirium |
| Low doses of ketamine reduce delirium but not opiate consumption in mechanically ventilated and sedated ICU patients: A randomised double-blind control trial. | Perbet, S. Verdonk, F. Godet, T. Jabaudon, M. Chartier, C. Cayot, S. Guerin, R. Morand, D. Bazin, J. E. Futier, E. Pereira, B. Constantin, J. M. | Anaesth Crit Care Pain Med | 2018 |
Consumption of opiates |
| CSF sodium at toxic levels precedes delirium in hip fracture patients. | Hassel, B. Mariussen, E. Idland, A. V. Dahl, G. T. Raeder, J. Frihagen, F. Berg, J. P. Chaudhry, F. A. Wyller, T. B. Watne, L. O. | Neurotoxicology | 2018 |
Cerebrospinal fluid |
| Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation. | Zamami, Y. Kouno, Y. Niimura, T. Chuma, M. Imai, T. Mitsui, M. Koyama, T. Kayano, M. Okada, N. Hamano, H. Goda, M. Imanishi, M. Takechi, K. Horinouchi, Y. Kondo, Y. Yanagawa, H. Kitamura, Y. Sendo, T. Ujike, Y. Ishizawa, K. | Pharmazie | 2018 | |
| Prevalence and risk factors of delirium and subsyndromal delirium in Chinese older adults. | Yam, K. K. Shea, Y. F. Chan, T. C. Chiu, K. C. Luk, J. K. Chu, L. W. Chan, F. H. | Geriatrics & Gerontology International | 2018 |
Chinese |
| Home-based Cognitive Prehabilitation in Older Surgical Patients: A Feasibility Study. | Vlisides, P. E. Das, A. R. Thompson, A. M. Kunkler, B. Zierau, M. Cantley, M. J. McKinney, A. M. Giordani, B. | J Neurosurg Anesthesiol | 2018 | |
| Meta-analysis of Prevalence and Risk Factors for Delirium After Transcatheter Aortic Valve Implantation. | Tilley, E. Psaltis, P. J. Loetscher, T. Davis, D. H. Harrison, S. L. Kim, S. Keage, H. A. D. | Am J Cardiol | 2018 | |
| Development and feasibility of a smartphone-based test for the objective detection and monitoring of attention impairments in delirium in the ICU. | Tang, E. Laverty, M. Weir, A. Wilson, E. S. Walsh, T. S. Allerhand, M. Parks, S. MacLullich, A. M. J. Tieges, Z. | J Crit Care | 2018 |
Arousal |
| Retrospective Analysis of Perioperative Variables Associated With Postoperative Delirium and Other Adverse Outcomes in Older Patients After Spine Surgery. | Susano, M. J. Scheetz, S. D. Grasfield, R. H. Cheung, D. Xu, X. Kang, J. D. Smith, T. R. Lu, Y. Groff, M. W. Chi, J. H. Crosby, G. Culley, D. J. | J Neurosurg Anesthesiol | 2018 | |
| Delirium detection by a novel bispectral electroencephalography device in general hospital. | Shinozaki, G. Chan, A. C. Sparr, N. A. Zarei, K. Gaul, L. N. Heinzman, J. T. Robles, J. Yuki, K. Chronis, T. J. Ando, T. Wong, T. Sabbagh, S. Weckmann, M. T. Lee, S. Yamada, T. Karam, M. D. Noiseux, N. O. Shinozaki, E. Cromwell, J. W. | Psychiatry Clin Neurosci | 2018 |
Aged |
| Incremental cost and length of stay associated with postprocedure delirium in transcatheter and surgical aortic valve replacement patients in the United States. | Potter, B. J. Thompson, C. Green, P. Clancy, S. | Catheterization and Cardiovascular Interventions | 2018 |
aortic |
| Effect of regional versus general anaesthesia on postoperative delirium in elderly patients undergoing surgery for hip fracture: a systematic review. | Patel, V. Champaneria, R. Dretzke, J. Yeung, J. | BMJ Open | 2018 |
general anaesthesia |
| The Role of Perioperative Statin Use in the Prevention of Delirium After Total Knee Replacement Under Spinal Anesthesia. | Oh, T. K. Park, H. Y. Shin, H. J. Jeon, Y. T. Do, S. H. Hwang, J. W. | J Arthroplasty | 2018 |
analgesics |
| Observational Study Examining the Association of Baseline Frailty and Postcardiac Surgery Delirium and Cognitive Change. | Nomura, Y. Nakano, M. Bush, B. Tian, J. Yamaguchi, A. Walston, J. Hasan, R. Zehr, K. Mandal, K. LaFlam, A. Neufeld, K. J. Kamath, V. Hogue, C. W. Brown, C. H. th | Anesth Analg | 2018 | |
| CAM-ICU may not be the optimal screening tool for early delirium screening in older emergency department patients: a prospective cohort study. | Lucke, J. A. De Gelder, J. Blomaard, L. C. Fogteloo, A. J. Alsma, J. Schuit, S. C. E. Brink, A. De Groot, B. Blauw, G. J. Mooijaart, S. P. | Eur J Emerg Med | 2018 | |
| Relation of postoperative serum S100A12 levels to delirium and cognitive dysfunction occurring after hip fracture surgery in elderly patients. | Li, Q. H. Yu, L. Yu, Z. W. Fan, X. L. Yao, W. X. Ji, C. Deng, F. Luo, X. Z. Sun, J. L. | Brain Behav | 2018 |
S100a12 |
| A scoping review to map empirical evidence regarding key domains and questions in the clinical pathway of delirium in palliative care. | Lawlor, P. G. Rutkowski, N. A. MacDonald, A. R. Ansari, M. T. Sikora, L. Momoli, F. Kanji, S. Wright, D. K. Rosenberg, E. Hosie, A. Pereira, J. L. Meagher, D. Rice, J. Scott, J. Bush, S. H. | J Pain Symptom Manage | 2018 |
analytic framework |
| Arousal changes and delirium in acute medically-ill male older patients with and without dementia: a prospective study during hospitalization. | Lagarto, L. Albuquerque, E. Loureiro, D. Vieira, F. Esteves, P. Neves, S. Teixeira-Verissimo, M. Cerejeira, J. | Aging Ment Health | 2018 |
Arousal |
| Incidence and Prevalence of Delirium Subtypes in an Adult ICU: A Systematic Review and Meta-Analysis. | Krewulak, K. D. Stelfox, H. T. Leigh, J. P. Ely, E. W. Fiest, K. M. | Crit Care Med | 2018 | |
| Association between death and loss of stage N2 sleep features among critically Ill patients with delirium. | Knauert, M. P. Gilmore, E. J. Murphy, T. E. Yaggi, H. K. Van Ness, P. H. Han, L. Hirsch, L. J. Pisani, M. A. | J Crit Care | 2018 |
Critical illness |
| Preventing Postoperative Delirium After Major Noncardiac Thoracic Surgery-A Randomized Clinical Trial. | Khan, B. A. Perkins, A. J. Campbell, N. L. Gao, S. Khan, S. H. Wang, S. Fuchita, M. Weber, D. J. Zarzaur, B. L. Boustani, M. A. Kesler, K. | J Am Geriatr Soc | 2018 |
Icu |
| Effect of nonpharmacological interventions for the prevention of delirium in the intensive care unit: A systematic review and meta-analysis. | Kang, J. Lee, M. Ko, H. Kim, S. Yun, S. Jeong, Y. Cho, Y. | J Crit Care | 2018 |
Delirium |
| Assessment of Instruments for Measurement of Delirium Severity: A Systematic Review. | Jones, R. N. Cizginer, S. Pavlech, L. Albuquerque, A. Daiello, L. A. Dharmarajan, K. Gleason, L. J. Helfand, B. Massimo, L. Oh, E. Okereke, O. I. Tabloski, P. Rabin, L. A. Yue, J. Marcantonio, E. R. Fong, T. G. Hshieh, T. T. Metzger, E. D. Erickson, K. Sc | JAMA Intern Med | 2018 | |
| Nurses' Recognition of Hospitalized Older Patients With Delirium and Cognitive Impairment Using the Delirium Observation Screening Scale: A Prospective Comparison Study. | Hasemann, W. Tolson, D. Godwin, J. Spirig, R. Frei, I. A. Kressig, R. W. | J Gerontol Nurs | 2018 | |
| Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium. | Halaas, N. B. Blennow, K. Idland, A. V. Wyller, T. B. Raeder, J. Frihagen, F. Staff, A. C. Zetterberg, H. Watne, L. O. | Dement Geriatr Cogn Disord | 2018 |
*Blood and cerebrospinal fluid biomarker |
| Delirium Subtypes and Associated Characteristics in Older Patients With Exacerbation of Chronic Conditions. | Gual, N. Inzitari, M. Carrizo, G. Calle, A. Udina, C. Yuste, A. Morandi, A. | Am J Geriatr Psychiatry | 2018 |
Delirium motor subtypes |
| Antimicrobial exposure and the risk of delirium in critically ill patients. | Grahl, J. J. Stollings, J. L. Rakhit, S. Person, A. K. Wang, L. Thompson, J. L. Pandharipande, P. P. Ely, E. W. Patel, M. B. | Crit Care | 2018 |
*Antibiotics |
| Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness. | Girard, T. D. Exline, M. C. Carson, S. S. Hough, C. L. Rock, P. Gong, M. N. Douglas, I. S. Malhotra, A. Owens, R. L. Feinstein, D. J. Khan, B. Pisani, M. A. Hyzy, R. C. Schmidt, G. A. Schweickert, W. D. Hite, R. D. Bowton, D. L. Masica, A. L. Thompson, J. | N Engl J Med | 2018 | |
| A Systematic Review and Meta-Analysis Examining the Impact of Sleep Disturbance on Postoperative Delirium. | Fadayomi, A. B. Ibala, R. Bilotta, F. Westover, M. B. Akeju, O. | Crit Care Med | 2018 | |
| Pharmacologic Treatment of Intensive Care Unit Delirium and the Impact on Duration of Delirium, Length of Intensive Care Unit Stay, Length of Hospitalization, and 28-Day Mortality. | Daniels, L. M. Nelson, S. B. Frank, R. D. Park, J. G. | Mayo Clin Proc | 2018 | |
| Incidence and clinical significance of postoperative delirium after brain tumor surgery. | Budenas, A. Tamasauskas, S. Sliauzys, A. Navickaite, I. Sidaraite, M. Pranckeviciene, A. Deltuva, V. P. Tamasauskas, A. Bunevicius, A. | Acta Neurochir (Wien) | 2018 |
Brain tumor |
| Role of perceived stress in postoperative delirium: an investigation among elderly patients. | Banjongrewadee, M. Wongpakaran, N. Wongpakaran, T. Pipanmekaporn, T. Punjasawadwong, Y. Mueankwan, S. | Aging Ment Health | 2018 |
Perceived stress |
| Predictors and Sequelae of Postoperative Delirium in Geriatric Hip Fracture Patients. | Arshi, A. Lai, W. C. Chen, J. B. Bukata, S. V. Stavrakis, A. I. Zeegen, E. N. | Geriatr Orthop Surg Rehabil | 2018 |
delirium |
| Operative and anaesthetic factors influencing on delirium in the intensive care unit: An Analysis of electronic health records. | An, Y. S. Jin, Y. Jin, T. Hur, E. Y. Lee, S. M. | J Clin Nurs | 2018 |
delirium |
| Effect of anticholinergic burden on treatment modification, delirium and mortality in newly diagnosed dementia patients starting a cholinesterase inhibitor: a population-based study. | Ah, Y. M. Suh, Y. Jun, K. Hwang, S. Lee, J. Y. | Basic Clin Pharmacol Toxicol | 2018 |
Alzheimer’s disease |
| Postoperative Delirium in Individuals Undergoing Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis. | Abawi, M. Pagnesi, M. Agostoni, P. Chiarito, M. van Jaarsveld, R. C. van Dongen, C. S. Slooter, A. J. C. Colombo, A. Kooistra, N. H. M. Doevendans, Pafm Latib, A. Stella, P. R. | J Am Geriatr Soc | 2018 |
Tavr |
| Effect of goal-directed fluid therapy on early cognitive function in elderly patients with spinal stenosis: A Case-Control Study. | Zhang, N. Liang, M. Zhang, D. D. Xiao, Y. R. Li, Y. Z. Gao, Y. G. Cai, H. D. Lin, X. Z. Lin, C. Z. Zeng, K. Wu, X. D. | Int J Surg | 2018 |
Elderly patients |
| Rehospitalization following a stay in geriatric rehabilitation wards: rates and predictive factors. | Tardivel, M. Muller, F. Tortrat, D. Lechowski, L. Teillet, L. | Geriatr Psychol Neuropsychiatr Vieil | 2018 |
geriatric post-acute and rehabilitation care wards |
| Elimination of Routine Benzodiazepine Administration for Nonprocedural Sedation in a Trauma Intensive Care Unit Is Feasible. | McGinn, K. Davis, S. N. Terrry, E. Simmons, J. Brevard, S. | Am Surg | 2018 |
Adult |
| Can Chaotic Analysis of Electroencephalogram Aid the Diagnosis of Encephalopathy? | Jacob, J. E. Cherian, A. Gopakumar, K. Iype, T. Yohannan, D. G. Divya, K. P. | Neurology Research International | 2018 |
adult |
| Hospital outcomes of older people with cognitive impairment: An integrative review. | Fogg, C. Griffiths, P. Meredith, P. Bridges, J. | Int J Geriatr Psychiatry | 2018 |
cognitive dysfunction |
| Physostigmine is superior to non-antidote therapy in the management of antimuscarinic delirium: a prospective study from a regional poison center. | Boley, S. P. Olives, T. D. Bangh, S. A. Fahrner, S. Cole, J. B. | Clin Toxicol | 2018 |
Physostigmine |
| Cholinesterase inhibitors for the treatment of delirium in non-ICU settings. | Yu, A. Wu, S. Zhang, Z. Dening, T. Zhao, S. Pinner, G. Xia, J. Yang, D. | Cochrane Database of Systematic Reviews | 2018 |