What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Psychiatric Etiologies and Approaches in Altered Mental Status Presentations: Insights from Consultation Liaison Psychiatry | Hamm, B. Rosenthal, L. J. | Semin Neurol | 2024 |
Altered mental status Psychiatry Delirium
|
| Bispectral Index Monitoring Effect on Delirium Occurrence and Nursing Quality Improvement in Post-anesthesia Care Unit Patients Recovering From General Anesthesia: A Randomized Controlled Trial | Huang, Y. Huang, L. Xu, J. Bao, Y. Qu, Y. Huang, Y. | Cureus | 2024 |
bispectral index |
| Impact of Frailty and Delirium Among Older Adults Admitted With Acute Decompensated Heart Failure | Irizarry-Caro, J. A. Kumar, M. Wang, Q. Rohant, N. Goyal, P. Damluji, A. A. Kirkpatrick, J. N. Kwak, M. J. | JACC Adv | 2024 |
acute decompensated heart failure |
| Improving hospice delirium guideline adoption through an understanding of barriers and facilitators: A mixed-methods study | Jackson, C. Malia, C. Zacharias, H. Dyson, J. Johnson, M. J. | PLoS One | 2024 |
Humans |
| Machine learning-based delirium prediction in surgical in-patients: a prospective validation study | Jauk, S. Kramer, D. Sumerauer, S. Veeranki, S. P. K. Schrempf, M. Puchwein, P. | JAMIA Open | 2024 |
clinical decision support
delirium
electronic health records
prediction algorithms
random forest
|
| Risk factors for postoperative delirium in patients with cardiac surgery | Kim, M. S. Kim, S. H. | Sci Prog | 2024 |
Humans |
| Delirium in the ICU: how much do we know? A narrative review | Liu, S. B. Wu, H. Y. Duan, M. L. Yang, R. L. Ji, C. H. Liu, J. J. Zhao, H. | Ann Med | 2024 |
*Delirium/diagnostic imaging/pathology/therapy |
| The role of C-reactive protein as a risk marker of postoperative delirium in older hip fracture patients: a prospective cohort study | Lozano-Vicario, L. Muñoz-Vázquez Á, J. Cedeno-Veloz, B. A. Romero-Ortuno, R. Galbete, A. Fernández-Irigoyen, J. Santamaría, E. Zambom-Ferraresi, F. Ortiz-Gómez, J. R. Hidalgo-Ovejero Á, M. Martínez-Velilla, N. | Eur Geriatr Med | 2024 |
C-reactive protein |
| Low-dose clonidine infusion to improve sleep in postoperative patients in the high-dependency unit. A randomised placebo-controlled single-centre trial | Liu, D. Hallt, E. Platz, A. Humblet, A. Lassig-Smith, M. Stuart, J. Fourie, C. Livermore, A. McConnochie, B. Y. Starr, T. Herbst, K. Woods, C. A. Pincus, J. M. Reade, M. C. | Intensive Care Med | 2024 |
Clonidine |
| A nomogram for predicting the risk of postoperative delirium in individuals undergoing cardiovascular surgery | Liu, C. Zhang, L. Tang, W. Zhao, S. Li, M. Li, J. Shao, Y. | Eur J Neurol | 2024 |
cardiovascular surgery |
| Comparative Diagnostic Accuracy of Nursing Delirium Screening Scale Versus Confusion Assessment Method for Postoperative Delirium: A Systematic Review and Meta-Analysis | Lin, C. J. Fick, D. M. Traynor, V. Chen, Y. C. Hsiang, H. F. Chiu, H. Y. | J Clin Nurs | 2024 |
Confusion Assessment Method |
| The clinical value of nonpharmacological interventions for preventing postoperative delirium: a narrative review | Li, T. Feng, Z. Hou, Y. Li, P. | Minerva Anestesiol | 2024 |
Humans |
| N-methyl-d-aspartate (NMDA) receptor antagonists for treatment of catatonia in adults: Narrative review | Lee, J. H. Suzuki, J. | Gen Hosp Psychiatry | 2024 |
Amantadine |
| Postoperative Delirium Following Posterior Lumbar Spinal Fusion: Epidemiology, Risk Factors, and Associated Complications | Knebel, A. Singh, M. Rasquinha, R. Daher, M. Nassar, J. E. Hanna, J. Diebo, B. G. Daniels, A. H. | World Neurosurg | 2024 |
Complications |
| Co-designing a digital family-led intervention for delirium prevention and management in adult critically ill patients: An application of the double diamond design process | Johnson, G. U. Towell-Barnard, A. McLean, C. Robert, G. Ewens, B. | Int J Nurs Stud | 2024 |
Co-design |
| Reduction of Rehospitalization With Addition of Geriatrics/Transitions of Care Consult Service | Jackson, A. E. Brubaker, A. N. Coffey, C. R. Kalender-Rich, J. L. | J Am Med Dir Assoc | 2024 |
Long-term care |
| Postoperative neurocognitive disorders in ambulatory surgery: a narrative review | In, J. Chen, B. Bae, H. Kinjo, S. | Korean J Anesthesiol | 2024 |
Humans |
| Preoperative assessment of hyperactive delirium risk after head and neck surgery with free tissue transfer reconstruction | Imai, T. Takasago, T. Nakanome, A. Morita, S. Miyakura, Y. Sasaki, K. Ito, K. Goto, T. Asada, Y. | Auris Nasus Larynx | 2024 |
Head and neck neoplasms |
| Long-Term Impact of Delirium on the Risk of Dementia in Hospitalized Older Patients: A Real-World Multicenter Study | Hwang, G. Park, C. Son, S. J. Roh, H. W. Hwang, J. Y. Jang, J. W. Jo, Y. T. Byeon, G. Youn, H. Park, R. W. | Am J Geriatr Psychiatry | 2024 |
Alzheimer’s disease |
| Comprehensive signal detection of delirium-associated medication using the Food and Drug Administration Adverse Event Reporting System | Hatano, M. Sogawa, R. Shin, K. Esumi, S. Ishikawa, A. Mizumura, R. Araki, H. Yamada, S. | Gen Hosp Psychiatry | 2024 |
Humans |
| Inhibited hypoxia-inducible factor by intraoperative hyperglycemia increased postoperative delirium of aged patients: A review | Han, Y. Ji, B. Leng, Y. Xie, C. | Medicine (Baltimore) | 2024 |
Humans |
| Development and Validation of Machine Learning Models to Predict Postoperative Delirium Using Clinical Features and Polysomnography Variables | Ha, W. S. Choi, B. K. Yeom, J. Song, S. Cho, S. Chu, M. K. Kim, W. J. Heo, K. Kim, K. M. | J Clin Med | 2024 |
machine learning |
| Association between baseline serum bicarbonate and the risk of postoperative delirium in patients undergoing cardiac surgery in the ICU: a retrospective study from the MIMIC-IV database | Guo, P. Ma, Y. Su, W. Xie, D. Li, X. Wang, K. Wang, P. | BMC Anesthesiol | 2024 |
Humans |
| Non-pharmacological delirium detection and management interventions for informal caregivers of older people at home: A scoping review protocol | Fox, M. T. Maimets, I. K. Butler, J. I. Sidani, S. Godfrey, C. | PLoS One | 2024 |
Humans |
| Delirium in nursing home residents: is there a role of antidepressants? A cross sectional study | Fedecostante, M. Balietti, P. Di Santo, S. G. Zambon, A. Marengoni, A. Morandi, A. Beccacece, A. Bellelli, G. Cherubini, A. | BMC Geriatr | 2024 |
Humans |
| The use of peripheral nerve block decrease incidence of postoperative cognitive dysfunction following orthopedic surgery: A systematic review and meta-analysis | Deng, L. Jiao, B. Cai, J. Xu, X. Chen, M. Yan, C. Zhu, T. Liu, J. Ma, D. Chen, C. | BMC Anesthesiol | 2024 |
Humans |
| Optimizing anesthesia management based on early identification of electroencephalogram burst suppression risk in non-cardiac surgery patients: a visualized dynamic nomogram | Chen, J. Li, W. Chen, Q. Zhou, Z. Chen, C. Hu, Y. Si, Y. Zou, J. | Ann Med | 2024 |
Humans |
| Routine cognitive screening for older people undergoing major elective surgery: Benefits, risks and costs | Chan, L. K. Chuan, A. Berney, C. R. Chan, D. K. | Anaesth Intensive Care | 2024 |
Humans |
| Prevalence and risk factors of subsyndromal delirium in ICU: A systematic review and meta-analysis | Ma, X. Cheng, H. Zhao, Y. Zhu, Y. | Intensive Crit Care Nurs | 2024 |
Intensive care unit |
| Predisposing and precipitating factors for the development of postoperative delirium in critically ill patients in a university intensive care unit | Marques, D. M. Alves, Ddsb Vernaglia, T. V. C. | Rev Lat Am Enfermagem | 2024 |
Humans |
| Diagnostic test accuracy of screening tools for the detection of neurocognitive disorders in older adults post-trauma: A protocol for a systematic review | Merriman, N. A. Walsh, M. E. O'Regan, N. Carrigan, M. Hickey, P. Brent, L. Blake, C. | HRB Open Res | 2024 |
cognition |
| How much risk does delirium represent for the development of dementia?: Retrospective cohort study from over 260,000 patients record in a solitary institution | Minami, H. Toyoda, K. Hata, T. Nishihara, M. Neo, M. Nishida, K. Kanazawa, T. | Front Psychiatry | 2024 |
cognitive decline |
| Effectiveness of the ABCDEF Bundle to Manage and Prevent Delirium: Pre- and Postintervention Quasi-Experimental Study | Nagy Nagm Eldean, T. Hassan Bakri, M. Anwar Abdel Aziz, M. Shalaby Khalaf, G. | Crit Care Nurs Q | 2024 |
Humans |
| C reactive protein albumin ratio as a new predictor of postoperative delirium after cholecystectomy for acute cholecystitis | Nakatake, R. Funatsuki, T. Koshikawa, Y. Okuyama, T. Ishizaki, M. Takekita, Y. Kato, M. Kitade, H. | Sci Rep | 2024 |
Humans |
| The impact of preoperative psychiatric intervention for postoperative delirium after major oral and maxillofacial surgery with free flap reconstruction | Nitta, Y. Sanuki, T. Sugino, S. Sugimoto, M. Kido, K. | J Stomatol Oral Maxillofac Surg | 2024 |
Free flap reconstruction |
| Impact of beta-blocker usage on delirium in patients with sepsis in ICU: a cross-sectional study | Ouyang, H. Wang, X. Deng, D. Wang, Q. Yu, Y. | Front Med (Lausanne) | 2024 |
ICU stay |
| Utilization of NIRS Monitor to Compare the Regional Cerebral Oxygen Saturation Between Dexmedetomidine and Propofol Sedation in Mechanically Ventilated Critically ill Patients with Sepsis- A Prospective Randomized Control Trial | Patidar, A. K. Khanna, P. Kashyap, L. Ray, B. R. Maitra, S. | J Intensive Care Med | 2024 |
delirium |
| Postoperative Delirium and Neurocognitive Disorders: A Comprehensive Review of Pathophysiology, Risk Factors, and Management Strategies | Paunikar, S. Chakole, V. | Cureus | 2024 |
cognitive impairment |
| Preoperative serum ferritin as a biomarker for predicting delirium among elderly patients receiving non-cardiac surgery: a retrospective cohort study | Ruan, X. Li, Y. Yuan, M. Li, H. Lou, J. Liu, Y. Cao, J. Ma, Y. Mi, W. Zhang, X. | Transl Psychiatry | 2024 |
Humans |
| Circadian disturbances, anxiety and motor disturbances differentiate delirium superimposed on dementia from dementia-only | Schnorr, T. Fleiner, T. Trumpf, R. Prüter-Schwarte, C. Fanselow, J. Zijlstra, W. Haussermann, P. | Front Psychiatry | 2024 |
acute hospital |
| Real-World Adherence to a Delirium Screening Test Administered by Nurses and Medical Staff during Routine Patient Care | Soboh, R. Rotfeld, M. Gino-Moor, S. Jiries, N. Ginsberg, S. Oliven, R. | Brain Sci | 2024 |
Radar |
| Dexmedetomidine for Postoperative Delirium Prevention in the Older Adult: An Integrative Review | Strada, A. L. Tevay, A. Scoggins, M. Gonzalez, K. | Aana j | 2024 |
Humans |
| Improving delirium assessments in acute senior health: A quality improvement project for care of the older person | Taylor, C. Peakman, G. Mackinnon, L. Mohamadzade, N. Han, W. Mackie, L. Gandhi, J. Mitchell, O. Bateman-Champain, C. Hetherington, J. Belarbi, F. Alg, G. | BMC Geriatr | 2024 |
Alzheimer’s disease |
| Postoperative delirium among elderly elective orthopedic patients in Addis Ababa Ethiopia: a multicentere longitudinal study | Tekletsadik, Y. A. Workineh, S. A. Gesso, A. S. Hirbo, H. S. | BMC Anesthesiol | 2024 |
Humans |
| Effect of optimizing cerebral oxygen saturation on postoperative delirium in older patients undergoing one-lung ventilation for thoracoscopic surgery | Teng, P. Liu, H. Xu, D. Feng, X. Liu, M. Wang, Q. | J Int Med Res | 2024 |
Humans |
| Persistent delirium is associated with cerebrospinal fluid markers of neuronal injury | Tsui, A. Johnstone, B. Heslegrave, A. Zetterberg, H. Watne, L. O. Neerland, B. E. Krogseth, M. Cunningham, C. MacLullich, A. Muniz Terrera, G. Davis, D. Caplan, G. | Brain Commun | 2024 |
CSF biomarkers |
| A Retrospective Study Establishing a Nomogram Predictive Model for Postoperative High-Activity Delirium After Non-Cardiac Surgery | Tu, Y. Du, W. Pan, Y. Zhang, X. Mo, Y. Sun, C. Wang, J. | Neuropsychiatr Dis Treat | 2024 |
Pacu |
| Safe Landing: Feasibility and Safety of Operating Room Extubation in Minimally Invasive Cardiac Valve Surgery | Wang, C. C. DeBose-Scarlett, A. Irlmeier, R. Ye, F. Siegrist, K. Shah, A. S. Kingeter, M. | J Cardiothorac Vasc Anesth | 2024 |
intubation duration |
| Intraoperative hypotension and postoperative delirium in elderly male patients undergoing laryngectomy: a single-center retrospective cohort study | Wang, Y. Chen, K. Ye, M. Shen, X. | Braz J Anesthesiol | 2024 |
Hypotension |
| Perioperative Risk Factors for Postoperative Delirium in Non-Dementia Older Patients after Non-Cardiac Surgery and Anesthesia: A Prospective Study | Wattanaboot, N. Kuawatcharawong, W. Permsakmesub, P. | Ann Geriatr Med Res | 2024 |
Postoperative delirium |
| Association of preoperative frailty with risk of postoperative delirium in older patients undergoing craniotomy: a prospective cohort study | Wei, L. Liu, M. Zhang, S. Chen, Y. Wu, M. Chen, X. Liu, J. He, Y. Yang, X. Xian, J. | BMC Surg | 2024 |
Humans |
| Geriatric nutritional risk index predicts postoperative delirium in elderly: A meta-analysis | Xie, S. Wu, Q. | Saudi Med J | 2024 |
Humans |
| Intensive care unit interventions to promote sleep and circadian biology in reducing incident delirium: a scoping review | Wilcox, M. E. Burry, L. Englesakis, M. Coman, B. Daou, M. van Haren, F. M. Ely, E. W. Bosma, K. J. Knauert, M. P. | Thorax | 2024 |
Humans |
| Theory-based and evidence-based nursing interventions for the prevention of ICU-acquired weakness in the intensive care unit: A systematic review | Xu, Q. Tan, J. Wang, Y. Tang, M. | PLoS One | 2024 |
Humans |
| Transradial versus transfemoral access for middle meningeal artery embolization: Choice of the access route considering delirium in the elderly | Yamamoto, M. Fujiwara, G. Takezawa, H. Uzura, Y. Yokoya, S. Oka, H. | Surg Neurol Int | 2024 |
Chronic subdural hematoma |
| The effect of perioperative dexmedetomidine on postoperative delirium in adult patients undergoing cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis of randomized controlled trials | Zhuang, X. Fu, L. Luo, L. Dong, Z. Jiang, Y. Zhao, J. Yang, X. Hei, F. | BMC Anesthesiol | 2024 |
Adult |
| Incidence and associated factors of delirium after primary total joint arthroplasty in elderly patients: A systematic review and meta-analysis | Zhang, Y. Yu, Y. Han, Z. Diao, L. Zhao, R. Liu, J. Luo, Y. Wu, H. Yang, Y. | Medicine (Baltimore) | 2024 |
Aged |
| The effect of two different modes of anaesthesia maintenance on postoperative delirium in elderly patient with low preoperative mini-cog score | Duran, H. T. Kızılkaya, M. Aydinli, A. Osmantevfik, S. Taştan, S. Kılınç, OÖ Pirhan, Y. | BMC Anesthesiol | 2024 |
Aged |
| Extracellular Vesicle MicroRNAs as Predictive Biomarkers in Postoperative Delirium After Spine Surgery: Preliminary Study | Cho, Y. E. Kim, J. Vorn, R. Cho, H. Baek, W. Park, H. Yun, S. Kim, H. S. Cashion, A. K. Gill, J. Koo, B. N. Lee, H. | J Gerontol A Biol Sci Med Sci | 2024 |
Humans |
| Exploring the role of calf circumference as a predisposing factor for intra-hospital delirium: investigating potential gender differences: revealing potential gender variances | Ceolin, C. Papa, M. V. Simonato, C. Cazzavillan, S. Vergadoro, M. Trapella, G. S. Sermasi, R. De Rui, M. Noale, M. Zanforlini, B. M. Curreri, C. Bertocco, A. Devita, M. Sergi, G. Coin, A. | BMC Geriatr | 2024 |
Humans |
| Neurophysiological patterns reflecting vulnerability to delirium subtypes: a resting-state EEG and event-related potential study | Boord, M. S. Feuerriegel, D. Coussens, S. W. Davis, D. H. J. Psaltis, P. J. Garrido, M. I. Bourke, A. Keage, H. A. D. | Brain Commun | 2024 |
Eeg |
| Delirium in Lower Limb Trauma: The Incidence and Risk Factors in a Prospective Observational Study | Balachandran, A. Nagar, M. Behera, P. Kashyap, P. | Indian J Orthop | 2024 |
adults |
| Diurnal variation of postoperative delirium in elderly patients undergoing esketamine anesthesia for elective noncardiac surgery: a randomized clinical trial | Zhang, Y. Chen, R. Tang, S. Sun, T. Yu, Y. Shi, R. Wang, K. Zeng, Z. Liu, X. Meng, Q. Xia, Z. | Int J Surg | 2024 |
Humans |
| Recent developments in delirium after oral and maxillofacial free-flap reconstruction | Zhang, R. Zhang, W. Ren, Y. Yu, J. Li, L. Zhang, Y. | J Stomatol Oral Maxillofac Surg | 2024 |
Oral and maxillofacial free-flap reconstruction |
| A longitudinal multimodal MRI study of the visual network in postoperative delirium | Zhang, G. Qi, B. Li, H. Zhang, X. Chen, J. Li, H. Jing, B. Huang, H. | Brain Imaging Behav | 2024 |
Frontal glioma |
| Association between Intraoperative Hypotension and Postoperative Delirium: A Retrospective Cohort Analysis | Zarour, S. Weiss, Y. Abu-Ghanim, M. Iacubovici, L. Shaylor, R. Rosenberg, O. Matot, I. Cohen, B. | Anesthesiology | 2024 |
Humans |
| Incidence and relative risk of delirium after major surgery for patients with pre-operative depression: a systematic review and meta-analysis | Diep, C. Patel, K. Petricca, J. Daza, J. F. Lee, S. Xue, Y. Kremic, L. Xiao, M. Z. X. Pivetta, B. Vigod, S. N. Wijeysundera, D. N. Ladha, K. S. | Anaesthesia | 2024 |
delirium |
| Pharmacologic Treatment Strategies for Delirium in Hospitalized Adults: Past, Present, and Future | Devlin, J. W. | Semin Neurol | 2024 |
Delirium Cognitive decline Non-pharmacological interventions Risk factors ICU Delirium |
| Reperfusion therapy and risk of post-stroke delirium | Czyzycki, M. Pera, J. Dziedzic, T. | Neurol Res | 2024 |
Delirium |
| Implementation of delirium screening in the emergency department: A qualitative study with early adopters | Chary, A. N. Bhananker, A. R. Brickhouse, E. Torres, B. Santangelo, I. Godwin, K. M. Naik, A. D. Carpenter, C. R. Liu, S. W. Kennedy, M. | J Am Geriatr Soc | 2024 |
delirium |
| Practical prognostic tools to predict the risk of postoperative delirium in older patients undergoing cardiac surgery: visual and dynamic nomograms | Bah, C. S. Mbambara, B. Xie, X. Li, J. Iddi, A. K. Chen, C. Jiang, H. Feng, Y. Zhong, Y. Zhang, X. Xia, H. Yan, L. Si, Y. Zhang, J. Zou, J. | J Clin Monit Comput | 2024 |
Cardiac surgery |
| Validation of the delirium diagnostic tool-provisional (DDT-Pro) in geriatric medical inpatients with diagnostic permutations of the 3Ds with and without delirium | Botero Urrea, M. González, M. C. Villa García, M. M. Alviz Núñez, M. Velásquez-Tirado, J. D. Ocampo, M. V. Trzepacz, P. T. Franco, J. G. | J Psychosom Res | 2024 |
Humans Female |
| Delirium Mediated the Association Between a History of Falls and Short-Term Mortality Risk in Critically Ill Ischemic Stroke Patients | Cheng, H. Xu, X. Tang, Y. Yang, X. Ling, Y. Tan, S. Wang, Z. Ming, W. K. Lyu, J. | Clin Nurs Res | 2024 |
Icu |
| Risk factors for postoperative delirium in frail elderly patients undergoing on-pump cardiac surgery and development of a prediction model-a prospective observational study | Ding, Y. Gao, J. Ge, Y. Huang, T. Zhang, Y. | Front Cardiovasc Med | 2024 |
cardiac surgery |
| Effect of intra-operative Magnesium sulphate on the occurrence of post-operative delirium and insomnia in patients undergoing lumbar fixation: a randomized controlled trial | Fathy, W. Hussein, M. Elanwar, R. Elmoutaz, H. Abdelsadek, D. A. Kassim, D. Y. | BMC Anesthesiol | 2024 |
Humans |
| Predicting postoperative delirium assessed by the Nursing Screening Delirium Scale in the recovery room for non-cardiac surgeries without craniotomy: A retrospective study using a machine learning approach | Giesa, N. Haufe, S. Menk, M. Weiß, B. Spies, C. D. Piper, S. K. Balzer, F. Boie, S. D. | PLOS Digit Health | 2024 |
Postoperative Delirium Risk factors Non-linear machine learning Fluctuation Recovery Nurse Screening Delirium Scale |
| A Comparative Analysis of the Effects of Haloperidol and Dexmedetomidine on QTc Interval Prolongation during Delirium Treatment in Intensive Care Units | Haspolat, A. Polat, F. Köprülü, AŞ | J Crit Care Med (Targu Mures) | 2024 |
QTc interval |
| Effect of mannitol on postoperative delirium in patients undergoing coronary artery bypass graft: a randomised controlled trial | Hemmati Maslakpak, M. Negargar, S. Farbod, A. Khalili, A. Bilehjani, E. Alinejad, V. Faravan, A. | Open Heart | 2024 |
Humans |
| Assessing Delirium Severity in Dementia: Item Development and Psychometric Validation for a Delirium Severity Instrument | Hshieh, T. Schulman-Green, D. Fong, T. G. Metzger, E. Arias, F. Helfand, B. Marcantonio, E. Schmitt, E. Tabloski, P. Jones, R. N. Inouye, S. K. | J Gerontol Nurs | 2024 |
Humans |
| The development of a family-led novel intervention for delirium prevention and management in the adult intensive care unit: A co-design qualitative study | Johnson, G. U. Towell-Barnard, A. McLean, C. Ewens, B. | Aust Crit Care | 2024 |
Co-design |
| Disparities in Delirium across the Continuum of Care and Associations with Social Determinants of Health | Khanna, A. Govil, M. Ayele, N. Saadi, A. | Semin Neurol | 2024 |
Delirium identification Delirium treatment Disparities Social-ecological model Social determinants of health |
| The effect of non-steroidal anti-inflammatory drugs on postoperative delirium: a meta-analysis | Kim, S. Y. Na, H. S. Ryu, J. H. Shin, H. J. | Korean J Anesthesiol | 2024 |
Cognitive dysfunction |
| Management of delirium in acute stroke patients: a position paper by the Austrian Stroke Society on prevention, diagnosis, and treatment | Kneihsl, M. Berger, N. Sumerauer, S. Asenbaum-Nan, S. Höger, F. S. Gattringer, T. Enzinger, C. Aigner, M. Ferrari, J. Lang, W. | Ther Adv Neurol Disord | 2024 |
acute stroke |
| Assessment of cognition: dementia and delirium : In consideration of the AWMF guidelines 038-013 and 084-002LG | Krupp, S. Iglseder, B. | Z Gerontol Geriatr | 2024 |
Cognitive impairments |
| Retrospective comparison of the effects of remimazolam and dexmedetomidine on postoperative delirium in elderly patients undergoing orthopedic surgery of the lower extremities under spinal anesthesia | Lee, S. Oh, C. Jung, J. Hong, B. Jo, Y. Lee, S. Lim, C. Baek, S. Shin, M. Seo, H. Chung, W. | J Anesth | 2024 |
Benzodiazepines |
| Cluster nursing care based on 10S continuous quality improvement reduces incidence of postoperative delirium in BPH patients | Li, R. X. Liu, J. Jin, P. Ye, X. Q. Xu, S. | Zhonghua Nan Ke Xue | 2024 |
Humans |
| Elderly patients with dysphagia in the intensive care unit: Association between malnutrition and delirium | Liang, X. Li, X. Cheng, H. Wei, F. Li, T. Li, Y. Huang, Y. Lyu, J. Wang, Y. | Nurs Crit Care | 2024 |
critical care nursing |
| Global Research Trends in Postoperative Delirium and Its Risk Factors: A Bibliometric and Visual Analysis | Liu, X. Huangfu, Z. Zhang, X. Ma, T. | J Perianesth Nurs | 2024 |
bibliometrics |
| Intensive care nurses' perceptions and awareness of delirium and delirium prevention guidelines | Meghani, S. Timmins, F. | Nurs Crit Care | 2024 |
Humans |
| Characteristics associated with effectiveness in postoperative delirium research: a systematic review of randomised controlled trials with meta-regression and meta-analysis | Meng, L. Zhao, X. Sun, Y. Cheng, S. Bao, L. Fang, K. Yu, Q. Zheng, Y. Wang, J. Luo, M. Gunderman, D. Vuckovic, N. Sidhu, A. S. Li, J. Li, G. Wolfe, J. W. Liu, Z. Adams, D. C. | Br J Anaesth | 2024 |
Humans |
| Electroencephalography as a tool for assessing delirium in hospitalized patients: A single-center tertiary hospital experience | Mohamad Faizal, N. S. Tan, J. K. Tan, M. M. Khoo, C. S. Sahibulddin, S. Z. Zolkafli, N. Hod, R. Tan, H. J. | J Cent Nerv Syst Dis | 2024 |
Delirium |
| Common molecular and pathophysiological underpinnings of delirium and Alzheimer's disease: molecular signatures and therapeutic indications | Mosharaf, M. P. Alam, K. Gow, J. Mahumud, R. A. Mollah, M. N. H. | BMC Geriatr | 2024 |
Humans |
| Evaluation of postoperative delirium in geriatric patients given acetaminophen with and without melatonin: A retrospective cohort study | Muehrcke, M. N. Blackwelder, R. S. Weeda, E. R. Furlough, L. A. Shelton, J. E. Brace, S. M. Bragg, S. W. | Int J Psychiatry Med | 2024 |
comorbidity |
| Effect of intranasal insulin on perioperative cognitive function in older adults: a randomized, placebo-controlled, double-blind clinical trial | Sun, M. Ruan, X. Zhou, Z. Huo, Y. Liu, M. Liu, S. Cao, J. Liu, Y. H. Zhang, X. Ma, Y. L. Mi, W. | Age Ageing | 2024 |
Humans |
| Predictive model of risk factors for 28-day mortality in patients with sepsis or sepsis-associated delirium based on the MIMIC-IV database | Zhang, L. Li, X. Huang, J. Yang, Y. Peng, H. Yang, L. Yu, X. | Sci Rep | 2024 |
Humans |
| Exploring Causal Links Between Gut Microbiota and Geriatric Syndromes: A Two-Sample Mendelian Randomization Analysis | Yao, Q. Chen, L. Cai, Y. Li, C. Wen, S. Yang, C. Zhang, Q. Zeng, Y. Zheng, S. Zou, J. Huang, G. Zeng, Q. | Int J Med Sci | 2024 |
Humans |
| Intranasal administration of insulin on the incidence of postoperative delirium in middle-aged patients undergoing elective on-pump cardiac surgery (INIPOD-MOPS): a prospective double-blinded randomized control study protocol | Yang, M. Yang, G. Lu, T. Cao, L. Xiao, C. Liang, Y. Ding, J. Jiang, X. Wang, W. Chen, F. Du, Z. Li, H. | Trials | 2024 |
Humans |
| Integrated Multi-Omics Analysis of Cerebrospinal Fluid in Postoperative Delirium | Tripp, B. A. Dillon, S. T. Yuan, M. Asara, J. M. Vasunilashorn, S. M. Fong, T. G. Inouye, S. K. Ngo, L. H. Marcantonio, E. R. Xie, Z. Libermann, T. A. Otu, H. H. | Biomolecules | 2024 |
Humans |
| Sex-stratified analyses of comorbidities associated with an inpatient delirium diagnosis using real world data | Sirota, M. Kodama, L. Woldemariam, S. Tang, A. Li, Y. Kornak, J. Allen, I. E. Raphael, E. Oskotsky, T. | Res Sq | 2024 |
Delirium Older Adults Comorbidities Mental Health Inpatient delirium |
| Reasons influencing the nurses' prioritization process while preventing and managing delirium: findings from a qualitative study | Sist, L. Ugenti, N. V. Chiappinotto, S. Messina, R. Rucci, P. Palese, A. | Aging Clin Exp Res | 2024 |
Humans |