What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Antipsychotics in the Treatment of Delirium in Critically Ill Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Authors
- Carayannopoulos, K. L. Alshamsi, F. Chaudhuri, D. Spatafora, L. Piticaru, J. Campbell, K. Alhazzani, W. Lewis, K.
- Year
- 2024
- Journal
- Crit Care Med
- Abstract
OBJECTIVES: To conduct a systematic review and meta-analysis assessing whether the use of antipsychotic medications in critically ill adult patients with delirium impacts patient-important outcomes. DATA SOURCES: A medical librarian searched Ovid MEDLINE, EMBASE, APA PsycInfo, and Wiley’s Cochrane Library as well as clinicaltrials.gov and the World Health Organization International Clinical Trials Registry Platform up to November 2023. STUDY SELECTION: Independently and in duplicate, reviewers screened abstracts and titles for eligibility, then full text of qualifying studies. We included parallel-group randomized controlled trials (RCTs) that included critically ill adult patients with delirium. The intervention group was required to receive antipsychotic medications at any dose, whereas the control group received usual care or placebo. DATA EXTRACTION: Reviewers extracted data independently and in duplicate using a piloted abstraction form. Statistical analyses were conducted using RevMan software (version 5.4). DATA SYNTHESIS: Five RCTs ( n = 1750) met eligibility criteria. The use of antipsychotic medications compared with placebo did not increase the number of delirium- or coma-free days (mean difference 0.90 d; 95% CI, -0.32 to 2.12; moderate certainty), nor did it result in a difference in mortality, duration of mechanical ventilation, ICU, or hospital length of stay. The use of antipsychotics did not result in an increased risk of adverse events (risk ratio 1.27; 95% CI, 0.71-2.30; high certainty). Subgroup analysis of typical versus atypical antipsychotics did not identify any subgroup effect for any outcome. CONCLUSIONS: In conclusion, our systematic review and meta-analysis demonstrated with moderate certainty that there is no difference in delirium- or coma-free days when delirious critically ill adults are treated with antipsychotic medications. Further studies in the subset of patients with hyperactive delirium may be of benefit.
- PMID
PMID: 38488422
- Keywords
Antipsychotic medication
Delirium
Systematic review
Critically Ill
Cognitive Impairment
Coma
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Dementia Development during Long-Term Follow-Up after Surgical Aortic Valve Replacement with a Biological Prosthesis in a Geriatric Population | Deblier, I. Dossche, K. Vanermen, A. Mistiaen, W. | J Cardiovasc Dev Dis | 2024 |
dementia |
| A Comparison of Efficacy between Low-dose Dexmedetomidine and Propofol for Prophylaxis of Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery: A Randomized Controlled Trial | Ekkapat, G. Kampitak, W. Theerasuwipakorn, N. Kittipongpattana, J. Engsusophon, P. Phannajit, J. Chokengarmwong, N. | Indian J Crit Care Med | 2024 |
Dexmedetomidine |
| Development and validation of a new drug-focused predictive risk score for postoperative delirium in orthopaedic and trauma surgery patients | Geßele, C. Saller, T. Smolka, V. Dimitriadis, K. Amann, U. Strobach, D. | BMC Geriatr | 2024 |
Humans |
| Preoperative cognitive performance and its association with postoperative complications in vascular surgery patients: A prospective study | Goodijk, D. Banning, L. B. D. Te Velde-Keyzer, C. A. van Munster, B. C. Bakker, S. J. L. van Leeuwen, B. L. Zeebregts, C. J. Pol, R. A. | Am J Surg | 2024 |
Cognition |
| Prognostic Nutritional Index and the Risk of Postoperative Complications After Spine Surgery: A Meta-Analysis | Guo, H. Yang, L. Liu, J. Yu, X. Chen, L. Huang, Y. | World Neurosurg | 2024 |
Humans |
| Risk stratification and predictive modeling of postoperative delirium in chronic subdural hematoma | Yang, X. Regmi, M. Wang, Y. Liu, W. Dai, Y. Liu, S. Lin, G. Yang, J. Ye, J. Yang, C. | Neurosurg Rev | 2024 |
Humans |
| Association between increased systemic immune-inflammation index and postoperative delirium in older intertrochanteric fracture patients | Yan, X. Huang, J. Chen, X. Lin, M. | J Orthop Surg Res | 2024 |
Humans |
| Intravenous infusion of dexmedetomidine during the surgery to prevent postoperative delirium and postoperative cognitive dysfunction undergoing non-cardiac surgery: a meta-analysis of randomized controlled trials | Wang, D. Liu, Z. Zhang, W. Zu, G. Tao, H. Bi, C. | Eur J Med Res | 2024 |
Humans |
| Triglyceride-glucose index predicts postoperative delirium in elderly patients with type 2 diabetes mellitus: a retrospective cohort study | Sun, M. Liu, M. Zhang, F. Sang, L. Song, Y. Li, P. Liu, S. Yang, H. Ma, L. Cao, J. Mi, W. Ma, Y. | Lipids Health Dis | 2024 |
Aged |
| Electroencephalogram Biomarkers from Anesthesia Induction to Identify Vulnerable Patients at Risk for Postoperative Delirium | Pollak, M. Leroy, S. Röhr, V. Brown, E. N. Spies, C. Koch, S. | Anesthesiology | 2024 |
Humans |
| Mesial temporal atrophy in preoperative MRI rather than steep Trendelenburg position is associated with postoperative delirium in patients undergoing a major urologic surgery | Park, J. H. Park, I. Yoon, J. Sim, Y. Kim, J. Lee, S. K. Joo, B. | Int Urol Nephrol | 2024 |
Male |
| Comparison of Remimazolam and Propofol on Postoperative Delirium in Elderly Patients Undergoing Radical Resection of Colon Cancer: A Single-Center Prospective Randomized Controlled Study | Liu, T. Zhao, H. Zhao, X. Qu, M. | Med Sci Monit | 2024 |
Humans |
| Dynamic Delirium Prediction in the Intensive Care Unit using Machine Learning on Electronic Health Records | Contreras, M. Silva, B. Shickel, B. Bandyopadhyay, S. Guan, Z. Ren, Y. Ozrazgat-Baslanti, T. Khezeli, K. Bihorac, A. Rashidi, P. | IEEE EMBS Int Conf Biomed Health Inform | 2023 |
Delirium ICU Machine learning system Delirium Prediction |
| The Role of Delirium on Short- and Long-Term Postoperative Outcomes Following Major Gastrointestinal Surgery for Cancer | Katayama, E. S. Stecko, H. Woldesenbet, S. Khalil, M. Munir, M. M. Endo, Y. Tsilimigras, D. Pawlik, T. M. | Ann Surg Oncol | 2024 |
Delirium Digestive tract surgery Surgical outcomes Postoperative delirium Expenditures |
| Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial | Mart, M. F. Boehm, L. M. Kiehl, A. L. Gong, M. N. Malhotra, A. Owens, R. L. Khan, B. A. Pisani, M. A. Schmidt, G. A. Hite, R. D. Exline, M. C. Carson, S. S. Hough, C. L. Rock, P. Douglas, I. S. Feinstein, D. J. Hyzy, R. C. Schweickert, W. D. Bowton, D. L. | Lancet Respir Med | 2024 |
Delirium Critical illness Antipsychotics Long-term cognitive impairment Haloperidol Ziprasidone |
| Incidence and assessment of delirium following open cardiac surgery; A systematic review and meta-analysis | Petersson, N. B. Hansen, M. H. Hjelmborg, J. V. B. Instenes, I. Christoffersen, A. S. Larsen, K. L. Schmidt, H. Riber, L. P. S. Norekvål, T. M. Borregaard, B. | Eur J Cardiovasc Nurs | 2024 |
Open Cardiac Surgery Delirium Systematic Review CAM CAM-ICU Delirium assessment tools |
| Significance Analysis of the Improvement in Postoperative Recovery of Cardiac Surgery Patients Based on the Graded Management Established Using the Delirium Prediction Model | Zhang, H. Wang, Q. Feng, P. | Altern Ther Health Med | 2024 |
Cardiac Surgery Delirium Prediction Delirium ICU Delirium Type A aortic coarctation |
| Postoperative Delirium and the Older Adult: Untangling the Confusion | Thedim, M. Vacas, S. | J Neurosurg Anesthesiol | 2024 |
aging, anesthesia, delirium, inflammation, sleep |
| Efficacy and safety of music therapy for the treatment of anxiety and delirium in ICU patients: a meta-analysis and systematic review of randomized controlled trials | Xiao, M. Gong, C. Mai, M. Huang, M. Xiong, A. Liu, H. Jiang, R. | Minerva Anestesiol | 2024 |
Music therapy; Intensive care units; Anxiety; Delirium; Meta-analysis |
| Aripiprazole for treating delirium: A systematic review-Is it a valid yet understudied treatment? | Maddalena, S. Magistri, C. Mellini, C. Sarli, G. | J Psychopharmacol | 2024 |
Haloperidol |
| Delirium screening in the emergency department: evaluation and intervention | Meged-Book, T. Frenkel, R. Nikonov, A. Zeldetz, V. Kosto, A. Schwarzfuchs, D. Freud, T. Press, Y. | Isr J Health Policy Res | 2024 |
Humans |
| A Toolkit for Delirium Identification and Promoting Partnerships Between Carers and Nurses: A Pilot Pre-Post Feasibility Study | Aggar, C. Craswell, A. Bail, K. Compton, R. M. Hughes, M. Sorwar, G. Baker, J. Greenhill, J. Shinners, L. Nichols, B. Langheim, R. Wallis, A. Bowen, K. Bridgett, H. | J Gen Intern Med | 2024 |
caregiving |
| The role of heart rate variability in predicting delirium: A systematic review and meta-analysis | Amit Patel, K. Sethi, A. Al Azazi, E. McClurg, C. Chowdhury, T. | J Clin Neurosci | 2024 |
Delirium |
| Efficacy of melatonin in decreasing the incidence of delirium in critically ill adults: a randomized controlled trial | Bandyopadhyay, A. Yaddanapudi, L. N. Saini, V. Sahni, N. Grover, S. Puri, S. Ashok, V. | Crit Care Sci | 2024 |
Humans |
| Assessment and report of individual symptoms in studies of delirium in postoperative populations: a systematic review | Bowman, E. M. L. Sweeney, A. M. McAuley, D. F. Cardwell, C. Kane, J. Badawi, N. Jahan, N. Iqbal, H. K. Mitchell, C. Ballantyne, J. A. Cunningham, E. L. | Age Ageing | 2024 |
Humans |
| Systemic inflammation and delirium during critical illness | Brummel, N. E. Hughes, C. G. McNeil, J. B. Pandharipande, P. P. Thompson, J. L. Orun, O. M. Raman, R. Ware, L. B. Bernard, G. R. Harrison, F. E. Ely, E. W. Girard, T. D. | Intensive Care Med | 2024 |
Coma |
| Hospitalized Patients With Delirium and 28-Day Unplanned Hospital Readmissions: A Longitudinal Retrospective Cohort Study | Butala, A. Gilbert, J. M. Griffiths, A. A. Lim, W. K. | J Am Med Dir Assoc | 2024 |
Delirium |
| Validity and reliability of the Turkish version of the Informant Assessment of Geriatric Delirium Scale | Celik, B. Bilik, O. Koçbilek, Z. D. Damar, H. T. Öz, D. Denizmen, Z. | Ideggyogy Sz | 2024 |
Aged |
| Can admission Braden skin score predict delirium in older adults in the intensive care unit? Results from a multicenter study | Cheng, H. Huang, X. Yuan, S. Song, S. Tang, Y. Ling, Y. Tan, S. Wang, Z. Zhou, F. Lyu, J. | J Clin Nurs | 2024 |
Humans |
| Malnutrition-Related Health Outcomes in Older Adults with Hip Fractures: A Systematic Review and Meta-Analysis | Chiavarini, M. Ricciotti, G. M. Genga, A. Faggi, M. I. Rinaldi, A. Toscano, O. D. D'Errico, M. M. Barbadoro, P. | Nutrients | 2024 |
Humans |
| Organizational Context and Facilitation Interactions on Delirium Risk in Long-Term Care: A Cross-Sectional Study | Choroschun, K. Estabrooks, C. A. Duan, Y. Chamberlain, S. Shrestha, S. Cummings, G. G. Iaconi, A. Norton, P. G. Song, Y. Hoben, M. | J Am Med Dir Assoc | 2024 |
Organizational context |
| Delirium and delirium severity screening in the intensive care-correspondence of screenings tools | Collet, M. O. Nielsen, A. H. Larsen, L. K. Laerkner, E. Jensen, J. F. Mortensen, C. B. Lehmkuhl, L. Thorn, L. Rossen, B. S. Nielsen, T. A. Laursen, E. Shiv, L. H. Villumsen, M. Rahr, M. N. Svenningsen, H. | Aust Crit Care | 2024 |
Adult |
| A joint frailty model for recurrent and competing terminal events: Application to delirium in the ICU | Etzkorn, L. H. Coënt, Q. L. van den Boogaard, M. Rondeau, V. Colantuoni, E. | Stat Med | 2024 |
competing events |
| Nomogram for predicting the risk of postoperative delirium in elderly patients undergoing orthopedic surgery | Fan, Y. Yang, T. Liu, Y. Gan, H. Li, X. Luo, Y. Yang, X. Pang, Q. | Perioper Med (Lond) | 2024 |
Elderly patients |
| The Association of Plasma Leptin, Soluble Leptin Receptor and Total and High-Molecular Weight Adiponectin With the Risk of Perioperative Neurocognitive Disorders | Feinkohl, I. Janke, J. Slooter, A. J. C. Winterer, G. Spies, C. Pischon, T. | Am J Geriatr Psychiatry | 2024 |
Adiponectin |
| A novel nomogram for the prediction of subsyndromal delirium in patients in intensive care units: A prospective, nested case-controlled study | Gao, Y. Gan, X. | Int J Nurs Stud | 2024 |
Delirium |
| Association Between Preoperative Sleep Disturbance and Postoperative Delirium in Elderly: A Retrospective Cohort Study | Guo, H. Li, L. H. Lv, X. H. Su, F. Z. Chen, J. Xiao, F. Shi, M. Xie, Y. B. | Nat Sci Sleep | 2024 |
anesthesia |
| Validation to Spanish of nursing assessment scale for early diagnosis of delirium - Nu-DESC | Henao Castaño Á, M. Lozano González, L. M. Gómez Tovar, L. O. | Invest Educ Enferm | 2023 |
Adult |
| Predictive modeling for postoperative delirium in elderly patients with abdominal malignancies using synthetic minority oversampling technique | Hu, W. J. Bai, G. Wang, Y. Hong, D. M. Jiang, J. H. Li, J. X. Hua, Y. Wang, X. Y. Chen, Y. | World J Gastrointest Oncol | 2024 |
Abdominal cancer |
| Reliability and Validity of the Spanish Adaptation of the Stanford Proxy Test for Delirium in Two Clinical Spanish-Speaking Communities | Infante, S. Behn, A. González, M. Pintor, L. Franco, E. Araya, P. Maldonado, J. R. | J Acad Consult Liaison Psychiatry | 2024 |
Humans |
| Detection of delirium in older patients-A point prevalence study in surgical and non-surgical hospital wards | Instenes, I. Eide, L. S. P. Andersen, H. Fålun, N. Pettersen, T. Ranhoff, A. H. Rudolph, J. L. Steihaug, O. M. Wentzel-Larsen, T. Norekvål, T. M. | Scand J Caring Sci | 2024 |
4at |
| The impact of delirium on clinical and functional outcomes in hospitalized patients with acute coronary syndrome | Ioanna, D. Evangelos, F. John, S. Aikaterini, T. Ioannis, V. Dimitrios, P. Maria, S. | Nurs Crit Care | 2024 |
acute coronary syndrome |
| Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care | Jackson, G. P. Jackson, C. E. Boland, J. W. Featherstone, I. Huang, C. Ogden, M. Sartain, K. Siddiqi, N. Twiddy, M. Pearson, M. Johnson, M. J. | Palliat Med | 2024 |
Humans |
| Diffuse optical tomography for mapping cerebral hemodynamics and functional connectivity in delirium | Jiang, S. Huang, J. Yang, H. Czuma, R. Farley, L. Cohen-Oram, A. Hartney, K. Chechotka, K. Kozel, F. A. Jiang, H. | Alzheimers Dement | 2024 |
acute brain failure |
| Cognitive Training for Reduction of Delirium in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial | Jiang, Y. Xie, Y. Fang, P. Shang, Z. Chen, L. Zhou, J. Yang, C. Zhu, W. Hao, X. Ding, J. Yin, P. Wang, Z. Cao, M. Zhang, Y. Tan, Q. Cheng, D. Kong, S. Lu, X. Liu, X. Sessler, D. I. | JAMA Netw Open | 2024 |
Humans |
| Physical activity may a probably protective factor for postoperative delirium: the PNDABLE study | Kong, J. Lin, X. Wang, B. Xu, S. Wang, Y. Hua, S. Gong, H. Dong, R. Lin, Y. Li, C. Bi, Y. | Front Aging Neurosci | 2024 |
Alzheimer-related biomarkers |
| Effects of Exercise Intervention for the Management of Delirium in Hospitalized Older Adults: A Randomized Clinical Trial | Lozano-Vicario, L. Zambom-Ferraresi, F. Zambom-Ferraresi, F. L. Sáez de Asteasu M Galbete-Jiménez, A. Muñoz-Vázquez Á, J. Cedeno-Veloz, B. A. De la Casa-Marín, A. Ollo-Martínez, I. Fernández-Irigoyen, J. Santamaría, E. San Miguel Elcano, R. Ortiz | J Am Med Dir Assoc | 2024 |
delirium |
| The association between the fibrinogen-to-albumin ratio and delirium after deep brain stimulation surgery in Parkinson's disease | Lu, W. Wang, H. Lin, S. Chang, X. Wang, J. Wu, X. Yu, X. | Front Med (Lausanne) | 2024 |
Parkinson’s disease |
| The Application Value of Esketamine and Dexmedetomidine in Preventing Postoperative Delirium and Hyperalgesia in Elderly Patients with Thoracic Anesthesia | Lu, Y. Yin, G. Jin, C. Gu, K. Bao, D. Xu, W. Yang, Z. | Altern Ther Health Med | 2024 |
Humans |
| A Molecular Framework for Delirium | Lyman, K. A. | Neurohospitalist | 2024 |
attention |
| Evaluation of Delirium Among Elders in the Emergency Department: A Cross-Sectional Study | Marcomini, I. Pisoni, L. Mellino, A. Labaran, R. Milani, L. | Dimens Crit Care Nurs | 2024 |
Humans |
| A Mediation Analysis Examining High Risk, Anticholinergic Medication Use, Delirium, and Dementia After Major Surgery | Mohanty, S. Lindroth, H. Timsina, L. Holler, E. Jenkins, P. Ortiz, D. Hur, J. Gillio, A. Zarzaur, B. Boustani, M. | J Surg Res | 2024 |
Anticholinergics |
| Comparing the delirium objective structured clinical examination (OSCE) education package to standard education for post-registration nurses: A randomised controlled trial | Montgomery, A. Smerdely, P. Hickman, L. Traynor, V. | Nurse Educ Today | 2024 |
Delirium |
| Postoperative cognitive dysfunction: Review of pathophysiology, diagnostics and preventive strategies | Nešković, N. Budrovac, D. Kristek, G. Kovačić, B. Škiljić, S. | J Perioper Pract | 2024 |
Neuroinflammation |
| Prognostic implications of delirium after Left Ventricular Assist Device (LVAD) implantation: A retrospective study | Noufi, P. Anderson, K. M. Crowell, N. White, Y. Molina, E. Rao, S. D. Groninger, H. | J Acad Consult Liaison Psychiatry | 2024 |
Delirium |
| Sex Differences in Delirium after Coronary Artery Bypass Graft Surgery and Perioperative Neuropsychiatric Conditions: A Secondary Analysis of a Cohort Study | Oldham, M. A. Kukla, B. Walsh, P. Lee, H. B. | J Geriatr Psychiatry Neurol | 2024 |
coronary artery bypass graft surgery outcomes |
| Incidence of confusional syndrome (delirium) in a Latin American university hospital | Oviedo Lugo, G. F. García Martínez, P. A. Duarte Osorio, A. Rincón, C. J. López, A. Chavarría, R. Pineda Betancur, C. García Gil, N. Duarte Ariza, M. N. Patiño Trejos, J. A. Insignares, J. S. Gómez-Restrepo, C. | Rev Colomb Psiquiatr (Engl Ed) | 2024 |
Cam |
| Postoperative cognitive disorders and delirium in gynecologic surgery: Which surgery and anesthetic techniques to use to reduce the risk? | Pecorella, G. De Rosa, F. Licchelli, M. Panese, G. Carugno, J. T. Morciano, A. Tinelli, A. | Int J Gynaecol Obstet | 2024 |
anesthesia |
| Serum NFL and tau, but not serum UCHL-1 and GFAP or CSF SNAP-25, NPTX2, or sTREM2, correlate with delirium in a 3-year retrospective analysis | Piel, J. H. A. Bargemann, L. Leypoldt, F. Wandinger, K. P. Dargvainiene, J. | Front Neurol | 2024 |
Alzheimer’s disease |
| Age-stratified comorbid and pharmacologic analysis of patients with glioblastoma | Rabin, E. E. Huang, J. Kim, M. Mozny, A. Lauing, K. L. Penco-Campillo, M. Zhai, L. Bommi, P. Mi, X. Power, E. A. Prabhu, V. C. Anderson, D. E. Barton, K. P. Walunas, T. L. Schiltz, G. E. Amidei, C. Sanchez-Gomez, P. Thakkar, J. P. Lukas, R. V. Wainwright, | Brain Behav Immun Health | 2024 |
Confusion |
| Unraveling the Predictors for Delirium and ICU Stay Duration in Patients with Heart Failure and Reduced Ejection Fraction (HFrEF) Undergoing Coronary Artery Bypass Grafting-A Multicentric Analysis | Rustenbach, C. J. Reichert, S. Berger, R. Schano, J. Nemeth, A. Haeberle, H. Charotte, C. Caldonazo, T. Saqer, I. Saha, S. Schnackenburg, P. Djordjevic, I. Krasivskyi, I. Wendt, S. Serna-Higuita, L. M. Doenst, T. Hagl, C. Wahlers, T. Schlensak, C. Sandova | Biomedicines | 2024 |
Cabg |
| Validation of the Delirium Observation Screening Scale in long-term care facilities in Flanders | Sabbe, K. van der Mast, R. Dilles, T. Van Rompaey, B. | Geriatr Gerontol Int | 2024 |
delirium |
| Effect of hospital elder life program on the incidence of delirium: A systematic review and meta-analysis of clinical trials | Shen, H. Liu, X. Wu, L. Jia, J. Jin, X. | Geriatr Nurs | 2024 |
Humans |
| Impact of Delirium Onset and Duration on Mortality in Patients With Cancer Admitted to the ICU | Tao, J. Seier, K. P. Chawla, S. Tan, K. S. Wheeler, A. Sanzone, J. Marasigan-Stone, C. B. Simondac, J. S. Pascual, A. V. Kostelecky, N. T. Voigt, L. P. | J Intensive Care Med | 2024 |
ICU outcomes |
| Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials | Veronese, N. Solimando, L. Bolzetta, F. Maggi, S. Fiedorowicz, J. G. Gupta, A. Fabiano, N. Wong, S. Boyer, L. Fond, G. Dragioti, E. Dominguez, L. J. Barbagallo, M. Romagnoli, S. Bellelli, G. Solmi, M. | Ageing Res Rev | 2024 |
Delirium |
| Study on the causal relationship between educational attainment and delirium: A two-sample Mendelian randomization study | Wan, X. Yu, H. Yang, M. Hou, W. Xie, J. Xu, K. Ma, Y. Ma, R. Wang, F. Xu, P. | Heliyon | 2024 |
Delirium |
| Potential value of serum prealbumin and serum albumin in the identification of postoperative delirium in patients undergoing knee/hip replacement: an observational study and internal validation study | Wang, B. Xin, Y. Tang, X. Wang, F. Hua, S. Yang, Y. Xu, S. Gong, H. Dong, R. Lin, Y. Li, C. Lin, X. Bi, Y. | Front Neurol | 2024 |
biomarkers |
| Understanding the association between pain and delirium in older hospital inpatients: systematic review and meta-analysis | White, N. Bazo-Alvarez, J. C. Koopmans, M. West, E. Sampson, E. L. | Age Ageing | 2024 |
Humans |
| Prognostic value of Geriatric-8 for adverse outcomes within 30 days of surgery in older adults with colorectal cancer: A retrospective cohort study | Winters, A. M. Bakker, J. Ten Hoor, J. Bilo, H. J. G. Roodbol, P. F. Edens, M. A. Finnema, E. J. | Eur J Oncol Nurs | 2024 |
Cognitive decline |
| An online delirium detection tool: Cross-cultural adaptation of a Chinese version of the Family Confusion Assessment Method | Xing, H. Zhu, S. Liu, S. Xia, M. Tong, S. Li, L. Li, L. | Aust Crit Care | 2024 |
Delirium |
| Value of Flemish Version of the Triage Risk Screening Tool in Predicting Unfavorable Outcomes after Elective Cancer Surgery: A Propensity Score-Matched Retrospective Cohort Study | Yajima, S. Nakanishi, Y. Ogasawara, R. A. Imasato, N. Hirose, K. Katsumura, S. Kataoka, M. Masuda, H. | Biomed Hub | 2024 |
Delirium |
| Impact of intraoperative dexmedetomidine on postoperative delirium and pro-inflammatory cytokine levels in elderly patients undergoing thoracolumbar compression fracture surgery: A prospective, randomized, placebo-controlled clinical trial | Ye, C. Shen, J. Zhang, C. Hu, C. | Medicine (Baltimore) | 2024 |
Humans |
| Development and validation of a machine learning model to predict postoperative delirium using a nationwide database: A retrospective, observational study | Yoshimura, M. Shiramoto, H. Koga, M. Morimoto, Y. | J Clin Anesth | 2024 |
Machine learning model |
| Tau and delirium superimposed on dementia: A case report | Yu, P. C. Kuo, C. M. Chen, I. C. | SAGE Open Med Case Rep | 2024 |
Tau |
| Quetiapine Versus Haloperidol in the Management of Hyperactive Delirium: Randomized Controlled Trial | Zakhary, T. Ahmed, I. Luttfi, I. Montasser, M. | Neurocrit Care | 2024 |
Antipsychotics |
| Associations between postoperative cognitive dysfunction, serum interleukin-6 and postoperative delirium among patients after coronary artery bypass grafting: A mediation analysis | Zhang, S. Tao, X. J. Ding, S. Feng, X. W. Wu, F. Q. Wu, Y. | Nurs Crit Care | 2024 |
cardiac surgery |
| Risk prediction models for postoperative delirium in elderly patients with fragility hip fracture: A systematic review and critical appraisal | Zhou, B. Wang, A. Cao, H. | Int J Orthop Trauma Nurs | 2024 |
Humans |
| An exploratory study on the heterogeneity of postoperative delirium: Preoperative cognitive screening does not detect hallucinatory delirium risk | Yajima, S. Nakanishi, Y. Ogasawara, R. A. Imasato, N. Hirose, K. Katsumura, S. Kataoka, M. Masuda, H. | Eur J Surg Oncol | 2024 |
Humans |
| Validation of a viable delirium detection test performed by nurses and physicians during routine patient care | Soboh, R. Gino-Moor, S. Jiris, N. Ginsberg, S. Oliven, R. | BMC Geriatr | 2024 |
Humans |
| Does Comprehensive Geriatric Assessment Reduce the Incidence of Postoperative Delirium? A Quasi-experimental Study in Older Adults Undergoing Transcatheter Aortic Valve Implantation | Schwesinger, A. Tsai, L. T. Lang, W. Mantegazza, N. Bauernschmitt, R. Wilhelm, M. J. Bischoff-Ferrari, H. A. Gagesch, M. | Clin Interv Aging | 2024 |
Humans |
| Butyrylcholinesterase activity in patients with postoperative delirium after cardiothoracic surgery or percutaneous valve replacement- an observational interdisciplinary cohort study | Schlake, K. Teller, J. Hinken, L. Laser, H. Lichtinghagen, R. Schäfer, A. Fegbeutel, C. Weissenborn, K. Jung, C. Worthmann, H. Gabriel, M. M. | BMC Neurol | 2024 |
Aged |
| Diagnostic accuracy of the pediatric CAM-ICU, pre-school CAM-ICU, Pediatric Anesthesia Emergence Delirium and Cornell Assessment of Pediatric Delirium for detecting delirium in the pediatric intensive care unit: A systematic review and meta-analysis | Rohmah, I. Chen, Y. C. Lin, C. J. Tsao, N. H. Chiu, H. Y. | Intensive Crit Care Nurs | 2024 |
Humans |
| Intraoperative Use of Phenylephrine versus Ephedrine and Postoperative Delirium: A Multicenter Retrospective Cohort Study | Ma, H. Ahrens, E. Wachtendorf, L. J. Suleiman, A. Shay, D. Munoz-Acuna, R. Tartler, T. M. Teja, B. Wagner, S. Subramaniam, B. Rhee, J. Schaefer, M. S. | Anesthesiology | 2024 |
Adult |
| Effect of clock rhythm on emergence agitation and early postoperative delirium in older adults undergoing thoracoscopic lung cancer surgery: protocol for a prospective, observational, cohort study | Jiang, L. Wang, J. Chen, W. Wang, Z. Xiong, W. | BMC Geriatr | 2024 |
Humans |
| Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders | Arnsten, A. F. T. Ishizawa, Y. Xie, Z. | Mol Psychiatry | 2023 |
Humans |
| The role of perioperative sedative anesthetics in preventing postoperative delirium: a systematic review and network-meta analysis including 6679 patients | Huang, J. X. Zhang, S. S. Wang, S. X. Xi, D. S. Luo, F. R. Liu, C. J. Li, H. | BMC Cardiovasc Disord | 2024 |
PMID: 38448835 PMCID: PMC10916082 |
| Preventive Effects of Melatonin on Delirium in Intensive Care Unit Patients: A Meta-Analysis of Randomized Controlled Trials | Zhao, L. Feng, Z. Wang, Q. Jiang, Z. Qiu, X. | Altern Ther Health Med | 2024 |
ICU Delirium Melatonin Length of Stay Meta-Analysis Mechanical Ventilation |
| Mitochondrial Dysfunction of Peripheral Platelets as a Predictive Biomarker for Postoperative Delirium in Elderly Patients | Yang, Y. Zhang, W. Liu, Y. Liu, X. Xie, J. Xu, R. Huang, Y. Hao, J. Sun, Y. Gu, X. Ma, Z. | Ann Neurol | 2024 |
Postoperative Delirium Bioenergetic Health Index Surgery Mitochondria MMSE
|
| Effect of Esketamine on Postoperative Delirium in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass: A Randomized Controlled Trial | Xiong, X. Shao, Y. Chen, D. Chen, B. Lan, X. Shi, J. | Anesth Analg | 2024 |
Postoperative Delirium Esketamine Cardiac Valve Replacement Cardiopulmonary Bypass CAM CAM-ICU MMSE |
| Prolonged Hourly Neurologic Examinations are Associated with Increased Delirium and No Discernible Benefit in Mild/Moderate Geriatric Traumatic Brain Injury | Ruiz, R. A. F. Canas, M. Diaz, L. Aldana, J. A. Afzal, H. Falcon, A. F. Del Toro, D. Day, A. McCarthy, J. Stansfield, K. Bochicchio, G. V. Niziolek, G. Kranker, L. M. Rosengart, M. R. Hoofnagle, M. Leonard, J. | J Trauma Acute Care Surg | 2024 |
NeuroChecks Delirium TBI CAM-ICU |
| Association of Intravenous Neostigmine and Anticholinergics or Sugammadex with Postoperative Delirium: A Retrospective Cohort Study | Rössler, J. Abramczyk, E. Paredes, S. Anusic, N. Pu, X. Maheshwari, K. Turan, A. Ruetzler, K. | Anesth Analg | 2024 |
bCAM Postoperative Delirium Sugammadex Neostigmine Anesthesia Noncardiac Surgery |
| Metformin Use in Type 2 Diabetics and Delirium After Noncardiac Surgery: A Retrospective Cohort Analysis | Paredes, S. Harb, A. Rössler, J. Nikoo, M. Z. Ruetzler, K. Turan, A. Pu, X. Sessler, D. I. | Anesth Analg | 2024 |
Type 2 Diabetes CAM-ICU bCAM Postoperative Delirium Metformin
|
| Preoperative Intrathecal Morphine is Associated With Reduced Postoperative Pain, Agitation, and Delirium In Living Donor Kidney Transplantation Recipients | Lee, J. E. Lee, K. W. Gil, E. Park, J. B. Kim, B. J. Kim, H. Y. Kim, G. S. | Transplant Proc | 2024 |
Kidney Transplant Postoperative Delirium Intrathecal Morphine CAM-ICU Postoperative Pain Anesthesia |
| Neuropsychological follow-up of isoflurane sedated intensive care patients: a substudy of a randomized trial | Fuchs, V. F. Simon, H. V. Soldinger, N. Volk, T. Meiser, A. | Minerva Anestesiol | 2024 |
Critical care Isoflurane Propofol Delirium |
| Feasibility and Acceptability of Using Wireless Limited Polysomnography to Capture Sleep Before, During, and After Hospitalization for Patients With Planned Cardiothoracic Surgery | Cordoza, M. L. Anderson, B. J. Cevasco, M. Diamond, J. M. Younes, M. Gerardy, B. Iroegbu, C. Riegel, B. | J Cardiovasc Nurs | 2024 |
Critical Illness Intensive Care Unit Polysomnography Sleep Thoracic Surgery |
| Antipsychotics in the Treatment of Delirium in Critically Ill Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Carayannopoulos, K. L. Alshamsi, F. Chaudhuri, D. Spatafora, L. Piticaru, J. Campbell, K. Alhazzani, W. Lewis, K. | Crit Care Med | 2024 |
Antipsychotic medication Delirium Systematic review Critically Ill Cognitive Impairment Coma |
| Burnout and perceived burden levels related to delirium in physicians and nurses | Yamagata, H. Takihara, T. Kobayashi, R. Hirose, K. Higuchi, K. Miyahara, M. Komatsu, D. | Gen Hosp Psychiatry | 2024 |
Humans |
| Bell's mania as a clinical presentation in a neurosurgical setting from a tertiary care neuropsychiatric hospital in India | Mamtani, H. Utagi, S. Chaurasia, K. K. Reddy, P. V. Arasappa, R. Prasad, C. Srinivas, D. Rao, M. B. Thippeswamy, H. | Indian J Psychiatry | 2024 |
Craniopharyngioma |
| Correlation analysis between plasma biomarkers albumin, fibrinogen, and their ratio with postoperative delirium in patients undergoing non-cardiac surgery: a systematic review and meta-analysis | Lu, Z. Wang, B. Liu, M. Yu, D. Li, J. | Am J Transl Res | 2024 |
Albumin |
| Risk factors for hypoactive delirium in patients with nontraumatic ARDS: a prospective observational study | Lian, F. Li, F. Tang, X. Yuan, Y. | Sci Rep | 2024 |
Humans |