NIDUS Delirium Bibliography

Delirium Bibliography books graphic What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title: An Implementation-Effectiveness Study of a Perioperative Delirium Prevention Initiative for Older Adults

Authors: Donovan, A. L. Braehler, M. R. Robinowitz, D. L. Lazar, A. A. Finlayson, E. Rogers, S. Douglas, V. C. Whitlock, E. L.

Year: 2020

Journal: Anesth Analg

Abstract: BACKGROUND: Postoperative delirium is a common and serious problem for older adults. To better align local practices with delirium prevention consensus guidelines, we implemented a 5-component intervention followed by a quality improvement (QI) project at our institution. METHODS: This hybrid implementation-effectiveness study took place at 2 adult hospitals within a tertiary care academic health care system. We implemented a 5-component intervention: preoperative delirium risk stratification, multidisciplinary education, written memory aids, delirium prevention postanesthesia care unit (PACU) orderset, and electronic health record enhancements between December 1, 2017 and June 30, 2018. This was followed by a department-wide QI project to increase uptake of the intervention from July 1, 2018 to June 30, 2019. We tracked process outcomes during the QI period, including frequency of preoperative delirium risk screening, percentage of “high-risk” screens, and frequency of appropriate PACU orderset use. We measured practice change after the interventions using interrupted time series analysis of perioperative medication prescribing practices during baseline (December 1, 2016 to November 30, 2017), intervention (December 1, 2017 to June 30, 2018), and QI (July 1, 2018 to June 30, 2019) periods. Participants were consecutive older patients (≥65 years of age) who underwent surgery during the above timeframes and received care in the PACU, compared to a concurrent control group <65 years of age. The a priori primary outcome was a composite of perioperative American Geriatrics Society Beers Criteria for Potentially Inappropriate Medication Use (Beers PIM) medications. The secondary outcome, delirium incidence, was measured in the subset of older patients who were admitted to the hospital for at least 1 night. RESULTS: During the 12-month QI period, preoperative delirium risk stratification improved from 67% (714 of 1068 patients) in month 1 to 83% in month 12 (776 of 931 patients). Forty percent of patients were stratified as “high risk” during the 12-month period (4246 of 10,494 patients). Appropriate PACU orderset use in high-risk patients increased from 19% in month 1 to 85% in month 12. We analyzed medication use in 7212, 4416, and 8311 PACU care episodes during the baseline, intervention, and QI periods, respectively. Beers PIM administration decreased from 33% to 27% to 23% during the 3 time periods, with adjusted odds ratio (aOR) 0.97 (95% confidence interval [CI], 0.95-0.998; P = .03) per month during the QI period in comparison to baseline. Delirium incidence was 7.5%, 9.2%, and 8.5% during the 3 time periods with aOR of delirium of 0.98 (95% CI, 0.91-1.05, P = .52) per month during the QI period in comparison to baseline. CONCLUSIONS: A perioperative delirium prevention intervention was associated with reduced administration of Beers PIMs to older adults.

PMID: PMC7669669

Keywords: Aged
Electronic Health Records/ standards
Emergence Delirium/etiology/ prevention & control
Female
Humans
Male
Perioperative Care/methods/ standards
Practice Guidelines as Topic/ standards
Treatment Outcome

Page(s): 1911-1922

Volume: 131

Issue: 6

Total Records Found: 6753, showing 100 per page
Title	Authors	Journal	Year	Keywords
Association Between Level of Arousal and 30-Day Survival in Acutely Ill Older Adults	Garcez, F. B. Jacob-Filho, W. Avelino-Silva, T. J.	J Am Med Dir Assoc	2020	Delirium arousal dementia hospitalization mortality
Drug therapy for delirium in terminally ill adults	Finucane, A. M. Jones, L. Leurent, B. Sampson, E. L. Stone, P. Tookman, A. Candy, B.	Cochrane Database Syst Rev	2020
Delirium in patients with hip fracture is associated with increased heart rate variability	Ernst, G. Watne, L. O. Rostrup, M. Neerland, B. E.	Aging Clin Exp Res	2020	Autonomic nervous system Delirium Heart rate variability Hip fracture
Risk factors for delirium after esophagectomy	Dezube, A. R. Bravo-Iniguez, C. E. Yelamanchili, N. De Leon, L. E. Tarascio, J. Jaklitsch, M. T. Wee, J. O.	J Surg Oncol	2020	delirium esophageal cancer esophagectomy perioperative factors surgical outcomes surgical technique
Delirium in a Tertiary PICU: Risk Factors and Outcomes	Dervan, L. A. Di Gennaro, J. L. Farris, R. W. D. Watson, R. S.	Pediatr Crit Care Med	2020
Validity and Reliability of the Brazilian Portuguese Version of the Pediatric Confusion Assessment Method for the ICU	de Castro, R. E. V. Prata-Barbosa, A. de Magalhaes-Barbosa, M. C. Cunha, Ajlad Cheniaux, E. Smith, H. A. B.	Pediatr Crit Care Med	2020
Outcomes for patients with delirium receiving hospital-in-the-home treatment: An Australian perspective	Chia, J. Eeles, E. M. Tattam, K. Yerkovich, S.	Australas J Ageing	2020	delirium frail elderly home care services hospital-based
A software to prevent delirium in hospitalised older adults: development and feasibility assessment	Alvarez, E. A. Garrido, M. Ponce, D. P. Pizarro, G. Cordova, A. A. Vera, F. Ruiz, R. Fernandez, R. Velasquez, J. D. Tobar, E. Salech, F.	Age Ageing	2020	delirium gerontechnology non-pharmacological interventions prevention software
Cholinesterase alterations in delirium after cardiosurgery: a German monocentric prospective study	Adam, E. H. Haas, V. Lindau, S. Zacharowski, K. Scheller, B.	BMJ Open	2020	acetylcholinesterase butyrylcholinesterase cardiac surgery cholinesterase postoperative delirium
Cornell Assessment of Pediatric Delirium: a valid, rapid, observational tool for screening delirium in the PICU*	Traube, C. Silver, G. Kearney, J. Patel, A. Atkinson, T. M. Yoon, M. J. Halpert, S. Augenstein, J. Sickles, L. E. Li, C. Greenwald, B.	Crit Care Med	2014	Adolescent Age Distribution Child Child, Preschool Cohort Studies Critical Care/methods Delirium/diagnosis/epidemiology Diagnostic and Statistical Manual of Mental Disorders Feasibility Studies Female Humans Infant Infant, Newborn Intensive Care Units, Pediatric Male Mass Screening/*methods Prevalence Psychometrics Reproducibility of Results Sensitivity and Specificity Severity of Illness Index Sex Distribution Young Adult
The Preschool Confusion Assessment Method for the ICU: Valid and Reliable Delirium Monitoring for Critically Ill Infants and Children	Smith, H. A. Gangopadhyay, M. Goben, C. M. Jacobowski, N. L. Chestnut, M. H. Savage, S. Rutherford, M. T. Denton, D. Thompson, J. L. Chandrasekhar, R. Acton, M. Newman, J. Noori, H. P. Terrell, M. K. Williams, S. R. Griffith, K. Cooper, T. J. Ely, E. W. F	Crit Care Med	2016	Child, Preschool Confusion/diagnosis Critical Illness Delirium/diagnosis Female Humans Infant Intensive Care Units, Pediatric Male *Neuropsychological Tests Observer Variation Prospective Studies Reproducibility of Results Respiration, Artificial Sensitivity and Specificity Severity of Illness Index
Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit	Smith, H. A. Boyd, J. Fuchs, D. C. Melvin, K. Berry, P. Shintani, A. Eden, S. K. Terrell, M. K. Boswell, T. Wolfram, K. Sopfe, J. Barr, F. E. Pandharipande, P. P. Ely, E. W.	Crit Care Med	2011	Child Child, Preschool Cohort Studies Confusion/diagnosis Critical Care/methods Critical Illness Delirium/diagnosis Female Humans *Intensive Care Units, Pediatric Male Neuropsychiatry/standards Observer Variation Practice Guidelines as Topic Prospective Studies Psychometrics Reference Standards Reproducibility of Results Risk Assessment Sensitivity and Specificity Severity of Illness Index
Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale	Sikich, N. Lerman, J.	Anesthesiology	2004	Anesthesia Recovery Period Child Confidence Intervals Delirium/diagnosis/psychology Humans Postoperative Complications/diagnosis/*psychology Psychometrics
From Pediatrics to Geriatrics: Toward a Unified Standardized Screening Tool for Delirium: A Thought Experiment	Schieveld, J. N. van Zwieten, J. J.	Crit Care Med	2016	Adult Age Factors Aged Child Delirium/*diagnosis Humans Mass Screening
Diagnostic considerations regarding pediatric delirium: a review and a proposal for an algorithm for pediatric intensive care units	Schieveld, J. N. van der Valk, J. A. Smeets, I. Berghmans, E. Wassenberg, R. Leroy, P. L. Vos, G. D. van Os, J.	Intensive Care Med	2009	Age Factors Algorithms Child Child, Preschool Consciousness Disorders/diagnosis/etiology Critical Care/methods Decision Trees Delirium/*diagnosis/epidemiology/etiology/therapy Diagnosis, Differential Diagnostic and Statistical Manual of Mental Disorders Early Diagnosis Humans Intensive Care Units, Pediatric Pain Measurement Pediatrics/methods Psychiatric Status Rating Scales Psychometrics Risk Assessment/methods Risk Factors Severity of Illness Index Vital Signs
On the utility of diagnostic instruments for pediatric delirium in critical illness: an evaluation of the Pediatric Anesthesia Emergence Delirium Scale, the Delirium Rating Scale 88, and the Delirium Rating Scale-Revised R-98	Janssen, N. J. Tan, E. Y. Staal, M. Janssen, E. P. Leroy, P. L. Lousberg, R. van Os, J. Schieveld, J. N.	Intensive Care Med	2011	Anesthesia Recovery Period Child Critical Illness Delirium/*diagnosis Female Humans Intensive Care Units, Pediatric Male Prospective Studies Psychiatric Status Rating Scales Reproducibility of Results Risk Assessment Severity of Illness Index
Validation of the SOS-PD scale for assessment of pediatric delirium: a multicenter study	Ista, E. van Beusekom, B. van Rosmalen, J. Kneyber, M. C. J. Lemson, J. Brouwers, A. Dieleman, G. C. Dierckx, B. de Hoog, M. Tibboel, D. van Dijk, M.	Crit Care	2018	Adolescent Child Child, Preschool Delirium/classification/diagnosis/mortality Female Humans Infant Male Netherlands Pediatrics/methods/statistics & numerical data Prospective Studies Psychometrics/instrumentation/methods/standards Reproducibility of Results Research Design/standards/statistics & numerical data Assessment tool Benzodiazepine Iatrogenic withdrawal syndrome (IWS) Picu Pediatric delirium Sedation
Sophia Observation withdrawal Symptoms-Paediatric Delirium scale: A tool for early screening of delirium in the PICU	Ista, E. Te Beest, H. van Rosmalen, J. de Hoog, M. Tibboel, D. van Beusekom, B. van Dijk, M.	Aust Crit Care	2018	Adolescent Child Child, Preschool Critical Illness Delirium/diagnosis Humans Infant Intensive Care Units, Pediatric Male Mass Screening/methods Prospective Studies Reproducibility of Results Sensitivity and Specificity Assessment tool Benzodiazepine Iatrogenic withdrawal syndrome (IWS) Picu Paediatric Delirium Sedation
Psychometric evaluation of the Sophia Observation withdrawal symptoms scale in critically ill children	Ista, E. de Hoog, M. Tibboel, D. Duivenvoorden, H. J. van Dijk, M.	Pediatr Crit Care Med	2013	Adolescent Analgesics, Opioid/adverse effects Benzodiazepines/adverse effects Child Child, Preschool Critical Illness Female Hospitals, University Humans Infant Infant, Newborn Intensive Care Units, Pediatric Male Prospective Studies Psychometrics Risk Factors Sensitivity and Specificity Severity of Illness Index Substance Withdrawal Syndrome/diagnosis/psychology
Clinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals	Harris, J. Ramelet, A. S. van Dijk, M. Pokorna, P. Wielenga, J. Tume, L. Tibboel, D. Ista, E.	Intensive Care Med	2016	Child Child, Preschool Consensus Critical Illness Delirium/diagnosis/therapy Emergence Delirium/diagnosis/therapy Humans Hypnotics and Sedatives/therapeutic use Infant Infant, Newborn Intensive Care Units/standards Pain Management/methods Pain Measurement/methods Practice Guidelines as Topic Psychomotor Agitation/diagnosis/drug therapy Stress, Psychological Substance Withdrawal Syndrome/diagnosis/therapy Assessment Delirium Distress Pain Sedation Withdrawal syndrome
Assessment scales for delirium: A review	Grover, S. Kate, N.	World J Psychiatry	2012	Cognition Delirium Diagnosis Screening
Diagnostic accuracy of delirium diagnosis in pediatric intensive care: a systematic review	Daoud, A. Duff, J. P. Joffe, A. R. Alberta Sepsis, Network	Crit Care	2014	Anesthesia/adverse effects Child Delirium/diagnosis/etiology/psychology Humans Intensive Care Units, Pediatric/standards Psychiatric Status Rating Scales/standards
Diagnostic accuracy of delirium diagnosis in pediatric intensive care: a systematic review	Daoud, A. Duff, J. P. Joffe, A. R. Alberta Sepsis, Network	Crit Care	2014	Anesthesia/adverse effects Child Delirium/diagnosis/etiology/psychology Humans Intensive Care Units, Pediatric/standards Psychiatric Status Rating Scales/standards
Delirium is prevalent in older hospital inpatients and associated with adverse outcomes: Results of a prospective multi-centre study on World Delirium Awareness Day	Welch, C. McCluskey, L. Wilson, D. Chapman, G. E. Jackson, T. A. Treml, J. Davis, D. Cunningham, E. Copeland, C. Quinn, T. Pinkney, T. Mahida, R. Nightingale, P. Richardson, S. Todd, O. Willott, R. Torsney, K. Ni Lochlainn, M. Giridharan, K. Cox, N. Masol	BMC Medicine	2019	adult adverse outcome aged article awareness clinical practice delirium female frailty hospital admission hospital patient human length of stay major clinical study male mortality rate observational study prospective study United Kingdom
Olanzapine Versus Haloperidol for Treatment of Delirium in Patients with Advanced Cancer: A Phase III Randomized Clinical Trial	van der Vorst, Mjdl Neefjes, E. C. W. Boddaert, M. S. A. Verdegaal, Batt Beeker, A. Teunissen, S. C. C. Beekman, A. T. F. Wilschut, J. A. Berkhof, J. Zuurmond, W. W. A. Verheul, H. M. W.	Oncologist	2019	Advanced cancer Delirium Efficacy Haloperidol Olanzapine Phase III Safety article.
Diverging Awareness of Postoperative Delirium and Cognitive Dysfunction in German Health Care Providers	Sturm, H. Wildermuth, R. Stolz, R. Bertram, L. Eschweiler, G. W. Thomas, C. Rapp, M. Joos, S.	Clin Interv Aging	2019	Pocd clinical pathways cross-sectoral care delirium prevention dementia postoperative cognitive dysfunction risk screening
An evaluation of the Danish version of the Pediatric Anesthesia Emergence Delirium scale	Simonsen, B. Y. Skovby, P. Lisby, M.	Acta Anaesthesiol Scand	2019
Incidence and Risk Factors for Delirium in Elderly Patients with Critical Limb Ischaemia	Roijers, J. P. Rakke, Y. S. Hopmans, C. J. Buimer, M. G. de Groot, H. G. W. Ho, G. H. Veen, E. J. Mulder, P. G. H. van der Laan, L.	Eur J Vasc Endovasc Surg	2019	Critical limb ischaemia Delirium Risk factors
Initiative for Prevention and Early Identification of Delirium in Medical-Surgical Units: Lessons Learned in the Past Five Years	Rohatgi, N. Weng, Y. Bentley, J. Lansberg, M. G. Shepard, J. Mazur, D. Ahuja, N. Hopkins, J.	Am J Med	2019	Delirium Medical-surgical units Prevention Quality improvement
Elevation of Preoperative Ammonia Level Is Not Associated With the Incidence of Postoperative Delirium in Patients with Liver Transplantation: A Propensity Score Matching Analysis	Ri, H. S. Choi, Y. J. Park, J. Y. Jin, S. J. Lee, Y. S. Son, J. M. Yoon, S. Z. Shin, H. W. Choi, B. H. Lee, T. B.	Transplant Proc	2019
Fluctuations of consciousness after stroke: Associations with the confusion assessment method for the intensive care unit (CAM-ICU) and potential undetected delirium	Reznik, M. E. Daiello, L. A. Thompson, B. B. Wendell, L. C. Mahta, A. Potter, N. S. Yaghi, S. Levy, M. M. Fehnel, C. R. Furie, K. L. Jones, R. N.	J Crit Care	2019	Consciousness Delirium Sepsis Stroke
Postoperative serum albumin decrease independently predicts delirium in elderly subjects after total joint arthroplasty	Qi, J. Liu, C. Chen, L. Chen, J.	Curr Pharm Des	2019	Postoperative delirium albumin elderly risk factor total joint arthroplasty
Dexmedetomidine versus propofol sedation in reducing delirium among older adults in the ICU: A systematic review and meta-analysis	Pereira, J. V. Sanjanwala, R. M. Mohammed, M. K. Le, M. L. Arora, R. C.	Eur J Anaesthesiol	2019
Delirium Rates in Advanced Cancer Patients Admitted to Different Palliative Care Settings: Does It Make the Difference?	Pallotti, M. C. Lopez-Fidalgo Ph, D. J. Biasco, G. Celin, D. Centeno, C. Paragona, M. Moroni, M. Noguera, A.	J Palliat Med	2019	cancer patients course delirium precipitants rates
Randomized Controlled Trial of Enhanced Recovery Program Dedicated to Elderly Patients after Colorectal Surgery	Ostermann, S. Morel, P. Chalé, J. J. Bucher, P. Konrad, B. Meier, R. P. H. Ris, F. Schiffer, E. R. C.	Diseases of the Colon and Rectum	2019	NCT01646190 nasogastric tube amiodarone antibiotic agent anticoagulant agent creatinine opiate adult respiratory distress syndrome advanced cancer aged anus fissure article atrial fibrillation bladder catheterization bleeding blood transfusion body mass cardiopulmonary arrest Charlson Comorbidity Index clinical pathway colorectal surgery constipation controlled study creatinine blood level defecation delirium disseminated intravascular clotting dyspnea elective surgery enhanced recovery after surgery female functional status gastrointestinal hemorrhage geriatrics heart failure heart infarction hematoma high volume hospital hospital readmission human hypovolemic shock ileus incisional hernia infectious complication intestine function intestine obstruction intubation kidney failure larynx edema length of stay lung insufficiency major clinical study male mortality rate multiple organ failure nutritional status open surgery operation duration outcome assessment perioperative period pleura effusion pneumonia postoperative complication postoperative ileus postoperative pain practice guideline preoperative radiotherapy protocol compliance pyelonephritis randomized controlled trial reoperation small intestine obstruction surgical infection surgical stress surgical technique survival prediction thrombocytopenia total parenteral nutrition university hospital urinary tract infection urine retention
The effect of ketamine on emergence agitation in children: A systematic review and meta-analysis	Ng, K. T. Sarode, D. Lai, Y. S. Teoh, W. Y. Wang, C. Y.	Paediatr Anaesth	2019	emergence agitation emergence delirium ketamine meta-analysis pain systematic review
BIS index monitoring and perioperative neurocognitive disorders in older adults: a systematic review and meta-analysis	Miao, M. Xu, Y. Sun, M. Chang, E. Cong, X. Zhang, J.	Aging Clin Exp Res	2019	Bispectral index Meta-analysis Older adults Perioperative neurocognitive disorders Postoperative delirium
Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients	McNeil, J. B. Hughes, C. G. Girard, T. Ware, L. B. Ely, E. W. Chandrasekhar, R. Han, J. H.	PLoS One	2019
Randomized controlled trial of acupuncture to prevent emergence delirium in children undergoing myringotomy tube placement	Martin, C. S. Yanez, N. D. Treggiari, M. M. Piper, L. Cusick, J. Lalwani, K.	Minerva Anestesiol	2019
Detecting delirium in patients with acute stroke: a systematic review of test accuracy	Mansutti, I. Saiani, L. Palese, A.	BMC Neurol	2019	Instruments Intracerebral Haemorrhage Ischaemic stroke Post-stroke delirium Sensitivity Specificity Systematic review Tools
Associations of 4AT with mobility, length of stay and mortality in hospital and discharge destination among patients admitted with hip fractures	Lisk, R. Yeong, K. Enwere, P. Jenkinson, J. Robin, J. Irvin-Sellers, M. Fluck, D. Osmani, A. Sharmin, R. Sharma, P. Fry, C. H. Han, T. S.	Age Ageing	2019	Nhs cognitive function geriatrics health economics older people
Effectiveness of an advanced practice nurse-led delirium education and training programme	Lieow, J. L. M. Chen, F. S. M. Song, G. Tang, P. S. Kowitlawakul, Y. Mukhopadhyay, A.	Int Nurs Rev	2019	Advanced Practice Nurses Critical Care Delirium Screening Education Intensive Care Unit Nursing
Comparison of emergence agitation between succinylcholine and rocuronium-sugammadex in adults following closed reduction of a nasal bone fracture: A prospective randomized controlled trial	Lee, S. J. Sung, T. Y. Cho, C. K.	BMC Anesthesiology	2019	adult article case report clinical article closed reduction (procedure) drug therapy effect size emergence agitation female general anesthesia human incidence male neuromuscular blocking nose fracture outcome assessment prospective study randomized controlled trial risk factor rocuronium sodium chloride sugammadex suxamethonium
Risk factors for post-intensive care syndrome: A systematic review and meta-analysis	Lee, M. Kang, J. Jeong, Y. J.	Aust Crit Care	2019	Intensive care units Meta-analysis Post-intensive care syndrome Risk factors Survivors
Effect of Perioperative Low-Dose Dexmedetomidine on Postoperative Delirium After Living-Donor Liver Transplantation: A Randomized Controlled Trial	Lee, H. Yang, S. M. Chung, J. Oh, H. W. Yi, N. J. Suh, K. S. Oh, S. Y. Ryu, H. G.	Transplant Proc	2019
The Association of Perioperative Serum Lactate Levels with Postoperative Delirium in Elderly Trauma Patients	Lee, C. Lee, J. Cho, H. Song, J. Jung, H. Ma, X. Hwang, J.	BioMed Research International	2019	lactic acid aged article cohort analysis controlled study disease association female hospital admission human injury intensive care unit lactate blood level major clinical study male perioperative period postoperative delirium retrospective study
Frailty defined by 19 items as a predictor of short-term functional recovery in patients with hip fracture	Inoue, T. Misu, S. Tanaka, T. Kakehi, T. Kakiuchi, M. Chuman, Y. Ono, R.	Injury	2019	aged article atrial fibrillation clinical outcome cohort analysis convalescence deep vein thrombosis delirium female frailty Functional Independence Measure functional status assessment hip fracture hospital discharge human major clinical study male Modified Frailty Index multicenter study observational study pneumonia postoperative complication priority journal retrospective study urinary tract infection very elderly
Using language descriptors to recognise delirium: a survey of clinicians and medical coders to identify delirium-suggestive words	Holmes, N. E. Amjad, S. Young, M. Berlowitz, D. J. Bellomo, R.	Crit Care Resusc	2019	Clinical Coding Critical Care/standards Cross-Sectional Studies Delirium/diagnosis Health Knowledge, Attitudes, Practice Humans Intensive Care Units Language Medical Staff/statistics & numerical data Physicians/statistics & numerical data *Surveys and Questionnaires
Diagnostic test accuracy meta-analysis of PRE-DELIRIC (PREdiction of DELIRium in ICu patients): A delirium prediction model in intensive care practice	Ho, M. H. Chen, K. H. Montayre, J. Liu, M. F. Chang, C. C. Traynor, V. Shen Hsiao, S. T. Chang, H. R. Chiu, H. Y.	Intensive Crit Care Nurs	2019	Delirium Diagnostic test Meta-analysis Pre-deliric Sensitivity and specificity
Delirium management: Let's get physical? A systematic review and meta-analysis	Haley, M. N. Casey, P. Kane, R. Y. Darzins, P. Lawler, K.	Australas J Ageing	2019	delirium exercise physical activity physical mobility physical therapy
Delirium post-cardiac surgery: Incidence and associated factors	Habeeb-Allah, A. Alshraideh, J. A.	Nurs Crit Care	2019	associated factors cardiac surgery delirium incidence post-operative delirium
EEG Correlates of Delirium in Children and Young Adults With CD19-Directed CAR T Cell Treatment-Related Neurotoxicity	Gust, J. Annesley, C. E. Gardner, R. A. Bozarth, X.	J Clin Neurophysiol	2019
Process of implementing and delivering the Prevention of Delirium system of care: a mixed method preliminary study	Godfrey, M. Green, J. Smith, J. Cheater, F. Inouye, S. K. Hurst, K. Young, J.	BMC Geriatr	2019	Delirium prevention Hospital care Hospital volunteers Implementation Older people
Association between postoperative delirium and postoperative cerebral oxygen desaturation in older patients after cardiac surgery	Eertmans, W. De Deyne, C. Genbrugge, C. Marcus, B. Bouneb, S. Beran, M. Fret, T. Gutermann, H. Boer, W. Vander Laenen, M. Heylen, R. Mesotten, D. Vanelderen, P. Jans, F.	Br J Anaesth	2019	cardiac surgery cerebral oxygen saturation delirium intensive care unit near-infrared spectroscopy neurological outcome postoperative delirium
Frailty and hospital outcomes within a low socioeconomic population	Clark, S. Shaw, C. Padayachee, A. Howard, S. Hay, K. Frakking, T. T.	QJM	2019
Perioperative outcomes in geriatric patients undergoing hip fracture surgery with different anesthesia techniques: A systematic review and meta-analysis	Chen, D. X. Yang, L. Ding, L. Li, S. Y. Qi, Y. N. Li, Q.	Medicine	2019	Aged Aged, 80 and over Anesthesia/methods/mortality Hip Fractures/mortality/surgery Hospital Mortality Humans Postoperative Complications/mortality
Postoperative delirium is associated with increased plasma neurofilament light	Casey, C. P. Lindroth, H. Mohanty, R. Farahbakhsh, Z. Ballweg, T. Twadell, S. Miller, S. Krause, B. Prabhakaran, V. Blennow, K. Zetterberg, H. Sanders, R. D.	Brain	2019	adult article cognitive defect cohort analysis controlled study dose response female fractional anisotropy hippocampus human human tissue incidence inflammation major clinical study male nerve degeneration nerve injury neurofilament neurotoxicity nuclear magnetic resonance imaging postoperative delirium preoperative evaluation prospective study protein expression radial diffusivity surgical patient white matter biological marker endogenous compound interleukin 8
Differential clinical characteristics, management and outcome of delirium among ward compared with intensive care unit patients	Canet, E. Amjad, S. Robbins, R. Lewis, J. Matalanis, M. Jones, D. Bellomo, R.	Intern Med J	2019	agitation anti-psychotics delirium intensive care unit *ward
An Evaluation of Risperidone Dosing for Pediatric Delirium in Children Less Than or Equal to 2 Years of Age	Campbell, C. T. Grey, E. Munoz-Pareja, J. Manasco, K. B.	Annals of Pharmacotherapy	2019	article child clinical article controlled study delirium drug megadose drug therapy drug withdrawal female human institutional review male outcome assessment pediatric intensive care unit psychosis retrospective study sedation treatment duration university hospital fentanyl ketamine midazolam morphine risperidone
Inpatient Rehabilitation Delirium Screening: Impact on Acute Care Transfers and Functional Outcomes	Bushi, S. Barrett, A. M. Oh-Park, M.	PMR	2019	Acute Care Transfer Delirium Rehabilitation
Routine Management of Postoperative Delirium Outside the ICU: Results of an International Survey among Anaesthesiologists	Bilotta, F. Weiss, B. Neuner, B. Kramer, S. Aldecoa, C. Bettelli, G. Sanders, R. D. Delp, S. M. Spies, C. D.	Acta Anaesthesiol Scand	2019	Postoperative delirium anaesthesiologists practice survey
Impact of delirium on short-term outcomes in hip fracture patients under a program of approach to delirium	Bielza, R. Zambrana, F. Fernandez de la Puente, E. Sanjurjo, J. Andreu, C. Thuissard, I. J. Gomez Cerezo, J.	Geriatr Gerontol Int	2019	delirium dementia orthopedics
Outcome Differences by Delirium Motor Subtype in Patients with Ischemic Stroke	Yang, H. W. Lee, M. Shin, J. W. Jeong, H. S. Kim, J. Kim, J. L.	Psychiatry Investig	2019	Delirium Ischemic stroke Motor subtype Outcomes
Serial Ottawa 3DY assessments to detect delirium in older emergency department community dwellers	Yadav, K. Boucher, V. Carmichael, P. H. Voyer, P. Eagles, D. Pelletier, M. Gouin, E. Daoust, R. Vu, T. T. M. Berthelot, S. Emond, M.	Age Ageing	2019	delirium detection emergency department older people
Development and validation of a postoperative delirium prediction model for patients admitted to an intensive care unit in China: a prospective study	Xing, H. Zhou, W. Fan, Y. Wen, T. Wang, X. Chang, G.	BMJ Open	2019	delirium intensive care models, statistical postoperative
Acute kidney injury as a risk factor of hyperactive delirium: A case control study	Wan, R. McKenzie, C. A. Taylor, D. Camporota, L. Ostermann, M.	J Crit Care	2019	Acute kidney injury Critical care Delirium Intensive care
The Effect of Frailty on Outcome After Vascular Surgery	Visser, L. Banning, L. B. D. El Moumni, M. Zeebregts, C. J. Pol, R. A.	European Journal of Vascular and Endovascular Surgery	2019	adverse outcome aged article body mass Charlson Comorbidity Index clinical evaluation cognition cognitive defect cohort analysis comorbidity comparative study delirium elective surgery female fitness frail elderly frailty functional status functional status assessment Groningen Frailty Indicator health care facility hearing high risk patient hospital discharge hospital readmission human hypertension major clinical study male morbidity mortality rate nutrition observational study outcome assessment people by smoking status physical mobility priority journal prospective study psychosocial disorder sex sex ratio social psychology surgical patient vascular surgery vision
Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions	Vasunilashorn, S. M. Ngo, L. H. Inouye, S. K. Fong, T. G. Jones, R. N. Dillon, S. T. Libermann, T. A. O'Connor, M. Arnold, S. E. Xie, Z. Marcantonio, E. R.	Alzheimers Dement	2019	Apolipoprotein E C-reactive protein Delirium Gene-protein interaction Inflammation
In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium	Vahidy, F. S. Bambhroliya, A. B. Meeks, J. R. Rahman, O. Ely, E. W. Slooter, A. J. C. Tyson, J. E. Miller, C. C. McCullough, L. D. Savitz, S. I. Khan, B.	PLoS One	2019
Reducing delirium and cognitive dysfunction after off-pump coronary bypass: A randomized trial	Szwed, K. Pawliszak, W. Szwed, M. Tomaszewska, M. Anisimowicz, L. Borkowska, A.	Journal of Thoracic and Cardiovascular Surgery	2019	adult artery formation (physiology) article brain clinical outcome complication controlled study coronary artery disease embolism female flooding human incidence major clinical study male neurologic disease off pump coronary surgery post hoc analysis postoperative cognitive dysfunction postoperative delirium randomized controlled trial single blind procedure surgery vein graft carbon dioxide
A randomized control trial comparing prophylactic dexmedetomidine versus clonidine on rates and duration of delirium in older adult patients undergoing coronary artery bypass grafting	Shokri, H. Ali, I.	Journal of Clinical Anesthesia	2019	adult aged analgesia article artificial ventilation body weight bradycardia controlled study coronary artery bypass graft drug therapy extubation female hospital mortality hospitalization human incidence infusion rate inotropism intensive care unit major clinical study male mean arterial pressure morphine addiction mortality rate postoperative delirium prospective study randomized controlled trial sedation surgery university hospital clonidine dexmedetomidine haloperidol morphine
Predisposing and precipitating risk factors for delirium in palliative care patients	Seiler, A. Schubert, M. Hertler, C. Schettle, M. Blum, D. Guckenberger, M. Weller, M. Ernst, J. von Kanel, R. Boettger, S.	Palliat Support Care	2019	Delirium Palliative care patients Palliative treatment Precipitating factors Predisposing factors Risk factors
Preventive effect of dexmedetomidine on postictal delirium after electroconvulsive therapy: A randomised controlled study	Qiu, Z. Zhou, S. Zhang, M. Guo, N. Huang, P. Xiang, P. Hei, Z. Li, X.	Eur J Anaesthesiol	2019
Activity-based occupational therapy intervention for delirium superimposed on dementia in nursing home setting: a feasibility study	Pozzi, C. Lanzoni, A. Lucchi, E. Salimbeni, I. DeVreese, L. P. Bellelli, G. Fabbo, A. Morandi, A.	Aging Clin Exp Res	2019	Delirium Dementia Nursing home Occupational therapy Tailor-made activity
Trials Focusing on Prevention and Treatment of Delirium After Cardiac Surgery: A systematic Review of Randomized Evidence	Pieri, M. De Simone, A. Rose, S. De Domenico, P. Lembo, R. Denaro, G. Landoni, G. Monaco, F.	Journal of Cardiothoracic and Vascular Anesthesia	2019	adult anesthesia cardiopulmonary bypass controlled study double blind procedure Europe female heart surgery human intensive care ischemic preconditioning male Medline North America operating room postoperative delirium prevention randomized controlled trial (topic) review Scopus surgery systematic review dexmedetomidine glucocorticoid inhalation anesthetic agent ketamine local anesthetic agent neuroleptic agent opiate propofol
Association of comt val158met polymorphism with delirium risk and outcomes after traumatic brain injury	Nekrosius, D. Kaminskaite, M. Jokubka, R. Pranckeviciene, A. Lideikis, K. Tamasauskas, A. Bunevicius, A.	Journal of Neuropsychiatry and Clinical Neurosciences	2019	methionine valine adult age alcohol abuse allele article cognition cohort analysis COMT gene delirium female functional status gene genetic association genotype Glasgow coma scale Glasgow Outcome on Discharge Scale human injury severity major clinical study male Montreal cognitive assessment observational study patient monitoring patient risk priority journal prospective study rating scale risk factor single nucleotide polymorphism traumatic brain injury
Anticholinergic burden of long-term medication is an independent risk factor for the development of postoperative delirium: A clinical trial	Mueller, A. Spies, C. D. Eckardt, R. Weiss, B. Pohrt, A. Wernecke, K. D. Schmidt, M.	Journal of Clinical Anesthesia	2019	aged article cancer patient cancer surgery complication controlled study ethics female female genital tract cancer Germany human intervention study major clinical study male non invasive procedure outcome assessment polypharmacy postoperative delirium preoperative evaluation randomized controlled trial risk assessment risk factor university hospital cholinergic receptor blocking agent
Renal function and delirium in older fracture patients: different information from different formulas?	Mossello, E. Rivasi, G. Tortu, V. Giordano, A. Iacomelli, I. Cavallini, M. C. Rafanelli, M. Ceccofiglio, A. Cartei, A. Rostagno, C. Bari, M. D. Ungar, A.	Eur J Intern Med	2019	Creatinine Cystatin C Delirium Glomerular filtration rate
Reversibility of delirium in Ill-hospitalized cancer patients: Does underlying etiology matter?	Matsuda, Y. Maeda, I. Morita, T. Yamauchi, T. Sakashita, A. Watanabe, H. Kaneishi, K. Amano, K. Iwase, S. Ogawa, A. Yoshiuchi, K.	Cancer Med	2019	cancer cause delirium palliative care reversibility
Association Between Perioperative Hypotension and Delirium in Postoperative Critically Ill Patients: A Retrospective Cohort Analysis	Maheshwari, K. Ahuja, S. Khanna, A. K. Mao, G. Perez-Protto, S. Farag, E. Turan, A. Kurz, A. Sessler, D. I.	Anesth Analg	2019
A short delirium caregiver questionnaire for triage of elderly outpatients with cognitive impairment: a development and test accuracy study	Luijendijk, H. J. Quispel-Aggenbach, D. W. P. Stroomer-van Wijk, A. J. M. Meijerink-Blom, A. H. van Walbeek, A. Zuidema, S. U.	International Psychogeriatrics	2019	aged article caregiver cognitive defect controlled study diagnostic test accuracy study disease course emergency health service female gerontopsychiatry hallucination human major clinical study male outcome assessment outpatient patient referral questionnaire sensitivity and specificity sleep telephone
Intraoperative Oxidative Damage and Delirium after Cardiac Surgery	Lopez, M. G. Hughes, C. G. DeMatteo, A. O'Neal, J. B. McNeil, J. B. Shotwell, M. S. Morse, J. Petracek, M. R. Shah, A. S. Brown, N. J. Billings, F. T. th	Anesthesiology	2019
Postoperative delirium after hip surgery is a potential risk factor for incident dementia: A systematic review and meta-analysis of prospective studies	Lee, S. J. Jung, S. H. Lee, S. U. Lim, J. Y. Yoon, K. S. Lee, S. Y.	Arch Gerontol Geriatr	2019	Delirium Dementia Hip fractures Hip replacement Meta-analysis
Evaluation of emergency department derived delirium prediction models using a hospital-wide cohort	Lee, S. Harland, K. Mohr, N. M. Matthews, G. Hess, E. P. Bellolio, M. F. Han, J. H. Weckmann, M. Carnahan, R.	Journal of Psychosomatic Research	2019	aged article cohort analysis controlled study delirium delirium observation screening scale diagnostic test accuracy study emergency ward female hospitalization human ICD-10 ICD-9 major clinical study male model nurse observational study predictive value psychological rating scale retrospective study risk assessment sensitivity and specificity university hospital very elderly
The Practical Use of White Cell Inflammatory Biomarkers in Prediction of Postoperative Delirium after Cardiac Surgery	Kotfis, K. Slozowska, J. Safranow, K. Szylinska, A. Listewnik, M.	Brain Sci	2019	Nlr Plr Pod Pwr biomarkers cardiac surgery delirium prediction index
Characteristics, risk factors and outcome of early-onset delirium in elderly patients with first ever acute ischemic stroke-A prospective observational cohort study	Kotfis, K. Bott-Olejnik, M. Szylińska, A. Listewnik, M. Rotter, I.	Clinical Interventions in Aging	2019	NCT03944694 C reactive protein troponin T aged article atrial fibrillation blood cell ratio brain ischemia clinical feature cohort analysis controlled study delirium disease association female hemianopia hospital admission human incidence major clinical study male mortality neutrophil lymphocyte ratio observational study outcome assessment platelet white blood cell count ratio retrospective study risk factor
Biomarkers of Delirium Duration and Delirium Severity in the ICU	Khan, B. A. Perkins, A. J. Prasad, N. K. Shekhar, A. Campbell, N. L. Gao, S. Wang, S. Khan, S. H. Marcantonio, E. R. Twigg, H. L., 3rd Boustani, M. A.	Crit Care Med	2019
The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile	Hshieh, T. T. Vasunilashorn, S. M. D'Aquila, M. L. Arnold, S. E. Dickerson, B. C. Fong, T. G. Jones, R. N. Marcantonio, E. R. Schmitt, E. M. Xu, G. Gou, Y. Chen, F. Kunze, L. J. Vlassakov, K. V. Abdeen, A. R. Lange, J. K. Earp, B. E. Touroutoglou, A. Carl	Alzheimers Dement	2019	Biomarkers Cerebrospinal fluid Delirium Inflammation Methods Plasma Positron emission tomography Surgery
Clock Drawing Performance Slows for Older Adults after Total Knee Replacement Surgery	Hizel, L. P. Warner, E. D. Wiggins, M. E. Tanner, J. J. Parvataneni, H. Davis, R. Penney, D. L. Libon, D. J. Tighe, P. Garvan, C. W. Price, C. C.	Anesthesia and Analgesia	2019	nct01786577 aged article clock drawing test cognition controlled clinical trial controlled study delirium female human latent period major clinical study male observational study priority journal prospective study total knee arthroplasty
Postoperative delirium after lung resection for primary lung cancer: Risk factors, risk scoring system, and prognosis	Hayashi, K. Motoishi, M. Sawai, S. Horimoto, K. Hanaoka, J.	PLoS One	2019
Intraoperative Low Alpha Power in the Electroencephalogram Is Associated With Postoperative Subsyndromal Delirium	Gutierrez, R. Egaña, J. I. Saez, I. Reyes, F. Briceño, C. Venegas, M. Lavado, I. Penna, A.	Frontiers in Systems Neuroscience	2019	electroencephalograph age aged alpha rhythm anesthesia article assessment of humans clinical article cohort analysis Confusion Assessment Method controlled study delirium delta rhythm electroencephalography female human intraoperative period male minimum lung alveolus concentration Montreal cognitive assessment observational study postoperative delirium power spectrum receiver operating characteristic sensitivity and specificity subsyndromal delirium
Post-operative delirium associated with metabolic alterations following hemi-arthroplasty in older patients	Guo, Y. Li, Y. Zhang, Y. Fang, S. Xu, X. Zhao, A. Zhang, J. Li, J. V. Ma, D. Jia, W. Jiang, W.	Age Ageing	2019	hip fracture metabolomics older patients post-operative delirium
Validation of the Delirium Diagnostic Tool-Provisional (DDT-Pro) With Medical Inpatients and Comparison With the Confusion Assessment Method Algorithm	Franco, J. G. Ocampo, M. V. Velásquez-Tirado, J. D. Zaraza, D. R. Giraldo, A. M. Serna, P. A. López, C. Zuluaga, A. Sepúlveda, E. Kean, J. Trzepacz, P. T.	Journal of Neuropsychiatry and Clinical Neurosciences	2019	administrative personnel adult algorithm article consultation content validity controlled study delirium dementia diagnosis diagnostic accuracy diagnostic test accuracy study disease course DSM-5 female hospital patient human internal consistency interrater reliability major clinical study male neuropsychiatry nurse nursing assessment physician psychological rating scale receiver operating characteristic sensitivity and specificity standard traumatic brain injury
Efficacy and safety of haloperidol for delirium prevention in adult patients: An updated meta-analysis with trial sequential analysis of randomized controlled trials	Chen, Z. Chen, R. Zheng, D. Su, Y. Wen, S. Guo, H. Ye, Z. Deng, Y. Liu, G. Zuo, L. Wei, X. Hou, Y.	Journal of Clinical Anesthesia	2019	adult artificial ventilation Cochrane Library controlled study delirium drug safety drug therapy Embase extrapyramidal symptom female hospitalization human incidence intensive care unit male Medline meta analysis mortality outcome assessment pharmacokinetics prevention prophylaxis QT prolongation quality control randomized controlled trial (topic) review risk factor sequential analysis systematic review Web of Science haloperidol placebo sodium chloride
Change in Serum Level of Interleukin 6 and Delirium After Coronary Artery Bypass Graft	Chen, Y. Lu, S. Wu, Y. Shen, Y. Zhao, H. Ding, S. Feng, X. Sun, L. Tao, X. Li, J. Ma, R. Liu, W. Wu, F. Feng, Y.	Am J Crit Care	2019
Preoperative cardiac function parameters as valuable predictors for nurses to recognise delirium after cardiac surgery: a prospective cohort study	Cai, S. Latour, J. M. Lin, Y. Pan, W. Zheng, J. Xue, Y. Gao, J. Lv, M. Zhang, X. Luo, Z. Wang, C. Zhang, Y.	Eur J Cardiovasc Nurs	2019	Cardiac surgery cardiac function delirium intensive care units predictors
Bedside mental status and outcome in elderly patients admitted for acute coronary syndromes	Briet, C. Blanchart, K. Lemaitre, A. Roux, I. Lavergne, K. Rocamora, A. Bignon, M. Ardouin, P. Sabatier, R. Roule, V. Beygui, F.	Heart	2019	acute coronary syndrome cognitive impairment death delirium elderly outcome grants from Biosensors, Medtronic and Boston Scientific.
Delirium Screening in Aphasic Patients With the Intensive Care Delirium Screening Checklist (ICDSC): A Prospective Cohort Study	Bosselmann, C. Zurloh, J. Stefanou, M. I. Stadler, V. Weber, Y. Lerche, H. Poli, S. Ziemann, U. Mengel, A.	Front Neurol	2019	intensive care delirium screening checklist intracerebral hemorrhage post-stroke aphasia post-stroke delirium stroke
Impact of Frailty on 30-Day Morbidity and Mortality of Patients With Intertrochanteric Femur Fractures	Boissonneault, A. Mener, A. Schwartz, A. Wilson, J. Staley, C. Schenker, M.	Orthopedics	2019
The utility of nursing instruments for daily screening for delirium: Delirium causes substantial functional impairment	Bode, L. Isler, F. Fuchs, S. Marquetand, J. Petry, H. Ernst, J. Schubert, M. Garcia Nunez, D. von Kanel, R. Boettger, S.	Palliat Support Care	2019	Assessment Delirium Electronic Patient Assessment-Acute Care (ePA-AC) Functional impairment Nursing