What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Melatonin does not reduce delirium severity in hospitalized older adults: Results of a randomized placebo-controlled trial
- Authors
- Lange, P. W. Turbić, A. Soh, C. H. Clayton-Chubb, D. Lim, W. K. Conyers, R. Watson, R. Maier, A. B.
- Year
- 2024
- Journal
- J Am Geriatr Soc
- Abstract
BACKGROUND: Delirium is common in older inpatients, causing distress, cognitive decline, and death. Current therapies are unsatisfactory, limited by lack of efficacy and adverse effects. There is an urgent need for effective delirium treatment. Sleep wake cycle is disturbed in delirium; endogenous Melatonin is perturbed, and exogenous Melatonin is a safe and effective medication for sleep disorders. This study aims to determine the effect of oral Melatonin 5 mg immediate release (IR) nightly for five nights on the severity of delirium in older (≥65 years) medical inpatients. METHODS: This was a double-blinded, randomized controlled trial in general internal medicine units of a tertiary teaching hospital. Older inpatients with Confusion Assessment Method positive, hyperactive or mixed delirium within 48 h of admission or onset of in-hospital delirium were included. The primary outcome was change in delirium severity measured with the Memorial Delirium Assessment Scale (MDAS). A previous pilot trial showed 120 participants randomized 1:1 to Melatonin or Placebo would provide 90% power to demonstrate a 3-point reduction in the MDAS. RESULTS: One hundred and twenty participants were randomized, 61 to Melatonin 5 mg and 59 to Placebo. The medication was well tolerated. The mean MDAS improvement was 4.9 (SD 7.6) in the Melatonin group and 5.4 (SD 7.2) in the Placebo group, p-value 0.42, a non-significant difference. A post-hoc analysis showed length of stay (LOS) was shorter in the intervention group (median 9 days [Interquartile Range (IQR) 4, 12] vs. Placebo group 10 [IQR 6, 16] p-value = 0.033, Wilcoxon Rank Sum test). CONCLUSIONS: This trial does not support the hypothesis that Melatonin reduces the severity of delirium. This may be due to no effect of Melatonin, a smaller effect than anticipated, an effect not captured on a multidimensional delirium assessment scale, or a type II statistical error. Melatonin may improve LOS; this hypothesis should be studied.
- PMID
PMID:38438279
- Keywords
aged neurocognitive disorders
delirium
inpatients
melatonin
sepsis-associated encephalopathy
sleep wake disorders
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Adverse events related to physical restraint use in intensive care units: A review of the literature | Berger, S. Grzonka, P. Amacher, S. A. Hunziker, S. Frei, A. I. Sutter, R. | J Intensive Med | 2024 |
Adverse event |
| Managing Postoperative Delirium in Patients Receiving Head and Neck Surgery: An Educational Overview | Babu, S. Kurian Sajith, B. | Clin J Oncol Nurs | 2024 |
Humans |
| Risk Factors for Postoperative Delirium Severity After Deep Brain Stimulation Surgery in Parkinson's Disease | Astalosch, M. Mousavi, M. Ribeiro, L. M. Schneider, G. H. Stuke, H. Haufe, S. Borchers, F. Spies, C. von Hofen-Hohloch, J. Al-Fatly, B. Ebersbach, G. Franke, C. Kühn, A. A. Kübler-Weller, D. | J Parkinsons Dis | 2024 |
Parkinson’s disease |
| A Dual-Camera Eye-Tracking Platform for Rapid Real-Time Diagnosis of Acute Delirium: A Pilot Study | Al-Hindawi, A. Vizcaychipi, M. Demiris, Y. | IEEE J Transl Eng Health Med | 2024 |
Humans |
| Effectiveness of nurse-led non-pharmacological interventions on outcomes of delirium in adults: A meta-analysis of randomized controlled trials | Wang, J. Lu, Y. Chen, X. Wu, Y. | Worldviews Evid Based Nurs | 2024 |
adult health |
| Association of blood glucose change with postoperative delirium after coronary artery bypass grafting in patients with diabetes mellitus: a study of the MIMIC-IV database | Wang, F. Mei, X. | Front Endocrinol (Lausanne) | 2024 |
Humans |
| The genetic relationship between hypotension and delirium: a Mendelian randomization study | Wang, C. Wu, J. Lin, Y. Liu, Z. Liufu, N. Cao, M. | Front Neurol | 2024 |
Mendelian randomization |
| Comparison of Propofol-Based Total Intravenous Anesthesia versus Volatile Anesthesia with Sevoflurane for Postoperative Delirium in Adult Coronary Artery Bypass Grafting Surgery: A Prospective Randomized Single-Blinded Study | Varsha, A. V. Unnikrishnan, K. P. Saravana Babu, M. S. Raman, S. P. Koshy, T. | J Cardiothorac Vasc Anesth | 2024 |
cardiopulmonary bypass |
| Diagnostics and treatment of impulse control disorders, psychosis and delirium: systemic review-based recommendations - guideline "Parkinson's disease" of the German Society of Neurology | Witt, K. Levin, J. van Eimeren, T. Hasan, A. Ebersbach, G. | J Neurol | 2024 |
Delirium |
| Potential mechanism of Taohong Siwu Decoction in preventing and treating postoperative delirium in intertrochanteric fracture patients based on retrospective analysis and network pharmacology | Ding, Z. Yu, Z. Sun, Z. Liu, X. Chen, R. | J Orthop Surg Res | 2024 |
Humans |
| Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery: The ENGAGES-Canada Randomized Clinical Trial | Deschamps, A. Ben Abdallah, A. Jacobsohn, E. Saha, T. Djaiani, G. El-Gabalawy, R. Overbeek, C. Palermo, J. Courbe, A. Cloutier, I. Tanzola, R. Kronzer, A. Fritz, B. A. Schmitt, E. M. Inouye, S. K. Avidan, M. S. | Jama | 2024 |
Postoperative Delirium Anesthesia EEG-guided anesthesia Intraoperative EEG waveform suppression Older Adults |
| Association Between Pupil Light Reflex and Delirium in Adults With Traumatic Brain Injury: Preliminary Findings | Lapierre, A. Proulx, A. Gélinas, C. Dollé, S. Alexander, S. Williamson, D. Bernard, F. Arbour, C. | J Neurosci Nurs | 2024 |
Delirium ICU Delirium Traumatic Brain Injury Pupillary light reflex Postextubation delirium
|
| Prevalence and risk factors of postoperative delirium in tumor patients after free flap reconstruction: A systematic review and meta-analysis of case-control studies | Li, Y. Li, Z. Lv, Q. Gu, Y. Qi, Y. Li, J. Liu, Y. Ma, G. | Surgery | 2024 |
Postoperative Delirium Flap transplantation surgery Risk Factors Proactive prevention measures Systematic Review |
| Risk factors and risk stratification approaches for delirium screening: A Geriatric Emergency Department Guidelines 2.0 systematic review | Seidenfeld, J. Lee, S. Ragsdale, L. Nickel, C. H. Liu, S. W. Kennedy, M. | Acad Emerg Med | 2024 |
Geriatrics Delirium Emergency Department delirium screening Risk factors Delirium risk scores Systematic review |
| Examining the impact of permissibility hypercapnia on postoperative delirium among elderly patients undergoing thoracoscopic-laparoscopic esophagectomy: A single-center investigative study | Song, J. Shao, Y. M. Zhang, G. H. Fan, B. Q. Tao, W. H. Liu, X. F. Huang, X. C. Hu, X. W. | Shock | 2024 |
Postoperative delirium Permissive hypercapnia ventilation thoracic surgery intraoperative respiration |
| Association between modified frailty index and postoperative delirium in patients after cardiac surgery: A cohort study of 2080 older adults | Cheng, H. Ling, Y. Li, Q. Li, X. Tang, Y. Guo, J. Li, J. Wang, Z. Ming, W. K. Lyu, J. | CNS Neurosci Ther | 2024 |
Humans |
| Role of Intraoperative Electroencephalography in Predicting Postoperative Delirium in Patients Undergoing Cardiovascular Surgeries | Al-Qudah, A. M. Sivaguru, S. Anetakis, K. Crammond, D. J. Balzer, J. R. Thirumala, P. D. Subramaniam, K. Sadhasivam, S. Shandal, V. | Clin Neurophysiol | 2024 |
Cardiopulmonary bypass |
| Differences in metalloproteinases and their tissue inhibitors in the cerebrospinal fluid are associated with delirium | Aksnes, M. Schibstad, M. H. Chaudhry, F. A. Neerland, B. E. Caplan, G. Saltvedt, I. Eldholm, R. S. Myrstad, M. Edwin, T. H. Persson, K. Idland, A. V. Pollmann, C. T. Olsen, R. B. Wyller, T. B. Zetterberg, H. Cunningham, E. Watne, L. O. | Commun Med (Lond) | 2024 |
Alzheimer’s disease, Diagnostic markers, Dementia |
| A retrospective cohort study comparing outcomes following hip fractures in Australian indigenous patients with non-Australian indigenous patients | Cheok, T. Bastick, K. George, D. Chan, T. S. Jaitly, A. Jayasekera, N. Bray, L. Poonnoose, P. M. Williams, K. | ANZ J Surg | 2024 |
hip fracture |
| Comparing BIS Monitoring vs. Clinical Assessment for Deep Sedation in the ICU: Effects on Delirium Reduction and Sedative Drug Doses - A randomized trial | Huespe, I. Giunta, D. Acosta, K. Avila, D. Prado, E. Sanghavi, D. Carboni Bisso, I. Giannasi, S. Carini, F. C. | Chest | 2024 |
Bispectral Index,electroencephalogram-based sedation |
| Pharmacologic Management of End-of-Life Delirium: Translating Evidence into Practice | Hui, D. Cheng, S. Y. Paiva, C. E. | Cancers (Basel) | 2024 |
antipsychotic agents |
| Boarding Duration in the Emergency Department and Inpatient Delirium and Severe Agitation | Joseph, J. W. Elhadad, N. Mattison, M. L. P. Nentwich, L. M. Levine, S. A. Marcantonio, E. R. Kennedy, M. | JAMA Netw Open | 2024 |
Humans |
| Boarding Duration in the Emergency Department and Inpatient Delirium and Severe Agitation | Joseph, J. W. Elhadad, N. Mattison, M. L. P. Nentwich, L. M. Levine, S. A. Marcantonio, E. R. Kennedy, M. | JAMA Netw Open | 2024 |
Humans |
| Perioperative Blood Transfusion and Delirium after Total Knee or Hip Arthroplasty: Retrospective Analysis | Kim, S. Oh, T. K. Song, I. A. | J Pers Med | 2024 |
blood trans fusion |
| Randomized feasibility trial for evaluating the impact of primary nursing on delirium duration during intensive care unit stay | Krüger, L. Zittermann, A. Mannebach, T. Wefer, F. Becker, T. Lohmeier, S. Lüttermann, A. von Dossow, V. Rojas, S. V. Gummert, J. Langer, G. | Intensive Crit Care Nurs | 2024 |
Delirium |
| Patient recall of intensive care delirium: A qualitative investigation | la Cour, K. N. Andersen-Ranberg, N. C. Mortensen, C. Poulsen, L. M. Mathiesen, O. Egerod, I. Collet, M. | Acta Anaesthesiol Scand | 2024 |
critical care |
| Sevoflurane multiple Wash In/Wash Out at the end of anesthesia to reduce agitation: A multicenter double-blind randomized controlled trial | Landoni, G. Likhvantsev, V. V. Berikashvili, L. B. Yavorovsky, A. G. Bagdasarov, P. S. Smirnova, A. V. Serkova, T. S. Subbotin, V. V. Kadantseva, K. K. Ovezov, A. M. Yadgarov, M. Y. Yakovlev, A. A. Lamacchia, A. Gallo, L. Gracheva, N. D. Ryzhkov, P. V. Zi | Contemp Clin Trials Commun | 2024 |
Anesthesia |
| Predictive model and discriminant analysis of the development of dementia in patients with delirium in the emergency department | Lupiáñez Seoane, P. Muñoz Negro, J. E. Torres Parejo, U. Gómez Jiménez, F. J. | Semergen | 2024 |
Comorbidity |
| Machine learning for the prediction of delirium in elderly intensive care unit patients | Ma, R. Zhao, J. Wen, Z. Qin, Y. Yu, Z. Yuan, J. Zhang, Y. Wang, A. Li, C. Li, H. Chen, Y. Han, F. Zhao, Y. Sun, S. Ning, X. | Eur Geriatr Med | 2024 |
Delirium |
| A Novel Preoperative Electroencephalogram-Derived Index to Predict Early Postoperative Delirium in Elderly Patients After Hip Fracture Surgeries: Development of a Prediction Model | Nawan, A. Wang, G. Zhao, C. Zhang, W. Jiang, B. Feng, Y. | Geriatr Orthop Surg Rehabil | 2024 |
delirium index |
| Fixed dose ketamine for prehospital management of hyperactive delirium with severe agitation | O'Brien, M. C. Kelleran, K. J. Burnett, S. J. Hausrath, K. A. Kneer, M. S. Nan, N. Ma, C. X. McCartin, R. W. Clemency, B. M. | Am J Emerg Med | 2024 |
Humans |
| Platelet Bioenergetics and Associations With Delirium and Coma in Patients With Sepsis: A Prospective Cohort Study | Onyemekwu, C. A. Prendergast, N. T. Potter, K. M. Toney, N. A. Nouraie, M. S. Shiva, S. Girard, T. D. | CHEST Crit Care | 2024 |
acute brain dysfunction |
| Enhancing European Management of Analgesia, Sedation, and Delirium: A Multinational, Prospective, Interventional Before-After Trial | Paul, N. Grunow, J. J. Rosenthal, M. Spies, C. D. Page, V. J. Hanison, J. Patel, B. Rosenberg, A. von Haken, R. Pietsch, U. Schrag, C. Waydhas, C. Schellongowski, P. Lobmeyr, E. Sander, M. Piper, S. K. Conway, D. Totzeck, A. Weiss, B. | Neurocrit Care | 2024 |
Humans |
| EEG and acute confusional state at the emergency department | Prud'hon, S. Amiel, H. Zanin, A. Revue, E. Kubis, N. Lozeron, P. | Neurophysiol Clin | 2024 |
Humans |
| Preoperative Delirium Risk Screening in Patients Undergoing a Cardiac Surgery: Results from the Prospective Observational FINDERI Study | Sadlonova, M. Hansen, N. Esselmann, H. Celano, C. M. Derad, C. Asendorf, T. Chebbok, M. Heinemann, S. Wiesent, A. Schmitz, J. Bauer, F. E. Ehrentraut, J. Kutschka, I. Wiltfang, J. Baraki, H. von Arnim, C. A. F. | Am J Geriatr Psychiatry | 2024 |
Humans |
| Predicting postoperative delirium after percutaneous transluminal angioplasty and stenting in patients with intracranial atherosclerotic stenosis | Zhu, W. Shen, Y. Zhao, H. Tang, Y. Wang, X. Li, S. | Neurol Res | 2024 |
Postoperative delirium |
| Factors contributing to sepsis-associated encephalopathy: a comprehensive systematic review and meta-analysis | Zhang, Z. Guo, L. Jia, L. Duo, H. Shen, L. Zhao, H. | Front Med (Lausanne) | 2024 |
delirium |
| Impact of delirium intervention on cognitive load among nurses in the intensive care unit: A multi-centre cluster randomized controlled trial | Zhang, S. Ji, M. Cui, W. Wei, J. Ding, S. Wu, Y. | Int J Nurs Pract | 2024 |
Humans |
| Incidence and risk factors of post-operative delirium in glioma patients: A prospective cohort study in general wards | Yuan, C. Cheng, Z. Liu, Y. You, Y. Wang, L. Li, D. Zhong, L. | J Clin Nurs | 2024 |
general ward |
| Effect of Morphine Used to Relieve Dyspnea Due to Heart Failure on Delirium | Yoshikai, S. Ueda, M. Ikeda, K. | J Palliat Med | 2024 |
delirium |
| Association of Delirium with Long-Term Mortality in Critically Ill Patients with COPD Who Survived to Discharge: A Retrospective Cohort Study | Xu, H. B. Xue, F. Ye, Y. Zhang, H. G. | Lung | 2024 |
Copd |
| Effect of obstructive sleep apnea on postoperative delirium: a system review and meta-analysis | Xiao, Y. Li, P. J. Guo, M. Y. Cao, Y. Liang, Z. A. | Sleep Breath | 2024 |
Delirium |
| A qualitative study of geriatric specialist nurses' experiences to navigate delirium in the elderly | Wu, M. Chen, Z. Xu, Y. Zhao, L. Zhao, L. Xia, L. | BMC Nurs | 2024 |
Care |
| The influence of low-dose s-ketamine on postoperative delirium and cognitive function in older adults undergoing thoracic surgery | Wang, Y. Ma, B. Wang, C. Wang, Y. Liu, A. Hang, L. | J Cardiothorac Surg | 2024 |
Humans |
| Neurological diagnostic tests for patients with and without delirium: a prospective observational study | Waefler, N. Abid, I. Montaut, V. Donzé, J. Zender, H. John, G. | Geroscience | 2024 |
CT scan |
| Preoperative cognitive function as a risk factor of postoperative delirium in cancer surgeries: A systematic review and meta-analysis | Varpaei, H. A. Robbins, L. B. Farhadi, K. Bender, C. M. | J Surg Oncol | 2024 |
cancer survivors |
| Role of oral melatonin in prevention of postoperative delirium in patients undergoing elective surgery under general anesthesia: A Randomized controlled trial | Thakur, T. Saini, V. Grover, S. Samra, T. | Indian J Psychiatry | 2024 |
Anxiety |
| Clinical characteristics of delirium in older patients with first-ever acute myocardial infarction who underwent percutaneous coronary intervention : A retrospective study | Tan, J. F. Duan, L. Han, J. C. Cui, J. J. | Herz | 2024 |
Acute myocardial infarction |
| Antibiotics for delirium in older adults with pyuria or bacteriuria: A systematic review | Stall, N. M. Kandel, C. Reppas-Rindlisbacher, C. Quinn, K. L. Wiesenfeld, L. MacFadden, D. R. Johnstone, J. Fralick, M. | J Am Geriatr Soc | 2024 |
antibiotics |
| Establishment and validation of the prediction model for postoperative delirium risk factors in older patients after total knee arthroplasty: A retrospective study | Song, L. X. Qin, Y. Yang, L. Xing, D. B. Li, Y. Lei, F. Q. Wang, L. H. | Medicine (Baltimore) | 2024 |
Humans |
| Predictive value of the Naples prognostic score on postoperative delirium in the elderly with gastrointestinal tumors: a retrospective cohort study | Song, C. Yu, D. Li, Y. Liu, M. Zhang, H. He, J. Li, J. | BMC Geriatr | 2024 |
Humans |
| Effect of prophylactic corticosteroids on postoperative neurocognitive dysfunction in the adult population: An updated systematic review, meta-analysis, and trial sequential analysis of randomised controlled trials | Singh, N. P. Makkar, J. K. Goel, N. Karamchandani, K. Singh, M. Singh, P. M. | Indian J Anaesth | 2024 |
Corticosteroids |
| Usefulness of the 4A's test for detecting delirium in critically ill patients: a multicenter prospective observation study | Sim, J. K. Chung, K. Chung, C. R. Lee, J. Hwang, S. Y. Lee, Y. S. | Intern Emerg Med | 2024 |
Critical illness |
| Incidence of Postoperative Delirium among Elderly Patients after Elective Surgeries under Anesthesia in the Charity Services of the Philippine General Hospital | Hermoso, R. M. L. Cruz, P. L. O. | Acta Med Philipp | 2024 |
elderly |
| Registered nurses' experiences of caring for patients with hypoactive delirium after cardiac surgery - A qualitative study | Hallberg Kristensen, A. Nymark, C. Stenman, M. Falk, A. | Intensive Crit Care Nurs | 2024 |
Cardiac surgical procedures |
| Determinants of delirium in elderly in-patients in a general ward setting in a teaching hospital: A case control study | Geetha, J. Babu, H. George, C. | Ind Psychiatry J | 2024 |
Delirium |
| Incidence and risk factors of delirium following brain tumor resection: A retrospective National Inpatient Sample database study | Fu, W. Li, Y. Liu, R. Li, J. | World Neurosurg | 2024 |
Brain tumor |
| Prolonged hourly neurological examinations are associated with increased delirium and no discernible benefit in mild/moderate geriatric traumatic brain injury | Fonseca, R. A. Canas, M. Diaz, L. Aldana, J. A. Afzal, H. De Filippis, A. Del Toro, D. Day, A. McCarthy, J. Stansfield, K. Bochicchio, G. V. Niziolek, G. Kranker, L. M. Rosengart, M. R. Hoofnagle, M. Leonard, J. | J Trauma Acute Care Surg | 2024 |
Humans |
| Nursing Intervention to Prevent and Manage Delirium in Critically Ill Patients: A Scoping Review | Fernandes, F. Santos, M. Anacleto, A. M. Jerónimo, C. Ferreira, Ó Baixinho, C. L. | Healthcare (Basel) | 2024 |
adult |
| Intraoperative electroencephalogram features related to frailty in older patients: an exploratory prospective observational study | Fang, P. P. Zhang, H. W. Hao, X. X. Shang, Z. X. Li, J. Liu, X. S. | J Clin Monit Comput | 2024 |
Humans |
| Managing Delirium in the Emergency Department: An Updated Narrative Review | Ehrlich, A. Oh, E. S. Ahmed, S. | Curr Geriatr Rep | 2024 |
Confusion |
| A narrative review of the development and performance characteristics of electronic delirium-screening tools | Eeles, E. Tran, D. D. Boyd, J. Tronstad, O. Teodorczuk, A. Flaws, D. Fraser, J. F. Dissanayaka, N. | Aust Crit Care | 2024 |
*Delirium/diagnosis |
| The Role of Neutrophil-to-Lymphocyte Ratio (NLR) in Urosepsis-Associated Delirium | Dragoescu, A. N. Padureanu, V. Stanculescu, A. D. Chiutu, L. Padureanu, R. Andrei, M. Radu, M. A. Mitroi, G. Dragoescu, P. O. | Cureus | 2024 |
diagnostic |
| Does Melatonin Decrease the Use of As-Needed Antipsychotics or Benzodiazepines in Noncritically Ill Hospitalized Patients? A Multicenter Retrospective Cohort Study | Dobry, P. Poparad-Stezar, A. Bacon, O. Boji, S. Giuliano, C. | J Integr Complement Med | 2024 |
Humans |
| Comparison of the frailty index and frailty phenotype and their associations with postoperative delirium incidence and severity | Deiner, S. G. Marcantonio, E. R. Trivedi, S. Inouye, S. K. Travison, T. G. Schmitt, E. M. Hshieh, T. Fong, T. G. Ngo, L. H. Vasunilashorn, S. M. | J Am Geriatr Soc | 2024 |
Humans |
| Frailty index and risk of delirium in hospitalized patients: a two-sample Mendelian randomization study | Chen, Y. Feng, F. Li, Q. Guo, H. Zhang, L. Liu, J. | Front Med (Lausanne) | 2024 |
Mendelian randomization study |
| Enhancing hospice care with psychological support and a nomogram to predict delirium in patients with advanced solid tumors | Chen, J. Huan, J. Chen, C. Xu, W. Jia, A. | Am J Cancer Res | 2024 |
Hospice care |
| The influence of sleep disorders on perioperative neurocognitive disorders among the elderly: A narrative review | Chen, C. Zhai, R. X. Lan, X. Yang, S. F. Tang, S. J. Xiong, X. L. He, Y. X. Lin, J. F. Feng, J. R. Chen, D. X. Shi, J. | Ibrain | 2024 |
insomnia |
| Prevalence of preoperative depression and adverse outcomes in older patients undergoing elective surgery: A systematic review and meta-analysis | Chen, A. An, E. Yan, E. Saripella, A. Khullar, A. Misati, G. Alhamdah, Y. Englesakis, M. Mah, L. Tartaglia, C. Chung, F. | J Clin Anesth | 2024 |
Delirium, older patients |
| Antipsychotic medications and severe sepsis in schizophrenia: A nested case-control study | Chang, C. W. Chen, W. Y. Chen, P. Y. Pan, C. H. Su, S. S. Tsai, S. Y. Chen, C. C. Kuo, C. J. | Aust N Z J Psychiatry | 2024 |
Sepsis |
| Selection of knowledge translation strategies to implement best practices on nonpharmacological prevention of delirium in intensive care unit | Boivin, A. Bérubé, M. | Rech Soins Infirm | 2024 |
Humans |
| Barriers to healthcare professionals recognizing and managing delirium in older adults during a hospital stay: A mixed-methods systematic review | Bianchi, L. A. Harris, R. Fitzpatrick, J. M. | J Adv Nurs | 2024 |
Humans |
| Burden of delirium on mortality and healthcare resource utilization in geriatric patients hospitalized for inflammatory bowel disease | Aldiabat, M. Aleyadeh, W. Rana, T. Ta'ani, O. A. Alahmad, M. Ayoub, M. Jaber, F. Obeidat, A. Numan, L. Manvar, A. Alhuneafat, L. | Proc (Bayl Univ Med Cent) | 2024 |
Geriatrics |
| Prophylactic Minocycline for Delirium in Critically Ill Patients: A Randomized Controlled Trial | Dal-Pizzol, F. Coelho, A. Simon, C. S. Michels, M. Corneo, E. Jeremias, A. Damásio, D. Ritter, C. | Chest | 2024 |
Humans |
| Clinical Significance of the Prognostic Nutritional Index in Predicting Delirium among Critically Ill Patients: A Retrospective Cohort Study | Xu, F. Zhong, X. | Crit Care Res Pract | 2024 |
Delirium Prognostic Nutrition Index ICU Critically ill patients MIMIC IV |
| Impact of Continuous Infusion Ketamine Compared to Continuous Infusion Benzodiazepines on Delirium in the Intensive Care Unit | Vollmer, N. J. Wieruszewski, E. D. Nei, A. M. Mara, K. C. Rabinstein, A. A. Brown, C. S. | J Intensive Care Med | 2024 |
benzodiazepines |
| Preoperative ketamine administration for prevention of postoperative neurocognitive disorders after major orthopedic surgery in elderly patients: A multicenter randomized blinded placebo-controlled trial | Verdonk, F. Lambert, P. Gakuba, C. Nelson, A. C. Lescot, T. Garnier, F. Constantin, J. M. Saurel, D. Lasocki, S. Rineau, E. Diemunsch, P. Dreyfuss, L. Tavernier, B. Bezu, L. Josserand, J. Mebazaa, A. Coroir, M. Nouette-Gaulain, K. Macouillard, G. Glasman, | Anaesth Crit Care Pain Med | 2024 |
Delayed neurocognitive recovery |
| Dexmedetomidine in Palliative Care: A Versatile New Weapon Against Delirium and Pain-Systematic Review | Tavares, T. Almeida, J. Gonçalves, E. Abelha, F. | J Palliat Med | 2024 |
agitation |
| The Effect of Dexmedetomidine as a Local Anesthetic Adjuvant for Iliac Fascia Compartment Block on Postoperative Delirium in Elderly Patients Undergoing Elective Hip Surgery | Liu, X. H. Zhang, Q. F. Zhang, X. Q. Lu, Q. W. Wu, J. H. Gao, X. H. Chen, Z. Y. | Gerontology | 2024 |
Humans |
| Serum NPTX2 as a Potential Predictive Biomarker for Postoperative Delirium in Patients with Acute Type A Aortic Dissection | Liu, W. Wang, Y. Jiang, Y. Lu, S. Zhu, J. Tian, Y. Pan, J. Xu, Z. Wang, D. | Neuropsychiatr Dis Treat | 2024 |
Nptx2 |
| Incidence and risk factors of postoperative delirium following hepatic resection: a retrospective national inpatient sample database study | Liu, R. Liu, N. Suo, S. Yang, Q. Deng, Z. Fu, W. Wang, M. | BMC Surg | 2024 |
Humans |
| Simplified Pain Management Including Fentanyl TTS in PACU Patients With Hip Fracture Surgery to Improve Patients' Well-Being: A Double-Blind Randomized Trial | Labmayr, V. Rief, M. Reinbacher, P. Gebauer, D. Smigaj, J. Sandner-Kiesling, A. Papamargaritis, V. Michaeli, K. Bornemann-Cimenti, H. Schittek, G. A. | J Perianesth Nurs | 2024 |
Humans |
| Preventive Effects of Ramelteon, Suvorexant, and Lemborexant on Delirium in Hospitalized Patients With Physical Disease: A Retrospective Cohort Study | Henmi, R. Nakamura, T. Mashimoto, M. Takase, F. Ozone, M. | J Clin Psychopharmacol | 2024 |
Sleep-inducing drugs Ramelton Suvorexant Lemborexant Delirium Hospitalized patients |
| Delirium detection in the emergency department: A diagnostic accuracy meta-analysis of history, physical examination, laboratory tests, and screening instruments | Carpenter, C. R. Lee, S. Kennedy, M. Arendts, G. Schnitker, L. Eagles, D. Mooijaart, S. Fowler, S. Doering, M. LaMantia, M. A. Han, J. H. Liu, S. W. | Acad Emerg Med | 2024 |
Geriatrics Delirium Screening accuracy Systematic Review Emergency Department |
| Association of preoperative neutrophil-to-lymphocyte ratio with the risk of postoperative delirium in elderly patients undergoing noncardiac surgery: a systematic review and meta-analysis | Zhou, B. Yu, D. D. Xu, X. Wang, J. Li, J. | Psychogeriatrics | 2024 |
neutrophil |
| Peripheral nerve block and cognitive impairment after thoracic surgery: a systematic review and meta-analysis | Zhang, Y. Liu, M. He, J. Zhang, H. Zhang, M. Li, J. | Minerva Anestesiol | 2024 |
Humans |
| Clinical characteristics of older patients with suspected or diagnosed dementia during hospitalization | Yoshino, H. Takechi, H. | Geriatr Gerontol Int | 2024 |
Humans |
| Development of an individualized model for predicting postoperative delirium in elderly patients with hepatocellular carcinoma | Yan, M. Lin, Z. Zheng, H. Lai, J. Liu, Y. Lin, Z. | Sci Rep | 2024 |
Humans |
| The relationship between intraoperative hypothermia and postoperative delirium: The PNDRFAP study | Wang, J. Zhu, L. Li, C. Lin, Y. Wang, B. Lin, X. Bi, Y. | Brain Behav | 2024 |
Humans |
| Interpretable machine learning model for early prediction of delirium in elderly patients following intensive care unit admission: a derivation and validation study | Tang, D. Ma, C. Xu, Y. | Front Med (Lausanne) | 2024 |
Icu |
| Effects of gabapentin on slow-wave sleep period in critically ill adult patients: A randomized controlled trial | Susantitapong, K. Dilokpattanamongkol, P. Sutherasan, Y. Liamsombut, S. Suthisisang, C. | Clin Transl Sci | 2024 |
Humans |
| Association between postoperative hyperactive delirium and major complications in elderly patients undergoing emergency hip fracture surgery: A large-scale cohort study | Sun, M. Chen, W. M. Wu, S. Y. Zhang, J. | Geriatr Gerontol Int | 2024 |
elderly |
| The 4AT scale for rapid detection of delirium in emergency department triage | Soler-Sanchis, A. Martínez-Arnau, F. M. Sánchez-Frutos, J. Pérez-Ros, P. | Front Med (Lausanne) | 2024 |
aged |
| Efficacy and safety of perioperative melatonin for postoperative delirium in patients undergoing surgery: a systematic review and meta-analysis | Shin, H. W. Kwak, J. S. Choi, Y. J. Kim, J. W. You, H. S. Shin, H. J. Jang, Y. K. | J Int Med Res | 2024 |
*Melatonin/therapeutic use/administration & dosage/adverse effects |
| Characterizing medical patients with delirium: A cohort study comparing ICD-10 codes and a validated chart review method | Sheehan, K. A. Shin, S. Hall, E. Mak, D. Y. F. Lapointe-Shaw, L. Tang, T. Marwaha, S. Gandell, D. Rawal, S. Inouye, S. Verma, A. A. Razak, F. | PLoS One | 2024 |
Humans |
| Postoperative Delirium and Dementia in Patients Undergoing Cardiac Surgery: A Review of Randomized Controlled Trials | Shahabi Raberi, V. Solati Kooshk Qazi, M. Zolfi Gol, A. GhorbaniNia, R. Kahourian, O. Faramarz Zadeh, R. | Galen Med J | 2023 |
Cardiac Surgery |
| The association of hemoglobin with postoperative delirium and atrial fibrillation after cardiac surgery: a retrospective sub-study | Sari, S. Brooker, J. Montalvo-Campana, M. Shehata, P. Pu, X. Insler, S. Ruetzler, K. Troianos, C. A. Turan, A. | Braz J Anesthesiol | 2024 |
Humans |
| A novel objective measure for terminal delirium: Activity scores measured by a sheet-type sensor | Otani, H. Yokomichi, N. Imai, K. Toyota, S. Yamauchi, T. Miwa, S. Yuasa, M. Okamoto, S. Kogure, T. Inoue, S. Morita, T. | J Pain Symptom Manage | 2024 |
Agitation |
| A comparison of changes in drug burden index between older inpatients who fell and people who have not fallen: A case-control study | O'Leary, C. E. T. Wilkinson, T. J. Hanger, H. C. | Australas J Ageing | 2024 |
aged |
| Characterizing Ertapenem Neurotoxicity: A Systematic Review and Experience at a Tertiary Medical Center | Mitaka, H. Hasegawa, S. Lan, K. F. Jain, R. Rakita, R. M. Pottinger, P. S. | Open Forum Infect Dis | 2024 |
carbapenems |