What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.
- Authors
- Miller, D. Lewis, S. R. Pritchard, M. W. Schofield-Robinson, O. J. Shelton, C. L. Alderson, P. Smith, A. F.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
BACKGROUND: The use of anaesthetics in the elderly surgical population (more than 60 years of age) is increasing. Postoperative delirium, an acute condition characterized by reduced awareness of the environment and a disturbance in attention, typically occurs between 24 and 72 hours after surgery and can affect up to 60% of elderly surgical patients. Postoperative cognitive dysfunction (POCD) is a new-onset of cognitive impairment which may persist for weeks or months after surgery.Traditionally, surgical anaesthesia has been maintained with inhalational agents. End-tidal concentrations require adjustment to balance the risks of accidental awareness and excessive dosing in elderly people. As an alternative, propofol-based total intravenous anaesthesia (TIVA) offers a more rapid recovery and reduces postoperative nausea and vomiting. Using TIVA with a target controlled infusion (TCI) allows plasma and effect-site concentrations to be calculated using an algorithm based on age, gender, weight and height of the patient.TIVA is a viable alternative to inhalational maintenance agents for surgical anaesthesia in elderly people. However, in terms of postoperative cognitive outcomes, the optimal technique is unknown. OBJECTIVES: To compare maintenance of general anaesthesia for elderly people undergoing non-cardiac surgery using propofol-based TIVA or inhalational anaesthesia on postoperative cognitive function, mortality, risk of hypotension, length of stay in the postanaesthesia care unit (PACU), and hospital stay. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2017, Issue 11), MEDLINE (1946 to November 2017), Embase (1974 to November 2017), PsycINFO (1887 to November 2017). We searched clinical trials registers for ongoing studies, and conducted backward and forward citation searching of relevant articles. SELECTION CRITERIA: We included randomized controlled trials (RCTs) with participants over 60 years of age scheduled for non-cardiac surgery under general anaesthesia. We planned to also include quasi-randomized trials. We compared maintenance of anaesthesia with propofol-based TIVA versus inhalational maintenance of anaesthesia. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed studies for inclusion, extracted data, assessed risk of bias, and synthesized findings. MAIN RESULTS: We included 28 RCTs with 4507 randomized participants undergoing different types of surgery (predominantly cardiovascular, laparoscopic, abdominal, orthopaedic and ophthalmic procedures). We found no quasi-randomized trials. Four studies are awaiting classification because we had insufficient information to assess eligibility.All studies compared maintenance with propofol-based TIVA versus inhalational maintenance of anaesthesia. Six studies were multi-arm and included additional TIVA groups, additional inhalational maintenance or both. Inhalational maintenance agents included sevoflurane (19 studies), isoflurane (eight studies), and desflurane (three studies), and was not specified in one study (reported as an abstract). Some studies also reported use of epidural analgesia/anaesthesia, fentanyl and remifentanil.We found insufficient reporting of randomization methods in many studies and all studies were at high risk of performance bias because it was not feasible to blind anaesthetists to study groups. Thirteen studies described blinding of outcome assessors. Three studies had a high of risk of attrition bias, and we noted differences in the use of analgesics between groups in six studies, and differences in baseline characteristics in five studies. Few studies reported clinical trials registration, which prevented assessment of risk of selective reporting bias.We found no evidence of a difference in incidences of postoperative delirium according to type of anaesthetic maintenance agents (odds ratio (OR) 0.59, 95% confidence interval (CI) 0.15 to 2.26; 321 participants; five studies; very low-certainty evidence); we noted during sensitivity analysis that using different time points in one study may influence direction of this result. Thirteen studies (3215 participants) reported POCD, and of these, six studies reported data that could not be pooled; we noted no difference in scores of POCD in four of these and in one study, data were at a time point incomparable to other studies. We excluded one large study from meta-analysis because study investigators had used non-standard anaesthetic management and this study was not methodologically comparable to other studies. We combined data for seven studies and found low-certainty evidence that TIVA may reduce POCD (OR 0.52, 95% CI 0.31 to 0.87; 869 participants).We found no evidence of a difference in mortality at 30 days (OR 1.21, 95% CI 0.33 to 4.45; 271 participants; three studies; very low-certainty evidence). Twelve studies reported intraoperative hypotension. We did not perform meta-analysis for 11 studies for this outcome. We noted visual inconsistencies in these data, which may be explained by possible variation in clinical management and medication used to manage hypotension in each study (downgraded to low-certainty evidence); one study reported data in a format that could not be combined and we noted little or no difference between groups in intraoperative hypotension for this study. Eight studies reported length of stay in the PACU, and we did not perform meta-analysis for seven studies. We noted visual inconsistencies in these data, which may be explained by possible differences in definition of time points for this outcome (downgraded to very low-certainty evidence); data were unclearly reported in one study. We found no evidence of a difference in length of hospital stay according to type of anaesthetic maintenance agent (mean difference (MD) 0 days, 95% CI -1.32 to 1.32; 175 participants; four studies; very low-certainty evidence).We used the GRADE approach to downgrade the certainty of the evidence for each outcome. Reasons for downgrading included: study limitations, because some included studies insufficiently reported randomization methods, had high attrition bias, or high risk of selective reporting bias; imprecision, because we found few studies; inconsistency, because we noted heterogeneity across studies. AUTHORS’ CONCLUSIONS: We are uncertain whether maintenance with propofol-based TIVA or with inhalational agents affect incidences of postoperative delirium, mortality, or length of hospital stay because certainty of the evidence was very low. We found low-certainty evidence that maintenance with propofol-based TIVA may reduce POCD. We were unable to perform meta-analysis for intraoperative hypotension or length of stay in the PACU because of heterogeneity between studies. We identified 11 ongoing studies from clinical trials register searches; inclusion of these studies in future review updates may provide more certainty for the review outcomes.
- PMID
- Keywords
Aged
Anesthesia, Inhalation
Anesthesia, Intravenous
Anesthetics, Inhalation
Anesthetics, Intravenous/*adverse effects
Cognition/*drug effects
Cognition Disorders/chemically induced
Delirium/chemically induced
Desflurane
Humans
Hypotension/chemically induced
Isoflurane/adverse effects/analogs & derivatives
Methyl Ethers/adverse effects
Middle Aged
Postoperative Complications/chemically induced/mortality
Propofol/*adverse effects
Randomized Controlled Trials as Topic
Sevoflurane
*Surgical Procedures, Operative
- Page(s)
- Volume
- 8
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Assessment of cognition: dementia and delirium : In consideration of the AWMF guidelines 038-013 and 084-002LG | Krupp, S. Iglseder, B. | Z Gerontol Geriatr | 2024 |
Cognitive impairments |
| Retrospective comparison of the effects of remimazolam and dexmedetomidine on postoperative delirium in elderly patients undergoing orthopedic surgery of the lower extremities under spinal anesthesia | Lee, S. Oh, C. Jung, J. Hong, B. Jo, Y. Lee, S. Lim, C. Baek, S. Shin, M. Seo, H. Chung, W. | J Anesth | 2024 |
Benzodiazepines |
| Cluster nursing care based on 10S continuous quality improvement reduces incidence of postoperative delirium in BPH patients | Li, R. X. Liu, J. Jin, P. Ye, X. Q. Xu, S. | Zhonghua Nan Ke Xue | 2024 |
Humans |
| Elderly patients with dysphagia in the intensive care unit: Association between malnutrition and delirium | Liang, X. Li, X. Cheng, H. Wei, F. Li, T. Li, Y. Huang, Y. Lyu, J. Wang, Y. | Nurs Crit Care | 2024 |
critical care nursing |
| Global Research Trends in Postoperative Delirium and Its Risk Factors: A Bibliometric and Visual Analysis | Liu, X. Huangfu, Z. Zhang, X. Ma, T. | J Perianesth Nurs | 2024 |
bibliometrics |
| Intensive care nurses' perceptions and awareness of delirium and delirium prevention guidelines | Meghani, S. Timmins, F. | Nurs Crit Care | 2024 |
Humans |
| Characteristics associated with effectiveness in postoperative delirium research: a systematic review of randomised controlled trials with meta-regression and meta-analysis | Meng, L. Zhao, X. Sun, Y. Cheng, S. Bao, L. Fang, K. Yu, Q. Zheng, Y. Wang, J. Luo, M. Gunderman, D. Vuckovic, N. Sidhu, A. S. Li, J. Li, G. Wolfe, J. W. Liu, Z. Adams, D. C. | Br J Anaesth | 2024 |
Humans |
| Electroencephalography as a tool for assessing delirium in hospitalized patients: A single-center tertiary hospital experience | Mohamad Faizal, N. S. Tan, J. K. Tan, M. M. Khoo, C. S. Sahibulddin, S. Z. Zolkafli, N. Hod, R. Tan, H. J. | J Cent Nerv Syst Dis | 2024 |
Delirium |
| Common molecular and pathophysiological underpinnings of delirium and Alzheimer's disease: molecular signatures and therapeutic indications | Mosharaf, M. P. Alam, K. Gow, J. Mahumud, R. A. Mollah, M. N. H. | BMC Geriatr | 2024 |
Humans |
| Evaluation of postoperative delirium in geriatric patients given acetaminophen with and without melatonin: A retrospective cohort study | Muehrcke, M. N. Blackwelder, R. S. Weeda, E. R. Furlough, L. A. Shelton, J. E. Brace, S. M. Bragg, S. W. | Int J Psychiatry Med | 2024 |
comorbidity |
| Effect of intranasal insulin on perioperative cognitive function in older adults: a randomized, placebo-controlled, double-blind clinical trial | Sun, M. Ruan, X. Zhou, Z. Huo, Y. Liu, M. Liu, S. Cao, J. Liu, Y. H. Zhang, X. Ma, Y. L. Mi, W. | Age Ageing | 2024 |
Humans |
| Predictive model of risk factors for 28-day mortality in patients with sepsis or sepsis-associated delirium based on the MIMIC-IV database | Zhang, L. Li, X. Huang, J. Yang, Y. Peng, H. Yang, L. Yu, X. | Sci Rep | 2024 |
Humans |
| Exploring Causal Links Between Gut Microbiota and Geriatric Syndromes: A Two-Sample Mendelian Randomization Analysis | Yao, Q. Chen, L. Cai, Y. Li, C. Wen, S. Yang, C. Zhang, Q. Zeng, Y. Zheng, S. Zou, J. Huang, G. Zeng, Q. | Int J Med Sci | 2024 |
Humans |
| Intranasal administration of insulin on the incidence of postoperative delirium in middle-aged patients undergoing elective on-pump cardiac surgery (INIPOD-MOPS): a prospective double-blinded randomized control study protocol | Yang, M. Yang, G. Lu, T. Cao, L. Xiao, C. Liang, Y. Ding, J. Jiang, X. Wang, W. Chen, F. Du, Z. Li, H. | Trials | 2024 |
Humans |
| Integrated Multi-Omics Analysis of Cerebrospinal Fluid in Postoperative Delirium | Tripp, B. A. Dillon, S. T. Yuan, M. Asara, J. M. Vasunilashorn, S. M. Fong, T. G. Inouye, S. K. Ngo, L. H. Marcantonio, E. R. Xie, Z. Libermann, T. A. Otu, H. H. | Biomolecules | 2024 |
Humans |
| Sex-stratified analyses of comorbidities associated with an inpatient delirium diagnosis using real world data | Sirota, M. Kodama, L. Woldemariam, S. Tang, A. Li, Y. Kornak, J. Allen, I. E. Raphael, E. Oskotsky, T. | Res Sq | 2024 |
Delirium Older Adults Comorbidities Mental Health Inpatient delirium |
| Reasons influencing the nurses' prioritization process while preventing and managing delirium: findings from a qualitative study | Sist, L. Ugenti, N. V. Chiappinotto, S. Messina, R. Rucci, P. Palese, A. | Aging Clin Exp Res | 2024 |
Humans |
| Clinical and Cognitive Characteristics Associated with the Onset of Delirium in Postoperative Cardiovascular Surgery Patients Admitted to the ICU | Sano, K. Watanabe, A. Kawaguchi, T. Sakamoto, Y. Fukuda, M. | Prog Rehabil Med | 2024 |
Icu |
| Incidence and related risk factors for postoperative delirium following revision total knee arthroplasty: a retrospective nationwide inpatient sample database study | Peng, Z. Wu, J. Wang, Z. Xie, H. Wang, J. Zhang, P. Yang, Q. Luo, Y. | BMC Musculoskelet Disord | 2024 |
Humans |
| Value of the Safety Management System (VMS) frailty instrument as a frailty screener in care for older hospital patients: a systematic review | Oud, F. M. M. Meulman, M. D. Merten, H. Wagner, C. van Munster, B. C. | Eur Geriatr Med | 2024 |
Humans |
| Prediction of Post-Operative Delirium in Older Adults from Preoperative Cognition and Alpha Power from Resting-State EEG | Ning, M. Rodionov, A. Ross, J. M. Ozdemir, R. A. Burch, M. Lian, S. J. Alsop, D. Cavallari, M. Dickerson, B. C. Fong, T. G. Jones, R. N. Libermann, T. A. Marcantonio, E. R. Santarnecchi, E. Schmitt, E. M. Touroutoglou, A. Travison, T. G. Acker, L. Reese, | medRxiv | 2024 |
Postoperative Delirium MoCA Preoperative cognitive function EEG |
| Gabapentinoids-Related Delirium Adverse Events: A Real-World Study from 2004 to 2022 Based on FAERS | Nie, Z. Liang, C. Li, Z. Han, X. Zhang, R. | J Pain Res | 2024 |
Faers |
| TEGEST as promising tool for assessing the risk of perioperative neurocognitive disorders | Nekvindová, K. Ivanová, K. Juríčková, L. Gabrhelík, T. | BMC Geriatr | 2024 |
Humans |
| Incidence and Risk Factors of Developing Post-operative Delirium Among Elderly Patients in a Tertiary Care Hospital: A Retrospective Chart Review | Almashari, Y. Alshaya, R. A. Alenazi, R. R. Alanazi, A. M. Alhanan, R. Al-Shammari, F. A. Muawad, R. | Cureus | 2024 |
anesthesia |
| Predictive factors for the duration of subsyndromal delirium in the intensive care unit | Song, C. Wang, S. Liu, J. Xu, W. Yang, Y. Li, X. | J Clin Nurs | 2024 |
Humans |
| Cognitive and functional change in skilled nursing facilities: Differences by delirium and Alzheimer's disease and related dementias | Saczynski, J. S. Koethe, B. Fick, D. M. Vo, Q. T. Devlin, J. W. Marcantonio, E. R. Briesacher, B. A. | J Am Geriatr Soc | 2024 |
Alzheimer’s disease and related dementias |
| Effects of a Standardized Patient-Based Delirium Care Education Program | Roh, Y. S. Jung, M. J. Issenberg, S. B. | Res Theory Nurs Pract | 2024 |
Humans |
| Hemoglobin level, degree of mobilization, and pneumonia are associated with the development of postoperative delirium in cemented hemiarthroplasty after femoral neck fracture | Riemenschneider, J. Dobrawa, P. Sturm, R. Meier, S. L. Verboket, R. Marzi, I. Störmann, P. | Eur J Trauma Emerg Surg | 2024 |
Complications |
| Assessing Delirium in Patients With Neurological Diseases | Nisgaard, M. G. Boesen, S. V. Jensen, J. | J Neurosci Nurs | 2024 |
Delirium Intensive Care Delirium Screening Checklist Confusion Assessment Method Screening tools Hospital complications
|
| The Approach to Altered Mental Status in the Intensive Care Unit | Albin, C. S. W. Cunha, C. B. Glaser, T. P. Schachter, M. Snow, J. W. Oto, B. | The Approach to Altered Mental Status in the Intensive Care Unit | 2024 |
Altered mental status Intensive care unit Bedside assessment Delirium Review |
| Impact of inhaled sedation on delirium incidence and neurological outcome after cardiac arrest - A propensity-matched control study (Isocare) | Teiten, C. Bailly, P. Tonnelier, J. M. Bodenes, L. de Longeaux, K. L'Her, E. | Resuscitation | 2024 |
Cardiac arrest |
| Delirium care burden of intensive care nurses caring for patients undergoing open-heart surgery: A mixed-method research | Ulus, M. Durmaz Edeer, A. | Nurs Crit Care | 2024 |
caregiver burden |
| Delirium prevalence in emergency department patients: A systematic review and meta-analysis | Wang, Y. Dai, M. Chen, X. Zhang, J. | Nurs Crit Care | 2024 |
acute confusional state |
| Postoperative delirium increases follow-up mortality following hip arthroplasty in older patients with femoral neck fracture | Wu, P. Yang, Y. Yuan, A. Wang, Y. Zhang, Y. | Australas J Ageing | 2024 |
delirium |
| Analysis of risk factors for postoperative delirium in elderly patients undergoing spinal surgery | Zhang, W. P. Chang, W. X. Liu, W. Y. Li, Z. J. Mao, J. W. | Zhongguo Gu Shang | 2024 |
Humans |
| Effect of occupational therapy on the occurrence of delirium in critically ill patients: a systematic review and meta-analysis | Zhao, J. Fan, K. Zheng, S. Xie, G. Niu, X. Pang, J. Zhang, H. Wu, X. Qu, J. | Front Neurol | 2024 |
critically ill patients |
| Serum HMGB1 as a predictor for postoperative delirium in elderly patients undergoing total hip arthroplasty surgery | Zou, Y. Wu, Y. Wei, A. Nie, H. Hui, S. Liu, C. Deng, T. | Adv Clin Exp Med | 2024 |
Hmgb1 |
| The impact of adhering to a quality indicator for sedation, analgesia, and delirium management on costs, revenues, and clinical outcomes in intensive care in Germany: A retrospective observational study | Zuber, A. Rubarth, K. Förster, F. Balzer, F. Spies, C. Fürstenau, D. Kumpf, O. | PLoS One | 2024 |
Humans |
| The association between intraoperative hypotension and postoperative delirium- a retrospective cohort analysis | Zarour, S. Weiss, Y. Abu-Ganim, M. Iacubovici, L. Shaylor, R. Rosenberg, O. Matot, I. Cohen, B. | Anesthesiology | 2024 |
Hypotension Postoperative delirium Elective surgery Elderly Intraoperative Hypotension 4A’s |
| Intensive Care Unit Sleep Promotion Bundle: Impact on Sleep Quality, Delirium, and Other Patient Outcomes | Gorecki, N. M. Prasun, M. A. | Crit Care Nurse | 2024 |
Humans |
| A prospective multi-center study quantifying visual inattention in delirium using generative models of the visual processing stream | Al-Hindawi, A. Vizcaychipi, M. Demiris, Y. | Sci Rep | 2024 |
Humans |
| Correlation of preoperative inflammatory factors and emotional disorders with postoperative delirium in patients with craniocerebral trauma | Cao, P. Jia, Z. Y. Zheng, T. Mei, T. | World J Psychiatry | 2024 |
Inflammatory factors |
| Critical Assessment of the Neurological Complications during High-Risk Anesthesia Procedures | Chaudhary, F. Ahmed, Z. Agrawal, D. K. | J Surg Res (Houst) | 2024 |
Analgesics |
| Association of triglyceride-glucose index and delirium in patients with sepsis: a retrospective study | Fang, Y. Dou, A. Shen, Y. Li, T. Liu, H. Cui, Y. Xie, K. | Lipids Health Dis | 2024 |
Humans |
| The Effects of Appropriate Perioperative Exercise on Perioperative Neurocognitive Disorders: a Narrative Review | Feng, H. Zhang, Z. Lyu, W. Kong, X. Li, J. Zhou, H. Wei, P. | Mol Neurobiol | 2024 |
Humans |
| Spanish Translation and Cultural Adaptation of the Intensive Care Unit Delirium Playbook | Fuentes, A. L. Makhija, H. Fine, J. M. Alicea Reyes, P. Diaz De Leon, B. Sanchez-Azofra, A. Rodriguez-Flores, L. Weston, J. Marquine, M. J. Hu, E. Espinosa-Meza, R. Serafin Higuera, I. R. Vacas Jacques, P. Pollack, D. Novelli, F. Ely, E. W. Malhotra, A. N | ATS Sch | 2024 |
critical illness |
| Predictiveness of preoperative laboratory values for postoperative delirium | Guttenthaler, V. Fidorra, J. Wittmann, M. Menzenbach, J. | Health Sci Rep | 2024 |
older adults |
| Delirium in psychiatric settings: risk factors and assessment tools in patients with psychiatric illness: a scoping review | Huang, C. Wu, B. Chen, H. Tao, H. Wei, Z. Su, L. Wang, L. | BMC Nurs | 2024 |
Delirium |
| Differences of anticholinergic drug burden between older hospitalized patients with and without delirium: a systematic review and meta-analysis based on prospective cohort studies | Ieong, C. Chen, T. Chen, S. Gao, X. Yan, K. He, W. Hong, H. Gu, Y. Chen, X. Yuan, G. | BMC Geriatr | 2024 |
Humans |
| Nursing diagnoses as factors associated with delirium among intensive care unit patients with sepsis: A retrospective correlational study | Ji, H. Oh, E. G. Choi, M. Kim, H. Y. Kim, Y. A. Lee, K. H. | J Adv Nurs | 2024 |
Humans |
| Effectiveness of a delirium risk assessment and multidisciplinary care approach in reducing delirium incidence among surgical intensive care unit patients: A retrospective pre-post intervention study | Hsiao, W. L. Hsieh, P. Y. Hsu, L. F. Lai, Y. H. Wang, M. L. Yeh, Y. C. | J Clin Anesth | 2024 |
Critically ill |
| Incidence of Adverse Events Using Flumazenil in Patients With Iatrogenic Benzodiazepine Delirium: A Retrospective Study | Hieger, M. A. Moore, P. W. Maskell, K. F. | Am J Ther | 2024 |
*Benzodiazepines/adverse effects/antagonists & inhibitors |
| Early Opioid Use and Postoperative Delirium Following Open Abdominal Aortic Aneurysm Repair | Gutierrez, R. D. Pepic, L. Lancaster, E. M. Gasper, W. J. Hiramoto, J. S. Conte, M. S. Bongiovanni, T. Iannuzzi, J. C. | Ann Vasc Surg | 2024 |
Postoperative Delirium Open Abdominal Aortic Aneurysm repair Opioids Oral Morphine Equivalents
|
| Cardio Delirium Day: national study on the prevalence of delirium in Italian cardiology wards | Frongillo, D. Barisone, M. Gilardi, R. Usmiani, T. Falsini, G. | G Ital Cardiol (Rome) | 2024 |
Humans |
| Electroencephalographic Measures of Delirium in the Perioperative Setting: A Systematic Review | Bruzzone, M. J. Chapin, B. Walker, J. Santana, M. Wang, Y. Amini, S. Kimmet, F. Perera, E. Rubinos, C. Arias, F. Price, C. | Anesth Analg | 2024 |
Postoperative Delirium EEG Systematic Review Preoperative delirium prediction
|
| National survey on perioperative cognitive dysfunction | Aldana, E. M. Pérez de Arriba, N. Valverde, J. L. Aldecoa, C. Fábregas, N. Fernández-Candil, J. L. | Rev Esp Anestesiol Reanim (Engl Ed) | 2024 |
Perioperative cognitive dysfunction |
| Standard versus High Cardiopulmonary Bypass Flow Rate: A Randomized Controlled Subtrial Comparing Brain Injury Biomarker Release | Keiller, A. C. Axelsson, M. Bragadottir, G. Lannemyr, L. Wijk, J. Blennow, K. Zetterberg, H. Bagge, R. O. | J Cardiothorac Vasc Anesth | 2024 |
brain injury |
| Olanzapine postinjection delirium/sedation syndrome after long-acting olanzapine depot injection presenting to the emergency department: practical guidelines for diagnosis and management | Kochen, S. A. Hakkers, C. S. van Gorp, F. de Lange, D. W. Haas, L. E. M. | Emerg Med J | 2024 |
accidental |
| Postoperative use of sleep aids and delirium in older adults after major surgery: A retrospective cohort study | Lee, S. B. Park, C. M. Levin, R. Kim, D. H. | J Am Geriatr Soc | 2024 |
pharmacoepidemiology |
| A first assessment of the safe brain initiative care bundle for addressing postoperative delirium in the postanesthesia care unit | Meco, B. C. Jakobsen, K. De Robertis, E. Buhre, W. Alkış, N. Kirkegaard, P. R. Hägi-Pedersen, D. Bubser, F. Koch, S. Evered, L. A. Saunders, S. J. Caterino, M. Paolini, F. Berger-Estilita, J. Radtke, F. M. | J Clin Anesth | 2024 |
Anesthesia |
| Transplantation-Associated Altered Mentation and Encephalopathy: A New Classification for Acute Neurocognitive Changes Associated with Hematopoietic Cell Transplantation from the ASTCT Committee on Practice Guidelines | Meyers, G. Bubalo, J. Eckstrom, E. Winsnes, K. Carpenter, P. A. Artz, A. Lin, R. J. | Transplant Cell Ther | 2024 |
Humans |
| High-risk factors for delirium in severely ill patients and the application of emotional nursing combined with pain nursing | Li, H. R. Guo, Y. | World J Psychiatry | 2024 |
Critical illness |
| Association between antidepressant use and delirium in older adults: an analysis of the World Health Organization's global pharmacovigilance database | Minoc, E. M. Villain, C. Benbrika, S. Chrétien, B. Descatoire, P. Heraudeau, M. Sassier, M. Pierre, M. Martinaud, O. Dolladille, C. Lelong-Boulouard, V. | BMC Geriatr | 2024 |
Humans |
| Educational interventions aimed at improving knowledge of delirium among nursing home staff-a realist review | Molitor, V. Busse, T. S. Giehl, C. Lauer, R. Otte, I. C. Vollmar, H. C. Thürmann, P. Holle, B. Palm, R. | BMC Geriatr | 2024 |
Humans |
| Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial | Nicklas, J. Y. Bergholz, A. Däke, F. Pham, H. H. D. Rabe, M. C. Schlichting, H. Skrovanek, S. Flick, M. Kouz, K. Fischer, M. Olotu, C. Izbicki, J. R. Mann, O. Fisch, M. Schmalfeldt, B. Frosch, K. H. Renné, T. Krause, L. Zöllner, C. Saugel, B. | BJA Open | 2024 |
anaesthesia |
| The utility of the Montreal cognitive assessment (MoCA) in detecting cognitive impairment in surgical populations - A systematic review and meta-analysis | Danquah, M. O. Yan, E. Lee, J. W. Philip, K. Saripella, A. Alhamdah, Y. He, D. Englesakis, M. Chung, F. | J Clin Anesth | 2024 |
Cognitive impairment |
| Bettering Sleep Hygiene to Decrease Delirium and Improve Patient Satisfaction on an Inpatient Oncology Unit | Donovan, T. Vonnes, C. Mason, T. M. | Clin J Oncol Nurs | 2024 |
Humans |
| The effect of fascia iliaca compartment block on postoperative delirium in elder adults undergoing hip surgery: A systematic review and meta-analysis of randomized controlled trials | Duan, R. Cao, L. Zhang, H. Li, P. Wu, X. Li, J. | Int J Orthop Trauma Nurs | 2024 |
Elderly |
| Risk factors and prediction model of delirium in elderly patients after hip arthroplasty | Duan, Y. Zhang, R. | Pak J Med Sci | 2024 |
Delirium |
| Delirium prevalence and delirium literacy across Italian hospital wards: a secondary analysis of data from the World Delirium Awareness Day 2023 | Ornago, A. M. Pinardi, E. Okoye, C. Mazzola, P. Ferrara, M. C. Finazzi, A. Nydahl, P. von Haken, R. Lindroth, H. Liu, K. Morandi, A. Bellelli, G. | Eur Geriatr Med | 2024 |
Delirium |
| Association of postoperative delirium with hypotension in critically ill patients after cardiac surgery: a prospective observational study | Othman, S. M. A. Aziz, M. A. A. Al-Mushiki, G. M. A. Sriwayyapram, C. Okubai, T. Al-Muwaffaq, G. Xu, Q. Alqudaimi, M. | J Cardiothorac Surg | 2024 |
Humans |
| Cerebral autoregulation-directed optimal blood pressure management reduced the risk of delirium in patients with septic shock | Peng, Q. Liu, X. Ai, M. Huang, L. Li, L. Liu, W. Zhao, C. Hu, C. Zhang, L. | J Intensive Med | 2024 |
Cerebral regional oxygen saturation |
| From Traditional Typing to Intelligent Insights: A Narrative Review of Directions Toward Targeted Therapies in Delirium | Potter, K. M. Prendergast, N. T. Boyd, J. G. | Crit Care Med | 2024 |
Humans |
| Associations of serum lactate and lactate clearance with delirium in the early stage of ICU: a retrospective cohort study of the MIMIC-IV database | Qian, X. Sheng, Y. Jiang, Y. Xu, Y. | Front Neurol | 2024 |
Mimic-iv |
| Delirium management in perioperative geriatric services: a narrative review of non-pharmaceutical strategies | Travers, R. Gagliardi, G. Ramseyer, M. | Front Psychiatry | 2024 |
case management |
| Decreased DTI-ALPS index in delirium: a preliminary MRI study | Tu, Y. Song, R. Xiong, F. Fu, X. | Neuroradiology | 2024 |
Dti-alps |
| Association between preoperative persistent hyperglycemia and postoperative delirium in geriatric hip fracture patients | Wang, W. Zhang, Y. Yao, W. Tang, W. Li, Y. Sun, H. Ding, W. | BMC Geriatr | 2024 |
Humans |
| Impact of a Delirium Protocol on Deliriogenic Medication Use in Hospitalized Older Veterans | Weygint, A. M. LaMarr, B. Lee, S. | Sr Care Pharm | 2024 |
Humans |
| Quetiapine Twice Daily Versus Bedtime Dosing in the Treatment of ICU Delirium | Hawthorne, A. Delgado, E. Battle, A. Norton, C. | J Pharm Pract | 2024 |
Humans |
| Epigenetic signals associated with delirium replicated across four independent cohorts | Nishizawa, Y. Thompson, K. C. Yamanashi, T. Wahba, N. E. Saito, T. Marra, P. S. Nagao, T. Nishiguchi, T. Shibata, K. Yamanishi, K. Hughes, C. G. Pandharipande, P. Cho, H. Howard, M. A., 3rd Kawasaki, H. Toda, H. Kanazawa, T. Iwata, M. Shinozaki, G. | Transl Psychiatry | 2024 |
Humans |
| The Genome-wide DNA methylation changes in gastrointestinal surgery patients with and without postoperative delirium: Evidence of immune process in its pathophysiology | Nishizawa, Y. Yamanashi, T. Nishiguchi, T. Kajitani, N. Miura, A. Matsuo, R. Tanio, A. Yamamoto, M. Sakamoto, T. Fujiwara, Y. Thompson, K. Malicoat, J. Yamanishi, K. Seki, T. Kanazawa, T. Iwata, M. Shinozaki, G. | J Psychiatr Res | 2024 |
DNA methylation |
| Retinal imaging with hand-held optical coherence tomography in older people with or without postoperative delirium after hip fracture surgery: A feasibility study | Noah, A. M. Spendlove, J. Tu, Z. Proudlock, F. Constantinescu, C. S. Gottlob, I. Auer, D. P. Dineen, R. A. Moppett, I. K. | PLoS One | 2024 |
Humans |
| A world-wide study on delirium assessments and presence of protocols | Nydahl, P. Liu, K. Bellelli, G. Benbenishty, J. van den Boogaard, M. Caplan, G. Chung, C. R. Elhadi, M. Gurjar, M. Heras-La Calle, G. Hoffmann, M. Jeitziner, M. M. Krewulak, K. Mailhot, T. Morandi, A. Nawa, R. K. Oh, E. S. Collet, M. O. Paulino, M. C. Lin | Age Ageing | 2024 |
Humans |
| The interrelationship between multiple long-term conditions (MLTC) and delirium: a scoping review | Richardson, S. J. Cropp, A. D. Ellis, S. W. Gibbon, J. Sayer, A. A. Witham, M. D. | Age Ageing | 2024 |
Adult |
| Experiences of healthcare staff caring for hospitalised people with delirium: a qualitative systematic review | Siostrom, K. Snowdon, D. Sriamareswaran, R. K. Law, Y. M. Jolliffe, L. Moran, C. | Age Ageing | 2024 |
Humans |
| Nurses prioritization processes to prevent delirium in patients at risk: Findings from a Q-Methodology study | Sist, L. Pezzolati, M. Ugenti, N. V. Cedioli, S. Messina, R. Chiappinotto, S. Rucci, P. Palese, A. | Geriatr Nurs | 2024 |
Humans |
| Effect of near-infrared spectroscopy on postoperative delirium in cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis | Sun, Q. Wu, W. | Front Cardiovasc Med | 2024 |
cardiac surgery |
| Outcomes associated with postoperative cognitive dysfunction: a systematic review and meta-analysis | Suraarunsumrit, P. Srinonprasert, V. Kongmalai, T. Suratewat, S. Chaikledkaew, U. Rattanasiri, S. McKay, G. Attia, J. Thakkinstian, A. | Age Ageing | 2024 |
Aged |
| Refeeding hypophosphatemia is a common cause of delirium in critically ill patients: A retrospective study | Xu, Y. Qian, Y. Liang, P. Liu, N. Dong, D. Gu, Q. Tang, J. | Am J Med Sci | 2024 |
Consciousness |
| Electroencephalography Monitoring for Preventing Postoperative Delirium and Postoperative Cognitive Decline in Patients Undergoing Cardiothoracic Surgery: A Meta-Analysis | Xue, S. Xu, A. X. Liu, H. Zhang, Y. | Rev Cardiovasc Med | 2024 |
cardiothoracic surgery |
| Occurrence and risk factors for post-stroke delirium: A systematic review and meta-analysis | Zhang, G. B. Li, H. Y. Yu, W. J. Ying, Y. Z. Zheng, D. Zhang, X. K. Wang, Y. G. Shi, G. Z. Huang, H. W. | Asian J Psychiatr | 2024 |
Delirium |
| Description of an individualised delirium intervention in intensive care units for critically ill patients delivered by an artificial intelligence-assisted system: using the TIDieR checklist | Zhang, S. Cui, W. Wu, Y. Ji, M. | J Res Nurs | 2024 |
artificial intelligence |
| Construction and validation of a risk prediction model for postoperative delirium in patients with off‑pump coronary artery bypass grafting | Zhang, Y. Ren, M. Zhai, W. Han, J. Guo, Z. | J Thorac Dis | 2024 |
Off-pump coronary artery bypass grafting (OPCABG) |
| Predicting the Risk of Postoperative Delirium in Elderly Patients Undergoing Hip Arthroplasty: Development and Assessment of a Novel Nomogram | Zhang, Y. Xie, L. J. Wu, R. J. Zhang, C. L. Zhuang, Q. Dai, W. T. Zhou, M. X. Li, X. H. | J Invest Surg | 2024 |
Humans |
| Postoperative delirium risk in patients with hyperlipidemia: A prospective cohort study | Zhao, Y. Zhong, K. Zheng, Y. Xia, X. Lin, X. Kowark, A. Wang, X. Zhang, D. Duan, X. | J Clin Anesth | 2024 |
Cognitive decline |
| Effect of phenylephrine versus ephedrine on the incidence of postoperative delirium in olderly adults undergoing knee arthroplasty under general anesthesia: a single-center trial | Zheng, C. Wang, B. Fu, J. Peng, H. Chen, Y. Hu, X. | Sci Rep | 2024 |
Humans |
| Remimazolam for anesthesia and sedation in cardiac surgery and for cardiac patients undergoing non-cardiac surgery: a systematic-narrative hybrid review | D'Andria Ursoleo, J. Licheri, M. Barucco, G. Losiggio, R. Frau, G. Pieri, M. Monaco, F. | Minerva Anestesiol | 2024 |
Humans |
| Nurses' perceptions of patient pain, delirium, and sedation assessments in the intensive care unit: A qualitative study | Correya, A. Rawson, H. Ockerby, C. Hutchinson, A. M. | Aust Crit Care | 2024 |
Adult intensive care unit |
| Extracellular Vesicle MicroRNAs as Predictive Biomarkers in Postoperative Delirium after Spine Surgery; Preliminary Study | Cho, Y. E. Kim, J. Vorn, R. Cho, H. Baek, W. Park, H. Yun, S. Kim, H. S. Cashion, A. K. Gill, J. Koo, B. N. Lee, H. | J Gerontol A Biol Sci Med Sci | 2024 |
Exosome |
| Trace of delirium after robotic lower abdominal tumor resection at different end-tidal carbon dioxide: a RCT trial | Chen, J. Liang, S. Wei, M. Ma, Y. Bi, T. Liu, Z. Song, Y. Chen, H. Wang, Y. | BMC Anesthesiol | 2024 |
Humans |