What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- The Role of Neutrophil-to-Lymphocyte Ratio (NLR) in Urosepsis-Associated Delirium
- Authors
- Dragoescu, A. N. Padureanu, V. Stanculescu, A. D. Chiutu, L. Padureanu, R. Andrei, M. Radu, M. A. Mitroi, G. Dragoescu, P. O.
- Year
- 2024
- Journal
- Cureus
- Abstract
Introduction Urosepsis is a systemic, dysregulated, inflammatory reaction to a urinary tract infection and can have severe effects on all systems, which can often lead to multi-organ failure and death. Sepsis-associated delirium is a common complication in critically ill patients, contributing to adverse outcomes and prolonged hospital stays. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential biomarker for sepsis severity and prognosis. Material and methods Our study investigates the utility of NLR in the diagnostic strategies for urosepsis-associated delirium in a cohort of 76 patients with sepsis and septic shock admitted to the Intensive Care Unit (ICU). We performed a single-centre retrospective observational study in the Craiova Clinical Emergency Hospital between June and October 2023. Results Patients with urological conditions that were diagnosed with urosepsis included 76 patients. These patients were clustered as follows: a group with delirium (37 patients, 48.7%) and another group without delirium (39 patients, 51.3%). Complete blood count parameters were obtained upon admission, and delirium was assessed using standardized diagnostic criteria. We identified a strong significant positive correlation between elevated NLR values on ICU admission and the development of delirium during hospitalization in urosepsis patients. Receiver operating characteristic (ROC) analysis showed similar diagnostic performance for NLR score. Conclusions The findings suggest that NLR may serve as a valuable biomarker for early detection, risk stratification, and guiding therapeutic interventions in urosepsis-associated delirium, thus improving outcomes in critically ill patients.
- PMID
PMID: 38863776
PMCID: PMC11165295
- Keywords
diagnostic
intensive care unit
management
neutrophil-to-lymphocyte ratio (nlr)
prevention
sepsis
septic shock [ss]
urosepsis-associated delirium
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Efficacy of perioperative dexmedetomidine on postoperative pain and neurocognitive functions in orthopaedic surgery: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials | Zhang, X. Leng, Y. Yuan, X. Yang, Y. Zhou, C. Liu, H. | Int J Surg | 2025 |
orthopedic surgery, postoperative pain, postoperative cognitive dysfunction, dexmedetomidine, postoperative delirium |
| Elevated TDP-43 serum levels associated with postoperative delirium following major cardiac surgery | Simon, C. Graves, O. K. Akeju, O. McKay, T. B. | Brain Behav Immun Health | 2025 |
Postoperative delirium, vulnerable patients, major cardiac surgery, prodromal dementia, TDP-43 |
| Empowering Family Care Partners to Optimize Delirium Care for Persons Living With Dementia | Shrestha, P. Fick, D. M. Susman, A. Akter, N. | Res Gerontol Nurs | 2025 |
Family care partners, caregiver priorities, delirium, dementia, delirium superimposed on dementia |
| Impact of Implantable Hearing Devices on Delirium Risk in Patients with Hearing Loss: A National Database Study | Hambach, B. Patel, J. Nunes, K. Sina, E. M. Llerena, P. Knops, A. Chiffer, R. C. Hunter, J. B. | Otol Neurotol | 2025 |
Delirium, hearing loss, implantable hearing rehabilitation devices |
| Cerebrospinal fluid biomarkers of neuroinflammation and postoperative neurocognitive disorders in patients undergoing orthopedic surgery | Feng, H. Liu, Y. Wang, X. Wang, C. Wang, T. | Int J Surg | 2025 |
Postoperative Neurocognitive Disorders, postoperative complications, recovery, cerebrospinal fluid, biomarkers, orthopedic surgery, |
| What are the experiences and support needs of district nurses caring for terminally ill people with delirium at home? A qualitative study | Arnold, E. Lugton, J. Spiller, J. Finucane, A. | BMC Palliat Care | 2025 |
Humans *Qualitative Research *Delirium/nursing Scotland Female *Terminally Ill/psychology Male Middle Aged Adult Needs Assessment Home Care Services/standards Nurses/psychology Community Confusion Delirious Delirium Detection District nurses Home Management Palliative Prevention Terminal |
| ICU nurses' perceptions on family involvement in delirium care for postoperative cardiac surgery patients: A qualitative study | Azimzadeh, D. Lapierre, A. Bouaouina, Z. Williamson, D. Mailhot, T. Arbour, C. | Intensive Crit Care Nurs | 2025 |
Cardiac surgery Delirium Family involvement Icu Nurse’s perception |
| Efficacy and safety of gastrodin in preventing postoperative delirium following cardiac surgery: a randomized placebo controlled clinical trial | Bai, Y. X. Wu, H. L. Xie, W. L. Li, X. Han, J. J. Liu, J. Chen, S. Q. Yin, P. Dong, N. G. Wu, Q. P. | Crit Care | 2025 |
Humans *Benzyl Alcohols/therapeutic use/adverse effects Female Male *Glucosides/therapeutic use/adverse effects Middle Aged Double-Blind Method Aged *Delirium/prevention & control/etiology *Postoperative Complications/prevention & control Cardiac Surgical Procedures/adverse effects Adult Cardiac surgery Delirium Gastrodin |
| Neuroimaging biomarkers on routine Computed Tomography (CT) after acute stroke and their association with post-stroke delirium: A cohort study | Barugh, A. Farrall, A. Ferguson, K. Shenkin, S. MacLullich, A. Mead, G. | J Stroke Cerebrovasc Dis | 2025 |
Brain imaging Cistern ambiens Computed tomography Delirium Stroke |
| Preoperative prediction models for postoperative delirium in cardiac surgery patients - a scoping review | Blakoe, M. Olsen, D. B. Noergaard, M. W. | Contemp Nurse | 2025 |
cardiac surgery delirium postoperative delirium prediction prognostic |
| A Deep-Learning-Based Approach for Delirium Monitoring in ICU Patients Using Thermograms | Blase, D. Chayeb, O. Chan, P. Y. Leonhardt, S. Lueken, M. | Annu Int Conf IEEE Eng Med Biol Soc | 2024 |
Humans *Delirium/diagnosis *Intensive Care Units *Deep Learning *Thermography/methods Monitoring, Physiologic/methods Male Female Aged Neural Networks, Computer Middle Aged |
| Exploring Post-Anaesthesia Care Unit Nurses' Experiences Post Participation in a Delirium Care for Older People Education Intervention: A Qualitative Study | Bowden, A. Wilson, V. Bresolin, J. Nealon, J. Traynor, V. | Int J Older People Nurs | 2025 |
Humans *Qualitative Research *Delirium/nursing Aged Female Male *Clinical Competence Postanesthesia Nursing Nursing Staff, Hospital/education/psychology Geriatric Nursing/education Postoperative Complications/nursing Middle Aged Adult delirium nursing education nursing practice older people professional development simulation‐based‐education |
| Hemoglobin to red cell distribution width ratio predicts postoperative delirium in older patients undergoing hip fracture surgery: A retrospective cohort study | Cao, X. Zhang, H. Li, Y. Liu, M. He, J. Li, J. | Geriatr Gerontol Int | 2025 |
Humans *Hip Fractures/surgery Male Female Retrospective Studies Aged Aged, 80 and over *Hemoglobins/analysis *Delirium/blood/etiology/diagnosis *Postoperative Complications/blood/diagnosis Predictive Value of Tests *Erythrocyte Indices ROC Curve hemoglobin to red blood cell distribution width ratio hip fracture surgery older patients postoperative delirium risk factor |
| Mapping the Nursing Literature on Postoperative Delirium: A Bibliometric Analysis | Cetinkaya, M. M. Taylan, S. Eti Aslan, F. | J Perianesth Nurs | 2025 |
bibliometric analysis delirium nursing surgery |
| Mapping the Nursing Literature on Postoperative Delirium: A Bibliometric Analysis | Cetinkaya, M. M. Taylan, S. Eti Aslan, F. | J Perianesth Nurs | 2025 |
bibliometric analysis delirium nursing surgery |
| Haloperidol in treating delirium, reducing mortality, and preventing delirium occurrence: Bayesian and frequentist meta-analyses | Cheng, S. L. Hsu, T. W. Kao, Y. C. Yu, C. L. Thompson, T. Carvalho, A. F. Stubbs, B. Tseng, P. T. Hsu, C. W. Yang, F. C. Tu, Y. K. Liang, C. S. | Crit Care | 2025 |
*Haloperidol/therapeutic use/adverse effects Humans *Delirium/drug therapy/prevention & control *Bayes Theorem Antipsychotic Agents/therapeutic use/adverse effects Intensive Care Units/statistics & numerical data Mortality/trends Bayesian meta-analysis Delirium Haloperidol Intensive care unit patients Mortality |
| Delirium management in 2024: A status check and evolution in clinical practice since 2016 | Coolens, O. Kaltwasser, A. Melms, T. Monke, S. Nydahl, P. Pelz, S. von Haken, R. Hasemann, W. | Intensive Crit Care Nurs | 2025 |
Best practice Critical care Culture Delirium Delirium management Encephalopathy |
| Machine Learning-Based Prediction of Delirium and Risk Factor Identification in Intensive Care Unit Patients With Burns: Retrospective Observational Study | Esumi, R. Funao, H. Kawamoto, E. Sakamoto, R. Ito-Masui, A. Okuno, F. Shinkai, T. Hane, A. Ikejiri, K. Akama, Y. Gaowa, A. Park, E. J. Momosaki, R. Kaku, R. Shimaoka, M. | JMIR Form Res | 2025 |
Humans *Delirium/diagnosis/epidemiology *Machine Learning Male Female Middle Aged Retrospective Studies *Intensive Care Units *Burns/complications Risk Factors Adult Aged ROC Curve Risk Assessment/methods Ai artificial intelligence burns delirium intensive care unit machine learning prediction model |
| The perceptions of European geriatricians on the co-occurrence and links between dementia, delirium and frailty | Faherty, M. Curtin, C. Bellelli, G. Brunetti, E. Bo, M. Morandi, A. Cherubini, A. Fedecostante, M. Ferrara, M. C. Coin, A. Shenkin, S. D. Soysal, P. Timmons, S. | Eur Geriatr Med | 2025 |
Attitudes Delirium Dementia Frailty Prevalence Risk factors |
| Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery | Fallon, J. M. Hashemaghaie, M. Peterson, C. E. Tran, D. Wu, S. R. Valdes, J. M. Pedicini, N. M. Adams, M. E. Soltis, M. Mansour, W. Wright, M. C. Raghunathan, K. Treggiari, M. M. Sasannejad, C. Devinney, M. J. | BMJ Open | 2025 |
Humans Double-Blind Method *Azepines/therapeutic use Aged *Triazoles/therapeutic use *Delirium/prevention & control *Postoperative Complications/prevention & control Randomized Controlled Trials as Topic Orexin Receptor Antagonists/therapeutic use/administration & dosage Male Sleep Aids, Pharmaceutical/therapeutic use/administration & dosage Female Sleep/drug effects Clinical Trial Delirium Sleep medicine |
| Efficacy and safety of care bundles in the treatment of delirium in ICU patients: a meta-analysis and systemic review | Fang, D. Zeng, L. Kuang, F. | BMC Nurs | 2025 |
Care bundles Delirium Icu Meta-analysis |
| Delirium prevention in hospices: Opportunities and limitations - A focused ethnography | Featherstone, I. Johnson, M. J. Sheldon, T. Kelley, R. Hawkins, R. Bravington, A. Callin, S. Dixon, R. Obita, G. Siddiqi, N. | Palliat Med | 2025 |
Humans *Delirium/prevention & control *Anthropology, Cultural Male Female Hospices Aged Middle Aged Hospice Care United Kingdom Adult Aged, 80 and over Attitude of Health Personnel Qualitative Research Delirium palliative care |
| Amplitude coupling is altered in delirium of various etiologies: Results from a retrospective multi-center case-control EEG study | Fleischmann, R. Mengel, A. Stam, C. J. Leroy, S. Schneider, P. Slooter, A. J. C. Ehler, J. van Dellen, E. | Clin Neurophysiol | 2025 |
Amplitude-amplitude coupling Connectivity Delirium Electroencephalography Postoperative Stroke |
| Effect size estimates of risk factors for post-intensive care syndrome: A systematic review and meta-analysis | Gao, S. Liang, X. Pan, Z. Zhang, X. Zhang, L. | Intensive Crit Care Nurs | 2025 |
Humans Risk Factors *Intensive Care Units/organization & administration Female Male Critical Care/methods/psychology Critical Illness Intensive care units Meta-analysis Post intensive care syndrome Survivors |
| Health-care staff perspectives in optimising delirium prevention using data-driven interventions | Gokhale, S. Garth, B. Webb-St Mart, M. Taylor, D. Zeps, N. Enticott, J. Teede, H. Reeder, S. | Australas J Ageing | 2025 |
Humans *Delirium/prevention & control/diagnosis *Qualitative Research *Attitude of Health Personnel Interviews as Topic Risk Assessment Male Female Health Knowledge, Attitudes, Practice Health Personnel/psychology Risk Factors data‐driven optimisation delirium prevention health services research learning health system pre‐implementation factors |
| Frailty screening of older patients in emergency departments in Norway | Goll, J. B. Saga, E. Johnsen, B. Hoff, O. M. Martinaityte, I. Halvorsen, D. S. Søvde Å, K. Gundersen, M. D. Wang-Hansen, M. | Tidsskr Nor Laegeforen | 2025 |
Humans Norway/epidemiology Aged Female Aged, 80 and over Male *Emergency Service, Hospital/statistics & numerical data *Frail Elderly/statistics & numerical data *Frailty/diagnosis/epidemiology *Geriatric Assessment/methods Delirium/diagnosis/epidemiology Mass Screening |
| Delirium following mechanical thrombectomy for ischemic stroke - individuals at risk, imaging biomarkers and prognosis | Hahn, M. Brockstedt, L. Gröschel, S. Geschke, K. Grauhan, N. F. Brockmann, M. A. Othman, A. E. Gröschel, K. Uphaus, T. | Front Aging Neurosci | 2025 |
atrophy complications delirium endovascular stroke therapy mechanical thrombectomy prognosis stroke |
| Remifentanil use in critically Ill patients requiring mechanical ventilation is associated with increased delirium-free days: a retrospective study | Haruna, J. Sasaki, A. Kazuma, S. | Int J Emerg Med | 2025 |
Critical illness Delirium Remifentanil |
| Outcomes of Older Adults With Delirium Discharged From the Emergency Department | Howick, A. S. Thao, P. Carpenter, K. P. Boie, M. A. Maia, I. W. A. Mullan, A. F. Bower, S. M. Palmer, A. K. Carpenter, C. R. Liu, S. W. Jeffery, M. M. Bellolio, F. | Ann Emerg Med | 2025 |
Dementia Frailty Geriatrics, delirium Mortality Older adult |
| Association between intraoperative electroencephalograph complexity index and postoperative delirium in elderly patients undergoing orthopedic surgery: a prospective cohort study | Hu, X. Y. Dai, Y. C. Zhu, L. Y. Yang, J. J. Sun, J. Ji, M. H. | J Anesth | 2025 |
Complexity Eeg Electroencephalogram Postoperative delirium |
| Hypnotic drug use and intraoperative fluid balance associated with postoperative delirium following pancreatic surgery: A retrospective, observational, single-center study | Huang, Z. H. Zhang, J. Xu, X. Y. Wang, Y. Lu, X. J. Luo, Y. | PLoS One | 2025 |
Humans Male Female Retrospective Studies Aged Middle Aged *Delirium/etiology *Postoperative Complications/etiology Risk Factors *Hypnotics and Sedatives/adverse effects Water-Electrolyte Balance Pancreas/surgery |
| Natriuretic Peptides as a Predictor for Delirium After Cardiac Surgery: A Prospective Observational Study | Huisinga, C. Struck, E. Mihatsch, L. Heyn, J. Hagl, C. Zwissler, B. von Dossow, V. Saller, T. | J Clin Med | 2025 |
biomarker cardiac surgery delirium natriuretic peptides neurocognitive disorders quality of life short form 36 questionnaire |
| Albumin/fibrinogen ratio (AFR): a significant predictor of postoperative delirium in older patients undergoing non-neurosurgical and non-cardiac surgery | Huo, J. Song, Y. Lu, J. Dou, G. Chen, H. Mi, W. Yu, Y. Liu, Y. | BMC Geriatr | 2025 |
Humans Female Aged Male Retrospective Studies *Fibrinogen/analysis/metabolism *Postoperative Complications/diagnosis/epidemiology/blood *Delirium/diagnosis/blood/epidemiology Aged, 80 and over Prognosis Serum Albumin/metabolism Surgical Procedures, Operative/adverse effects Biomarkers/blood Predictive Value of Tests Risk Factors Aged patients Albumin to Fibrinogen Biomarker Postoperative delirium |
| Effect of Ascorbic Acid on the Incidence of Postoperative Delirium Among Elderly Patients Undergoing Cardiovascular Surgery: A Pilot Study | Iizuka, Y. Fukano, K. Oki, S. Sawada, I. Miyazawa, K. Ono, S. Yoshinaga, K. Sanui, M. Yamaguchi, A. | J Clin Med Res | 2025 |
Ascorbic acid Cardiac surgery Postoperative delirium |
| Preoperative Cognitive Optimization and Postoperative Cognitive Outcomes: A Narrative Review | Ishizawa, Y. | Clin Interv Aging | 2025 |
Humans *Delirium/prevention & control Aged Cognitive Dysfunction/prevention & control Postoperative Cognitive Complications/prevention & control Cognition Preoperative Care/methods Postoperative Complications/prevention & control cognitive frailty cognitive optimization perioperative neurocognitive disorder postoperative cognitive impairment postoperative delirium |
| Delirium risk profiles in a population-based study of United States older adults undergoing common noncardiac surgeries | Joo, H. Avelino-Silva, T. J. Diaz-Ramirez, L. G. Lee, S. J. Whitlock, E. L. | J Am Geriatr Soc | 2025 |
Humans Male Aged Female United States/epidemiology Risk Factors *Delirium/epidemiology Aged, 80 and over *Postoperative Complications/epidemiology Surgical Procedures, Operative/adverse effects Medicare/statistics & numerical data Risk Assessment/methods and noncardiac surgeries older adults postoperative delirium risk profile |
| Risk factors and outcomes of hyperactive delirium in older medical inpatients admitted to non-intensive care unit: a prospective cohort study | Kaewpongsa, P. Jayanama, K. Ruangritchankul, S. | BMC Psychiatry | 2025 |
Humans *Delirium/epidemiology/diagnosis Male Female Risk Factors Aged Prospective Studies Aged, 80 and over *Inpatients/statistics & numerical data Middle Aged Hospitalization *Psychomotor Agitation/epidemiology Hyperactive delirium Mortality Older adults Risk factor |
| A multicenter prospective study on the prevalence of Post Stroke Delirium and associated risk factors in Addis Ababa, Ethiopia | Ketema, B. Mengistu, G. Melka, D. Zenebe, Y. Zebenigus, M. Leul, F. | BMC Neurol | 2025 |
Humans *Delirium/epidemiology/etiology/diagnosis Ethiopia/epidemiology Female Male Risk Factors Prevalence Middle Aged Prospective Studies Aged *Stroke/epidemiology/complications Adult Aged, 80 and over Delirium Stroke Tikur Anbessa Specialized Hospital Yehulshet Specialty Center Yekatit 12 Hospital and Medical College |
| Clinical Profile and Outcome of Delirium in Patients in The Semi-Closed Intensive Care Unit | Keyal, N. K. Sherpa, A. D. Kumar, R. Ansari, I. | J Nepal Health Res Counc | 2025 |
Humans *Delirium/epidemiology Male *Intensive Care Units Female Prospective Studies Middle Aged Nepal/epidemiology Adult *apache Risk Factors Aged Length of Stay/statistics & numerical data Respiration, Artificial Delirium intensive care units mortality. |
| SURGE-ahead postoperative delirium prediction: external validation and open-source library | Kocar, T. D. Wolf, P. Leinert, C. Brefka, S. Fotteler, M. L. Uihlein, A. Wezel, F. Wehling, M. Rahbari, N. Kestler, H. Gebhard, F. Dallmeier, D. Denkinger, M. | Eur Geriatr Med | 2025 |
Artificial intelligence Delirium prediction Explainable AI Machine learning Postoperative delirium |
| The Impact of Non-Pharmacological Sleep Interventions on Delirium Prevention and Sleep Improvement in Postoperative ICU Patients: A Systematic Review and Network Meta-Analysis | Li, J. Fan, Y. Luo, R. Yin, N. Wang, Y. Jing, J. Zhang, J. | Intensive Crit Care Nurs | 2025 |
Humans *Delirium/prevention & control *Intensive Care Units/organization & administration *Network Meta-Analysis as Topic Delirium Intensive Care Unit Network meta-analysis Non-pharmacological interventions Sleep |
| Developing a nomogram for postoperative delirium in elderly patients with hip fractures | Li, L. Sheng, W. W. Song, L. J. Cheng, S. Cui, E. G. Zhang, Y. B. Yu, X. Z. Liu, Y. L. | World J Psychiatry | 2025 |
Hip fracture Nomogram Postoperative delirium Retrospective study Risk factor |
| The effect of perioperative cognitive training on postoperative delirium in older patients undergoing total hip and knee arthroplasty: a prospective randomised trial | Lia, T. Yua, C. Lv, F. Feng, Z. Hou, Y. Ren, L. Li, P. | Age Ageing | 2025 |
Humans Aged *Arthroplasty, Replacement, Knee/adverse effects *Arthroplasty, Replacement, Hip/adverse effects Male Female Prospective Studies Middle Aged Delirium/prevention & control/epidemiology/diagnosis/psychology/etiology Incidence Cognitive Behavioral Therapy/methods Postoperative Complications/prevention & control/epidemiology/etiology Cognition Treatment Outcome Perioperative Care/methods Cognitive Training general anaesthesia older people postoperative delirium total hip and knee arthroplasty |
| Delirium is a Potential Predictor of Unfavorable Long-term Functional Outcomes in Patients with Acute Ischemic Stroke: A Prospective Observational Study | Lin, C. Zhang, H. Xiao, F. Tu, Y. Lin, Y. Zhan, L. Lin, Y. Li, Y. Xie, C. Chen, Y. | J Inflamm Res | 2025 |
Ais Psd acute ischemic stroke biomarkers coagulation dysfunction delirium mRS modified rankin scale neuroinflammation post-stroke delirium |
| Evidence from a Mendelian randomization study: Delirium's noncausal role in dementia onset | Lu, Z. Wang, X. Mao, T. Liu, L. Zhang, J. | Neuroscience | 2025 |
Delirium Dementia Mendelian randomization Older people |
| Evaluation of postoperative delirium in cardiac surgery patients with the SDACS screening tool: a multicenter-multiphase study | Mahmoudi, H. Chalkias, A. Moradi, A. Moradian, S. T. Amouzegar, S. M. R. Vahedian-Azimi, A. | Perioper Med (Lond) | 2025 |
Cardiac surgery Critical care Delirium Early prediction Intensive care Screening tool |
| Nurse-perceived barriers and facilitators influencing optimal delirium care in acute care patients: Findings from the INVOLVE_RN study on barriers and facilitators | Mailhot, T. Crump, L. Clausen, C. Valentine-Joannette, T. Bouaouina, Z. Leblanc, M. E. Bitzas, V. Khetir, I. Lavoie, P. | Geriatr Nurs | 2025 |
Acute care Barriers Delirium Facilitators Guidelines Nursing practice |
| Delirium in the Acute Care Setting From the Families Perspective: A Scoping Review | McLean, A. Ewens, B. Towell-Barnard, A. | J Adv Nurs | 2025 |
acute care delirium families experience family centred care nursing |
| Establishment and validation of a nomogram of postoperative delirium in patients undergoing cardiac surgery: a retrospective study of MIMIC-IV | Mei, H. Liao, G. Ye, B. Wen, M. Li, J. | BMC Cardiovasc Disord | 2025 |
Humans *Nomograms Male Female Retrospective Studies *Cardiac Surgical Procedures/adverse effects Aged Middle Aged Risk Assessment Risk Factors *Predictive Value of Tests Reproducibility of Results *Decision Support Techniques Databases, Factual Delirium/diagnosis/etiology/epidemiology Treatment Outcome Cardiac surgery Icu Mimic-iv Nomogram Postoperative delirium |
| Cytokines and inflammatory biomarkers and their association with post-operative delirium: a meta-analysis and systematic review | Mosharaf, M. P. Alam, K. Gow, J. Mahumud, R. A. | Sci Rep | 2025 |
Humans *Biomarkers/blood *Cytokines/blood *Delirium/blood/etiology/diagnosis *Postoperative Complications/blood/etiology Inflammation/blood/metabolism C-reactive proteins Cytokines and inflammatory proteins Interleukins Post-operative delirium Systematic review and meta-analysis |
| Preoperative brain volume loss is associated with postoperative delirium in advanced heart failure patients supported by left ventricular assist device | Murrieta-Álvarez, I. Scioscia, J. P. Benítez-Salazar, J. M. Uwaeze, J. Xu, Z. Zheng, G. Li, S. Braverman, V. Walther, C. P. Shafii, A. E. Hochman-Mendez, C. Rosengart, T. K. Liao, K. K. Mondal, N. K. | Sci Rep | 2025 |
Humans *Heart-Assist Devices/adverse effects *Heart Failure *Delirium/etiology Male Female Middle Aged *Brain/diagnostic imaging/pathology Aged *Postoperative Complications/etiology Tomography, X-Ray Computed Atrophy Preoperative Period Retrospective Studies Brain Delirium Heart failure Mechanical circulatory support Neuroimaging Neurological dysfunction |
| Assessing delirium knowledge among health care professionals: findings from a scoping review | Muzzana, C. Mansutti, I. Palese, A. Ausserhofer, D. | BMC Nurs | 2025 |
Delirium Health personnel Healthcare professionals Instruments Knowledge Scoping review |
| Delirium assessment, management and barriers to effective care across Scotland: A secondary analysis of survey data from World Delirium Awareness Day 2023 | Naeem, F. Penfold, R. S. Soiza, R. L. Von Haken, R. Lindroth, H. Liu, K. Nydhal, P. Quinn, T. J. | J R Coll Physicians Edinb | 2025 |
*Delirium/therapy/diagnosis Humans Scotland Guideline Adherence/statistics & numerical data Surveys and Questionnaires Aged Prevalence Practice Guidelines as Topic Male Scotland/epidemiology delirium geriatrics hospitals |
| Screening of toxic-metabolic encephalopathy with and without epileptic seizure with density spectral array | Ohno, N. Neshige, S. Abe, T. Nonaka, M. Yamada, H. Takebayashi, Y. Ishibashi, H. Shishido, T. Aoki, S. Yamazaki, Y. Ueno, H. Iida, K. Maruyama, H. | J Neurol Sci | 2025 |
Loss of consciousness Neurotoxicity Nonconvulsive seizure Seizure Status epilepticus |
| Development and Validation of a Machine Learning Model for Early Prediction of Delirium in Intensive Care Units Using Continuous Physiological Data: Retrospective Study | Park, C. Han, C. Jang, S. K. Kim, H. Kim, S. Kang, B. H. Jung, K. Yoon, D. | J Med Internet Res | 2025 |
Humans *Delirium/diagnosis *Machine Learning *Intensive Care Units Male Retrospective Studies Female Middle Aged Aged Reproducibility of Results Adult delirium early prediction intensive care unit machine learning prediction model |
| Persistence of Delirium in Postacute Care at Skilled Nursing Facilities | Park, C. M. Shi, S. Jones, R. N. Metzger, E. D. Vasunilashorn, S. M. Fong, T. Kim, D. H. Inouye, S. K. | JAMA Netw Open | 2025 |
Humans *Skilled Nursing Facilities/statistics & numerical data *Delirium/epidemiology/diagnosis Female Male Cross-Sectional Studies *Subacute Care/statistics & numerical data Aged United States/epidemiology Aged, 80 and over *Medicare/statistics & numerical data |
| Delirium on presentation with a hip fracture is associated with adverse outcomes : a multicentre observational study of 18,040 patients using national clinical registry data | Penfold, R. S. Farrow, L. Hall, A. J. Clement, N. D. Ward, K. Donaldson, L. Johansen, A. Duckworth, A. D. Anand, A. Hall, D. E. Guthrie, B. MacLullich, A. M. J. | Bone Joint J | 2025 |
Humans *Delirium/epidemiology/etiology *Hip Fractures/complications/surgery Female Male *Registries Aged, 80 and over Aged Scotland/epidemiology Middle Aged Prevalence Hospital Mortality Risk Factors |
| Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis | Qiu, L. Q. Song, J. L. Zhang, L. C. Fan, B. Li, Q. Lu, B. Chen, G. Y. | Front Aging Neurosci | 2025 |
hypercholesterolemia hyperlipidemias hypertriglyceridemia meta-analysis postoperative delirium |
| Postoperative Delirium after Reverse Total Shoulder Arthroplasty: Interscalene Block Versus General Anesthesia | Rhee, S. M. Kim, S. Y. Kim, C. H. Radhakrishna, K. Dwivedi, D. D. Kim, S. Y. Ham, H. J. Rhee, Y. G. | Clin Orthop Surg | 2025 |
Humans Aged *Anesthesia, General *Arthroplasty, Replacement, Shoulder/adverse effects Aged, 80 and over Male Female Prospective Studies Case-Control Studies *Rotator Cuff Injuries/surgery Delirium/etiology Postoperative Complications/etiology Nerve Block Interscalene nerve block Postoperative delirium Total shoulder arthroplasty |
| Prevalence and Risk Factors for Delirium on Arrival at the Emergency Room by Ambulance | Sakuramoto, H. Onuma, J. Uno, S. Ikeda, M. Okamoto, S. Nakano, H. Hasimoto, H. Ouchi, A. | Cureus | 2025 |
ambulance delirium emergency room older adults psychiatry |
| Validation and Translation of the 3D-CAM to Turkish in Surgical Intensive Care Patients | Sarı, S. Dilsiz, P. Eker, T. Şahin, S. Şahin, M. D. Doğan, B. Özçiftçi, P. Özcan, H. Dostbil, A. İyisoy, M. S. Turan, O. Taşkın, F. Kyenshilik, D. Kazaylek, M. İnce, İ Turan, A. | Turk J Anaesthesiol Reanim | 2025 |
3d-cam Delirium Intensive Care Turkish Version Validation |
| Evaluating oxygen reserve index-guided oxygenation for the prevention of postoperative delirium in elderly patients: a randomized controlled trial | Sarıtaş, P. U. Sarıtaş, A. Poyraz, MÇ | Croat Med J | 2025 |
Humans Aged Female Male *Oximetry *Postoperative Complications/prevention & control Delirium/prevention & control/etiology Aged, 80 and over Oxygen/blood Incidence Oxygen Inhalation Therapy/methods Oxygen Saturation |
| Delirium prevalence and management in general wards, emergency departments, rehabilitation centres and nursing homes in Germany, Austria and Switzerland (DACH countries): A secondary analysis of a worldwide point prevalence study | Schimböck, F. Krüger, L. Hoffmann, M. Jeitziner, M. M. Lindroth, H. Liu, K. Nydahl, P. Von Haken, R. Thomas Exl, M. Fischbacher, S. | Int J Nurs Stud Adv | 2025 |
Delirium Encephalopathy Nurses Prevalence Protocol |
| Lipid Dysregulation and Delirium in Older Adults: A Review of the Current Evidence and Future Directions | Shaw, A. Teng, R. Fasina, T. Gonzales, A. S. Wong, A. Schweitzer, D. Akefe, I. | Brain Res Bull | 2025 |
Delirium Endocannabinoids Fatty Acids Healthy Ageing Lipid Dysregulation Neuropsychiatric Disorders Phospholipids Sphingolipids |
| Risk factors for transitions and outcomes of subsyndromal delirium in the ICU: Post-hoc analysis of a prospective multicenter cohort study | Smit, L. Wiegers, E. J. A. Trogrlic, Z. Gommers, D. Ista, E. van der Jagt, M. | J Crit Care | 2025 |
Critical care Delirium Diagnosis Intensive care unit Outcomes Risk factors |
| Protein Alterations in Patients with Delirium after Cardiac Surgery: An Exploratory Case-Control Substudy of the VISION Cardiac Surgery Biobank | Spence, J. Devereaux, P. J. Bashir, S. Brady, K. Sun, T. Chan, M. T. V. Wang, C. Y. Lamy, A. Whitlock, R. P. McIntyre, W. F. Belley-Côté, E. Paré, G. Chong, M. | Anesthesiology | 2025 |
Humans Male Female *Cardiac Surgical Procedures/adverse effects Case-Control Studies *Delirium/blood/etiology/diagnosis Aged *Biomarkers/blood *Postoperative Complications/blood/diagnosis/etiology *Biological Specimen Banks Middle Aged Blood Proteins/analysis Cohort Studies |
| Association Between Oxidative Stress Markers and Postoperative Delirium in Elderly Patients Undergoing Oncologic Surgery | Stanculescu, A. D. Dragoescu, P. O. Andrei, M. Chiutu, L. Dragoescu, N. A. | Curr Health Sci J | 2024 |
Postoperative delirium glutathione peroxidase malondialdehyde superoxide dismutase |
| Long-term mortality impact of postoperative hyperactive delirium in older hip fracture surgery patients | Sun, M. Chen, W. M. Wu, S. Y. Zhang, J. | BMC Geriatr | 2025 |
Humans Female *Hip Fractures/surgery/mortality Male Aged Aged, 80 and over *Postoperative Complications/mortality/epidemiology/diagnosis *Delirium/mortality/epidemiology/diagnosis Taiwan/epidemiology Risk Factors Cohort Studies Propensity Score Hip fracture Mortality Older Postoperative hyperactive delirium Propensity score matching |
| Person-centered care-based digital transformation education program for elderly dementia patients with delirium: a comparison of the effect on nurses and doctors | Suzuki, M. Ito, T. Inagaki, K. Mimuro, S. Yamakawa, M. Takiue, K. Sawaki, K. Komatsu, Y. Uchiyama, M. Kawashima, C. Yamazaki, K. Satoh, M. Isogai, S. | Nihon Ronen Igakkai Zasshi | 2025 |
Humans *Dementia/nursing/therapy *Patient-Centered Care *Delirium/therapy/nursing Aged *Nurses Female *Physicians Male Surveys and Questionnaires Delirium Dementia Digital transformation (DX) program Person-centered care |
| Risk factors for postoperative delirium in patients undergoing orthopedic procedures: a systematic review and meta-analysis | Suzuki, R. Nakanishi, A. Masuya, M. Fukuroku, K. Taneda, Y. Matsuura, Y. | PLoS One | 2025 |
Humans Risk Factors *Orthopedic Procedures/adverse effects *Delirium/etiology/epidemiology *Postoperative Complications/etiology/epidemiology Length of Stay |
| Airway Safety During Mechanical Ventilation: Survey of ICU Clinicians Practices and Perceptions | Tanios, M. A. Stocking, J. C. Charchaflieh, J. G. Miller, A. G. Patel, J. V. Vilella, A. L. Nguyen, H. M. Epstein, S. K. Beltran, A. Devlin, J. W. | Crit Care Explor | 2025 |
Humans *Intensive Care Units *Respiration, Artificial/adverse effects Surveys and Questionnaires Airway Management/methods/adverse effects Patient Safety Airway Extubation/adverse effects Attitude of Health Personnel Practice Patterns, Physicians’/statistics & numerical data |
| A Cross-Sectional Study of Online Survey Respondents' Knowledge and Attitudes Toward Delirium | Townshend, R. Vasilevskis, E. E. Hollnagel, F. Golden, B. P. | J Gen Intern Med | 2025 |
caregiver education delirium patient education |
| Impact of Ketamine and Propofol on Cognitive Function in Elderly Patients: A Systematic Review | Van de Vel, G. Mun, S. Zia, S. U. D. Chalasani, R. Shukla, P. S. Malasevskaia, I. | Cureus | 2025 |
delirium elderly ketamine postoperative cognitive dysfunction propofol |
| Preoperative quantitative quadriceps muscle ultrasound to predict POD for gastrointestinal surgery in older patients | Wang, C. Song, X. Cao, L. Guo, F. Gao, J. | BMC Gastroenterol | 2025 |
Humans Male Female Aged *Ultrasonography/methods *Quadriceps Muscle/diagnostic imaging *Postoperative Complications/etiology/diagnostic imaging *Digestive System Surgical Procedures/adverse effects/methods Risk Factors Prospective Studies *Delirium/etiology Preoperative Period Aged, 80 and over Nomograms ROC Curve China Logistic Models Predictive Value of Tests Gastrointestinal surgery Nomogram Postoperative delirium Quantitative muscle ultrasound |
| Medical staff's knowledge of delirium by occupation and the effectiveness of an on-demand e-learning | Yamagata, H. Kobayashi, R. Hirose, K. Seki, T. Takihara, T. | PCN Rep | 2025 |
delirium e‐learning liaison psychiatry staff education team‐based medicine |
| The relationship between preoperative serum indirect bilirubin and postoperative delirium in geriatric patients undergoing joint replacement | Yu, R. Yang, M. Chen, J. Zhang, F. | PLoS One | 2025 |
Humans Male Female Aged *Bilirubin/blood Aged, 80 and over *Arthroplasty, Replacement, Knee/adverse effects *Delirium/blood/etiology/diagnosis *Postoperative Complications/blood/etiology Arthroplasty, Replacement, Hip/adverse effects Risk Factors Preoperative Period |
| Exploring the causal relationship between delirium and sarcopenia using bidirectional two-sample Mendelian randomization study | Zhou, R. Fu, Y. Wan, P. Cheng, B. | Prog Neuropsychopharmacol Biol Psychiatry | 2025 |
Appendicular lean mass Delirium Gwas Low hand-grip strength Mendelian randomization |
| Preventive effects of early mobilisation on delirium incidence in critically ill patients: systematic review and meta-analysis | Zhou, L. Xie, F. Zeng, Y. Xia, X. Wang, R. Cai, Y. Lei, Y. Xu, F. Li, X. Chen, B. | Med Klin Intensivmed Notfmed | 2025 |
Delirium Early mobilisation Intervention Non-drug intervention Rehabilitation |
| Comparison of the effects of perioperative fentanyl and morphine use on the short-term prognosis of patients with cardiac surgery in the ICU | Zhong, J. Sui, R. Zi, J. Wang, A. | Front Pharmacol | 2024 |
cardiac surgery delirium fentanyl in-hospital mortality morphine |
| Comparison of the effects of perioperative fentanyl and morphine use on the short-term prognosis of patients with cardiac surgery in the ICU | Zhong, J. Sui, R. Zi, J. Wang, A. | Front Pharmacol | 2024 |
cardiac surgery delirium fentanyl in-hospital mortality morphine |
| Comparison of the effects of perioperative fentanyl and morphine use on the short-term prognosis of patients with cardiac surgery in the ICU | Zhong, J. Sui, R. Zi, J. Wang, A. | Front Pharmacol | 2024 |
cardiac surgery delirium fentanyl in-hospital mortality morphine |
| Development and usability evaluation of a nurse-led clinical decision support system (AI-AntiDelirium) for management of intensive care unit delirium: A mixed methods study | Zhang, S. Ding, S. Cui, W. Li, X. Wei, J. Wu, Y. | Appl Nurs Res | 2025 |
Humans *Delirium/nursing Cross-Sectional Studies *Decision Support Systems, Clinical Female Male Adult *Intensive Care Units Middle Aged Critical Care Nursing/methods/standards Nursing Staff, Hospital/psychology Clinical decision supporting system Delirium Intensive care unit Nurses Usability testing |
| Serum-derived exosomal microRNAs as biomarkers for postoperative delirium | Xu, M. Chen, Y. Lin, Y. Wang, D. Zheng, X. | Front Neurosci | 2025 |
biomarkers cognitive decline microRNA postoperative delirium serum exosomes |
| Enhanced machine learning predictive modeling for delirium in elderly ICU patients with COPD and respiratory failure: A retrospective study based on MIMIC-IV | Wu, Z. B. Jiang, Y. L. Li, S. S. Li, A. | PLoS One | 2025 |
Humans *Delirium/diagnosis *Machine Learning Aged Female Male *Pulmonary Disease, Chronic Obstructive/complications *Intensive Care Units *Respiratory Insufficiency Retrospective Studies Aged, 80 and over Risk Factors Prognosis |
| Unraveling the impact of frailty on postoperative delirium in elderly surgical patients: a systematic review and meta-analysis | Wu, H. Yan, S. Cao, H. Feng, C. Zhang, H. | BMC Anesthesiol | 2025 |
Humans *Frailty Aged Postoperative Complications/epidemiology Frail Elderly Delirium/epidemiology Emergence Delirium/epidemiology Delirium Elderly Frailty Meta-analysis |
| Evaluating the relationship between inflammatory markers and preoperative delirium in elderly hip fracture patients: A retrospective observational study | Wang, S. Yu, S. Li, C. Li, T. Li, H. Zhang, B. Han, L. Zhan, H. Zhang, Y. | Medicine (Baltimore) | 2025 |
Humans *Hip Fractures/surgery/blood/complications *Delirium/blood/etiology/diagnosis/epidemiology Male Retrospective Studies Female Aged Aged, 80 and over *Biomarkers/blood Inflammation/blood Preoperative Period Risk Factors Age Factors Neutrophils/metabolism Comorbidity |
| Predictors of postoperative delirium in patients undergoing radical prostatectomy: a prospective study | Wang, H. Chen, J. Chen, J. Chen, Y. Qin, Y. Liu, T. Pan, S. Xie, Y. | Support Care Cancer | 2025 |
Humans Male Prospective Studies *Prostatectomy/adverse effects/methods Aged Risk Factors *Postoperative Complications/epidemiology/etiology *Delirium/etiology/epidemiology Middle Aged *Nomograms Prostatic Neoplasms/surgery Logistic Models Elderly patients Nomogram Postoperative delirium Prostate cancer |
| Development of a Disease Model for Predicting Postoperative Delirium Using Combined Blood Biomarkers | Wan, H. Tian, H. Wu, C. Zhao, Y. Zhang, D. Zheng, Y. Li, Y. Duan, X. | Ann Clin Transl Neurol | 2025 |
blood biomarkers cognitive decline hyperlipidemia machine learning postoperative delirium |
| Consequences of the Crisis in Social Care for Older Hospital Inpatients with Frailty | Ahmed, R. Cloonan, J. May, E. Chambers, H. Madden, R. Doyle, J. Briggs, R. | Ir Med J | 2025 |
Humans Female Male Aged Aged, 80 and over *Frail Elderly *Quality of Life Patient Discharge Inpatients/psychology Home Care Services Depression/epidemiology Frailty Accidental Falls/statistics & numerical data/prevention & control Delirium/therapy/epidemiology Loneliness/psychology Hospitalization/statistics & numerical data |
| Predicting Postoperative Delirium Using Intraoperative Neuromonitoring in Patients Undergoing Craniotomy for Aneurysm Clipping Surgery | Al-Qudah, A. M. Alkalbani, L. Tallapaneni, P. S. Vinuthna, D. V. Suresh, V. Anetakis, K. M. Crammond, D. Balzer, J. Shandal, V. Visweswaran, S. Subramaniam, K. Sadhasivam, S. Thirumala, P. | Eur Neurol | 2025 |
Postoperative delirium, Intracranial surgery, IONM, SSEPs, EEG, CBF |
| Intraoperative neuromonitoring as an independent predictor for postoperative delirium in ICU following aneurysm clipping | Al-Qudah, A. M. Tallapaneni, P. S. Crammond, D. J. Balzer, J. Anetakis, K. M. Shandal, V. Biaesch, J. Ghannam, M. Nadkarni, N. Gross, B. A. Lang, M. Subramanium, K. Sadhasivam, S. Thirumala, P. D. | eNeurologicalSci | 2025 |
Aneurysm Clipping Craniotomy Delirium Icu Intraoperative neurophysiologic monitoring SSEP EEG |
| Daylighting and Patients' Access to View Assessment in the Palestinian Hospitals' ICUs | Amleh, D. Halawani, A. Haj Hussein, M. Alamlih, L. | Herd | 2025 |
Icu access to view daylight delirium human health |
| Virtual Reality Simulation to Improve Postoperative Cardiothoracic Surgical Patient Outcomes | Anderson, R. J. Bauer, P. R. Arghami, A. Haney, R. M. Reisdorf, E. M. Baalson, K. | Am J Crit Care | 2025 |
Humans *Virtual Reality Male Female Middle Aged Aged *Intensive Care Units Cardiac Surgical Procedures Postoperative Complications/prevention & control Respiration, Artificial |
| Association of Number of Oral bacteria with Ventilator-Associated Pneumonia and Delirium in Patients in the Intensive Care Unit | Arimizu, C. Akahoshi, T. Jinno, T. Furuta, M. Ohashi, A. Takamori, S. Wada, N. | J Intensive Care Med | 2025 |
delirium intensive care unit oral bacterial count oral care ventilator-associated pneumonia |
| Impact of a Collaborative Pharmacist-Cardiovascular Surgeon Protocol for High Risk of Postoperative Delirium on Benzodiazepine Prescription Trends in Hospitalized Patients | Asai, Y. Nakano, Y. Yanagawa, T. Takahashi, M. Iwamoto, T. | Biol Pharm Bull | 2025 |
Humans *Benzodiazepines/therapeutic use/adverse effects Retrospective Studies *Pharmacists *Delirium/drug therapy/epidemiology/prevention & control Male Female Aged *Postoperative Complications/prevention & control/epidemiology Middle Aged Surgeons Drug Prescriptions/statistics & numerical data Practice Patterns, Physicians’/trends/statistics & numerical data Cardiovascular Surgical Procedures/adverse effects Hospitalization/trends Aged, 80 and over Interrupted Time Series Analysis benzodiazepine insomnia drug interrupted time series prescription trend protocol-based pharmacotherapy management |
| Supportive Interventions Involving Family Carers of Patients With Delirium Superimposed on Dementia in Hospital: A Scoping Review | Ashton-Gough, C. Lynch, J. Goodman, C. | Int J Older People Nurs | 2025 |
Humans *Delirium/nursing *Dementia/nursing/complications *Caregivers/psychology Hospitalization Aged Family/psychology carers delirium dementia family caregiving non‐pharmacological interventions |
| The Misdiagnosis and Underdiagnosis of Hepatic Encephalopathy | Bloom, P. P. | Clin Transl Gastroenterol | 2025 |
*Hepatic Encephalopathy/diagnosis/etiology Humans *Diagnostic Errors *Liver Cirrhosis/complications/diagnosis *Cognitive Dysfunction/diagnosis/etiology Diagnosis, Differential Delirium/diagnosis/etiology Dementia/diagnosis Risk Factors |
| Delirium in Neurocritical Care: Uncovering Undisclosed Psychotropic Substance and Medication Use and Stress Exposure by Hair Analysis | Bögli, S. Y. Capone, C. Baumgartner, M. R. Quednow, B. B. Kraemer, T. Keller, E. Binz, T. M. | Neurocrit Care | 2025 |
Humans Male Female Middle Aged Aged *Delirium/metabolism/etiology/drug therapy *Psychotropic Drugs Adult *Critical Care *Hair Analysis Stress, Psychological/metabolism Hair/chemistry/metabolism Endocannabinoids/metabolism Brain Injuries/metabolism/complications Acute brain injury Delirium Hair analysis Neurocritical care |
| Sublingual sufentanil after orthopaedic and abdominal surgery: long-term outcome and safety | Borck, M. Wandrey, J. D. Spies, C. Tafelski, S. | Perioper Med (Lond) | 2025 |
Patient-controlled analgesia Postoperative chronic pain Postoperative delirium Postoperative pain management Sublingual sufentanil tablet system |
| A single-center prospective cohort study assessing preoperative gait speed assessment as a prognostic tool for morbidity and mortality in frail elderly patients undergoing abdominal surgery | Cai, P. P. Gu, L. L. Wang, X. Wu, C. L. Ye, X. H. Zhang, K. Z. | Braz J Med Biol Res | 2025 |
Humans Prospective Studies Aged Female Male *Frail Elderly *Walking Speed/physiology *Postoperative Complications/mortality Prognosis Aged, 80 and over Risk Factors *Geriatric Assessment/methods Abdomen/surgery Risk Assessment/methods Predictive Value of Tests Preoperative Period |