What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Detecting and managing cognitive impairment in cardiac patients: insights from qualitative interviews with nurses | Zhao, E. Bloomfield, J. Lowres, N. Gallagher, R. | Contemp Nurse | 2024 |
barriers |
| The Management and Prevention of Delirium in Elderly Patients Hospitalised in Intensive Care Units: A Systematic Review | Zaher-Sánchez, S. Satústegui-Dordá, P. J. Ramón-Arbués, E. Santos-Sánchez, J. A. Aguilón-Leiva, J. J. Pérez-Calahorra, S. Juárez-Vela, R. Sufrate-Sorzano, T. Angulo-Nalda, B. Garrote-Cámara, M. E. Santolalla-Arnedo, I. Echániz-Serrano, E. | Nurs Rep | 2024 |
Icu |
| Pharmacological Prevention of Postoperative Delirium in Adults: A Review of Recent Literature | White, N. C. Cowart, C. R. Cios, T. J. | Curr Neurol Neurosci Rep | 2024 |
Anesthesia |
| DELirium treatment with Transcranial Electrical Stimulation (DELTES): study protocol for a multicentre, randomised, double-blind, sham-controlled trial | van der, A. J. Lodema, Y. Ottens, T. H. Schutter, Djlg Emmelot-Vonk, M. H. de Haan, W. van Dellen, E. Tendolkar, I. Slooter, A. J. C. | BMJ Open | 2024 |
Humans |
| Delirium risk and mortality in people with pre-existing severe mental illness: a retrospective cohort study using linked datasets in England | Bauernfreund, Y. Launders, N. Favarato, G. Hayes, J. F. Osborn, D. Sampson, E. L. | Psychol Med | 2024 |
Schizophrenia |
| Factors Affecting Delirium Care Core Competency Among Nurses: A Descriptive Correlational Study | Bae, K. S. Roh, Y. S. | Nurs Health Sci | 2024 |
Humans |
| Understanding Barriers to Early Rehabilitation Following the Surgery for Fragility Hip Fractures: A Single-Centre Audit | Al-Dahan, T. Murhekar, S. Abed, M. Shinde, K. | Cureus | 2024 |
delerium |
| The Association of Selective Serotonin Reuptake Inhibitors with Delirium in Post-Operative Adults: A Secondary Analysis of a Post-Operative Dataset with Daily Severity of Illness Adjustment | Austin, C. A. Bazemore, I. Yi, J. Glier, S. Carson, S. S. | Delirium Commun | 2024 |
Delirium |
| Evaluation of the effects of a team-based systematic prevention and management program for postoperative orthopedic older patients: A retrospective cohort study | Yamaguchi, F. Inomata, C. Yoshinaga, N. Sawada, H. Shimamoto, K. Haruta-Tsukamoto, A. | PCN Rep | 2024 |
delirium |
| Incidence of Delirium in ICU Patients With and Without COVID-19 in a Costa Rican Hospital | Zavaleta-Monestel, E. Martínez-Vargas, E. Chaverri-Fernández, J. Díaz-Madriz, J. P. Fallas-Mora, A. Alvarado-Ajun, P. Rojas-Chinchilla, C. García-Montero, J. | Cureus | 2024 |
covid-19 |
| The associations of post-stroke delirium with outcomes: a systematic review and meta-analysis | Zhang, G. B. Lv, J. M. Yu, W. J. Li, H. Y. Wu, L. Zhang, S. L. Shi, G. Z. Huang, H. W. | BMC Med | 2024 |
Humans |
| Preoperative frailty tendency predicts delirium occurrence in older people undergoing spinal surgery | Zhang, Y. Zhang, X. Qi, P. Lu, J. Yang, M. | BMC Geriatr | 2024 |
Humans |
| Systemic immune inflammatory index (SII) and systemic inflammatory response index (SIRI) as predictors of postoperative delirium in patients undergoing off-pump coronary artery bypass grafting (OPCABG) with cerebral infarction | Zhao, B. S. Zhai, W. Q. Ren, M. Zhang, Z. Han, J. G. | BMC Surg | 2024 |
Humans |
| How to predict postoperative delirium in geriatric patients with hip fracture as soon as possible? A retrospective study | Zhao, S. Sun, T. Zhang, J. Wang, Y. Guo, Y. Wang, X. | BMC Surg | 2024 |
Humans |
| Clinical investigation into risk factors for delirium post-cardiac surgery and its implications for nursing intervention guided by behavior change theory | Zhao, Y. Guo, S. Wang, Z. Dong, Y. Wei, W. Su, Z. | J Cardiothorac Surg | 2024 |
Humans |
| Incidence and risk factors of postoperative delirium in lumbar spinal fusion patients: A National Database analysis | Zheng, Y. Wang, J. Liu, Z. Wang, J. Yang, Q. Ren, H. Feng, L. | World Neurosurg | 2024 |
Lumbar fusion |
| Translation, cultural debugging, and validation of the Chinese version of the Sour Seven Questionnaire: a cross-sectional study | Zhu, S. Liu, S. Li, L. Xing, H. Xia, M. Dong, G. | Front Med (Lausanne) | 2024 |
Chinese version |
| Psychiatric Etiologies and Approaches in Altered Mental Status Presentations: Insights from Consultation Liaison Psychiatry | Hamm, B. Rosenthal, L. J. | Semin Neurol | 2024 |
Altered mental status Psychiatry Delirium
|
| Bispectral Index Monitoring Effect on Delirium Occurrence and Nursing Quality Improvement in Post-anesthesia Care Unit Patients Recovering From General Anesthesia: A Randomized Controlled Trial | Huang, Y. Huang, L. Xu, J. Bao, Y. Qu, Y. Huang, Y. | Cureus | 2024 |
bispectral index |
| Impact of Frailty and Delirium Among Older Adults Admitted With Acute Decompensated Heart Failure | Irizarry-Caro, J. A. Kumar, M. Wang, Q. Rohant, N. Goyal, P. Damluji, A. A. Kirkpatrick, J. N. Kwak, M. J. | JACC Adv | 2024 |
acute decompensated heart failure |
| Improving hospice delirium guideline adoption through an understanding of barriers and facilitators: A mixed-methods study | Jackson, C. Malia, C. Zacharias, H. Dyson, J. Johnson, M. J. | PLoS One | 2024 |
Humans |
| Machine learning-based delirium prediction in surgical in-patients: a prospective validation study | Jauk, S. Kramer, D. Sumerauer, S. Veeranki, S. P. K. Schrempf, M. Puchwein, P. | JAMIA Open | 2024 |
clinical decision support
delirium
electronic health records
prediction algorithms
random forest
|
| Risk factors for postoperative delirium in patients with cardiac surgery | Kim, M. S. Kim, S. H. | Sci Prog | 2024 |
Humans |
| Delirium in the ICU: how much do we know? A narrative review | Liu, S. B. Wu, H. Y. Duan, M. L. Yang, R. L. Ji, C. H. Liu, J. J. Zhao, H. | Ann Med | 2024 |
*Delirium/diagnostic imaging/pathology/therapy |
| The role of C-reactive protein as a risk marker of postoperative delirium in older hip fracture patients: a prospective cohort study | Lozano-Vicario, L. Muñoz-Vázquez Á, J. Cedeno-Veloz, B. A. Romero-Ortuno, R. Galbete, A. Fernández-Irigoyen, J. Santamaría, E. Zambom-Ferraresi, F. Ortiz-Gómez, J. R. Hidalgo-Ovejero Á, M. Martínez-Velilla, N. | Eur Geriatr Med | 2024 |
C-reactive protein |
| Low-dose clonidine infusion to improve sleep in postoperative patients in the high-dependency unit. A randomised placebo-controlled single-centre trial | Liu, D. Hallt, E. Platz, A. Humblet, A. Lassig-Smith, M. Stuart, J. Fourie, C. Livermore, A. McConnochie, B. Y. Starr, T. Herbst, K. Woods, C. A. Pincus, J. M. Reade, M. C. | Intensive Care Med | 2024 |
Clonidine |
| A nomogram for predicting the risk of postoperative delirium in individuals undergoing cardiovascular surgery | Liu, C. Zhang, L. Tang, W. Zhao, S. Li, M. Li, J. Shao, Y. | Eur J Neurol | 2024 |
cardiovascular surgery |
| Comparative Diagnostic Accuracy of Nursing Delirium Screening Scale Versus Confusion Assessment Method for Postoperative Delirium: A Systematic Review and Meta-Analysis | Lin, C. J. Fick, D. M. Traynor, V. Chen, Y. C. Hsiang, H. F. Chiu, H. Y. | J Clin Nurs | 2024 |
Confusion Assessment Method |
| The clinical value of nonpharmacological interventions for preventing postoperative delirium: a narrative review | Li, T. Feng, Z. Hou, Y. Li, P. | Minerva Anestesiol | 2024 |
Humans |
| N-methyl-d-aspartate (NMDA) receptor antagonists for treatment of catatonia in adults: Narrative review | Lee, J. H. Suzuki, J. | Gen Hosp Psychiatry | 2024 |
Amantadine |
| Postoperative Delirium Following Posterior Lumbar Spinal Fusion: Epidemiology, Risk Factors, and Associated Complications | Knebel, A. Singh, M. Rasquinha, R. Daher, M. Nassar, J. E. Hanna, J. Diebo, B. G. Daniels, A. H. | World Neurosurg | 2024 |
Complications |
| Co-designing a digital family-led intervention for delirium prevention and management in adult critically ill patients: An application of the double diamond design process | Johnson, G. U. Towell-Barnard, A. McLean, C. Robert, G. Ewens, B. | Int J Nurs Stud | 2024 |
Co-design |
| Reduction of Rehospitalization With Addition of Geriatrics/Transitions of Care Consult Service | Jackson, A. E. Brubaker, A. N. Coffey, C. R. Kalender-Rich, J. L. | J Am Med Dir Assoc | 2024 |
Long-term care |
| Postoperative neurocognitive disorders in ambulatory surgery: a narrative review | In, J. Chen, B. Bae, H. Kinjo, S. | Korean J Anesthesiol | 2024 |
Humans |
| Preoperative assessment of hyperactive delirium risk after head and neck surgery with free tissue transfer reconstruction | Imai, T. Takasago, T. Nakanome, A. Morita, S. Miyakura, Y. Sasaki, K. Ito, K. Goto, T. Asada, Y. | Auris Nasus Larynx | 2024 |
Head and neck neoplasms |
| Long-Term Impact of Delirium on the Risk of Dementia in Hospitalized Older Patients: A Real-World Multicenter Study | Hwang, G. Park, C. Son, S. J. Roh, H. W. Hwang, J. Y. Jang, J. W. Jo, Y. T. Byeon, G. Youn, H. Park, R. W. | Am J Geriatr Psychiatry | 2024 |
Alzheimer’s disease |
| Comprehensive signal detection of delirium-associated medication using the Food and Drug Administration Adverse Event Reporting System | Hatano, M. Sogawa, R. Shin, K. Esumi, S. Ishikawa, A. Mizumura, R. Araki, H. Yamada, S. | Gen Hosp Psychiatry | 2024 |
Humans |
| Inhibited hypoxia-inducible factor by intraoperative hyperglycemia increased postoperative delirium of aged patients: A review | Han, Y. Ji, B. Leng, Y. Xie, C. | Medicine (Baltimore) | 2024 |
Humans |
| Development and Validation of Machine Learning Models to Predict Postoperative Delirium Using Clinical Features and Polysomnography Variables | Ha, W. S. Choi, B. K. Yeom, J. Song, S. Cho, S. Chu, M. K. Kim, W. J. Heo, K. Kim, K. M. | J Clin Med | 2024 |
machine learning |
| Association between baseline serum bicarbonate and the risk of postoperative delirium in patients undergoing cardiac surgery in the ICU: a retrospective study from the MIMIC-IV database | Guo, P. Ma, Y. Su, W. Xie, D. Li, X. Wang, K. Wang, P. | BMC Anesthesiol | 2024 |
Humans |
| Non-pharmacological delirium detection and management interventions for informal caregivers of older people at home: A scoping review protocol | Fox, M. T. Maimets, I. K. Butler, J. I. Sidani, S. Godfrey, C. | PLoS One | 2024 |
Humans |
| Delirium in nursing home residents: is there a role of antidepressants? A cross sectional study | Fedecostante, M. Balietti, P. Di Santo, S. G. Zambon, A. Marengoni, A. Morandi, A. Beccacece, A. Bellelli, G. Cherubini, A. | BMC Geriatr | 2024 |
Humans |
| The use of peripheral nerve block decrease incidence of postoperative cognitive dysfunction following orthopedic surgery: A systematic review and meta-analysis | Deng, L. Jiao, B. Cai, J. Xu, X. Chen, M. Yan, C. Zhu, T. Liu, J. Ma, D. Chen, C. | BMC Anesthesiol | 2024 |
Humans |
| Optimizing anesthesia management based on early identification of electroencephalogram burst suppression risk in non-cardiac surgery patients: a visualized dynamic nomogram | Chen, J. Li, W. Chen, Q. Zhou, Z. Chen, C. Hu, Y. Si, Y. Zou, J. | Ann Med | 2024 |
Humans |
| Routine cognitive screening for older people undergoing major elective surgery: Benefits, risks and costs | Chan, L. K. Chuan, A. Berney, C. R. Chan, D. K. | Anaesth Intensive Care | 2024 |
Humans |
| Prevalence and risk factors of subsyndromal delirium in ICU: A systematic review and meta-analysis | Ma, X. Cheng, H. Zhao, Y. Zhu, Y. | Intensive Crit Care Nurs | 2024 |
Intensive care unit |
| Predisposing and precipitating factors for the development of postoperative delirium in critically ill patients in a university intensive care unit | Marques, D. M. Alves, Ddsb Vernaglia, T. V. C. | Rev Lat Am Enfermagem | 2024 |
Humans |
| Diagnostic test accuracy of screening tools for the detection of neurocognitive disorders in older adults post-trauma: A protocol for a systematic review | Merriman, N. A. Walsh, M. E. O'Regan, N. Carrigan, M. Hickey, P. Brent, L. Blake, C. | HRB Open Res | 2024 |
cognition |
| How much risk does delirium represent for the development of dementia?: Retrospective cohort study from over 260,000 patients record in a solitary institution | Minami, H. Toyoda, K. Hata, T. Nishihara, M. Neo, M. Nishida, K. Kanazawa, T. | Front Psychiatry | 2024 |
cognitive decline |
| Effectiveness of the ABCDEF Bundle to Manage and Prevent Delirium: Pre- and Postintervention Quasi-Experimental Study | Nagy Nagm Eldean, T. Hassan Bakri, M. Anwar Abdel Aziz, M. Shalaby Khalaf, G. | Crit Care Nurs Q | 2024 |
Humans |
| C reactive protein albumin ratio as a new predictor of postoperative delirium after cholecystectomy for acute cholecystitis | Nakatake, R. Funatsuki, T. Koshikawa, Y. Okuyama, T. Ishizaki, M. Takekita, Y. Kato, M. Kitade, H. | Sci Rep | 2024 |
Humans |
| The impact of preoperative psychiatric intervention for postoperative delirium after major oral and maxillofacial surgery with free flap reconstruction | Nitta, Y. Sanuki, T. Sugino, S. Sugimoto, M. Kido, K. | J Stomatol Oral Maxillofac Surg | 2024 |
Free flap reconstruction |
| Impact of beta-blocker usage on delirium in patients with sepsis in ICU: a cross-sectional study | Ouyang, H. Wang, X. Deng, D. Wang, Q. Yu, Y. | Front Med (Lausanne) | 2024 |
ICU stay |
| Utilization of NIRS Monitor to Compare the Regional Cerebral Oxygen Saturation Between Dexmedetomidine and Propofol Sedation in Mechanically Ventilated Critically ill Patients with Sepsis- A Prospective Randomized Control Trial | Patidar, A. K. Khanna, P. Kashyap, L. Ray, B. R. Maitra, S. | J Intensive Care Med | 2024 |
delirium |
| Postoperative Delirium and Neurocognitive Disorders: A Comprehensive Review of Pathophysiology, Risk Factors, and Management Strategies | Paunikar, S. Chakole, V. | Cureus | 2024 |
cognitive impairment |
| Preoperative serum ferritin as a biomarker for predicting delirium among elderly patients receiving non-cardiac surgery: a retrospective cohort study | Ruan, X. Li, Y. Yuan, M. Li, H. Lou, J. Liu, Y. Cao, J. Ma, Y. Mi, W. Zhang, X. | Transl Psychiatry | 2024 |
Humans |
| Circadian disturbances, anxiety and motor disturbances differentiate delirium superimposed on dementia from dementia-only | Schnorr, T. Fleiner, T. Trumpf, R. Prüter-Schwarte, C. Fanselow, J. Zijlstra, W. Haussermann, P. | Front Psychiatry | 2024 |
acute hospital |
| Real-World Adherence to a Delirium Screening Test Administered by Nurses and Medical Staff during Routine Patient Care | Soboh, R. Rotfeld, M. Gino-Moor, S. Jiries, N. Ginsberg, S. Oliven, R. | Brain Sci | 2024 |
Radar |
| Dexmedetomidine for Postoperative Delirium Prevention in the Older Adult: An Integrative Review | Strada, A. L. Tevay, A. Scoggins, M. Gonzalez, K. | Aana j | 2024 |
Humans |
| Improving delirium assessments in acute senior health: A quality improvement project for care of the older person | Taylor, C. Peakman, G. Mackinnon, L. Mohamadzade, N. Han, W. Mackie, L. Gandhi, J. Mitchell, O. Bateman-Champain, C. Hetherington, J. Belarbi, F. Alg, G. | BMC Geriatr | 2024 |
Alzheimer’s disease |
| Postoperative delirium among elderly elective orthopedic patients in Addis Ababa Ethiopia: a multicentere longitudinal study | Tekletsadik, Y. A. Workineh, S. A. Gesso, A. S. Hirbo, H. S. | BMC Anesthesiol | 2024 |
Humans |
| Effect of optimizing cerebral oxygen saturation on postoperative delirium in older patients undergoing one-lung ventilation for thoracoscopic surgery | Teng, P. Liu, H. Xu, D. Feng, X. Liu, M. Wang, Q. | J Int Med Res | 2024 |
Humans |
| Persistent delirium is associated with cerebrospinal fluid markers of neuronal injury | Tsui, A. Johnstone, B. Heslegrave, A. Zetterberg, H. Watne, L. O. Neerland, B. E. Krogseth, M. Cunningham, C. MacLullich, A. Muniz Terrera, G. Davis, D. Caplan, G. | Brain Commun | 2024 |
CSF biomarkers |
| A Retrospective Study Establishing a Nomogram Predictive Model for Postoperative High-Activity Delirium After Non-Cardiac Surgery | Tu, Y. Du, W. Pan, Y. Zhang, X. Mo, Y. Sun, C. Wang, J. | Neuropsychiatr Dis Treat | 2024 |
Pacu |
| Safe Landing: Feasibility and Safety of Operating Room Extubation in Minimally Invasive Cardiac Valve Surgery | Wang, C. C. DeBose-Scarlett, A. Irlmeier, R. Ye, F. Siegrist, K. Shah, A. S. Kingeter, M. | J Cardiothorac Vasc Anesth | 2024 |
intubation duration |
| Intraoperative hypotension and postoperative delirium in elderly male patients undergoing laryngectomy: a single-center retrospective cohort study | Wang, Y. Chen, K. Ye, M. Shen, X. | Braz J Anesthesiol | 2024 |
Hypotension |
| Perioperative Risk Factors for Postoperative Delirium in Non-Dementia Older Patients after Non-Cardiac Surgery and Anesthesia: A Prospective Study | Wattanaboot, N. Kuawatcharawong, W. Permsakmesub, P. | Ann Geriatr Med Res | 2024 |
Postoperative delirium |
| Association of preoperative frailty with risk of postoperative delirium in older patients undergoing craniotomy: a prospective cohort study | Wei, L. Liu, M. Zhang, S. Chen, Y. Wu, M. Chen, X. Liu, J. He, Y. Yang, X. Xian, J. | BMC Surg | 2024 |
Humans |
| Geriatric nutritional risk index predicts postoperative delirium in elderly: A meta-analysis | Xie, S. Wu, Q. | Saudi Med J | 2024 |
Humans |
| Intensive care unit interventions to promote sleep and circadian biology in reducing incident delirium: a scoping review | Wilcox, M. E. Burry, L. Englesakis, M. Coman, B. Daou, M. van Haren, F. M. Ely, E. W. Bosma, K. J. Knauert, M. P. | Thorax | 2024 |
Humans |
| Theory-based and evidence-based nursing interventions for the prevention of ICU-acquired weakness in the intensive care unit: A systematic review | Xu, Q. Tan, J. Wang, Y. Tang, M. | PLoS One | 2024 |
Humans |
| Transradial versus transfemoral access for middle meningeal artery embolization: Choice of the access route considering delirium in the elderly | Yamamoto, M. Fujiwara, G. Takezawa, H. Uzura, Y. Yokoya, S. Oka, H. | Surg Neurol Int | 2024 |
Chronic subdural hematoma |
| The effect of perioperative dexmedetomidine on postoperative delirium in adult patients undergoing cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis of randomized controlled trials | Zhuang, X. Fu, L. Luo, L. Dong, Z. Jiang, Y. Zhao, J. Yang, X. Hei, F. | BMC Anesthesiol | 2024 |
Adult |
| Incidence and associated factors of delirium after primary total joint arthroplasty in elderly patients: A systematic review and meta-analysis | Zhang, Y. Yu, Y. Han, Z. Diao, L. Zhao, R. Liu, J. Luo, Y. Wu, H. Yang, Y. | Medicine (Baltimore) | 2024 |
Aged |
| The effect of two different modes of anaesthesia maintenance on postoperative delirium in elderly patient with low preoperative mini-cog score | Duran, H. T. Kızılkaya, M. Aydinli, A. Osmantevfik, S. Taştan, S. Kılınç, OÖ Pirhan, Y. | BMC Anesthesiol | 2024 |
Aged |
| Extracellular Vesicle MicroRNAs as Predictive Biomarkers in Postoperative Delirium After Spine Surgery: Preliminary Study | Cho, Y. E. Kim, J. Vorn, R. Cho, H. Baek, W. Park, H. Yun, S. Kim, H. S. Cashion, A. K. Gill, J. Koo, B. N. Lee, H. | J Gerontol A Biol Sci Med Sci | 2024 |
Humans |
| Exploring the role of calf circumference as a predisposing factor for intra-hospital delirium: investigating potential gender differences: revealing potential gender variances | Ceolin, C. Papa, M. V. Simonato, C. Cazzavillan, S. Vergadoro, M. Trapella, G. S. Sermasi, R. De Rui, M. Noale, M. Zanforlini, B. M. Curreri, C. Bertocco, A. Devita, M. Sergi, G. Coin, A. | BMC Geriatr | 2024 |
Humans |
| Neurophysiological patterns reflecting vulnerability to delirium subtypes: a resting-state EEG and event-related potential study | Boord, M. S. Feuerriegel, D. Coussens, S. W. Davis, D. H. J. Psaltis, P. J. Garrido, M. I. Bourke, A. Keage, H. A. D. | Brain Commun | 2024 |
Eeg |
| Delirium in Lower Limb Trauma: The Incidence and Risk Factors in a Prospective Observational Study | Balachandran, A. Nagar, M. Behera, P. Kashyap, P. | Indian J Orthop | 2024 |
adults |
| Diurnal variation of postoperative delirium in elderly patients undergoing esketamine anesthesia for elective noncardiac surgery: a randomized clinical trial | Zhang, Y. Chen, R. Tang, S. Sun, T. Yu, Y. Shi, R. Wang, K. Zeng, Z. Liu, X. Meng, Q. Xia, Z. | Int J Surg | 2024 |
Humans |
| Recent developments in delirium after oral and maxillofacial free-flap reconstruction | Zhang, R. Zhang, W. Ren, Y. Yu, J. Li, L. Zhang, Y. | J Stomatol Oral Maxillofac Surg | 2024 |
Oral and maxillofacial free-flap reconstruction |
| A longitudinal multimodal MRI study of the visual network in postoperative delirium | Zhang, G. Qi, B. Li, H. Zhang, X. Chen, J. Li, H. Jing, B. Huang, H. | Brain Imaging Behav | 2024 |
Frontal glioma |
| Association between Intraoperative Hypotension and Postoperative Delirium: A Retrospective Cohort Analysis | Zarour, S. Weiss, Y. Abu-Ghanim, M. Iacubovici, L. Shaylor, R. Rosenberg, O. Matot, I. Cohen, B. | Anesthesiology | 2024 |
Humans |
| Incidence and relative risk of delirium after major surgery for patients with pre-operative depression: a systematic review and meta-analysis | Diep, C. Patel, K. Petricca, J. Daza, J. F. Lee, S. Xue, Y. Kremic, L. Xiao, M. Z. X. Pivetta, B. Vigod, S. N. Wijeysundera, D. N. Ladha, K. S. | Anaesthesia | 2024 |
delirium |
| Pharmacologic Treatment Strategies for Delirium in Hospitalized Adults: Past, Present, and Future | Devlin, J. W. | Semin Neurol | 2024 |
Delirium Cognitive decline Non-pharmacological interventions Risk factors ICU Delirium |
| Reperfusion therapy and risk of post-stroke delirium | Czyzycki, M. Pera, J. Dziedzic, T. | Neurol Res | 2024 |
Delirium |
| Implementation of delirium screening in the emergency department: A qualitative study with early adopters | Chary, A. N. Bhananker, A. R. Brickhouse, E. Torres, B. Santangelo, I. Godwin, K. M. Naik, A. D. Carpenter, C. R. Liu, S. W. Kennedy, M. | J Am Geriatr Soc | 2024 |
delirium |
| Practical prognostic tools to predict the risk of postoperative delirium in older patients undergoing cardiac surgery: visual and dynamic nomograms | Bah, C. S. Mbambara, B. Xie, X. Li, J. Iddi, A. K. Chen, C. Jiang, H. Feng, Y. Zhong, Y. Zhang, X. Xia, H. Yan, L. Si, Y. Zhang, J. Zou, J. | J Clin Monit Comput | 2024 |
Cardiac surgery |
| Validation of the delirium diagnostic tool-provisional (DDT-Pro) in geriatric medical inpatients with diagnostic permutations of the 3Ds with and without delirium | Botero Urrea, M. González, M. C. Villa García, M. M. Alviz Núñez, M. Velásquez-Tirado, J. D. Ocampo, M. V. Trzepacz, P. T. Franco, J. G. | J Psychosom Res | 2024 |
Humans Female |
| Delirium Mediated the Association Between a History of Falls and Short-Term Mortality Risk in Critically Ill Ischemic Stroke Patients | Cheng, H. Xu, X. Tang, Y. Yang, X. Ling, Y. Tan, S. Wang, Z. Ming, W. K. Lyu, J. | Clin Nurs Res | 2024 |
Icu |
| Risk factors for postoperative delirium in frail elderly patients undergoing on-pump cardiac surgery and development of a prediction model-a prospective observational study | Ding, Y. Gao, J. Ge, Y. Huang, T. Zhang, Y. | Front Cardiovasc Med | 2024 |
cardiac surgery |
| Effect of intra-operative Magnesium sulphate on the occurrence of post-operative delirium and insomnia in patients undergoing lumbar fixation: a randomized controlled trial | Fathy, W. Hussein, M. Elanwar, R. Elmoutaz, H. Abdelsadek, D. A. Kassim, D. Y. | BMC Anesthesiol | 2024 |
Humans |
| Predicting postoperative delirium assessed by the Nursing Screening Delirium Scale in the recovery room for non-cardiac surgeries without craniotomy: A retrospective study using a machine learning approach | Giesa, N. Haufe, S. Menk, M. Weiß, B. Spies, C. D. Piper, S. K. Balzer, F. Boie, S. D. | PLOS Digit Health | 2024 |
Postoperative Delirium Risk factors Non-linear machine learning Fluctuation Recovery Nurse Screening Delirium Scale |
| A Comparative Analysis of the Effects of Haloperidol and Dexmedetomidine on QTc Interval Prolongation during Delirium Treatment in Intensive Care Units | Haspolat, A. Polat, F. Köprülü, AŞ | J Crit Care Med (Targu Mures) | 2024 |
QTc interval |
| Effect of mannitol on postoperative delirium in patients undergoing coronary artery bypass graft: a randomised controlled trial | Hemmati Maslakpak, M. Negargar, S. Farbod, A. Khalili, A. Bilehjani, E. Alinejad, V. Faravan, A. | Open Heart | 2024 |
Humans |
| Assessing Delirium Severity in Dementia: Item Development and Psychometric Validation for a Delirium Severity Instrument | Hshieh, T. Schulman-Green, D. Fong, T. G. Metzger, E. Arias, F. Helfand, B. Marcantonio, E. Schmitt, E. Tabloski, P. Jones, R. N. Inouye, S. K. | J Gerontol Nurs | 2024 |
Humans |
| The development of a family-led novel intervention for delirium prevention and management in the adult intensive care unit: A co-design qualitative study | Johnson, G. U. Towell-Barnard, A. McLean, C. Ewens, B. | Aust Crit Care | 2024 |
Co-design |
| Disparities in Delirium across the Continuum of Care and Associations with Social Determinants of Health | Khanna, A. Govil, M. Ayele, N. Saadi, A. | Semin Neurol | 2024 |
Delirium identification Delirium treatment Disparities Social-ecological model Social determinants of health |
| The effect of non-steroidal anti-inflammatory drugs on postoperative delirium: a meta-analysis | Kim, S. Y. Na, H. S. Ryu, J. H. Shin, H. J. | Korean J Anesthesiol | 2024 |
Cognitive dysfunction |
| Management of delirium in acute stroke patients: a position paper by the Austrian Stroke Society on prevention, diagnosis, and treatment | Kneihsl, M. Berger, N. Sumerauer, S. Asenbaum-Nan, S. Höger, F. S. Gattringer, T. Enzinger, C. Aigner, M. Ferrari, J. Lang, W. | Ther Adv Neurol Disord | 2024 |
acute stroke |