John Newman, MD, PhD is a geriatrician, translational scientist, and educator at the Buck Institute for Research on Aging and in the Division of Geriatrics at UCSF. As a physician-scientist, Dr. Newman’s goal is to use our growing understanding of fundamental mechanisms of aging to better understand the pathophysiology of delirium and ultimately create new therapies to prevent, treat, and mitigate the long-term consequences of delirium on the health and independence of older adults.
His laboratory focuses on small molecule energy metabolites such as ketone bodies and nicotinamide adenine dinucleotide+ (NAD+) that have core energy metabolism functions but also interact with various mechanisms of aging. He studies how these immunometabolic pathways impact vulnerability to delirium and the acute pathophysiology of delirium using mouse models and biospecimens from human studies.
Dr. Newman is an NIA Beeson Scholar, co-leads the NIA-funded Geroscience Education and Training Network, and has contributed to NIDUS white papers on animal models for delirium. He is among leadership in both the UCSF Pepper Center and the UCSF Bakar Aging Research Institute. He is devoted to fostering a diverse and inclusive research program. His clinical work is on the inpatient geriatric medicine and internal medicine services at the San Francisco VA.