Demonstration Projects Program Request for Applications – Letter of Intent due September 16, 2022

The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory (U54AG063546) was established in 2019 to build the nation’s capacity to conduct pragmatic clinical trials (ePCTs) of non-pharmacological interventions embedded within health care systems to improve the care of people living with AD/ADRD and their care partners.

NIA (IMPACT) Collaboratory secreenshot

The NIA IMPACT Collaboratory will fund up to two Demonstration Projects (maximum duration 18 months) designed as full-scale, Stage IV effectiveness ePCTs (based on the NIH Stage Model) that test, measure, and evaluate the effect of a care delivery intervention program in a health care system for people living with AD/ADRD and their care partners. The goal of the Demonstration Project is to generate evidence on effective care delivery practices that can be expanded and/or implemented in other systems. The IMPACT Collaboratory will give preference to applications for Demonstration Projects that address dementia care for populations historically marginalized or underrepresented in clinical trials and those that promote health equity.

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