NIDUS Delirium Bibliography

Delirium Bibliography books graphic What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title: Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial

Authors: Neerland, B. E. Busund, R. Haaverstad, R. Helbostad, J. L. Landsverk, S. A. Martinaityte, I. Norum, H. M. Ræder, J. Selbaek, G. Simpson, M. R. Skaar, E. Skjærvold, N. K. Skovlund, E. Slooter, A. J. Svendsen Ø, S. Tønnessen, T. Wahba, A. Zetterberg, H.

Year: 2022

Journal: BMJ Open

Abstract: INTRODUCTION: Postoperative delirium is common in older cardiac surgery patients and associated with negative short-term and long-term outcomes. The alpha-2-adrenergic receptor agonist dexmedetomidine shows promise as prophylaxis and treatment for delirium in intensive care units (ICU) and postoperative settings. Clonidine has similar pharmacological properties and can be administered both parenterally and orally. We aim to study whether repurposing of clonidine can represent a novel treatment option for delirium, and the possible effects of dexmedetomidine and clonidine on long-term cognitive trajectories, motor activity patterns and biomarkers of neuronal injury, and whether these effects are associated with frailty status. METHODS AND ANALYSIS: This five-centre, double-blind randomised controlled trial will include 900 cardiac surgery patients aged 70+ years. Participants will be randomised 1:1:1 to dexmedetomidine or clonidine or placebo. The study drug will be given as a continuous intravenous infusion from the start of cardiopulmonary bypass, at a rate of 0.4 µg/kg/hour. The infusion rate will be decreased to 0.2 µg/kg/hour postoperatively and be continued until discharge from the ICU or 24 hours postoperatively, whichever happens first.Primary end point is the 7-day cumulative incidence of postoperative delirium (Diagnostic and Statistical Manual of Mental Disorders, fifth edition). Secondary end points include the composite end point of coma, delirium or death, in addition to delirium severity and motor activity patterns, levels of circulating biomarkers of neuronal injury, cognitive function and frailty status 1 and 6 months after surgery. ETHICS AND DISSEMINATION: This trial is approved by the Regional Committee for Ethics in Medical Research in Norway (South-East Norway) and by the Norwegian Medicines Agency. Dissemination plans include publication in peer-reviewed medical journals and presentation at scientific meetings. TRIAL REGISTRATION NUMBER: NCT05029050.

PMID: 35725264

Keywords: Adrenergic alpha-2 Receptor Agonists/therapeutic use
Aged
*Cardiac Surgical Procedures/adverse effects
Clonidine/therapeutic use
*Cognitive Dysfunction/etiology
*Delirium/diagnosis/etiology/prevention & control
*Dexmedetomidine/therapeutic use
Double-Blind Method
*Frailty/complications
Humans
Multicenter Studies as Topic
Randomized Controlled Trials as Topic
adult anaesthesia
cardiac surgery
delirium & cognitive disorders
geriatric medicine

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Total Records Found: 5967, showing 100 per page
Title	Authors	Journal	Year	Keywords
Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery: A Randomized Clinical Trial	Jiang, J. L. Zhang, L. He, L. L. Yu, H. Li, X. F. Dai, S. H. Yu, H.	Anesth Analg	2022
The Effect of Scenario-Based Learning on the Performance of Nurses Regarding Delirium in Cardiac Surgery Intensive Care Units: A Quasi-Experimental Study	Jahanbazi, A. Jokar, F. Kheirollahi, N.	Iran J Nurs Midwifery Res	2022	Delirium Nurses intensive care unit simulation training thoracic surgery
Influence of cardioplegic solution on incidence of delirium after CABG surgery: Use of Calafiore blood cardioplegia versus HTK - Bretschneider - solution in a single-center retrospective analysis from 2017 to 2021	Irqsusi, M. Loos, D. Dielmann, K. Ramzan, R. Wulf, H. Ghazy, T. Vogt, S. Rastan, A. J.	J Card Surg	2022	CABG procedure cardioplegia delirum open heart surgery
Should neuroleptics be used in patients with delirium seen by palliative care?	Hui, D. Agar, M. Maeda, I.	J Pain Symptom Manage	2022	antipsychotic agents confusion delirium drug therapy inpatients palliative care
Risk factors for postoperative delirium in elderly urological patients: A meta-analysis	Hua, Y. Chen, S. Xiong, X. Lin, C. Li, D. Tu, P.	Medicine (Baltimore)	2022	Aged Anesthesia, General/adverse effects Delirium/epidemiology/etiology/prevention & control Humans Male Postoperative Complications/etiology Risk Factors
Successful aging after elective surgery II: Study design and methods	Hshieh, T. T. Schmitt, E. M. Fong, T. G. Arnold, S. Cavallari, M. Dickerson, B. C. Dillon, S. T. Jones, R. N. Libermann, T. A. Marcantonio, E. R. Pascual-Leone, A. Shafi, M. M. Touroutoglou, A. Travison, T. G. Gou, R. Y. Tommet, D. Abdeen, A. Earp, B. Kun	J Am Geriatr Soc	2022	biomarkers cognitive decline cognitive impairment delirium dementia long-term cognitive decline
Overestimation of the Causal Effects of Medications on Delirium During Postoperative Hospital Days	Hindman, B. J. Dexter, F.	Anesth Analg	2022	Humans *Delirium/chemically induced/diagnosis Postoperative Period Hospitals Postoperative Complications/chemically induced/diagnosis Risk Factors
A new medication-based prediction score for postoperative delirium in surgical patients: Development and proof of feasibility in a retrospective patient cohort	Hindelang, V. Dimitriadis, K. Saller, T. Golla, K. Mannell, H. Hug, M. J. Strobach, D.	Pharmazie	2022	Humans Male Aged Retrospective Studies Feasibility Studies Postoperative Complications Delirium/chemically induced/diagnosis/epidemiology Risk Factors Cholinergic Antagonists
Forecasting Postoperative Delirium in Older Adult Patients with Fast-and-Frugal Decision Trees	Heinrich, M. Woike, J. K. Spies, C. D. Wegwarth, O.	J Clin Med	2022	clinical data prediction fast-and-frugal decision trees medical decision making postoperative delirium postoperative outcomes
Association of Delirium Incidence with Visitation Restrictions due to COVID-19 Pandemic in Patients with Acute Cerebrovascular Disease in a Stroke-Unit Setting: A Retrospective Cohort Study	Hahn, M. Gröschel, S. Gröschel, K. Uphaus, T.	Gerontology	2022	COVID-19 pandemic Cerebrovascular disease Delirium Stroke Stroke unit Visitation restrictions
Nurses' assessment of subsyndromal delirium and barriers to assessment: A cross-sectional survey in the intensive care unit	Gao, Y. Zhang, C. Liao, C. Gan, X.	J Nurs Manag	2022	barriers intensive care units nurses subsyndromal delirium
Anxiety as a Risk Factor for Postoperative Delirium in Elective Spine Deformity Surgeries: A National Database Study	Freedman, Z. Hudock, N. Hallan, D. R. Kelleher, J.	Cureus	2022	anxiety delirium elective surgical procedures post-operative care spine surgery
Presurgical diffusion metrics of the thalamus and thalamic nuclei in postoperative delirium: A prospective two-centre cohort study in older patients	Fislage, M. Winzeck, S. Stamatakis, E. Correia, M. M. Preller, J. Feinkohl, I. Spies, C. D. Hendrikse, J. J. C. Slooter A Winterer, G. Pischon, T. Menon, D. K. Zacharias, N.	Neuroimage Clin	2022	Diffusion kurtosis imaging Diffusion magnetic resonance imaging Neuroscience and Neuroanaesthesia Postoperative delirium Thalamic function
Long-Term Intensive Care Unit (ICU) Stays Can Lead to Long-Term Cognitive Impairment (LTCI): Neurosurgery Nursing Strategies to Minimize Risk	Fiani, B. Figueras, R. A. Samones, P. Lee, C. Castillo, A. Sangalang, B. Garcia Perez, F.	Cureus	2022	cognitive impairment delirium dementia intensive care unit long-term cognitive impairment neural processes neuro-critical care nursing education nursing strategies
Future without delirium: not quite there yet but we can start by prescribing touch	Fernandes, S. M. Adão-Serrano, M. Rodrigues, A. R. Belo, P.	Crit Care	2022	Humans Touch Delirium/drug therapy Critical Care
Using Music for the Prevention of Delirium in Patients After Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial	Esfahanian, F. Mirmohammadsadeghi, A. Gholami, H. Neshat, S. Mansouri, M. Sadeghi, M. Bathaie, S. R. Heidari, Z. Mirmohammadsadeghi, M.	J Cardiothorac Vasc Anesth	2022	clinical trial coronary artery bypass graft surgery critical care unit delirium screening music listening
The association of chronic pain and postoperative delirium: a prospective observational cohort study	Eckert, S. C. Spies, C. D. Mörgeli, R. Kruppa, J. Heinrich, M.	Minerva Anestesiol	2022
Functional brain network and trail making test changes following major surgery and postoperative delirium: a prospective, multicentre, observational cohort study	Ditzel, F. L. van Montfort, S. J. T. Vernooij, L. M. Kant, I. M. J. Aarts, E. Spies, C. D. Hendrikse, J. Slooter, A. J. C. van Dellen, E.	Br J Anaesth	2022	brain network cognitive impairment connectivity delirium encephalopathy fMRI functional brain network major surgery postoperative delirium
Comparison of Intravenous and Inhalational Anesthetic on Postoperative Cognitive Outcomes in Elderly Patients Undergoing Cancer Surgery: Systematic Review and Meta-analysis	Ding, Y. Yu, J. Cui, F. Li, J.	J Perianesth Nurs	2022	Aged Anesthetics, Inhalation/adverse effects Anesthetics, Intravenous/adverse effects Cognition Delirium/epidemiology Humans *Neoplasms/surgery Postoperative Complications/epidemiology meta-analysis neoplasms propofol sevoflurane
Examining Subjective Psychological Experiences of Postoperative Delirium in Older Cardiac Surgery Patients	Cohen, C. L. Atkins, K. J. Evered, L. A. Silbert, B. S. Scott, D. A.	Anesth Analg	2022
Instruments to measure postintensive care syndrome: a scoping review protocol	Chu, Y. Timmins, F. Thompson, D. Eustace-Cook, J.	BMJ Open	2022	Adult Critical Illness Humans Research Design Review Literature as Topic Systematic Reviews as Topic Adult intensive & critical care Anxiety disorders Covid-19 Delirium & cognitive disorders Physiology Protocols & guidelines Scholarship Scheme.
Leucine-rich glioma-inactivated 1 antibody encephalitis as a rare cause of delirium	Ching, E. Murdoch, H. Mohammed, H.	Geriatr Gerontol Int	2022
A novel semiautomatic Chinese keywords instrument screening delirium based on electronic medical records	Chen, L. Li, N. Zheng, Y. Gao, L. Ge, N. Xie, D. Yue, J.	BMC Geriatr	2022	Aged Aged, 80 and over Delirium/diagnosis Electronic Health Records Humans Male Mass Screening Psychometrics Reproducibility of Results Delirium Diagnosis Emr Keywords scale Reliability Screen Validity
Effect of Preoperative Oral Saline Administration on Postoperative Delirium in Older Persons: A Randomized Controlled Trial	Chen, J. Xie, S. Chen, Y. Qiu, T. Lin, J.	Clin Interv Aging	2022	Humans Aged Aged, 80 and over Saline Solution Postoperative Complications/prevention & control/epidemiology Delirium/epidemiology/prevention & control/diagnosis Elective Surgical Procedures/adverse effects Incidence older persons postoperative delirium spinal canal decompression
Frailty and delirium in hospitalized older adults: A systematic review with meta-analysis	Cechinel, C. Lenardt, M. H. Rodrigues, J. A. M. Binotto, M. A. Aristides, M. M. Kraus, R.	Rev Lat Am Enfermagem	2022	Humans Aged Frailty/epidemiology Frail Elderly Hospitalization Risk Factors Delirium/epidemiology
QEEG abnormalities in cognitively unimpaired patients with delirium	Carrarini, C. Calisi, D. De Rosa, M. A. Di Iorio, A. D'Ardes, D. Pellegrino, R. Gazzina, S. Pilotto, A. Arighi, A. Carandini, T. Cagnin, A. Mozzetta, S. Gallucci, M. Bonifati, D. M. Costa, C. D'Antonio, F. Bruno, G. Cipollone, F. Babiloni, C. Padovani, A.	J Neurol Neurosurg Psychiatry	2022	Cognition Eeg Neurophysiology
Prediction models for postoperative delirium after cardiac surgery: Systematic review and critical appraisal	Cai, S. Li, J. Gao, J. Pan, W. Zhang, Y.	Int J Nurs Stud	2022	Cardiac surgery Intensive care unit Postoperative delirium Prediction model declare.
Implementing a Delirium Risk Stratification Tool and Rounds to Identify and Prevent Delirium in Hospitalized Older Adults	Byrnes, T. Woodward, J.	J Nurs Care Qual	2022
The Assessment of Immediate Postoperative Delirium in Neurologically Intact Adult Patients Admitted to the Post-anesthesia Care Unit: A Cross-Sectional Study	Burad, J. Date, R. Al Ismaili, M. Sharma, P. Kuriakose, N. Kodange, S. Birur, S. K. Al Yaqoubi, K. Al Mawali, A. Padmalayan, A. El Mady, H. Elawdy, M. Jaju, S. Al Abady, A.	Cureus	2022	anesthesia recovery period cam-icu delayed awakening from anesthesia post-anesthesia discharge postoperative delirium premedication rass
Deconstructing delirium in the post anaesthesia care unit	Banerji, A. Sleigh, J. W. Voss, L. J. Garcia, P. S. Gaskell, A. L.	Front Aging Neurosci	2022	3d-cam PACU delirium anesthesia attention cognition disorganized thinking
Association between remimazolam and postoperative delirium in older adults undergoing elective cardiovascular surgery: a prospective cohort study	Aoki, Y. Kurita, T. Nakajima, M. Imai, R. Suzuki, Y. Makino, H. Kinoshita, H. Doi, M. Nakajima, Y.	J Anesth	2022	Cardiovascular surgical procedures Cognitive dysfunction Mental status and dementia tests Postintensive care unit delirium Remimazolam sedation
Haloperidol for the Treatment of Delirium in ICU Patients	Andersen-Ranberg, N. C. Poulsen, L. M. Perner, A. Wetterslev, J. Estrup, S. Hästbacka, J. Morgan, M. Citerio, G. Caballero, J. Lange, T. Kjær, M. N. Ebdrup, B. H. Engstrøm, J. Olsen, M. H. Oxenbøll Collet, M. Mortensen, C. B. Weber, S. O. Andreasen, A	N Engl J Med	2022
Needs assessment survey of healthcare providers' perceptions and practices regarding delirium prevention at a university medical center	Alghamdi, B. Koroukian, S. M. Kresevic, D. Drummond, C. K.	Front Aging	2022	assessment delirium documentation management prevention survey
Incidence, Associated Factors, and Outcome of Delirium among Patients Admitted to ICUs in Oman	Al-Hoodar, R. K. Lazarus, E. R. Al Omari, O. Al Zaabi, O.	Crit Care Res Pract	2022
Dose-dependent relationship between intra-procedural hypoxaemia or hypocapnia and postoperative delirium in older patients	Ahrens, E. Tartler, T. M. Suleiman, A. Wachtendorf, L. J. Ma, H. Chen, G. Kendale, S. M. Kienbaum, P. Subramaniam, B. Wagner, S. Schaefer, M. S.	Br J Anaesth	2022	haemodynamics hypocapnia hypoxaemia mechanical ventilation postoperative cognitive complications postoperative delirium
The Preventive Effect of Dexmedetomidine Against Delirium in Patients with Aortic Dissection: A Retrospective Cohort Study	Zhang, S. Yin, Q. Wang, Y. Yu, K. Shen, P.	Heart Surg Forum	2022	Aneurysm, Dissecting/complications/surgery Critical Care Delirium/epidemiology/etiology/prevention & control *Dexmedetomidine/therapeutic use Humans Retrospective Studies
Prediction model for delirium in patients with cardiovascular surgery: development and validation	Xu, Y. Meng, Y. Qian, X. Wu, H. Liu, Y. Ji, P. Chen, H.	J Cardiothorac Surg	2022	Calibration Cardiovascular surgery Delirium Discrimination Nomogram model
Knowledge, attitudes and practices of ICU nurses regarding subsyndromal delirium among 20 hospitals in China: a descriptive cross-sectional survey	Xing, H. Zhu, S. Liu, S. Xia, M. Jing, M. Dong, G. Ni, W. Li, L.	BMJ Open	2022	Attitude of Health Personnel Clinical Competence Cross-Sectional Studies Delirium Health Knowledge, Attitudes, Practice Hospitals Humans Intensive Care Units Nurses *Nursing Staff, Hospital/education Surveys and Questionnaires Delirium & cognitive disorders EDUCATION & TRAINING (see Medical Education & Training) Intensive & critical care
The prevention of delirium in elderly surgical patients with obstructive sleep apnea (PODESA): a randomized controlled trial	Wong, J. Doherty, H. R. Singh, M. Choi, S. Siddiqui, N. Lam, D. Liyanage, N. Tomlinson, G. Chung, F.	BMC Anesthesiol	2022	Acetaminophen Aged Arthroplasty, Replacement, Hip/adverse effects Arthroplasty, Replacement, Knee/adverse effects Delirium/epidemiology/etiology/prevention & control Female Humans Male Sleep Apnea Syndromes *Sleep Apnea, Obstructive/complications Delirium Elderly Home sleep apnea tests Obstructive sleep apnea Older adults Positive airway pressure Postoperative Merck Inc. outside of the submitted work. JW is supported by a Merit Research Award from the Department of Anesthesia, University of Toronto. SC reports non-monetary equipment support from CogState LLC, not related to this project. FC reports research support from the University Health Network Foundation and UpToDate royalties and STOP-Bang proprietary to the University Health Network. The other authors report no competing interests.
Feasibility and potential of a bedside mini-EEG for diagnosing delirium superimposed on dementia	Wijnen, V. J. M. Oudewortel, L. van Luijtelaar, G. Witlox, J. Slooter, A. J. C. van Gool, W. A.	Clin Neurophysiol	2022	Benzodiazepines Clozapine Delirium/diagnosis *Dementia/diagnosis/psychology Electroencephalography Feasibility Studies Humans Delirium Delirium superimposed on dementia Dementia Eeg Encephalopathy Neurocognitive disorders
Recipe for primary prevention of delirium in hospitalized older patients	Vreeswijk, R. Maier, A. B. Kalisvaart, K. J.	Aging Clin Exp Res	2022	Delirium Non-pharmacological Prediction Prevention Risk
Demographic and clinical characteristics of patients with delirium: analysis of a nationwide Japanese medical database	Ueda, N. Igarashi, M. Okuyama, K. Sano, H. Takahashi, K. P. Qureshi Z Tokita, S. Ogawa, A. Okumura, Y. Okuda, S.	BMJ Open	2022	Aged Antipsychotic Agents/therapeutic use Cross-Sectional Studies Delirium/chemically induced/drug therapy/epidemiology Demography Female Haloperidol/therapeutic use Humans Japan/epidemiology Male Retrospective Studies delirium & cognitive disorders epidemiology psychiatry
Pharmacologic Management of Delirium in the Intensive Care Unit	Tiberio, P. J. Prendergast, N. T. Girard, T. D.	Clin Chest Med	2022	Delirium/drug therapy/etiology Humans Intensive Care Units Risk Factors Delirium Intensive care Mechanical ventilation Prevention Treatment previously as a consultant for Haisco Pharmaceutical Group Co., Ltd., and is on an advisory board for Lungpacer Medical Inc. The other authors have nothing to disclose.
Prevalence of Emergence Delirium and Associated Factors among Older Patients Who Underwent Elective Surgery: A Multicenter Observational Study	Tesfaye Mekonin, G. Kelbesa Olika, M. Birhanu Wedajo, M. Tolasa Badada, A. Dukessa Dubiwak, A. Tageza Ilala, T. Gebre, M. N.	Anesthesiol Res Pract	2022
Impact of combined epidural anaesthesia/analgesia on postoperative cognitive impairment in patients receiving general anaesthesia: a meta-analysis of randomised controlled studies	Teng, I. C. Sun, C. K. Ho, C. N. Wang, L. K. Lin, Y. T. Chang, Y. J. Chen, J. Y. Chu, C. C. Hsing, C. H. Hung, K. C.	Anaesth Crit Care Pain Med	2022	Adult Analgesia, Epidural/adverse effects Anesthesia, Epidural/adverse effects Anesthesia, General/adverse effects Cognitive Dysfunction Delirium Humans Pain, Postoperative/drug therapy/epidemiology Postoperative Nausea and Vomiting/epidemiology Randomized Controlled Trials as Topic Delirium Epidural anaesthesia Epidural analgesia Postoperative cognitive impairment
Computerized tool and interdisciplinary care for older patients with delirium in the emergency department: a novel model in Taiwan	Tan, T. H. Yang, T. Y. Chen, Y. M. Chung, S. Y. Liu, H. H. Yang, P. C. Kao, P. H. Peng, A. C. Shu, Y. M. Chu, Y. S. Tsai, K. T. Hsu, C. C. Ho, C. H. Lin, H. J. Huang, C. C.	Aging Clin Exp Res	2022	Computerized Confusion assessment method Delirium Delirium triage screen Emergency department Interdisciplinary Older
Use of Valproic Acid for the Management of Delirium and Agitation in the Intensive Care Unit	Swayngim, R. Preslaski, C. Dawson, J.	J Pharm Pract	2022	agitation critical care delirium valproate valproic acid
Risk Factors for Acute Postoperative Delirium in Cardiac Surgery Patients >65 Years Old	Spiropoulou, E. Samanidis, G. Kanakis, M. Nenekidis, I.	J Pers Med	2022	acute delirium alcohol use cardiac surgery hypoxemia intensive care unit design of the study in the collection, analyses, or interpretation of data in the writing of the manuscript, or in the decision to publish the results.
Systemic immune-inflammation index predicts postoperative delirium in elderly patients after surgery: a retrospective cohort study	Song, Y. Luo, Y. Zhang, F. Ma, Y. Lou, J. Li, H. Liu, Y. Mi, W. Cao, J.	BMC Geriatr	2022	Aged Cohort Studies *Delirium/diagnosis/etiology Humans Inflammation/diagnosis/etiology Prognosis Retrospective Studies Biomarker Elderly Patients Inflammation Postoperative Delirium (POD) Systemic-immune-inflammation (SII)
The influence of orthopedic surgery on the incidence of post-operative delirium in geriatric patients: results of a prospective observational study	Sircar, K. Yagdiran, A. Bredow, J. Annecke, T. Eysel, P. Scheyerer, M. J.	J Clin Orthop Trauma	2022	Arthroplasty Isoflurane Perioperative management Prevention Spinesurgery
Paternal Occupation and Delirium Risk in Older Adults: A Potential Marker of Early-Life Exposures	Shiff, H. M. Arias, F. Dufour, A. B. Carr, D. Chen, F. Gou, Y. Jones, R. Schmitt, E. Travison, T. G. Kunicki, Z. J. Okereke, O. I. Inouye, S. K.	Innov Aging	2022	Cognitive reserve Life-course analysis Social determinants of health Social exposome Socioeconomic status
Flurbiprofen used in one-lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative delirium	Shen, L. Chen, J. Q. Yang, X. L. Hu, J. C. Gao, W. Chai, X. Q. Wang, D.	Front Psychiatry	2022	flurbiprofen one-lung ventilation postoperative delirium regional cerebral oxygen saturation thoracic surgery
Derivation and validation of a prediction score for postoperative delirium in geriatric patients undergoing hip fracture surgery or hip arthroplasty	Shen, J. An, Y. Jiang, B. Zhang, P.	Front Surg	2022	arthroplasty complications delirium hip fracture prognosis
Cognitive decline and dementia: does delirium matter?	Selbæk, G. Neerland, B. E.	Lancet Healthy Longev	2022	Cognitive Dysfunction Delirium *Dementia/psychology Humans interests.
Understanding why delirium is often missed in older emergency department patients: a qualitative descriptive study	Schonnop, R. Dainty, K. N. McLeod, S. L. Melady, D. Lee, J. S.	Cjem	2022	Acute care Delirium Emergency department Older people
Association between post-operative delirium and use of volatile anesthetics in the elderly: A real-world big data approach	Saller, T. Hubig, L. Seibold, H. Schroeder, Z. Wang, B. Groene, P. Perneczky, R. von Dossow, V. Hinske, L. C.	J Clin Anesth	2022	Aged [D000368] Delirium [D003693] General Anesthesia [D000768] Linear Models [D016014] Machine Learning [D000069550] Post anesthesia nursing [D016528] Volatile Anesthetics [D018685]
Risk Factors for Postoperative Delirium Identified	Rosenberg, K.	Am J Nurs	2022	Delirium/etiology Humans Postoperative Complications/etiology Risk Factors
Delirium-associated medication in people at risk. A systematic update review, meta-analyses and GRADE-profiles	Reisinger, M. Reininghaus, E. Z. De Biasi, J. Fellendorf, F. T. Schoberer, D.	Acta Psychiatr Scand	2022	Statements deliriogenic delirium drug associated delirium medication meta-analysis systematic review
The Predictive Role of Inflammatory Biochemical Markers in Post-Operative Delirium After Vascular Surgery Procedures	Pasqui, E. de Donato, G. Brancaccio, B. Casilli, G. Ferrante, G. Cappelli, A. Palasciano, G.	Vasc Health Risk Manag	2022	Aged Aged, 80 and over Biomarkers Creatinine Delirium/diagnosis/etiology Female Humans Inflammation/diagnosis/etiology Lymphocyte Count Lymphocytes Male Neutrophils Retrospective Studies Vascular Surgical Procedures/adverse effects delirium elderly risk assessment vascular disease vascular surgery
Potential Usefulness of Blood Urea Nitrogen to Creatinine Ratio in the Prediction and Early Detection of Delirium Motor Subtype in the Intensive Care Unit	Park, W. R. Kim, H. R. Park, J. Y. Kim, H. E. Cho, J. Oh, J.	J Clin Med	2022	biomarker blood urea nitrogen to creatinine ratio critical illness delirium delirium motor subtype design of the study
Perioperative Gabapentin Use and In-Hospital Adverse Clinical Events Among Older Adults After Major Surgery	Park, C. M. Inouye, S. K. Marcantonio, E. R. Metzger, E. Bateman, B. T. Lie, J. J. Lee, S. B. Levin, R. Kim, D. H.	JAMA Intern Med	2022
Follow the Money: The Widening Coding Disparity Between Acute Encephalopathy and Delirium	Oldham, M. A.	J Acad Consult Liaison Psychiatry	2022	Brain Diseases Delirium Humans acute encephalopathy altered mental status coding delirium toxic-metabolic encephalopathy
Use of Automated Infrared Pupillometry to Predict Delirium in the Intensive Care Unit: A Prospective Observational Study	Okamoto, S. Ishizawa, M. Inoue, S. Sakuramoto, H.	SAGE Open Nurs	2022	automated infrared pupillometry delirium dilation velocity intensive care delirium screening checklist subsyndromal delirium
The Role of High Sensitivity C-reactive Protein to Predict Delirium Persistence in Elderly Patients with Pneumonia: A Prospective Cohort Study	Mulyana, R. Syafrita, Y. Ali, H. Murni, A. W.	Acta Med Indones	2022	Aged Attention Biomarkers C-Reactive Protein/analysis Cohort Studies Delirium/diagnosis/etiology Female Humans Male Middle Aged Pneumonia Prospective Studies Delirium persistence elderly hs-CRP pneumonia
Peripheral interleukin-6-associated microglial QUIN elevation in basolateral amygdala contributed to cognitive dysfunction in a mouse model of postoperative delirium	Mu, J. L. Liu, X. D. Dong, Y. H. Fang, Y. Y. Qiu, S. D. Zhang, F. Liu, K. X.	Front Med (Lausanne)	2022	Bla Il-6 Quin delirium microglia repeated intestinal I/R
The effect of taurine supplementation on delirium post liver transplantation: A randomized controlled trial	Mottaghi, S. Nikoupour, H. Firoozifar, M. Jalali, S. S. Jamshidzadeh, A. Vazin, A. Shafiekhani, M.	Clin Nutr	2022	Delirium Liver transplantation Solid organ transplantation Taurine related to this article.
The association of depression and postoperative delirium: we may need more information	Mestres, C. A. Quintana, E.	Interact Cardiovasc Thorac Surg	2022	Cardiac Surgical Procedures Delirium/diagnosis/etiology Depression/diagnosis Humans Postoperative Complications/etiology Risk Factors Cardiac surgery Depression Postoperative delirium
Is mood associated with perception of recovery? Preoperative depression versus postoperative delirium after cardiac surgery	Mennander, A. A.	Interact Cardiovasc Thorac Surg	2022	Cardiac Surgical Procedures/adverse effects Delirium/diagnosis/etiology Depression/diagnosis Humans Perception Postoperative Complications Prospective Studies Risk Factors Cardiac surgery Delirium Depression
An Automated Algorithm for Determining Sleep Using Single-Channel Electroencephalography to Detect Delirium: A Prospective Observational Study in Intensive Care Units	Matsui, K. Sato, N. Idei, M. Arakida, M. Seino, Y. Ishikawa, J. Y. Nakagawa, M. Akaho, R. Nishimura, K. Nomura, T.	Healthcare (Basel)	2022	critically ill patients delirium intensive care unit single-channel electroencephalography sleep under-mattress sleep monitor
Drug Choice for Hyperactive Delirium in Terminally-Ill Cancer Patients: A Nationwide Survey	Matsuda, Y. Morita, T. Oya, K. Tagami, K. Naito, A. S. Kashiwagi, H. Otani, H.	J Pain Symptom Manage	2022	Delirium/drug therapy Humans Neoplasms/complications Psychomotor Agitation Terminally Ill
Dexmedetomidine potential in attenuating postoperative delirium in elderly patients after total hip joint replacement	Lv, Y. Gu, L.	Rev Assoc Med Bras (1992)	2022
Challenges in detecting and managing mild cognitive impairment in primary care: a focus group study in Shanghai, China	Lu, Y. Liu, C. Wells, Y. Yu, D.	BMJ Open	2022	Caregivers/psychology China *Cognitive Dysfunction/diagnosis/therapy Focus Groups Humans Primary Health Care/methods delirium & cognitive disorders primary care qualitative research
The Age-adjusted Charlson Comorbidity Index predicts post-operative delirium in the elderly following thoracic and abdominal surgery: A prospective observational cohort study	Liu, J. Li, J. He, J. Zhang, H. Liu, M. Rong, J.	Front Aging Neurosci	2022	Age-adjusted Charlson Comorbidity Index elderly observational study post-operative delirium thoracic and abdominal surgery
Early alteration of peripheral blood lymphocyte subsets as a risk factor for delirium in critically ill patients after cardiac surgery: A prospective observational study	Li, X. Cheng, W. Zhang, J. Li, D. Wang, F. Cui, N.	Front Aging Neurosci	2022	CD4+ T cells cardiac surgery critical care delirium risk factors commercial or financial relationships that could be construed as a potential conflict of interest.
Association of electroencephalogram epileptiform discharges during cardiac surgery with postoperative delirium: An observational study	Li, N. Liu, X. Gao, Y. Yin, L. Zhao, W. Ma, R. Ni, X.	Front Surg	2022	cardiac surgery cardiopulmonary bypass electroencephalography epileptiform discharges postoperative delirium commercial or financial relationships that could be construed as a potential conflict of interest.
Patients' and Relatives' Experiences of Delirium in the Intensive Care Unit-A Qualitative Study	Lange, S. Mędrzycka-Dąbrowska, W. Friganović, A. Religa, D. Krupa, S.	Int J Environ Res Public Health	2022	Aged Caregivers *Delirium/epidemiology Family/psychology Female Humans Intensive Care Units Male Qualitative Research delirium family relations family-centered care patients
Survey on Current Practice of Canadian Physicians Regarding the Investigation in Older Patients with Delirium	Laguë, A. Boucher, V. Joo, P. Yadav, K. Morasse, C. Émond, M.	Can Geriatr J	2022	delirium geriatric older patients interest exist.
Clinical phenotypes of delirium in patients admitted to the cardiac intensive care unit	Ko, R. E. Kim, S. Lee, J. Park, S. Bae, D. Choi, K. H. Park, T. K. Chung, C. R. Yang, J. H.	PLoS One	2022	Delirium/epidemiology/etiology Hospital Mortality Hospitalization Humans Intensive Care Units Phenotype Retrospective Studies
Delirium, dementia, and depression (3D) assessment of older patients in the emergency department: 5-year survival analysis	Kılıçaslan, İ Thet, M. S. Karahacıoğlu, B. Sevim, M. Ülger, Z. Aslaner, M. A. Kılıçaslan, B.	Turk J Med Sci	2022	Aged Delirium/diagnosis/epidemiology Dementia/diagnosis/epidemiology Depression/diagnosis/epidemiology Emergency Service, Hospital Geriatric Assessment Humans Prospective Studies Quality of Life Survival Analysis Delirium dementia depression geriatric emergency department older mental health disorder survival
Charles Bonnet Syndrome With Superimposed Delirium	Karson, C. Kang, C. Albrecht, B. Levin, G.	Cureus	2022	antipsychotic cbs charles bonnet syndrome charles bonnet syndrome plus deafferentation theory delirium mental health stigma perceptual release theory visual hallucination
Prevalence and Long-Term Prognosis of Post-Intensive Care Syndrome after Sepsis: A Single-Center Prospective Observational Study	Inoue, S. Nakanishi, N. Sugiyama, J. Moriyama, N. Miyazaki, Y. Sugimoto, T. Fujinami, Y. Ono, Y. Kotani, J.	J Clin Med	2022	Barthel Index Hospital Anxiety and Depression Scale Short-Memory Questionnaire delirium long-term outcome post-intensive care syndrome septic encephalopathy
Mental health-related quality of life is related to delirium in intensive care patients	Hofhuis, J. G. M. Schermer, T. Spronk, P. E.	Intensive Care Med	2022	Critical Care Delirium Follow-Up Studies Humans Intensive Care Units Prospective Studies Quality of Life Delirium Health-related quality of life Icu Mcs12 Mental health
Noise pareidolia test for predicting delirium in hospitalized older patients with cognitive decline	Hashimoto, Y. Kano, O. Ebihara, S.	Geriatr Gerontol Int	2022	cognitive decline delirium hospitalization older patients pareidolia
Postoperative Delirium Severity and Recovery Correlate With Electroencephalogram Spectral Features	Guay, C. S. Kafashan, M. Huels, E. R. Jiang, Y. Beyoglu, B. Spencer, J. W. Geczi, K. Apakama, G. Ju, Y. S. Wildes, T. S. Avidan, M. S. Palanca, B. J. A.	Anesth Analg	2022
Prevention and treatment of delirium in intensive care: Hermeneutics of experiences of the nursing team	Gómez Tovar, L. O. Henao-Castaño Á, M. Troche-Gutiérrez, I. Y.	Enferm Intensiva (Engl Ed)	2022	Critical Care Delirium/prevention & control Hermeneutics Humans Intensive Care Units Qualitative Research Atención de enfermería Delirium Hermenéutica Intensive care unit Nursing care Unidad de cuidados intensivos
How do predisposing factors differ between delirium motor subtypes? A systematic review and meta-analysis	Ghezzi, E. S. Greaves, D. Boord, M. S. Davis, D. Knayfati, S. Astley, J. M. Sharman, R. L. S. Goodwin, S. I. Keage, H. A. D.	Age Ageing	2022	Aged *Delirium/diagnosis/epidemiology Female Humans Male Psychomotor Agitation Risk Assessment Risk Factors hyperactive hypoactive mixed older people risk factor systematic review
Applying the geriatric 5Ms in critical care: the ICU-5Ms	Geen, O. Perrella, A. Rochwerg, B. Wang, X. M.	Can J Anaesth	2022	Aged Critical Care Frail Elderly Frailty Humans Intensive Care Units critical care delirium frailty geriatrics polypharmacy
Delirium in Persons With Dementia: Integrating the 4Ms of Age-Friendly Care as a Set Into the Care of Older People	Fick, D. M. Shrestha, P.	J Gerontol Nurs	2022	Aged Delirium Dementia Humans
The effect of melatonin on prevention of postoperative delirium after lower limb fracture surgery in elderly patients: a randomized double blind clinical trial	Fazel, M. R. Mofidian, S. Mahdian, M. Akbari, H. Razavizadeh, M. R.	Int J Burns Trauma	2022	Melatonin aged delirium orthopedics surgery affiliations with or involvement in any organization or entity with any financial interest (such as honoraria educational grants participation in speakers’ bureaus membership, employment, consultancies, stock ownership, or other equity interest and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.
Risk factors for delirium after surgery for craniocerebral injury in the neurosurgical intensive care unit	Chen, R. Y. Zhong, C. H. Chen, W. Lin, M. Feng, C. F. Chen, C. N	World J Clin Cases	2022	Brain injury Delirium Intensive care unit Neurosurgery Risk factors declare.
Risk factors and a nomogram model for postoperative delirium in elderly gastric cancer patients after laparoscopic gastrectomy	Chen, J. Ji, X. Xing, H.	World J Surg Oncol	2022	Aged Albumins Delirium/diagnosis/epidemiology/etiology Fibrinogen Gastrectomy/adverse effects Humans Laparoscopy/adverse effects Nomograms Postoperative Complications/etiology/surgery Retrospective Studies Risk Factors Sleep Aids, Pharmaceutical Stomach Neoplasms/complications Elderly Gastric cancer Nomogram model Postoperative delirium
Self-efficacy of caring for patients in the intensive care unit with delirium: Development and validation of a scale for intensive care unit nurses	Chang, Y. L. Hsieh, M. J. Chang, Y. C. Yeh, S. L. Chen, S. W. Tsai, Y. F.	Aust Crit Care	2022	Delirium Instrument development Intensive care unit Reliability Self-efficacy Validity
A nurse-led intervention to reduce the incidence and duration of delirium among adults admitted to intensive care: A stepped-wedge cluster randomised trial	Brennan, K. Sanchez, D. Hedges, S. Lynch, J. Hou, Y. C. Al Sayfe, M. Shunker, S. A. Bogdanoski, T. Hunt, L. Alexandrou, E. He, S. Mai, H. Rolls, K. Frost, S. A.	Aust Crit Care	2022	Delirium prevention Intensive care Nurse-led interventions Stepped-wedge cluster randomised trials
Association of cholinesterase activities and POD in older adult abdominal surgical patients	Bosancic, Z. Spies, C. D. Müller, A. Winterer, G. Piper, S. K. Heinrich, M	BMC Anesthesiol	2022	Aged Butyrylcholinesterase Cholinergic Agents Delirium/etiology Female Humans Male Postoperative Complications/diagnosis Prospective Studies Sodium Oxybate Cholinesterase activity Older adults Pod Postoperative
Management of delirium in older adults: challenges and opportunities	Bingham, K. S. Flint, A. J.		2022	Aged Delirium/diagnosis/therapy Dementia Humans
Emergence delirium after intracranial neurosurgery- a prospective cohort study	Bharadwaj, S. Konar, S. Akash, V. S. Gopalakrishna, K. N. Chakrabarti, D. Kamath, S.	J Clin Neurosci	2022	Adolescent Adult Anesthesia Recovery Period Anesthetics, Inhalation Emergence Delirium/epidemiology/etiology Humans *Neurosurgery Prospective Studies Risk Factors Emergence delirium Hyperactive delirium Hypoactive delirium Incidence Neurosurgery Risk factors
A novel approach for the detection of cognitive impairment and delirium risk in older patients undergoing spine surgery	Barreto Chang, O. L. Whitlock, E. L. Arias, A. D. Tsoy, E. Allen, I. E. Hellman, J. Bickler, P. E. Miller, B. Possin, K. L.	J Am Geriatr Soc	2022	anesthesia and surgery cognitive assessment postoperative delirium postoperative outcomes
Temporal Variability in Inflammatory Gene Methylation and Delirium in Critically Ill Patients	Alexander, S. A. Conley, Y. P. Girard, T. D. McVerry, B. J. Ren, D.	Am J Crit Care	2022	Adolescent Brain Injuries Critical Illness Delirium/genetics Female Humans Intensive Care Units Male Methylation Respiration, Artificial
Machine Learning-Based Prediction Models for Delirium: A Systematic Review and Meta-Analysis	Xie, Q. Wang, X. Pei, J. Wu, Y. Guo, Q. Su, Y. Yan, H. Nan, R. Chen, H. Dou, X.	J Am Med Dir Assoc	2022	Machine learning algorithm delirium meta-analysis predictive model systematic review
Baseline Anxiety and Depression and Risk for ICU Delirium: A Prospective Cohort Study	Wu, T. T. Kooken, R. Zegers, M. Ko, S. Bienvenu, O. J. Devlin, J. W. van den Boogaard, M.	Crit Care Explor	2022	anxiety delirium depression intensive care mental disorders interest.