What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Intravenous infusion of dexmedetomidine during the surgery to prevent postoperative delirium and postoperative cognitive dysfunction undergoing non-cardiac surgery: a meta-analysis of randomized controlled trials | Wang, D. Liu, Z. Zhang, W. Zu, G. Tao, H. Bi, C. | Eur J Med Res | 2024 |
Humans |
| Triglyceride-glucose index predicts postoperative delirium in elderly patients with type 2 diabetes mellitus: a retrospective cohort study | Sun, M. Liu, M. Zhang, F. Sang, L. Song, Y. Li, P. Liu, S. Yang, H. Ma, L. Cao, J. Mi, W. Ma, Y. | Lipids Health Dis | 2024 |
Aged |
| Electroencephalogram Biomarkers from Anesthesia Induction to Identify Vulnerable Patients at Risk for Postoperative Delirium | Pollak, M. Leroy, S. Röhr, V. Brown, E. N. Spies, C. Koch, S. | Anesthesiology | 2024 |
Humans |
| Mesial temporal atrophy in preoperative MRI rather than steep Trendelenburg position is associated with postoperative delirium in patients undergoing a major urologic surgery | Park, J. H. Park, I. Yoon, J. Sim, Y. Kim, J. Lee, S. K. Joo, B. | Int Urol Nephrol | 2024 |
Male |
| Comparison of Remimazolam and Propofol on Postoperative Delirium in Elderly Patients Undergoing Radical Resection of Colon Cancer: A Single-Center Prospective Randomized Controlled Study | Liu, T. Zhao, H. Zhao, X. Qu, M. | Med Sci Monit | 2024 |
Humans |
| Dynamic Delirium Prediction in the Intensive Care Unit using Machine Learning on Electronic Health Records | Contreras, M. Silva, B. Shickel, B. Bandyopadhyay, S. Guan, Z. Ren, Y. Ozrazgat-Baslanti, T. Khezeli, K. Bihorac, A. Rashidi, P. | IEEE EMBS Int Conf Biomed Health Inform | 2023 |
Delirium ICU Machine learning system Delirium Prediction |
| The Role of Delirium on Short- and Long-Term Postoperative Outcomes Following Major Gastrointestinal Surgery for Cancer | Katayama, E. S. Stecko, H. Woldesenbet, S. Khalil, M. Munir, M. M. Endo, Y. Tsilimigras, D. Pawlik, T. M. | Ann Surg Oncol | 2024 |
Delirium Digestive tract surgery Surgical outcomes Postoperative delirium Expenditures |
| Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial | Mart, M. F. Boehm, L. M. Kiehl, A. L. Gong, M. N. Malhotra, A. Owens, R. L. Khan, B. A. Pisani, M. A. Schmidt, G. A. Hite, R. D. Exline, M. C. Carson, S. S. Hough, C. L. Rock, P. Douglas, I. S. Feinstein, D. J. Hyzy, R. C. Schweickert, W. D. Bowton, D. L. | Lancet Respir Med | 2024 |
Delirium Critical illness Antipsychotics Long-term cognitive impairment Haloperidol Ziprasidone |
| Incidence and assessment of delirium following open cardiac surgery; A systematic review and meta-analysis | Petersson, N. B. Hansen, M. H. Hjelmborg, J. V. B. Instenes, I. Christoffersen, A. S. Larsen, K. L. Schmidt, H. Riber, L. P. S. Norekvål, T. M. Borregaard, B. | Eur J Cardiovasc Nurs | 2024 |
Open Cardiac Surgery Delirium Systematic Review CAM CAM-ICU Delirium assessment tools |
| Significance Analysis of the Improvement in Postoperative Recovery of Cardiac Surgery Patients Based on the Graded Management Established Using the Delirium Prediction Model | Zhang, H. Wang, Q. Feng, P. | Altern Ther Health Med | 2024 |
Cardiac Surgery Delirium Prediction Delirium ICU Delirium Type A aortic coarctation |
| Postoperative Delirium and the Older Adult: Untangling the Confusion | Thedim, M. Vacas, S. | J Neurosurg Anesthesiol | 2024 |
aging, anesthesia, delirium, inflammation, sleep |
| Efficacy and safety of music therapy for the treatment of anxiety and delirium in ICU patients: a meta-analysis and systematic review of randomized controlled trials | Xiao, M. Gong, C. Mai, M. Huang, M. Xiong, A. Liu, H. Jiang, R. | Minerva Anestesiol | 2024 |
Music therapy; Intensive care units; Anxiety; Delirium; Meta-analysis |
| Aripiprazole for treating delirium: A systematic review-Is it a valid yet understudied treatment? | Maddalena, S. Magistri, C. Mellini, C. Sarli, G. | J Psychopharmacol | 2024 |
Haloperidol |
| Delirium screening in the emergency department: evaluation and intervention | Meged-Book, T. Frenkel, R. Nikonov, A. Zeldetz, V. Kosto, A. Schwarzfuchs, D. Freud, T. Press, Y. | Isr J Health Policy Res | 2024 |
Humans |
| A Toolkit for Delirium Identification and Promoting Partnerships Between Carers and Nurses: A Pilot Pre-Post Feasibility Study | Aggar, C. Craswell, A. Bail, K. Compton, R. M. Hughes, M. Sorwar, G. Baker, J. Greenhill, J. Shinners, L. Nichols, B. Langheim, R. Wallis, A. Bowen, K. Bridgett, H. | J Gen Intern Med | 2024 |
caregiving |
| The role of heart rate variability in predicting delirium: A systematic review and meta-analysis | Amit Patel, K. Sethi, A. Al Azazi, E. McClurg, C. Chowdhury, T. | J Clin Neurosci | 2024 |
Delirium |
| Efficacy of melatonin in decreasing the incidence of delirium in critically ill adults: a randomized controlled trial | Bandyopadhyay, A. Yaddanapudi, L. N. Saini, V. Sahni, N. Grover, S. Puri, S. Ashok, V. | Crit Care Sci | 2024 |
Humans |
| Assessment and report of individual symptoms in studies of delirium in postoperative populations: a systematic review | Bowman, E. M. L. Sweeney, A. M. McAuley, D. F. Cardwell, C. Kane, J. Badawi, N. Jahan, N. Iqbal, H. K. Mitchell, C. Ballantyne, J. A. Cunningham, E. L. | Age Ageing | 2024 |
Humans |
| Systemic inflammation and delirium during critical illness | Brummel, N. E. Hughes, C. G. McNeil, J. B. Pandharipande, P. P. Thompson, J. L. Orun, O. M. Raman, R. Ware, L. B. Bernard, G. R. Harrison, F. E. Ely, E. W. Girard, T. D. | Intensive Care Med | 2024 |
Coma |
| Hospitalized Patients With Delirium and 28-Day Unplanned Hospital Readmissions: A Longitudinal Retrospective Cohort Study | Butala, A. Gilbert, J. M. Griffiths, A. A. Lim, W. K. | J Am Med Dir Assoc | 2024 |
Delirium |
| Validity and reliability of the Turkish version of the Informant Assessment of Geriatric Delirium Scale | Celik, B. Bilik, O. Koçbilek, Z. D. Damar, H. T. Öz, D. Denizmen, Z. | Ideggyogy Sz | 2024 |
Aged |
| Can admission Braden skin score predict delirium in older adults in the intensive care unit? Results from a multicenter study | Cheng, H. Huang, X. Yuan, S. Song, S. Tang, Y. Ling, Y. Tan, S. Wang, Z. Zhou, F. Lyu, J. | J Clin Nurs | 2024 |
Humans |
| Malnutrition-Related Health Outcomes in Older Adults with Hip Fractures: A Systematic Review and Meta-Analysis | Chiavarini, M. Ricciotti, G. M. Genga, A. Faggi, M. I. Rinaldi, A. Toscano, O. D. D'Errico, M. M. Barbadoro, P. | Nutrients | 2024 |
Humans |
| Organizational Context and Facilitation Interactions on Delirium Risk in Long-Term Care: A Cross-Sectional Study | Choroschun, K. Estabrooks, C. A. Duan, Y. Chamberlain, S. Shrestha, S. Cummings, G. G. Iaconi, A. Norton, P. G. Song, Y. Hoben, M. | J Am Med Dir Assoc | 2024 |
Organizational context |
| Delirium and delirium severity screening in the intensive care-correspondence of screenings tools | Collet, M. O. Nielsen, A. H. Larsen, L. K. Laerkner, E. Jensen, J. F. Mortensen, C. B. Lehmkuhl, L. Thorn, L. Rossen, B. S. Nielsen, T. A. Laursen, E. Shiv, L. H. Villumsen, M. Rahr, M. N. Svenningsen, H. | Aust Crit Care | 2024 |
Adult |
| A joint frailty model for recurrent and competing terminal events: Application to delirium in the ICU | Etzkorn, L. H. Coënt, Q. L. van den Boogaard, M. Rondeau, V. Colantuoni, E. | Stat Med | 2024 |
competing events |
| Nomogram for predicting the risk of postoperative delirium in elderly patients undergoing orthopedic surgery | Fan, Y. Yang, T. Liu, Y. Gan, H. Li, X. Luo, Y. Yang, X. Pang, Q. | Perioper Med (Lond) | 2024 |
Elderly patients |
| The Association of Plasma Leptin, Soluble Leptin Receptor and Total and High-Molecular Weight Adiponectin With the Risk of Perioperative Neurocognitive Disorders | Feinkohl, I. Janke, J. Slooter, A. J. C. Winterer, G. Spies, C. Pischon, T. | Am J Geriatr Psychiatry | 2024 |
Adiponectin |
| A novel nomogram for the prediction of subsyndromal delirium in patients in intensive care units: A prospective, nested case-controlled study | Gao, Y. Gan, X. | Int J Nurs Stud | 2024 |
Delirium |
| Association Between Preoperative Sleep Disturbance and Postoperative Delirium in Elderly: A Retrospective Cohort Study | Guo, H. Li, L. H. Lv, X. H. Su, F. Z. Chen, J. Xiao, F. Shi, M. Xie, Y. B. | Nat Sci Sleep | 2024 |
anesthesia |
| Validation to Spanish of nursing assessment scale for early diagnosis of delirium - Nu-DESC | Henao Castaño Á, M. Lozano González, L. M. Gómez Tovar, L. O. | Invest Educ Enferm | 2023 |
Adult |
| Predictive modeling for postoperative delirium in elderly patients with abdominal malignancies using synthetic minority oversampling technique | Hu, W. J. Bai, G. Wang, Y. Hong, D. M. Jiang, J. H. Li, J. X. Hua, Y. Wang, X. Y. Chen, Y. | World J Gastrointest Oncol | 2024 |
Abdominal cancer |
| Reliability and Validity of the Spanish Adaptation of the Stanford Proxy Test for Delirium in Two Clinical Spanish-Speaking Communities | Infante, S. Behn, A. González, M. Pintor, L. Franco, E. Araya, P. Maldonado, J. R. | J Acad Consult Liaison Psychiatry | 2024 |
Humans |
| Detection of delirium in older patients-A point prevalence study in surgical and non-surgical hospital wards | Instenes, I. Eide, L. S. P. Andersen, H. Fålun, N. Pettersen, T. Ranhoff, A. H. Rudolph, J. L. Steihaug, O. M. Wentzel-Larsen, T. Norekvål, T. M. | Scand J Caring Sci | 2024 |
4at |
| The impact of delirium on clinical and functional outcomes in hospitalized patients with acute coronary syndrome | Ioanna, D. Evangelos, F. John, S. Aikaterini, T. Ioannis, V. Dimitrios, P. Maria, S. | Nurs Crit Care | 2024 |
acute coronary syndrome |
| Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care | Jackson, G. P. Jackson, C. E. Boland, J. W. Featherstone, I. Huang, C. Ogden, M. Sartain, K. Siddiqi, N. Twiddy, M. Pearson, M. Johnson, M. J. | Palliat Med | 2024 |
Humans |
| Diffuse optical tomography for mapping cerebral hemodynamics and functional connectivity in delirium | Jiang, S. Huang, J. Yang, H. Czuma, R. Farley, L. Cohen-Oram, A. Hartney, K. Chechotka, K. Kozel, F. A. Jiang, H. | Alzheimers Dement | 2024 |
acute brain failure |
| Cognitive Training for Reduction of Delirium in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial | Jiang, Y. Xie, Y. Fang, P. Shang, Z. Chen, L. Zhou, J. Yang, C. Zhu, W. Hao, X. Ding, J. Yin, P. Wang, Z. Cao, M. Zhang, Y. Tan, Q. Cheng, D. Kong, S. Lu, X. Liu, X. Sessler, D. I. | JAMA Netw Open | 2024 |
Humans |
| Physical activity may a probably protective factor for postoperative delirium: the PNDABLE study | Kong, J. Lin, X. Wang, B. Xu, S. Wang, Y. Hua, S. Gong, H. Dong, R. Lin, Y. Li, C. Bi, Y. | Front Aging Neurosci | 2024 |
Alzheimer-related biomarkers |
| Effects of Exercise Intervention for the Management of Delirium in Hospitalized Older Adults: A Randomized Clinical Trial | Lozano-Vicario, L. Zambom-Ferraresi, F. Zambom-Ferraresi, F. L. Sáez de Asteasu M Galbete-Jiménez, A. Muñoz-Vázquez Á, J. Cedeno-Veloz, B. A. De la Casa-Marín, A. Ollo-Martínez, I. Fernández-Irigoyen, J. Santamaría, E. San Miguel Elcano, R. Ortiz | J Am Med Dir Assoc | 2024 |
delirium |
| The association between the fibrinogen-to-albumin ratio and delirium after deep brain stimulation surgery in Parkinson's disease | Lu, W. Wang, H. Lin, S. Chang, X. Wang, J. Wu, X. Yu, X. | Front Med (Lausanne) | 2024 |
Parkinson’s disease |
| The Application Value of Esketamine and Dexmedetomidine in Preventing Postoperative Delirium and Hyperalgesia in Elderly Patients with Thoracic Anesthesia | Lu, Y. Yin, G. Jin, C. Gu, K. Bao, D. Xu, W. Yang, Z. | Altern Ther Health Med | 2024 |
Humans |
| A Molecular Framework for Delirium | Lyman, K. A. | Neurohospitalist | 2024 |
attention |
| Evaluation of Delirium Among Elders in the Emergency Department: A Cross-Sectional Study | Marcomini, I. Pisoni, L. Mellino, A. Labaran, R. Milani, L. | Dimens Crit Care Nurs | 2024 |
Humans |
| A Mediation Analysis Examining High Risk, Anticholinergic Medication Use, Delirium, and Dementia After Major Surgery | Mohanty, S. Lindroth, H. Timsina, L. Holler, E. Jenkins, P. Ortiz, D. Hur, J. Gillio, A. Zarzaur, B. Boustani, M. | J Surg Res | 2024 |
Anticholinergics |
| Comparing the delirium objective structured clinical examination (OSCE) education package to standard education for post-registration nurses: A randomised controlled trial | Montgomery, A. Smerdely, P. Hickman, L. Traynor, V. | Nurse Educ Today | 2024 |
Delirium |
| Postoperative cognitive dysfunction: Review of pathophysiology, diagnostics and preventive strategies | Nešković, N. Budrovac, D. Kristek, G. Kovačić, B. Škiljić, S. | J Perioper Pract | 2024 |
Neuroinflammation |
| Prognostic implications of delirium after Left Ventricular Assist Device (LVAD) implantation: A retrospective study | Noufi, P. Anderson, K. M. Crowell, N. White, Y. Molina, E. Rao, S. D. Groninger, H. | J Acad Consult Liaison Psychiatry | 2024 |
Delirium |
| Sex Differences in Delirium after Coronary Artery Bypass Graft Surgery and Perioperative Neuropsychiatric Conditions: A Secondary Analysis of a Cohort Study | Oldham, M. A. Kukla, B. Walsh, P. Lee, H. B. | J Geriatr Psychiatry Neurol | 2024 |
coronary artery bypass graft surgery outcomes |
| Incidence of confusional syndrome (delirium) in a Latin American university hospital | Oviedo Lugo, G. F. García Martínez, P. A. Duarte Osorio, A. Rincón, C. J. López, A. Chavarría, R. Pineda Betancur, C. García Gil, N. Duarte Ariza, M. N. Patiño Trejos, J. A. Insignares, J. S. Gómez-Restrepo, C. | Rev Colomb Psiquiatr (Engl Ed) | 2024 |
Cam |
| Postoperative cognitive disorders and delirium in gynecologic surgery: Which surgery and anesthetic techniques to use to reduce the risk? | Pecorella, G. De Rosa, F. Licchelli, M. Panese, G. Carugno, J. T. Morciano, A. Tinelli, A. | Int J Gynaecol Obstet | 2024 |
anesthesia |
| Serum NFL and tau, but not serum UCHL-1 and GFAP or CSF SNAP-25, NPTX2, or sTREM2, correlate with delirium in a 3-year retrospective analysis | Piel, J. H. A. Bargemann, L. Leypoldt, F. Wandinger, K. P. Dargvainiene, J. | Front Neurol | 2024 |
Alzheimer’s disease |
| Age-stratified comorbid and pharmacologic analysis of patients with glioblastoma | Rabin, E. E. Huang, J. Kim, M. Mozny, A. Lauing, K. L. Penco-Campillo, M. Zhai, L. Bommi, P. Mi, X. Power, E. A. Prabhu, V. C. Anderson, D. E. Barton, K. P. Walunas, T. L. Schiltz, G. E. Amidei, C. Sanchez-Gomez, P. Thakkar, J. P. Lukas, R. V. Wainwright, | Brain Behav Immun Health | 2024 |
Confusion |
| Unraveling the Predictors for Delirium and ICU Stay Duration in Patients with Heart Failure and Reduced Ejection Fraction (HFrEF) Undergoing Coronary Artery Bypass Grafting-A Multicentric Analysis | Rustenbach, C. J. Reichert, S. Berger, R. Schano, J. Nemeth, A. Haeberle, H. Charotte, C. Caldonazo, T. Saqer, I. Saha, S. Schnackenburg, P. Djordjevic, I. Krasivskyi, I. Wendt, S. Serna-Higuita, L. M. Doenst, T. Hagl, C. Wahlers, T. Schlensak, C. Sandova | Biomedicines | 2024 |
Cabg |
| Validation of the Delirium Observation Screening Scale in long-term care facilities in Flanders | Sabbe, K. van der Mast, R. Dilles, T. Van Rompaey, B. | Geriatr Gerontol Int | 2024 |
delirium |
| Effect of hospital elder life program on the incidence of delirium: A systematic review and meta-analysis of clinical trials | Shen, H. Liu, X. Wu, L. Jia, J. Jin, X. | Geriatr Nurs | 2024 |
Humans |
| Impact of Delirium Onset and Duration on Mortality in Patients With Cancer Admitted to the ICU | Tao, J. Seier, K. P. Chawla, S. Tan, K. S. Wheeler, A. Sanzone, J. Marasigan-Stone, C. B. Simondac, J. S. Pascual, A. V. Kostelecky, N. T. Voigt, L. P. | J Intensive Care Med | 2024 |
ICU outcomes |
| Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials | Veronese, N. Solimando, L. Bolzetta, F. Maggi, S. Fiedorowicz, J. G. Gupta, A. Fabiano, N. Wong, S. Boyer, L. Fond, G. Dragioti, E. Dominguez, L. J. Barbagallo, M. Romagnoli, S. Bellelli, G. Solmi, M. | Ageing Res Rev | 2024 |
Delirium |
| Study on the causal relationship between educational attainment and delirium: A two-sample Mendelian randomization study | Wan, X. Yu, H. Yang, M. Hou, W. Xie, J. Xu, K. Ma, Y. Ma, R. Wang, F. Xu, P. | Heliyon | 2024 |
Delirium |
| Potential value of serum prealbumin and serum albumin in the identification of postoperative delirium in patients undergoing knee/hip replacement: an observational study and internal validation study | Wang, B. Xin, Y. Tang, X. Wang, F. Hua, S. Yang, Y. Xu, S. Gong, H. Dong, R. Lin, Y. Li, C. Lin, X. Bi, Y. | Front Neurol | 2024 |
biomarkers |
| Understanding the association between pain and delirium in older hospital inpatients: systematic review and meta-analysis | White, N. Bazo-Alvarez, J. C. Koopmans, M. West, E. Sampson, E. L. | Age Ageing | 2024 |
Humans |
| Prognostic value of Geriatric-8 for adverse outcomes within 30 days of surgery in older adults with colorectal cancer: A retrospective cohort study | Winters, A. M. Bakker, J. Ten Hoor, J. Bilo, H. J. G. Roodbol, P. F. Edens, M. A. Finnema, E. J. | Eur J Oncol Nurs | 2024 |
Cognitive decline |
| An online delirium detection tool: Cross-cultural adaptation of a Chinese version of the Family Confusion Assessment Method | Xing, H. Zhu, S. Liu, S. Xia, M. Tong, S. Li, L. Li, L. | Aust Crit Care | 2024 |
Delirium |
| Value of Flemish Version of the Triage Risk Screening Tool in Predicting Unfavorable Outcomes after Elective Cancer Surgery: A Propensity Score-Matched Retrospective Cohort Study | Yajima, S. Nakanishi, Y. Ogasawara, R. A. Imasato, N. Hirose, K. Katsumura, S. Kataoka, M. Masuda, H. | Biomed Hub | 2024 |
Delirium |
| Impact of intraoperative dexmedetomidine on postoperative delirium and pro-inflammatory cytokine levels in elderly patients undergoing thoracolumbar compression fracture surgery: A prospective, randomized, placebo-controlled clinical trial | Ye, C. Shen, J. Zhang, C. Hu, C. | Medicine (Baltimore) | 2024 |
Humans |
| Development and validation of a machine learning model to predict postoperative delirium using a nationwide database: A retrospective, observational study | Yoshimura, M. Shiramoto, H. Koga, M. Morimoto, Y. | J Clin Anesth | 2024 |
Machine learning model |
| Tau and delirium superimposed on dementia: A case report | Yu, P. C. Kuo, C. M. Chen, I. C. | SAGE Open Med Case Rep | 2024 |
Tau |
| Quetiapine Versus Haloperidol in the Management of Hyperactive Delirium: Randomized Controlled Trial | Zakhary, T. Ahmed, I. Luttfi, I. Montasser, M. | Neurocrit Care | 2024 |
Antipsychotics |
| Associations between postoperative cognitive dysfunction, serum interleukin-6 and postoperative delirium among patients after coronary artery bypass grafting: A mediation analysis | Zhang, S. Tao, X. J. Ding, S. Feng, X. W. Wu, F. Q. Wu, Y. | Nurs Crit Care | 2024 |
cardiac surgery |
| Risk prediction models for postoperative delirium in elderly patients with fragility hip fracture: A systematic review and critical appraisal | Zhou, B. Wang, A. Cao, H. | Int J Orthop Trauma Nurs | 2024 |
Humans |
| An exploratory study on the heterogeneity of postoperative delirium: Preoperative cognitive screening does not detect hallucinatory delirium risk | Yajima, S. Nakanishi, Y. Ogasawara, R. A. Imasato, N. Hirose, K. Katsumura, S. Kataoka, M. Masuda, H. | Eur J Surg Oncol | 2024 |
Humans |
| Validation of a viable delirium detection test performed by nurses and physicians during routine patient care | Soboh, R. Gino-Moor, S. Jiris, N. Ginsberg, S. Oliven, R. | BMC Geriatr | 2024 |
Humans |
| Does Comprehensive Geriatric Assessment Reduce the Incidence of Postoperative Delirium? A Quasi-experimental Study in Older Adults Undergoing Transcatheter Aortic Valve Implantation | Schwesinger, A. Tsai, L. T. Lang, W. Mantegazza, N. Bauernschmitt, R. Wilhelm, M. J. Bischoff-Ferrari, H. A. Gagesch, M. | Clin Interv Aging | 2024 |
Humans |
| Butyrylcholinesterase activity in patients with postoperative delirium after cardiothoracic surgery or percutaneous valve replacement- an observational interdisciplinary cohort study | Schlake, K. Teller, J. Hinken, L. Laser, H. Lichtinghagen, R. Schäfer, A. Fegbeutel, C. Weissenborn, K. Jung, C. Worthmann, H. Gabriel, M. M. | BMC Neurol | 2024 |
Aged |
| Diagnostic accuracy of the pediatric CAM-ICU, pre-school CAM-ICU, Pediatric Anesthesia Emergence Delirium and Cornell Assessment of Pediatric Delirium for detecting delirium in the pediatric intensive care unit: A systematic review and meta-analysis | Rohmah, I. Chen, Y. C. Lin, C. J. Tsao, N. H. Chiu, H. Y. | Intensive Crit Care Nurs | 2024 |
Humans |
| Intraoperative Use of Phenylephrine versus Ephedrine and Postoperative Delirium: A Multicenter Retrospective Cohort Study | Ma, H. Ahrens, E. Wachtendorf, L. J. Suleiman, A. Shay, D. Munoz-Acuna, R. Tartler, T. M. Teja, B. Wagner, S. Subramaniam, B. Rhee, J. Schaefer, M. S. | Anesthesiology | 2024 |
Adult |
| Effect of clock rhythm on emergence agitation and early postoperative delirium in older adults undergoing thoracoscopic lung cancer surgery: protocol for a prospective, observational, cohort study | Jiang, L. Wang, J. Chen, W. Wang, Z. Xiong, W. | BMC Geriatr | 2024 |
Humans |
| Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders | Arnsten, A. F. T. Ishizawa, Y. Xie, Z. | Mol Psychiatry | 2023 |
Humans |
| The role of perioperative sedative anesthetics in preventing postoperative delirium: a systematic review and network-meta analysis including 6679 patients | Huang, J. X. Zhang, S. S. Wang, S. X. Xi, D. S. Luo, F. R. Liu, C. J. Li, H. | BMC Cardiovasc Disord | 2024 |
PMID: 38448835 PMCID: PMC10916082 |
| Preventive Effects of Melatonin on Delirium in Intensive Care Unit Patients: A Meta-Analysis of Randomized Controlled Trials | Zhao, L. Feng, Z. Wang, Q. Jiang, Z. Qiu, X. | Altern Ther Health Med | 2024 |
ICU Delirium Melatonin Length of Stay Meta-Analysis Mechanical Ventilation |
| Mitochondrial Dysfunction of Peripheral Platelets as a Predictive Biomarker for Postoperative Delirium in Elderly Patients | Yang, Y. Zhang, W. Liu, Y. Liu, X. Xie, J. Xu, R. Huang, Y. Hao, J. Sun, Y. Gu, X. Ma, Z. | Ann Neurol | 2024 |
Postoperative Delirium Bioenergetic Health Index Surgery Mitochondria MMSE
|
| Effect of Esketamine on Postoperative Delirium in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass: A Randomized Controlled Trial | Xiong, X. Shao, Y. Chen, D. Chen, B. Lan, X. Shi, J. | Anesth Analg | 2024 |
Postoperative Delirium Esketamine Cardiac Valve Replacement Cardiopulmonary Bypass CAM CAM-ICU MMSE |
| Prolonged Hourly Neurologic Examinations are Associated with Increased Delirium and No Discernible Benefit in Mild/Moderate Geriatric Traumatic Brain Injury | Ruiz, R. A. F. Canas, M. Diaz, L. Aldana, J. A. Afzal, H. Falcon, A. F. Del Toro, D. Day, A. McCarthy, J. Stansfield, K. Bochicchio, G. V. Niziolek, G. Kranker, L. M. Rosengart, M. R. Hoofnagle, M. Leonard, J. | J Trauma Acute Care Surg | 2024 |
NeuroChecks Delirium TBI CAM-ICU |
| Association of Intravenous Neostigmine and Anticholinergics or Sugammadex with Postoperative Delirium: A Retrospective Cohort Study | Rössler, J. Abramczyk, E. Paredes, S. Anusic, N. Pu, X. Maheshwari, K. Turan, A. Ruetzler, K. | Anesth Analg | 2024 |
bCAM Postoperative Delirium Sugammadex Neostigmine Anesthesia Noncardiac Surgery |
| Metformin Use in Type 2 Diabetics and Delirium After Noncardiac Surgery: A Retrospective Cohort Analysis | Paredes, S. Harb, A. Rössler, J. Nikoo, M. Z. Ruetzler, K. Turan, A. Pu, X. Sessler, D. I. | Anesth Analg | 2024 |
Type 2 Diabetes CAM-ICU bCAM Postoperative Delirium Metformin
|
| Preoperative Intrathecal Morphine is Associated With Reduced Postoperative Pain, Agitation, and Delirium In Living Donor Kidney Transplantation Recipients | Lee, J. E. Lee, K. W. Gil, E. Park, J. B. Kim, B. J. Kim, H. Y. Kim, G. S. | Transplant Proc | 2024 |
Kidney Transplant Postoperative Delirium Intrathecal Morphine CAM-ICU Postoperative Pain Anesthesia |
| Neuropsychological follow-up of isoflurane sedated intensive care patients: a substudy of a randomized trial | Fuchs, V. F. Simon, H. V. Soldinger, N. Volk, T. Meiser, A. | Minerva Anestesiol | 2024 |
Critical care Isoflurane Propofol Delirium |
| Feasibility and Acceptability of Using Wireless Limited Polysomnography to Capture Sleep Before, During, and After Hospitalization for Patients With Planned Cardiothoracic Surgery | Cordoza, M. L. Anderson, B. J. Cevasco, M. Diamond, J. M. Younes, M. Gerardy, B. Iroegbu, C. Riegel, B. | J Cardiovasc Nurs | 2024 |
Critical Illness Intensive Care Unit Polysomnography Sleep Thoracic Surgery |
| Antipsychotics in the Treatment of Delirium in Critically Ill Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Carayannopoulos, K. L. Alshamsi, F. Chaudhuri, D. Spatafora, L. Piticaru, J. Campbell, K. Alhazzani, W. Lewis, K. | Crit Care Med | 2024 |
Antipsychotic medication Delirium Systematic review Critically Ill Cognitive Impairment Coma |
| Burnout and perceived burden levels related to delirium in physicians and nurses | Yamagata, H. Takihara, T. Kobayashi, R. Hirose, K. Higuchi, K. Miyahara, M. Komatsu, D. | Gen Hosp Psychiatry | 2024 |
Humans |
| Bell's mania as a clinical presentation in a neurosurgical setting from a tertiary care neuropsychiatric hospital in India | Mamtani, H. Utagi, S. Chaurasia, K. K. Reddy, P. V. Arasappa, R. Prasad, C. Srinivas, D. Rao, M. B. Thippeswamy, H. | Indian J Psychiatry | 2024 |
Craniopharyngioma |
| Correlation analysis between plasma biomarkers albumin, fibrinogen, and their ratio with postoperative delirium in patients undergoing non-cardiac surgery: a systematic review and meta-analysis | Lu, Z. Wang, B. Liu, M. Yu, D. Li, J. | Am J Transl Res | 2024 |
Albumin |
| Risk factors for hypoactive delirium in patients with nontraumatic ARDS: a prospective observational study | Lian, F. Li, F. Tang, X. Yuan, Y. | Sci Rep | 2024 |
Humans |
| Current Practices and Attitudes of Cardiac Nurses Regarding Cognitive Screening in Patients With Acute Coronary Syndrome | Zhao, E. Lowres, N. Bloomfield, J. Weddell, J. Tofler, G. Gallagher, R. | Heart Lung Circ | 2024 |
Acute coronary syndrome |
| Related factors of delirium after transsphenoidal endoscopic pituitary adenoma resection-A matched retrospective cohort study | Zhang, S. Chen, Y. Wang, X. Liu, J. Chen, Y. Zhang, G. | J Clin Neurosci | 2024 |
Neuroendoscopy |
| Prevalence of post-stroke delirium in acute settings: A systematic review and meta-analysis | Ye, F. Ho, M. H. Lee, J. J. | Int J Nurs Stud | 2024 |
Acute setting |
| Predictive factors for postoperative delirium in thoracic surgery | Yaguchi, T. Ichinokawa, H. Kirino, E. Suzuki, M. Komori, K. Matsunaga, T. Takamochi, K. Suzuki, K. | Gen Thorac Cardiovasc Surg | 2024 |
Postoperative delirium |
| Preoperative cognitive impairment and postoperative delirium among Holocaust survivors who achieved longevity | Weiss, Y. Zarour, S. Kiselevich, Y. Abu Ghanim, M. Hikry, D. Sinai Brzezinski, I. Zac, L. Cohen, B. Matot, I. | J Am Geriatr Soc | 2024 |
Holocaust |
| Substance use problems and disorders among adults 50 years and older receiving mental health treatment for a primary neurocognitive disorder | Ware, O. D. Baik, S. Becker, T. D. Neukrug, H. Zimmerman, S. | Aging Ment Health |
Aging |
|
| The risk of delirium after sedation with propofol or midazolam in intensive care unit patients | van Gelder, T. G. van Diem-Zaal, I. J. Dijkstra-Kersten, S. M. A. de Mul, N. Lalmohamed, A. Slooter, A. J. C. | Br J Clin Pharmacol | 2024 |
critical care |