What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Pharmacological interventions for the treatment of delirium in critically ill adults
- Authors
- Burry, L. Hutton, B. Williamson, D. R. Mehta, S. Adhikari, N. K. Cheng, W. Ely, E. W. Egerod, I. Fergusson, D. A. Rose, L.
- Year
- 2019
- Journal
- Cochrane Database Syst Rev
- Abstract
BACKGROUND: Although delirium is typically an acute reversible cognitive impairment, its presence is associated with devastating impact on both short-term and long-term outcomes for critically ill patients. Advances in our understanding of the negative impact of delirium on patient outcomes have prompted trials evaluating multiple pharmacological interventions. However, considerable uncertainty surrounds the relative benefits and safety of available pharmacological interventions for this population. OBJECTIVES: Primary objective1. To assess the effects of pharmacological interventions for treatment of delirium on duration of delirium in critically ill adults with confirmed or documented high risk of deliriumSecondary objectivesTo assess the following:1. effects of pharmacological interventions on delirium-free and coma-free days; days with coma; delirium relapse; duration of mechanical ventilation; intensive care unit (ICU) and hospital length of stay; mortality; and long-term outcomes (e.g. cognitive; discharge disposition; health-related quality of life); and2. the safety of such treatments for critically ill adult patients. SEARCH METHODS: We searched the following databases from their inception date to 21 March 2019: Ovid MEDLINE(R), Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Embase Classic+Embase, and PsycINFO using the Ovid platform. We also searched the Cochrane Library on Wiley, the International Prospective Register of Systematic Reviews (PROSPERO) (http://www.crd.york.ac.uk/PROSPERO/), the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. We performed a grey literature search of relevant databases and websites using the resources listed in Grey Matters developed by the Canadian Agency for Drugs and Technologies in Health (CADTH). We also searched trial registries and abstracts from annual scientific critical care and delirium society meetings. SELECTION CRITERIA: We sought randomized controlled trials (RCTs), including quasi-RCTs, of any pharmacological (drug) for treatment of delirium in critically ill adults. The drug intervention was to be compared to another active drug treatment, placebo, or a non-pharmacological intervention (e.g. mobilization). We did not apply any restrictions in terms of drug class, dose, route of administration, or duration of delirium or drug exposure. We defined critically ill patients as those treated in an ICU of any specialty (e.g. burn, cardiac, medical, surgical, trauma) or high-dependency unit. DATA COLLECTION AND ANALYSIS: Two review authors independently identified studies from the search results; four review authors (in pairs) performed data extraction and assessed risk of bias independently. We performed data synthesis through pairwise meta-analysis and network meta-analysis (NMA). Our hypothetical network structure was designed to be analysed at the drug class level and illustrated a network diagram of ‘nodes’ (i.e. drug classes) and ‘edges’ (i.e. comparisons between different drug classes from existing trials), thus describing a treatment network of all possible comparisons between drug classes. We assessed the quality of the body of evidence according to GRADE, as very low, low, moderate, or high. MAIN RESULTS: We screened 7674 citations, from which 14 trials with 1844 participants met our inclusion criteria. Ten RCTs were placebo-controlled, and four reported comparisons of different drugs. Drugs examined in these trials were the following: antipsychotics (n = 10), alpha2 agonists (n = 3; all dexmedetomidine), statins (n = 2), opioids (n = 1; morphine), serotonin antagonists (n = 1; ondansetron), and cholinesterase (CHE) inhibitors (n = 1; rivastigmine). Only one of these trials consistently used non-pharmacological interventions that are known to improve patient outcomes in both intervention and control groups.Eleven studies (n = 1153 participants) contributed to analysis of the primary outcome. Results of the NMA showed that the intervention with the smallest ratio of means (RoM) (i.e. most preferred) compared with placebo was the alpha2 agonist dexmedetomidine (0.58; 95% credible interval (CrI) 0.26 to 1.27; surface under the cumulative ranking curve (SUCRA) 0.895; moderate-quality evidence). In order of descending SUCRA values (best to worst), the next best interventions were atypical antipsychotics (RoM 0.80, 95% CrI 0.50 to 1.11; SUCRA 0.738; moderate-quality evidence), opioids (RoM 0.88, 95% CrI 0.37 to 2.01; SUCRA 0.578; very-low quality evidence), and typical antipsychotics (RoM 0.96, 95% CrI 0.64 to1.36; SUCRA 0.468; high-quality evidence).The NMAs of multiple secondary outcomes revealed that only the alpha2 agonist dexmedetomidine was associated with a shorter duration of mechanical ventilation (RoM 0.55, 95% CrI 0.34 to 0.89; moderate-quality evidence), and the CHE inhibitor rivastigmine was associated with a longer ICU stay (RoM 2.19, 95% CrI 1.47 to 3.27; moderate-quality evidence). Adverse events often were not reported in these trials or, when reported, were rare; pair-wise analysis of QTc prolongation in seven studies did not show significant differences between antipsychotics, ondansetron, dexmedetomidine, and placebo. AUTHORS’ CONCLUSIONS: We identified trials of varying quality that examined six different drug classes for treatment of delirium in critically ill adults. We found evidence that the alpha2 agonist dexmedetomidine may shorten delirium duration, although this small effect (compared with placebo) was seen in pairwise analyses based on a single study and was not seen in the NMA results. Alpha2 agonists also ranked best for duration of mechanical ventilation and length of ICU stay, whereas the CHE inhibitor rivastigmine was associated with longer ICU stay. We found no evidence of a difference between placebo and any drug in terms of delirium-free and coma-free days, days with coma, physical restraint use, length of stay, long-term cognitive outcomes, or mortality. No studies reported delirium relapse, resolution of symptoms, or quality of life. The ten ongoing studies and the six studies awaiting classification that we identified, once published and assessed, may alter the conclusions of the review.
- PMID
- Keywords
- Page(s)
- Volume
- 9
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Military Service Members and Emergence Delirium Screening: An Evidence-Based Practice Project. | Wheat, L. L., 2nd Turner, B. S. Diaz, A. Maani, C. V. | J Perianesth Nurs | 2018 |
emergence delirium |
| Can delirium research activity impact on routine delirium recognition? A prospective cohort study. | Welch, C. Jackson, T. A. | BMJ Open | 2018 |
dementia |
| Preoperative STOP-BANG Scores and Postoperative Delirium and Coma in Thoracic Surgery Patients. | Wang, S. Sigua, N. L. Manchanda, S. Gradney, S. Khan, S. H. Perkins, A. Kesler, K. Khan, B. | Ann Thorac Surg | 2018 | |
| The Cost of ICU Delirium and Coma in the Intensive Care Unit Patient. | Vasilevskis, E. E. Chandrasekhar, R. Holtze, C. H. Graves, J. Speroff, T. Girard, T. D. Patel, M. B. Hughes, C. G. Cao, A. Pandharipande, P. P. Ely, E. W. | Med Care | 2018 | |
| Pharmacologic prevention of postoperative delirium after on-pump cardiac surgery: A meta-analysis of randomized trials. | Tao, R. Wang, X. W. Pang, L. J. Cheng, J. Wang, Y. M. Gao, G. Q. Liu, Y. Wang, C. | Medicine | 2018 |
Antipsychotic Agents/*therapeutic use |
| Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging. | Shinozaki, G. Braun, P. R. Hing, B. W. Q. Ratanatharathorn, A. Klisares, M. J. Duncan, G. N. Jellison, S. S. Heinzman, J. T. Nagahama, Y. Close, L. Sabbagh, S. Dlouhy, B. J. Howard, M. A. Kawasaki, H. Cho, H. R. | Front Aging Neurosci | 2018 |
DNA methylation |
| The Hospital Elder Life Program: Past and Future. | Scheunemann, L. P. Girard, T. D. Skidmore, E. R. Resnick, N. M. | Am J Geriatr Psychiatry | 2018 | |
| Delirium in the Acute Phase of Ischemic Stroke: Incidence, Risk Factors, and Effects on Functional Outcome. | Qu, J. Chen, Y. Luo, G. Zhong, H. Xiao, W. Yin, H. | J Stroke Cerebrovasc Dis | 2018 |
Activities of Daily Living |
| Effect of dynamic light at the coronary care unit on the length of hospital stay and development of delirium: A retrospective cohort study. | Pustjens, T. Schoutens, A. M. C. Janssen, L. Heesen, W. F. | Journal of Geriatric Cardiology | 2018 |
neuroleptic agent |
| Frailty and Delirium in Older Adults: A Systematic Review and Meta-Analysis of the Literature. | Persico, I. Cesari, M. Morandi, A. Haas, J. Mazzola, P. Zambon, A. Annoni, G. Bellelli, G. | J Am Geriatr Soc | 2018 |
cognition |
| Medications and Patient Characteristics Associated With Falling in the Hospital. | OʼNeil, C. A. Krauss, M. J. Bettale, J. Kessels, A. Costantinou, E. Dunagan, W. C. Fraser, V. J. | Journal of Patient Safety | 2018 |
adult |
| Delirium detection using relative delta power based on 1-minute single-channel EEG: a multicentre study. | Numan, T. van den Boogaard, M. Kamper, A. M. Rood, P. J. T. Peelen, L. M. Slooter, A. J. C. | Br J Anaesth | 2018 |
complications, postoperative |
| Low skeletal muscle mass as a risk factor for postoperative delirium in elderly patients undergoing colorectal cancer surgery. | Mosk, C. A. L. A. van Vugt J de Jonge, H. Witjes, C. D. Buettner, S. Ijzermans, J. N. van der Laan, L. | Clin Interv Aging | 2018 |
Aged |
| Symptom expression in advanced cancer patients admitted to hospice or home care with and without delirium. | Mercadante, S. Masedu, F. Maltoni, M. De Giovanni, D. Montanari, L. Pittureri, C. Berte, R. Russo, D. Ursini, L. Marinangeli, F. Aielli, F. | Intern Emerg Med | 2018 |
Advanced cancer |
| Symptom Expression in Patients with Advanced Cancer Admitted to an Acute Supportive/Palliative Care Unit With and Without Delirium. | Mercadante, S. Adile, C. Ferrera, P. Cortegiani, A. Casuccio, A. | Oncologist | 2018 |
Advanced cancer |
| Pain, agitation and delirium assessment and management in a community medical-surgical ICU: results from a prospective observational study and nurse survey. | Maximous, R. Miller, F. Tan, C. Camargo, M. Ross, K. Marshall, C. Yung, P. Fleming, D. Law, M. Tsang, J. L. Y. | BMJ Open Qual | 2018 |
attitudes |
| Evaluating the risk profile of quetiapine in treating delirium in the intensive care adult population: A retrospective review. | Mangan, K. C. McKinzie, B. P. Deloney, L. P. Leon, S. M. Eriksson, E. A. | J Crit Care | 2018 |
Delirium |
| Cerebral monitoring of anaesthesia on reducing cognitive dysfunction and postoperative delirium: a systematic review. | Luo, C. Zou, W. | J Int Med Res | 2018 |
Anesthesia/*adverse effects/methods |
| Dysfunctional cerebral autoregulation is associated with delirium in critically ill adults. | Lee, K. F. Wood, M. D. Maslove, D. M. Muscedere, J. G. Boyd, J. G. | J Cereb Blood Flow Metab | 2018 |
Cerebral autoregulation |
| Defining delirium in idiopathic Parkinson's disease: A systematic review. | Lawson, R. A. McDonald, C. Burn, D. J. | Parkinsonism and Related Disorders | 2018 |
adult |
| Delirium assessment in neuro-critically ill patients: A validation study. | Larsen, L. K. Frokjaer, V. G. Nielsen, J. S. Skrobik, Y. Winkler, Y. Moller, K. Petersen, M. Egerod, I. | Acta Anaesthesiol Scand | 2018 |
acute brain injury |
| Benzodiazepine Use and Neuropsychiatric Outcomes in the ICU: A Systematic Review | Kok, L. Slooter, A. J. Hillegers, M. H. van Dijk, D. Veldhuijzen, D. S. | Crit Care Med | 2018 | |
| Hospital Elder Life Program: Systematic Review and Meta-analysis of Effectiveness | Hshieh, T. T. Yang, T. Gartaganis, S. L. Yue, J. Inouye, S. K. | Am J Geriatr Psychiatry | 2018 |
Delirium prevention |
| Predictive Modeling for Geriatric Hip Fracture Patients: Early Surgery and Delirium Have the Largest Influence on Length of Stay. | Hecht, G. Slee, C. A. Goodell, P. B. Taylor, S. L. Wolinsky, P. R. | J Am Acad Orthop Surg | 2018 | |
| The Erasmus Frailty Score is associated with delirium and 1-year mortality after Transcatheter Aortic Valve Implantation in older patients. The TAVI Care & Cure program. | Goudzwaard, J. A. de Ronde-Tillmans, Mjag El Faquir, N. Acar, F. Van Mieghem, N. M. Lenzen, M. J. de Jaegere, P. P. T. Mattace-Raso, F. U. S. | Int J Cardiol | 2019 |
Delirium |
| Transcutaneous electrical acupoint stimulation for prevention of postoperative delirium in geriatric patients with silent lacunar infarction: a preliminary study. | Gao, F. Zhang, Q. Li, Y. Tai, Y. Xin, X. Wang, X. Wang, Q. | Clin Interv Aging | 2018 |
*Acupuncture Points |
| Dexmedetomidine in prevention and treatment of postoperative and intensive care unit delirium: a systematic review and meta-analysis. | Flükiger, J. Hollinger, A. Speich, B. Meier, V. Tontsch, J. Zehnder, T. Siegemund, M. | Annals of Intensive Care | 2018 |
dexmedetomidine |
| Long-term prognostic value of delirium in elderly patients with acute cardiac diseases admitted to two cardiac intensive care units: a prospective study (DELIRIUM CORDIS). | Falsini, G. Grotti, S. Porto, I. Toccafondi, G. Fraticelli, A. Angioli, P. Ducci, K. Liistro, F. Pieroni, M. Taddei, T. Romanelli, S. Rossi, R. Bolognese, L. | Eur Heart J Acute Cardiovasc Care | 2018 |
Acute Disease |
| Persistent Delirium in Elderly patients Three Months After Hospital Discharge from a University Clinic. | Constaín, G. A. Ocampo Saldarriaga, M. V. Velásquez Tirado, J. D. Rodríguez-Gázquez, M. D. L. Á Betancur Morales, L. M. Rico Escobar, J. J. Castilla Agudelo, G. A. Maya Osorno, A. F. | Revista Colombiana de Psiquiatria | 2018 |
aged |
| A Web-Based Serious Game on Delirium as an Educational Intervention for Medical Students: Randomized Controlled Trial. | Buijs-Spanjers, K. R. Hegge, H. H. Jansen, C. J. Hoogendoorn, E. de Rooij, S. E. | JMIR Serious Games | 2018 |
delirium |
| Relationship Between Near-Infrared Spectroscopy-Derived Cerebral Oxygenation and Delirium in Critically Ill Patients: A Systematic Review. | Bendahan, N. Neal, O. Ross-White, A. Muscedere, J. Boyd, J. G. | J Intensive Care Med | 2018 |
Cam-icu |
| Ability of suvorexant to prevent delirium in patients in the intensive care unit: a randomized controlled trial. | Azuma, K. Takaesu, Y. Soeda, H. Iguchi, A. Uchida, K. Ohta, S. Mishima, S. Inoue, T. Inoue, Y. Oda, J. | Acute Med Surg | 2018 |
Delirium |
| Incidence of postoperative delirium in elderly ambulatory patients: A prospective evaluation using the FAM-CAM instrument. | Aya, A. G. M. Pouchain, P. H. Thomas, H. Ripart, J. Cuvillon, P. | J Clin Anesth | 2018 |
Ambulatory surgery |
| Potential Role of Exogenous Melatonin Supplement in Delirium Prevention in Critically Ill Patients: A Double-Blind Randomized Pilot Study. | Abbasi, S. Farsaei, S. Ghasemi, D. Mansourian, M. | Iran J Pharm Res | 2018 |
Clinical trial |
| Predictive nomogram for postoperative delirium in elderly patients with a hip fracture. | Zhang, X. Tong, D. K. Ji, F. Duan, X. Z. Liu, P. Z. Qin, S. Xu, K. H. Di-li, X. T. | Injury | 2018 |
aged |
| Advances in dementia with Lewy bodies | Armstrong, M. J. | Ther Adv Neurol Disord | 2021 |
Lewy body dementia |
| Factors Influencing CAM-ICU Documentation and Inappropriate "Unable to Assess" Responses | Awan, O. M. Buhr, R. G. Kamdar, B. B. | Am J Crit Care | 2021 |
Aged, 80 and over |
| Prediction of Postictal Delirium Following Status Epilepticus in the ICU: First Insights of an Observational Cohort Study | Baumann, S. M. Semmlack, S. Hunziker, S. Kaplan, P. W. De Marchis, G. M. Rüegg, S. Marsch, S. Sutter, R. | Crit Care Med | 2021 |
Aged |
| Dementia as a predictor of morbidity and mortality in patients with delirium. | van Roessel, S. Keijsers, C. J. P. W. Romijn, M. D. M. | Maturitas | 2019 |
advance care planning |
| Factors Associated With Delirium Following Electroconvulsive Therapy: A Systematic Review. | Tsujii, T. Uchida, T. Suzuki, T. Mimura, M. Hirano, J. Uchida, H. | J Ect | 2019 | |
| Predictors of delirium after cardiac surgery in patients with sleep-disordered breathing. | Tafelmeier, M. Knapp, M. Lebek, S. Floerchinger, B. Camboni, D. Creutzenberg, M. Wittmann, S. Zeman, F. Schmid, C. Maier, L. S. Wagner, S. Arzt, M. | Eur Respir J | 2019 | |
| The trajectory of C-reactive protein serum levels in older hip fracture patients with postoperative delirium. | Slor, C. J. Witlox, J. Adamis, D. Jansen, Rwmm Houdijk, A. P. J. van Gool, W. A. de Jonghe, J. F. M. Eikelenboom, P. | Int J Geriatr Psychiatry | 2019 |
C-reactive protein |
| Risk Factors for Postoperative Delirium in Type A Aortic Dissection Patients: A Retrospective Study. | Shi, Q. Mu, X. Zhang, C. Wang, S. Hong, L. Chen, X. | Med Sci Monit | 2019 | |
| Cortical and subcortical changes in resting-state functional connectivity before and during an episode of postoperative delirium. | Oh, J. Shin, J. E. Yang, K. H. Kyeong, S. Lee, W. S. Chung, T. S. Kim, J. J. | Aust N Z J Pschiatry | 2019 |
Postoperative delirium |
| Association of COMT Val(158)Met Polymorphism With Delirium Risk and Outcomes After Traumatic Brain Injury. | Nekrosius, D. Kaminskaite, M. Jokubka, R. Pranckeviciene, A. Lideikis, K. Tamasauskas, A. Bunevicius, A. | J Neuropsychiatry Clin Neurosci | 2019 |
Delirium |
| Association of earlier extubation and postoperative delirium after coronary artery bypass grafting. | Muller Moran, H. R. Maguire, D. Maguire, D. Kowalski, S. Jacobsohn, E. Mackenzie, S. Grocott, H. Arora, R. C. | Journal of Thoracic and Cardiovascular Surgery | 2019 |
adult |
| Delirium, Dementia, and In-Hospital Mortality: The Results From the Italian Delirium Day 2016, A National Multicenter Study. | Morandi, A. Di Santo, S. G. Zambon, A. Mazzone, A. Cherubini, A. Mossello, E. Bo, M. Marengoni, A. Bianchetti, A. Cappa, S. Fimognari, F. Antonelli Incalzi, R. Gareri, P. Perticone, F. Campanini, M. Penco, I. Montorsi, M. Di Bari, M. Trabucchi, M. Bellell | J Gerontol A Biol Sci Med Sci | 2019 |
Acute hospital |
| Type D personality is a predictor of prolonged acute brain dysfunction (delirium/coma) after cardiovascular surgery. | Matsuishi, Y. Shimojo, N. Unoki, T. Sakuramoto, H. Tokunaga, C. Yoshino, Y. Hoshino, H. Ouchi, A. Kawano, S. Sakamoto, H. Hiramatsu, Y. Inoue, Y. | BMC Psychol | 2019 |
Aged |
| Delirium after primary percutaneous coronary intervention in aged individuals with acute ST-segment elevation myocardial infarction: A retrospective study. | Li, S. Zhang, X. H. Zhou, G. D. Wang, J. F. | Exp Ther Med | 2019 |
ST-segment elevation |
| Preventing Delirium Takes a Village: Systematic Review and Meta-Analysis of Delirium Preventive Models of Care. | Khan, A. Boukrina, O. Oh-Park, M. Flanagan, N. A. Singh, M. Oldham, M. | J Hosp Med | 2019 | |
| Clinical predictors of postoperative delirium, functional status, and mortality in geriatric patients undergoing non-elective surgery for hip fracture. | Harris, M. J. Brovman, E. Y. Urman, R. D. | J Clin Anesth | 2019 |
Delirium |
| Impairments in balance and mobility identify delirium in patients with comorbid dementia. | Gual, N. Richardson, S. J. Davis, D. H. J. Bellelli, G. Hasemann, W. Meagher, D. Kreisel, S. H. MacLullich, A. M. J. Cerejeira, J. Inzitari, M. Morandi, A. | Int Psychogeriatr | 2019 |
Delirium |
| Delirium motor subtypes and prognosis in hospitalized geriatric patients - A prospective observational study. | Evensen, S. Saltvedt, I. Lydersen, S. Wyller, T. B. Taraldsen, K. Sletvold, O. | J Psychosom Res | 2019 |
Dmss |
| Delirium risk in non-surgical patients: systematic review of predictive tools. | Dylan, F. Byrne, G. Mudge, A. M. | Arch Gerontol Geriatr | 2019 |
clinical prediction rule |
| Pain, Opioid Intake, and Delirium Symptoms in Adults Following Joint Replacement Surgery. | Denny, D. L. Lindseth, G. N. | West J Nurs Res | 2019 |
joint replacement surgery |
| Addition of Vitamin B Complex to Prime Solution in Cobalamin-Deficient Patients to Prevent Postoperative Delirium. | Demirdas, E. Atilgan, K. | The Heart Surgery Forum | 2019 |
vitamin B complex |
| Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence | Daiello, L. A. Racine, A. M. Yun Gou, R. Marcantonio, E. R. Xie, Z. Kunze, L. J. Vlassakov, K. V. Inouye, S. K. Jones, R. N. Alsop, D. Travison, T. Arnold, S. Cooper, Z. Dickerson, B. Fong, T. Metzger, E. Pascual-Leone, A. Schmitt, E. M. Shafi, M. Cavalla | Anesthesiology | 2019 | |
| CSF Beta-amyloid 1-42 Concentration Predicts Delirium Following Elective Arthroplasty Surgery in an Observational Cohort Study. | Cunningham, E. L. McGuinness, B. McAuley, D. F. Toombs, J. Mawhinney, T. O'Brien, S. Beverland, D. Schott, J. M. Lunn, M. P. Zetterberg, H. Passmore, A. P. | Ann Surg | 2018 |
adverse outcome |
| Three Nurse-administered Protocols Reduce Nutritional Decline and Frailty in Older Gastrointestinal Surgery Patients: A Cluster Randomized Trial. | Chia-Hui Chen, C. Yang, Y. T. Lai, I. R. Lin, B. R. Yang, C. Y. Huang, J. Tien, Y. W. Chen, C. N. Lin, M. T. Liang, J. T. Li, H. C. Huang, G. H. Inouye, S. K. | J Am Med Dir Assoc | 2019 |
Frailty |
| Moderate hypercapnia may not contribute to postoperative delirium in patients undergoing bronchoscopic intervention. | Cheng, Q. Li, L. Yang, M. Sun, L. Li, R. Huang, R. Ma, J. | Medicine | 2019 |
Age Factors |
| Evaluation of a method to estimate the point prevalence of cognitive impairment and delirium in a multi-campus Australian health service. | Casey, P. Darzins, P. Webb-St Mart, M. Baldwin, C. Riddell, K. Johnson, C. Cross, W. | Australas J Ageing | 2019 |
adult |
| Effect of Targeting Mean Arterial Pressure During Cardiopulmonary Bypass by Monitoring Cerebral Autoregulation on Postsurgical Delirium Among Older Patients: A Nested Randomized Clinical Trial. | Brown, C. H. th Neufeld, K. J. Tian, J. Probert, J. LaFlam, A. Max, L. Hori, D. Nomura, Y. Mandal, K. Brady, K. Hogue, C. W. Shah, A. Zehr, K. Cameron, D. Conte, J. Bienvenu, O. J. Gottesman, R. Yamaguchi, A. Kraut, M. | JAMA Surg | 2019 | |
| A Comparison of Resource Utilization in the Management of Anticholinergic Delirium Between Physostigmine and Nonantidote Therapy. | Boley, S. P. Stellpflug, S. J. | Annals of Pharmacotherapy | 2019 |
adult |
| Do health care professionals worry about delirium? Relatives' experience of delirium in the intensive care unit: A qualitative interview study. | Bohart, S. Merete Moller, A. Forsyth Herling, S. | Intensive Crit Care Nurs | 2019 |
Delirium |
| The association of indwelling urinary catheter with delirium in hospitalized patients and nursing home residents: an explorative analysis from the “Delirium Day 2015”. | Bo, M. Porrino, P. Di Santo, S. G. Mazzone, A. Cherubini, A. Mossello, E. Bianchetti, A. Musicco, M. Ferrari, A. Ferrara, N. Filippini, C. Trabucchi, M. Morandi, A. Bellelli, G. | Aging Clinical and Experimental Research | 2019 |
indwelling urinary catheter |
| Assessment of analgesia, sedation, physical restraint and delirium in patients admitted to Spanish intensive care units. Proyecto ASCyD. | Arias-Rivera, S. López-López, C. Frade-Mera, M. J. Via-Clavero, G. Rodríguez-Mondéjar, J. J. Sánchez-Sánchez, M. M. Acevedo-Nuevo, M. Gil-Castillejos, D. Robleda, G. Cachón-Pérez, M. Latorre-Marco, I. | Enfermeria intensiva | 2019 |
NCT03773874 |
| Influence of early elective tracheostomy on the incidence of postoperative complications in patients undergoing head and neck surgery. | Meier, J. Wunschel, M. Angermann, A. Ettl, T. Metterlein, T. Klingelhöffer, C. Reichert, T. E. Ritzka, M. | BMC Anesthesiology | 2019 |
endotracheal tube |
| Pharmacological Prevention of Postoperative Delirium: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. | Liu, Y. Li, X. J. Liang, Y. Kang, Y. | Evidence-Based Complementary and Alternative Medicine | 2019 |
cyproheptadine |
| Delirium: Medical Students’ Knowledge and Effectiveness of Different Teaching Methods. | Baessler, F. Ciprianidis, A. Rizvi, A. Z. Weidlich, J. Wagner, F. L. Klein, S. B. Baumann, T. C. Nikendei, C. Schultz, J. H. | Am J Geriatr Psychiatry | 2019 |
adult |
| Low Plasma Cholinesterase Activity is Associated With Postoperative Delirium After Noncardiac Surgery in Elderly Patients: AProspective Observational Study. | Zhao, B. Ni, Y. Tian, X. | Psychosomatics | 2019 |
acetylcholinesterase |
| Interventions for preventing delirium in older people in institutional long-term care. | Clegg A, Siddiqi N, Heaven A, Young J, Holt R | The Cochrane database of systematic reviews | 2014 |
Aged, Delirium, chemically induced, Fluid Therapy, Frail Elderly, Humans, Institutionalization, Long-Term Care, Medication Reconciliation, Randomized Controlled Trials as Topic |
| Effect of flurbiprofen axetil on postoperative delirium for elderly patients. | Wang, X. Wang, Y. Hu, Y. Wang, L. Zhao, W. Wei, L. Chen, H. Han, F. | Brain Behav | 2019 |
elder |
| Clinical and prognostic implications of delirium in elderly patients with non–ST-segment elevation acute coronary syndromes. | Vives-Borrás, M. Martínez-Sellés, M. Ariza-Solé, A. Vidán, M. T. Formiga, F. Bueno, H. Sanchís, J. Alegre, O. Durán-Cambra, A. López-Palop, R. Abu-Assi, E. Sionis, A. | Journal of Geriatric Cardiology | 2019 |
aged |
| Brain network disintegration as a final common pathway for delirium: a systematic review and qualitative meta-analysis. | van Montfort, S. J. T. van Dellen, E. Stam, C. J. Ahmad, A. H. Mentink, L. J. Kraan, C. W. Zalesky, A. Slooter, A. J. C. | Neuroimage Clin | 2019 |
Aging |
| Predictive Factors of Postoperative Delirium in Patients After Pancreaticoduodenectomy. | Tomimaru, Y. Park, S. A. Shibata, A. Miyagawa, S. Noguchi, K. Noura, S. Imamura, H. Shirakawa, T. Dono, K. | J Gastrointest Surg | 2019 |
Delirium |
| Bach to the Basics: Implementation and Impact of a Postoperative, Inpatient Personalized Music Program for Older Adults. | Sharda, N. Mattoon, E. Matters, L. Prewitt, J. McDonald, S. Sloane, R. Cassas, C. White, H. | J Perianesth Nurs | 2019 |
delirium prevention |
| Screening for delirium after surgery: validation of the 4 A's test (4AT) in the post-anaesthesia care unit. | Saller, T. MacLullich, A. M. J. Schafer, S. T. Crispin, A. Neitzert, R. Schule, C. von Dossow, V. Hofmann-Kiefer, K. F. | Anaesthesia | 2019 |
delirium |
| Measuring the distress related to delirium in older surgical patients and their relatives. | Partridge, J. S. L. Crichton, S. Biswell, E. Harari, D. Martin, F. C. Dhesi, J. K. | Int J Geriatr Psychiatry | 2019 |
carer and relative distress |
| Functional Outcomes After Hip Fracture in Independent Community-Dwelling Patients. | Ouellet, J. A. Ouellet, G. M. Romegialli, A. M. Hirsch, M. Berardi, L. Ramsey, C. M. Cooney, L. M., Jr. Walke, L. M. | Journal of Hospital Medicine | 2019 |
adult |
| Clinical characteristics and prognosis for delirium in Spanish internal medicine departments: An analysis from a large clinical-administrative database. | Marco, J. Mendez, M. Cruz-Jentoft, A. J. Garcia Klepzig, J. L. Calvo, E. Canora, J. Zapatero, A. Barba, R. | Rev Clin Esp | 2019 |
Anciano |
| Reducing Delirium and Improving Patient Satisfaction With a Perioperative Mindfulness Intervention: A Mixed-Methods Pilot Study. | Lisann-Goldman, L. R. Pagnini, F. Deiner, S. G. Langer, E. J. | Holistic Nursing Practice | 2019 |
adult |
| Association between Inpatient Delirium and Hospital Readmission in Patients >/= 65 Years of Age: A Retrospective Cohort Study. | LaHue, S. C. Douglas, V. C. Kuo, T. Conell, C. A. Liu, V. X. Josephson, S. A. Angel, C. Brooks, K. B. | J Hosp Med | 2019 | |
| Feasibility and acceptability of family administration of delirium detection tools in the intensive care unit: a patient-oriented pilot study. | Krewulak, K. D. Sept, B. G. Stelfox, H. T. Ely, E. W. Davidson, J. E. Ismail, Z. Fiest, K. M. | CMAJ Open | 2019 | |
| Diabetes and elevated preoperative hba1c level as risk factors for postoperative delirium after cardiac surgery: An observational cohort study. | Kotfis, K. Szylińska, A. Listewnik, M. Brykczyński, M. Ely, E. W. Rotter, I. | Neuropsychiatric Disease and Treatment | 2019 |
creatinine |
| Evaluation of Changes in Functional Status in the Year after Aortic Valve Replacement. | Kim, D. H. Afilalo, J. Shi, S. M. Popma, J. J. Khabbaz, K. R. Laham, R. J. Grodstein, F. Guibone, K. Lux, E. Lipsitz, L. A. | JAMA Intern Med | 2019 |
aged |
| Association of electroencephalogram trajectories during emergence from anaesthesia with delirium in the postanaesthesia care unit: an early sign of postoperative complications. | Hesse, S. Kreuzer, M. Hight, D. Gaskell, A. Devari, P. Singh, D. Taylor, N. B. Whalin, M. K. Lee, S. Sleigh, J. W. García, P. S. | British Journal of Anaesthesia | 2019 |
fentanyl |
| Evaluation of a Multidisciplinary Pain, Agitation, and Delirium Guideline in Mechanically Ventilated Critically Ill Adults. | Heim, M. Draheim, R. Krupp, A. Breihan, P. O'Rourke, A. Wells, J. Fish, J. | Hosp Pharm | 2019 |
analgesics |
| Risk factors for postoperative delirium in patients undergoing microvascular decompression. | He, Z. Cheng, H. Wu, H. Sun, G. Yuan, J. | PLoS One | 2019 | |
| Preliminary investigation of predictors of distress in informal caregivers of patients with delirium superimposed on dementia. | Grossi, E. Lucchi, E. Gentile, S. Trabucchi, M. Bellelli, G. Morandi, A. | Aging Clin Exp Res | 2019 |
Delirium superimposed on dementia |
| Use of the confusion assessment method in multicentre delirium trials: training and standardisation. | Green, J. R. Smith, J. Teale, E. Collinson, M. Avidan, M. S. Schmitt, E. M. Inouye, S. K. Young, J. | BMC Geriatr | 2019 |
Confusion assessment method |
| Distinguishing characteristics of delirium in a skilled nursing facility in Spain: Influence of baseline cognitive status. | Franco, J. G. Trzepacz, P. T. Gaviria, A. M. Sepulveda, E. Vinuelas, E. Palma, J. Grau, I. Vilella, E. | Int J Geriatr Psychiatry | 2019 |
Delirium |
| Modifiable Risk Factors for Delirium in Critically Ill Trauma Patients: A Multicenter Prospective Study. | Duceppe, M. A. Williamson, D. R. Elliott, A. Para, M. Poirier, M. C. Delisle, M. S. Deckelbaum, D. Razek, T. Desjardins, M. Bertrand, J. C. Bernard, F. Rico, P. Burry, L. Frenette, A. J. Perreault, M. | J Intensive Care Med | 2019 |
delirium |
| Delirium after hip hemiarthroplasty for proximal femoral fractures in elderly patients: Risk factors and clinical outcomes. | de Jong, L. van Rijckevorsel, V. A. J. I. M. Raats, J. W. Klem, T. M. A. L. Kuijper, T. M. Roukema, G. R. | Clinical Interventions in Aging | 2019 |
hip prosthesis |
| Frailty Identification and Care Pathway: An Interdisciplinary Approach to Care for Older Trauma Patients. | Bryant, E. A. Tulebaev, S. Castillo-Angeles, M. Moberg, E. Senglaub, S. S. O'Mara, L. McDonald, M. Salim, A. Cooper, Z. | J Am Coll Surg | 2019 | |
| Validation of the O3DY French Version (O3DY-F) for the Screening of Cognitive Impairment in Community Seniors in the Emergency Department. | Bedard, C. Boucher, V. Voyer, P. Yadav, K. Eagles, D. Nadeau, A. Carmichael, P. H. Pelletier, M. Gouin, E. Berthelot, S. Daoust, R. Lague, A. Gagne, A. J. Emond, M. | J Emerg Med | 2019 |
cognitive impairment |
| Identification of delirium and subsyndromal delirium in intensive care patients. | Bastos, A. S. Beccaria, L. M. Silva, D. C. D. Barbosa, T. P. | Rev Bras Enferm | 2019 | |
| Off-label use of antipsychotics and associated factors in community living older adults. | Bakouni, H. Berbiche, D. Vasiliadis, H. M. | Aging Ment Health | 2019 |
age |
| Assessment of analgesia, sedation, physical restraint and delirium in patients admitted to Spanish intensive care units. Proyecto ASCyD | Arias-Rivera, S. Lopez-Lopez, C. Frade-Mera, M. J. Via-Clavero, G. Rodriguez-Mondejar, J. J. Sanchez-Sanchez, M. M. Acevedo-Nuevo, M. Gil-Castillejos, D. Robleda, G. Cachon-Perez, M. Latorre-Marco, I. | Enferm Intensiva | 2019 |
Contenciones mecanicas |
| Medication and medical diagnosis as risk factors for falls in older hospitalized patients. | Wedmann, F. Himmel, W. Nau, R. | Eur J Clin Pharmacol | 2019 |
Accidental falls |
| The inclusion of delirium in version 2 of the National Early Warning Score will substantially increase the alerts for escalating levels of care: findings from a retrospective database study of emergency medical admissions in two hospitals. | Mohammed, M. A. Faisal, M. Richardson, D. Scally, A. Howes, R. Beatson, K. Irwin, S. Speed, K. | Clin Med (London) | 2019 |
News2 |