Delirium Bibliography

Reference Information

Title

Introducing a machine learning algorithm for delirium prediction-the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead)

Authors

Benovic, S. Ajlani, A. H. Leinert, C. Fotteler, M. Wolf, D. Steger, F. Kestler, H. Dallmeier, D. Denkinger, M. Eschweiler, G. W. Thomas, C. Kocar, T. D.

Year

2024

Journal

Age Ageing

Abstract

INTRODUCTION: Post-operative delirium (POD) is a common complication in older patients, with an incidence of 14-56%. To implement preventative procedures, it is necessary to identify patients at risk for POD. In the present study, we aimed to develop a machine learning (ML) model for POD prediction in older patients, in close cooperation with the PAWEL (patient safety, cost-effectiveness and quality of life in elective surgery) project. METHODS: The model was trained on the PAWEL study’s dataset of 878 patients (no intervention, age ≥ 70, 209 with POD). Presence of POD was determined by the Confusion Assessment Method and a chart review. We selected 15 features based on domain knowledge, ethical considerations and a recursive feature elimination. A logistic regression and a linear support vector machine (SVM) were trained, and evaluated using receiver operator characteristics (ROC). RESULTS: The selected features were American Society of Anesthesiologists score, multimorbidity, cut-to-suture time, estimated glomerular filtration rate, polypharmacy, use of cardio-pulmonary bypass, the Montreal cognitive assessment subscores ‘memory’, ‘orientation’ and ‘verbal fluency’, pre-existing dementia, clinical frailty scale, age, recent falls, post-operative isolation and pre-operative benzodiazepines. The linear SVM performed best, with an ROC area under the curve of 0.82 [95% CI 0.78-0.85] in the training set, 0.81 [95% CI 0.71-0.88] in the test set and 0.76 [95% CI 0.71-0.79] in a cross-centre validation. CONCLUSION: We present a clinically useful and explainable ML model for POD prediction. The model will be deployed in the Supporting SURgery with GEriatric Co-Management and AI project.

PMID

PMID: 38776213

PMCID: PMC11110913

Keywords

Humans
Aged
Female
Male
*Machine Learning
*Delirium/diagnosis/epidemiology
Aged, 80 and over
*Geriatric Assessment/methods
Postoperative Complications/diagnosis/epidemiology/etiology
Risk Assessment
Risk Factors
Predictive Value of Tests
Age Factors
Support Vector Machine
Algorithms
delirium prediction
explainable artificial intelligence (AI)
machine learning
older people
post-operative delirium

Page(s)

Volume

Issue