What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients (Review)
- Authors
- Burton JK, Craig LE, Yong SQ, Siddiqi N, Teale EA, Woodhouse R, Barugh AJ, Shepherd AM, Brunton A, Freeman SC, Sutton AJ, Quinn TJ
- Year
- 2021
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is an acute neuropsychological disorder that is common in hospitalised patients. It can be distressing to patients and carers and it is associated with serious adverse outcomes. Treatment options for established delirium are limited and so prevention of delirium is desirable. Non-pharmacological interventions are thought to be important in delirium prevention. OBJECTIVES: To assess the effectiveness of non-pharmacological interventions designed to prevent delirium in hospitalised patients outside intensive care units (ICU).
Search methods: We searched ALOIS, the specialised register of the Cochrane Dementia and Cognitive Improvement Group, with additional searches conducted in MEDLINE, Embase, PsycINFO, CINAHL, LILACS, Web of Science Core Collection, ClinicalTrials.gov and the World Health Organization Portal/ICTRP to 16 September 2020. There were no language or date restrictions applied to the electronic searches, and no methodological filters were used to restrict the search.
Selection criteria: We included randomised controlled trials (RCTs) of single and multicomponent non-pharmacological interventions for preventing delirium in hospitalised adults cared for outside intensive care or high dependency settings. We only included non-pharmacological interventions which were designed and implemented to prevent delirium. DATA COLLECTION AND ANALYSIS: Two review authors independently examined titles and abstracts identified by the search for eligibility and extracted data from full-text articles. Any disagreements on eligibility and inclusion were resolved by consensus. We used standard Cochrane methodological procedures. The primary outcomes were: incidence of delirium; inpatient and later mortality; and new diagnosis of dementia. We included secondary and adverse outcomes as pre-specified in the review protocol. We used risk ratios (RRs) as measures of treatment effect for dichotomous outcomes and between-group mean differences for continuous outcomes. The certainty of the evidence was assessed using GRADE. A complementary exploratory analysis was undertaker using a Bayesian component network meta-analysis fixed-effect model to evaluate the comparative effectiveness of the individual components of multicomponent interventions and describe which components were most strongly associated with reducing the incidence of delirium.
Main results: We included 22 RCTs that recruited a total of 5718 adult participants. Fourteen trials compared a multicomponent delirium prevention intervention with usual care. Two trials compared liberal and restrictive blood transfusion thresholds. The remaining six trials each investigated a different non-pharmacological intervention. Incidence of delirium was reported in all studies. Using the Cochrane risk of bias tool, we identified risks of bias in all included trials. All were at high risk of performance bias as participants and personnel were not blinded to the interventions. Nine trials were at high risk of detection bias due to lack of blinding of outcome assessors and three more were at unclear risk in this domain. Pooled data showed that multi-component non-pharmacological interventions probably reduce the incidence of delirium compared to usual care (10.5% incidence in the intervention group, compared to 18.4% in the control group, risk ratio (RR) 0.57, 95% confidence interval (CI) 0.46 to 0.71, I2 = 39%; 14 studies; 3693 participants; moderate-certainty evidence, downgraded due to risk of bias). There may be little or no effect of multicomponent interventions on inpatient mortality compared to usual care (5.2% in the intervention group, compared to 4.5% in the control group, RR 1.17, 95% CI 0.79 to 1.74, I2 = 15%; 10 studies; 2640 participants; low-certainty evidence downgraded due to inconsistency and imprecision). No studies of multicomponent interventions reported data on new diagnoses of dementia. Multicomponent interventions may result in a small reduction of around a day in the duration of a delirium episode (mean difference (MD) -0.93, 95% CI -2.01 to 0.14 days, I2 = 65%; 351 participants; low-certainty evidence downgraded due to risk of bias and imprecision). The evidence is very uncertain about the effect of multicomponent interventions on delirium severity (standardised mean difference (SMD) -0.49, 95% CI -1.13 to 0.14, I2=64%; 147 participants; very low-certainty evidence downgraded due to risk of bias and serious imprecision). Multicomponent interventions may result in a reduction in hospital length of stay compared to usual care (MD -1.30 days, 95% CI -2.56 to -0.04 days, I2=91%; 3351 participants; low-certainty evidence downgraded due to risk of bias and inconsistency), but little to no difference in new care home admission at the time of hospital discharge (RR 0.77, 95% CI 0.55 to 1.07; 536 participants; low-certainty evidence downgraded due to risk of bias and imprecision). Reporting of other adverse outcomes was limited. Our exploratory component network meta-analysis found that re-orientation (including use of familiar objects), cognitive stimulation and sleep hygiene were associated with reduced risk of incident delirium. Attention to nutrition and hydration, oxygenation, medication review, assessment of mood and bowel and bladder care were probably associated with a reduction in incident delirium but estimates included the possibility of no benefit or harm. Reducing sensory deprivation, identification of infection, mobilisation and pain control all had summary estimates that suggested potential increases in delirium incidence, but the uncertainty in the estimates was substantial. Evidence from two trials suggests that use of a liberal transfusion threshold over a restrictive transfusion threshold probably results in little to no difference in incident delirium (RR 0.92, 95% CI 0.62 to 1.36; I2 = 9%; 294 participants; moderate-certainty evidence downgraded due to risk of bias). Six other interventions were examined, but evidence for each was limited to single studies and we identified no evidence of delirium prevention. AUTHORS’ CONCLUSIONS: There is moderate-certainty evidence regarding the benefit of multicomponent non-pharmacological interventions for the prevention of delirium in hospitalised adults, estimated to reduce incidence by 43% compared to usual care. We found no evidence of an effect on mortality. There is emerging evidence that these interventions may reduce hospital length of stay, with a trend towards reduced delirium duration, although the effect on delirium severity remains uncertain. Further research should focus on implementation and detailed analysis of the components of the interventions to support more effective, tailored practice recommendations.
- PMID
- Keywords
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Risk Factors for Postoperative Delirium After Gastrectomy in Gastric Cancer Patients. | Honda, S. Furukawa, K. Nishiwaki, N. Fujiya, K. Omori, H. Kaji, S. Makuuchi, R. Irino, T. Tanizawa, Y. Bando, E. Kawamura, T. Terashima, M. | World J Surg | 2018 | |
| Factors Associated with the Effectiveness of Intravenous Administration of Chlorpromazine for Delirium in Patients with Terminal Cancer. | Hasuo, H. Kanbara, K. Fujii, R. Uchitani, K. Sakuma, H. Fukunaga, M. | J Palliat Med | 2018 |
delirium |
| An evaluation of single question delirium screening tools in older emergency department patients. | Han, J. H. Wilson, A. Schnelle, J. F. Dittus, R. S. Wesley Ely, E. | American Journal of Emergency Medicine | 2018 |
adult |
| A contemporary population-based analysis of the incidence, cost, and outcomes of postoperative delirium following major urologic cancer surgeries. | Ha, A. Krasnow, R. E. Mossanen, M. Nagle, R. Hshieh, T. T. Rudolph, J. L. Chang, S. L. | Urol Oncol | 2018 |
Costs |
| Risk Factors and Outcomes of Delirium in Older Patients Admitted to Postacute Care with and without Dementia. | Gual, N. Morandi, A. Perez, L. M. Britez, L. Burbano, P. Man, F. Inzitari, M. | Dement Geriatr Cogn Disord | 2018 |
Crisis management |
| Frailty Assessment to Help Predict Patients at Risk of Delirium When Consulting the Emergency Department. | Giroux, M. Sirois, M. J. Boucher, V. Daoust, R. Gouin, E. Pelletier, M. Berthelot, S. Voyer, P. Emond, M. | J Emerg Med | 2018 |
delirium |
| Performance of the French version of the 4AT for screening the elderly for delirium in the emergency department. | Gagne, A. J. Voyer, P. Boucher, V. Nadeau, A. Carmichael, P. H. Pelletier, M. Gouin, E. Berthelot, S. Daoust, R. Wilchesky, M. Richard, H. Pelletier, I. Ballard, S. Lague, A. Emond, M.` | CJEM | 2018 | |
| Early rehabilitation to prevent postintensive care syndrome in patients with critical illness: a systematic review and meta-analysis | Fuke, R. Hifumi, T. Kondo, Y. Hatakeyama, J. Takei, T. Yamakawa, K. Inoue, S. Nishida, O. | BMJ Open | 2018 |
early rehabilitation |
| Effects of closed-loop intravenous anesthesia guided by Bispectral Index in adult patients on emergence delirium: A randomized controlled study. | Cotoia, A. Mirabella, L. Beck, R. Matrella, P. Assenzo, V. Hazot, T. C. Cinnella, G. Liu, N. Dambrosio, M. | Minerva Anestesiol | 2018 |
epidural catheter |
| Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study. | Collet, M. O. Caballero, J. Sonneville, R. Bozza, F. A. Nydahl, P. Schandl, A. Woien, H. Citerio, G. van den Boogaard, M. Hastbacka, J. Haenggi, M. Colpaert, K. Rose, L. Barbateskovic, M. Lange, T. Jensen, A. Krog, M. B. Egerod, I. Nibro, H. L. Wetterslev | Intensive Care Med | 2018 |
Cohort |
| Latent class analysis of the multivariate Delirium Index in long-term care settings. | Ciampi, A. Bai, C. Dyachenko, A. McCusker, J. Cole, M. G. Belzile, E. | Int Psychogeriatr | 2018 |
Delirium Index |
| Cognitive Decline after Delirium in Patients Undergoing Cardiac Surgery. | Brown, C. H. th Probert, J. Healy, R. Parish, M. Nomura, Y. Yamaguchi, A. Tian, J. Zehr, K. Mandal, K. Kamath, V. Neufeld, K. J. Hogue, C. W. | Anesthesiology | 2018 | |
| Screening for Delirium: Development and Validation of the Buffalo Delirium Scale for Use in a Home-Based Hospice Setting. | Breier, J. M. Meier, S. T. Kerr, C. W. Wright, S. T. Grant, P. C. Depner, R. M. | Am J Hosp Palliat Care | 2018 |
delirium |
| Improving Geriatric Care Processes on Two Medical-Surgical Acute Care Units: A Pilot Study. | Booth, K. A. Simmons, E. E. Viles, A. F. Gray, W. A. Kennedy, K. R. Biswal, S. H. Lowe, J. A. Xhaja, A. Kennedy, R. E. Brown, C. J. Flood, K. L. | J Healthc Qual | 2018 | |
| Screening for delirium with the Intensive Care Delirium Screening Checklist (ICDSC): Symptom profile and utility of individual items in the identification of delirium dependent on the level of sedation. | Boettger, S. Meyer, R. Richter, A. Fernandez, S. F. Rudiger, A. Schubert, M. Jenewein, J. Nunez, D. G. | Palliat Support Care | 2018 |
4th edition |
| The impact of psychomotor subtypes and duration of delirium on 6-month mortality in hip-fractured elderly patients. | Bellelli, G. Carnevali, L. Corsi, M. Morandi, A. Zambon, A. Mazzola, P. Galeazzi, M. Bonfanti, A. Massariello, F. Szabo, H. Oliveri, G. Haas, J. d'Oro, L. C. Annoni, G. | Int J Geriatr Psychiatry | 2018 |
delirium |
| Validation of the Brief Confusion Assessment Method for screening delirium in elderly medical patients in a German emergency department. | Baten, V. Busch, H. J. Busche, C. Schmid, B. Heupel-Reuter, M. Perlov, E. Brich, J. Kloppel, S. | Acad Emerg Med | 2018 |
bCAM |
| Association of intensive care unit delirium with sleep disturbance and functional disability after critical illness: an observational cohort study. | Altman, M. T. Knauert, M. P. Murphy, T. E. Ahasic, A. M. Chauhan, Z. Pisani, M. A. | Ann Intensive Care | 2018 |
Activities of daily living |
| Impact of Delirium on Patients Hospitalized for Myocardial Infarction: a Propensity Score Analysis of The National Inpatient Sample. | Abdullah, A. Eigbire, G. Salama, A. Wahab, A. Awadalla, M. Hoefen, R. Alweis, R. | Clin Cardiol | 2018 |
ICD-9-CM codes |
| The role of geriatrician-hospitalists in the care of older adults: A retrospective cohort study. | Sinvani, L. Carney, M. Kozikowski, A. Smilios, C. Patel, V. Qiu, G. Zhang, M. Babalola, O. Kandov, Y. Rosenberg, D. Wolf-Klein, G. Pekmezaris, R. | Arch Gerontol Geriatr | 2018 |
indwelling catheter |
| Clinical and laboratory characteristics associated with referral of hospitalized elderly to palliative care. | Arcanjo, S. P. Saporetti, L. A. Curiati, J. A. E. Jacob-Filho, W. Avelino-Silva, T. J. | Einstein (Sao Paulo) | 2018 | |
| Intraoperative cerebral oximetry-based management for optimizing perioperative outcomes: a meta-analysis of randomized controlled trials. | Zorrilla-Vaca, A. Healy, R. Grant, M. C. Joshi, B. Rivera-Lara, L. Brown, C. Mirski, M. A. | Canadian Journal of Anesthesia | 2018 |
ISRCTN01707446 |
| Postoperative delirium in total knee and hip arthroplasty patients: a study of perioperative modifiable risk factors. | Weinstein, S. M. Poultsides, L. Baaklini, L. R. Mörwald, E. E. Cozowicz, C. Saleh, J. N. Arrington, M. B. Poeran, J. Zubizarreta, N. Memtsoudis, S. G. | British Journal of Anaesthesia | 2018 |
total hip prosthesis |
| Impact of dexmedetomidine infusion during general anaesthesia on incidence of postoperative delirium in elderly patients after major non-cardiac surgery: study protocol of a randomised, double-blinded and placebo-controlled trial. | Wang, B. J. Li, C. J. Hu, J. Li, H. J. Guo, C. Wang, Z. H. Zhang, Q. C. Mu, D. L. Wang, D. X. | BMJ Open | 2018 |
elderly |
| Can education improve clinical practice concerning delirium in older hospitalised patients? Results of a pre-test post-test study on an educational intervention for nursing staff. | van Velthuijsen, E. L. Zwakhalen, S. M. G. Warnier, R. M. J. Ambergen, T. Mulder, W. J. Verhey, F. R. J. Kempen, Gijm | BMC Med Educ | 2018 |
Delirium |
| Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia. | Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T. | Cochrane Database of Systematic Reviews | 2018 |
chlorpromazine |
| Delirium in the Intensive Care Unit: Incidence, risk factors, and impact on outcome. | Tilouche, N. Hassen, M. F. Ali, H. B. S. Jaoued, O. Gharbi, R. El Atrous, S. | Indian Journal of Critical Care Medicine | 2018 |
endotracheal tube |
| Should This Patient Receive Prophylactic Medication to Prevent Delirium?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. | Tess, A. V. Mattison, M. L. P. Leo, J. R. Reynolds, E. E. | Ann Intern Med | 2018 | |
| Use of the CAM-ICU during daily sedation stops in mechanically ventilated patients as assessed and experienced by intensive care nurses - A mixed-methods study. | Steinseth, E. B. Hoye, S. Hov, R. | Intensive Crit Care Nurs | 2018 |
Assessment |
| Risk factors and outcome of postoperative delirium after transcatheter aortic valve replacement. | Stachon, P. Kaier, K. Zirlik, A. Reinohl, J. Heidt, T. Bothe, W. Hehn, P. Zehender, M. Bode, C. von Zur Muhlen, C. | Clin Res Cardiol | 2018 |
In-hospital mortality |
| Neurological Sequelae and Clinical Outcomes After Lung Transplantation. | Smith, P. J. Stonerock, G. L. Ingle, K. K. Saulino, C. K. Hoffman, B. Wasserman, B. Blumenthal, J. A. Palmer, S. M. Klapper, J. A. Hartwig, M. G. Esposito, V. R. Snyder, L. D. | Transplant Direct | 2018 | |
| Comparison of Ketamine- Versus Nonketamine-Based Sedation on Delirium and Coma in the Intensive Care Unit. | Shurtleff, V. Radosevich, J. J. Patanwala, A. E. | Journal of Intensive Care Medicine | 2018 |
adult |
| Postoperative delirium in elderly patients with critical limb ischemia undergoing major leg amputation: a retrospective study. | Shin, Y. H. Yoon, J. S. Jeon, H. J. Kim, Y. B. Kim, Y. S. Park, J. Y. | Korean J Anesthesiol | 2018 |
Amputation |
| The validity and reliability of the Arabic version of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU): A prospective cohort study | Selim, A. Kandeel, N. Elokl, M. Khater, M. S. Saleh, A. N. Bustami, R. Ely, E. W. | Int J Nurs Stud | 2018 |
Delirium |
| Validation of Caregiver-Centered Delirium Detection Tools: A Systematic Review. | Rosgen, B. Krewulak, K. Demiantschuk, D. Ely, E. W. Davidson, J. E. Stelfox, H. T. Fiest, K. M. | J Am Geriatr Soc | 2018 |
caregiver |
| Study protocol to assess the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units: a cluster-randomised, crossover trial (The ICU Visits Study). | Rosa, R. G. Falavigna, M. Robinson, C. C. da Silva, D. B. Kochhann, R. de Moura, R. M. Santos, M. M. S. Sganzerla, D. Giordani, N. E. Eugenio, C. Ribeiro, T. Cavalcanti, A. B. Bozza, F. Azevedo, L. C. P. Machado, F. R. Salluh, J. I. F. Pellegrini, J. A. S | BMJ Open | 2018 |
critical care |
| Attention, arousal and other rapid bedside screening instruments for delirium in older patients: a systematic review of test accuracy studies. | Quispel-Aggenbach, D. W. P. Holtman, G. A. Zwartjes, Haht Zuidema, S. U. Luijendijk, H. J. | Age & Ageing | 2018 | |
| Use of haloperidol versus atypical antipsychotics and risk of in-hospital death in patients with acute myocardial infarction: Cohort study | Park, Y. Bateman, B. T. Kim, D. H. Hernandez-Diaz, S. Patorno, E. Glynn, R. J. Mogun, H. Huybrechts, K. F. | BMJ | 2018 |
acetylsalicylic acid |
| Postictal delirium and violent behavior in patients with post-neurosurgical epilepsy. | Oueslati, B. Fekih-Romdhane, F. Ridha, R. | World Neurosurg | 2018 |
epilepsy |
| Factor Analysis of Delirium in Elderly, Using the Korean Version of Delirium Rating Scale-Revised-98. | Noh, G. Kwon, I. Lee, M. Ahn, S. H. Kim, J. L. | Psychiatry Investigation | 2018 |
Aged |
| Flexible Versus Restrictive Visiting Policies in ICUs: A Systematic Review and Meta-Analysis. | Nassar Junior, A. P. Besen, Bamp Robinson, C. C. Falavigna, M. Teixeira, C. Rosa, R. G. | Crit Care Med | 2018 | |
| Effectiveness of non-pharmacological strategies for managing delirium in hospitalized postoperative adults: An umbrella review protocol. | McNeil, J. Denis, A. M. Michel, U. Concert, C. M. | JBI Database of Systematic Reviews and Implementation Reports | 2018 |
adult |
| Genome-wide association identifies a novel locus for delirium risk. | McCoy, T. H. Hart, K. Pellegrini, A. Perlis, R. H. | Neurobiology of Aging | 2018 |
adult |
| Risk factors for postoperative delirium in patients undergoing free flap reconstruction for oral cancer. | Makiguchi, T. Yokoo, S. Kurihara, J. | Int J Oral Maxillofac Surg | 2018 |
delirium |
| Risk factors for mortality in elderly patients with hip fractures: a meta-analysis of 18 studies. | Liu, Y. Wang, Z. Xiao, W. | Aging Clin Exp Res | 2018 |
Elderly |
| Inflammatory markers in postoperative delirium (POD) and cognitive dysfunction (POCD): A meta-analysis of observational studies. | Liu, X. Yu, Y. Zhu, S. | PLoS One | 2018 | |
| Systematic review of prediction models for delirium in the older adult inpatient. | Lindroth, H. Bratzke, L. Purvis, S. Brown, R. Coburn, M. Mrkobrada, M. Chan, M. T. V. Davis, D. H. J. Pandharipande, P. Carlsson, C. M. Sanders, R. D. | BMJ Open | 2018 |
delirium |
| Age is the Most Significantly Associated Risk Factor with the Development of Delirium in Patients Hospitalized for More Than Five Days in Surgical Wards: Retrospective Cohort Study. | Kubota K, Suzuki A, Ohde S, Yamada U, Hosaka T, Okuno F, Fujitani I, Koitabashi A, Shimada G, Kishida A | Annals of surgery | 2017 |
nitrogen |
| Reduced ex vivo release of pro-inflammatory cytokines and elevated plasma interleukin-6 are inflammatory signatures of post-stroke delirium. | Kowalska, K. Klimiec, E. Weglarczyk, K. Pera, J. Slowik, A. Siedlar, M. Dziedzic, T. | J Neuroinflammation | 2018 |
Cytokines |
| Parkinson's disease-related non-motor features as risk factors for post-operative delirium in spinal surgery. | Kim, K. H. Kang, S. Y. Shin, D. A. Yi, S. Ha, Y. Kim, K. N. Sohn, Y. H. Lee, P. H. | PLoS One | 2018 | |
| Relationships between markers of neurologic and endothelial injury during critical illness and long-term cognitive impairment and disability. | Hughes, C. G. Patel, M. B. Brummel, N. E. Thompson, J. L. McNeil, J. B. Pandharipande, P. P. Jackson, J. C. Chandrasekhar, R. Ware, L. B. Ely, E. W. Girard, T. D. | Intensive Care Medicine | 2018 |
NCT00392795 |
| Incidence, Risk Factors, and Sequelae of Post-kidney Transplant Delirium. | Haugen, C. E. Mountford, A. Warsame, F. Berkowitz, R. Bae, S. G. Thomas A Brown, C. H. th Brennan, D. C. Neufeld, K. J. Carlson, M. C. Segev, D. L. McAdams-DeMarco, M. | J Am Soc Nephrol | 2018 |
clinical |
| Evaluation of an Intervention With Nurses for Delirium Detection After Cardiac Surgery. | Fraser, V. Cossette, S. Mailhot, T. Brisebois, A. Dubé, V. | Worldviews on evidence-based nursing | 2018 |
adult |
| Delirium clinical motor subtypes: a narrative review of the literature and insights from neurobiology. | FitzGerald JM | Aging & mental health | 2017 |
Screening and diagnosis |
| Are antipsychotics effective for the prevention of postoperative delirium? | Castro, V. Guinguis, R. Carrasco, M. | Medwave | 2018 | |
| Measuring mobility in older hospital patients with cognitive impairment using the de Morton Mobility Index. | Braun, T. Gruneberg, C. Thiel, C. Schulz, R. J. | BMC Geriatr | 2018 |
Dementia |
| Haloperidol for delirium in critically ill patients – protocol for a systematic review. | Barbateskovic, M. Kraus, S. R. Collet, M. O. Mathiesen, O. Jakobsen, J. C. Perner, A. Wetterslev, J. | Acta Anaesthesiol Scand | 2018 |
haloperidol |
| Dexmedetomidine vs morphine and midazolam in the prevention and treatment of delirium after adult cardiac surgery; a randomized, double-blinded clinical trial. | Azeem, T. M. A. Yosif, N. E. Alansary, A. M. Esmat, I. M. Mohamed, A. K. | Saudi J Anaesth | 2018 |
Dexmedetomidine |
| Psychometric properties of the Arabic version of the confusion assessment method for the intensive care unit (CAM-ICU). | Aljuaid, M. H. Deeb, A. M. Dbsawy, M. Alsayegh, D. Alotaibi, M. Arabi, Y. M. | BMC Psychiatry | 2018 |
Arabic |
| Postoperative delirium, learning, and anesthetic neurotoxicity: Some perspectives and directions. | Mutch, W. A. El-Gabalawy, R. M. Graham, M. R. | Frontiers in Neurology | 2018 |
adult |
| Designing a nurse-delivered delirium bundle: What intensive care unit staff, survivors, and their families think? | Bannon, L. McGaughey, J. Clarke, M. McAuley, D. F. Blackwood, B. | Aust Crit Care | 2018 |
Delirium |
| The 2014 updated version of the Confusion Assessment Method for the Intensive Care Unit compared to the 5th version of the Diagnostic and Statistical Manual of Mental Disorders and other current methods used by intensivists. | Chanques, G. Ely, E. W. Garnier, O. Perrigault, F. Eloi, A. Carr, J. Rowan, C. M. Prades, A. de Jong, A. Moritz-Gasser, S. Molinari, N. Jaber, S. | Ann Intensive Care | 2018 |
Critical care |
| Effect of a 24-h extended visiting policy on delirium in critically ill patients. | Westphal, G. A. Moerschberger, M. S. Vollmann, D. D. Inacio, A. C. Machado, M. C. Sperotto, G. Cavalcanti, A. B. Koenig, A. | Intensive Care Medicine | 2018 | |
| Effect of Sedation Regimen on Weaning from Mechanical Ventilation in the Intensive Care Unit. | Nunes, S. L. Forsberg, S. Blomqvist, H. Berggren, L. Sorberg, M. Sarapohja, T. Wickerts, C. J. | Clin Drug Investig | 2018 | |
| Validation of the korean version of the delirium motor subtype scale. | Kim, H. Lee, M. Kwon, I. S. Kim, J. L. | Psychiatry Investigation | 2018 |
aged |
| e-Screening revolution: A novel approach to developing a delirium screening tool in the intensive care unit. | Eeles, E. Gunn, H. Sutt, A. L. Pinsker, D. Flaws, D. Jarrett, P. Lye, I. Fraser, J. F. | Australasian Journal on Ageing | 2018 |
delirium |
| Sedation Intensity in the First 48 Hours of Mechanical Ventilation and 180-Day Mortality: A Multinational Prospective Longitudinal Cohort Study. | Shehabi, Y. Bellomo, R. Kadiman, S. Ti, L. K. Howe, B. Reade, M. C. Khoo, T. M. Alias, A. Wong, Y. L. Mukhopadhyay, A. McArthur, C. Seppelt, I. Webb, S. A. Green, M. Bailey, M. J. | Crit Care Med | 2018 | |
| Screening for delirium with the Intensive Care Delirium Screening Checklist (ICDSC): a re-evaluation of the threshold for delirium. | Boettger, S. Garcia Nunez, D. Meyer, R. Richter, A. Rudiger, A. Schubert, M. Jenewein, J. | Swiss Medical Weekly | 2018 | |
| Risk Factors of Postoperative Delirium in the Intensive Care Unit After Liver Transplantation. | Lee, H. Oh, S. Y. Yu, J. H. Kim, J. Yoon, S. Ryu, H. G. | World J Surg | 2018 | |
| Risk Factors for Postoperative Delirium After Deep Brain Stimulation Surgery for Parkinson's Disease. | Tanaka, M. Tani, N. Maruo, T. Oshino, S. Hosomi, K. Saitoh, Y. Kishima, H. | World Neurosurg | 2018 |
Deep Brain Stimulation |
| The relationship of delirium and risk factors in cardiology intensive care unit patients with the nursing workload. | Ozturk Birge, A. Beduk, T. | J Clin Nurs | 2018 |
Critical Care |
| Protocol for a single-centre prospective observational study of postoperative delirium following total joint arthroplasties among South East Asians. | Abdullah, H. R. Tan, S. R. Lee, S. J. Bin Abd Razak, H. R. Seet, R. H. Ying, H. Sethi, E. Sim, E. Y. | BMJ Open | 2018 |
*delirium |
| Preoperative statins are associated with a reduced risk of postoperative delirium following vascular surgery. | Lee, D. S. Lee, M. Y. Park, C. M. Kim, D. I. Kim, Y. W. Park, Y. J. | PLoS One | 2018 | |
| Predisposing and precipitating factors for delirium in community-dwelling older adults admitted to hospital with this condition: A prospective case series. | Magny, E. Le Petitcorps, H. Pociumban, M. Bouksani-Kacher, Z. Pautas, É Belmin, J. Bastuji-Garin, S. Lafuente-Lafuente, C. | PLoS One | 2018 |
aged |
| Predicting excess cost for older inpatients with clinical complexity: A retrospective cohort study examining cognition, comorbidities and complications | Bail, K. Draper, B. Berry, H. Karmel, R. Goss, J. | PLoS One | 2018 |
adult |
| Pilot Study of a Two-Step Delirium Detection Protocol Administered By Certified Nursing Assistants, Physicians, and Registered Nurses. | Fick, D. M. Inouye, S. K. McDermott, C. Zhou, W. Ngo, L. Gallagher, J. McDowell, J. Penrod, J. Siuta, J. Covaleski, T. Marcantonio, E. R. | J Gerontol Nurs | 2018 | |
| Perioperative hyperglycaemia and neurocognitive outcome after surgery: a systematic review. | Hermanides, J. Qeva, E. Preckel, B. Bilotta, F. | Minerva Anestesiol | 2018 | |
| Low-dose Nocturnal Dexmedetomidine Prevents ICU Delirium: A Randomized, Placebo-controlled Trial. | Skrobik, Y. Duprey, M. S. Hill, N. S. Devlin, J. W. | Am J Respir Crit Care Med | 2018 |
delirium, sleep, intensive care, dexmedetomidine, randomized controlled trial |
| Low peripheral levels of insulin growth factor-1 are associated with high incidence of delirium among elderly patients: A systematic review and meta-analysis. | Li, D. J. Tseng, P. T. Stubbs, B. Chen, T. Y. Lin, P. Y. Chen, S. L. Thompson, T. Adamis, D. Chu, C. S. | Arch Gerontol Geriatr | 2018 |
Biomarker |
| Is anemia associated with cognitive impairment and delirium among older acute surgical patients? | Myint, P. K. Owen, S. McCarthy, K. Pearce, L. Moug, S. J. Stechman, M. J. Hewitt, J. Carter, B. | Geriatrics & Gerontology International | 2018 |
anemia |
| Intraoperative Sedation With Dexmedetomidine is Superior to Propofol for Elderly Patients Undergoing Hip Arthroplasty: A Prospective Randomized Controlled Study. | Mei, B. Meng, G. Xu, G. Cheng, X. Chen, S. Zhang, Y. Zhang, M. Liu, X. Gu, E. | Clin J Pain | 2018 | |
| Infrared pupillometry helps to detect and predict delirium in the post-anesthesia care unit. | Yang E, Kreuzer M, Hesse S, Davari P, Lee SC, García PS | Journal of clinical monitoring and computing | 2017 |
PLR-200 |
| Influence of Physical Restraint on Delirium of Adult Patients in ICU: A Nested Case-Control Study. | Pan, Y. Jiang, Z. Changrong, Y. Wang, L. Zhang, J. Zhou, J. Tao, M. Quan, M. Wu, Q. | J Clin Nurs | 2018 |
Delirium |
| Incidence of delirium in the Canadian emergency department and its consequences on hospital length of stay: A prospective observational multicentre cohort study. | Émond, M. Boucher, V. Carmichael, P. H. Voyer, P. Pelletier, M. Gouin, É Daoust, R. Berthelot, S. Lamontagne, M. E. Morin, M. Lemire, S. Minh Vu, T. T. Nadeau, A. Rheault, M. Juneau, L. Le Sage, N. Lee, J. | BMJ Open | 2018 |
aged |
| Impact of timing and duration of postoperative delirium: a retrospective observational study | Lee, H. Ju, J. W. Oh, S. Y. Kim, J. Jung, C. W. Ryu, H. G. | Surgery | 2018 | |
| Frequency and risk factors for subsyndromal delirium in an intensive care unit. | Yamada, C. Iwawaki, Y. Harada, K. Fukui, M. Morimoto, M. Yamanaka, R. | Intensive Crit Care Nurs | 2018 |
Delirium |
| Focusing on Inattention: The Diagnostic Accuracy of Brief Measures of Inattention for Detecting Delirium. | Marra, A. Jackson, J. C. Ely, E. W. Graves, A. J. Schnelle, J. F. Dittus, R. S. Wilson, A. Han, J. H. | J Hosp Med | 2018 | |
| Feasibility of Cognitive Training in Critically Ill Patients: A Pilot Study. | Wassenaar, A. Rood, P. Boelen, D. Schoonhoven, L. Pickkers, P. van den Boogaard, M. | Am J Crit Care | 2018 | |
| Evaluation of a sound environment intervention in an ICU: A feasibility study. | Johansson, L. Lindahl, B. Knutsson, S. Ogren, M. Persson Waye, K. Ringdal, M. | Aust Crit Care | 2018 |
Complex intervention |
| Effects of Haloperidol on Delirium in Adult Patients: A Systematic Review and Meta-analysis. | Shen, Y. Z. Peng, K. Zhang, J. Meng, X. W. Ji, F. | Med Princ Pract | 2018 | |
| The effect of the timing and dose of dexmedetomidine on postoperative delirium in elderly patients after laparoscopic major non-cardiac surgery: A double blind randomized controlled study. | Lee, C. Lee, C. H. Lee, G. Lee, J. Hwang, J. | J Clin Anesth | 2018 |
Cytokine |
| Effect of organisational factors on the variation in incidence of delirium in intensive care unit patients: A systematic review and meta-regression analysis. | Rood, P. Huisman-de Waal, G. Vermeulen, H. Schoonhoven, L. Pickkers, P. van den Boogaard, M. | Aust Crit Care | 2018 |
Critical care |
| Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU: A Single-Center Randomized Placebo-Controlled Trial. | Nishikimi, M. Numaguchi, A. Takahashi, K. Miyagawa, Y. Matsui, K. Higashi, M. Makishi, G. Matsui, S. Matsuda, N. | Crit Care Med | 2018 | |
| Diagnostic accuracy of delirium assessment methods in critical care patients | Barman, A. Pradhan, D. Bhattacharyya, P. Dey, S. Bhattacharjee, A. Tesia, S. S. Mitra, J. K. | Journal of Critical Care | 2018 |
Acute Physiology and Chronic Health Evaluation II |
| Delirium in ICU Patients Following Cardiac Surgery: An Observational Study. | Simeone, S. Pucciarelli, G. Perrone, M. Rea, T. Gargiulo, G. Guillari, A. Castellano, G. Di Tommaso, L. Niola, M. Iannelli, G. | J Clin Nurs | 2018 |
Icu |
| Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study. | Girard, T. D. Thompson, J. L. Pandharipande, P. P. Brummel, N. E. Jackson, J. C. Patel, M. B. Hughes, C. G. Chandrasekhar, R. Pun, B. T. Boehm, L. M. Elstad, M. R. Goodman, R. B. Bernard, G. R. Dittus, R. S. Ely, E. W. | Lancet Respir Med | 2018 | |
| Nursing perspectives on the confusion assessment method: a qualitative focus group study. | Wong, E. K. Lee, J. Y. Surendran, A. S. Nair, K. Della Maestra, N. Migliarini, M. St Onge, J. A. Patterson, C. J. | Age Ageing | 2018 | |
| Detection and management of hyperactive and hypoactive delirium in older patients during hospitalization: a retrospective cohort study evaluating daily practice. | van Velthuijsen, E. L. Zwakhalen, S. M. G. Mulder, W. J. Verhey, F. R. J. Kempen, Gijm | Int J Geriatr Psychiatry | 2018 |
care as usual |
| Glucose variability during delirium in diabetic and non-diabetic intensive care unit patients: A prospective cohort study. | van Keulen, K. Knol, W. Belitser, S. V. Zaal, I. J. van der Linden, P. D. Heerdink, E. R. Egberts, T. C. G. Slooter, A. J. C. | PLoS One | 2018 | |
| Evaluating the use of dexmedetomidine for the reduction of delirium: An integrative review. | Pavone, K. J. Cacchione, P. Z. Polomano, R. C. Winner, L. Compton, P. | Heart Lung | 2018 |
Delirium |