What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions
- Authors
- Vasunilashorn, S. M. Ngo, L. H. Inouye, S. K. Fong, T. G. Jones, R. N. Dillon, S. T. Libermann, T. A. O'Connor, M. Arnold, S. E. Xie, Z. Marcantonio, E. R.
- Year
- 2019
- Journal
- Alzheimers Dement
- Abstract
INTRODUCTION: Apolipoprotein E (APOE) status may modify the risk of postoperative delirium conferred by inflammation. METHODS: We tested whether APOE modifies the established association between C-reactive protein (CRP) and delirium incidence, severity, and duration in 553 noncardiac surgical patients aged 70 and older. High postoperative plasma CRP (>/=234.12 mg/L) was defined by the highest sample-based quartile. Delirium was determined using the Confusion Assessment Method and chart review, and severity was determined by the Confusion Assessment Method–Severity score. RESULTS: APOE epsilon4 carrier prevalence was 19%, and postoperative delirium occurred in 24%. The relationship between CRP and delirium incidence, severity, and duration differed by epsilon4 status. Among epsilon4 carriers, there was a strong relationship between high CRP (vs. low CRP) and delirium incidence (relative risk [95% confidence interval], 3.0 [1.4-6.7]); however, no significant association was observed among non-epsilon4 carriers (relative risk [95% CI], 1.2 [0.8-1.7]). DISCUSSION: Our findings raise the possibility that APOE epsilon4 carrier status may modify the relationship between postoperative day 2 CRP levels and postoperative delirium.
- PMID
- Keywords
Apolipoprotein E
C-reactive protein
Delirium
Gene-protein interaction
Inflammation
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Undiagnosed delirium is frequent and difficult to predict: Results from a prevalence survey of a tertiary hospital. | Lange, P. W. Lamanna, M. Watson, R. Maier, A. B. | J Clin Nurs | 2019 |
Undiagnosed delirium |