What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Delirium associated with concomitant use of duloxetine and bupropion in an elderly patient.
- Authors
- Ma SP, Tsai CJ, Chang CC, Hsu WY
- Year
- 2017
- Journal
- Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
- Abstract
Delirium is common in daily practice. Drug-induced delirium constitutes approximately one-third of all cases of delirium. In cases characterized by the limited efficacy of a single antidepressant, a combination of two antidepressants is required, which may induce a complex drug-drug interaction. We reviewed a case of duloxetine- and bupropion-related delirium in an elderly male patient in our clinical practice. The patient was diagnosed with major depressive disorder and was treated with duloxetine. However, he developed delirium 10 days after bupropion was added to his treatment regimen. Three days after the cessation of bupropion, his delirious condition gradually improved. Duloxetine and bupropion are both cytochrome P450 2D6 inhibitors that may result in a higher level of hydroxybupropion. An increased level of hydroxybupropion may cause the elevation of dopamine and a risk of subsequent delirium. We should be aware of the risk of delirium induced by drug-drug interactions.
- PMID
- Keywords
Aged, 80 and over, Antidepressive Agents, Second-Generation, administration & dosage, Bupropion, administration & dosage, Cytochrome P-450 CYP2D6 Inhibitors, administration & dosage, Delirium, chemically induced, Depressive Disorder, Major, diagnosis, Dose-Response Relationship, Drug, Drug Interactions, Duloxetine Hydrochloride, administration & dosage, Humans, Male, Treatment Outcome
- Page(s)
- 130-132
- Volume
- 17
- Issue
- 2
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Undiagnosed delirium is frequent and difficult to predict: Results from a prevalence survey of a tertiary hospital. | Lange, P. W. Lamanna, M. Watson, R. Maier, A. B. | J Clin Nurs | 2019 |
Undiagnosed delirium |