NIDUS Delirium Bibliography

Delirium Bibliography books graphic What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title: Effects of gabapentin on slow-wave sleep period in critically ill adult patients: A randomized controlled trial

Authors: Susantitapong, K. Dilokpattanamongkol, P. Sutherasan, Y. Liamsombut, S. Suthisisang, C.

Year: 2024

Journal: Clin Transl Sci

Abstract: Sleep deprivation is a prevalent problem in critically ill patients, which leads to delayed recovery and delirium. Slow-wave sleep (SWS) is essential to energy restoration, tissue repair, and immune system strengthening. This study aimed to investigate the effects of gabapentin on SWS in critically ill patients. We performed a prospective open-label randomized controlled study to compare SWS and the clinical outcomes of gabapentin versus a control intervention in critically ill adult patients admitted to the intensive care unit (ICU) within 24 h. The patients’ characteristics and sleep-related outcomes were recorded. The sleep-related outcomes, namely, bispectral analysis (BIS), the Richards-Campbell Sleep Questionnaire (RCSQ), and insulin-like growth factor-1 (IGF-1) levels, were evaluated. Furthermore, clinical outcomes and safety were assessed. Sixty patients from 348 cases were eligible for randomization. On day 3 of the study, patients in the gabapentin group had significantly increased SWS (66.79 vs. 0.00 min; p < 0.001), total sleep time (TST) (331.39 vs. 46.16 min; p = 0.001), RCSQ score (55.05 ± 20.18 vs. 32.80 ± 15.31; p < 0.001), and IGF-1 concentrations (84.33 ± 12.40 vs. 44.00 ± 10.20 ng/mL, p < 0.001) compared with the control group. Improvements in clinical outcomes, such as delirium, ICU-free days, and mechanical ventilator-free days, were observed; however, these differences did not reach statistically significant. Gabapentin at bedtime increased SWS, TST, and IGF-1 concentrations in critically ill patients. This regimen might be beneficial to critically ill patients for improving their sleep quality.

PMID: PMID: 38803031

PMCID: PMC11130453

Keywords: Humans
*Gabapentin/therapeutic use/administration & dosage
*Critical Illness
Male
Female
Middle Aged
Aged
Prospective Studies
*Sleep, Slow-Wave/drug effects
Adult
Intensive Care Units
Insulin-Like Growth Factor I/metabolism/analysis
Sleep Deprivation/drug therapy/physiopathology
Treatment Outcome

Page(s)

Volume

Issue

Total Records Found: 6389, showing 100 per page
Title	Authors	Journal	Year	Keywords
Incidence and clinical significance of postoperative delirium after brain tumor surgery.	Budenas, A. Tamasauskas, S. Sliauzys, A. Navickaite, I. Sidaraite, M. Pranckeviciene, A. Deltuva, V. P. Tamasauskas, A. Bunevicius, A.	Acta Neurochir (Wien)	2018	Brain tumor Neurosurgery Postoperative delirium Short-term outcomes
Role of perceived stress in postoperative delirium: an investigation among elderly patients.	Banjongrewadee, M. Wongpakaran, N. Wongpakaran, T. Pipanmekaporn, T. Punjasawadwong, Y. Mueankwan, S.	Aging Ment Health	2018	Perceived stress delirium elderly surgery
Predictors and Sequelae of Postoperative Delirium in Geriatric Hip Fracture Patients.	Arshi, A. Lai, W. C. Chen, J. B. Bukata, S. V. Stavrakis, A. I. Zeegen, E. N.	Geriatr Orthop Surg Rehabil	2018	delirium fragility fractures geriatric trauma systems of care trauma surgery conflicts of interest with respect to the research, authorship, and/or publication of this article.
Operative and anaesthetic factors influencing on delirium in the intensive care unit: An Analysis of electronic health records.	An, Y. S. Jin, Y. Jin, T. Hur, E. Y. Lee, S. M.	J Clin Nurs	2018	delirium electronic health records intensive care unit risk factor
Effect of anticholinergic burden on treatment modification, delirium and mortality in newly diagnosed dementia patients starting a cholinesterase inhibitor: a population-based study.	Ah, Y. M. Suh, Y. Jun, K. Hwang, S. Lee, J. Y.	Basic Clin Pharmacol Toxicol	2018	Alzheimer’s disease anticholinergics cholinesterase inhibitors delirium mortalitya
Postoperative Delirium in Individuals Undergoing Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.	Abawi, M. Pagnesi, M. Agostoni, P. Chiarito, M. van Jaarsveld, R. C. van Dongen, C. S. Slooter, A. J. C. Colombo, A. Kooistra, N. H. M. Doevendans, Pafm Latib, A. Stella, P. R.	J Am Geriatr Soc	2018	Tavr cognition delirium transcatheter aortic valve replacement
Effect of goal-directed fluid therapy on early cognitive function in elderly patients with spinal stenosis: A Case-Control Study.	Zhang, N. Liang, M. Zhang, D. D. Xiao, Y. R. Li, Y. Z. Gao, Y. G. Cai, H. D. Lin, X. Z. Lin, C. Z. Zeng, K. Wu, X. D.	Int J Surg	2018	Elderly patients Goal-directed fluid therapy Postoperative cognitive dysfunction Spinal stenosis
Rehospitalization following a stay in geriatric rehabilitation wards: rates and predictive factors.	Tardivel, M. Muller, F. Tortrat, D. Lechowski, L. Teillet, L.	Geriatr Psychol Neuropsychiatr Vieil	2018	geriatric post-acute and rehabilitation care wards predictive factors rehospitalization
Elimination of Routine Benzodiazepine Administration for Nonprocedural Sedation in a Trauma Intensive Care Unit Is Feasible.	McGinn, K. Davis, S. N. Terrry, E. Simmons, J. Brevard, S.	Am Surg	2018	Adult Benzodiazepines/therapeutic use Critical Care Delirium/etiology/prevention & control Feasibility Studies Female Humans Hypnotics and Sedatives/therapeutic use Injury Severity Score Male Psychomotor Agitation/etiology/prevention & control Retrospective Studies Trauma Centers Wounds and Injuries/psychology/therapy
Can Chaotic Analysis of Electroencephalogram Aid the Diagnosis of Encephalopathy?	Jacob, J. E. Cherian, A. Gopakumar, K. Iype, T. Yohannan, D. G. Divya, K. P.	Neurology Research International	2018	adult article brain function case control study clinical article clinical feature clinical indicator controlled study diagnostic accuracy electroencephalogram electroencephalography female human male metabolic encephalopathy randomized controlled trial retrospective study support vector machine
Hospital outcomes of older people with cognitive impairment: An integrative review.	Fogg, C. Griffiths, P. Meredith, P. Bridges, J.	Int J Geriatr Psychiatry	2018	cognitive dysfunction dementia integrative review older people outcomes patient admission
Physostigmine is superior to non-antidote therapy in the management of antimuscarinic delirium: a prospective study from a regional poison center.	Boley, S. P. Olives, T. D. Bangh, S. A. Fahrner, S. Cole, J. B.	Clin Toxicol	2018	Physostigmine anticholinergic toxidrome antimuscarinic delirium poison center
Cholinesterase inhibitors for the treatment of delirium in non-ICU settings.	Yu, A. Wu, S. Zhang, Z. Dening, T. Zhao, S. Pinner, G. Xia, J. Yang, D.	Cochrane Database of Systematic Reviews	2018
Perioperative dexmedetomidine reduces delirium after cardiac surgery: A meta-analysis of randomized controlled trials	Wu, M. Liang, Y. Dai, Z. Wang, S.	J Clin Anesth	2018	Cardiac surgery Delirium Dexmedetomidine Meta-analysis
Diabetes and Glucose Dysregulation and Transition to Delirium in ICU Patients.	van Keulen, K. Knol, W. Belitser, S. V. van der Linden, P. D. Heerdink, E. R. Egberts, T. C. G. Slooter, A. J. C.	Crit Care Med	2018
Factors associated with delirium in critical patients in a health institution in Bucaramanga, Colombia.	Torres-Contreras, C. C. Paez-Esteban, A. N. Hinestrosa-Diaz Del Castillo, A. Rincon-Romero, M. K. Amaris-Vega, A. Martinez-Patino, J. P.	Enferm Intensiva	2018	Delirium Incidence Incidencia Intensive Care Unit Unidad de Cuidados Intensivos
The effect of preoperative cognitive impairment and type of vascular surgery procedure on postoperative delirium with associated cost implications.	Styra, R. Larsen, E. Dimas, M. A. Baston, D. Elgie-Watson, J. Flockhart, L. Lindsay, T. F.	J Vasc Surg	2018	Cognition Delirium MoCA Preoperative Vascular surgery
Rate and risk factors for a hyperactivity delirium in patients with aneurysmal subarachnoid haemorrhage.	Sauvigny, T. Mohme, M. Grensemann, J. Duhrsen, L. Regelsberger, J. Kluge, S. Schmidt, N. O. Westphal, M. Czorlich, P.	Neurosurg Rev	2018	Delirium Hydrocephalus Microsurgical clipping Neurocritical care Rass Subarachnoid haemorrhage
Delirium in Postoperative Patients Admitted to the Intensive Care Unit.	Romanauski, T. R. Martin, E. E. Sprung, J. Martin, D. P. Schroeder, D. R. Weingarten, T. N.	Am Surg	2018	Adult Aged Delirium/epidemiology Female Humans Intensive Care Units International Classification of Diseases Length of Stay Male Middle Aged Postoperative Complications/epidemiology Retrospective Studies Risk Factors Surgical Procedures, Operative/adverse effects/statistics & numerical data
Degree of implementation of preventive strategies for post-ICU syndrome: Multi-centre, observational study in Spain.	Raurell-Torreda, M. Arias-Rivera, S. Marti, J. D. Frade-Mera, M. J. Zaragoza-Garcia, I. Gallart, E. Velasco-Sanz, T. R. San Jose-Arribas, A. Blazquez-Martinez, E.	Enferm Intensiva	2018	Critical illness Early mobility Enfermedad critica Enfermeria Intensive Care Units Movilizacion precoz Nursing Physical therapy Rehabilitacion Rehabilitation Terapia fisica Unidades de Cuidados Intensivos
Surgical delay is a risk factor of delirium in hip fracture patients with mild-moderate cognitive impairment.	Pioli, G. Bendini, C. Giusti, A. Pignedoli, P. Cappa, M. Iotti, E. Ferri, M. A. Bergonzini, E. Sabetta, E.	Aging Clin Exp Res	2018	Delirium Dementia Hip fracture Orthogeriatric Osteoporosis
Predictors of Delirium Development in Older Medical Inpatients: Readily Identifiable Factors at Admission.	O’Regan, Niamh A. Fitzgerald, James Adamis, Dimitrios Molloy, David William Meagher, David Timmons, Suzanne Montero-Odasso, Manuel	Journal of Alzheimer's Disease	2018
Processed Electroencephalogram Monitoring and Postoperative Delirium: A Systematic Review and Meta-analysis.	MacKenzie, K. K. Britt-Spells, A. M. Sands, L. P. Leung, J. M.	Anesthesiology	2018
The influence of oxygen delivery during cardiopulmonary bypass on the incidence of delirium in CABG patients; a retrospective study	Leenders, J. Overdevest, E. van Straten, B. Golab, H.	Perfusion	2018	Cabg cardiopulmonary bypass delirium oxygen delivery
Safety of brotizolam in hospitalized patients.	Lavon, O. Bejel, S.	European Journal of Clinical Pharmacology	2018	benzodiazepine derivative brotizolam aged article artificial ventilation cohort analysis comorbidity controlled study delirium drug safety falling female hospital patient human insomnia internal medicine major clinical study male multivariate logistic regression analysis outcome assessment prescription priority journal respiratory tract disease retrospective study risk benefit analysis risk factor side effect
Early delirium after cardiac surgery: An analysis of incidence and risk factors in elderly (≥65 years) and very elderly (≥80 years) patients.	Kotfis, K. Szylińska, A. Listewnik, M. Strzelbicka, M. Brykczyński, M. Rotter, I. Żukowski, M.	Clinical Interventions in Aging	2018	creatinine age aged artery disease article atrial fibrillation clinical outcome cohort analysis controlled study creatinine blood level delirium diabetes mellitus female heart ejection fraction heart surgery hospitalization human incidence intensive care unit major clinical study male mortality rate pneumonia postoperative complication postoperative period prospective study retrospective study risk factor tertiary care center very elderly
ICU delirium - a diagnostic and therapeutic challenge in the intensive care unit.	Kotfis, K. Marra, A. Ely, E. W.	Anaesthesiol Intensive Ther	2018	Cam-icu Icu critical care delirium monitoring
Melatonin and sleep in preventing hospitalized delirium: A randomized clinical trial.	Jaiswal, S. J. McCarthy, T. J. Wineinger, N. E. Kang, D. Y. Song, J. Garcia, S. van Niekerk, C. J. Lu, C. Y. Loeks, M. Owens, R. L.	Am J Med	2018	Delirium Melatonin Sleep
Intraoperative ketamine administration to prevent delirium or postoperative cognitive dysfunction: A systematic review and meta-analysis.	Hovaguimian, F. Tschopp, C. Beck-Schimmer, B. Puhan, M.	Acta Anaesthesiol Scand	2018	cognitive dysfunction ketamine meta-analysis postoperative delirium
The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses.	Hov, K. R. Neerland, B. E. Andersen, A. M. Undseth, O. Wyller, V. B. MacLullich, A. M. J. Skovlund, E. Qvigstad, E. Wyller, T. B.	BMC Pharmacol Toxicol	2018	Clonidine Delirium Pharmacokinetic Rct
Delirium's Arousal Subtypes and Their Relationship with 6-Month Functional Status and Cognition.	Han, J. H. Hayhurst, C. J. Chandrasekhar, R. Hughes, C. G. Vasilevskis, E. E. Wilson, J. E. Schnelle, J. F. Dittus, R. S. Ely, E. W.	Psychosomatics	2018	aged arousal article cognitive defect cohort analysis controlled study daily life activity emergency ward female functional status hospital patient hospitalization human major clinical study male multiple linear regression analysis prospective study questionnaire Richmond Agitation Sedation Scale secondary analysis
Intraoperative electroencephalogram suppression at lower volatile anaesthetic concentrations predicts postoperative delirium occurring in the intensive care unit.	Fritz, B. A. Maybrier, H. R. Avidan, M. S.	British Journal of Anaesthesia	2018	NCT02032030 inhalation anesthetic agent adult aged article bispectral index cohort analysis controlled study elective surgery electroencephalogram electroencephalography monitoring electronic medical record female human incidence intensive care unit major clinical study male postoperative delirium prediction priority journal retrospective study risk factor sleep disordered breathing
Efficacy of perioperative dexmedetomidine on postoperative delirium: systematic review and meta-analysis with trial sequential analysis of randomised controlled trials.	Duan, X. Coburn, M. Rossaint, R. Sanders, R. D. Waesberghe, J. V. Kowark, A.	British Journal of Anaesthesia	2018	adult article bradycardia Cochrane Library controlled study drug efficacy drug therapy female hospital mortality human hypotension incidence intensive care unit length of stay male Medline meta analysis postoperative delirium postoperative period randomized controlled trial (topic) registration risk assessment risk factor sedation sequential analysis surgery surgical patient systematic review dexmedetomidine
Long-term sequelae of acute respiratory distress syndrome caused by severe community-acquired pneumonia: Delirium-associated cognitive impairment and post-traumatic stress disorder.	Denke, C. Balzer, F. Menk, M. Szur, S. Brosinsky, G. Tafelski, S. Wernecke, K. D. Deja, M.	J Int Med Res	2018	Community-acquired pneumonia analgesia delirium health-related quality of life long-term outcome post-traumatic stress disorder
A Performing Arts Intervention Improves Cognitive Dysfunction in 50 Hospitalized Older Adults.	Danila, M. I. Melnick, J. A. Mudano, A. Flood, K. Booth, K. Kirklin, K. Saag, K. G.	Innov Aging	2018	Alternative and complementary medicine/care/therapy Delirium Quality of care
Nursing perspectives on the confusion assessment method: a qualitative focus group study.	Wong, E. K. Lee, J. Y. Surendran, A. S. Nair, K. Della Maestra, N. Migliarini, M. St Onge, J. A. Patterson, C. J.	Age Ageing	2018
Detection and management of hyperactive and hypoactive delirium in older patients during hospitalization: a retrospective cohort study evaluating daily practice.	van Velthuijsen, E. L. Zwakhalen, S. M. G. Mulder, W. J. Verhey, F. R. J. Kempen, Gijm	Int J Geriatr Psychiatry	2018	care as usual delirium management prevalence psychomotor subtypes
Glucose variability during delirium in diabetic and non-diabetic intensive care unit patients: A prospective cohort study.	van Keulen, K. Knol, W. Belitser, S. V. Zaal, I. J. van der Linden, P. D. Heerdink, E. R. Egberts, T. C. G. Slooter, A. J. C.	PLoS One	2018
Evaluating the use of dexmedetomidine for the reduction of delirium: An integrative review.	Pavone, K. J. Cacchione, P. Z. Polomano, R. C. Winner, L. Compton, P.	Heart Lung	2018	Delirium Dexmedetomidine Elderly Intensive care Mechanical ventilation Mortality
Delirium Monitoring in Neurocritically Ill Patients: A Systematic Review.	Patel, M. B. Bednarik, J. Lee, P. Shehabi, Y. Salluh, J. I. Slooter, A. J. Klein, K. E. Skrobik, Y. Morandi, A. Spronk, P. E. Naidech, A. M. Pun, B. T. Bozza, F. A. Marra, A. John, S. Pandharipande, P. P. Ely, E. W.	Crit Care Med	2018
Poststroke Delirium Clinical Motor Subtypes: The PRospective Observational POLIsh Study (PROPOLIS).	Pasinska, P. Kowalska, K. Klimiec, E. Wilk, A. Szyper-Maciejowska, A. Dziedzic, T. Klimkowicz-Mrowiec, A.	J Neuropsychiatry Clin Neurosci	2018	Delirium Delirium subtype Risk Factors Stroke and Other Cerebral Vascular Disease (Neuropsychiatric Aspects)
A systematic review of neuroimaging in delirium: predictors, correlates and consequences.	Nitchingham A, Kumar V, Shenkin S, Ferguson KJ, Caplan GA	International journal of geriatric psychiatry	2017	delirium neuroimaging
The effect of dexmedetomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis.	Ng, K. T. Shubash, C. J. Chong, J. S.	Anaesthesia	2018	adult agitation anxiety article bradycardia case study data synthesis delirium drug therapy Embase female human hypotension incidence intensive care unit male Medline meta analysis mortality observational study randomized controlled trial (topic) sequential analysis systematic review dexmedetomidine
A Point Prevalence Study of Delirium in Italian Nursing Homes.	Morichi, V. Fedecostante, M. Morandi, A. Di Santo, S. G. Mazzone, A. Mossello, E. Bo, M. Bianchetti, A. Rozzini, R. Zanetti, E. Musicco, M. Ferrari, A. Ferrara, N. Trabucchi, M. Cherubini, A. Bellelli, G.	Dementia and Geriatric Cognitive Disorders	2018	neuroleptic agent aged article Assessment Test for Delirium and Cognitive Impairment controlled study delirium Delirium Motor Subtype Scale dementia education female functional disease human immobility Italy major clinical study male malnutrition neurologic disease assessment nursing home prevalence priority journal psychopharmacotherapy very elderly
Increased Readmission Risk and Healthcare Cost for Delirium Patients without Immediate Hospitalization in the Emergency Department.	Ma, I. C. Chen, K. C. Chen, W. T. Tsai, H. C. Su, C. C. Lu, R. B. Chen, P. S. Chang, W. H. Yang, Y. K.	Clin Psychopharmacol Neurosci	2018	Delirium Health care costs Hospital emergency service Re-hospitalization Risk factors
The effect of chronotherapy on delirium in critical care - a systematic review.	Luther R, McLeod A	Nursing in critical care	2017	Adult intensive care practice development/innovation psychological issues during and after intensive care sensory imbalance
Intraoperative use of dexmedetomidine for the prevention of emergence agitation and postoperative delirium in thoracic surgery: a randomized-controlled trial.	Kim, J. A. Ahn, H. J. Yang, M. Lee, S. H. Jeong, H. Seong, B. G.	Canadian Journal of Anesthesia	2019	adult antiinflammatory activity article clinical research controlled study double blind procedure drug therapy emergence agitation female human human tissue incidence information service lung lobectomy major clinical study male postoperative delirium prevention protein blood level randomized controlled trial recovery room registration risk factor Sedation Agitation Scale surgery visually impaired person dexmedetomidine endogenous compound epinephrine interleukin 10 interleukin 6 interleukin 8 noradrenalin sevoflurane sodium chloride
Delirium following total joint replacement surgery.	Huang, J. Sprung, J. Weingarten, T. N.	Bosn J Basic Med Sci	2019
Delirium management: Let's get physical? A systematic review and meta-analysis.	Haley, M. N. Casey, P. Kane, R. Y. Darzins, P. Lawler, K.	Australas J Ageing	2019	delirium exercise physical activity physical mobility physical therapy
Increasing Light Exposure for the Prevention of Delirium: A Systematic Review.	Groves, R. L.	Dimensions of Critical Care Nursing	2019	adult aged article Cinahl delirium female hospital patient human illumination incidence light exposure male Medline neurologic disease phototherapy pilot study prevention PsycINFO Scopus sunlight systematic review
Perioperative Risk Factors for Postoperative Delirium in Patients Undergoing Esophagectomy.	Fuchita, M. Khan, S. H. Perkins, A. J. Gao, S. Wang, S. Kesler, K. A. Khan, B. A.	Ann Thorac Surg	2019
Delirium and Alzheimer's Disease: A Proposed Model for Shared Pathophysiology.	Fong, T. G. Vasunilashorn, S. M. Libermann, T. Marcantonio, E. R. Inouye, S. K.	Int J Geriatr Psychiatry	2019	biomarkers delirium dementia
Diagnostic Performance and Utility of Quantitative EEG Analyses in Delirium: Confirmatory Results From a Large Retrospective Case-Control Study.	Fleischmann, R. Tränkner, S. Bathe-Peters, R. Rönnefarth, M. Schmidt, S. Schreiber, S. J. Brandt, S. A.	Clinical EEG and Neuroscience	2019	electroencephalograph Galileo.NET adult aged area under the curve article case control study central nervous system infection cerebrovascular accident controlled study data analysis software delirium dementia diagnostic accuracy diagnostic test accuracy study diagnostic value electroencephalogram electroencephalography electrophysiology female human hypoxic ischemic encephalopathy major clinical study male migraine Parkinson disease posterior reversible encephalopathy syndrome predictive value priority journal receiver operating characteristic reliability retrospective study seizure sensitivity and specificity split half correlation virus encephalitis
Differences in potential biomarkers of delirium between acutely ill medical and elective cardiac surgery patients.	Egberts, A. Osse, R. J. Fekkes, D. Tulen, J. H. M. van der Cammen, T. J. M. Mattace-Raso, F. U. S.	Clin Interv Aging	2019	delirium inflammation neopterin oxidative stress renal function
Translation and validation of the tibetan confusion assessment method for the intensive care unit (CAM-ICU).	Danzeng, Q. Z. Cui, N. Wang, H. Pan, W. J. Long, Y. Deji, Y. Z. Ze, C. Ren, Z.	Chin Med J (Engl)	2019
Intra-operative Blood Transfusion Predicts Post-Operative Delirium among Older Patients Undergoing Elective Orthopedic Surgery: a Prospective Cohort Study.	Chou, M. Y. Wang, Y. C. Peng, L. N. Liang, C. K. Chu, C. S. Liao, M. C. Lin, Y. T. Hsu, C. J. Chen, L. K.	Int J Geriatr Psychiatry	2019	a anemia blood transfusion delirium elective orthopedic surgery
Vitamin D levels and risk of delirium: A mendelian randomization study in the UK Biobank	Bowman, K. Jones, L. Pilling, L. C. Delgado, J. Kuchel, G. A. Ferrucci, L. Fortinsky, R. H. Melzer, D.	Neurology	2019
Pharmacological interventions for prevention and management of delirium in intensive care patients: A systematic overview of reviews and meta-analyses.	Barbateskovic, M. Krauss, S. R. Collet, M. O. Larsen, L. K. Jakobsen, J. C. Perner, A. Wetterslev, J.	BMJ Open	2019	CRD42016046628 cholinesterase inhibitor neuroleptic agent opiate all cause mortality cognition delirium human intensive care unit meta analysis quality of life review systematic review unspecified side effect
Pre-operative biomarkers and imaging tests as predictors of post-operative delirium in non-cardiac surgical patients: a systematic review.	Ayob, F. Lam, E. Ho, G. Chung, F. El-Beheiry, H. Wong, J.	BMC Anesthesiology	2019	Post-operative delirium Predicting post-operative delirium Predictive biomarkers and imaging Predictive tests Systematic review
Training interventions to improve general hospital care for older people with cognitive impairment: systematic review.	Abley, C. Dickinson, C. Andrews, Z. Prato, L. Lindley, L. Robinson, L.	Br J Psychiatry	2019	Dementia delirium education and training older people
Cognitive impairment and postoperative outcomes in patients undergoing primary total hip arthroplasty: A systematic review.	Viramontes, O. Luan Erfe, B. M. Erfe, J. M. Brovman, E. Y. Boehme, J. Bader, A. M. Urman, R. D.	J Clin Anesth	2019	Anesthesia Cognitive impairment Delirium Dementia Outcomes Surgery
Autonomic cardiovascular control in older patients with acute infection and delirium: a pilot study of orthostatic stress responses.	Neerland, B. E. Wyller, T. B. Wyller, V. B. B.	BMC Geriatr	2019	Autonomic function Delirium Head-up tilt Heart rate variability
The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy - A prospective, pilot observational study.	Ehler, J. Petzold, A. Wittstock, M. Kolbaske, S. Gloger, M. Henschel, J. Heslegrave, A. Zetterberg, H. Lunn, M. P. Rommer, P. S. Grossmann, A. Sharshar, T. Richter, G. Noldge-Schomburg, G. Sauer, M.	PLoS One	2019
A systematic review of interventions to facilitate extubation in patients difficult-to-wean due to delirium, agitation, or anxiety and a meta-analysis of the effect of dexmedetomidine.	Dupuis, S. Brindamour, D. Karzon, S. Frenette, A. J. Charbonney, E. Perreault, M. M. Bellemare, P. Burry, L. Williamson, D. R.	Can J Anaesth	2019
Haloperidol for the management of delirium in adult intensive care unit patients: A systematic review and meta-analysis of randomized controlled trials.	Zayed, Y. Barbarawi, M. Kheiri, B. Banifadel, M. Haykal, T. Chahine, A. Rashdan, L. Aburahma, A. Bachuwa, G. Seedahmed, E.	J Crit Care	2019	Critically ill patients Delirium Haloperidol Icu Meta-analysis
Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study.	Westphal, S. Stoppe, C. Gruenewald, M. Bein, B. Renner, J. Cremer, J. Coburn, M. Schaelte, G. Boening, A. Niemann, B. Kletzin, F. Roesner, J. Strouhal, U. Reyher, C. Laufenberg-Feldmann, R. Ferner, M. Brandes, I. F. Bauer, M. Kortgen, A. Stehr, S. N. Witt	BMC Cardiovasc Disord	2019	Acute kidney injury Atrial fibrillation Cardiac surgery Delirium Genome-wide association study Myocardial infarction Stroke
Preoperative Anxiety as a Predictor of Delirium in Cancer Patients: A Prospective Observational Cohort Study.	Wada, S. Inoguchi, H. Sadahiro, R. Matsuoka, Y. J. Uchitomi, Y. Sato, T. Shimada, K. Yoshimoto, S. Daiko, H. Shimizu, K.	World J Surg	2019
Development of a Dynamic Multi-Protein Signature of Postoperative Delirium.	Vasunilashorn, S. M. Ngo, L. H. Chan, N. Y. Zhou, W. Dillon, S. T. Otu, H. H. Inouye, S. K. Wyrobnik, I. Kuchel, G. A. McElhaney, J. E. Xie, Z. Alsop, D. C. Jones, R. N. Libermann, T. A. Marcantonio, E. R.	J Gerontol A Biol Sci Med Sci	2019
Improved Guideline Adherence and Reduced Brain Dysfunction After a Multicenter Multifaceted Implementation of ICU Delirium Guidelines in 3,930 Patients.	Trogrlic, Z. van der Jagt, M. Lingsma, H. Gommers, D. Ponssen, H. H. Schoonderbeek, J. F. J. Schreiner, F. Verbrugge, S. J. Duran, S. Bakker, J. Ista, E.	Crit Care Med	2019
Trajectory of severity of postoperative delirium symptoms and its prospective association with cognitive function in patients with gastric cancer: results from a prospective observational study.	Shim, E. J. Noh, H. L. Lee, K. M. Hwang, H. Son, K. L. Jung, D. Kim, W. H. Kong, S. H. Suh, Y. S. Lee, H. J. Yang, H. K. Hahm, B. J.	Support Care Cancer	2019	Anesthesia Cognitive function Delirium Gastrectomy Gastric cancer
Sedation Variability Increases Incidence of Delirium in Adult Medical Intensive Care Unit Patients at a Tertiary Academic Medical Center.	Ritchie, B. M. Torbic, H. DeGrado, J. R. Reardon, D. P.	Am J Ther	2019
Current Pharmacotherapy Does Not Improve Severity of Hypoactive Delirium in Patients with Advanced Cancer: Pharmacological Audit Study of Safety and Efficacy in Real World (Phase-R).	Okuyama, T. Yoshiuchi, K. Ogawa, A. Iwase, S. Yokomichi, N. Sakashita, A. Tagami, K. Uemura, K. Nakahara, R. Akechi, T.	Oncologist	2019	Antipsychotic agents Delirium Neoplasms Palliative care Pharmacovigilance article.
Quality of care in hospitalized cancer patients before and after implementation of a systematic prevention program for delirium: the DELTA exploratory trial.	Ogawa, A. Okumura, Y. Fujisawa, D. Takei, H. Sasaki, C. Hirai, K. Kanno, Y. Higa, K. Ichida, Y. Sekimoto, A. Asanuma, C.	Supportive Care in Cancer	2019	benzodiazepine derivative neuroleptic agent adolescent adult aged article cancer patient child cohort analysis daily life activity delirium extubation female health care quality health program high risk population hospital discharge human independence infant length of stay major clinical study male malignant neoplasm newborn prescription priority journal retrospective study risk factor self concept
Relevance of peripheral cholinesterase activity on postoperative delirium in adult surgical patients (CESARO): A prospective observational cohort study.	Müller, A. Olbert, M. Heymann, A. Zahn, P. K. Plaschke, K. von Dossow, V. Bitzinger, D. Barth, E. Meister, M. Kranke, P. Herrmann, C. Wernecke, K. D. Spies, C. D.	European Journal of Anaesthesiology	2019	NCT01964274 adult article cohort analysis controlled study elective surgery enzyme activity female hospital patient human major clinical study male middle aged multicenter study multivariate logistic regression analysis nursing observational study perioperative period postoperative delirium postoperative period preoperative evaluation prospective study protein function regulatory mechanism risk assessment surgery surgical patient acetylcholinesterase cholinesterase endogenous compound hemoglobin
Predicting postoperative delirium and postoperative cognitive decline with combined intraoperative electroencephalogram monitoring and cerebral near-infrared spectroscopy in patients undergoing cardiac interventions.	Momeni, M. Meyer, S. Docquier, M. A. Lemaire, G. Kahn, D. Khalifa, C. Rosal Martins, M. Van Dyck, M. Jacquet, L. M. Peeters, A. Watremez, C.	J Clin Monit Comput	2019	Burst suppression Cerebral oximetry Depth-of-anesthesia monitor Postoperative cognitive decline Postoperative delirium
Early Postoperative Actigraphy Poorly Predicts Hypoactive Delirium.	Maybrier, H. R. King, C. R. Crawford, A. E. Mickle, A. M. Emmert, D. A. Wildes, T. S. Avidan, M. S. Palanca, B. J. A.	J Clin Sleep Med	2019	actigraphy anesthesia arousal postoperative delirium sleep surgery
Subsyndromal delirium is associated with poor functional outcome after ischemic stroke.	Klimiec, E. Lis, A. Pera, J. Slowik, A. Dziedzic, T.	Eur J Neurol	2019	confusion delirium outcome stroke subsyndromal delirium
Pharmacological Management of Delirium in the Intensive Care Unit: A Randomized Pragmatic Clinical Trial.	Khan, B. A. Perkins, A. J. Campbell, N. L. Gao, S. Farber, M. O. Wang, S. Khan, S. H. Zarzaur, B. L. Boustani, M. A.	J Am Geriatr Soc	2019	benzodiazepine delirium haloperidol randomized trial
Use of medicines that may precipitate delirium prior to hospitalisation in older Australians with delirium: An observational study.	Kassie, G. M. Kalisch Ellett, L. M. Nguyen, T. A. Roughead, E. E.	Australas J Ageing	2019	delirium drug utilization inappropriate prescribing medication review older patients
Comprehensive risk factor evaluation of postoperative delirium following major surgery: clinical data warehouse analysis.	Kang, S. Y. Seo, S. W. Kim, J. Y.	Neurol Sci	2019	Clinical data warehouse Delirium Operation Parkinsonism Risk factor Type of surgery
Lower risk of postoperative delirium using laparoscopic approach for major abdominal surgery.	Ito, K. Suka, Y. Nagai, M. Kawasaki, K. Yamamoto, M. Koike, D. Nomura, Y. Tanaka, N. Kawaguchi, Y.	Surg Endosc	2019	Laparoscopic approach Major abdominal surgery Open approach Postoperative delirium
Delirium is associated with frequency band specific dysconnectivity in intrinsic connectivity networks: preliminary evidence from a large retrospective pilot case-control study.	Fleischmann, R. Traenkner, S. Kraft, A. Schmidt, S. Schreiber, S. J. Brandt, S. A.	Pilot Feasibility Stud	2019	Biomarker Delirium Oscillatory activity Source analysis electroencephalography accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. As a retrospective study in Germany, a separate approval is waived.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Risk Factors Associated With Postoperative Delirium in Patients Undergoing Head and Neck Free Flap Reconstruction.	Densky, J. Eskander, A. Kang, S. Chan, J. Tweel, B. Sitapara, J. Ozer, E. Agrawal, A. Carrau, R. Rocco, J. Teknos, T. N. Old, M.	JAMA Otolaryngol Head Neck Surg	2019
Deprescribing in the Pharmacologic Management of Delirium: A Randomized Trial in the Intensive Care Unit.	Campbell, N. L. Perkins, A. J. Khan, B. A. Gao, S. Farber, M. O. Khan, S. Wang, S. Boustani, M. A.	J Am Geriatr Soc	2019	anticholinergic benzodiazepine delirium deprescribing
Reliability of mobility measures in older medical patients with cognitive impairment.	Braun, T. Thiel, C. Schulz, R. J. Gruneberg, C.	BMC Geriatr	2019	Cognitive impairment Dementia Limits of agreement Measurement error Minimal detectable change Mobility limitation Older people Outcome measure Reliability
Effectiveness of Melatonin for the Prevention of Intensive Care Unit Delirium.	Baumgartner, L. Lam, K. Lai, J. Barnett, M. Thompson, A. Gross, K. Morris, A.	Pharmacotherapy	2019	Delirium intensive-care unit melatonin sleep
Validation of the Prediction of Delirium for Intensive Care model to predict subsyndromal delirium.	Azuma, K. Mishima, S. Shimoyama, K. Ishii, Y. Ueda, Y. Sakurai, M. Morinaga, K. Fujikawa, T. Oda, J.	Acute Med Surg	2019	Critical care delirium intensive care unit psychiatry sleep
Association Between Postoperative Delirium and Long-term Cognitive Function After Major Nonemergent Surgery.	Austin, C. A. O'Gorman, T. Stern, E. Emmett, D. Sturmer, T. Carson, S. Busby-Whitehead, J.	JAMA Surg	2019
'I hope you get normal again': an explorative study on how delirious octogenarian patients experience their interactions with healthcare professionals and relatives after aortic valve therapy.	Instenes, I. Fridlund, B. Amofah, H. A. Ranhoff, A. H. Eide, L. S. Norekval, T. M.	Eur J Cardiovasc Nurs	2018	Delirium octogenarian patients qualitative research surgical aortic valve replacement transcatheter aortic valve replacement
Establishing a successful perioperative geriatric service in an Australian acute surgical unit.	Styan, L. Murphy, S. Fleury, A. McGowan, B. Wullschleger, M.	ANZ Journal of Surgery	2018	aged article cohort analysis complication controlled study delirium female general surgery hospital mortality human length of stay male medical record review morbidity peroperative complication retrospective study surgery
Delirium and Antipsychotic Medications at Hospital Intake: Screening to Decrease Likelihood of Aggression in Inpatient Settings Among Unknown Patients With Dementia.	Wharton, T. Paulson, D. Burcher, K. Lesch, H.	Am J Alzheimers Dis Other Demen	2018	behavior delirium medication screening
Preoperative assessment of frailty predicts age-related events after hepatic resection: a prospective multicenter study.	Tanaka, S. Ueno, M. Iida, H. Kaibori, M. Nomi, T. Hirokawa, F. Ikoma, H. Nakai, T. Eguchi, H. Kubo, S.	J Hepatobiliary Pancreat Sci	2018	Age Factors Aged Aged, 80 and over Comorbidity Female Frailty/diagnosis Geriatric Assessment Hepatectomy/adverse effects Humans Liver Diseases/surgery Liver Neoplasms/surgery Male Preoperative Period Prospective Studies Risk Factors Delirium Dependency Kihon Checklist Phenotypic frail index Transfer
Efficacy and Tolerability of Atypical Antipsychotics in the Treatment of Delirium: A Systematic Review of the Literature.	Rivière, J. van der Mast, R. C. Vandenberghe, J. Van Den Eede, F.	Psychosomatics	2018	aged article comparative study controlled study delirium drug combination drug therapy extrapyramidal symptom female human incidence male Medline meta analysis open study randomized controlled trial (topic) sedation systematic review amisulpride aripiprazole asenapine clozapine haloperidol iloperidone lurasidone olanzapine paliperidone perospirone placebo quetiapine risperidone sertindole ziprasidone zotepine
Outcomes of Prehospital Chemical Sedation With Ketamine Versus Haloperidol and Benzodiazepine or Physical Restraint Only.	O'Connor, L. Rebesco, M. Robinson, C. Gross, K. Castellana, A. O'Connor, M. J. Restuccia, M.	Preshosp Emerg Care	2018	agitated delirium ketamine restraint sedation
Just another piece of paperwork": perceptions of clinicians on delirium screening following hip fracture repair elicited in focus groups.	Oberai, T. Killington, M. Laver, K. Crotty, M. Jaarsma, R.	Int Psychogeriatr	2018	aging cognitive impairment delirium qualitative research
Altered mental status predicts mortality in cardiogenic shock – results from the CardShock study.	Kataja, A. Tarvasmäki, T. Lassus, J. Køber, L. Sionis, A. Spinar, J. Parissis, J. Carubelli, V. Cardoso, J. Banaszewski, M. Marino, R. Nieminen, M. S. Mebazaa, A. Harjola, V. P.	European Heart Journal: Acute Cardiovascular Care	2018	NCT01374867 adult aged arterial pH article cardiogenic shock cardiovascular mortality clinical assessment female heart left ventricle ejection fraction human lactate blood level major clinical study male mental health multicenter study observational study prevalence priority journal prospective study systolic blood pressure
Nurses' and physicians' approaches to delirium management in the intensive care unit: A focus group investigation.	Collet, M. O. Thomsen, T. Egerod, I.	Aust Crit Care	2018	Delirium Focus groups Hermeneutics Intensive care unit Nursing care Pharmacological action Qualitative research
Low Plasma Cholinesterase Activity is Associated With Postoperative Delirium After Noncardiac Surgery in Elderly Patients: A Prospective Observational Study.	Zhao, B. Ni, Y. Tian, X.	Psychosomatics	2018	aged alcohol consumption APACHE article cholinesterase blood level cohort analysis comorbidity confounding variable controlled study enzyme activity female Han Chinese human human tissue incidence major clinical study male multivariate logistic regression analysis observational study postoperative delirium prospective study risk factor surgery surgical intensive care unit acetylcholinesterase biological marker cholinesterase endogenous compound
Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults.	Zhang, Y. Shan, G. J. Zhang, Y. X. Cao, S. J. Zhu, S. N. Li, H. J. Ma, D. Wang, D. X.	British Journal of Anaesthesia	2018	ChiCTR-IPR-15006209 NCT02662257 propofol sevoflurane aged anesthetic recovery APACHE article bispectral index bradycardia bronchospasm cancer surgery cognition comparative study controlled study delayed neurocognitive recovery electrocardiogram emergence agitation end tidal carbon dioxide tension female general anesthesia heart ventricle extrasystole human hypertension hypotension intraoperative monitoring major clinical study male multicenter study neuropsychological test oxygen saturation patient safety perioperative period postoperative cognitive dysfunction postoperative nausea and vomiting priority journal randomized controlled trial tachycardia very elderly
Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery.	Xie, S. Xie, M.	Pak J Pharm Sci	2018