What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients
- Authors
- Olsen, H. T. Nedergaard, H. K. Strøm, T. Oxlund, J. Wian, K. A. Ytrebø, L. M. Kroken, B. A. Chew, M. Korkmaz, S. Lauridsen, J. T. Toft, P.
- Year
- 2020
- Journal
- The New England journal of medicine
- Abstract
BACKGROUND: In critically ill, mechanically ventilated patients, daily interruption of sedation has been shown to reduce the time on ventilation and the length of stay in the intensive care unit (ICU). Data on whether a plan of no sedation, as compared with a plan of light sedation, has an effect on mortality are lacking. METHODS: In a multicenter, randomized, controlled trial, we assigned, in a 1:1 ratio, mechanically ventilated ICU patients to a plan of no sedation (nonsedation group) or to a plan of light sedation (i.e., to a level at which the patient was arousable, defined as a score of -2 to -3 on the Richmond Agitation and Sedation Scale [RASS], on which scores range from -5 [unresponsive] to +4 [combative]) (sedation group) with daily interruption. The primary outcome was mortality at 90 days. Secondary outcomes were the number of major thromboembolic events, the number of days free from coma or delirium, acute kidney injury according to severity, the number of ICU-free days, and the number of ventilator-free days. Between-group differences were calculated as the value in the nonsedation group minus the value in the sedation group. RESULTS: A total of 710 patients underwent randomization, and 700 were included in the modified intention-to-treat analysis. The characteristics of the patients at baseline were similar in the two trial groups, except for the score on the Acute Physiology and Chronic Health Evaluation (APACHE) II, which was 1 point higher in the nonsedation group than in the sedation group, indicating a greater chance of in-hospital death. The mean RASS score in the nonsedation group increased from -1.3 on day 1 to -0.8 on day 7 and, in the sedation group, from -2.3 on day 1 to -1.8 on day 7. Mortality at 90 days was 42.4% in the nonsedation group and 37.0% in the sedated group (difference, 5.4 percentage points; 95% confidence interval [CI], -2.2 to 12.2; P = 0.65). The number of ICU-free days and of ventilator-free days did not differ significantly between the trial groups. The patients in the nonsedation group had a median of 27 days free from coma or delirium, and those in the sedation group had a median of 26 days free from coma or delirium. A major thromboembolic event occurred in 1 patient (0.3%) in the nonsedation group and in 10 patients (2.8%) in the sedation group (difference, -2.5 percentage points; 95% CI, -4.8 to -0.7 [unadjusted for multiple comparisons]). CONCLUSIONS: Among mechanically ventilated ICU patients, mortality at 90 days did not differ significantly between those assigned to a plan of no sedation and those assigned to a plan of light sedation with daily interruption. (Funded by the Danish Medical Research Council and others; NONSEDA ClinicalTrials.gov number, NCT01967680.).
- PMID
- Keywords
NCT01967680
acute kidney failure
adult
agitation
APACHE
article
artificial ventilation
coma
controlled study
critically ill patient
delirium
female
human
intensive care unit
major clinical study
male
medical research
mortality
multicenter study
outcome assessment
randomization
randomized controlled trial
sedation
thromboembolism
ventilated patient
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Preoperative assessment of frailty predicts age-related events after hepatic resection: a prospective multicenter study. | Tanaka, S. Ueno, M. Iida, H. Kaibori, M. Nomi, T. Hirokawa, F. Ikoma, H. Nakai, T. Eguchi, H. Kubo, S. | J Hepatobiliary Pancreat Sci | 2018 |
Age Factors |
| Efficacy and Tolerability of Atypical Antipsychotics in the Treatment of Delirium: A Systematic Review of the Literature. | Rivière, J. van der Mast, R. C. Vandenberghe, J. Van Den Eede, F. | Psychosomatics | 2018 |
aged |
| Outcomes of Prehospital Chemical Sedation With Ketamine Versus Haloperidol and Benzodiazepine or Physical Restraint Only. | O'Connor, L. Rebesco, M. Robinson, C. Gross, K. Castellana, A. O'Connor, M. J. Restuccia, M. | Preshosp Emerg Care | 2018 |
agitated delirium |
| Just another piece of paperwork": perceptions of clinicians on delirium screening following hip fracture repair elicited in focus groups. | Oberai, T. Killington, M. Laver, K. Crotty, M. Jaarsma, R. | Int Psychogeriatr | 2018 |
aging |
| Altered mental status predicts mortality in cardiogenic shock – results from the CardShock study. | Kataja, A. Tarvasmäki, T. Lassus, J. Køber, L. Sionis, A. Spinar, J. Parissis, J. Carubelli, V. Cardoso, J. Banaszewski, M. Marino, R. Nieminen, M. S. Mebazaa, A. Harjola, V. P. | European Heart Journal: Acute Cardiovascular Care | 2018 |
NCT01374867 |
| Nurses' and physicians' approaches to delirium management in the intensive care unit: A focus group investigation. | Collet, M. O. Thomsen, T. Egerod, I. | Aust Crit Care | 2018 |
Delirium |
| Low Plasma Cholinesterase Activity is Associated With Postoperative Delirium After Noncardiac Surgery in Elderly Patients: A Prospective Observational Study. | Zhao, B. Ni, Y. Tian, X. | Psychosomatics | 2018 |
aged |
| Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults. | Zhang, Y. Shan, G. J. Zhang, Y. X. Cao, S. J. Zhu, S. N. Li, H. J. Ma, D. Wang, D. X. | British Journal of Anaesthesia | 2018 |
ChiCTR-IPR-15006209 |
| Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery. | Xie, S. Xie, M. | Pak J Pharm Sci | 2018 | |
| Development and Validation of an Electronic Health Record-Based Machine Learning Model to Estimate Delirium Risk in Newly Hospitalized Patients Without Known Cognitive Impairment. | Wong, A. Young, A. T. Liang, A. S. Gonzales, R. Douglas, V. C. Hadley, D. | JAMA Netw Open | 2018 | |
| Sedative drugs used for mechanically ventilated patients in intensive care units: a systematic review and network meta-analysis. | Wang, H. Wang, C. Wang, Y. Tong, H. Feng, Y. Li, M. Jia, L. Yu, K. | Curr Med Res Opin | 2018 |
Sedative drugs |
| Prediction of length of hospital stay and mortality in patients with delirium: A prospective cohort analysis of 200 ICU patients. | Tian, J. Chen, X. Liu, D. | Journal of Biological Regulators and Homeostatic Agents | 2018 |
adult |
| Ramelteon is Not Associated With Improved Outcomes Among Critically Ill Delirious Patients: A Single-Center Retrospective Cohort Study. | Thom, R. Bui, M. Rosner, B. Teslyar, P. Levy-Carrick, N. Wolfe, D. Klompas, M. | Psychosomatics | 2018 |
Delirium |
| A daily multidisciplinary assessment of older adults undergoing elective colorectal cancer surgery is associated with reduced delirium and geriatric syndromes. | Tarazona-Santabalbina, F. J. Llabata-Broseta, J. Belenguer-Varea, A. Alvarez-Martinez, D. Cuesta-Peredo, D. Avellana-Zaragoza, J. A. | J Geriatr Oncol | 2018 |
Colorectal surgery |
| Preventive Effect of Suvorexant for Postoperative Delirium after Coronary Artery Bypass Grafting. | Tamura, K. Maruyama, T. Sakurai, S. | Ann Thorac Cardiovasc Surg | 2018 |
Suvorexant |
| Aproach to the risk of delirium in an orthogeriatric unit. | Sopena Bert, E. Qanneta, R. Valenti Moreno, V. San Jose Laporte, A. | Med Clin | 2018 |
Delirium |
| A systematic review of the use of music interventions to improve outcomes for patients undergoing hip or knee surgery. | Sibanda, A. Carnes, D. Visentin, D. Cleary, M. | J Adv Nurs | 2018 |
anxiety |
| Use of "Months of the Year Backwards" (MOTYB) as a Screening Tool for Delirium in Palliative Care Patients in the Acute Hospital Setting. | Ryan, S. Hayes, D. Creedon, B. | Ir Med J | 2018 | |
| Impact of psychotic symptoms on clinical outcomes in delirium. | Paik, S. H. Ahn, J. S. Min, S. Park, K. C. Kim, M. H. | PLoS ONE | 2018 |
neuroleptic agent |
| Preoperative age and prognostic nutritional index are useful factors for evaluating postoperative delirium among patients with adult spinal deformity. | Oe, S. Togawa, D. Yamato, Y. Hasegawa, T. Yoshida, G. Kobayashi, S. Yasuda, T. Banno, T. Arima, H. Mihara, Y. Ushirozako, H. Yamada, T. Matsuyama, Y. | Spine | 2018 | |
| Decreased Risk of Delirium With Use of Regional Analgesia in Geriatric Trauma Patients With Multiple Rib Fractures. | O'Connell, K. M. Quistberg, D. A. Tessler, R. Robinson, B. R. H. Cuschieri, J. Maier, R. V. Rivara, F. P. Vavilala, M. S. Bhalla, P. I. Arbabi, S. | Ann Surg | 2018 |
OBJECTIVE: The aim of this study was to examine the risk of delirium in geriatric trauma patients with rib fractures treated with systemic opioids compared with those treated with regional analgesia (RA). SUMMARY OF BACKGROUND DATA: Delirium is a modifiable complication associated with increased morbidity and mortality. RA may reduce the need for opioid medications, which are associated with delirium in older adults. METHODS: Cohort study of patients >/=65 years admitted to a regional trauma center from 2011 to 2016. Inclusion factors were >/= 3 rib fractures, blunt trauma mechanism, and admission to intensive care unit (ICU). Exclusion criteria included head AIS >/=3, spine AIS >/=3, dementia, and death within 24 hours. The primary outcome was delirium positive ICU days, defined using the CAM-ICU assessment. Delirium incident rate ratios (IRRs) and 95% confidence intervals (95% CIs) were estimated using generalized linear mixed models with Poisson distribution and robust standard errors. RESULTS: Of the 144 patients included in the study, 27 (19%) received Acute Pain Service consultation and RA and 117 (81%) received opioid-based systemic analgesia. Patients with RA had more severe chest injury than those without. The risk of delirium decreased by 24% per day per patient with use of RA (IRR 0.76, 95% CI 0.61 to 0.96). Individual opioid use, as measured in daily morphine equivalents (MEDs), was significantly reduced after initiation of RA (mean difference -7.62, 95% CI -14.4 to -0.81). CONCLUSION: Although use of RA techniques in geriatric trauma patients with multiple rib fractures was associated with higher MED, opioid use decreased after RA initiation and Acute Pain Service consultation, and the risk of delirium was lower. |
| Hypotension and a positive fluid balance are associated with delirium in patients with shock. | Nguyen, D. N. Huyghens, L. Parra, J. Schiettecatte, J. Smitz, J. Vincent, J. L. | PLoS One | 2018 | |
| End-Tidal Hypocapnia Under Anesthesia Predicts Postoperative Delirium. | Mutch, W. A. C. El-Gabalawy, R. Girling, L. Kilborn, K. Jacobsohn, E. | Front Neurol | 2018 |
*anesthetic agent |
| Risk Factors for Delirium after Spine Surgery: An Age-Matched Analysis. | Morino, T. Hino, M. Yamaoka, S. Misaki, H. Ogata, T. Imai, H. Miura, H. | Asian Spine J | 2018 |
Delirium |
| Outcomes of Patients With Delirium in Long-Term Care Facilities: A Prospective Cohort Study. | Moon, K. J. Park, H. | J Gerontol Nurs | 2018 |
Aged |
| Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery. | Miller, D. Lewis, S. R. Pritchard, M. W. Schofield-Robinson, O. J. Shelton, C. L. Alderson, P. Smith, A. F. | Cochrane Database of Systematic Reviews | 2018 |
Aged |
| Incidence, risk factors and clinical impact of postoperative delirium following open reduction and internal fixation (ORIF) for hip fractures: an analysis of 7859 patients from the ACS-NSQIP hip fracture procedure targeted database. | Malik, A. T. Quatman, C. E. Phieffer, L. S. Ly, T. V. Khan, S. N. | Eur J Orthop Surg Traumatol | 2018 |
Delirium |
| Delirium After Cardiac Surgery and Cumulative Fluid Balance: A Case-Control Cohort Study. | Mailhot, T. Cossette, S. Lambert, J. Beaubien-Souligny, W. Cournoyer, A. O'Meara, E. Maheu-Cadotte, M. A. Fontaine, G. Bouchard, J. Lamarche, Y. Benkreira, A. Rochon, A. Denault, A. | J Cardiothorac Vasc Anesth | 2019 |
cardiac surgery |
| The point-of-care EEG for delirium detection in the emergency department. | Lee, S. Yuki, K. Chan, A. Cromwell, J. Shinozaki, G. | Am J Emerg Med | 2018 |
Bispectral EEG |
| Intraoperative hypotension is not associated with postoperative cognitive dysfunction in elderly patients undergoing general anesthesia for surgery: results of a randomized controlled pilot trial. | Langer, T. Santini, A. Zadek, F. Chiodi, M. Pugni, P. Cordolcini, V. Bonanomi, B. Rosini, F. Marcucci, M. Valenza, F. Marenghi, C. Inglese, S. Pesenti, A. Gattinoni, L. | J Clin Anesth | 2019 |
Anesthesia, general |
| Differences in healthcare outcomes between teaching and non teaching hospitals for patients with delirium: a retrospective cohort study. | Kotwal, S. Abougergi, M. S. Wright, S. | Int J Qual Health Care | 2018 | |
| Gender differences in the use of atypical antipsychotic medications for ICU delirium. | Karamchandani, K. Schoaps, R. S. Printz, J. Kowaleski, J. M. Carr, Z. J. | Crit Care | 2018 | |
| Whole-Genome mRNA Gene Expression Differs Between Patients With and Without Delirium. | Kalantar, K. LaHue, S. C. DeRisi, J. L. Sample, H. A. Contag, C. A. Josephson, S. A. Wilson, M. R. Douglas, V. C. | Journal of Geriatric Psychiatry and Neurology | 2018 |
integrin |
| Incidence and risk factors of subsyndromal delirium after curative resection of gastric cancer. | Hwang, H. Lee, K. M. Son, K. L. Jung, D. Kim, W. H. Lee, J. Y. Kong, S. H. Suh, Y. S. Lee, H. J. Yang, H. K. Hahm, B. J. | BMC Cancer | 2018 |
adult |
| Performance of Electronic Prediction Rules for Prevalent Delirium at Hospital Admission. | Halladay, C. W. Sillner, A. Y. Rudolph, J. L. | JAMA Netw Open | 2018 | |
| Harmonization of delirium severity instruments: a comparison of the DRS-R-98, MDAS, and CAM-S using item response theory. | Gross, A. L. Tommet, D. D'Aquila, M. Schmitt, E. Marcantonio, E. R. Helfand, B. Inouye, S. K. Jones, R. N. | BMC Med Res Methodol | 2018 |
Delirium |
| Prognostic factors of inhospital death in elderly patients: A time-to-event analysis of a cohort study in Martinique (French West Indies). | Godaert, L. Bartholet, S. Dorléans, F. Najioullah, F. Colas, S. Fanon, J. L. Cabié, A. Césaire, R. Dramé, M. | BMJ Open | 2018 |
aged |
| The Critical Vital Sign of Cognitive Health and Delirium: Whose Responsibility Is It? | Fick, D. M. | J Gerontol Nurs | 2018 | |
| Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. | Devlin, J. W. Skrobik, Y. Gelinas, C. Needham, D. M. Slooter, A. J. C. Pandharipande, P. P. Watson, P. L. Weinhouse, G. L. Nunnally, M. E. Rochwerg, B. Balas, M. C. van den Boogaard, M. Bosma, K. J. Brummel, N. E. Chanques, G. Denehy, L. Drouot, X. Fraser | Crit Care Med | 2018 | |
| Delirium etiology subtypes and their effect on six-month function and cognition in older emergency department patients. | Cirbus, J. MacLullich, A. M. J. Noel, C. Ely, E. W. Chandrasekhar, R. Han, J. H. | International Psychogeriatrics | 2018 |
aged |
| Perioperative Sedation in Mechanically Ventilated Cardiac Surgery Patients With Dexmedetomidine-Based Versus Propofol-Based Regimens. | Chuich, T. Cropsey, C. L. Shi, Y. Johnson, D. Shotwell, M. S. Henson, C. P. | Ann Pharmacother | 2019 |
anesthesia |
| Hospital discharge data under-reports delirium occurrence. Results from a point prevalence survey of delirium in a major Australian health service. | Casey, P. Cross, W. Webb-St Mart, M. Baldwin, C. Riddell, K. Darzins, P. | Intern Med J | 2018 |
Adult |
| TIME to think about delirium: improving detection and management on the acute medical unit. | Bauernfreund, Y. Butler, M. Ragavan, S. Sampson, E. L. | BMJ Open Qual | 2018 |
Pdsa |
| The Association of Delirium with Perioperative Complications in Primary Elective Total Hip Arthroplasty. | Aziz, K. T. Best, M. J. Naseer, Z. Skolasky, R. L. Ponnusamy, K. E. Sterling, R. S. Khanuja, H. S. | Clin Orthop Surg | 2018 |
Aged |
| Bispectral Index Monitoring During Anesthesia Promotes Early Postoperative Recovery of Cognitive Function and Reduces Acute Delirium in Elderly Patients with Colon Carcinoma: A Prospective Controlled Study using the Attention Network Test. | Zhou, Y. Li, Y. Wang, K. | Med Sci Monit | 2018 |
Aged |
| Military Service Members and Emergence Delirium Screening: An Evidence-Based Practice Project. | Wheat, L. L., 2nd Turner, B. S. Diaz, A. Maani, C. V. | J Perianesth Nurs | 2018 |
emergence delirium |
| Can delirium research activity impact on routine delirium recognition? A prospective cohort study. | Welch, C. Jackson, T. A. | BMJ Open | 2018 |
dementia |
| Preoperative STOP-BANG Scores and Postoperative Delirium and Coma in Thoracic Surgery Patients. | Wang, S. Sigua, N. L. Manchanda, S. Gradney, S. Khan, S. H. Perkins, A. Kesler, K. Khan, B. | Ann Thorac Surg | 2018 | |
| The Cost of ICU Delirium and Coma in the Intensive Care Unit Patient. | Vasilevskis, E. E. Chandrasekhar, R. Holtze, C. H. Graves, J. Speroff, T. Girard, T. D. Patel, M. B. Hughes, C. G. Cao, A. Pandharipande, P. P. Ely, E. W. | Med Care | 2018 | |
| Pharmacologic prevention of postoperative delirium after on-pump cardiac surgery: A meta-analysis of randomized trials. | Tao, R. Wang, X. W. Pang, L. J. Cheng, J. Wang, Y. M. Gao, G. Q. Liu, Y. Wang, C. | Medicine | 2018 |
Antipsychotic Agents/*therapeutic use |
| Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging. | Shinozaki, G. Braun, P. R. Hing, B. W. Q. Ratanatharathorn, A. Klisares, M. J. Duncan, G. N. Jellison, S. S. Heinzman, J. T. Nagahama, Y. Close, L. Sabbagh, S. Dlouhy, B. J. Howard, M. A. Kawasaki, H. Cho, H. R. | Front Aging Neurosci | 2018 |
DNA methylation |
| The Hospital Elder Life Program: Past and Future. | Scheunemann, L. P. Girard, T. D. Skidmore, E. R. Resnick, N. M. | Am J Geriatr Psychiatry | 2018 | |
| Delirium in the Acute Phase of Ischemic Stroke: Incidence, Risk Factors, and Effects on Functional Outcome. | Qu, J. Chen, Y. Luo, G. Zhong, H. Xiao, W. Yin, H. | J Stroke Cerebrovasc Dis | 2018 |
Activities of Daily Living |
| Effect of dynamic light at the coronary care unit on the length of hospital stay and development of delirium: A retrospective cohort study. | Pustjens, T. Schoutens, A. M. C. Janssen, L. Heesen, W. F. | Journal of Geriatric Cardiology | 2018 |
neuroleptic agent |
| Frailty and Delirium in Older Adults: A Systematic Review and Meta-Analysis of the Literature. | Persico, I. Cesari, M. Morandi, A. Haas, J. Mazzola, P. Zambon, A. Annoni, G. Bellelli, G. | J Am Geriatr Soc | 2018 |
cognition |
| Medications and Patient Characteristics Associated With Falling in the Hospital. | OʼNeil, C. A. Krauss, M. J. Bettale, J. Kessels, A. Costantinou, E. Dunagan, W. C. Fraser, V. J. | Journal of Patient Safety | 2018 |
adult |
| Delirium detection using relative delta power based on 1-minute single-channel EEG: a multicentre study. | Numan, T. van den Boogaard, M. Kamper, A. M. Rood, P. J. T. Peelen, L. M. Slooter, A. J. C. | Br J Anaesth | 2018 |
complications, postoperative |
| Low skeletal muscle mass as a risk factor for postoperative delirium in elderly patients undergoing colorectal cancer surgery. | Mosk, C. A. L. A. van Vugt J de Jonge, H. Witjes, C. D. Buettner, S. Ijzermans, J. N. van der Laan, L. | Clin Interv Aging | 2018 |
Aged |
| Symptom expression in advanced cancer patients admitted to hospice or home care with and without delirium. | Mercadante, S. Masedu, F. Maltoni, M. De Giovanni, D. Montanari, L. Pittureri, C. Berte, R. Russo, D. Ursini, L. Marinangeli, F. Aielli, F. | Intern Emerg Med | 2018 |
Advanced cancer |
| Symptom Expression in Patients with Advanced Cancer Admitted to an Acute Supportive/Palliative Care Unit With and Without Delirium. | Mercadante, S. Adile, C. Ferrera, P. Cortegiani, A. Casuccio, A. | Oncologist | 2018 |
Advanced cancer |
| Pain, agitation and delirium assessment and management in a community medical-surgical ICU: results from a prospective observational study and nurse survey. | Maximous, R. Miller, F. Tan, C. Camargo, M. Ross, K. Marshall, C. Yung, P. Fleming, D. Law, M. Tsang, J. L. Y. | BMJ Open Qual | 2018 |
attitudes |
| Evaluating the risk profile of quetiapine in treating delirium in the intensive care adult population: A retrospective review. | Mangan, K. C. McKinzie, B. P. Deloney, L. P. Leon, S. M. Eriksson, E. A. | J Crit Care | 2018 |
Delirium |
| Cerebral monitoring of anaesthesia on reducing cognitive dysfunction and postoperative delirium: a systematic review. | Luo, C. Zou, W. | J Int Med Res | 2018 |
Anesthesia/*adverse effects/methods |
| Dysfunctional cerebral autoregulation is associated with delirium in critically ill adults. | Lee, K. F. Wood, M. D. Maslove, D. M. Muscedere, J. G. Boyd, J. G. | J Cereb Blood Flow Metab | 2018 |
Cerebral autoregulation |
| Defining delirium in idiopathic Parkinson's disease: A systematic review. | Lawson, R. A. McDonald, C. Burn, D. J. | Parkinsonism and Related Disorders | 2018 |
adult |
| Delirium assessment in neuro-critically ill patients: A validation study. | Larsen, L. K. Frokjaer, V. G. Nielsen, J. S. Skrobik, Y. Winkler, Y. Moller, K. Petersen, M. Egerod, I. | Acta Anaesthesiol Scand | 2018 |
acute brain injury |
| Benzodiazepine Use and Neuropsychiatric Outcomes in the ICU: A Systematic Review | Kok, L. Slooter, A. J. Hillegers, M. H. van Dijk, D. Veldhuijzen, D. S. | Crit Care Med | 2018 | |
| Hospital Elder Life Program: Systematic Review and Meta-analysis of Effectiveness | Hshieh, T. T. Yang, T. Gartaganis, S. L. Yue, J. Inouye, S. K. | Am J Geriatr Psychiatry | 2018 |
Delirium prevention |
| Predictive Modeling for Geriatric Hip Fracture Patients: Early Surgery and Delirium Have the Largest Influence on Length of Stay. | Hecht, G. Slee, C. A. Goodell, P. B. Taylor, S. L. Wolinsky, P. R. | J Am Acad Orthop Surg | 2018 | |
| The Erasmus Frailty Score is associated with delirium and 1-year mortality after Transcatheter Aortic Valve Implantation in older patients. The TAVI Care & Cure program. | Goudzwaard, J. A. de Ronde-Tillmans, Mjag El Faquir, N. Acar, F. Van Mieghem, N. M. Lenzen, M. J. de Jaegere, P. P. T. Mattace-Raso, F. U. S. | Int J Cardiol | 2019 |
Delirium |
| Transcutaneous electrical acupoint stimulation for prevention of postoperative delirium in geriatric patients with silent lacunar infarction: a preliminary study. | Gao, F. Zhang, Q. Li, Y. Tai, Y. Xin, X. Wang, X. Wang, Q. | Clin Interv Aging | 2018 |
*Acupuncture Points |
| Dexmedetomidine in prevention and treatment of postoperative and intensive care unit delirium: a systematic review and meta-analysis. | Flükiger, J. Hollinger, A. Speich, B. Meier, V. Tontsch, J. Zehnder, T. Siegemund, M. | Annals of Intensive Care | 2018 |
dexmedetomidine |
| Long-term prognostic value of delirium in elderly patients with acute cardiac diseases admitted to two cardiac intensive care units: a prospective study (DELIRIUM CORDIS). | Falsini, G. Grotti, S. Porto, I. Toccafondi, G. Fraticelli, A. Angioli, P. Ducci, K. Liistro, F. Pieroni, M. Taddei, T. Romanelli, S. Rossi, R. Bolognese, L. | Eur Heart J Acute Cardiovasc Care | 2018 |
Acute Disease |
| Persistent Delirium in Elderly patients Three Months After Hospital Discharge from a University Clinic. | Constaín, G. A. Ocampo Saldarriaga, M. V. Velásquez Tirado, J. D. Rodríguez-Gázquez, M. D. L. Á Betancur Morales, L. M. Rico Escobar, J. J. Castilla Agudelo, G. A. Maya Osorno, A. F. | Revista Colombiana de Psiquiatria | 2018 |
aged |
| A Web-Based Serious Game on Delirium as an Educational Intervention for Medical Students: Randomized Controlled Trial. | Buijs-Spanjers, K. R. Hegge, H. H. Jansen, C. J. Hoogendoorn, E. de Rooij, S. E. | JMIR Serious Games | 2018 |
delirium |
| Relationship Between Near-Infrared Spectroscopy-Derived Cerebral Oxygenation and Delirium in Critically Ill Patients: A Systematic Review. | Bendahan, N. Neal, O. Ross-White, A. Muscedere, J. Boyd, J. G. | J Intensive Care Med | 2018 |
Cam-icu |
| Ability of suvorexant to prevent delirium in patients in the intensive care unit: a randomized controlled trial. | Azuma, K. Takaesu, Y. Soeda, H. Iguchi, A. Uchida, K. Ohta, S. Mishima, S. Inoue, T. Inoue, Y. Oda, J. | Acute Med Surg | 2018 |
Delirium |
| Incidence of postoperative delirium in elderly ambulatory patients: A prospective evaluation using the FAM-CAM instrument. | Aya, A. G. M. Pouchain, P. H. Thomas, H. Ripart, J. Cuvillon, P. | J Clin Anesth | 2018 |
Ambulatory surgery |
| Potential Role of Exogenous Melatonin Supplement in Delirium Prevention in Critically Ill Patients: A Double-Blind Randomized Pilot Study. | Abbasi, S. Farsaei, S. Ghasemi, D. Mansourian, M. | Iran J Pharm Res | 2018 |
Clinical trial |
| Predictive nomogram for postoperative delirium in elderly patients with a hip fracture. | Zhang, X. Tong, D. K. Ji, F. Duan, X. Z. Liu, P. Z. Qin, S. Xu, K. H. Di-li, X. T. | Injury | 2018 |
aged |
| Advances in dementia with Lewy bodies | Armstrong, M. J. | Ther Adv Neurol Disord | 2021 |
Lewy body dementia |
| Factors Influencing CAM-ICU Documentation and Inappropriate "Unable to Assess" Responses | Awan, O. M. Buhr, R. G. Kamdar, B. B. | Am J Crit Care | 2021 |
Aged, 80 and over |
| Prediction of Postictal Delirium Following Status Epilepticus in the ICU: First Insights of an Observational Cohort Study | Baumann, S. M. Semmlack, S. Hunziker, S. Kaplan, P. W. De Marchis, G. M. Rüegg, S. Marsch, S. Sutter, R. | Crit Care Med | 2021 |
Aged |
| Dementia as a predictor of morbidity and mortality in patients with delirium. | van Roessel, S. Keijsers, C. J. P. W. Romijn, M. D. M. | Maturitas | 2019 |
advance care planning |
| Factors Associated With Delirium Following Electroconvulsive Therapy: A Systematic Review. | Tsujii, T. Uchida, T. Suzuki, T. Mimura, M. Hirano, J. Uchida, H. | J Ect | 2019 | |
| Predictors of delirium after cardiac surgery in patients with sleep-disordered breathing. | Tafelmeier, M. Knapp, M. Lebek, S. Floerchinger, B. Camboni, D. Creutzenberg, M. Wittmann, S. Zeman, F. Schmid, C. Maier, L. S. Wagner, S. Arzt, M. | Eur Respir J | 2019 | |
| The trajectory of C-reactive protein serum levels in older hip fracture patients with postoperative delirium. | Slor, C. J. Witlox, J. Adamis, D. Jansen, Rwmm Houdijk, A. P. J. van Gool, W. A. de Jonghe, J. F. M. Eikelenboom, P. | Int J Geriatr Psychiatry | 2019 |
C-reactive protein |
| Risk Factors for Postoperative Delirium in Type A Aortic Dissection Patients: A Retrospective Study. | Shi, Q. Mu, X. Zhang, C. Wang, S. Hong, L. Chen, X. | Med Sci Monit | 2019 | |
| Cortical and subcortical changes in resting-state functional connectivity before and during an episode of postoperative delirium. | Oh, J. Shin, J. E. Yang, K. H. Kyeong, S. Lee, W. S. Chung, T. S. Kim, J. J. | Aust N Z J Pschiatry | 2019 |
Postoperative delirium |
| Association of COMT Val(158)Met Polymorphism With Delirium Risk and Outcomes After Traumatic Brain Injury. | Nekrosius, D. Kaminskaite, M. Jokubka, R. Pranckeviciene, A. Lideikis, K. Tamasauskas, A. Bunevicius, A. | J Neuropsychiatry Clin Neurosci | 2019 |
Delirium |
| Association of earlier extubation and postoperative delirium after coronary artery bypass grafting. | Muller Moran, H. R. Maguire, D. Maguire, D. Kowalski, S. Jacobsohn, E. Mackenzie, S. Grocott, H. Arora, R. C. | Journal of Thoracic and Cardiovascular Surgery | 2019 |
adult |
| Delirium, Dementia, and In-Hospital Mortality: The Results From the Italian Delirium Day 2016, A National Multicenter Study. | Morandi, A. Di Santo, S. G. Zambon, A. Mazzone, A. Cherubini, A. Mossello, E. Bo, M. Marengoni, A. Bianchetti, A. Cappa, S. Fimognari, F. Antonelli Incalzi, R. Gareri, P. Perticone, F. Campanini, M. Penco, I. Montorsi, M. Di Bari, M. Trabucchi, M. Bellell | J Gerontol A Biol Sci Med Sci | 2019 |
Acute hospital |
| Type D personality is a predictor of prolonged acute brain dysfunction (delirium/coma) after cardiovascular surgery. | Matsuishi, Y. Shimojo, N. Unoki, T. Sakuramoto, H. Tokunaga, C. Yoshino, Y. Hoshino, H. Ouchi, A. Kawano, S. Sakamoto, H. Hiramatsu, Y. Inoue, Y. | BMC Psychol | 2019 |
Aged |
| Delirium after primary percutaneous coronary intervention in aged individuals with acute ST-segment elevation myocardial infarction: A retrospective study. | Li, S. Zhang, X. H. Zhou, G. D. Wang, J. F. | Exp Ther Med | 2019 |
ST-segment elevation |
| Preventing Delirium Takes a Village: Systematic Review and Meta-Analysis of Delirium Preventive Models of Care. | Khan, A. Boukrina, O. Oh-Park, M. Flanagan, N. A. Singh, M. Oldham, M. | J Hosp Med | 2019 | |
| Clinical predictors of postoperative delirium, functional status, and mortality in geriatric patients undergoing non-elective surgery for hip fracture. | Harris, M. J. Brovman, E. Y. Urman, R. D. | J Clin Anesth | 2019 |
Delirium |
| Impairments in balance and mobility identify delirium in patients with comorbid dementia. | Gual, N. Richardson, S. J. Davis, D. H. J. Bellelli, G. Hasemann, W. Meagher, D. Kreisel, S. H. MacLullich, A. M. J. Cerejeira, J. Inzitari, M. Morandi, A. | Int Psychogeriatr | 2019 |
Delirium |
| Delirium motor subtypes and prognosis in hospitalized geriatric patients - A prospective observational study. | Evensen, S. Saltvedt, I. Lydersen, S. Wyller, T. B. Taraldsen, K. Sletvold, O. | J Psychosom Res | 2019 |
Dmss |
| Delirium risk in non-surgical patients: systematic review of predictive tools. | Dylan, F. Byrne, G. Mudge, A. M. | Arch Gerontol Geriatr | 2019 |
clinical prediction rule |
| Pain, Opioid Intake, and Delirium Symptoms in Adults Following Joint Replacement Surgery. | Denny, D. L. Lindseth, G. N. | West J Nurs Res | 2019 |
joint replacement surgery |