What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Pharmacological interventions for the treatment of delirium in critically ill adults
- Authors
- Burry, L. Hutton, B. Williamson, D. R. Mehta, S. Adhikari, N. K. Cheng, W. Ely, E. W. Egerod, I. Fergusson, D. A. Rose, L.
- Year
- 2019
- Journal
- Cochrane Database Syst Rev
- Abstract
BACKGROUND: Although delirium is typically an acute reversible cognitive impairment, its presence is associated with devastating impact on both short-term and long-term outcomes for critically ill patients. Advances in our understanding of the negative impact of delirium on patient outcomes have prompted trials evaluating multiple pharmacological interventions. However, considerable uncertainty surrounds the relative benefits and safety of available pharmacological interventions for this population. OBJECTIVES: Primary objective1. To assess the effects of pharmacological interventions for treatment of delirium on duration of delirium in critically ill adults with confirmed or documented high risk of deliriumSecondary objectivesTo assess the following:1. effects of pharmacological interventions on delirium-free and coma-free days; days with coma; delirium relapse; duration of mechanical ventilation; intensive care unit (ICU) and hospital length of stay; mortality; and long-term outcomes (e.g. cognitive; discharge disposition; health-related quality of life); and2. the safety of such treatments for critically ill adult patients. SEARCH METHODS: We searched the following databases from their inception date to 21 March 2019: Ovid MEDLINE(R), Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Embase Classic+Embase, and PsycINFO using the Ovid platform. We also searched the Cochrane Library on Wiley, the International Prospective Register of Systematic Reviews (PROSPERO) (http://www.crd.york.ac.uk/PROSPERO/), the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. We performed a grey literature search of relevant databases and websites using the resources listed in Grey Matters developed by the Canadian Agency for Drugs and Technologies in Health (CADTH). We also searched trial registries and abstracts from annual scientific critical care and delirium society meetings. SELECTION CRITERIA: We sought randomized controlled trials (RCTs), including quasi-RCTs, of any pharmacological (drug) for treatment of delirium in critically ill adults. The drug intervention was to be compared to another active drug treatment, placebo, or a non-pharmacological intervention (e.g. mobilization). We did not apply any restrictions in terms of drug class, dose, route of administration, or duration of delirium or drug exposure. We defined critically ill patients as those treated in an ICU of any specialty (e.g. burn, cardiac, medical, surgical, trauma) or high-dependency unit. DATA COLLECTION AND ANALYSIS: Two review authors independently identified studies from the search results; four review authors (in pairs) performed data extraction and assessed risk of bias independently. We performed data synthesis through pairwise meta-analysis and network meta-analysis (NMA). Our hypothetical network structure was designed to be analysed at the drug class level and illustrated a network diagram of ‘nodes’ (i.e. drug classes) and ‘edges’ (i.e. comparisons between different drug classes from existing trials), thus describing a treatment network of all possible comparisons between drug classes. We assessed the quality of the body of evidence according to GRADE, as very low, low, moderate, or high. MAIN RESULTS: We screened 7674 citations, from which 14 trials with 1844 participants met our inclusion criteria. Ten RCTs were placebo-controlled, and four reported comparisons of different drugs. Drugs examined in these trials were the following: antipsychotics (n = 10), alpha2 agonists (n = 3; all dexmedetomidine), statins (n = 2), opioids (n = 1; morphine), serotonin antagonists (n = 1; ondansetron), and cholinesterase (CHE) inhibitors (n = 1; rivastigmine). Only one of these trials consistently used non-pharmacological interventions that are known to improve patient outcomes in both intervention and control groups.Eleven studies (n = 1153 participants) contributed to analysis of the primary outcome. Results of the NMA showed that the intervention with the smallest ratio of means (RoM) (i.e. most preferred) compared with placebo was the alpha2 agonist dexmedetomidine (0.58; 95% credible interval (CrI) 0.26 to 1.27; surface under the cumulative ranking curve (SUCRA) 0.895; moderate-quality evidence). In order of descending SUCRA values (best to worst), the next best interventions were atypical antipsychotics (RoM 0.80, 95% CrI 0.50 to 1.11; SUCRA 0.738; moderate-quality evidence), opioids (RoM 0.88, 95% CrI 0.37 to 2.01; SUCRA 0.578; very-low quality evidence), and typical antipsychotics (RoM 0.96, 95% CrI 0.64 to1.36; SUCRA 0.468; high-quality evidence).The NMAs of multiple secondary outcomes revealed that only the alpha2 agonist dexmedetomidine was associated with a shorter duration of mechanical ventilation (RoM 0.55, 95% CrI 0.34 to 0.89; moderate-quality evidence), and the CHE inhibitor rivastigmine was associated with a longer ICU stay (RoM 2.19, 95% CrI 1.47 to 3.27; moderate-quality evidence). Adverse events often were not reported in these trials or, when reported, were rare; pair-wise analysis of QTc prolongation in seven studies did not show significant differences between antipsychotics, ondansetron, dexmedetomidine, and placebo. AUTHORS’ CONCLUSIONS: We identified trials of varying quality that examined six different drug classes for treatment of delirium in critically ill adults. We found evidence that the alpha2 agonist dexmedetomidine may shorten delirium duration, although this small effect (compared with placebo) was seen in pairwise analyses based on a single study and was not seen in the NMA results. Alpha2 agonists also ranked best for duration of mechanical ventilation and length of ICU stay, whereas the CHE inhibitor rivastigmine was associated with longer ICU stay. We found no evidence of a difference between placebo and any drug in terms of delirium-free and coma-free days, days with coma, physical restraint use, length of stay, long-term cognitive outcomes, or mortality. No studies reported delirium relapse, resolution of symptoms, or quality of life. The ten ongoing studies and the six studies awaiting classification that we identified, once published and assessed, may alter the conclusions of the review.
- PMID
- Keywords
- Page(s)
- Volume
- 9
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Cerebrospinal Fluid S100B and Alzheimer’s Disease Biomarkers in Hip Fracture Patients with Delirium. | Hov, K. R. Bolstad, N. Idland, A. V. Zetterberg, H. Blennow, K. Chaudhry, F. A. Frihagen, F. Ræder, J. Wyller, T. B. Watne, L. O. | Dementia and Geriatric Cognitive Disorders Extra | 2017 |
adult |
| Effect of various antipsychotic regimens on incidence of delirium in critically ill adults. | Hawkins, W. A. Phan, S. V. Campbell, S. L. | J Crit Care | 2017 |
Antipsychotic agents |
| 2-(18)F-fluoro-2-deoxyglucose positron emission tomography in delirium. | Haggstrom, L. R. Nelson, J. A. Wegner, E. A. Caplan, G. A. | J Cereb Blood Flow Metab | 2017 |
Aged |
| Preoperative Serum Metabolites Are Associated With Postoperative Delirium in Elderly Hip-Fracture Patients. | Guo, Y. Zhang, Y. Jia, P. Wang, W. Zhou, Q. Sun, L. Zhao, A. Zhang, X. Wang, X. Li, Y. Zhang, J. Jiang, W. | J Gerontol A Biol Sci Med Sci | 2017 |
Aged |
| Delirium and effect of circadian light in the intensive care unit: a retrospective cohort study. | Estrup, S. Kjer, C. K. W. Poulsen, L. M. Gogenur, I. Mathiesen, O. | Acta Anaesthesiol Scand | 2017 | |
| Advance Directives, Hospitalization, and Survival Among Advanced Cancer Patients with Delirium Presenting to the Emergency Department: A Prospective Study. | Elsayem, A. F. Bruera, E. Valentine, A. Warneke, C. L. Wood, G. L. Yeung, S. J. Page, V. D. Silvestre, J. Brock, P. A. Todd, K. H. | Oncologist | 2017 |
Advance directives |
| Post-operative delirium is an independent predictor of 30-day hospital readmission after spine surgery in the elderly (≥65 years old): A study of 453 consecutive elderly spine surgery patients. | Elsamadicy, A. A. Wang, T. Y. Back, A. G. Lydon, E. Reddy, G. B. Karikari, I. O. Gottfried, O. N. | Journal of Clinical Neuroscience | 2017 |
acute kidney failure |
| The Abbreviated Mental Test 4 for cognitive screening of older adults presenting to the Emergency Department. | Dyer, A. H. Briggs, R. Nabeel, S. O'Neill, D. Kennelly, S. P. | Eur J Emerg Med | 2017 | |
| A Proactive Approach to High Risk Delirium Patients Undergoing Total Joint Arthroplasty. | Duque, A. F. Post, Z. D. Orozco, F. R. Lutz, R. W. Ong, A. C. | J Arthroplasty | 2017 |
complications |
| Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients. | Culley, D. J. Flaherty, D. Fahey, M. C. Rudolph, J. L. Javedan, H. Huang, C. C. Wright, J. Bader, A. M. Hyman, B. T. Blacker, D. Crosby, G. | Anesthesiology | 2017 |
Age Factors |
| Early postoperative delirium after hemiarthroplasty in elderly patients aged over 70 years with displaced femoral neck fracture. | Choi, Y. H. Kim, D. H. Kim, T. Y. Lim, T. W. Kim, S. W. Yoo, J. H. | Clin Interv Aging | 2017 |
delirium |
| Effect of short-term exposure to ambient air particulate matter on incidence of delirium in a surgical population. | Che, L. Li, Y. Gan, C. | Sci Rep | 2017 | |
| Subsyndromal Delirium and Institutionalization Among Patients With Critical Illness. | Brummel, N. E. Boehm, L. M. Girard, T. D. Pandharipande, P. P. Jackson, J. C. Hughes, C. G. Patel, M. B. Han, J. H. Vasilevskis, E. E. Thompson, J. L. Chandrasekhar, R. Bernard, G. R. Dittus, R. S. Ely, E. W. | Am J Crit Care | 2017 | |
| Delirium in the intensive care setting: A reevaluation of the validity of the CAM-ICU and ICDSC versus the DSM-IV-TR in determining a diagnosis of delirium as part of the daily clinical routine. | Boettger, S. Nunez, D. G. Meyer, R. Richter, A. Fernandez, S. F. Rudiger, A. Schubert, M. Jenewein, J. | Palliat Support Care | 2017 |
Concurrent validity |
| Delirium in the intensive care setting and the Richmond Agitation and Sedation Scale (RASS): Drowsiness increases the risk and is subthreshold for delirium. | Boettger, S. Nunez, D. G. Meyer, R. Richter, A. Fernandez, S. F. Rudiger, A. Schubert, M. Jenewein, J. | J Psychosom Res | 2017 |
Alertness |
| Is Delirium the Cognitive Harbinger of Frailty in Older Adults? A Review about the Existing Evidence. | Bellelli, G. Moresco, R. Panina-Bordignon, P. Arosio, B. Gelfi, C. Morandi, A. Cesari, M. | Front Med | 2017 |
delirium |
| Recovery after critical illness: putting the puzzle together-a consensus of 29. | Azoulay, Elie Vincent, Jean-Louis Angus, Derek C. Arabi, Yaseen M. Brochard, Laurent Brett, Stephen J. Citerio, Giuseppe Cook, Deborah J. Curtis, Jared Randall dos Santos, Claudia C. Ely, E. Wesley Hall, Jesse Halpern, Scott D. Hart, Nicholas Hopkins, Ram | Crit Care | 2017 | |
| The efficacy of antipsychotics for prolonged delirium with renal dysfunction. | Asano, S. Kunii, Y. Hoshino, H. Osakabe, Y. Shiga, T. Itagaki, S. Miura, I. Yabe, H. | Neuropsychiatr Dis Treat | 2017 |
antipsychotic |
| Comparison of the effect of high versus low mean arterial pressure levels on clinical outcomes and complications in elderly patients during non-cardiothoracic surgery under general anesthesia: study protocol for a randomized controlled trial. | Anmin, Hu Yan, Qiu Peng, Zhang Bailong, Hu Yali, Yang Shutao, Li Rui, Zhao Zhongjun, Zhang Yaoxian, Zhang Zihao, Zheng Chen, Qiu Furong, Li Xiaolei, Gong Hu, Anmin Qiu, Yan Zhang, Peng Hu, Bailong Yang, Yali Li, Shutao Zhao, Rui | Trials | 2017 | |
| Association between baseline cognitive impairment and postoperative delirium in elderly patients undergoing surgery for adult spinal deformity. | Adogwa, O. Elsamadicy, A. A. Vuong, V. D. Fialkoff, J. Cheng, J. Karikari, I. O. Bagley, C. A. | J Neurosurg Spine | 2017 |
CAM = Confusion Assessment Method |
| Effect of the Hospital Elder Life Program on Risk of 30-Day Readmission. | Rubin, F. H. Bellon, J. Bilderback, A. Urda, K. Inouye, S. K. | Journal of the American Geriatrics Society | 2017 |
aged |
| Clinical outcomes in older surgical patients with mild cognitive impairment. | Racine, A. M. Fong, T. G. Gou, Y. Travison, T. G. Tommet, D. Erickson, K. Jones, R. N. Dickerson, B. C. Metzger, E. Marcantonio, E. R. Schmitt, E. M. Inouye, S. K. | Alzheimers Dement | 2017 |
Mild cognitive impairment |
| Prediction of Long-term Cognitive Decline Following Postoperative Delirium in Older Adults. | Devore EE, Fong TG, Marcantonio ER, Schmitt EM, Travison TG, Jones RN, Inouye SK | The journals of gerontology. Series A, Biological sciences and medical sciences | 2017 |
Aged |
| The Cognitive Reserve Model in the Development of Delirium: The Successful Aging After Elective Surgery Study. | Cizginer, S. Marcantonio, E. Vasunilashorn, S. Pascual-Leone, A. Shafi, M. Schmitt, E. M. Inouye, S. K. Jones, R. N. | J Geriatr Psychiatry Neurol | 2017 |
delirium |
| Incidence of Delirium Among Patients Having Cancer Injected With Different Opioids for the First Time. | Tanaka R, Ishikawa H, Sato T, Shino M, Matsumoto T, Mori K, Omae K, Osaka I | The American journal of hospice & palliative care | 2016 |
delirium |
| Complications after hip fracture surgery: are they preventable? | Flikweert, E. R. Wendt, K. W. Diercks, R. L. Izaks, G. J. Landsheer, D. Stevens, M. Reininga, I. H. F. | Eur J Trauma Emerg Surg | 2017 |
Complications |
| Pilot prospective study of post-surgery sleep and EEG predictors of post-operative delirium. | Evans, J. L. Nadler, J. W. Preud'homme, X. A. Fang, E. Daughtry, R. L. Chapman, J. B. Attarian, D. Wellman, S. Krystal, A. D. | Clin Neurophysiol | 2017 |
Aged |
| Development of an international undergraduate curriculum for delirium using a modified delphi process. | Copeland, C. Fisher, J. Teodorczuk, A. | Age Ageing | 2017 |
curriculum |
| Serum galectin-3 levels and delirium among postpartum intensive care unit women. | Zhu, Y. Hu, W. Zhu, M. L. Yin, T. Su, J. Wang, J. R. | Brain Behav | 2017 |
delirium |
| Characteristics of patients with an unplanned admission to an acute palliative care unit. | Mercadante, S. Adile, C. Ferrera, P. Casuccio, A. | Intern Emerg Med | 2017 |
Cancer |
| FRAIL Questionnaire Screening Tool and Short-Term Outcomes in Geriatric Fracture Patients. | Gleason, L. J. Benton, E. A. Alvarez-Nebreda, M. L. Weaver, M. J. Harris, M. B. Javedan, H. | J Am Med Dir Assoc | 2017 |
Frailty |
| Disruption of the ascending arousal system and cortical attention networks in post-stroke delirium and spatial neglect. | Boukrina, O. Barrett, A. M. | Neurosci Biobehav Rev | 2017 |
Aras |
| Incidence of delirium after cardiac surgery: protocol for the DELIRIUM-CS Canada cross-sectional cohort study. | DELIRIUM-CS Investigators, Canadian Cardiovascular Critical Care Society Investigator Group and the Canadian Critical Care Trials Group | CMAJ Open | 2017 | |
| Preoperative C-Reactive Protein as a Risk Factor for Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Surgery for Colon Carcinoma. | Xiang, Dong Xing, Hailin Tai, Huiyu Xie, Guozhu | BioMed Research International | 2017 | |
| Responding to Ten Common Delirium Misconceptions With Best Evidence: An Educational Review for Clinicians. | Oldham, M. A. Flanagan, N. M. Khan, A. Boukrina, O. Marcantonio, E. R. | J Neuropsychiatry Clin Neurosci | 2017 |
Cognitive Disorders |
| The network model of delirium. | Young JWS | Medical hypotheses | 2017 |
Default-mode network |
| Aging and Post-Intensive Care Syndrome: A Critical Need for Geriatric Psychiatry. | Wang, S. Allen, D. Kheir, Y. N. Campbell, N. Khan, B. | Am J Geriatr Psychiatry | 2017 |
Aging |
| Intensive care discharge delay is associated with increased hospital length of stay: A multicentre prospective observational study. | Tiruvoipati, R. Botha, J. Fletcher, J. Gangopadhyay, H. Majumdar, M. Vij, S. Paul, E. Pilcher, D. | PLoS One | 2017 |
Adolescent |
| How can we identify patients with delirium in the emergency department?: A review of available screening and diagnostic tools. | Tamune H, Yasugi D | The American journal of emergency medicine | 2017 |
Aged |
| Symptom profile as assessed on delirium rating scale-revised-98 of delirium in respiratory intensive care unit: A study from India. | Sharma, A. Malhotra, S. Grover, S. Jindal, S. K. | Lung India | 2017 | |
| Burst-suppression ratio underestimates absolute duration of electroencephalogram suppression compared with visual analysis of intraoperative electroencephalogram. | Muhlhofer, W. G. Zak, R. Kamal, T. Rizvi, B. Sands, L. P. Yuan, M. Zhang, X. Leung, J. M. | Br J Anaesth | 2017 | |
| Post-anaesthesia care unit delirium: incidence, risk factors and associated adverse outcomes. | Hernandez, B. A. Lindroth, H. Rowley, P. Boncyk, C. Raz, A. Gaskell, A. Garcia, P. S. Sleigh, J. Sanders, R. D. | Br J Anaesth | 2017 | |
| Validation of the 4AT questionnaire in the emergency department | Gagné, A. Voyer, P. Boucher, V. Pelletier, M. Gouin, E. Berthelot, S. Daoust, R. Laguë, A. Bédard, C. Émond, M. | Canadian Journal of Emergency Medicine | 2017 |
aged |
| Incidence, prognostic factors and impact of postoperative delirium after major vascular surgery: A meta-analysis and systematic review. | Aitken, S. J. Blyth, F. M. Naganathan, V. | Vasc Med | 2017 |
aging |
| Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium. | Yoshimura, A. Goodson, C. Johns, J. T. Towe, M. M. Irvine, E. S. Rendradjaja, N. A. Max, L. K. LaFlam, A. Ledford, E. C. Probert, J. Tieges, Z. Edwin, D. H. MacLullich, A. M. J. Hogue, C. W. Lindquist, M. A. Gurakar, A. Neufeld, K. J. Kamiya, A. | Sci Rep | 2017 | |
| Comprehensive geriatric care reduces acute perioperative delirium in elderly patients with hip fractures: A meta-analysis. | Wang, Y. Tang, J. Zhou, F. Yang, L. Wu, J. | Medicine | 2017 |
Aged |
| Effect of nocturnal sound reduction on the incidence of delirium in intensive care unit patients: An interrupted time series analysis. | van de Pol, I. van Iterson, M. Maaskant, J. | Intensive Crit Care Nurs | 2017 |
Aged |
| Poorer outcomes and greater healthcare costs for hospitalised older people with dementia and delirium: a retrospective cohort study. | Tropea J, LoGiudice D, Liew D, Gorelik A, Brand C | International journal of geriatric psychiatry | 2017 |
dementia |
| Attitudes, knowledge and practices concerning delirium: a survey among intensive care unit professionals. | Trogrlić, Zoran Ista, Erwin Ponssen, Huibert H. Schoonderbeek, Jeannette F. Schreiner, Frodo Verbrugge, Serge J. Dijkstra, Annemieke Bakker, Jan Jagt, Mathieu | Nursing in Critical Care | 2017 |
Attitude of Health Personnel |
| Can we predict a delirium after cardiac surgery? A validation study of a delirium risk checklist. | Ten Broeke, M. Koster, S. Konings, T. Hensens, A. G. van der Palen, J. | Eur J Cardiovasc Nurs | 2017 |
Delirium |
| Effects of closed-loop intravenous anesthesia guided by the Bispectral index in adult patients on emergence delirium. A randomized controlled study. | Cotoia, A. Mirabella, L. Beck, R. Matrella, P. Assenzo, V. Chazot, T. Cinnella, G. Liu, N. Dambrosio, M. | Minerva Anestesiol | 2017 | |
| Early impairment of intracranial conduction time predicts mortality in deeply sedated critically ill patients: a prospective observational pilot study. | Azabou, E. Rohaut, B. Heming, N. Magalhaes, E. Morizot-Koutlidis, R. Kandelman, S. Allary, J. Moneger, G. Polito, A. Maxime, V. Annane, D. Lofaso, F. Chretien, F. Mantz, J. Porcher, R. Sharshar, T. | Ann Intensive Care | 2017 |
Altered mental status |
| Prevalence of Delirium in a Population of Elderly Outpatients with Dementia: A Retrospective Study. | Addesi, D. Maio, R. Smirne, N. Laganà, V. Altomari, N. Puccio, G. Colao, R. Cupidi, C. Perticone, F. Bruni, A. C. | Journal of Alzheimer's Disease | 2017 |
antidepressant agent |
| Validation and Psychometric Properties of the German Version of the Delirium Motor Subtype Scale (DMSS). | Garcia Nunez, D. Boettger, S. Meyer, R. Richter, A. Schubert, M. Meagher, D. Jenewein, J. | Assessment | 2017 |
German version |
| Association of Helicobacter pylori with the Risk of Hepatic Encephalopathy. | Wijarnpreecha, K. Chesdachai, S. Thongprayoon, C. Jaruvongvanich, V. Ungprasert, P. Cheungpasitporn, W. | Dig Dis Sci | 2017 |
Helicobacter Infections/*complications |
| Determination of the feasibility of a multicomponent intervention program to prevent delirium in the Intensive Care Unit: A modified RAND Delphi study. | Wassenaar, A. van den Boogaard, M. Underpin-Icu Study, Group Schoonhoven, L. Pickkers, P. | Aust Crit Care | 2017 |
Delirium |
| Incidence, correlates and outcomes associated with falls in the intensive care unit: a retrospective cohort study. | Trumble, D. Meier, M. A. Doody, M. Wang, X. Bagshaw, S. M. | Crit Care Resusc | 2017 | |
| Impact of the Orthopaedic Nurse Practitioner role on acute hospital length of stay and cost-savings for patients with hip fracture: A retrospective cohort study. | Coventry, L. L. Pickles, S. Sin, M. Towell, A. Giles, M. Murray, K. Twigg, D. E. | J Adv Nurs | 2017 |
cost-savings |
| Prevalence and risk factors for delirium diagnosis in patients followed in general practices in Germany. | Bohlken, Jens Kostev, Karel | International Psychogeriatrics | 2017 |
delirium |
| Clinical benefits of single-incision laparoscopic surgery for postoperative delirium in elderly colon cancer patients. | Nishizawa, Y. Hata, T. Takemasa, I. Yamasaki, M. Akasaka, H. Sugimoto, K. Tamai, K. Takahashi, H. Haraguchi, N. Nishimura, J. Matsuda, C. Mizushima, T. Ikenaga, M. Yamamoto, H. Murata, K. Rakugi, H. Doki, Y. Mori, M. | Surg Endosc | 2017 |
aged |
| Evaluation of Cognitive Function Following Transcatheter Aortic Valve Replacement. | Abawi, M. de Vries, R. Stella, P. R. Agostoni, P. Boelens, D. H. M. van Jaarsveld, R. C. van Dongen, C. S. Doevendans, P. A. F. M. Emmelot-Vonk, M. H. | Heart Lung and Circulation | 2017 |
adult |
| Caring for a patient with delirium in an acute hospital: The lived experience of cardiology, elderly care, renal, and respiratory nurses. | Brooke, J. Manneh, C. | Int J Nurs Pract | 2018 |
aggression |
| Association between Delirium and Prehospitalization Medication in Poststroke Patients. | Hosoya, R. Sato, Y. Ishida, E. Shibamoto, H. Hino, S. Yokote, H. Kamata, T. | J Stroke Cerebrovasc Dis | 2018 |
Derilium |
| Acute Brain Dysfunction: Development and Validation of a Daily Prediction Model. | Marra, A. Pandharipande, P. P. Shotwell, M. S. Chandrasekhar, R. Girard, T. D. Shintani, A. K. Peelen, L. M. Moons, K. Dittus, R. S. Ely, E. W. Vasilevskis, E. E. | Chest | 2018 |
Coma |
| Delirium in the Elderly. | Hshieh, T. T. Inouye, S. K. Oh, E. S. | Psychiatr Clin North Am | 2018 |
Cognitive decline |
| Barriers to delirium assessment in the intensive care unit: A literature review. | Rowley-Conwy, G. | Intensive Crit Care Nurs | 2018 |
Critical Care Nursing/*methods |
| Exploratory and Confirmatory Factor Analyses of Delirium Symptoms in a Sample of Nursing Home Residents. | Moyo P, Huang TY, Simoni-Wastila L, Harrington D | Journal of applied gerontology : the official journal of the Southern Gerontological Society | 2016 |
confirmatory factor analysis |
| Neurosurgery in Octogenarians: A Prospective Study of Perioperative Morbidity, Mortality, and Complications in Elderly Patients. | Maldaner, N. Sarnthein, J. Bozinov, O. Regli, L. Neidert, M. C. | World Neurosurgery | 2018 |
glucocorticoid |
| Delirium in the Cardiac Intensive Care Unit. | Ibrahim, K. McCarthy, C. P. McCarthy, K. J. Brown, C. H. Needham, D. M. Januzzi, J. L., Jr. McEvoy, J. W. | J Am Heart Assoc | 2018 |
critical care |
| The Diagnostic Sensitivity of the Memorial Delirium Assessment Scale—Spanish Version | Barahona, E. Pinhao, R. Galindo, V. Noguera, A. | Journal of Pain and Symptom Management | 2018 |
adult |
| First- and second-line pharmacological treatment for delirium in general hospital setting-Retrospective analysis. | Wada, K. Morita, Y. Iwamoto, T. Mifune, Y. Nojima, S. | Asian J Psychiatr | 2018 |
Consultation liaison service |
| Increasing use of cognitive measures in the operational definition of frailty-A systematic review | Vella Azzopardi, R. Beyer, I. Vermeiren, S. Petrovic, M. Van Den Noortgate, N. Bautmans, I. Gorus, E. | Ageing Res Rev | 2018 |
Aged |
| Preoperative Hemoglobin Level is Associated with Increased Health Care Use After Elective Spinal Fusion (≥3 Levels) in Elderly Male Patients with Spine Deformity. | Elsamadicy, A. A. Adogwa, O. Ongele, M. Sergesketter, A. R. Tarnasky, A. Lubkin, D. E. T. Drysdale, N. Cheng, J. Bagley, C. A. Karikari, I. O. | World Neurosurg | 2018 |
aged |
| Comprehensive geriatric assessment for older people admitted to a surgical service. | Eamer, G. Taheri, A. Chen, S. S. Daviduck, Q. Chambers, T. Shi, X. Khadaroo, R. G. | Cochrane Database of Systematic Reviews | 2018 |
clinical assessment |
| Effects of a Medication Review on Delirium in Older Hospitalised Patients: A Comparative Retrospective Cohort Study. | van Velthuijsen, E. L. Zwakhalen, S. M. G. Pijpers, E. van de Ven, L. I. Ambergen, T. Mulder, W. J. Verhey, F. R. J. Kempen, Gijm | Drugs Aging | 2018 | |
| Effect of haloperidol on survival among critically ill adults with a high risk of delirium the REDUCE randomized clinical trial | Van Den Boogaard, M. Slooter, A. J. C. Brüggemann, R. J. M. Schoonhoven, L. Beishuizen, A. Vermeijden, J. W. Pretorius, D. De Koning, J. Simons, K. S. Dennesen, P. J. W. Van Der Voort, P. H. J. Houterman, S. Van Der Hoeven, J. G. Pickkers, P. | JAMA | 2018 |
adult |
| Individualized Acute Medical Care for Cognitively Impaired Individuals: A Call Always to Pause Before Hospitalization. | Sheckter, C. C. Bott, N. T. Milstein, A. Leff, B. | J Am Geriatr Soc | 2018 |
cognitive defect |
| Baden Prevention and Reduction of Incidence of Postoperative Delirium Trial (PRIDe): a phase IV multicenter, randomized, placebo-controlled, double-blind clinical trial of ketamine versus haloperidol for prevention of postoperative delirium. | Riegger, H. Hollinger, A. Seifert, B. Toft, K. Blum, A. Zehnder, T. Siegemund, M. | Trials | 2018 |
Dos |
| Frequency and predictors of post-stroke delirium in PRospective Observational POLIsh Study (PROPOLIS) | Pasinska, P. Kowalska, K. Klimiec, E. Szyper-Maciejowska, A. Wilk, A. Klimkowicz-Mrowiec, A. | J Neurol | 2018 |
Delirium |
| Hypertension, mitral valve disease, atrial fibrillation and low education level predict delirium and worst outcome after cardiac surgery in older adults. | Oliveira, F. R. Oliveira, V. H. Oliveira, I. M. Lima, J. W. Calderaro, D. Gualandro, D. M. Caramelli, B. | BMC Anesthesiology | 2018 |
*Cardiac surgery |
| Delirium, Frailty, and Fast-Track Surgery in Oncogeriatrics: Is There a Link? | Monacelli, F. Signori, A. Prefumo, M. Giannotti, C. Nencioni, A. Romairone, E. Scabini, S. Odetti, P. | Dementia and Geriatric Cognitive Disorders Extra | 2018 |
aged |
| Confusion Strongly Associated with Antibiotic Prescribing Due to Suspected Urinary Tract Infections in Nursing Homes. | Mayne, S. Sundvall, P. D. Gunnarsson, R. | J Am Geriatr Soc | 2018 |
urinary catheter |
| Suvorexant is associated with a low incidence of delirium in critically ill patients: a retrospective cohort study. | Masuyama, T. Sanui, M. Yoshida, N. Iizuka, Y. Ogi, K. Yagihashi, S. Nagatomo, K. Sasabuchi, Y. Lefor, A. K. | Psychogeriatrics | 2018 |
critically ill |
| Do Risk Prediction Models for Postoperative Delirium Consider Patients' Preoperative Medication Use? | Kassie, G. M. Nguyen, T. A. Kalisch Ellett, L. M. Pratt, N. L. Roughead, E. E. | Drugs Aging | 2018 | |
| Predictors and Outcomes of Cardiac Surgery-Associated Delirium. A Single Centre Retrospective Cohort Study. | Jones, D. Matalanis, G. Martensson, J. Robbins, R. Shaw, M. Seevanayagam, S. Cowie, D. Bellomo, R. | Heart Lung Circ | 2018 |
Cardiac surgery |
| Delirium in older hospitalized patients-signs and actions: a retrospective patient record review. | Johansson, Y. A. Bergh, I. Ericsson, I. Sarenmalm, E. K. | BMC Geriatr | 2018 |
*Action by healthcare professionals |
| Delirium-A Framework to Improve Acute Care for Older Persons. | Inouye, S. K. | J Am Geriatr Soc | 2018 |
Acute care for elders |
| The minimal clinically important difference of the Richmond Agitation-Sedation Scale in patients with cancer with agitated delirium. | Hui, D. Hess, K. Dibaj, S. S. Arthur, J. Dev, R. Dalal, S. Reddy, S. Bruera, E. | Cancer | 2018 |
delirium |
| The use of cerebral imaging for investigating delirium aetiology. | Hijazi, Z. Lange, P. Watson, R. Maier, A. B. | Eur J Intern Med | 2018 |
Delirium |
| Medication Profiles of Patients with Cognitive Impairment and High Anticholinergic Burden. | Green, A. R. Reifler, L. M. Boyd, C. M. Weffald, L. A. Bayliss, E. A. | Drugs Aging | 2018 | |
| Delirium Assessment Tools for Use in Critically Ill Adults: A Psychometric Analysis and Systematic Review. | Gelinas, C. Berube, M. Chevrier, A. Pun, B. T. Ely, E. W. Skrobik, Y. Barr, J. | Crit Care Nurse | 2018 | |
| Postoperative Delirium in Glioblastoma Patients: Risk Factors and Prognostic Implications. | Flanigan, P. M. Jahangiri, A. Weinstein, D. Dayani, F. Chandra, A. Kanungo, I. Choi, S. Sankaran, S. Molinaro, A. M. McDermott, M. W. Berger, M. S. Aghi, M. K. | Neurosurgery | 2018 | |
| The delirium and population health informatics cohort study protocol: ascertaining the determinants and outcomes from delirium in a whole population. | Davis, D. Richardson, S. Hornby, J. Bowden, H. Hoffmann, K. Weston-Clarke, M. Green, F. Chaturvedi, N. Hughes, A. Kuh, D. Sampson, E. Mizoguchi, R. Cheah, K. L. Romain, M. Sinha, A. Jenkin, R. Brayne, C. MacLullich, A. | BMC Geriatr | 2018 |
*Delirium |
| Cerebral oximetry during preoperative resuscitation in elderly patients with hip fracture: a prospective observational study. | Clemmesen, C. G. Pedersen, L. M. Hougaard, S. Andersson, M. L. Rosenkvist, V. Nielsen, H. B. Palm, H. Foss, N. B. | J Clin Monit Comput | 2018 |
Delirium |
| Clinical characteristics associated with the onset of delirium among long-term nursing home residents. | Cheung, E. N. M. Benjamin, S. Heckman, G. Ho, J. M. Lee, L. Sinha, S. K. Costa, A. P. | BMC Geriatr | 2018 |
*Delirium |
| Evaluation of a multicomponent pathway to address inpatient delirium on a neurosciences ward. | Brown, E. G. Josephson, S. A. Anderson, N. Reid, M. Lee, M. Douglas, V. C. | BMC Health Serv Res | 2018 |
*Cognitive aging |
| Subsyndromal delirium in the intensive care setting: Phenomenological characteristics and discrimination of subsyndromal delirium versus no and full-syndromal delirium. | Boettger S, Nuñez DG, Meyer R, Richter A, Schubert M, Jenewein J | Palliative & supportive care | 2017 |
Diagnostic and Statistical Manual of Mental Disorders |
| Incidence, risk factors, and clinical implications of post-operative delirium in lung transplant recipients. | Anderson, B. J. Chesley, C. F. Theodore, M. Christie, C. Tino, R. Wysoczanski, A. Ramphal, K. Oyster, M. Kalman, L. Porteous, M. K. Bermudez, C. A. Cantu, E. Kolson, D. L. Christie, J. D. Diamond, J. M. | J Heart Lung Transplant | 2018 |
acidic protein |
| Delirium and correlates of delirium among newly admitted elderly patients: A crosssectional study in a Saudi general hospital. | Alamri, S. H. Ashanqity, O. A. Alshomrani, A. B. Elmasri, A. H. Saeed, M. B. Yahya, S. A. Almasoud, A. I. Adam, Y. Alamoudi, H. M. Mukhtar, A. M. | Annals of Saudi Medicine | 2018 |
urinary catheter |
| Preoperative Cognitive Impairment As a Predictor of Postoperative Outcomes in a Collaborative Care Model. | Zietlow, K. McDonald, S. R. Sloane, R. Browndyke, J. Lagoo-Deenadayalan, S. Heflin, M. T. | J Am Geriatr Soc | 2018 |
co-management |