What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Elevated TDP-43 serum levels associated with postoperative delirium following major cardiac surgery
- Authors
- Simon, C. Graves, O. K. Akeju, O. McKay, T. B.
- Year
- 2025
- Journal
- Brain Behav Immun Health
- Abstract
BACKGROUND: Postoperative delirium is a recurring complication among vulnerable patients undergoing major cardiac surgery. While delirium has been associated with prodromal dementia, there is minimal evidence to support the causality of this nuanced relationship. Clarification as to how postoperative delirium might lead to neurodegenerative dementias, perhaps through evidence of contemporaneous biomarkers, would heighten the plausibility of a causal correlation. TAR DNA-binding protein 43 (TDP-43), a nuclear protein essential for transcriptional events, has been linked to pathological aggregation in Alzheimer’s disease (AD) and AD-related dementias (ADRD). METHODS: Circulating TDP-43 levels in cardiac surgical patients aged 60 years and older were evaluated in a biobank derived from the Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS) clinical trial. Serum total TDP-43 levels, measured with a single molecule array (Simoa), were compared across preoperative and postoperative day one timepoints according to delirium status assessed using the Confusion Assessment Method (CAM). To investigate the temporal changes in serum TDP-43, an independent validation cohort of 25 patients aged 60 years and older undergoing major cardiac surgery was analyzed. RESULTS: Total serum TDP-43 levels increased by 16.5% (95% CI: 5.9%-27.9%, p = 0.0021) on postoperative day one compared to baseline levels. This increase was more pronounced in patients who experienced delirium (median increase of 55.1%, 95% CI: 22.9%-96.4%, p = 0.0002). Further, these findings were conserved in multiple logistic regression models adjusting for treatment, age, sex, and baseline cognitive scores. In the validation cohort, TDP-43 levels were found to be significantly elevated immediately following cardiopulmonary bypass from the baseline, with a gradual decrease by postoperative day one. CONCLUSIONS: Our findings demonstrate that post-cardiac surgery delirium among vulnerable patients is associated with significant elevations in circulating TDP-43. This relationship suggests that TDP-43 may serve as a prognostic biomarker for acute neurological insults and blood-brain barrier integrity following cardiac surgery. Overall, our results provide mechanistic insights into the inter-relationship between postoperative delirium and subsequent cognitive impairment, potentially offering new avenues for early intervention in at-risk surgical patients.
- PMID
PMID: 40134937
PMCID: PMC11932660
- Keywords
Postoperative delirium, vulnerable patients, major cardiac surgery, prodromal dementia, TDP-43
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Managing delirium behaviors with one-to-one sitters. | Colella, J. Aroh, D. Douglas, C. VanBuitenen, N. Galesi, J. Castro, A. Tank, L. Parulekar, M. Menacker, M. | Nurs Manage | 2017 | |
| Clinical Assessment and Management of Delirium in the Palliative Care Setting | Bush, Shirley Lawlor, Peter Tierney, Sallyanne | Drugs | 2017 |
Delirium — Therapy |
| Perceptions of workload burden and adherence to ABCDE bundle among intensive care providers. | Boehm, Leanne M. | American Journal of Critical Care | 2017 |
Critical Care Nursing |
| Optimizing Surgical Quality Datasets to Care for Older Adults: Lessons from the American College of Surgeons NSQIP Geriatric Surgery Pilot. | Berian, J. R. Zhou, L. Hornor, M. A. Russell, M. M. Cohen, M. E. Finlayson, E. Ko, C. Y. Robinson, T. N. Rosenthal, R. A. | J Am Coll Surg | 2017 | |
| Post-ICU psychological morbidity in very long ICU stay patients with ARDS and delirium. | Bashar, F. R. Vahedian-Azimi, A. Hajiesmaeili, M. Salesi, M. Farzanegan, B. Shojaei, S. Goharani, R. Madani, S. J. Moghaddam, K. G. Hatamian, S. Moghaddam, H. J. Mosavinasab, S. M. M. Elamin, E. M. Miller, A. C. | J Crit Care | 2017 |
Acute respiratory distress syndrome |
| The prevalence of undiagnosed pre-surgical cognitive impairment and its post-surgical clinical impact in elderly patients undergoing surgery for adult spinal deformity. | Adogwa, O. Elsamadicy, A. A. Lydon, E. Vuong, V. D. Cheng, J. Karikari, I. O. Bagley, C. A. | J Spine Surg | 2017 |
Surgery |
| A comparison of outcomes according to different diagnostic systems for delirium (DSM-5, DSM-IV, CAM, and DRS-R98). | Adamis, D. Meagher, D. Rooney, S. Mulligan, O. McCarthy, G. | Int Psychogeriatr | 2017 |
Dsm |
| Antipsychotic prescription to identify delirium: results from two cohorts. | Zimmerman, K. M. Paquin, A. M. Rudolph, J. L. | Clin Pharmacol | 2017 |
delirium antipsychotic aged |
| Preoperative severe hypoalbuminemia is associated with an increased risk of postoperative delirium in elderly patients: Results of a secondary analysis. | Zhang, D. F. Su, X. Meng, Z. T. Cui, F. Li, H. L. Wang, D. X. Li, X. Y. | J Crit Care | 2017 |
Delirium |
| Rivastigmine patch reduces the incidence of postoperative delirium in older patients with cognitive impairment | Young, Y. C. Shin, H. W. Choi, B. S. Kim, S. Lee, J. Y. Ha, Y. C. | Int J Geriatr Psychiatry | 2017 |
acetylcholinesterase inhibitors |
| Effects of nimodipine on postoperative delirium in elderly under general anesthesia: A prospective, randomized, controlled clinical trial | Ya-Nan, Li Qi, Zhang Chun-Ping, Yin Yang-Yang, Guo Shu-Ping, Huo Liang, Wang Qiu-Jun, Wang Li, Ya-Nan Zhang, Qi Yin, Chun-Ping Guo, Yang-Yang Huo, Shu-Ping Wang, Liang Wang, Qiu-Jun | Medicine | 2017 | |
| Association of intraoperative changes in brain-derived neurotrophic factor and postoperative delirium in older adults. | Wyrobek, J. LaFlam, A. Max, L. Tian, J. Neufeld, K. J. Kebaish, K. M. Walston, J. D. Hogue, C. W. Riley, L. H. Everett, A. D. Brown, C. H. th | Br J Anaesth | 2017 |
Bdnf |
| Preoperative geriatric assessment reduced hospital stay and complications in patients ≥65 y having vascular surgery. | Weed, H. G. | Annals of Internal Medicine | 2017 |
ISRCTN23142588 |
| The Risk Factors of Postoperative Delirium after Total Knee Arthroplasty. | Wang, L. Seok, S. Kim, S. Kim, K. Lee, S. Lee, K. | J Knee Surg | 2017 | |
| Risk factors for the incidence of delirium in cerebrovascular patients in a Neurosurgery Intensive Care Unit: A prospective study. | Wang, J. Ji, Y. Wang, N. Chen, W. Bao, Y. Qin, Q. Xiao, Q. Li, S. | J Clin Nurs | 2017 |
delirium (mental health nursing) |
| Clock-Drawing Test as a Bedside Assessment of Post-operative Delirium Risk in Elderly Patients with Accidental Hip Fracture. | Vasilian, C. C. Tamasan, S. C. Lungeanu, D. Poenaru, D. V. | World J Surg | 2017 | |
| A prospective observational study to investigate utility of the Delirium Observational Screening Scale (DOSS) to detect delirium in care home residents. | Teale, E. A. Munyombwe, T. Schuurmans, M. Siddiqi, N. Young, J. | Age & Ageing | 2017 |
Delirium Observation Screening Scale |
| Randomized phase II study of TJ-54 (Yokukansan) for postoperative delirium in gastrointestinal and lung malignancy patients. | Sugano, N. Aoyama, T. Sato, T. Kamiya, M. Amano, S. Yamamoto, N. Nagashima, T. Ishikawa, Y. Masudo, K. Taguri, M. Yamanaka, T. Yamamoto, Y. Matsukawa, H. Shiraisi, R. Oshima, T. Yukawa, N. Rino, Y. Masuda, M. | Mol Clin Oncol | 2017 |
Yokukansan |
| Postoperative delirium in elderly patients is associated with subsequent cognitive impairment. | Sprung, J. Roberts, R. O. Weingarten, T. N. Nunes Cavalcante, A. Knopman, D. S. Petersen, R. C. Hanson, A. C. Schroeder, D. R. Warner, D. O. | Br J Anaesth | 2017 |
aged, humans |
| Delirium Following Transcatheter Aortic Valve Replacement: National Inpatient Sample Analysis. | Soundhar, A. Udesh, R. Mehta, A. Schindler, J. Jeevanantham, V. Gleason, T. Thirumala, P. D. | Journal of Cardiothoracic and Vascular Anesthesia | 2017 |
carotid artery obstruction |
| The Effects of Delirium Prevention Guidelines on Elderly Stroke Patients | Song, J. Lee, M. Jung, D. | Clin Nurs Res | 2017 |
delirium |
| Postoperative Delirium in Elderly Patients Undergoing Major Spinal Surgery: Role of Cerebral Oximetry. | Soh S, Shim JK, Song JW, Kim KN, Noh HY, Kwak YL | Journal of neurosurgical anesthesiology | 2016 | |
| Age and gender-related peculiarities of patients with delirium in the cardiac intensive care unit. | Serpytis, P. Navickas, P. Navickas, A. Serpytis, R. Navickas, G. Glaveckaite, S. | Kardiol Pol | 2017 |
Iccu |
| Outcomes of subsyndromal delirium in ICU: a systematic review and meta-analysis. | Serafim, R. B. Soares, M. Bozza, F. A. Lapa, E. Silva J. R. Dal-Pizzol, F. Paulino, M. C. Povoa, P. Salluh, J. I. F. | Crit Care | 2017 |
Critically ill |
| Haloperidol versus placebo for delirium prevention in acutely hospitalised older at risk patients: a multi-centre double-blind randomised controlled clinical trial. | Schrijver, E. J. M. de Vries, O. J. van de Ven, P. M. Bet, P. M. Kamper, A. M. Diepeveen, S. H. A. van Marum, R. J. van Strien, A. M. Anten, S. Lagaay, A. M. Boelaarts, L. Bloemers, F. W. Kramer, M. H. H. Nanayakkara, P. W. B. | Age & Ageing | 2017 |
aged 80 and over |
| The impact of delirium on outcomes in acute, non-intubated cardiac patients. | Sato K, Kubota K, Oda H, Taniguchi T | European heart journal. Acute cardiovascular care | 2015 |
Aging |
| Epidemiology and outcomes of people with dementia, delirium, and unspecified cognitive impairment in the general hospital: prospective cohort study of 10,014 admissions. | Reynish, Emma L. Hapca, Simona M. De Souza, Nicosha Cvoro, Vera Donnan, Peter T. Guthrie, Bruce | BMC Medicine | 2017 | |
| Alzheimer's-related cortical atrophy is associated with postoperative delirium severity in persons without dementia. | Racine, A. M. Fong, T. G. Travison, T. G. Jones, R. N. Gou, Y. Vasunilashorn, S. M. Marcantonio, E. R. Alsop, D. C. Inouye, S. K. Dickerson, B. C. | Neurobiol Aging | 2017 |
Alzheimer’s disease |
| Delayed Recall and Working Memory MMSE Domains Predict Delirium following Cardiac Surgery. | Price, C. C. Garvan, C. Hizel, L. Lopez, M. G. Billings, F. T. | J Alzheimers Dis | 2017 |
Alzheimer’s disease |
| The detection, diagnosis, and impact of cognitive impairment among inpatients aged 65 years and over in an Irish general hospital - a prospective observational study. | Power, C. Duffy, R. Bates, H. Healy, M. Gleeson, P. Lawlor, B. A. Greene, E. | Int Psychogeriatr | 2017 |
cognitive impairment |
| Incidence and predictors of postoperative delirium after cytoreduction surgery-hyperthermic intraperitoneal chemotherapy. | Plas, M. Hemmer, P. H. J. Been, L. B. van Ginkel, R. J. de Bock, G. H. van Leeuwen, B. L. | J Surg Oncol | 2017 |
C-reactive protein |
| Role of Ramelteon in Reduction of As-Needed Antipsychotics in Elderly Patients with Delirium in a General Hospital Setting. | Pinkhasov, A. James, S. A. Fazzari, M. Singh, D. Lam, S. | Clin Drug Investig | 2017 | |
| Delirium after fast-track hip and knee arthroplasty - a cohort study of 6331 elderly patients. | Petersen, P. B. Jorgensen, C. C. Kehlet, H. | Acta Anaesthesiol Scand | 2017 | |
| Delirium Risk of Dexmedetomidine and Midazolam in Patients Treated with Postoperative Mechanical Ventilation: a Meta-analysis. | Peng, W. Shimin, S. Hongli, W. Yanli, Z. Ying, Z. | Open Med | 2017 |
Delirium |
| Humanizing the treatment of hyperactive delirium in the last days of life. | Pandharipande, P. P. Ely, E. W. | JAMA | 2017 |
haloperidol |
| Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation (MoDUS): a randomised, double-blind, placebo-controlled trial. | Page, V. J. Casarin, A. Ely, E. W. Zhao, X. B. McDowell, C. Murphy, L. McAuley, D. F. | Lancet Respir Med | 2017 | |
| The effect of nonpharmacological training on delirium identification and intervention strategies of intensive care nurses. | Ozturk Birge, A. Tel Aydin, H. | Intensive Crit Care Nurs | 2017 |
Adult |
| Validation of the 6-Item Cognitive Impairment Test and the 4AT test for combined delirium and dementia screening in older Emergency Department attendees. | O'Sullivan, D. Brady, N. Manning, E. O'Shea, E. O'Grady, S. O. ' Regan N Timmons, S. | Age & Ageing | 2017 |
delirium |
| Risk factors for delirium after cardiac surgery: a historical cohort study outlining the influence of cardiopulmonary bypass. | O'Neal, J. B. Billings, F. T. th Liu, X. Shotwell, M. S. Liang, Y. Shah, A. S. Ehrenfeld, J. M. Wanderer, J. P. Shaw, A. D. | Can J Anaesth | 2017 | |
| A systematic review and meta-analysis of factors for delirium in vascular surgical patients. | Oldroyd, C. Scholz, A. F. M. Hinchliffe, R. J. McCarthy, K. Hewitt, J. Quinn, T. J. | J Vasc Surg | 2017 |
Delirium/diagnosis/*etiology/psychology/therapy |
| Detection and Management of Preexisting Cognitive Impairment in the Critical Care Unit. | Oldham, M. A. Piddoubny, W. Peterson, R. Lee, H. B. | Crit Care Clin | 2017 |
Behavioral and psychological symptoms in dementia |
| Delirium in older persons: Advances in diagnosis and treatment. | Oh, E. S. Fong, T. G. Hshieh, T. T. Inouye, S. K. | JAMA | 2017 |
biological marker |
| Prevalence for delirium in stroke patients: A prospective controlled study. | Nydahl, P. Bartoszek, G. Binder, A. Paschen, L. Margraf, N. G. Witt, K. Ewers, A. | Brain Behav | 2017 |
Confusion Assessment Method |
| Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study. | Neerland, B. E. Krogseth, M. Juliebo, V. Hylen Ranhoff, A. Engedal, K. Frihagen, F. Raeder, J. Bruun Wyller, T. Watne, L. O. | PloS One | 2017 | |
| Identification of patients with cancer with a high risk to develop delirium. | Neefjes, E. C. W. van der Vorst, Mjdl Verdegaal, Batt Beekman, A. T. F. Berkhof, J. Verheul, H. M. W. | Cancer Med | 2017 |
Cancer |
| Perioperative prediction of agitated (hyperactive) delirium after cardiac surgery in adults - The development of a practical scorecard. | Mufti, H. N. Hirsch, G. M. | J Crit Care | 2017 |
Cabg |
| Development and validation of an automated delirium risk assessment system (Auto-DelRAS) implemented in the electronic health record system. | Moon, K. J. Jin, Y. Jin, T. Lee, S. M. | Int J Nurs Stud | 2017 |
Auto-DelRAS |
| Efficacy of Ramelteon for delirium after lung cancer surgery. | Miyata R, Omasa M, Fujimoto R, Ishikawa H, Aoki M | Interactive cardiovascular and thoracic surgery | 2016 |
indene derivative |
| Risk Factors for Postoperative Delirium in Abdominal Surgery: A Proposal of a Postoperative Delirium Risk Score in Abdominal Surgery. | Miyagawa, Y. Yokoyama, Y. Fukuzawa, S. Fukata, S. Ando, M. Kawamura, T. Yamada, K. Nagino, M. | Digestive Surgery | 2017 |
serum albumin |
| Long-term cognitive impairment and delirium in intensive care: A prospective cohort study. | Mitchell, M. L. Shum, D. H. K. Mihala, G. Murfield, J. E. Aitken, L. M. | Aust Crit Care | 2017 |
Cognition |
| Prevalence of delirium in advanced cancer patients in home care and hospice and outcomes after 1 week of palliative care. | Mercadante, S. Masedu, F. Balzani, I. De Giovanni, D. Montanari, L. Pittureri, C. Berte, R. Russo, D. Ursini, L. Marinangeli, F. Aielli, F. | Support Care Cancer | 2017 |
Advanced cancer |
| Characterizing and predicting rates of delirium across general hospital settings. | McCoy, Thomas H. Hart, Kamber L. Perlis, Roy H. | General Hospital Psychiatry | 2017 |
Delirium |
| Environmental and Clinical Risk Factors for Delirium in a Neurosurgical Center: A Prospective Study. | Matano, F. Mizunari, T. Yamada, K. Kobayashi, S. Murai, Y. Morita, A. | World Neurosurg | 2017 |
Delirium |
| Genetic and environmental factors associated with delirium severity in older adults with dementia | Massimo, Lauren Munoz, Elizabeth Hill, Nikki Mogle, Jacqueline Mulhall, Paula McMillan, Corey T. Clare, Linda Vandenbergh, David Fick, Donna Kolanowski, Ann | International Journal of Geriatric Psychiatry | 2017 |
delirium |
| Delirium in Hospitalized Older Adults. | Marcantonio, E. R. | N Engl J Med | 2017 |
Aged |
| A post cardiac surgery intervention to manage delirium involving families: a randomized pilot study. | Mailhot, T. Cossette, S. Cote, J. Bourbonnais, A. Cote, M. C. Lamarche, Y. Denault, A. | Nurs Crit Care | 2017 |
Cardiac surgery |
| The influence of analgesic-based sedation protocols on delirium and outcomes in critically ill patients: A randomized controlled trial. | Liu, D. Lyu, J. Zhao, H. An, Y. | PloS One | 2017 |
Adolescent |
| Impact of dexmedetomidine on the incidence of delirium in elderly patients after cardiac surgery: A randomized controlled trial. | Li, X. Yang, J. Nie, X. L. Zhang, Y. Li, X. Y. Li, L. H. Wang, D. X. Ma, D. | PloS One | 2017 |
NCT02267538 |
| Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial. | Leung, J. M. Sands, L. P. Chen, N. Ames, C. Berven, S. Bozic, K. Burch, S. Chou, D. Covinsky, K. Deviren, V. Kinjo, S. Kramer, J. H. Ries, M. Tay, B. Vail, T. Weinstein, P. Chang, S. Meckler, G. Newman, S. Tsai, T. Voss, V. Youngblom, E. | Anesthesiology | 2017 | |
| Cerebral oximetry and postoperative delirium after cardiac surgery: a randomised, controlled trial. | Lei, L. Katznelson, R. Fedorko, L. Carroll, J. Poonawala, H. Machina, M. Styra, R. Rao, V. Djaiani, G. | Anaesthesia | 2017 |
cardiac surgery |
| Psychiatric symptomatology after delirium: a systematic review. | Langan, C. Sarode, D. P. Russ, T. C. Shenkin, S. D. Carson, A. Maclullich, A. M. J. | Psychogeriatrics | 2017 |
anxiety |
| Multicenter assessment of sedation and delirium practices in the intensive care units in Poland - is this common practice in Eastern Europe? | Kotfis, K. Zegan-Barańska, M. Zukowski, M. Kusza, K. Kaczmarczyk, M. Ely, E. W. | BMC Anesthesiology | 2017 |
benzodiazepine derivative |
| Complications Associated With Spine Surgery in Patients Aged 80 Years or Older: Japan Association of Spine Surgeons with Ambition (JASA) Multicenter Study | Kobayashi, K. Imagama, S. Ando, K. Ishiguro, N. Yamashita, M. Eguchi, Y. Matsumoto, M. Ishii, K. Hikata, T. Seki, S. Terai, H. Suzuki, A. Tamai, K. Aramomi, M. Ishikawa, T. Kimura, A. Inoue, H. Inoue, G. Miyagi, M. Saito, W. Yamada, K. Hongo, M. Nishimura | Global Spine J | 2017 |
anticoagulant agent |
| Risk Factors for Delirium After Spine Surgery in Extremely Elderly Patients Aged 80 Years or Older and Review of the Literature: Japan Association of Spine Surgeons with Ambition Multicenter Study. | Kobayashi, K. Imagama, S. Ando, K. Ishiguro, N. Yamashita, M. Eguchi, Y. Matsumoto, M. Ishii, K. Hikata, T. Seki, S. Terai, H. Suzuki, A. Tamai, K. Aramomi, M. Ishikawa, T. Kimura, A. Inoue, H. Inoue, G. Miyagi, M. Saito, W. Yamada, K. Hongo, M. Matsuoka, | Global Spine J | 2017 |
complication |
| Delirium characteristics and outcomes in medical and surgical lnpatients: A subgroup analysis. | Kim, S. Kim, J. J. Oh, J. Park, J. Park, J. Y. | J Crit Care | 2017 |
Delirium duration |
| Persistence of Delirium after Cessation of Sedatives and Analgesics and Impact on Clinical Outcomes in Critically Ill Patients. | Kenes, M. T. Stollings, J. L. Wang, L. Girard, T. D. Ely, E. W. Pandharipande, P. P. | Pharmacotherapy | 2017 |
critical care |
| South Korean Family Caregiver Involvement in Delirium Care: A Qualitative Descriptive Study. | Kang, Y. Moyle, W. Cooke, M. O'Dwyer, S. | J Gerontol Nurs | 2017 | |
| Validity of the Delirium Observation Screening Scale in Identifying Delirium in Home Hospice Patients. | Jorgensen SM, Carnahan RM, Weckmann MT | The American journal of hospice & palliative care | 2016 |
delirium screening |
| Discharge Plans for Geriatric Inpatients with Delirium: A Plan to Stop Antipsychotics? | Johnson, K. G. Fashoyin, A. Madden-Fuentes, R. Muzyk, A. J. Gagliardi, J. P. Yanamadala, M. | J Am Geriatr Soc | 2017 |
Aged |
| Preoperative Risk Factors for Subsyndromal Delirium in Older Adults Who Undergo Joint Replacement Surgery. | Denny, D. L. Lindseth, G. | Orthop Nurs | 2017 | |
| Validating the 4A's test in screening for delirium in a culturally diverse geriatric inpatient population. | De, J. Wand, A. P. F. Smerdely, P. I. Hunt, G. E. | Int J Geriatr Psychiatry | 2017 |
delirium screening |
| Delirium, frailty and mortality: interactions in a prospective study of hospitalized older people. | Dani, M. Owen, L. H. Jackson, T. A. Rockwood, K. Sampson, E. L. Davis, D. | J Gerontol A Biol Sci Med Sci | 2017 |
Outcomes |
| Impact of inhalational versus intravenous anaesthesia on early delirium and long-term survival in elderly patients after cancer surgery: study protocol of a multicentre, open-label, and randomised controlled trial. | Zhang, Y. Li, H. J. Wang, D. X. Jia, H. Q. Sun, X. D. Pan, L. H. Ye, Q. S. Ouyang, W. Jia, Z. Zhang, F. X. Guo, Y. Q. Ai, Y. Q. Zhao, B. J. Yang, X. D. Zhang, Q. G. Yin, N. Tan, H. Y. Liu, Z. H. Yu, J. B. Ma, D. | BMJ Open | 2017 |
anaesthesia in oncology |
| Hypertonic saline for prevention of delirium in geriatric patients who underwent hip surgery. | Xin, X. Xin, F. Chen, X. Zhang, Q. Li, Y. Huo, S. Chang, C. Wang, Q. | J Neuroinflammation | 2017 |
Cytokines |
| Delirium and Catatonia in Critically Ill Patients: The Delirium and Catatonia Prospective Cohort Investigation. | Wilson, J. E. Carlson, R. Duggan, M. C. Pandharipande, P. Girard, T. D. Wang, L. Thompson, J. L. Chandrasekhar, R. Francis, A. Nicolson, S. E. Dittus, R. S. Heckers, S. Ely, E. W. | Crit Care Med | 2017 |
Aged |
| Ketamine for the acute management of excited delirium and agitation in the prehospital setting. | Weant, K. A. Linder, L. M. Ross, C. A. | Pharmacotherapy | 2017 |
Agitation |
| Improved detection of delirium, implementation and validation of the CAM-ICU in elderly Emergency Department patients. | Van de Meeberg EK, Festen S, Kwant M, Georg RR, Izaks GJ, Ter Maaten JC | European journal of emergency medicine : official journal of the European Society for Emergency Medicine | 2016 | |
| Delirium symptoms are associated with decline in cognitive function between ages 53 and 69 years: Findings from a British birth cohort study. | Tsui, A. Kuh, D. Richards, M. Davis, D. | Alzheimers Dement | 2017 |
Cognitive decline |
| Delirium is associated with increased mortality in the geriatric population. | Tosun Tasar, P. Sahin, S. Akcam, N. O. Dinckal, C. Ulusoy, M. G. Sarikaya, O. F. Duman, S. Akcicek, F. Noyan, A. | Int J Psychiatry Clin Pract | 2017 |
Delirium |
| Disturbances in Oxygen Balance During Cardiopulmonary Bypass: A Risk Factor for Postoperative Delirium. | Smulter, N. Lingehall, H. C. Gustafson, Y. Olofsson, B. Engström, K. G. Appelblad, M. Svenmarker, S. | J Cardiothorac Vasc Anesth | 2017 |
aged |
| Perceptions of Family Members, Nurses, and Physicians on Involving Patients' Families in Delirium Prevention. | Smithburger, P. L. Korenoski, A. S. Kane-Gill, S. L. Alexander, S. A. | Crit Care Nurse | 2017 | |
| Perceptions of Families of Intensive Care Unit Patients Regarding Involvement in Delirium-Prevention Activities: A Qualitative Study. | Smithburger, P. L. Korenoski, A. S. Alexander, S. A. Kane-Gill, S. L. | Crit Care Nurse | 2017 | |
| A Predictive Model of the Prevalence of Delirium in Elderly Subjects Admitted to Nursing Homes. | Perez-Ros, P. Martinez-Arnau, F. M. Baixauli-Alacreu, S. Garcia-Gollarte, J. F. Tarazona-Santabalbina, F. | Endocr Metab Immune Disord Drug Targets | 2017 |
Delirium |
| Incidence and Risk Factors for Postoperative Delirium in Patients After Hepatectomy. | Park SA, Tomimaru Y, Shibata A, Miyagawa S, Noguchi K, Dono K | World journal of surgery | 2017 | |
| Five short screening tests in the detection of prevalent delirium: diagnostic accuracy and performance in different neurocognitive subgroups. | O'Regan, N. A. Maughan, K. Liddy, N. Fitzgerald, J. Adamis, D. Molloy, D. W. Meagher, D. Timmons, S. | Int J Geriatr Psychiatry | 2017 |
cognition |
| Midterm outcomes after postoperative delirium on cognition and mood in patients after cardiac surgery. | Nguyen, Q. Uminski, K. Hiebert, B. M. Tangri, N. Arora, R. C. | Journal of Thoracic and Cardiovascular Surgery | 2017 |
adult |
| The delirium drug scale is associated to delirium incidence in the emergency department. | Nguyen, Patrick Viet-Quoc Pelletier, Lucie Payot, Isabelle Latour, Judith | International Psychogeriatrics | 2017 |
delirium |
| Post-operative delirium is associated with increased 5-year mortality. | Moskowitz, E. E. Overbey, D. M. Jones, T. S. Jones, E. L. Arcomano, T. R. Moore, J. T. Robinson, T. N. | Am J Surg | 2017 |
Aged |
| Worldwide Survey of the "Assessing Pain, Both Spontaneous Awakening and Breathing Trials, Choice of Drugs, Delirium Monitoring/Management, Early Exercise/Mobility, and Family Empowerment" (ABCDEF) Bundle. | Morandi, A. Piva, S. Ely, E. W. Myatra, S. N. Salluh, J. I. F. Amare, D. Azoulay, E. Bellelli, G. Csomos, A. Fan, E. Fagoni, N. Girard, T. D. Heras La Calle, G. Inoue, S. Lim, C. M. Kaps, R. Kotfis, K. Koh, Y. Misango, D. Pandharipande, P. P. Permpikul, C | Crit Care Med | 2017 |
Adult |
| Validation of an automated delirium prediction model (DElirium MOdel (DEMO)): an observational study. | Mestres Gonzalvo, C. de Wit, Hajm van Oijen, B. P. C. Deben, D. S. Hurkens, Kpgm Mulder, W. J. Janknegt, R. Schols, Jmga Verhey, F. R. Winkens, B. van der Kuy, P. M. | BMJ Open | 2017 |
geriatric medicine |
| Peripheral Nerve Block as a Supplement to Light or Deep General Anesthesia in Elderly Patients Receiving Total Hip Arthroplasty: A Prospective Randomized Study. | Mei, B. Zha, H. Lu, X. Cheng, X. Chen, S. Liu, X. Li, Y. Gu, E. | Clin J Pain | 2017 | |
| INTERDEM Academy special section: what effect does delirium have on family and nurses of older adult patients? | Martins, S. Pinho, E. Correia, R. Moreira, E. Lopes, L. Paiva, J. A. Azevedo, L. Fernandes, L. | Aging Ment Health | 2017 |
Delirium |
| Implementing a Multicomponent Intervention to Prevent Delirium Among Critically Ill Patients. | Martinez, F. Donoso, A. M. Marquez, C. Labarca, E. | Crit Care Nurse | 2017 | |
| Health-Care Workers' Judgments About Pain in Older Palliative Care Patients With and Without Delirium. | Mah, K. Rodin, R. A. Chan, V. W. S. Stevens, B. J. Zimmermann, C. Gagliese, L. | Am J Hosp Palliat Care | 2017 |
cancer pain |
| Incidence and Risk Factors of Delirium in Patients After Type-A Aortic Dissection Surgery. | Liu, Z. Pang, X. Zhang, X. Cao, G. Fang, C. Wu, S. | J Cardiothorac Vasc Anesth | 2017 |
delirium |
| Comparison of regional with general anaesthesia on postoperative delirium (RAGA-delirium) in the older patients undergoing hip fracture surgery: Study protocol for a multicentre randomised controlled trial. | Li, T. Yeung, J. Li, J. Zhang, Y. Melody, T. Gao, Y. Wang, Y. Lian, Q. Gao, F. | BMJ Open | 2017 |
NCT02213380 |
| Factors Related to the Severity of Delirium in the Elderly Patients With Infection. | Kuswardhani, R. A. T. Sugi, Y. S. | Gerontol Geriatr Med | 2017 |
delirium |
| Decreasing Delirium through Music (DDM) in critically ill, mechanically ventilated patients in the intensive care unit: study protocol for a pilot randomized controlled trial. | Khan, S. H. Wang, S. Harrawood, A. Martinez, S. Heiderscheit, A. Chlan, L. Perkins, A. J. Tu, W. Boustani, M. Khan, B. | Trials | 2017 |
Critical care |
| Sinai Abbreviated Geriatric Evaluation: Development and Validation of a Practical Test. | Katlic, M. R. Coleman, J. Khan, K. Wozniak, S. E. Abraham, J. H. | Ann Surg | 2017 | |
| Structured interdisciplinary bedside rounds do not reduce length of hospital stay and 28-day re-admission rate among older people hospitalised with acute illness: an Australian study. | Huynh, E. Basic, D. Gonzales, R. Shanley, C. | Aust Health Rev | 2017 |