What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Data-derived subtypes of delirium during critical illness
- Authors
- Potter, K. M. Kennedy, J. N. Onyemekwu, C. Prendergast, N. T. Pandharipande, P. P. Ely, E. W. Seymour, C. Girard, T. D.
- Year
- 2024
- Journal
- EBioMedicine
- Abstract
BACKGROUND: To understand delirium heterogeneity, prior work relied on psychomotor symptoms or risk factors to identify subtypes. Data-driven approaches have used machine learning to identify biologically plausible, treatment-responsive subtypes of other acute illnesses but have not been used to examine delirium. METHODS: We conducted a secondary analysis of a large, multicenter prospective cohort study involving adults in medical or surgical ICUs with respiratory failure or shock who experienced delirium per the Confusion Assessment Method for the ICU. We used data collected before delirium diagnosis in an unsupervised latent class model to identify delirium subtypes and then compared demographics, clinical characteristics, and outcomes between subtypes in the final model. FINDINGS: The 731 patients who developed delirium during critical illness had a median age of 63 [IQR, 54-72] years, a median Sequential Organ Failure Assessment score of 8.0 [6.0-11.0] and 613 [83.4%] were mechanically ventilated at delirium identification. A four-class model best fit the data with 50% of patients in subtype (ST) 1, 18% in subtype 2, 17% in subtype 3, and 14% in subtype 4. Subtype 2-which had more shock and kidney impairment-had the highest mortality (33% [ST2] vs. 17% [ST1], 25% [ST3], and 17% [ST4], p = 0.003). Subtype 4-which received more benzodiazepines and opioids-had the longest duration of delirium (6 days [ST4] vs. 3 [ST1], 4 [ST2], and 3 days [ST3], p < 0.001) and coma (4 days [ST4] vs. 2 [ST1], 1 [ST2], and 2 days [ST3], p < 0.001). Each of the four data-derived delirium subtypes was observed within previously identified psychomotor and risk factor-based delirium subtypes. Clinically significant cognitive impairment affected all subtypes at follow-up, but its severity did not differ by subtype (3-month, p = 0.26; 12-month, p = 0.80). INTERPRETATION: The four data-derived delirium subtypes identified in this study should now be validated in independent cohorts, examined for differential treatment effects in trials, and inform mechanistic work evaluating treatment targets. FUNDING: National Institutes of Health (T32HL007820, R01AG027472).
- PMID
PMID:38169220
PMCID: PMC10797145
- Keywords
Adult
Humans
Middle Aged
Aged
*Delirium/diagnosis/etiology
Prospective Studies
Critical Illness
Interleukin-1 Receptor-Like 1 Protein
*Cognitive Dysfunction/complications
Delirium
Heterogeneity
Latent class analysis
Subtypes
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Incidence and clinical significance of postoperative delirium after brain tumor surgery. | Budenas, A. Tamasauskas, S. Sliauzys, A. Navickaite, I. Sidaraite, M. Pranckeviciene, A. Deltuva, V. P. Tamasauskas, A. Bunevicius, A. | Acta Neurochir (Wien) | 2018 |
Brain tumor |
| Role of perceived stress in postoperative delirium: an investigation among elderly patients. | Banjongrewadee, M. Wongpakaran, N. Wongpakaran, T. Pipanmekaporn, T. Punjasawadwong, Y. Mueankwan, S. | Aging Ment Health | 2018 |
Perceived stress |
| Predictors and Sequelae of Postoperative Delirium in Geriatric Hip Fracture Patients. | Arshi, A. Lai, W. C. Chen, J. B. Bukata, S. V. Stavrakis, A. I. Zeegen, E. N. | Geriatr Orthop Surg Rehabil | 2018 |
delirium |
| Operative and anaesthetic factors influencing on delirium in the intensive care unit: An Analysis of electronic health records. | An, Y. S. Jin, Y. Jin, T. Hur, E. Y. Lee, S. M. | J Clin Nurs | 2018 |
delirium |
| Effect of anticholinergic burden on treatment modification, delirium and mortality in newly diagnosed dementia patients starting a cholinesterase inhibitor: a population-based study. | Ah, Y. M. Suh, Y. Jun, K. Hwang, S. Lee, J. Y. | Basic Clin Pharmacol Toxicol | 2018 |
Alzheimer’s disease |
| Postoperative Delirium in Individuals Undergoing Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis. | Abawi, M. Pagnesi, M. Agostoni, P. Chiarito, M. van Jaarsveld, R. C. van Dongen, C. S. Slooter, A. J. C. Colombo, A. Kooistra, N. H. M. Doevendans, Pafm Latib, A. Stella, P. R. | J Am Geriatr Soc | 2018 |
Tavr |
| Effect of goal-directed fluid therapy on early cognitive function in elderly patients with spinal stenosis: A Case-Control Study. | Zhang, N. Liang, M. Zhang, D. D. Xiao, Y. R. Li, Y. Z. Gao, Y. G. Cai, H. D. Lin, X. Z. Lin, C. Z. Zeng, K. Wu, X. D. | Int J Surg | 2018 |
Elderly patients |
| Rehospitalization following a stay in geriatric rehabilitation wards: rates and predictive factors. | Tardivel, M. Muller, F. Tortrat, D. Lechowski, L. Teillet, L. | Geriatr Psychol Neuropsychiatr Vieil | 2018 |
geriatric post-acute and rehabilitation care wards |
| Elimination of Routine Benzodiazepine Administration for Nonprocedural Sedation in a Trauma Intensive Care Unit Is Feasible. | McGinn, K. Davis, S. N. Terrry, E. Simmons, J. Brevard, S. | Am Surg | 2018 |
Adult |
| Can Chaotic Analysis of Electroencephalogram Aid the Diagnosis of Encephalopathy? | Jacob, J. E. Cherian, A. Gopakumar, K. Iype, T. Yohannan, D. G. Divya, K. P. | Neurology Research International | 2018 |
adult |
| Hospital outcomes of older people with cognitive impairment: An integrative review. | Fogg, C. Griffiths, P. Meredith, P. Bridges, J. | Int J Geriatr Psychiatry | 2018 |
cognitive dysfunction |
| Physostigmine is superior to non-antidote therapy in the management of antimuscarinic delirium: a prospective study from a regional poison center. | Boley, S. P. Olives, T. D. Bangh, S. A. Fahrner, S. Cole, J. B. | Clin Toxicol | 2018 |
Physostigmine |
| Cholinesterase inhibitors for the treatment of delirium in non-ICU settings. | Yu, A. Wu, S. Zhang, Z. Dening, T. Zhao, S. Pinner, G. Xia, J. Yang, D. | Cochrane Database of Systematic Reviews | 2018 | |
| Perioperative dexmedetomidine reduces delirium after cardiac surgery: A meta-analysis of randomized controlled trials | Wu, M. Liang, Y. Dai, Z. Wang, S. | J Clin Anesth | 2018 |
Cardiac surgery |
| Diabetes and Glucose Dysregulation and Transition to Delirium in ICU Patients. | van Keulen, K. Knol, W. Belitser, S. V. van der Linden, P. D. Heerdink, E. R. Egberts, T. C. G. Slooter, A. J. C. | Crit Care Med | 2018 | |
| Factors associated with delirium in critical patients in a health institution in Bucaramanga, Colombia. | Torres-Contreras, C. C. Paez-Esteban, A. N. Hinestrosa-Diaz Del Castillo, A. Rincon-Romero, M. K. Amaris-Vega, A. Martinez-Patino, J. P. | Enferm Intensiva | 2018 |
Delirium |
| The effect of preoperative cognitive impairment and type of vascular surgery procedure on postoperative delirium with associated cost implications. | Styra, R. Larsen, E. Dimas, M. A. Baston, D. Elgie-Watson, J. Flockhart, L. Lindsay, T. F. | J Vasc Surg | 2018 |
Cognition |
| Rate and risk factors for a hyperactivity delirium in patients with aneurysmal subarachnoid haemorrhage. | Sauvigny, T. Mohme, M. Grensemann, J. Duhrsen, L. Regelsberger, J. Kluge, S. Schmidt, N. O. Westphal, M. Czorlich, P. | Neurosurg Rev | 2018 |
Delirium |
| Delirium in Postoperative Patients Admitted to the Intensive Care Unit. | Romanauski, T. R. Martin, E. E. Sprung, J. Martin, D. P. Schroeder, D. R. Weingarten, T. N. | Am Surg | 2018 |
Adult |
| Degree of implementation of preventive strategies for post-ICU syndrome: Multi-centre, observational study in Spain. | Raurell-Torreda, M. Arias-Rivera, S. Marti, J. D. Frade-Mera, M. J. Zaragoza-Garcia, I. Gallart, E. Velasco-Sanz, T. R. San Jose-Arribas, A. Blazquez-Martinez, E. | Enferm Intensiva | 2018 |
Critical illness |
| Surgical delay is a risk factor of delirium in hip fracture patients with mild-moderate cognitive impairment. | Pioli, G. Bendini, C. Giusti, A. Pignedoli, P. Cappa, M. Iotti, E. Ferri, M. A. Bergonzini, E. Sabetta, E. | Aging Clin Exp Res | 2018 |
Delirium |
| Predictors of Delirium Development in Older Medical Inpatients: Readily Identifiable Factors at Admission. | O’Regan, Niamh A. Fitzgerald, James Adamis, Dimitrios Molloy, David William Meagher, David Timmons, Suzanne Montero-Odasso, Manuel | Journal of Alzheimer's Disease | 2018 | |
| Processed Electroencephalogram Monitoring and Postoperative Delirium: A Systematic Review and Meta-analysis. | MacKenzie, K. K. Britt-Spells, A. M. Sands, L. P. Leung, J. M. | Anesthesiology | 2018 | |
| The influence of oxygen delivery during cardiopulmonary bypass on the incidence of delirium in CABG patients; a retrospective study | Leenders, J. Overdevest, E. van Straten, B. Golab, H. | Perfusion | 2018 |
Cabg |
| Safety of brotizolam in hospitalized patients. | Lavon, O. Bejel, S. | European Journal of Clinical Pharmacology | 2018 |
benzodiazepine derivative |
| Early delirium after cardiac surgery: An analysis of incidence and risk factors in elderly (≥65 years) and very elderly (≥80 years) patients. | Kotfis, K. Szylińska, A. Listewnik, M. Strzelbicka, M. Brykczyński, M. Rotter, I. Żukowski, M. | Clinical Interventions in Aging | 2018 |
creatinine |
| ICU delirium - a diagnostic and therapeutic challenge in the intensive care unit. | Kotfis, K. Marra, A. Ely, E. W. | Anaesthesiol Intensive Ther | 2018 |
Cam-icu |
| Melatonin and sleep in preventing hospitalized delirium: A randomized clinical trial. | Jaiswal, S. J. McCarthy, T. J. Wineinger, N. E. Kang, D. Y. Song, J. Garcia, S. van Niekerk, C. J. Lu, C. Y. Loeks, M. Owens, R. L. | Am J Med | 2018 |
Delirium |
| Intraoperative ketamine administration to prevent delirium or postoperative cognitive dysfunction: A systematic review and meta-analysis. | Hovaguimian, F. Tschopp, C. Beck-Schimmer, B. Puhan, M. | Acta Anaesthesiol Scand | 2018 |
cognitive dysfunction |
| The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses. | Hov, K. R. Neerland, B. E. Andersen, A. M. Undseth, O. Wyller, V. B. MacLullich, A. M. J. Skovlund, E. Qvigstad, E. Wyller, T. B. | BMC Pharmacol Toxicol | 2018 |
Clonidine |
| Delirium's Arousal Subtypes and Their Relationship with 6-Month Functional Status and Cognition. | Han, J. H. Hayhurst, C. J. Chandrasekhar, R. Hughes, C. G. Vasilevskis, E. E. Wilson, J. E. Schnelle, J. F. Dittus, R. S. Ely, E. W. | Psychosomatics | 2018 |
aged |
| Intraoperative electroencephalogram suppression at lower volatile anaesthetic concentrations predicts postoperative delirium occurring in the intensive care unit. | Fritz, B. A. Maybrier, H. R. Avidan, M. S. | British Journal of Anaesthesia | 2018 |
NCT02032030 |
| Efficacy of perioperative dexmedetomidine on postoperative delirium: systematic review and meta-analysis with trial sequential analysis of randomised controlled trials. | Duan, X. Coburn, M. Rossaint, R. Sanders, R. D. Waesberghe, J. V. Kowark, A. | British Journal of Anaesthesia | 2018 |
adult |
| Long-term sequelae of acute respiratory distress syndrome caused by severe community-acquired pneumonia: Delirium-associated cognitive impairment and post-traumatic stress disorder. | Denke, C. Balzer, F. Menk, M. Szur, S. Brosinsky, G. Tafelski, S. Wernecke, K. D. Deja, M. | J Int Med Res | 2018 |
Community-acquired pneumonia |
| A Performing Arts Intervention Improves Cognitive Dysfunction in 50 Hospitalized Older Adults. | Danila, M. I. Melnick, J. A. Mudano, A. Flood, K. Booth, K. Kirklin, K. Saag, K. G. | Innov Aging | 2018 |
Alternative and complementary medicine/care/therapy |
| Nursing perspectives on the confusion assessment method: a qualitative focus group study. | Wong, E. K. Lee, J. Y. Surendran, A. S. Nair, K. Della Maestra, N. Migliarini, M. St Onge, J. A. Patterson, C. J. | Age Ageing | 2018 | |
| Detection and management of hyperactive and hypoactive delirium in older patients during hospitalization: a retrospective cohort study evaluating daily practice. | van Velthuijsen, E. L. Zwakhalen, S. M. G. Mulder, W. J. Verhey, F. R. J. Kempen, Gijm | Int J Geriatr Psychiatry | 2018 |
care as usual |
| Glucose variability during delirium in diabetic and non-diabetic intensive care unit patients: A prospective cohort study. | van Keulen, K. Knol, W. Belitser, S. V. Zaal, I. J. van der Linden, P. D. Heerdink, E. R. Egberts, T. C. G. Slooter, A. J. C. | PLoS One | 2018 | |
| Evaluating the use of dexmedetomidine for the reduction of delirium: An integrative review. | Pavone, K. J. Cacchione, P. Z. Polomano, R. C. Winner, L. Compton, P. | Heart Lung | 2018 |
Delirium |
| Delirium Monitoring in Neurocritically Ill Patients: A Systematic Review. | Patel, M. B. Bednarik, J. Lee, P. Shehabi, Y. Salluh, J. I. Slooter, A. J. Klein, K. E. Skrobik, Y. Morandi, A. Spronk, P. E. Naidech, A. M. Pun, B. T. Bozza, F. A. Marra, A. John, S. Pandharipande, P. P. Ely, E. W. | Crit Care Med | 2018 | |
| Poststroke Delirium Clinical Motor Subtypes: The PRospective Observational POLIsh Study (PROPOLIS). | Pasinska, P. Kowalska, K. Klimiec, E. Wilk, A. Szyper-Maciejowska, A. Dziedzic, T. Klimkowicz-Mrowiec, A. | J Neuropsychiatry Clin Neurosci | 2018 |
Delirium |
| A systematic review of neuroimaging in delirium: predictors, correlates and consequences. | Nitchingham A, Kumar V, Shenkin S, Ferguson KJ, Caplan GA | International journal of geriatric psychiatry | 2017 |
delirium |
| The effect of dexmedetomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis. | Ng, K. T. Shubash, C. J. Chong, J. S. | Anaesthesia | 2018 |
adult |
| A Point Prevalence Study of Delirium in Italian Nursing Homes. | Morichi, V. Fedecostante, M. Morandi, A. Di Santo, S. G. Mazzone, A. Mossello, E. Bo, M. Bianchetti, A. Rozzini, R. Zanetti, E. Musicco, M. Ferrari, A. Ferrara, N. Trabucchi, M. Cherubini, A. Bellelli, G. | Dementia and Geriatric Cognitive Disorders | 2018 |
neuroleptic agent |
| Increased Readmission Risk and Healthcare Cost for Delirium Patients without Immediate Hospitalization in the Emergency Department. | Ma, I. C. Chen, K. C. Chen, W. T. Tsai, H. C. Su, C. C. Lu, R. B. Chen, P. S. Chang, W. H. Yang, Y. K. | Clin Psychopharmacol Neurosci | 2018 |
Delirium |
| The effect of chronotherapy on delirium in critical care - a systematic review. | Luther R, McLeod A | Nursing in critical care | 2017 |
Adult intensive care |
| Intraoperative use of dexmedetomidine for the prevention of emergence agitation and postoperative delirium in thoracic surgery: a randomized-controlled trial. | Kim, J. A. Ahn, H. J. Yang, M. Lee, S. H. Jeong, H. Seong, B. G. | Canadian Journal of Anesthesia | 2019 |
adult |
| Delirium following total joint replacement surgery. | Huang, J. Sprung, J. Weingarten, T. N. | Bosn J Basic Med Sci | 2019 | |
| Delirium management: Let's get physical? A systematic review and meta-analysis. | Haley, M. N. Casey, P. Kane, R. Y. Darzins, P. Lawler, K. | Australas J Ageing | 2019 |
delirium |
| Increasing Light Exposure for the Prevention of Delirium: A Systematic Review. | Groves, R. L. | Dimensions of Critical Care Nursing | 2019 |
adult |
| Perioperative Risk Factors for Postoperative Delirium in Patients Undergoing Esophagectomy. | Fuchita, M. Khan, S. H. Perkins, A. J. Gao, S. Wang, S. Kesler, K. A. Khan, B. A. | Ann Thorac Surg | 2019 | |
| Delirium and Alzheimer's Disease: A Proposed Model for Shared Pathophysiology. | Fong, T. G. Vasunilashorn, S. M. Libermann, T. Marcantonio, E. R. Inouye, S. K. | Int J Geriatr Psychiatry | 2019 |
biomarkers |
| Diagnostic Performance and Utility of Quantitative EEG Analyses in Delirium: Confirmatory Results From a Large Retrospective Case-Control Study. | Fleischmann, R. Tränkner, S. Bathe-Peters, R. Rönnefarth, M. Schmidt, S. Schreiber, S. J. Brandt, S. A. | Clinical EEG and Neuroscience | 2019 |
electroencephalograph |
| Differences in potential biomarkers of delirium between acutely ill medical and elective cardiac surgery patients. | Egberts, A. Osse, R. J. Fekkes, D. Tulen, J. H. M. van der Cammen, T. J. M. Mattace-Raso, F. U. S. | Clin Interv Aging | 2019 |
delirium |
| Translation and validation of the tibetan confusion assessment method for the intensive care unit (CAM-ICU). | Danzeng, Q. Z. Cui, N. Wang, H. Pan, W. J. Long, Y. Deji, Y. Z. Ze, C. Ren, Z. | Chin Med J (Engl) | 2019 | |
| Intra-operative Blood Transfusion Predicts Post-Operative Delirium among Older Patients Undergoing Elective Orthopedic Surgery: a Prospective Cohort Study. | Chou, M. Y. Wang, Y. C. Peng, L. N. Liang, C. K. Chu, C. S. Liao, M. C. Lin, Y. T. Hsu, C. J. Chen, L. K. | Int J Geriatr Psychiatry | 2019 |
a |
| Vitamin D levels and risk of delirium: A mendelian randomization study in the UK Biobank | Bowman, K. Jones, L. Pilling, L. C. Delgado, J. Kuchel, G. A. Ferrucci, L. Fortinsky, R. H. Melzer, D. | Neurology | 2019 | |
| Pharmacological interventions for prevention and management of delirium in intensive care patients: A systematic overview of reviews and meta-analyses. | Barbateskovic, M. Krauss, S. R. Collet, M. O. Larsen, L. K. Jakobsen, J. C. Perner, A. Wetterslev, J. | BMJ Open | 2019 |
CRD42016046628 |
| Pre-operative biomarkers and imaging tests as predictors of post-operative delirium in non-cardiac surgical patients: a systematic review. | Ayob, F. Lam, E. Ho, G. Chung, F. El-Beheiry, H. Wong, J. | BMC Anesthesiology | 2019 |
Post-operative delirium |
| Training interventions to improve general hospital care for older people with cognitive impairment: systematic review. | Abley, C. Dickinson, C. Andrews, Z. Prato, L. Lindley, L. Robinson, L. | Br J Psychiatry | 2019 |
Dementia |
| Cognitive impairment and postoperative outcomes in patients undergoing primary total hip arthroplasty: A systematic review. | Viramontes, O. Luan Erfe, B. M. Erfe, J. M. Brovman, E. Y. Boehme, J. Bader, A. M. Urman, R. D. | J Clin Anesth | 2019 |
Anesthesia |
| Autonomic cardiovascular control in older patients with acute infection and delirium: a pilot study of orthostatic stress responses. | Neerland, B. E. Wyller, T. B. Wyller, V. B. B. | BMC Geriatr | 2019 |
Autonomic function |
| The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy - A prospective, pilot observational study. | Ehler, J. Petzold, A. Wittstock, M. Kolbaske, S. Gloger, M. Henschel, J. Heslegrave, A. Zetterberg, H. Lunn, M. P. Rommer, P. S. Grossmann, A. Sharshar, T. Richter, G. Noldge-Schomburg, G. Sauer, M. | PLoS One | 2019 | |
| A systematic review of interventions to facilitate extubation in patients difficult-to-wean due to delirium, agitation, or anxiety and a meta-analysis of the effect of dexmedetomidine. | Dupuis, S. Brindamour, D. Karzon, S. Frenette, A. J. Charbonney, E. Perreault, M. M. Bellemare, P. Burry, L. Williamson, D. R. | Can J Anaesth | 2019 | |
| Haloperidol for the management of delirium in adult intensive care unit patients: A systematic review and meta-analysis of randomized controlled trials. | Zayed, Y. Barbarawi, M. Kheiri, B. Banifadel, M. Haykal, T. Chahine, A. Rashdan, L. Aburahma, A. Bachuwa, G. Seedahmed, E. | J Crit Care | 2019 |
Critically ill patients |
| Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study. | Westphal, S. Stoppe, C. Gruenewald, M. Bein, B. Renner, J. Cremer, J. Coburn, M. Schaelte, G. Boening, A. Niemann, B. Kletzin, F. Roesner, J. Strouhal, U. Reyher, C. Laufenberg-Feldmann, R. Ferner, M. Brandes, I. F. Bauer, M. Kortgen, A. Stehr, S. N. Witt | BMC Cardiovasc Disord | 2019 |
Acute kidney injury |
| Preoperative Anxiety as a Predictor of Delirium in Cancer Patients: A Prospective Observational Cohort Study. | Wada, S. Inoguchi, H. Sadahiro, R. Matsuoka, Y. J. Uchitomi, Y. Sato, T. Shimada, K. Yoshimoto, S. Daiko, H. Shimizu, K. | World J Surg | 2019 | |
| Development of a Dynamic Multi-Protein Signature of Postoperative Delirium. | Vasunilashorn, S. M. Ngo, L. H. Chan, N. Y. Zhou, W. Dillon, S. T. Otu, H. H. Inouye, S. K. Wyrobnik, I. Kuchel, G. A. McElhaney, J. E. Xie, Z. Alsop, D. C. Jones, R. N. Libermann, T. A. Marcantonio, E. R. | J Gerontol A Biol Sci Med Sci | 2019 | |
| Improved Guideline Adherence and Reduced Brain Dysfunction After a Multicenter Multifaceted Implementation of ICU Delirium Guidelines in 3,930 Patients. | Trogrlic, Z. van der Jagt, M. Lingsma, H. Gommers, D. Ponssen, H. H. Schoonderbeek, J. F. J. Schreiner, F. Verbrugge, S. J. Duran, S. Bakker, J. Ista, E. | Crit Care Med | 2019 | |
| Trajectory of severity of postoperative delirium symptoms and its prospective association with cognitive function in patients with gastric cancer: results from a prospective observational study. | Shim, E. J. Noh, H. L. Lee, K. M. Hwang, H. Son, K. L. Jung, D. Kim, W. H. Kong, S. H. Suh, Y. S. Lee, H. J. Yang, H. K. Hahm, B. J. | Support Care Cancer | 2019 |
Anesthesia |
| Sedation Variability Increases Incidence of Delirium in Adult Medical Intensive Care Unit Patients at a Tertiary Academic Medical Center. | Ritchie, B. M. Torbic, H. DeGrado, J. R. Reardon, D. P. | Am J Ther | 2019 | |
| Current Pharmacotherapy Does Not Improve Severity of Hypoactive Delirium in Patients with Advanced Cancer: Pharmacological Audit Study of Safety and Efficacy in Real World (Phase-R). | Okuyama, T. Yoshiuchi, K. Ogawa, A. Iwase, S. Yokomichi, N. Sakashita, A. Tagami, K. Uemura, K. Nakahara, R. Akechi, T. | Oncologist | 2019 |
Antipsychotic agents |
| Quality of care in hospitalized cancer patients before and after implementation of a systematic prevention program for delirium: the DELTA exploratory trial. | Ogawa, A. Okumura, Y. Fujisawa, D. Takei, H. Sasaki, C. Hirai, K. Kanno, Y. Higa, K. Ichida, Y. Sekimoto, A. Asanuma, C. | Supportive Care in Cancer | 2019 |
benzodiazepine derivative |
| Relevance of peripheral cholinesterase activity on postoperative delirium in adult surgical patients (CESARO): A prospective observational cohort study. | Müller, A. Olbert, M. Heymann, A. Zahn, P. K. Plaschke, K. von Dossow, V. Bitzinger, D. Barth, E. Meister, M. Kranke, P. Herrmann, C. Wernecke, K. D. Spies, C. D. | European Journal of Anaesthesiology | 2019 |
NCT01964274 |
| Predicting postoperative delirium and postoperative cognitive decline with combined intraoperative electroencephalogram monitoring and cerebral near-infrared spectroscopy in patients undergoing cardiac interventions. | Momeni, M. Meyer, S. Docquier, M. A. Lemaire, G. Kahn, D. Khalifa, C. Rosal Martins, M. Van Dyck, M. Jacquet, L. M. Peeters, A. Watremez, C. | J Clin Monit Comput | 2019 |
Burst suppression |
| Early Postoperative Actigraphy Poorly Predicts Hypoactive Delirium. | Maybrier, H. R. King, C. R. Crawford, A. E. Mickle, A. M. Emmert, D. A. Wildes, T. S. Avidan, M. S. Palanca, B. J. A. | J Clin Sleep Med | 2019 |
actigraphy |
| Subsyndromal delirium is associated with poor functional outcome after ischemic stroke. | Klimiec, E. Lis, A. Pera, J. Slowik, A. Dziedzic, T. | Eur J Neurol | 2019 |
confusion |
| Pharmacological Management of Delirium in the Intensive Care Unit: A Randomized Pragmatic Clinical Trial. | Khan, B. A. Perkins, A. J. Campbell, N. L. Gao, S. Farber, M. O. Wang, S. Khan, S. H. Zarzaur, B. L. Boustani, M. A. | J Am Geriatr Soc | 2019 |
benzodiazepine |
| Use of medicines that may precipitate delirium prior to hospitalisation in older Australians with delirium: An observational study. | Kassie, G. M. Kalisch Ellett, L. M. Nguyen, T. A. Roughead, E. E. | Australas J Ageing | 2019 |
delirium |
| Comprehensive risk factor evaluation of postoperative delirium following major surgery: clinical data warehouse analysis. | Kang, S. Y. Seo, S. W. Kim, J. Y. | Neurol Sci | 2019 |
Clinical data warehouse |
| Lower risk of postoperative delirium using laparoscopic approach for major abdominal surgery. | Ito, K. Suka, Y. Nagai, M. Kawasaki, K. Yamamoto, M. Koike, D. Nomura, Y. Tanaka, N. Kawaguchi, Y. | Surg Endosc | 2019 |
Laparoscopic approach |
| Delirium is associated with frequency band specific dysconnectivity in intrinsic connectivity networks: preliminary evidence from a large retrospective pilot case-control study. | Fleischmann, R. Traenkner, S. Kraft, A. Schmidt, S. Schreiber, S. J. Brandt, S. A. | Pilot Feasibility Stud | 2019 |
Biomarker |
| Risk Factors Associated With Postoperative Delirium in Patients Undergoing Head and Neck Free Flap Reconstruction. | Densky, J. Eskander, A. Kang, S. Chan, J. Tweel, B. Sitapara, J. Ozer, E. Agrawal, A. Carrau, R. Rocco, J. Teknos, T. N. Old, M. | JAMA Otolaryngol Head Neck Surg | 2019 | |
| Deprescribing in the Pharmacologic Management of Delirium: A Randomized Trial in the Intensive Care Unit. | Campbell, N. L. Perkins, A. J. Khan, B. A. Gao, S. Farber, M. O. Khan, S. Wang, S. Boustani, M. A. | J Am Geriatr Soc | 2019 |
anticholinergic |
| Reliability of mobility measures in older medical patients with cognitive impairment. | Braun, T. Thiel, C. Schulz, R. J. Gruneberg, C. | BMC Geriatr | 2019 |
Cognitive impairment |
| Effectiveness of Melatonin for the Prevention of Intensive Care Unit Delirium. | Baumgartner, L. Lam, K. Lai, J. Barnett, M. Thompson, A. Gross, K. Morris, A. | Pharmacotherapy | 2019 |
Delirium |
| Validation of the Prediction of Delirium for Intensive Care model to predict subsyndromal delirium. | Azuma, K. Mishima, S. Shimoyama, K. Ishii, Y. Ueda, Y. Sakurai, M. Morinaga, K. Fujikawa, T. Oda, J. | Acute Med Surg | 2019 |
Critical care |
| Association Between Postoperative Delirium and Long-term Cognitive Function After Major Nonemergent Surgery. | Austin, C. A. O'Gorman, T. Stern, E. Emmett, D. Sturmer, T. Carson, S. Busby-Whitehead, J. | JAMA Surg | 2019 | |
| 'I hope you get normal again': an explorative study on how delirious octogenarian patients experience their interactions with healthcare professionals and relatives after aortic valve therapy. | Instenes, I. Fridlund, B. Amofah, H. A. Ranhoff, A. H. Eide, L. S. Norekval, T. M. | Eur J Cardiovasc Nurs | 2018 |
Delirium |
| Establishing a successful perioperative geriatric service in an Australian acute surgical unit. | Styan, L. Murphy, S. Fleury, A. McGowan, B. Wullschleger, M. | ANZ Journal of Surgery | 2018 |
aged |
| Delirium and Antipsychotic Medications at Hospital Intake: Screening to Decrease Likelihood of Aggression in Inpatient Settings Among Unknown Patients With Dementia. | Wharton, T. Paulson, D. Burcher, K. Lesch, H. | Am J Alzheimers Dis Other Demen | 2018 |
behavior |
| Preoperative assessment of frailty predicts age-related events after hepatic resection: a prospective multicenter study. | Tanaka, S. Ueno, M. Iida, H. Kaibori, M. Nomi, T. Hirokawa, F. Ikoma, H. Nakai, T. Eguchi, H. Kubo, S. | J Hepatobiliary Pancreat Sci | 2018 |
Age Factors |
| Efficacy and Tolerability of Atypical Antipsychotics in the Treatment of Delirium: A Systematic Review of the Literature. | Rivière, J. van der Mast, R. C. Vandenberghe, J. Van Den Eede, F. | Psychosomatics | 2018 |
aged |
| Outcomes of Prehospital Chemical Sedation With Ketamine Versus Haloperidol and Benzodiazepine or Physical Restraint Only. | O'Connor, L. Rebesco, M. Robinson, C. Gross, K. Castellana, A. O'Connor, M. J. Restuccia, M. | Preshosp Emerg Care | 2018 |
agitated delirium |
| Just another piece of paperwork": perceptions of clinicians on delirium screening following hip fracture repair elicited in focus groups. | Oberai, T. Killington, M. Laver, K. Crotty, M. Jaarsma, R. | Int Psychogeriatr | 2018 |
aging |
| Altered mental status predicts mortality in cardiogenic shock – results from the CardShock study. | Kataja, A. Tarvasmäki, T. Lassus, J. Køber, L. Sionis, A. Spinar, J. Parissis, J. Carubelli, V. Cardoso, J. Banaszewski, M. Marino, R. Nieminen, M. S. Mebazaa, A. Harjola, V. P. | European Heart Journal: Acute Cardiovascular Care | 2018 |
NCT01374867 |
| Nurses' and physicians' approaches to delirium management in the intensive care unit: A focus group investigation. | Collet, M. O. Thomsen, T. Egerod, I. | Aust Crit Care | 2018 |
Delirium |
| Low Plasma Cholinesterase Activity is Associated With Postoperative Delirium After Noncardiac Surgery in Elderly Patients: A Prospective Observational Study. | Zhao, B. Ni, Y. Tian, X. | Psychosomatics | 2018 |
aged |
| Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults. | Zhang, Y. Shan, G. J. Zhang, Y. X. Cao, S. J. Zhu, S. N. Li, H. J. Ma, D. Wang, D. X. | British Journal of Anaesthesia | 2018 |
ChiCTR-IPR-15006209 |
| Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery. | Xie, S. Xie, M. | Pak J Pharm Sci | 2018 |