What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients (Review)
- Authors
- Burton JK, Craig LE, Yong SQ, Siddiqi N, Teale EA, Woodhouse R, Barugh AJ, Shepherd AM, Brunton A, Freeman SC, Sutton AJ, Quinn TJ
- Year
- 2021
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is an acute neuropsychological disorder that is common in hospitalised patients. It can be distressing to patients and carers and it is associated with serious adverse outcomes. Treatment options for established delirium are limited and so prevention of delirium is desirable. Non-pharmacological interventions are thought to be important in delirium prevention. OBJECTIVES: To assess the effectiveness of non-pharmacological interventions designed to prevent delirium in hospitalised patients outside intensive care units (ICU).
Search methods: We searched ALOIS, the specialised register of the Cochrane Dementia and Cognitive Improvement Group, with additional searches conducted in MEDLINE, Embase, PsycINFO, CINAHL, LILACS, Web of Science Core Collection, ClinicalTrials.gov and the World Health Organization Portal/ICTRP to 16 September 2020. There were no language or date restrictions applied to the electronic searches, and no methodological filters were used to restrict the search.
Selection criteria: We included randomised controlled trials (RCTs) of single and multicomponent non-pharmacological interventions for preventing delirium in hospitalised adults cared for outside intensive care or high dependency settings. We only included non-pharmacological interventions which were designed and implemented to prevent delirium. DATA COLLECTION AND ANALYSIS: Two review authors independently examined titles and abstracts identified by the search for eligibility and extracted data from full-text articles. Any disagreements on eligibility and inclusion were resolved by consensus. We used standard Cochrane methodological procedures. The primary outcomes were: incidence of delirium; inpatient and later mortality; and new diagnosis of dementia. We included secondary and adverse outcomes as pre-specified in the review protocol. We used risk ratios (RRs) as measures of treatment effect for dichotomous outcomes and between-group mean differences for continuous outcomes. The certainty of the evidence was assessed using GRADE. A complementary exploratory analysis was undertaker using a Bayesian component network meta-analysis fixed-effect model to evaluate the comparative effectiveness of the individual components of multicomponent interventions and describe which components were most strongly associated with reducing the incidence of delirium.
Main results: We included 22 RCTs that recruited a total of 5718 adult participants. Fourteen trials compared a multicomponent delirium prevention intervention with usual care. Two trials compared liberal and restrictive blood transfusion thresholds. The remaining six trials each investigated a different non-pharmacological intervention. Incidence of delirium was reported in all studies. Using the Cochrane risk of bias tool, we identified risks of bias in all included trials. All were at high risk of performance bias as participants and personnel were not blinded to the interventions. Nine trials were at high risk of detection bias due to lack of blinding of outcome assessors and three more were at unclear risk in this domain. Pooled data showed that multi-component non-pharmacological interventions probably reduce the incidence of delirium compared to usual care (10.5% incidence in the intervention group, compared to 18.4% in the control group, risk ratio (RR) 0.57, 95% confidence interval (CI) 0.46 to 0.71, I2 = 39%; 14 studies; 3693 participants; moderate-certainty evidence, downgraded due to risk of bias). There may be little or no effect of multicomponent interventions on inpatient mortality compared to usual care (5.2% in the intervention group, compared to 4.5% in the control group, RR 1.17, 95% CI 0.79 to 1.74, I2 = 15%; 10 studies; 2640 participants; low-certainty evidence downgraded due to inconsistency and imprecision). No studies of multicomponent interventions reported data on new diagnoses of dementia. Multicomponent interventions may result in a small reduction of around a day in the duration of a delirium episode (mean difference (MD) -0.93, 95% CI -2.01 to 0.14 days, I2 = 65%; 351 participants; low-certainty evidence downgraded due to risk of bias and imprecision). The evidence is very uncertain about the effect of multicomponent interventions on delirium severity (standardised mean difference (SMD) -0.49, 95% CI -1.13 to 0.14, I2=64%; 147 participants; very low-certainty evidence downgraded due to risk of bias and serious imprecision). Multicomponent interventions may result in a reduction in hospital length of stay compared to usual care (MD -1.30 days, 95% CI -2.56 to -0.04 days, I2=91%; 3351 participants; low-certainty evidence downgraded due to risk of bias and inconsistency), but little to no difference in new care home admission at the time of hospital discharge (RR 0.77, 95% CI 0.55 to 1.07; 536 participants; low-certainty evidence downgraded due to risk of bias and imprecision). Reporting of other adverse outcomes was limited. Our exploratory component network meta-analysis found that re-orientation (including use of familiar objects), cognitive stimulation and sleep hygiene were associated with reduced risk of incident delirium. Attention to nutrition and hydration, oxygenation, medication review, assessment of mood and bowel and bladder care were probably associated with a reduction in incident delirium but estimates included the possibility of no benefit or harm. Reducing sensory deprivation, identification of infection, mobilisation and pain control all had summary estimates that suggested potential increases in delirium incidence, but the uncertainty in the estimates was substantial. Evidence from two trials suggests that use of a liberal transfusion threshold over a restrictive transfusion threshold probably results in little to no difference in incident delirium (RR 0.92, 95% CI 0.62 to 1.36; I2 = 9%; 294 participants; moderate-certainty evidence downgraded due to risk of bias). Six other interventions were examined, but evidence for each was limited to single studies and we identified no evidence of delirium prevention. AUTHORS’ CONCLUSIONS: There is moderate-certainty evidence regarding the benefit of multicomponent non-pharmacological interventions for the prevention of delirium in hospitalised adults, estimated to reduce incidence by 43% compared to usual care. We found no evidence of an effect on mortality. There is emerging evidence that these interventions may reduce hospital length of stay, with a trend towards reduced delirium duration, although the effect on delirium severity remains uncertain. Further research should focus on implementation and detailed analysis of the components of the interventions to support more effective, tailored practice recommendations.
- PMID
- Keywords
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Worldwide Survey of the "Assessing Pain, Both Spontaneous Awakening and Breathing Trials, Choice of Drugs, Delirium Monitoring/Management, Early Exercise/Mobility, and Family Empowerment" (ABCDEF) Bundle. | Morandi, A. Piva, S. Ely, E. W. Myatra, S. N. Salluh, J. I. F. Amare, D. Azoulay, E. Bellelli, G. Csomos, A. Fan, E. Fagoni, N. Girard, T. D. Heras La Calle, G. Inoue, S. Lim, C. M. Kaps, R. Kotfis, K. Koh, Y. Misango, D. Pandharipande, P. P. Permpikul, C | Crit Care Med | 2017 |
Adult |
| Validation of an automated delirium prediction model (DElirium MOdel (DEMO)): an observational study. | Mestres Gonzalvo, C. de Wit, Hajm van Oijen, B. P. C. Deben, D. S. Hurkens, Kpgm Mulder, W. J. Janknegt, R. Schols, Jmga Verhey, F. R. Winkens, B. van der Kuy, P. M. | BMJ Open | 2017 |
geriatric medicine |
| Peripheral Nerve Block as a Supplement to Light or Deep General Anesthesia in Elderly Patients Receiving Total Hip Arthroplasty: A Prospective Randomized Study. | Mei, B. Zha, H. Lu, X. Cheng, X. Chen, S. Liu, X. Li, Y. Gu, E. | Clin J Pain | 2017 | |
| INTERDEM Academy special section: what effect does delirium have on family and nurses of older adult patients? | Martins, S. Pinho, E. Correia, R. Moreira, E. Lopes, L. Paiva, J. A. Azevedo, L. Fernandes, L. | Aging Ment Health | 2017 |
Delirium |
| Implementing a Multicomponent Intervention to Prevent Delirium Among Critically Ill Patients. | Martinez, F. Donoso, A. M. Marquez, C. Labarca, E. | Crit Care Nurse | 2017 | |
| Health-Care Workers' Judgments About Pain in Older Palliative Care Patients With and Without Delirium. | Mah, K. Rodin, R. A. Chan, V. W. S. Stevens, B. J. Zimmermann, C. Gagliese, L. | Am J Hosp Palliat Care | 2017 |
cancer pain |
| Incidence and Risk Factors of Delirium in Patients After Type-A Aortic Dissection Surgery. | Liu, Z. Pang, X. Zhang, X. Cao, G. Fang, C. Wu, S. | J Cardiothorac Vasc Anesth | 2017 |
delirium |
| Comparison of regional with general anaesthesia on postoperative delirium (RAGA-delirium) in the older patients undergoing hip fracture surgery: Study protocol for a multicentre randomised controlled trial. | Li, T. Yeung, J. Li, J. Zhang, Y. Melody, T. Gao, Y. Wang, Y. Lian, Q. Gao, F. | BMJ Open | 2017 |
NCT02213380 |
| Factors Related to the Severity of Delirium in the Elderly Patients With Infection. | Kuswardhani, R. A. T. Sugi, Y. S. | Gerontol Geriatr Med | 2017 |
delirium |
| Decreasing Delirium through Music (DDM) in critically ill, mechanically ventilated patients in the intensive care unit: study protocol for a pilot randomized controlled trial. | Khan, S. H. Wang, S. Harrawood, A. Martinez, S. Heiderscheit, A. Chlan, L. Perkins, A. J. Tu, W. Boustani, M. Khan, B. | Trials | 2017 |
Critical care |
| Sinai Abbreviated Geriatric Evaluation: Development and Validation of a Practical Test. | Katlic, M. R. Coleman, J. Khan, K. Wozniak, S. E. Abraham, J. H. | Ann Surg | 2017 | |
| Structured interdisciplinary bedside rounds do not reduce length of hospital stay and 28-day re-admission rate among older people hospitalised with acute illness: an Australian study. | Huynh, E. Basic, D. Gonzales, R. Shanley, C. | Aust Health Rev | 2017 | |
| Cerebrospinal Fluid S100B and Alzheimer’s Disease Biomarkers in Hip Fracture Patients with Delirium. | Hov, K. R. Bolstad, N. Idland, A. V. Zetterberg, H. Blennow, K. Chaudhry, F. A. Frihagen, F. Ræder, J. Wyller, T. B. Watne, L. O. | Dementia and Geriatric Cognitive Disorders Extra | 2017 |
adult |
| Effect of various antipsychotic regimens on incidence of delirium in critically ill adults. | Hawkins, W. A. Phan, S. V. Campbell, S. L. | J Crit Care | 2017 |
Antipsychotic agents |
| 2-(18)F-fluoro-2-deoxyglucose positron emission tomography in delirium. | Haggstrom, L. R. Nelson, J. A. Wegner, E. A. Caplan, G. A. | J Cereb Blood Flow Metab | 2017 |
Aged |
| Preoperative Serum Metabolites Are Associated With Postoperative Delirium in Elderly Hip-Fracture Patients. | Guo, Y. Zhang, Y. Jia, P. Wang, W. Zhou, Q. Sun, L. Zhao, A. Zhang, X. Wang, X. Li, Y. Zhang, J. Jiang, W. | J Gerontol A Biol Sci Med Sci | 2017 |
Aged |
| Delirium and effect of circadian light in the intensive care unit: a retrospective cohort study. | Estrup, S. Kjer, C. K. W. Poulsen, L. M. Gogenur, I. Mathiesen, O. | Acta Anaesthesiol Scand | 2017 | |
| Advance Directives, Hospitalization, and Survival Among Advanced Cancer Patients with Delirium Presenting to the Emergency Department: A Prospective Study. | Elsayem, A. F. Bruera, E. Valentine, A. Warneke, C. L. Wood, G. L. Yeung, S. J. Page, V. D. Silvestre, J. Brock, P. A. Todd, K. H. | Oncologist | 2017 |
Advance directives |
| Post-operative delirium is an independent predictor of 30-day hospital readmission after spine surgery in the elderly (≥65 years old): A study of 453 consecutive elderly spine surgery patients. | Elsamadicy, A. A. Wang, T. Y. Back, A. G. Lydon, E. Reddy, G. B. Karikari, I. O. Gottfried, O. N. | Journal of Clinical Neuroscience | 2017 |
acute kidney failure |
| The Abbreviated Mental Test 4 for cognitive screening of older adults presenting to the Emergency Department. | Dyer, A. H. Briggs, R. Nabeel, S. O'Neill, D. Kennelly, S. P. | Eur J Emerg Med | 2017 | |
| A Proactive Approach to High Risk Delirium Patients Undergoing Total Joint Arthroplasty. | Duque, A. F. Post, Z. D. Orozco, F. R. Lutz, R. W. Ong, A. C. | J Arthroplasty | 2017 |
complications |
| Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients. | Culley, D. J. Flaherty, D. Fahey, M. C. Rudolph, J. L. Javedan, H. Huang, C. C. Wright, J. Bader, A. M. Hyman, B. T. Blacker, D. Crosby, G. | Anesthesiology | 2017 |
Age Factors |
| Early postoperative delirium after hemiarthroplasty in elderly patients aged over 70 years with displaced femoral neck fracture. | Choi, Y. H. Kim, D. H. Kim, T. Y. Lim, T. W. Kim, S. W. Yoo, J. H. | Clin Interv Aging | 2017 |
delirium |
| Effect of short-term exposure to ambient air particulate matter on incidence of delirium in a surgical population. | Che, L. Li, Y. Gan, C. | Sci Rep | 2017 | |
| Subsyndromal Delirium and Institutionalization Among Patients With Critical Illness. | Brummel, N. E. Boehm, L. M. Girard, T. D. Pandharipande, P. P. Jackson, J. C. Hughes, C. G. Patel, M. B. Han, J. H. Vasilevskis, E. E. Thompson, J. L. Chandrasekhar, R. Bernard, G. R. Dittus, R. S. Ely, E. W. | Am J Crit Care | 2017 | |
| Delirium in the intensive care setting: A reevaluation of the validity of the CAM-ICU and ICDSC versus the DSM-IV-TR in determining a diagnosis of delirium as part of the daily clinical routine. | Boettger, S. Nunez, D. G. Meyer, R. Richter, A. Fernandez, S. F. Rudiger, A. Schubert, M. Jenewein, J. | Palliat Support Care | 2017 |
Concurrent validity |
| Delirium in the intensive care setting and the Richmond Agitation and Sedation Scale (RASS): Drowsiness increases the risk and is subthreshold for delirium. | Boettger, S. Nunez, D. G. Meyer, R. Richter, A. Fernandez, S. F. Rudiger, A. Schubert, M. Jenewein, J. | J Psychosom Res | 2017 |
Alertness |
| Is Delirium the Cognitive Harbinger of Frailty in Older Adults? A Review about the Existing Evidence. | Bellelli, G. Moresco, R. Panina-Bordignon, P. Arosio, B. Gelfi, C. Morandi, A. Cesari, M. | Front Med | 2017 |
delirium |
| Recovery after critical illness: putting the puzzle together-a consensus of 29. | Azoulay, Elie Vincent, Jean-Louis Angus, Derek C. Arabi, Yaseen M. Brochard, Laurent Brett, Stephen J. Citerio, Giuseppe Cook, Deborah J. Curtis, Jared Randall dos Santos, Claudia C. Ely, E. Wesley Hall, Jesse Halpern, Scott D. Hart, Nicholas Hopkins, Ram | Crit Care | 2017 | |
| The efficacy of antipsychotics for prolonged delirium with renal dysfunction. | Asano, S. Kunii, Y. Hoshino, H. Osakabe, Y. Shiga, T. Itagaki, S. Miura, I. Yabe, H. | Neuropsychiatr Dis Treat | 2017 |
antipsychotic |
| Comparison of the effect of high versus low mean arterial pressure levels on clinical outcomes and complications in elderly patients during non-cardiothoracic surgery under general anesthesia: study protocol for a randomized controlled trial. | Anmin, Hu Yan, Qiu Peng, Zhang Bailong, Hu Yali, Yang Shutao, Li Rui, Zhao Zhongjun, Zhang Yaoxian, Zhang Zihao, Zheng Chen, Qiu Furong, Li Xiaolei, Gong Hu, Anmin Qiu, Yan Zhang, Peng Hu, Bailong Yang, Yali Li, Shutao Zhao, Rui | Trials | 2017 | |
| Association between baseline cognitive impairment and postoperative delirium in elderly patients undergoing surgery for adult spinal deformity. | Adogwa, O. Elsamadicy, A. A. Vuong, V. D. Fialkoff, J. Cheng, J. Karikari, I. O. Bagley, C. A. | J Neurosurg Spine | 2017 |
CAM = Confusion Assessment Method |
| Effect of the Hospital Elder Life Program on Risk of 30-Day Readmission. | Rubin, F. H. Bellon, J. Bilderback, A. Urda, K. Inouye, S. K. | Journal of the American Geriatrics Society | 2017 |
aged |
| Clinical outcomes in older surgical patients with mild cognitive impairment. | Racine, A. M. Fong, T. G. Gou, Y. Travison, T. G. Tommet, D. Erickson, K. Jones, R. N. Dickerson, B. C. Metzger, E. Marcantonio, E. R. Schmitt, E. M. Inouye, S. K. | Alzheimers Dement | 2017 |
Mild cognitive impairment |
| Prediction of Long-term Cognitive Decline Following Postoperative Delirium in Older Adults. | Devore EE, Fong TG, Marcantonio ER, Schmitt EM, Travison TG, Jones RN, Inouye SK | The journals of gerontology. Series A, Biological sciences and medical sciences | 2017 |
Aged |
| The Cognitive Reserve Model in the Development of Delirium: The Successful Aging After Elective Surgery Study. | Cizginer, S. Marcantonio, E. Vasunilashorn, S. Pascual-Leone, A. Shafi, M. Schmitt, E. M. Inouye, S. K. Jones, R. N. | J Geriatr Psychiatry Neurol | 2017 |
delirium |
| Incidence of Delirium Among Patients Having Cancer Injected With Different Opioids for the First Time. | Tanaka R, Ishikawa H, Sato T, Shino M, Matsumoto T, Mori K, Omae K, Osaka I | The American journal of hospice & palliative care | 2016 |
delirium |
| Complications after hip fracture surgery: are they preventable? | Flikweert, E. R. Wendt, K. W. Diercks, R. L. Izaks, G. J. Landsheer, D. Stevens, M. Reininga, I. H. F. | Eur J Trauma Emerg Surg | 2017 |
Complications |
| Pilot prospective study of post-surgery sleep and EEG predictors of post-operative delirium. | Evans, J. L. Nadler, J. W. Preud'homme, X. A. Fang, E. Daughtry, R. L. Chapman, J. B. Attarian, D. Wellman, S. Krystal, A. D. | Clin Neurophysiol | 2017 |
Aged |
| Development of an international undergraduate curriculum for delirium using a modified delphi process. | Copeland, C. Fisher, J. Teodorczuk, A. | Age Ageing | 2017 |
curriculum |
| Serum galectin-3 levels and delirium among postpartum intensive care unit women. | Zhu, Y. Hu, W. Zhu, M. L. Yin, T. Su, J. Wang, J. R. | Brain Behav | 2017 |
delirium |
| Characteristics of patients with an unplanned admission to an acute palliative care unit. | Mercadante, S. Adile, C. Ferrera, P. Casuccio, A. | Intern Emerg Med | 2017 |
Cancer |
| FRAIL Questionnaire Screening Tool and Short-Term Outcomes in Geriatric Fracture Patients. | Gleason, L. J. Benton, E. A. Alvarez-Nebreda, M. L. Weaver, M. J. Harris, M. B. Javedan, H. | J Am Med Dir Assoc | 2017 |
Frailty |
| Disruption of the ascending arousal system and cortical attention networks in post-stroke delirium and spatial neglect. | Boukrina, O. Barrett, A. M. | Neurosci Biobehav Rev | 2017 |
Aras |
| Incidence of delirium after cardiac surgery: protocol for the DELIRIUM-CS Canada cross-sectional cohort study. | DELIRIUM-CS Investigators, Canadian Cardiovascular Critical Care Society Investigator Group and the Canadian Critical Care Trials Group | CMAJ Open | 2017 | |
| Preoperative C-Reactive Protein as a Risk Factor for Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Surgery for Colon Carcinoma. | Xiang, Dong Xing, Hailin Tai, Huiyu Xie, Guozhu | BioMed Research International | 2017 | |
| Responding to Ten Common Delirium Misconceptions With Best Evidence: An Educational Review for Clinicians. | Oldham, M. A. Flanagan, N. M. Khan, A. Boukrina, O. Marcantonio, E. R. | J Neuropsychiatry Clin Neurosci | 2017 |
Cognitive Disorders |
| The network model of delirium. | Young JWS | Medical hypotheses | 2017 |
Default-mode network |
| Aging and Post-Intensive Care Syndrome: A Critical Need for Geriatric Psychiatry. | Wang, S. Allen, D. Kheir, Y. N. Campbell, N. Khan, B. | Am J Geriatr Psychiatry | 2017 |
Aging |
| Intensive care discharge delay is associated with increased hospital length of stay: A multicentre prospective observational study. | Tiruvoipati, R. Botha, J. Fletcher, J. Gangopadhyay, H. Majumdar, M. Vij, S. Paul, E. Pilcher, D. | PLoS One | 2017 |
Adolescent |
| How can we identify patients with delirium in the emergency department?: A review of available screening and diagnostic tools. | Tamune H, Yasugi D | The American journal of emergency medicine | 2017 |
Aged |
| Symptom profile as assessed on delirium rating scale-revised-98 of delirium in respiratory intensive care unit: A study from India. | Sharma, A. Malhotra, S. Grover, S. Jindal, S. K. | Lung India | 2017 | |
| Burst-suppression ratio underestimates absolute duration of electroencephalogram suppression compared with visual analysis of intraoperative electroencephalogram. | Muhlhofer, W. G. Zak, R. Kamal, T. Rizvi, B. Sands, L. P. Yuan, M. Zhang, X. Leung, J. M. | Br J Anaesth | 2017 | |
| Post-anaesthesia care unit delirium: incidence, risk factors and associated adverse outcomes. | Hernandez, B. A. Lindroth, H. Rowley, P. Boncyk, C. Raz, A. Gaskell, A. Garcia, P. S. Sleigh, J. Sanders, R. D. | Br J Anaesth | 2017 | |
| Validation of the 4AT questionnaire in the emergency department | Gagné, A. Voyer, P. Boucher, V. Pelletier, M. Gouin, E. Berthelot, S. Daoust, R. Laguë, A. Bédard, C. Émond, M. | Canadian Journal of Emergency Medicine | 2017 |
aged |
| Incidence, prognostic factors and impact of postoperative delirium after major vascular surgery: A meta-analysis and systematic review. | Aitken, S. J. Blyth, F. M. Naganathan, V. | Vasc Med | 2017 |
aging |
| Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium. | Yoshimura, A. Goodson, C. Johns, J. T. Towe, M. M. Irvine, E. S. Rendradjaja, N. A. Max, L. K. LaFlam, A. Ledford, E. C. Probert, J. Tieges, Z. Edwin, D. H. MacLullich, A. M. J. Hogue, C. W. Lindquist, M. A. Gurakar, A. Neufeld, K. J. Kamiya, A. | Sci Rep | 2017 | |
| Comprehensive geriatric care reduces acute perioperative delirium in elderly patients with hip fractures: A meta-analysis. | Wang, Y. Tang, J. Zhou, F. Yang, L. Wu, J. | Medicine | 2017 |
Aged |
| Effect of nocturnal sound reduction on the incidence of delirium in intensive care unit patients: An interrupted time series analysis. | van de Pol, I. van Iterson, M. Maaskant, J. | Intensive Crit Care Nurs | 2017 |
Aged |
| Poorer outcomes and greater healthcare costs for hospitalised older people with dementia and delirium: a retrospective cohort study. | Tropea J, LoGiudice D, Liew D, Gorelik A, Brand C | International journal of geriatric psychiatry | 2017 |
dementia |
| Attitudes, knowledge and practices concerning delirium: a survey among intensive care unit professionals. | Trogrlić, Zoran Ista, Erwin Ponssen, Huibert H. Schoonderbeek, Jeannette F. Schreiner, Frodo Verbrugge, Serge J. Dijkstra, Annemieke Bakker, Jan Jagt, Mathieu | Nursing in Critical Care | 2017 |
Attitude of Health Personnel |
| Can we predict a delirium after cardiac surgery? A validation study of a delirium risk checklist. | Ten Broeke, M. Koster, S. Konings, T. Hensens, A. G. van der Palen, J. | Eur J Cardiovasc Nurs | 2017 |
Delirium |
| Effects of closed-loop intravenous anesthesia guided by the Bispectral index in adult patients on emergence delirium. A randomized controlled study. | Cotoia, A. Mirabella, L. Beck, R. Matrella, P. Assenzo, V. Chazot, T. Cinnella, G. Liu, N. Dambrosio, M. | Minerva Anestesiol | 2017 | |
| Early impairment of intracranial conduction time predicts mortality in deeply sedated critically ill patients: a prospective observational pilot study. | Azabou, E. Rohaut, B. Heming, N. Magalhaes, E. Morizot-Koutlidis, R. Kandelman, S. Allary, J. Moneger, G. Polito, A. Maxime, V. Annane, D. Lofaso, F. Chretien, F. Mantz, J. Porcher, R. Sharshar, T. | Ann Intensive Care | 2017 |
Altered mental status |
| Prevalence of Delirium in a Population of Elderly Outpatients with Dementia: A Retrospective Study. | Addesi, D. Maio, R. Smirne, N. Laganà, V. Altomari, N. Puccio, G. Colao, R. Cupidi, C. Perticone, F. Bruni, A. C. | Journal of Alzheimer's Disease | 2017 |
antidepressant agent |
| Validation and Psychometric Properties of the German Version of the Delirium Motor Subtype Scale (DMSS). | Garcia Nunez, D. Boettger, S. Meyer, R. Richter, A. Schubert, M. Meagher, D. Jenewein, J. | Assessment | 2017 |
German version |
| Association of Helicobacter pylori with the Risk of Hepatic Encephalopathy. | Wijarnpreecha, K. Chesdachai, S. Thongprayoon, C. Jaruvongvanich, V. Ungprasert, P. Cheungpasitporn, W. | Dig Dis Sci | 2017 |
Helicobacter Infections/*complications |
| Determination of the feasibility of a multicomponent intervention program to prevent delirium in the Intensive Care Unit: A modified RAND Delphi study. | Wassenaar, A. van den Boogaard, M. Underpin-Icu Study, Group Schoonhoven, L. Pickkers, P. | Aust Crit Care | 2017 |
Delirium |
| Incidence, correlates and outcomes associated with falls in the intensive care unit: a retrospective cohort study. | Trumble, D. Meier, M. A. Doody, M. Wang, X. Bagshaw, S. M. | Crit Care Resusc | 2017 | |
| Impact of the Orthopaedic Nurse Practitioner role on acute hospital length of stay and cost-savings for patients with hip fracture: A retrospective cohort study. | Coventry, L. L. Pickles, S. Sin, M. Towell, A. Giles, M. Murray, K. Twigg, D. E. | J Adv Nurs | 2017 |
cost-savings |
| Prevalence and risk factors for delirium diagnosis in patients followed in general practices in Germany. | Bohlken, Jens Kostev, Karel | International Psychogeriatrics | 2017 |
delirium |
| Clinical benefits of single-incision laparoscopic surgery for postoperative delirium in elderly colon cancer patients. | Nishizawa, Y. Hata, T. Takemasa, I. Yamasaki, M. Akasaka, H. Sugimoto, K. Tamai, K. Takahashi, H. Haraguchi, N. Nishimura, J. Matsuda, C. Mizushima, T. Ikenaga, M. Yamamoto, H. Murata, K. Rakugi, H. Doki, Y. Mori, M. | Surg Endosc | 2017 |
aged |
| Evaluation of Cognitive Function Following Transcatheter Aortic Valve Replacement. | Abawi, M. de Vries, R. Stella, P. R. Agostoni, P. Boelens, D. H. M. van Jaarsveld, R. C. van Dongen, C. S. Doevendans, P. A. F. M. Emmelot-Vonk, M. H. | Heart Lung and Circulation | 2017 |
adult |
| Caring for a patient with delirium in an acute hospital: The lived experience of cardiology, elderly care, renal, and respiratory nurses. | Brooke, J. Manneh, C. | Int J Nurs Pract | 2018 |
aggression |
| Association between Delirium and Prehospitalization Medication in Poststroke Patients. | Hosoya, R. Sato, Y. Ishida, E. Shibamoto, H. Hino, S. Yokote, H. Kamata, T. | J Stroke Cerebrovasc Dis | 2018 |
Derilium |
| Acute Brain Dysfunction: Development and Validation of a Daily Prediction Model. | Marra, A. Pandharipande, P. P. Shotwell, M. S. Chandrasekhar, R. Girard, T. D. Shintani, A. K. Peelen, L. M. Moons, K. Dittus, R. S. Ely, E. W. Vasilevskis, E. E. | Chest | 2018 |
Coma |
| Delirium in the Elderly. | Hshieh, T. T. Inouye, S. K. Oh, E. S. | Psychiatr Clin North Am | 2018 |
Cognitive decline |
| Barriers to delirium assessment in the intensive care unit: A literature review. | Rowley-Conwy, G. | Intensive Crit Care Nurs | 2018 |
Critical Care Nursing/*methods |
| Exploratory and Confirmatory Factor Analyses of Delirium Symptoms in a Sample of Nursing Home Residents. | Moyo P, Huang TY, Simoni-Wastila L, Harrington D | Journal of applied gerontology : the official journal of the Southern Gerontological Society | 2016 |
confirmatory factor analysis |
| Neurosurgery in Octogenarians: A Prospective Study of Perioperative Morbidity, Mortality, and Complications in Elderly Patients. | Maldaner, N. Sarnthein, J. Bozinov, O. Regli, L. Neidert, M. C. | World Neurosurgery | 2018 |
glucocorticoid |
| Delirium in the Cardiac Intensive Care Unit. | Ibrahim, K. McCarthy, C. P. McCarthy, K. J. Brown, C. H. Needham, D. M. Januzzi, J. L., Jr. McEvoy, J. W. | J Am Heart Assoc | 2018 |
critical care |
| The Diagnostic Sensitivity of the Memorial Delirium Assessment Scale—Spanish Version | Barahona, E. Pinhao, R. Galindo, V. Noguera, A. | Journal of Pain and Symptom Management | 2018 |
adult |
| First- and second-line pharmacological treatment for delirium in general hospital setting-Retrospective analysis. | Wada, K. Morita, Y. Iwamoto, T. Mifune, Y. Nojima, S. | Asian J Psychiatr | 2018 |
Consultation liaison service |
| Increasing use of cognitive measures in the operational definition of frailty-A systematic review | Vella Azzopardi, R. Beyer, I. Vermeiren, S. Petrovic, M. Van Den Noortgate, N. Bautmans, I. Gorus, E. | Ageing Res Rev | 2018 |
Aged |
| Preoperative Hemoglobin Level is Associated with Increased Health Care Use After Elective Spinal Fusion (≥3 Levels) in Elderly Male Patients with Spine Deformity. | Elsamadicy, A. A. Adogwa, O. Ongele, M. Sergesketter, A. R. Tarnasky, A. Lubkin, D. E. T. Drysdale, N. Cheng, J. Bagley, C. A. Karikari, I. O. | World Neurosurg | 2018 |
aged |
| Comprehensive geriatric assessment for older people admitted to a surgical service. | Eamer, G. Taheri, A. Chen, S. S. Daviduck, Q. Chambers, T. Shi, X. Khadaroo, R. G. | Cochrane Database of Systematic Reviews | 2018 |
clinical assessment |
| Effects of a Medication Review on Delirium in Older Hospitalised Patients: A Comparative Retrospective Cohort Study. | van Velthuijsen, E. L. Zwakhalen, S. M. G. Pijpers, E. van de Ven, L. I. Ambergen, T. Mulder, W. J. Verhey, F. R. J. Kempen, Gijm | Drugs Aging | 2018 | |
| Effect of haloperidol on survival among critically ill adults with a high risk of delirium the REDUCE randomized clinical trial | Van Den Boogaard, M. Slooter, A. J. C. Brüggemann, R. J. M. Schoonhoven, L. Beishuizen, A. Vermeijden, J. W. Pretorius, D. De Koning, J. Simons, K. S. Dennesen, P. J. W. Van Der Voort, P. H. J. Houterman, S. Van Der Hoeven, J. G. Pickkers, P. | JAMA | 2018 |
adult |
| Individualized Acute Medical Care for Cognitively Impaired Individuals: A Call Always to Pause Before Hospitalization. | Sheckter, C. C. Bott, N. T. Milstein, A. Leff, B. | J Am Geriatr Soc | 2018 |
cognitive defect |
| Baden Prevention and Reduction of Incidence of Postoperative Delirium Trial (PRIDe): a phase IV multicenter, randomized, placebo-controlled, double-blind clinical trial of ketamine versus haloperidol for prevention of postoperative delirium. | Riegger, H. Hollinger, A. Seifert, B. Toft, K. Blum, A. Zehnder, T. Siegemund, M. | Trials | 2018 |
Dos |
| Frequency and predictors of post-stroke delirium in PRospective Observational POLIsh Study (PROPOLIS) | Pasinska, P. Kowalska, K. Klimiec, E. Szyper-Maciejowska, A. Wilk, A. Klimkowicz-Mrowiec, A. | J Neurol | 2018 |
Delirium |
| Hypertension, mitral valve disease, atrial fibrillation and low education level predict delirium and worst outcome after cardiac surgery in older adults. | Oliveira, F. R. Oliveira, V. H. Oliveira, I. M. Lima, J. W. Calderaro, D. Gualandro, D. M. Caramelli, B. | BMC Anesthesiology | 2018 |
*Cardiac surgery |
| Delirium, Frailty, and Fast-Track Surgery in Oncogeriatrics: Is There a Link? | Monacelli, F. Signori, A. Prefumo, M. Giannotti, C. Nencioni, A. Romairone, E. Scabini, S. Odetti, P. | Dementia and Geriatric Cognitive Disorders Extra | 2018 |
aged |
| Confusion Strongly Associated with Antibiotic Prescribing Due to Suspected Urinary Tract Infections in Nursing Homes. | Mayne, S. Sundvall, P. D. Gunnarsson, R. | J Am Geriatr Soc | 2018 |
urinary catheter |
| Suvorexant is associated with a low incidence of delirium in critically ill patients: a retrospective cohort study. | Masuyama, T. Sanui, M. Yoshida, N. Iizuka, Y. Ogi, K. Yagihashi, S. Nagatomo, K. Sasabuchi, Y. Lefor, A. K. | Psychogeriatrics | 2018 |
critically ill |
| Do Risk Prediction Models for Postoperative Delirium Consider Patients' Preoperative Medication Use? | Kassie, G. M. Nguyen, T. A. Kalisch Ellett, L. M. Pratt, N. L. Roughead, E. E. | Drugs Aging | 2018 | |
| Predictors and Outcomes of Cardiac Surgery-Associated Delirium. A Single Centre Retrospective Cohort Study. | Jones, D. Matalanis, G. Martensson, J. Robbins, R. Shaw, M. Seevanayagam, S. Cowie, D. Bellomo, R. | Heart Lung Circ | 2018 |
Cardiac surgery |
| Delirium in older hospitalized patients-signs and actions: a retrospective patient record review. | Johansson, Y. A. Bergh, I. Ericsson, I. Sarenmalm, E. K. | BMC Geriatr | 2018 |
*Action by healthcare professionals |
| Delirium-A Framework to Improve Acute Care for Older Persons. | Inouye, S. K. | J Am Geriatr Soc | 2018 |
Acute care for elders |
| The minimal clinically important difference of the Richmond Agitation-Sedation Scale in patients with cancer with agitated delirium. | Hui, D. Hess, K. Dibaj, S. S. Arthur, J. Dev, R. Dalal, S. Reddy, S. Bruera, E. | Cancer | 2018 |
delirium |