What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Neuroleptic strategies for terminal agitation in patients with cancer and delirium at an acute palliative care unit: a single-centre, double-blind, parallel-group, randomised trial
- Authors
- Hui, D. De La Rosa, A. Wilson, A. Nguyen, T. Wu, J. Delgado-Guay, M. Azhar, A. Arthur, J. Epner, D. Haider, A. De La Cruz, M. Heung, Y. Tanco, K. Dalal, S. Reddy, A. Williams, J. Amin, S. Armstrong, T. S. Breitbart, W. Bruera, E.
- Year
- 2020
- Journal
- Lancet Oncol
- Abstract
BACKGROUND: The role of neuroleptics for terminal agitated delirium is controversial. We assessed the effect of three neuroleptic strategies on refractory agitation in patients with cancer with terminal delirium. METHODS: In this single-centre, double-blind, parallel-group, randomised trial, patients with advanced cancer, aged at least 18 years, admitted to the palliative and supportive care unit at the University of Texas MD Anderson Cancer Center (Houston, TX, USA), with refractory agitation, despite low-dose haloperidol, were randomly assigned to receive intravenous haloperidol dose escalation at 2 mg every 4 h, neuroleptic rotation with chlorpromazine at 25 mg every 4 h, or combined haloperidol at 1 mg and chlorpromazine at 12·5 mg every 4 h, until death or discharge. Rescue doses identical to the scheduled doses were administered at inception, and then hourly as needed. Permuted block randomisation (block size six; 1:1:1) was done, stratified by baseline Richmond Agitation Sedation Scale (RASS) scores. Research staff, clinicians, patients, and caregivers were masked to group assignment. The primary outcome was change in RASS score from time 0 to 24 h. Comparisons among group were done by modified intention-to-treat analysis. This completed study is registered with ClinicalTrials.gov, NCT03021486. FINDINGS: Between July 5, 2017, and July 1, 2019, 998 patients were screened for eligibility, with 68 being enrolled and randomly assigned to treatment; 45 received the masked study interventions (escalation n=15, rotation n=16, combination n=14). RASS score decreased significantly within 30 min and remained low at 24 h in the escalation group (n=10, mean RASS score change between 0 h and 24 h -3·6 [95% CI -5·0 to -2·2]), rotation group (n=11, -3·3 [-4·4 to -2·2]), and combination group (n=10, -3·0 [-4·6 to -1·4]), with no difference among groups (p=0·71). The most common serious toxicity was hypotension (escalation n=6 [40%], rotation n=5 [31%], combination n=3 [21%]); there were no treatment-related deaths. INTERPRETATION: Our data provide preliminary evidence that the three strategies of neuroleptics might reduce agitation in patients with terminal agitation. These findings are in the context of the single-centre design, small sample size, and lack of a placebo-only group. FUNDING: National Institute of Nursing Research.
- PMID
- Keywords
Aged
Antipsychotic Agents/ therapeutic use
Delirium/ drug therapy/etiology/pathology
Double-Blind Method
Female
Follow-Up Studies
Haloperidol/ therapeutic use
Humans
Male
Middle Aged
Neoplasms/ complications/psychology/therapy
Palliative Care
Prognosis
Psychomotor Agitation/ drug therapy/etiology/pathology
- Page(s)
- 989-998
- Volume
- 21
- Issue
- 7
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Rate and risk factors for a hyperactivity delirium in patients with aneurysmal subarachnoid haemorrhage. | Sauvigny, T. Mohme, M. Grensemann, J. Duhrsen, L. Regelsberger, J. Kluge, S. Schmidt, N. O. Westphal, M. Czorlich, P. | Neurosurg Rev | 2018 |
Delirium |
| Delirium in Postoperative Patients Admitted to the Intensive Care Unit. | Romanauski, T. R. Martin, E. E. Sprung, J. Martin, D. P. Schroeder, D. R. Weingarten, T. N. | Am Surg | 2018 |
Adult |
| Degree of implementation of preventive strategies for post-ICU syndrome: Multi-centre, observational study in Spain. | Raurell-Torreda, M. Arias-Rivera, S. Marti, J. D. Frade-Mera, M. J. Zaragoza-Garcia, I. Gallart, E. Velasco-Sanz, T. R. San Jose-Arribas, A. Blazquez-Martinez, E. | Enferm Intensiva | 2018 |
Critical illness |
| Surgical delay is a risk factor of delirium in hip fracture patients with mild-moderate cognitive impairment. | Pioli, G. Bendini, C. Giusti, A. Pignedoli, P. Cappa, M. Iotti, E. Ferri, M. A. Bergonzini, E. Sabetta, E. | Aging Clin Exp Res | 2018 |
Delirium |
| Predictors of Delirium Development in Older Medical Inpatients: Readily Identifiable Factors at Admission. | O’Regan, Niamh A. Fitzgerald, James Adamis, Dimitrios Molloy, David William Meagher, David Timmons, Suzanne Montero-Odasso, Manuel | Journal of Alzheimer's Disease | 2018 | |
| Processed Electroencephalogram Monitoring and Postoperative Delirium: A Systematic Review and Meta-analysis. | MacKenzie, K. K. Britt-Spells, A. M. Sands, L. P. Leung, J. M. | Anesthesiology | 2018 | |
| The influence of oxygen delivery during cardiopulmonary bypass on the incidence of delirium in CABG patients; a retrospective study | Leenders, J. Overdevest, E. van Straten, B. Golab, H. | Perfusion | 2018 |
Cabg |
| Safety of brotizolam in hospitalized patients. | Lavon, O. Bejel, S. | European Journal of Clinical Pharmacology | 2018 |
benzodiazepine derivative |
| Early delirium after cardiac surgery: An analysis of incidence and risk factors in elderly (≥65 years) and very elderly (≥80 years) patients. | Kotfis, K. Szylińska, A. Listewnik, M. Strzelbicka, M. Brykczyński, M. Rotter, I. Żukowski, M. | Clinical Interventions in Aging | 2018 |
creatinine |
| ICU delirium - a diagnostic and therapeutic challenge in the intensive care unit. | Kotfis, K. Marra, A. Ely, E. W. | Anaesthesiol Intensive Ther | 2018 |
Cam-icu |
| Melatonin and sleep in preventing hospitalized delirium: A randomized clinical trial. | Jaiswal, S. J. McCarthy, T. J. Wineinger, N. E. Kang, D. Y. Song, J. Garcia, S. van Niekerk, C. J. Lu, C. Y. Loeks, M. Owens, R. L. | Am J Med | 2018 |
Delirium |
| Intraoperative ketamine administration to prevent delirium or postoperative cognitive dysfunction: A systematic review and meta-analysis. | Hovaguimian, F. Tschopp, C. Beck-Schimmer, B. Puhan, M. | Acta Anaesthesiol Scand | 2018 |
cognitive dysfunction |
| The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses. | Hov, K. R. Neerland, B. E. Andersen, A. M. Undseth, O. Wyller, V. B. MacLullich, A. M. J. Skovlund, E. Qvigstad, E. Wyller, T. B. | BMC Pharmacol Toxicol | 2018 |
Clonidine |
| Delirium's Arousal Subtypes and Their Relationship with 6-Month Functional Status and Cognition. | Han, J. H. Hayhurst, C. J. Chandrasekhar, R. Hughes, C. G. Vasilevskis, E. E. Wilson, J. E. Schnelle, J. F. Dittus, R. S. Ely, E. W. | Psychosomatics | 2018 |
aged |
| Intraoperative electroencephalogram suppression at lower volatile anaesthetic concentrations predicts postoperative delirium occurring in the intensive care unit. | Fritz, B. A. Maybrier, H. R. Avidan, M. S. | British Journal of Anaesthesia | 2018 |
NCT02032030 |
| Efficacy of perioperative dexmedetomidine on postoperative delirium: systematic review and meta-analysis with trial sequential analysis of randomised controlled trials. | Duan, X. Coburn, M. Rossaint, R. Sanders, R. D. Waesberghe, J. V. Kowark, A. | British Journal of Anaesthesia | 2018 |
adult |
| Long-term sequelae of acute respiratory distress syndrome caused by severe community-acquired pneumonia: Delirium-associated cognitive impairment and post-traumatic stress disorder. | Denke, C. Balzer, F. Menk, M. Szur, S. Brosinsky, G. Tafelski, S. Wernecke, K. D. Deja, M. | J Int Med Res | 2018 |
Community-acquired pneumonia |
| A Performing Arts Intervention Improves Cognitive Dysfunction in 50 Hospitalized Older Adults. | Danila, M. I. Melnick, J. A. Mudano, A. Flood, K. Booth, K. Kirklin, K. Saag, K. G. | Innov Aging | 2018 |
Alternative and complementary medicine/care/therapy |
| Nursing perspectives on the confusion assessment method: a qualitative focus group study. | Wong, E. K. Lee, J. Y. Surendran, A. S. Nair, K. Della Maestra, N. Migliarini, M. St Onge, J. A. Patterson, C. J. | Age Ageing | 2018 | |
| Detection and management of hyperactive and hypoactive delirium in older patients during hospitalization: a retrospective cohort study evaluating daily practice. | van Velthuijsen, E. L. Zwakhalen, S. M. G. Mulder, W. J. Verhey, F. R. J. Kempen, Gijm | Int J Geriatr Psychiatry | 2018 |
care as usual |
| Glucose variability during delirium in diabetic and non-diabetic intensive care unit patients: A prospective cohort study. | van Keulen, K. Knol, W. Belitser, S. V. Zaal, I. J. van der Linden, P. D. Heerdink, E. R. Egberts, T. C. G. Slooter, A. J. C. | PLoS One | 2018 | |
| Evaluating the use of dexmedetomidine for the reduction of delirium: An integrative review. | Pavone, K. J. Cacchione, P. Z. Polomano, R. C. Winner, L. Compton, P. | Heart Lung | 2018 |
Delirium |
| Delirium Monitoring in Neurocritically Ill Patients: A Systematic Review. | Patel, M. B. Bednarik, J. Lee, P. Shehabi, Y. Salluh, J. I. Slooter, A. J. Klein, K. E. Skrobik, Y. Morandi, A. Spronk, P. E. Naidech, A. M. Pun, B. T. Bozza, F. A. Marra, A. John, S. Pandharipande, P. P. Ely, E. W. | Crit Care Med | 2018 | |
| Poststroke Delirium Clinical Motor Subtypes: The PRospective Observational POLIsh Study (PROPOLIS). | Pasinska, P. Kowalska, K. Klimiec, E. Wilk, A. Szyper-Maciejowska, A. Dziedzic, T. Klimkowicz-Mrowiec, A. | J Neuropsychiatry Clin Neurosci | 2018 |
Delirium |
| A systematic review of neuroimaging in delirium: predictors, correlates and consequences. | Nitchingham A, Kumar V, Shenkin S, Ferguson KJ, Caplan GA | International journal of geriatric psychiatry | 2017 |
delirium |
| The effect of dexmedetomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis. | Ng, K. T. Shubash, C. J. Chong, J. S. | Anaesthesia | 2018 |
adult |
| A Point Prevalence Study of Delirium in Italian Nursing Homes. | Morichi, V. Fedecostante, M. Morandi, A. Di Santo, S. G. Mazzone, A. Mossello, E. Bo, M. Bianchetti, A. Rozzini, R. Zanetti, E. Musicco, M. Ferrari, A. Ferrara, N. Trabucchi, M. Cherubini, A. Bellelli, G. | Dementia and Geriatric Cognitive Disorders | 2018 |
neuroleptic agent |
| Increased Readmission Risk and Healthcare Cost for Delirium Patients without Immediate Hospitalization in the Emergency Department. | Ma, I. C. Chen, K. C. Chen, W. T. Tsai, H. C. Su, C. C. Lu, R. B. Chen, P. S. Chang, W. H. Yang, Y. K. | Clin Psychopharmacol Neurosci | 2018 |
Delirium |
| The effect of chronotherapy on delirium in critical care - a systematic review. | Luther R, McLeod A | Nursing in critical care | 2017 |
Adult intensive care |
| Intraoperative use of dexmedetomidine for the prevention of emergence agitation and postoperative delirium in thoracic surgery: a randomized-controlled trial. | Kim, J. A. Ahn, H. J. Yang, M. Lee, S. H. Jeong, H. Seong, B. G. | Canadian Journal of Anesthesia | 2019 |
adult |
| Delirium following total joint replacement surgery. | Huang, J. Sprung, J. Weingarten, T. N. | Bosn J Basic Med Sci | 2019 | |
| Delirium management: Let's get physical? A systematic review and meta-analysis. | Haley, M. N. Casey, P. Kane, R. Y. Darzins, P. Lawler, K. | Australas J Ageing | 2019 |
delirium |
| Increasing Light Exposure for the Prevention of Delirium: A Systematic Review. | Groves, R. L. | Dimensions of Critical Care Nursing | 2019 |
adult |
| Perioperative Risk Factors for Postoperative Delirium in Patients Undergoing Esophagectomy. | Fuchita, M. Khan, S. H. Perkins, A. J. Gao, S. Wang, S. Kesler, K. A. Khan, B. A. | Ann Thorac Surg | 2019 | |
| Delirium and Alzheimer's Disease: A Proposed Model for Shared Pathophysiology. | Fong, T. G. Vasunilashorn, S. M. Libermann, T. Marcantonio, E. R. Inouye, S. K. | Int J Geriatr Psychiatry | 2019 |
biomarkers |
| Diagnostic Performance and Utility of Quantitative EEG Analyses in Delirium: Confirmatory Results From a Large Retrospective Case-Control Study. | Fleischmann, R. Tränkner, S. Bathe-Peters, R. Rönnefarth, M. Schmidt, S. Schreiber, S. J. Brandt, S. A. | Clinical EEG and Neuroscience | 2019 |
electroencephalograph |
| Differences in potential biomarkers of delirium between acutely ill medical and elective cardiac surgery patients. | Egberts, A. Osse, R. J. Fekkes, D. Tulen, J. H. M. van der Cammen, T. J. M. Mattace-Raso, F. U. S. | Clin Interv Aging | 2019 |
delirium |
| Translation and validation of the tibetan confusion assessment method for the intensive care unit (CAM-ICU). | Danzeng, Q. Z. Cui, N. Wang, H. Pan, W. J. Long, Y. Deji, Y. Z. Ze, C. Ren, Z. | Chin Med J (Engl) | 2019 | |
| Intra-operative Blood Transfusion Predicts Post-Operative Delirium among Older Patients Undergoing Elective Orthopedic Surgery: a Prospective Cohort Study. | Chou, M. Y. Wang, Y. C. Peng, L. N. Liang, C. K. Chu, C. S. Liao, M. C. Lin, Y. T. Hsu, C. J. Chen, L. K. | Int J Geriatr Psychiatry | 2019 |
a |
| Vitamin D levels and risk of delirium: A mendelian randomization study in the UK Biobank | Bowman, K. Jones, L. Pilling, L. C. Delgado, J. Kuchel, G. A. Ferrucci, L. Fortinsky, R. H. Melzer, D. | Neurology | 2019 | |
| Pharmacological interventions for prevention and management of delirium in intensive care patients: A systematic overview of reviews and meta-analyses. | Barbateskovic, M. Krauss, S. R. Collet, M. O. Larsen, L. K. Jakobsen, J. C. Perner, A. Wetterslev, J. | BMJ Open | 2019 |
CRD42016046628 |
| Pre-operative biomarkers and imaging tests as predictors of post-operative delirium in non-cardiac surgical patients: a systematic review. | Ayob, F. Lam, E. Ho, G. Chung, F. El-Beheiry, H. Wong, J. | BMC Anesthesiology | 2019 |
Post-operative delirium |
| Training interventions to improve general hospital care for older people with cognitive impairment: systematic review. | Abley, C. Dickinson, C. Andrews, Z. Prato, L. Lindley, L. Robinson, L. | Br J Psychiatry | 2019 |
Dementia |
| Cognitive impairment and postoperative outcomes in patients undergoing primary total hip arthroplasty: A systematic review. | Viramontes, O. Luan Erfe, B. M. Erfe, J. M. Brovman, E. Y. Boehme, J. Bader, A. M. Urman, R. D. | J Clin Anesth | 2019 |
Anesthesia |
| Autonomic cardiovascular control in older patients with acute infection and delirium: a pilot study of orthostatic stress responses. | Neerland, B. E. Wyller, T. B. Wyller, V. B. B. | BMC Geriatr | 2019 |
Autonomic function |
| The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy - A prospective, pilot observational study. | Ehler, J. Petzold, A. Wittstock, M. Kolbaske, S. Gloger, M. Henschel, J. Heslegrave, A. Zetterberg, H. Lunn, M. P. Rommer, P. S. Grossmann, A. Sharshar, T. Richter, G. Noldge-Schomburg, G. Sauer, M. | PLoS One | 2019 | |
| A systematic review of interventions to facilitate extubation in patients difficult-to-wean due to delirium, agitation, or anxiety and a meta-analysis of the effect of dexmedetomidine. | Dupuis, S. Brindamour, D. Karzon, S. Frenette, A. J. Charbonney, E. Perreault, M. M. Bellemare, P. Burry, L. Williamson, D. R. | Can J Anaesth | 2019 | |
| Haloperidol for the management of delirium in adult intensive care unit patients: A systematic review and meta-analysis of randomized controlled trials. | Zayed, Y. Barbarawi, M. Kheiri, B. Banifadel, M. Haykal, T. Chahine, A. Rashdan, L. Aburahma, A. Bachuwa, G. Seedahmed, E. | J Crit Care | 2019 |
Critically ill patients |
| Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study. | Westphal, S. Stoppe, C. Gruenewald, M. Bein, B. Renner, J. Cremer, J. Coburn, M. Schaelte, G. Boening, A. Niemann, B. Kletzin, F. Roesner, J. Strouhal, U. Reyher, C. Laufenberg-Feldmann, R. Ferner, M. Brandes, I. F. Bauer, M. Kortgen, A. Stehr, S. N. Witt | BMC Cardiovasc Disord | 2019 |
Acute kidney injury |
| Preoperative Anxiety as a Predictor of Delirium in Cancer Patients: A Prospective Observational Cohort Study. | Wada, S. Inoguchi, H. Sadahiro, R. Matsuoka, Y. J. Uchitomi, Y. Sato, T. Shimada, K. Yoshimoto, S. Daiko, H. Shimizu, K. | World J Surg | 2019 | |
| Development of a Dynamic Multi-Protein Signature of Postoperative Delirium. | Vasunilashorn, S. M. Ngo, L. H. Chan, N. Y. Zhou, W. Dillon, S. T. Otu, H. H. Inouye, S. K. Wyrobnik, I. Kuchel, G. A. McElhaney, J. E. Xie, Z. Alsop, D. C. Jones, R. N. Libermann, T. A. Marcantonio, E. R. | J Gerontol A Biol Sci Med Sci | 2019 | |
| Improved Guideline Adherence and Reduced Brain Dysfunction After a Multicenter Multifaceted Implementation of ICU Delirium Guidelines in 3,930 Patients. | Trogrlic, Z. van der Jagt, M. Lingsma, H. Gommers, D. Ponssen, H. H. Schoonderbeek, J. F. J. Schreiner, F. Verbrugge, S. J. Duran, S. Bakker, J. Ista, E. | Crit Care Med | 2019 | |
| Trajectory of severity of postoperative delirium symptoms and its prospective association with cognitive function in patients with gastric cancer: results from a prospective observational study. | Shim, E. J. Noh, H. L. Lee, K. M. Hwang, H. Son, K. L. Jung, D. Kim, W. H. Kong, S. H. Suh, Y. S. Lee, H. J. Yang, H. K. Hahm, B. J. | Support Care Cancer | 2019 |
Anesthesia |
| Sedation Variability Increases Incidence of Delirium in Adult Medical Intensive Care Unit Patients at a Tertiary Academic Medical Center. | Ritchie, B. M. Torbic, H. DeGrado, J. R. Reardon, D. P. | Am J Ther | 2019 | |
| Current Pharmacotherapy Does Not Improve Severity of Hypoactive Delirium in Patients with Advanced Cancer: Pharmacological Audit Study of Safety and Efficacy in Real World (Phase-R). | Okuyama, T. Yoshiuchi, K. Ogawa, A. Iwase, S. Yokomichi, N. Sakashita, A. Tagami, K. Uemura, K. Nakahara, R. Akechi, T. | Oncologist | 2019 |
Antipsychotic agents |
| Quality of care in hospitalized cancer patients before and after implementation of a systematic prevention program for delirium: the DELTA exploratory trial. | Ogawa, A. Okumura, Y. Fujisawa, D. Takei, H. Sasaki, C. Hirai, K. Kanno, Y. Higa, K. Ichida, Y. Sekimoto, A. Asanuma, C. | Supportive Care in Cancer | 2019 |
benzodiazepine derivative |
| Relevance of peripheral cholinesterase activity on postoperative delirium in adult surgical patients (CESARO): A prospective observational cohort study. | Müller, A. Olbert, M. Heymann, A. Zahn, P. K. Plaschke, K. von Dossow, V. Bitzinger, D. Barth, E. Meister, M. Kranke, P. Herrmann, C. Wernecke, K. D. Spies, C. D. | European Journal of Anaesthesiology | 2019 |
NCT01964274 |
| Predicting postoperative delirium and postoperative cognitive decline with combined intraoperative electroencephalogram monitoring and cerebral near-infrared spectroscopy in patients undergoing cardiac interventions. | Momeni, M. Meyer, S. Docquier, M. A. Lemaire, G. Kahn, D. Khalifa, C. Rosal Martins, M. Van Dyck, M. Jacquet, L. M. Peeters, A. Watremez, C. | J Clin Monit Comput | 2019 |
Burst suppression |
| Early Postoperative Actigraphy Poorly Predicts Hypoactive Delirium. | Maybrier, H. R. King, C. R. Crawford, A. E. Mickle, A. M. Emmert, D. A. Wildes, T. S. Avidan, M. S. Palanca, B. J. A. | J Clin Sleep Med | 2019 |
actigraphy |
| Subsyndromal delirium is associated with poor functional outcome after ischemic stroke. | Klimiec, E. Lis, A. Pera, J. Slowik, A. Dziedzic, T. | Eur J Neurol | 2019 |
confusion |
| Pharmacological Management of Delirium in the Intensive Care Unit: A Randomized Pragmatic Clinical Trial. | Khan, B. A. Perkins, A. J. Campbell, N. L. Gao, S. Farber, M. O. Wang, S. Khan, S. H. Zarzaur, B. L. Boustani, M. A. | J Am Geriatr Soc | 2019 |
benzodiazepine |
| Use of medicines that may precipitate delirium prior to hospitalisation in older Australians with delirium: An observational study. | Kassie, G. M. Kalisch Ellett, L. M. Nguyen, T. A. Roughead, E. E. | Australas J Ageing | 2019 |
delirium |
| Comprehensive risk factor evaluation of postoperative delirium following major surgery: clinical data warehouse analysis. | Kang, S. Y. Seo, S. W. Kim, J. Y. | Neurol Sci | 2019 |
Clinical data warehouse |
| Lower risk of postoperative delirium using laparoscopic approach for major abdominal surgery. | Ito, K. Suka, Y. Nagai, M. Kawasaki, K. Yamamoto, M. Koike, D. Nomura, Y. Tanaka, N. Kawaguchi, Y. | Surg Endosc | 2019 |
Laparoscopic approach |
| Delirium is associated with frequency band specific dysconnectivity in intrinsic connectivity networks: preliminary evidence from a large retrospective pilot case-control study. | Fleischmann, R. Traenkner, S. Kraft, A. Schmidt, S. Schreiber, S. J. Brandt, S. A. | Pilot Feasibility Stud | 2019 |
Biomarker |
| Risk Factors Associated With Postoperative Delirium in Patients Undergoing Head and Neck Free Flap Reconstruction. | Densky, J. Eskander, A. Kang, S. Chan, J. Tweel, B. Sitapara, J. Ozer, E. Agrawal, A. Carrau, R. Rocco, J. Teknos, T. N. Old, M. | JAMA Otolaryngol Head Neck Surg | 2019 | |
| Deprescribing in the Pharmacologic Management of Delirium: A Randomized Trial in the Intensive Care Unit. | Campbell, N. L. Perkins, A. J. Khan, B. A. Gao, S. Farber, M. O. Khan, S. Wang, S. Boustani, M. A. | J Am Geriatr Soc | 2019 |
anticholinergic |
| Reliability of mobility measures in older medical patients with cognitive impairment. | Braun, T. Thiel, C. Schulz, R. J. Gruneberg, C. | BMC Geriatr | 2019 |
Cognitive impairment |
| Effectiveness of Melatonin for the Prevention of Intensive Care Unit Delirium. | Baumgartner, L. Lam, K. Lai, J. Barnett, M. Thompson, A. Gross, K. Morris, A. | Pharmacotherapy | 2019 |
Delirium |
| Validation of the Prediction of Delirium for Intensive Care model to predict subsyndromal delirium. | Azuma, K. Mishima, S. Shimoyama, K. Ishii, Y. Ueda, Y. Sakurai, M. Morinaga, K. Fujikawa, T. Oda, J. | Acute Med Surg | 2019 |
Critical care |
| Association Between Postoperative Delirium and Long-term Cognitive Function After Major Nonemergent Surgery. | Austin, C. A. O'Gorman, T. Stern, E. Emmett, D. Sturmer, T. Carson, S. Busby-Whitehead, J. | JAMA Surg | 2019 | |
| 'I hope you get normal again': an explorative study on how delirious octogenarian patients experience their interactions with healthcare professionals and relatives after aortic valve therapy. | Instenes, I. Fridlund, B. Amofah, H. A. Ranhoff, A. H. Eide, L. S. Norekval, T. M. | Eur J Cardiovasc Nurs | 2018 |
Delirium |
| Establishing a successful perioperative geriatric service in an Australian acute surgical unit. | Styan, L. Murphy, S. Fleury, A. McGowan, B. Wullschleger, M. | ANZ Journal of Surgery | 2018 |
aged |
| Delirium and Antipsychotic Medications at Hospital Intake: Screening to Decrease Likelihood of Aggression in Inpatient Settings Among Unknown Patients With Dementia. | Wharton, T. Paulson, D. Burcher, K. Lesch, H. | Am J Alzheimers Dis Other Demen | 2018 |
behavior |
| Preoperative assessment of frailty predicts age-related events after hepatic resection: a prospective multicenter study. | Tanaka, S. Ueno, M. Iida, H. Kaibori, M. Nomi, T. Hirokawa, F. Ikoma, H. Nakai, T. Eguchi, H. Kubo, S. | J Hepatobiliary Pancreat Sci | 2018 |
Age Factors |
| Efficacy and Tolerability of Atypical Antipsychotics in the Treatment of Delirium: A Systematic Review of the Literature. | Rivière, J. van der Mast, R. C. Vandenberghe, J. Van Den Eede, F. | Psychosomatics | 2018 |
aged |
| Outcomes of Prehospital Chemical Sedation With Ketamine Versus Haloperidol and Benzodiazepine or Physical Restraint Only. | O'Connor, L. Rebesco, M. Robinson, C. Gross, K. Castellana, A. O'Connor, M. J. Restuccia, M. | Preshosp Emerg Care | 2018 |
agitated delirium |
| Just another piece of paperwork": perceptions of clinicians on delirium screening following hip fracture repair elicited in focus groups. | Oberai, T. Killington, M. Laver, K. Crotty, M. Jaarsma, R. | Int Psychogeriatr | 2018 |
aging |
| Altered mental status predicts mortality in cardiogenic shock – results from the CardShock study. | Kataja, A. Tarvasmäki, T. Lassus, J. Køber, L. Sionis, A. Spinar, J. Parissis, J. Carubelli, V. Cardoso, J. Banaszewski, M. Marino, R. Nieminen, M. S. Mebazaa, A. Harjola, V. P. | European Heart Journal: Acute Cardiovascular Care | 2018 |
NCT01374867 |
| Nurses' and physicians' approaches to delirium management in the intensive care unit: A focus group investigation. | Collet, M. O. Thomsen, T. Egerod, I. | Aust Crit Care | 2018 |
Delirium |
| Low Plasma Cholinesterase Activity is Associated With Postoperative Delirium After Noncardiac Surgery in Elderly Patients: A Prospective Observational Study. | Zhao, B. Ni, Y. Tian, X. | Psychosomatics | 2018 |
aged |
| Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults. | Zhang, Y. Shan, G. J. Zhang, Y. X. Cao, S. J. Zhu, S. N. Li, H. J. Ma, D. Wang, D. X. | British Journal of Anaesthesia | 2018 |
ChiCTR-IPR-15006209 |
| Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery. | Xie, S. Xie, M. | Pak J Pharm Sci | 2018 | |
| Development and Validation of an Electronic Health Record-Based Machine Learning Model to Estimate Delirium Risk in Newly Hospitalized Patients Without Known Cognitive Impairment. | Wong, A. Young, A. T. Liang, A. S. Gonzales, R. Douglas, V. C. Hadley, D. | JAMA Netw Open | 2018 | |
| Sedative drugs used for mechanically ventilated patients in intensive care units: a systematic review and network meta-analysis. | Wang, H. Wang, C. Wang, Y. Tong, H. Feng, Y. Li, M. Jia, L. Yu, K. | Curr Med Res Opin | 2018 |
Sedative drugs |
| Prediction of length of hospital stay and mortality in patients with delirium: A prospective cohort analysis of 200 ICU patients. | Tian, J. Chen, X. Liu, D. | Journal of Biological Regulators and Homeostatic Agents | 2018 |
adult |
| Ramelteon is Not Associated With Improved Outcomes Among Critically Ill Delirious Patients: A Single-Center Retrospective Cohort Study. | Thom, R. Bui, M. Rosner, B. Teslyar, P. Levy-Carrick, N. Wolfe, D. Klompas, M. | Psychosomatics | 2018 |
Delirium |
| A daily multidisciplinary assessment of older adults undergoing elective colorectal cancer surgery is associated with reduced delirium and geriatric syndromes. | Tarazona-Santabalbina, F. J. Llabata-Broseta, J. Belenguer-Varea, A. Alvarez-Martinez, D. Cuesta-Peredo, D. Avellana-Zaragoza, J. A. | J Geriatr Oncol | 2018 |
Colorectal surgery |
| Preventive Effect of Suvorexant for Postoperative Delirium after Coronary Artery Bypass Grafting. | Tamura, K. Maruyama, T. Sakurai, S. | Ann Thorac Cardiovasc Surg | 2018 |
Suvorexant |
| Aproach to the risk of delirium in an orthogeriatric unit. | Sopena Bert, E. Qanneta, R. Valenti Moreno, V. San Jose Laporte, A. | Med Clin | 2018 |
Delirium |
| A systematic review of the use of music interventions to improve outcomes for patients undergoing hip or knee surgery. | Sibanda, A. Carnes, D. Visentin, D. Cleary, M. | J Adv Nurs | 2018 |
anxiety |
| Use of "Months of the Year Backwards" (MOTYB) as a Screening Tool for Delirium in Palliative Care Patients in the Acute Hospital Setting. | Ryan, S. Hayes, D. Creedon, B. | Ir Med J | 2018 | |
| Impact of psychotic symptoms on clinical outcomes in delirium. | Paik, S. H. Ahn, J. S. Min, S. Park, K. C. Kim, M. H. | PLoS ONE | 2018 |
neuroleptic agent |
| Preoperative age and prognostic nutritional index are useful factors for evaluating postoperative delirium among patients with adult spinal deformity. | Oe, S. Togawa, D. Yamato, Y. Hasegawa, T. Yoshida, G. Kobayashi, S. Yasuda, T. Banno, T. Arima, H. Mihara, Y. Ushirozako, H. Yamada, T. Matsuyama, Y. | Spine | 2018 | |
| Decreased Risk of Delirium With Use of Regional Analgesia in Geriatric Trauma Patients With Multiple Rib Fractures. | O'Connell, K. M. Quistberg, D. A. Tessler, R. Robinson, B. R. H. Cuschieri, J. Maier, R. V. Rivara, F. P. Vavilala, M. S. Bhalla, P. I. Arbabi, S. | Ann Surg | 2018 |
OBJECTIVE: The aim of this study was to examine the risk of delirium in geriatric trauma patients with rib fractures treated with systemic opioids compared with those treated with regional analgesia (RA). SUMMARY OF BACKGROUND DATA: Delirium is a modifiable complication associated with increased morbidity and mortality. RA may reduce the need for opioid medications, which are associated with delirium in older adults. METHODS: Cohort study of patients >/=65 years admitted to a regional trauma center from 2011 to 2016. Inclusion factors were >/= 3 rib fractures, blunt trauma mechanism, and admission to intensive care unit (ICU). Exclusion criteria included head AIS >/=3, spine AIS >/=3, dementia, and death within 24 hours. The primary outcome was delirium positive ICU days, defined using the CAM-ICU assessment. Delirium incident rate ratios (IRRs) and 95% confidence intervals (95% CIs) were estimated using generalized linear mixed models with Poisson distribution and robust standard errors. RESULTS: Of the 144 patients included in the study, 27 (19%) received Acute Pain Service consultation and RA and 117 (81%) received opioid-based systemic analgesia. Patients with RA had more severe chest injury than those without. The risk of delirium decreased by 24% per day per patient with use of RA (IRR 0.76, 95% CI 0.61 to 0.96). Individual opioid use, as measured in daily morphine equivalents (MEDs), was significantly reduced after initiation of RA (mean difference -7.62, 95% CI -14.4 to -0.81). CONCLUSION: Although use of RA techniques in geriatric trauma patients with multiple rib fractures was associated with higher MED, opioid use decreased after RA initiation and Acute Pain Service consultation, and the risk of delirium was lower. |
| Hypotension and a positive fluid balance are associated with delirium in patients with shock. | Nguyen, D. N. Huyghens, L. Parra, J. Schiettecatte, J. Smitz, J. Vincent, J. L. | PLoS One | 2018 | |
| End-Tidal Hypocapnia Under Anesthesia Predicts Postoperative Delirium. | Mutch, W. A. C. El-Gabalawy, R. Girling, L. Kilborn, K. Jacobsohn, E. | Front Neurol | 2018 |
*anesthetic agent |
| Risk Factors for Delirium after Spine Surgery: An Age-Matched Analysis. | Morino, T. Hino, M. Yamaoka, S. Misaki, H. Ogata, T. Imai, H. Miura, H. | Asian Spine J | 2018 |
Delirium |
| Outcomes of Patients With Delirium in Long-Term Care Facilities: A Prospective Cohort Study. | Moon, K. J. Park, H. | J Gerontol Nurs | 2018 |
Aged |
| Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery. | Miller, D. Lewis, S. R. Pritchard, M. W. Schofield-Robinson, O. J. Shelton, C. L. Alderson, P. Smith, A. F. | Cochrane Database of Systematic Reviews | 2018 |
Aged |