What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.
- Authors
- Miller, D. Lewis, S. R. Pritchard, M. W. Schofield-Robinson, O. J. Shelton, C. L. Alderson, P. Smith, A. F.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
BACKGROUND: The use of anaesthetics in the elderly surgical population (more than 60 years of age) is increasing. Postoperative delirium, an acute condition characterized by reduced awareness of the environment and a disturbance in attention, typically occurs between 24 and 72 hours after surgery and can affect up to 60% of elderly surgical patients. Postoperative cognitive dysfunction (POCD) is a new-onset of cognitive impairment which may persist for weeks or months after surgery.Traditionally, surgical anaesthesia has been maintained with inhalational agents. End-tidal concentrations require adjustment to balance the risks of accidental awareness and excessive dosing in elderly people. As an alternative, propofol-based total intravenous anaesthesia (TIVA) offers a more rapid recovery and reduces postoperative nausea and vomiting. Using TIVA with a target controlled infusion (TCI) allows plasma and effect-site concentrations to be calculated using an algorithm based on age, gender, weight and height of the patient.TIVA is a viable alternative to inhalational maintenance agents for surgical anaesthesia in elderly people. However, in terms of postoperative cognitive outcomes, the optimal technique is unknown. OBJECTIVES: To compare maintenance of general anaesthesia for elderly people undergoing non-cardiac surgery using propofol-based TIVA or inhalational anaesthesia on postoperative cognitive function, mortality, risk of hypotension, length of stay in the postanaesthesia care unit (PACU), and hospital stay. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2017, Issue 11), MEDLINE (1946 to November 2017), Embase (1974 to November 2017), PsycINFO (1887 to November 2017). We searched clinical trials registers for ongoing studies, and conducted backward and forward citation searching of relevant articles. SELECTION CRITERIA: We included randomized controlled trials (RCTs) with participants over 60 years of age scheduled for non-cardiac surgery under general anaesthesia. We planned to also include quasi-randomized trials. We compared maintenance of anaesthesia with propofol-based TIVA versus inhalational maintenance of anaesthesia. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed studies for inclusion, extracted data, assessed risk of bias, and synthesized findings. MAIN RESULTS: We included 28 RCTs with 4507 randomized participants undergoing different types of surgery (predominantly cardiovascular, laparoscopic, abdominal, orthopaedic and ophthalmic procedures). We found no quasi-randomized trials. Four studies are awaiting classification because we had insufficient information to assess eligibility.All studies compared maintenance with propofol-based TIVA versus inhalational maintenance of anaesthesia. Six studies were multi-arm and included additional TIVA groups, additional inhalational maintenance or both. Inhalational maintenance agents included sevoflurane (19 studies), isoflurane (eight studies), and desflurane (three studies), and was not specified in one study (reported as an abstract). Some studies also reported use of epidural analgesia/anaesthesia, fentanyl and remifentanil.We found insufficient reporting of randomization methods in many studies and all studies were at high risk of performance bias because it was not feasible to blind anaesthetists to study groups. Thirteen studies described blinding of outcome assessors. Three studies had a high of risk of attrition bias, and we noted differences in the use of analgesics between groups in six studies, and differences in baseline characteristics in five studies. Few studies reported clinical trials registration, which prevented assessment of risk of selective reporting bias.We found no evidence of a difference in incidences of postoperative delirium according to type of anaesthetic maintenance agents (odds ratio (OR) 0.59, 95% confidence interval (CI) 0.15 to 2.26; 321 participants; five studies; very low-certainty evidence); we noted during sensitivity analysis that using different time points in one study may influence direction of this result. Thirteen studies (3215 participants) reported POCD, and of these, six studies reported data that could not be pooled; we noted no difference in scores of POCD in four of these and in one study, data were at a time point incomparable to other studies. We excluded one large study from meta-analysis because study investigators had used non-standard anaesthetic management and this study was not methodologically comparable to other studies. We combined data for seven studies and found low-certainty evidence that TIVA may reduce POCD (OR 0.52, 95% CI 0.31 to 0.87; 869 participants).We found no evidence of a difference in mortality at 30 days (OR 1.21, 95% CI 0.33 to 4.45; 271 participants; three studies; very low-certainty evidence). Twelve studies reported intraoperative hypotension. We did not perform meta-analysis for 11 studies for this outcome. We noted visual inconsistencies in these data, which may be explained by possible variation in clinical management and medication used to manage hypotension in each study (downgraded to low-certainty evidence); one study reported data in a format that could not be combined and we noted little or no difference between groups in intraoperative hypotension for this study. Eight studies reported length of stay in the PACU, and we did not perform meta-analysis for seven studies. We noted visual inconsistencies in these data, which may be explained by possible differences in definition of time points for this outcome (downgraded to very low-certainty evidence); data were unclearly reported in one study. We found no evidence of a difference in length of hospital stay according to type of anaesthetic maintenance agent (mean difference (MD) 0 days, 95% CI -1.32 to 1.32; 175 participants; four studies; very low-certainty evidence).We used the GRADE approach to downgrade the certainty of the evidence for each outcome. Reasons for downgrading included: study limitations, because some included studies insufficiently reported randomization methods, had high attrition bias, or high risk of selective reporting bias; imprecision, because we found few studies; inconsistency, because we noted heterogeneity across studies. AUTHORS’ CONCLUSIONS: We are uncertain whether maintenance with propofol-based TIVA or with inhalational agents affect incidences of postoperative delirium, mortality, or length of hospital stay because certainty of the evidence was very low. We found low-certainty evidence that maintenance with propofol-based TIVA may reduce POCD. We were unable to perform meta-analysis for intraoperative hypotension or length of stay in the PACU because of heterogeneity between studies. We identified 11 ongoing studies from clinical trials register searches; inclusion of these studies in future review updates may provide more certainty for the review outcomes.
- PMID
- Keywords
Aged
Anesthesia, Inhalation
Anesthesia, Intravenous
Anesthetics, Inhalation
Anesthetics, Intravenous/*adverse effects
Cognition/*drug effects
Cognition Disorders/chemically induced
Delirium/chemically induced
Desflurane
Humans
Hypotension/chemically induced
Isoflurane/adverse effects/analogs & derivatives
Methyl Ethers/adverse effects
Middle Aged
Postoperative Complications/chemically induced/mortality
Propofol/*adverse effects
Randomized Controlled Trials as Topic
Sevoflurane
*Surgical Procedures, Operative
- Page(s)
- Volume
- 8
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Perioperative hyperglycaemia and neurocognitive outcome after surgery: a systematic review. | Hermanides, J. Qeva, E. Preckel, B. Bilotta, F. | Minerva Anestesiol | 2018 | |
| Low-dose Nocturnal Dexmedetomidine Prevents ICU Delirium: A Randomized, Placebo-controlled Trial. | Skrobik, Y. Duprey, M. S. Hill, N. S. Devlin, J. W. | Am J Respir Crit Care Med | 2018 |
delirium, sleep, intensive care, dexmedetomidine, randomized controlled trial |
| Low peripheral levels of insulin growth factor-1 are associated with high incidence of delirium among elderly patients: A systematic review and meta-analysis. | Li, D. J. Tseng, P. T. Stubbs, B. Chen, T. Y. Lin, P. Y. Chen, S. L. Thompson, T. Adamis, D. Chu, C. S. | Arch Gerontol Geriatr | 2018 |
Biomarker |
| Is anemia associated with cognitive impairment and delirium among older acute surgical patients? | Myint, P. K. Owen, S. McCarthy, K. Pearce, L. Moug, S. J. Stechman, M. J. Hewitt, J. Carter, B. | Geriatrics & Gerontology International | 2018 |
anemia |
| Intraoperative Sedation With Dexmedetomidine is Superior to Propofol for Elderly Patients Undergoing Hip Arthroplasty: A Prospective Randomized Controlled Study. | Mei, B. Meng, G. Xu, G. Cheng, X. Chen, S. Zhang, Y. Zhang, M. Liu, X. Gu, E. | Clin J Pain | 2018 | |
| Infrared pupillometry helps to detect and predict delirium in the post-anesthesia care unit. | Yang E, Kreuzer M, Hesse S, Davari P, Lee SC, García PS | Journal of clinical monitoring and computing | 2017 |
PLR-200 |
| Influence of Physical Restraint on Delirium of Adult Patients in ICU: A Nested Case-Control Study. | Pan, Y. Jiang, Z. Changrong, Y. Wang, L. Zhang, J. Zhou, J. Tao, M. Quan, M. Wu, Q. | J Clin Nurs | 2018 |
Delirium |
| Incidence of delirium in the Canadian emergency department and its consequences on hospital length of stay: A prospective observational multicentre cohort study. | Émond, M. Boucher, V. Carmichael, P. H. Voyer, P. Pelletier, M. Gouin, É Daoust, R. Berthelot, S. Lamontagne, M. E. Morin, M. Lemire, S. Minh Vu, T. T. Nadeau, A. Rheault, M. Juneau, L. Le Sage, N. Lee, J. | BMJ Open | 2018 |
aged |
| Impact of timing and duration of postoperative delirium: a retrospective observational study | Lee, H. Ju, J. W. Oh, S. Y. Kim, J. Jung, C. W. Ryu, H. G. | Surgery | 2018 | |
| Frequency and risk factors for subsyndromal delirium in an intensive care unit. | Yamada, C. Iwawaki, Y. Harada, K. Fukui, M. Morimoto, M. Yamanaka, R. | Intensive Crit Care Nurs | 2018 |
Delirium |
| Focusing on Inattention: The Diagnostic Accuracy of Brief Measures of Inattention for Detecting Delirium. | Marra, A. Jackson, J. C. Ely, E. W. Graves, A. J. Schnelle, J. F. Dittus, R. S. Wilson, A. Han, J. H. | J Hosp Med | 2018 | |
| Feasibility of Cognitive Training in Critically Ill Patients: A Pilot Study. | Wassenaar, A. Rood, P. Boelen, D. Schoonhoven, L. Pickkers, P. van den Boogaard, M. | Am J Crit Care | 2018 | |
| Evaluation of a sound environment intervention in an ICU: A feasibility study. | Johansson, L. Lindahl, B. Knutsson, S. Ogren, M. Persson Waye, K. Ringdal, M. | Aust Crit Care | 2018 |
Complex intervention |
| Effects of Haloperidol on Delirium in Adult Patients: A Systematic Review and Meta-analysis. | Shen, Y. Z. Peng, K. Zhang, J. Meng, X. W. Ji, F. | Med Princ Pract | 2018 | |
| The effect of the timing and dose of dexmedetomidine on postoperative delirium in elderly patients after laparoscopic major non-cardiac surgery: A double blind randomized controlled study. | Lee, C. Lee, C. H. Lee, G. Lee, J. Hwang, J. | J Clin Anesth | 2018 |
Cytokine |
| Effect of organisational factors on the variation in incidence of delirium in intensive care unit patients: A systematic review and meta-regression analysis. | Rood, P. Huisman-de Waal, G. Vermeulen, H. Schoonhoven, L. Pickkers, P. van den Boogaard, M. | Aust Crit Care | 2018 |
Critical care |
| Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU: A Single-Center Randomized Placebo-Controlled Trial. | Nishikimi, M. Numaguchi, A. Takahashi, K. Miyagawa, Y. Matsui, K. Higashi, M. Makishi, G. Matsui, S. Matsuda, N. | Crit Care Med | 2018 | |
| Diagnostic accuracy of delirium assessment methods in critical care patients | Barman, A. Pradhan, D. Bhattacharyya, P. Dey, S. Bhattacharjee, A. Tesia, S. S. Mitra, J. K. | Journal of Critical Care | 2018 |
Acute Physiology and Chronic Health Evaluation II |
| Delirium in ICU Patients Following Cardiac Surgery: An Observational Study. | Simeone, S. Pucciarelli, G. Perrone, M. Rea, T. Gargiulo, G. Guillari, A. Castellano, G. Di Tommaso, L. Niola, M. Iannelli, G. | J Clin Nurs | 2018 |
Icu |
| Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study. | Girard, T. D. Thompson, J. L. Pandharipande, P. P. Brummel, N. E. Jackson, J. C. Patel, M. B. Hughes, C. G. Chandrasekhar, R. Pun, B. T. Boehm, L. M. Elstad, M. R. Goodman, R. B. Bernard, G. R. Dittus, R. S. Ely, E. W. | Lancet Respir Med | 2018 | |
| Postoperative Complications Associated With Spine Surgery in Patients Older Than 90 Years: A Multicenter Retrospective Study. | Kobayashi, K. Imagama, S. Sato, K. Kato, F. Kanemura, T. Yoshihara, H. Sakai, Y. Shinjo, R. Hachiya, Y. Osawa, Y. Matsubara, Y. Ando, K. Nishida, Y. Ishiguro, N. | Global Spine J | 2018 |
complications |
| Do the Phenotypes of Symptom Fluctuation Differ Among Motor Subtypes in Patients With Delirium?. | Kim, S. Y. Kim, J. M. Kim, S. W. Kim, E. S. Kang, H. J. Lee, J. Y. Bae, K. Y. Shin, I. S. Yoon, J. S. | J Pain Symptom Manage | 2018 |
Delirium |
| Delirium and its consequences in the specialized palliative care unit: Validation of the Korean version of Memorial Delirium Assessment Scale. | Kang, B. Kim, Y. J. Suh, S. W. Son, K. L. Ahn, G. S. Park, H. Y. | Psycho-Oncology | 2018 |
adult |
| The Motoric Types of Delirium and Estimated Blood Loss during Perioperative Period in Orthopedic Elderly Patients. | Hong, N. Park, J. Y. | Biomed Res Int | 2018 | |
| CSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers Abeta42, t-tau and p-tau. | Henjum, K. Quist-Paulsen, E. Zetterberg, H. Blennow, K. Nilsson, L. N. G. Watne, L. O. | J Neuroinflammation | 2018 |
Alzheimer’s disease |
| CSF biomarkers in delirium: a systematic review. | Hall RJ, Watne LO, Cunningham E, Zetterberg H, Shenkin SD, Wyller TB, MacLullich AMJ | International journal of geriatric psychiatry | 2017 |
CSF biomarkers |
| Prediction of ICU Delirium: Validation of Current Delirium Predictive Models in Routine Clinical Practice. | Green, C. Bonavia, W. Toh, C. Tiruvoipati, R. | Crit Care Med | 2018 | |
| The Incidence of Recorded Delirium Episodes Before and After Dementia Diagnosis: Differences Between Dementia With Lewy Bodies and Alzheimer's Disease. | FitzGerald, J. M. Perera, G. Chang-Tave, A. Price, A. Rajkumar, A. P. Bhattarai, M. O'Brien, J. T. Ballard, C. Aarsland, D. Stewart, R. Mueller, C. | J Am Med Dir Assoc | 2018 |
Alzheimer’s disease |
| Pain and delirium in people with dementia in the acute general hospital setting. | Feast, A. R. White, N. Lord, K. Kupeli, N. Vickerstaff, V. Sampson, E. L. | Age Ageing | 2018 | |
| Environmental factors and risk of delirium in geriatric patients: an observational study. | Evensen, S. Saltvedt, I. Lydersen, S. Wyller, T. B. Taraldsen, K. Sletvold, O. | BMC Geriatr | 2018 |
Delirium |
| Validity of a screening method for delirium risk in older patients admitted to a general hospital in the Netherlands. | Ettema, R. Heim, N. Hamaker, M. Emmelot-Vonk, M. van der Mast, R. Schuurmans, M. | General Hospital Psychiatry | 2018 |
aged |
| Indwelling urinary catheters, aortic valve treatment and delirium: a prospective cohort study. | Eide, L. S. Ranhoff, A. H. Lauck, S. Fridlund, B. Haaverstad, R. Hufthammer, K. O. Kuiper, K. K. J. Nordrehaug, J. E. Norekval, T. M. | BMJ Open | 2018 |
Savr |
| Diagnostic value of NT-proCNP compared to NSE and S100B in cerebrospinal fluid and plasma of patients with sepsis-associated encephalopathy. | Ehler, J. Saller, T. Wittstock, M. Rommer, P. S. Chappell, D. Zwissler, B. Grossmann, A. Richter, G. Reuter, D. A. Noldge-Schomburg, G. Sauer, M. | Neurosci Lett | 2018 |
Biomarker |
| Exploration of Relationships Between Postoperative Pain and Subsyndromal Delirium in Older Adults. | Denny, D. L. Such, T. L. | Nurs Res | 2018 | |
| Prediction of Incident Delirium Using a Random Forest classifier. | Corradi, J. P. Thompson, S. Mather, J. F. Waszynski, C. M. Dicks, R. S. | J Med Syst | 2018 |
Decision support |
| The hip fracture surgery in elderly patients (HIPELD) study to evaluate xenon anaesthesia for the prevention of postoperative delirium: a multicentre, randomized clinical trial. | Coburn, M. Sanders, R. D. Maze, M. Nguyên-Pascal, M. L. Rex, S. Garrigues, B. Carbonell, J. A. Garcia-Perez, M. L. Stevanovic, A. Kienbaum, P. Neukirchen, M. Schaefer, M. S. Borghi, B. van Oven, H. Tognù, A. Al Tmimi, L. Eyrolle, L. Langeron, O. Capdevi | British Journal of Anaesthesia | 2018 |
C reactive protein |
| Effect of a single pre-operative 125 mg dose of methylprednisolone on postoperative delirium in hip fracture patients; a randomised, double-blind, placebo-controlled trial. | Clemmesen, C. G. Lunn, T. H. Kristensen, M. T. Palm, H. Foss, N. B. | Anaesthesia | 2018 |
delirium |
| Identifying Patterns of Delirium in Hospitalized Patients on Dexamethasone Using a Chart Abstraction Tool. | Chang, J. T. Atayee, R. S. Edmonds, K. P. | Journal of Pain and Palliative Care Pharmacotherapy | 2018 |
dexamethasone |
| Detecting delirium in elderly medical emergency patients: validation and subsequent modification of the German Nursing Delirium Screening Scale. | Brich, J. Baten, V. Wussmann, J. Heupel-Reuter, M. Perlov, E. Kloppel, S. Busch, H. J. | Intern Emerg Med | 2018 |
Delirium |
| Mobilizing older adults: A multi-site, exploratory and observational study on patients enrolled in the Hospital Elder Life Program (HELP). | Babine, R. L. Hyrkas, K. E. McKenzie, C. G. Wierman, H. R. | Geriatr Nurs | 2018 |
Older adults |
| Validation of the Stanford Proxy Test for Delirium (S-PTD) among critical and noncritical patients. | Alosaimi, F. D. Alghamdi, A. Alsuhaibani, R. Alhammad, G. Albatili, A. Albatly, L. Althomali, B. Aljamaan, F. Maldonado, J. R. | J Psychosom Res | 2018 |
Delirium |
| Impact of an Antipsychotic Discontinuation Bundle During Transitions of Care in Critically Ill Patients. | D’Angelo, R. G. Rincavage, M. Tata, A. L. Millstein, L. S. Gulati, M. S. Flurie, R. W. Gonzales, J. P. | J Intensive Care Med | 2019 |
urinary catheter |
| Living at home after emergency hospital admission: Prospective cohort study in older adults with and without cognitive spectrum disorder. | Burton, J. K. Guthrie, B. Hapca, S. M. Cvoro, V. Donnan, P. T. Reynish, E. L. | BMC Medicine | 2018 |
aged |
| The Association Between C-Reactive Protein and Postoperative Delirium Differs by Catechol-O-Methyltransferase Genotype. | Vasunilashorn, S. M. Ngo, L. H. Jones, R. N. Inouye, S. K. Hall, K. T. Gallagher, J. Dillon, S. T. Xie, Z. Libermann, T. A. Marcantonio, E. R. | American Journal of Geriatric Psychiatry | 2019 |
acute phase protein |
| Risk factors associated with acute in-hospital delirium for patients diagnosed with a hip fracture in the emergency department. | Thompson, C. Brienza, V. J. M. Sandre, A. Caine, S. Borgundvaag, B. McLeod, S. | Canadian Journal of Emergency Medicine | 2018 |
codeine |
| A Comparison of Early, Late, and No Treatment of Intensive Care Unit Delirium With Antipsychotics: A Retrospective Cohort Study. | Thom, R. P. Bui, M. P. Rosner, B. Teslyar, P. Levy-Carrick, N. C. Klompas, M. | The Primary Care Companion for CNS Disorders | 2018 |
neuroleptic agent |
| Postoperative Pain Management Strategies and Delirium After Transapical Aortic Valve Replacement: A Randomized Controlled Trial. | Strike, E. Arklina, B. Stradins, P. Cusimano, R. J. Osten, M. Horlick, E. Styra, R. Poonawala, H. Carroll, J. Djaiani, G. | Journal of Cardiothoracic and Vascular Anesthesia | 2018 |
adult |
| Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium: The STRIDE Randomized Clinical Trial. | Sieber, F. E. Neufeld, K. J. Gottschalk, A. Bigelow, G. E. Oh, E. S. Rosenberg, P. B. Mears, S. C. Stewart, K. J. Ouanes, J. P. P. Jaberi, M. Hasenboehler, E. A. Li, T. Wang, N. Y. | JAMA Surg | 2018 |
local anesthetic agent |
| Incidence of Delirium in Critically Ill Cancer Patients. | Sánchez-Hurtado, L. A. Hernández-Sánchez, N. Del Moral-Armengol, M. Guevara-García, H. García-Guillén, F. J. Herrera-Gómez, Á Ñamendys-Silva, S. A. | Pain Research & Management | 2018 |
adult |
| Dispersion in Scores on the Richmond Agitation and Sedation Scale as a Measure of Delirium in Patients with Subdural Hematomas. | Robinson, D. Thompson, S. Bauerschmidt, A. Melmed, K. Couch, C. Park, S. Agarwal, S. Roh, D. Connolly, E. S. Claassen, J. | Neurocritical Care | 2018 |
adult |
| Underdiagnosis of delirium in the elderly in acute care hospital settings: lessons not learned. | Ritter, S. R. F. Cardoso, A. F. Lins, M. M. P. Zoccoli, T. L. V. Freitas, M. P. D. Camargos, E. F. | Psychogeriatrics | 2018 |
aged |
| Risk Factors and Hospital Mortality in Surgical and Non-surgical Patients with Delirium. | Restrepo, D. Duque, M. Montoya, L. Berrouet, M. C. Rojas, M. Lopera, G. Giraldo, K. | Revista Colombiana de Psiquiatria | 2018 |
cholinergic receptor blocking agent |
| Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults. | Pun, B. T. Balas, M. C. Barnes-Daly, M. A. Thompson, J. L. Aldrich, J. M. Barr, J. Byrum, D. Carson, S. S. Devlin, J. W. Engel, H. J. Esbrook, C. L. Hargett, K. D. Harmon, L. Hielsberg, C. Jackson, J. C. Kelly, T. L. Kumar, V. Millner, L. Morse, A. Perme, | Crit Care Med | 2019 |
adult |
| Effects of Perioperative Dexmedetomidine on Postoperative Mortality and Morbidity: A Systematic Review and Meta-analysis | Peng, K. Ji, F. H. Liu, H. Y. Zhang, J. Chen, Q. C. Jiang, Y. H. | Clinical Therapeutics | 2018 |
adult |
| Relation Between Delirium and Anticholinergic Drug Burden in a Cohort of Hospitalized Older Patients: An Observational Study. | Pasina, L. Colzani, L. Cortesi, L. Tettamanti, M. Zambon, A. Nobili, A. Mazzone, A. Mazzola, P. Annoni, G. Bellelli, G. | Drugs Aging | 2018 |
adverse event |
| Neopterin and mini-mental state examination scores, two independent risk factors for postoperative delirium in elderly patients with open abdominal surgery. | Miao, S. Shen, P. Zhang, Q. Wang, H. Shen, J. Wang, G. Lv, D. | Journal of Cancer Research and Therapeutics | 2018 |
C reactive protein |
| Reliability and accuracy of delirium assessments among investigators at multiple international centres. | Maybrier, H. R. Mickle, A. M. Escallier, K. E. Lin, N. Schmitt, E. M. Upadhyayula, R. T. Wildes, T. S. Mashour, G. A. Palihnich, K. Inouye, S. K. Avidan, M. S. | BMJ Open | 2018 |
NCT01690988 |
| Does the melatonin receptor 1B gene polymorphism have a role in postoperative delirium? | Mahanna-Gabrielli, E. Miano, T. A. Augoustides, J. G. Kim, C. Bavaria, J. E. Andrew Kofke, W. | PLoS ONE | 2018 |
adult |
| Volatile anaesthetics and postoperative delirium in older surgical patients—A secondary analysis of prospective cohort studies | Kinjo, S. Lim, E. Magsaysay, M. V. Sands, L. P. Leung, J. M. | Acta Anaesthesiol Scand | 2019 |
desflurane |
| Addition of Suvorexant to Ramelteon Therapy for Improved Sleep Quality with Reduced Delirium Risk in Acute Stroke Patients. | Kawada, K. Ohta, T. Tanaka, K. Miyamura, M. Tanaka, S. | Journal of Stroke and Cerebrovascular Diseases | 2019 |
phosphorus 33 |
| Age-dependent morbidity and mortality outcomes after surgical aortic valve replacement. | Hussain, A. I. Auensen, A. Brunborg, C. Beitnes, J. O. Gullestad, L. Pettersen, K. I. | Interactive cardiovascular and thoracic surgery | 2018 |
NCT01794832 |
| Interventions for preventing intensive care unit delirium in adults. | Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T. | Cochrane Database of Systematic Reviews | 2018 |
ISRCTN83567338 |
| Mortality in people with dementia, delirium, and unspecified cognitive impairment in the general hospital: Prospective cohort study of 6,724 patients with 2 years follow-up. | Hapca, S. Guthrie, B. Cvoro, V. Bu, F. Rutherford, A. C. Reynish, E. Donnan, P. T. | Clinical Epidemiology | 2018 |
aged |
| Neurofilament Light in the Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium. | Halaas, N. B. Blennow, K. Idland, A. V. Wyller, T. B. Ræder, J. Frihagen, F. Staff, A. C. Zetterberg, H. Watne, L. O. | Dementia and Geriatric Cognitive Disorders | 2018 |
aged |
| Investigating speech and language impairments in delirium: A preliminary case-control study. | Green, S. Reivonen, S. Rutter, L. M. Nouzova, E. Duncan, N. Clarke, C. MacLullich, A. M. J. Tieges, Z. | PLoS One | 2018 |
aged |
| Elevated serum S-100β in patients with septic shock is associated with delirium. | Erikson, K. Ala-Kokko, T. I. Koskenkari, J. Liisanantti, J. H. Kamakura, R. Herzig, K. H. Syrjälä, H. | Acta Anaesthesiol Scand | 2019 |
interleukin 6 |
| A prospective, observational study of cerebrovascular autoregulation and its association with delirium following cardiac surgery. | Chan, B. Aneman, A. | Anaesthesia | 2019 |
FORESIGHT Elite |
| Dynamic cerebral autoregulation: A marker of post-operative delirium? | Caldas, J. R. Panerai, R. B. Bor-Seng-Shu, E. Ferreira, G. S. R. Camara, L. Passos, R. H. de-Lima-Oliveira, M. Galas, F. R. B. G. Almeida, J. P. Nogueira, R. C. Mian, N. Gaiotto, F. A. Robinson, T. G. Hajjar, L. A. | Clinical Neurophysiology | 2018 |
NCT02143544 |
| The Golden Angels: Effects of trained volunteers on specialling and readmission rates for people with dementia and delirium in rural hospitals. | Blair, A. Anderson, K. Bateman, C. | International Psychogeriatrics | 2018 |
hearing aid |
| The effectiveness of non-pharmacological interventions in reducing the incidence and duration of delirium in critically ill patients: a systematic review and meta-analysis. | Bannon, L. McGaughey, J. Verghis, R. Clarke, M. McAuley, D. F. Blackwood, B. | Intensive Care Medicine | 2018 |
adult |
| Blood Thiamine Level and Cognitive Function in Older Hospitalized Patients. | Pourhassan, M. Angersbach, B. Lueg, G. Klimek, C. N. Wirth, R. | J Geriatr Psychiatry Neurol | 2018 |
delirium |
| Low doses of ketamine reduce delirium but not opiate consumption in mechanically ventilated and sedated ICU patients: A randomised double-blind control trial. | Perbet, S. Verdonk, F. Godet, T. Jabaudon, M. Chartier, C. Cayot, S. Guerin, R. Morand, D. Bazin, J. E. Futier, E. Pereira, B. Constantin, J. M. | Anaesth Crit Care Pain Med | 2018 |
Consumption of opiates |
| CSF sodium at toxic levels precedes delirium in hip fracture patients. | Hassel, B. Mariussen, E. Idland, A. V. Dahl, G. T. Raeder, J. Frihagen, F. Berg, J. P. Chaudhry, F. A. Wyller, T. B. Watne, L. O. | Neurotoxicology | 2018 |
Cerebrospinal fluid |
| Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation. | Zamami, Y. Kouno, Y. Niimura, T. Chuma, M. Imai, T. Mitsui, M. Koyama, T. Kayano, M. Okada, N. Hamano, H. Goda, M. Imanishi, M. Takechi, K. Horinouchi, Y. Kondo, Y. Yanagawa, H. Kitamura, Y. Sendo, T. Ujike, Y. Ishizawa, K. | Pharmazie | 2018 | |
| Prevalence and risk factors of delirium and subsyndromal delirium in Chinese older adults. | Yam, K. K. Shea, Y. F. Chan, T. C. Chiu, K. C. Luk, J. K. Chu, L. W. Chan, F. H. | Geriatrics & Gerontology International | 2018 |
Chinese |
| Home-based Cognitive Prehabilitation in Older Surgical Patients: A Feasibility Study. | Vlisides, P. E. Das, A. R. Thompson, A. M. Kunkler, B. Zierau, M. Cantley, M. J. McKinney, A. M. Giordani, B. | J Neurosurg Anesthesiol | 2018 | |
| Meta-analysis of Prevalence and Risk Factors for Delirium After Transcatheter Aortic Valve Implantation. | Tilley, E. Psaltis, P. J. Loetscher, T. Davis, D. H. Harrison, S. L. Kim, S. Keage, H. A. D. | Am J Cardiol | 2018 | |
| Development and feasibility of a smartphone-based test for the objective detection and monitoring of attention impairments in delirium in the ICU. | Tang, E. Laverty, M. Weir, A. Wilson, E. S. Walsh, T. S. Allerhand, M. Parks, S. MacLullich, A. M. J. Tieges, Z. | J Crit Care | 2018 |
Arousal |
| Retrospective Analysis of Perioperative Variables Associated With Postoperative Delirium and Other Adverse Outcomes in Older Patients After Spine Surgery. | Susano, M. J. Scheetz, S. D. Grasfield, R. H. Cheung, D. Xu, X. Kang, J. D. Smith, T. R. Lu, Y. Groff, M. W. Chi, J. H. Crosby, G. Culley, D. J. | J Neurosurg Anesthesiol | 2018 | |
| Delirium detection by a novel bispectral electroencephalography device in general hospital. | Shinozaki, G. Chan, A. C. Sparr, N. A. Zarei, K. Gaul, L. N. Heinzman, J. T. Robles, J. Yuki, K. Chronis, T. J. Ando, T. Wong, T. Sabbagh, S. Weckmann, M. T. Lee, S. Yamada, T. Karam, M. D. Noiseux, N. O. Shinozaki, E. Cromwell, J. W. | Psychiatry Clin Neurosci | 2018 |
Aged |
| Incremental cost and length of stay associated with postprocedure delirium in transcatheter and surgical aortic valve replacement patients in the United States. | Potter, B. J. Thompson, C. Green, P. Clancy, S. | Catheterization and Cardiovascular Interventions | 2018 |
aortic |
| Effect of regional versus general anaesthesia on postoperative delirium in elderly patients undergoing surgery for hip fracture: a systematic review. | Patel, V. Champaneria, R. Dretzke, J. Yeung, J. | BMJ Open | 2018 |
general anaesthesia |
| The Role of Perioperative Statin Use in the Prevention of Delirium After Total Knee Replacement Under Spinal Anesthesia. | Oh, T. K. Park, H. Y. Shin, H. J. Jeon, Y. T. Do, S. H. Hwang, J. W. | J Arthroplasty | 2018 |
analgesics |
| Observational Study Examining the Association of Baseline Frailty and Postcardiac Surgery Delirium and Cognitive Change. | Nomura, Y. Nakano, M. Bush, B. Tian, J. Yamaguchi, A. Walston, J. Hasan, R. Zehr, K. Mandal, K. LaFlam, A. Neufeld, K. J. Kamath, V. Hogue, C. W. Brown, C. H. th | Anesth Analg | 2018 | |
| CAM-ICU may not be the optimal screening tool for early delirium screening in older emergency department patients: a prospective cohort study. | Lucke, J. A. De Gelder, J. Blomaard, L. C. Fogteloo, A. J. Alsma, J. Schuit, S. C. E. Brink, A. De Groot, B. Blauw, G. J. Mooijaart, S. P. | Eur J Emerg Med | 2018 | |
| Relation of postoperative serum S100A12 levels to delirium and cognitive dysfunction occurring after hip fracture surgery in elderly patients. | Li, Q. H. Yu, L. Yu, Z. W. Fan, X. L. Yao, W. X. Ji, C. Deng, F. Luo, X. Z. Sun, J. L. | Brain Behav | 2018 |
S100a12 |
| A scoping review to map empirical evidence regarding key domains and questions in the clinical pathway of delirium in palliative care. | Lawlor, P. G. Rutkowski, N. A. MacDonald, A. R. Ansari, M. T. Sikora, L. Momoli, F. Kanji, S. Wright, D. K. Rosenberg, E. Hosie, A. Pereira, J. L. Meagher, D. Rice, J. Scott, J. Bush, S. H. | J Pain Symptom Manage | 2018 |
analytic framework |
| Arousal changes and delirium in acute medically-ill male older patients with and without dementia: a prospective study during hospitalization. | Lagarto, L. Albuquerque, E. Loureiro, D. Vieira, F. Esteves, P. Neves, S. Teixeira-Verissimo, M. Cerejeira, J. | Aging Ment Health | 2018 |
Arousal |
| Incidence and Prevalence of Delirium Subtypes in an Adult ICU: A Systematic Review and Meta-Analysis. | Krewulak, K. D. Stelfox, H. T. Leigh, J. P. Ely, E. W. Fiest, K. M. | Crit Care Med | 2018 | |
| Association between death and loss of stage N2 sleep features among critically Ill patients with delirium. | Knauert, M. P. Gilmore, E. J. Murphy, T. E. Yaggi, H. K. Van Ness, P. H. Han, L. Hirsch, L. J. Pisani, M. A. | J Crit Care | 2018 |
Critical illness |
| Preventing Postoperative Delirium After Major Noncardiac Thoracic Surgery-A Randomized Clinical Trial. | Khan, B. A. Perkins, A. J. Campbell, N. L. Gao, S. Khan, S. H. Wang, S. Fuchita, M. Weber, D. J. Zarzaur, B. L. Boustani, M. A. Kesler, K. | J Am Geriatr Soc | 2018 |
Icu |
| Effect of nonpharmacological interventions for the prevention of delirium in the intensive care unit: A systematic review and meta-analysis. | Kang, J. Lee, M. Ko, H. Kim, S. Yun, S. Jeong, Y. Cho, Y. | J Crit Care | 2018 |
Delirium |
| Assessment of Instruments for Measurement of Delirium Severity: A Systematic Review. | Jones, R. N. Cizginer, S. Pavlech, L. Albuquerque, A. Daiello, L. A. Dharmarajan, K. Gleason, L. J. Helfand, B. Massimo, L. Oh, E. Okereke, O. I. Tabloski, P. Rabin, L. A. Yue, J. Marcantonio, E. R. Fong, T. G. Hshieh, T. T. Metzger, E. D. Erickson, K. Sc | JAMA Intern Med | 2018 | |
| Nurses' Recognition of Hospitalized Older Patients With Delirium and Cognitive Impairment Using the Delirium Observation Screening Scale: A Prospective Comparison Study. | Hasemann, W. Tolson, D. Godwin, J. Spirig, R. Frei, I. A. Kressig, R. W. | J Gerontol Nurs | 2018 | |
| Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium. | Halaas, N. B. Blennow, K. Idland, A. V. Wyller, T. B. Raeder, J. Frihagen, F. Staff, A. C. Zetterberg, H. Watne, L. O. | Dement Geriatr Cogn Disord | 2018 |
*Blood and cerebrospinal fluid biomarker |
| Delirium Subtypes and Associated Characteristics in Older Patients With Exacerbation of Chronic Conditions. | Gual, N. Inzitari, M. Carrizo, G. Calle, A. Udina, C. Yuste, A. Morandi, A. | Am J Geriatr Psychiatry | 2018 |
Delirium motor subtypes |
| Antimicrobial exposure and the risk of delirium in critically ill patients. | Grahl, J. J. Stollings, J. L. Rakhit, S. Person, A. K. Wang, L. Thompson, J. L. Pandharipande, P. P. Ely, E. W. Patel, M. B. | Crit Care | 2018 |
*Antibiotics |
| Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness. | Girard, T. D. Exline, M. C. Carson, S. S. Hough, C. L. Rock, P. Gong, M. N. Douglas, I. S. Malhotra, A. Owens, R. L. Feinstein, D. J. Khan, B. Pisani, M. A. Hyzy, R. C. Schmidt, G. A. Schweickert, W. D. Hite, R. D. Bowton, D. L. Masica, A. L. Thompson, J. | N Engl J Med | 2018 | |
| A Systematic Review and Meta-Analysis Examining the Impact of Sleep Disturbance on Postoperative Delirium. | Fadayomi, A. B. Ibala, R. Bilotta, F. Westover, M. B. Akeju, O. | Crit Care Med | 2018 | |
| Pharmacologic Treatment of Intensive Care Unit Delirium and the Impact on Duration of Delirium, Length of Intensive Care Unit Stay, Length of Hospitalization, and 28-Day Mortality. | Daniels, L. M. Nelson, S. B. Frank, R. D. Park, J. G. | Mayo Clin Proc | 2018 |