What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Predictive factors for the duration of subsyndromal delirium in the intensive care unit | Song, C. Wang, S. Liu, J. Xu, W. Yang, Y. Li, X. | J Clin Nurs | 2024 |
Humans |
| Cognitive and functional change in skilled nursing facilities: Differences by delirium and Alzheimer's disease and related dementias | Saczynski, J. S. Koethe, B. Fick, D. M. Vo, Q. T. Devlin, J. W. Marcantonio, E. R. Briesacher, B. A. | J Am Geriatr Soc | 2024 |
Alzheimer’s disease and related dementias |
| Effects of a Standardized Patient-Based Delirium Care Education Program | Roh, Y. S. Jung, M. J. Issenberg, S. B. | Res Theory Nurs Pract | 2024 |
Humans |
| Hemoglobin level, degree of mobilization, and pneumonia are associated with the development of postoperative delirium in cemented hemiarthroplasty after femoral neck fracture | Riemenschneider, J. Dobrawa, P. Sturm, R. Meier, S. L. Verboket, R. Marzi, I. Störmann, P. | Eur J Trauma Emerg Surg | 2024 |
Complications |
| Assessing Delirium in Patients With Neurological Diseases | Nisgaard, M. G. Boesen, S. V. Jensen, J. | J Neurosci Nurs | 2024 |
Delirium Intensive Care Delirium Screening Checklist Confusion Assessment Method Screening tools Hospital complications
|
| The Approach to Altered Mental Status in the Intensive Care Unit | Albin, C. S. W. Cunha, C. B. Glaser, T. P. Schachter, M. Snow, J. W. Oto, B. | The Approach to Altered Mental Status in the Intensive Care Unit | 2024 |
Altered mental status Intensive care unit Bedside assessment Delirium Review |
| Impact of inhaled sedation on delirium incidence and neurological outcome after cardiac arrest - A propensity-matched control study (Isocare) | Teiten, C. Bailly, P. Tonnelier, J. M. Bodenes, L. de Longeaux, K. L'Her, E. | Resuscitation | 2024 |
Cardiac arrest |
| Delirium care burden of intensive care nurses caring for patients undergoing open-heart surgery: A mixed-method research | Ulus, M. Durmaz Edeer, A. | Nurs Crit Care | 2024 |
caregiver burden |
| Delirium prevalence in emergency department patients: A systematic review and meta-analysis | Wang, Y. Dai, M. Chen, X. Zhang, J. | Nurs Crit Care | 2024 |
acute confusional state |
| Postoperative delirium increases follow-up mortality following hip arthroplasty in older patients with femoral neck fracture | Wu, P. Yang, Y. Yuan, A. Wang, Y. Zhang, Y. | Australas J Ageing | 2024 |
delirium |
| Analysis of risk factors for postoperative delirium in elderly patients undergoing spinal surgery | Zhang, W. P. Chang, W. X. Liu, W. Y. Li, Z. J. Mao, J. W. | Zhongguo Gu Shang | 2024 |
Humans |
| Effect of occupational therapy on the occurrence of delirium in critically ill patients: a systematic review and meta-analysis | Zhao, J. Fan, K. Zheng, S. Xie, G. Niu, X. Pang, J. Zhang, H. Wu, X. Qu, J. | Front Neurol | 2024 |
critically ill patients |
| Serum HMGB1 as a predictor for postoperative delirium in elderly patients undergoing total hip arthroplasty surgery | Zou, Y. Wu, Y. Wei, A. Nie, H. Hui, S. Liu, C. Deng, T. | Adv Clin Exp Med | 2024 |
Hmgb1 |
| The impact of adhering to a quality indicator for sedation, analgesia, and delirium management on costs, revenues, and clinical outcomes in intensive care in Germany: A retrospective observational study | Zuber, A. Rubarth, K. Förster, F. Balzer, F. Spies, C. Fürstenau, D. Kumpf, O. | PLoS One | 2024 |
Humans |
| The association between intraoperative hypotension and postoperative delirium- a retrospective cohort analysis | Zarour, S. Weiss, Y. Abu-Ganim, M. Iacubovici, L. Shaylor, R. Rosenberg, O. Matot, I. Cohen, B. | Anesthesiology | 2024 |
Hypotension Postoperative delirium Elective surgery Elderly Intraoperative Hypotension 4A’s |
| Intensive Care Unit Sleep Promotion Bundle: Impact on Sleep Quality, Delirium, and Other Patient Outcomes | Gorecki, N. M. Prasun, M. A. | Crit Care Nurse | 2024 |
Humans |
| A prospective multi-center study quantifying visual inattention in delirium using generative models of the visual processing stream | Al-Hindawi, A. Vizcaychipi, M. Demiris, Y. | Sci Rep | 2024 |
Humans |
| Correlation of preoperative inflammatory factors and emotional disorders with postoperative delirium in patients with craniocerebral trauma | Cao, P. Jia, Z. Y. Zheng, T. Mei, T. | World J Psychiatry | 2024 |
Inflammatory factors |
| Critical Assessment of the Neurological Complications during High-Risk Anesthesia Procedures | Chaudhary, F. Ahmed, Z. Agrawal, D. K. | J Surg Res (Houst) | 2024 |
Analgesics |
| Association of triglyceride-glucose index and delirium in patients with sepsis: a retrospective study | Fang, Y. Dou, A. Shen, Y. Li, T. Liu, H. Cui, Y. Xie, K. | Lipids Health Dis | 2024 |
Humans |
| The Effects of Appropriate Perioperative Exercise on Perioperative Neurocognitive Disorders: a Narrative Review | Feng, H. Zhang, Z. Lyu, W. Kong, X. Li, J. Zhou, H. Wei, P. | Mol Neurobiol | 2024 |
Humans |
| Spanish Translation and Cultural Adaptation of the Intensive Care Unit Delirium Playbook | Fuentes, A. L. Makhija, H. Fine, J. M. Alicea Reyes, P. Diaz De Leon, B. Sanchez-Azofra, A. Rodriguez-Flores, L. Weston, J. Marquine, M. J. Hu, E. Espinosa-Meza, R. Serafin Higuera, I. R. Vacas Jacques, P. Pollack, D. Novelli, F. Ely, E. W. Malhotra, A. N | ATS Sch | 2024 |
critical illness |
| Predictiveness of preoperative laboratory values for postoperative delirium | Guttenthaler, V. Fidorra, J. Wittmann, M. Menzenbach, J. | Health Sci Rep | 2024 |
older adults |
| Delirium in psychiatric settings: risk factors and assessment tools in patients with psychiatric illness: a scoping review | Huang, C. Wu, B. Chen, H. Tao, H. Wei, Z. Su, L. Wang, L. | BMC Nurs | 2024 |
Delirium |
| Differences of anticholinergic drug burden between older hospitalized patients with and without delirium: a systematic review and meta-analysis based on prospective cohort studies | Ieong, C. Chen, T. Chen, S. Gao, X. Yan, K. He, W. Hong, H. Gu, Y. Chen, X. Yuan, G. | BMC Geriatr | 2024 |
Humans |
| Nursing diagnoses as factors associated with delirium among intensive care unit patients with sepsis: A retrospective correlational study | Ji, H. Oh, E. G. Choi, M. Kim, H. Y. Kim, Y. A. Lee, K. H. | J Adv Nurs | 2024 |
Humans |
| Effectiveness of a delirium risk assessment and multidisciplinary care approach in reducing delirium incidence among surgical intensive care unit patients: A retrospective pre-post intervention study | Hsiao, W. L. Hsieh, P. Y. Hsu, L. F. Lai, Y. H. Wang, M. L. Yeh, Y. C. | J Clin Anesth | 2024 |
Critically ill |
| Incidence of Adverse Events Using Flumazenil in Patients With Iatrogenic Benzodiazepine Delirium: A Retrospective Study | Hieger, M. A. Moore, P. W. Maskell, K. F. | Am J Ther | 2024 |
*Benzodiazepines/adverse effects/antagonists & inhibitors |
| Early Opioid Use and Postoperative Delirium Following Open Abdominal Aortic Aneurysm Repair | Gutierrez, R. D. Pepic, L. Lancaster, E. M. Gasper, W. J. Hiramoto, J. S. Conte, M. S. Bongiovanni, T. Iannuzzi, J. C. | Ann Vasc Surg | 2024 |
Postoperative Delirium Open Abdominal Aortic Aneurysm repair Opioids Oral Morphine Equivalents
|
| Cardio Delirium Day: national study on the prevalence of delirium in Italian cardiology wards | Frongillo, D. Barisone, M. Gilardi, R. Usmiani, T. Falsini, G. | G Ital Cardiol (Rome) | 2024 |
Humans |
| Electroencephalographic Measures of Delirium in the Perioperative Setting: A Systematic Review | Bruzzone, M. J. Chapin, B. Walker, J. Santana, M. Wang, Y. Amini, S. Kimmet, F. Perera, E. Rubinos, C. Arias, F. Price, C. | Anesth Analg | 2024 |
Postoperative Delirium EEG Systematic Review Preoperative delirium prediction
|
| National survey on perioperative cognitive dysfunction | Aldana, E. M. Pérez de Arriba, N. Valverde, J. L. Aldecoa, C. Fábregas, N. Fernández-Candil, J. L. | Rev Esp Anestesiol Reanim (Engl Ed) | 2024 |
Perioperative cognitive dysfunction |
| Standard versus High Cardiopulmonary Bypass Flow Rate: A Randomized Controlled Subtrial Comparing Brain Injury Biomarker Release | Keiller, A. C. Axelsson, M. Bragadottir, G. Lannemyr, L. Wijk, J. Blennow, K. Zetterberg, H. Bagge, R. O. | J Cardiothorac Vasc Anesth | 2024 |
brain injury |
| Olanzapine postinjection delirium/sedation syndrome after long-acting olanzapine depot injection presenting to the emergency department: practical guidelines for diagnosis and management | Kochen, S. A. Hakkers, C. S. van Gorp, F. de Lange, D. W. Haas, L. E. M. | Emerg Med J | 2024 |
accidental |
| Postoperative use of sleep aids and delirium in older adults after major surgery: A retrospective cohort study | Lee, S. B. Park, C. M. Levin, R. Kim, D. H. | J Am Geriatr Soc | 2024 |
pharmacoepidemiology |
| A first assessment of the safe brain initiative care bundle for addressing postoperative delirium in the postanesthesia care unit | Meco, B. C. Jakobsen, K. De Robertis, E. Buhre, W. Alkış, N. Kirkegaard, P. R. Hägi-Pedersen, D. Bubser, F. Koch, S. Evered, L. A. Saunders, S. J. Caterino, M. Paolini, F. Berger-Estilita, J. Radtke, F. M. | J Clin Anesth | 2024 |
Anesthesia |
| Transplantation-Associated Altered Mentation and Encephalopathy: A New Classification for Acute Neurocognitive Changes Associated with Hematopoietic Cell Transplantation from the ASTCT Committee on Practice Guidelines | Meyers, G. Bubalo, J. Eckstrom, E. Winsnes, K. Carpenter, P. A. Artz, A. Lin, R. J. | Transplant Cell Ther | 2024 |
Humans |
| High-risk factors for delirium in severely ill patients and the application of emotional nursing combined with pain nursing | Li, H. R. Guo, Y. | World J Psychiatry | 2024 |
Critical illness |
| Association between antidepressant use and delirium in older adults: an analysis of the World Health Organization's global pharmacovigilance database | Minoc, E. M. Villain, C. Benbrika, S. Chrétien, B. Descatoire, P. Heraudeau, M. Sassier, M. Pierre, M. Martinaud, O. Dolladille, C. Lelong-Boulouard, V. | BMC Geriatr | 2024 |
Humans |
| Educational interventions aimed at improving knowledge of delirium among nursing home staff-a realist review | Molitor, V. Busse, T. S. Giehl, C. Lauer, R. Otte, I. C. Vollmar, H. C. Thürmann, P. Holle, B. Palm, R. | BMC Geriatr | 2024 |
Humans |
| Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial | Nicklas, J. Y. Bergholz, A. Däke, F. Pham, H. H. D. Rabe, M. C. Schlichting, H. Skrovanek, S. Flick, M. Kouz, K. Fischer, M. Olotu, C. Izbicki, J. R. Mann, O. Fisch, M. Schmalfeldt, B. Frosch, K. H. Renné, T. Krause, L. Zöllner, C. Saugel, B. | BJA Open | 2024 |
anaesthesia |
| The utility of the Montreal cognitive assessment (MoCA) in detecting cognitive impairment in surgical populations - A systematic review and meta-analysis | Danquah, M. O. Yan, E. Lee, J. W. Philip, K. Saripella, A. Alhamdah, Y. He, D. Englesakis, M. Chung, F. | J Clin Anesth | 2024 |
Cognitive impairment |
| Bettering Sleep Hygiene to Decrease Delirium and Improve Patient Satisfaction on an Inpatient Oncology Unit | Donovan, T. Vonnes, C. Mason, T. M. | Clin J Oncol Nurs | 2024 |
Humans |
| The effect of fascia iliaca compartment block on postoperative delirium in elder adults undergoing hip surgery: A systematic review and meta-analysis of randomized controlled trials | Duan, R. Cao, L. Zhang, H. Li, P. Wu, X. Li, J. | Int J Orthop Trauma Nurs | 2024 |
Elderly |
| Risk factors and prediction model of delirium in elderly patients after hip arthroplasty | Duan, Y. Zhang, R. | Pak J Med Sci | 2024 |
Delirium |
| Delirium prevalence and delirium literacy across Italian hospital wards: a secondary analysis of data from the World Delirium Awareness Day 2023 | Ornago, A. M. Pinardi, E. Okoye, C. Mazzola, P. Ferrara, M. C. Finazzi, A. Nydahl, P. von Haken, R. Lindroth, H. Liu, K. Morandi, A. Bellelli, G. | Eur Geriatr Med | 2024 |
Delirium |
| Association of postoperative delirium with hypotension in critically ill patients after cardiac surgery: a prospective observational study | Othman, S. M. A. Aziz, M. A. A. Al-Mushiki, G. M. A. Sriwayyapram, C. Okubai, T. Al-Muwaffaq, G. Xu, Q. Alqudaimi, M. | J Cardiothorac Surg | 2024 |
Humans |
| Cerebral autoregulation-directed optimal blood pressure management reduced the risk of delirium in patients with septic shock | Peng, Q. Liu, X. Ai, M. Huang, L. Li, L. Liu, W. Zhao, C. Hu, C. Zhang, L. | J Intensive Med | 2024 |
Cerebral regional oxygen saturation |
| From Traditional Typing to Intelligent Insights: A Narrative Review of Directions Toward Targeted Therapies in Delirium | Potter, K. M. Prendergast, N. T. Boyd, J. G. | Crit Care Med | 2024 |
Humans |
| Associations of serum lactate and lactate clearance with delirium in the early stage of ICU: a retrospective cohort study of the MIMIC-IV database | Qian, X. Sheng, Y. Jiang, Y. Xu, Y. | Front Neurol | 2024 |
Mimic-iv |
| Delirium management in perioperative geriatric services: a narrative review of non-pharmaceutical strategies | Travers, R. Gagliardi, G. Ramseyer, M. | Front Psychiatry | 2024 |
case management |
| Decreased DTI-ALPS index in delirium: a preliminary MRI study | Tu, Y. Song, R. Xiong, F. Fu, X. | Neuroradiology | 2024 |
Dti-alps |
| Association between preoperative persistent hyperglycemia and postoperative delirium in geriatric hip fracture patients | Wang, W. Zhang, Y. Yao, W. Tang, W. Li, Y. Sun, H. Ding, W. | BMC Geriatr | 2024 |
Humans |
| Impact of a Delirium Protocol on Deliriogenic Medication Use in Hospitalized Older Veterans | Weygint, A. M. LaMarr, B. Lee, S. | Sr Care Pharm | 2024 |
Humans |
| Quetiapine Twice Daily Versus Bedtime Dosing in the Treatment of ICU Delirium | Hawthorne, A. Delgado, E. Battle, A. Norton, C. | J Pharm Pract | 2024 |
Humans |
| Epigenetic signals associated with delirium replicated across four independent cohorts | Nishizawa, Y. Thompson, K. C. Yamanashi, T. Wahba, N. E. Saito, T. Marra, P. S. Nagao, T. Nishiguchi, T. Shibata, K. Yamanishi, K. Hughes, C. G. Pandharipande, P. Cho, H. Howard, M. A., 3rd Kawasaki, H. Toda, H. Kanazawa, T. Iwata, M. Shinozaki, G. | Transl Psychiatry | 2024 |
Humans |
| The Genome-wide DNA methylation changes in gastrointestinal surgery patients with and without postoperative delirium: Evidence of immune process in its pathophysiology | Nishizawa, Y. Yamanashi, T. Nishiguchi, T. Kajitani, N. Miura, A. Matsuo, R. Tanio, A. Yamamoto, M. Sakamoto, T. Fujiwara, Y. Thompson, K. Malicoat, J. Yamanishi, K. Seki, T. Kanazawa, T. Iwata, M. Shinozaki, G. | J Psychiatr Res | 2024 |
DNA methylation |
| Retinal imaging with hand-held optical coherence tomography in older people with or without postoperative delirium after hip fracture surgery: A feasibility study | Noah, A. M. Spendlove, J. Tu, Z. Proudlock, F. Constantinescu, C. S. Gottlob, I. Auer, D. P. Dineen, R. A. Moppett, I. K. | PLoS One | 2024 |
Humans |
| A world-wide study on delirium assessments and presence of protocols | Nydahl, P. Liu, K. Bellelli, G. Benbenishty, J. van den Boogaard, M. Caplan, G. Chung, C. R. Elhadi, M. Gurjar, M. Heras-La Calle, G. Hoffmann, M. Jeitziner, M. M. Krewulak, K. Mailhot, T. Morandi, A. Nawa, R. K. Oh, E. S. Collet, M. O. Paulino, M. C. Lin | Age Ageing | 2024 |
Humans |
| The interrelationship between multiple long-term conditions (MLTC) and delirium: a scoping review | Richardson, S. J. Cropp, A. D. Ellis, S. W. Gibbon, J. Sayer, A. A. Witham, M. D. | Age Ageing | 2024 |
Adult |
| Experiences of healthcare staff caring for hospitalised people with delirium: a qualitative systematic review | Siostrom, K. Snowdon, D. Sriamareswaran, R. K. Law, Y. M. Jolliffe, L. Moran, C. | Age Ageing | 2024 |
Humans |
| Nurses prioritization processes to prevent delirium in patients at risk: Findings from a Q-Methodology study | Sist, L. Pezzolati, M. Ugenti, N. V. Cedioli, S. Messina, R. Chiappinotto, S. Rucci, P. Palese, A. | Geriatr Nurs | 2024 |
Humans |
| Effect of near-infrared spectroscopy on postoperative delirium in cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis | Sun, Q. Wu, W. | Front Cardiovasc Med | 2024 |
cardiac surgery |
| Outcomes associated with postoperative cognitive dysfunction: a systematic review and meta-analysis | Suraarunsumrit, P. Srinonprasert, V. Kongmalai, T. Suratewat, S. Chaikledkaew, U. Rattanasiri, S. McKay, G. Attia, J. Thakkinstian, A. | Age Ageing | 2024 |
Aged |
| Refeeding hypophosphatemia is a common cause of delirium in critically ill patients: A retrospective study | Xu, Y. Qian, Y. Liang, P. Liu, N. Dong, D. Gu, Q. Tang, J. | Am J Med Sci | 2024 |
Consciousness |
| Electroencephalography Monitoring for Preventing Postoperative Delirium and Postoperative Cognitive Decline in Patients Undergoing Cardiothoracic Surgery: A Meta-Analysis | Xue, S. Xu, A. X. Liu, H. Zhang, Y. | Rev Cardiovasc Med | 2024 |
cardiothoracic surgery |
| Occurrence and risk factors for post-stroke delirium: A systematic review and meta-analysis | Zhang, G. B. Li, H. Y. Yu, W. J. Ying, Y. Z. Zheng, D. Zhang, X. K. Wang, Y. G. Shi, G. Z. Huang, H. W. | Asian J Psychiatr | 2024 |
Delirium |
| Description of an individualised delirium intervention in intensive care units for critically ill patients delivered by an artificial intelligence-assisted system: using the TIDieR checklist | Zhang, S. Cui, W. Wu, Y. Ji, M. | J Res Nurs | 2024 |
artificial intelligence |
| Construction and validation of a risk prediction model for postoperative delirium in patients with off‑pump coronary artery bypass grafting | Zhang, Y. Ren, M. Zhai, W. Han, J. Guo, Z. | J Thorac Dis | 2024 |
Off-pump coronary artery bypass grafting (OPCABG) |
| Predicting the Risk of Postoperative Delirium in Elderly Patients Undergoing Hip Arthroplasty: Development and Assessment of a Novel Nomogram | Zhang, Y. Xie, L. J. Wu, R. J. Zhang, C. L. Zhuang, Q. Dai, W. T. Zhou, M. X. Li, X. H. | J Invest Surg | 2024 |
Humans |
| Postoperative delirium risk in patients with hyperlipidemia: A prospective cohort study | Zhao, Y. Zhong, K. Zheng, Y. Xia, X. Lin, X. Kowark, A. Wang, X. Zhang, D. Duan, X. | J Clin Anesth | 2024 |
Cognitive decline |
| Effect of phenylephrine versus ephedrine on the incidence of postoperative delirium in olderly adults undergoing knee arthroplasty under general anesthesia: a single-center trial | Zheng, C. Wang, B. Fu, J. Peng, H. Chen, Y. Hu, X. | Sci Rep | 2024 |
Humans |
| Remimazolam for anesthesia and sedation in cardiac surgery and for cardiac patients undergoing non-cardiac surgery: a systematic-narrative hybrid review | D'Andria Ursoleo, J. Licheri, M. Barucco, G. Losiggio, R. Frau, G. Pieri, M. Monaco, F. | Minerva Anestesiol | 2024 |
Humans |
| Nurses' perceptions of patient pain, delirium, and sedation assessments in the intensive care unit: A qualitative study | Correya, A. Rawson, H. Ockerby, C. Hutchinson, A. M. | Aust Crit Care | 2024 |
Adult intensive care unit |
| Extracellular Vesicle MicroRNAs as Predictive Biomarkers in Postoperative Delirium after Spine Surgery; Preliminary Study | Cho, Y. E. Kim, J. Vorn, R. Cho, H. Baek, W. Park, H. Yun, S. Kim, H. S. Cashion, A. K. Gill, J. Koo, B. N. Lee, H. | J Gerontol A Biol Sci Med Sci | 2024 |
Exosome |
| Trace of delirium after robotic lower abdominal tumor resection at different end-tidal carbon dioxide: a RCT trial | Chen, J. Liang, S. Wei, M. Ma, Y. Bi, T. Liu, Z. Song, Y. Chen, H. Wang, Y. | BMC Anesthesiol | 2024 |
Humans |
| Adverse events related to physical restraint use in intensive care units: A review of the literature | Berger, S. Grzonka, P. Amacher, S. A. Hunziker, S. Frei, A. I. Sutter, R. | J Intensive Med | 2024 |
Adverse event |
| Managing Postoperative Delirium in Patients Receiving Head and Neck Surgery: An Educational Overview | Babu, S. Kurian Sajith, B. | Clin J Oncol Nurs | 2024 |
Humans |
| Risk Factors for Postoperative Delirium Severity After Deep Brain Stimulation Surgery in Parkinson's Disease | Astalosch, M. Mousavi, M. Ribeiro, L. M. Schneider, G. H. Stuke, H. Haufe, S. Borchers, F. Spies, C. von Hofen-Hohloch, J. Al-Fatly, B. Ebersbach, G. Franke, C. Kühn, A. A. Kübler-Weller, D. | J Parkinsons Dis | 2024 |
Parkinson’s disease |
| A Dual-Camera Eye-Tracking Platform for Rapid Real-Time Diagnosis of Acute Delirium: A Pilot Study | Al-Hindawi, A. Vizcaychipi, M. Demiris, Y. | IEEE J Transl Eng Health Med | 2024 |
Humans |
| Effectiveness of nurse-led non-pharmacological interventions on outcomes of delirium in adults: A meta-analysis of randomized controlled trials | Wang, J. Lu, Y. Chen, X. Wu, Y. | Worldviews Evid Based Nurs | 2024 |
adult health |
| Association of blood glucose change with postoperative delirium after coronary artery bypass grafting in patients with diabetes mellitus: a study of the MIMIC-IV database | Wang, F. Mei, X. | Front Endocrinol (Lausanne) | 2024 |
Humans |
| The genetic relationship between hypotension and delirium: a Mendelian randomization study | Wang, C. Wu, J. Lin, Y. Liu, Z. Liufu, N. Cao, M. | Front Neurol | 2024 |
Mendelian randomization |
| Comparison of Propofol-Based Total Intravenous Anesthesia versus Volatile Anesthesia with Sevoflurane for Postoperative Delirium in Adult Coronary Artery Bypass Grafting Surgery: A Prospective Randomized Single-Blinded Study | Varsha, A. V. Unnikrishnan, K. P. Saravana Babu, M. S. Raman, S. P. Koshy, T. | J Cardiothorac Vasc Anesth | 2024 |
cardiopulmonary bypass |
| Diagnostics and treatment of impulse control disorders, psychosis and delirium: systemic review-based recommendations - guideline "Parkinson's disease" of the German Society of Neurology | Witt, K. Levin, J. van Eimeren, T. Hasan, A. Ebersbach, G. | J Neurol | 2024 |
Delirium |
| Potential mechanism of Taohong Siwu Decoction in preventing and treating postoperative delirium in intertrochanteric fracture patients based on retrospective analysis and network pharmacology | Ding, Z. Yu, Z. Sun, Z. Liu, X. Chen, R. | J Orthop Surg Res | 2024 |
Humans |
| Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery: The ENGAGES-Canada Randomized Clinical Trial | Deschamps, A. Ben Abdallah, A. Jacobsohn, E. Saha, T. Djaiani, G. El-Gabalawy, R. Overbeek, C. Palermo, J. Courbe, A. Cloutier, I. Tanzola, R. Kronzer, A. Fritz, B. A. Schmitt, E. M. Inouye, S. K. Avidan, M. S. | Jama | 2024 |
Postoperative Delirium Anesthesia EEG-guided anesthesia Intraoperative EEG waveform suppression Older Adults |
| Association Between Pupil Light Reflex and Delirium in Adults With Traumatic Brain Injury: Preliminary Findings | Lapierre, A. Proulx, A. Gélinas, C. Dollé, S. Alexander, S. Williamson, D. Bernard, F. Arbour, C. | J Neurosci Nurs | 2024 |
Delirium ICU Delirium Traumatic Brain Injury Pupillary light reflex Postextubation delirium
|
| Prevalence and risk factors of postoperative delirium in tumor patients after free flap reconstruction: A systematic review and meta-analysis of case-control studies | Li, Y. Li, Z. Lv, Q. Gu, Y. Qi, Y. Li, J. Liu, Y. Ma, G. | Surgery | 2024 |
Postoperative Delirium Flap transplantation surgery Risk Factors Proactive prevention measures Systematic Review |
| Risk factors and risk stratification approaches for delirium screening: A Geriatric Emergency Department Guidelines 2.0 systematic review | Seidenfeld, J. Lee, S. Ragsdale, L. Nickel, C. H. Liu, S. W. Kennedy, M. | Acad Emerg Med | 2024 |
Geriatrics Delirium Emergency Department delirium screening Risk factors Delirium risk scores Systematic review |
| Examining the impact of permissibility hypercapnia on postoperative delirium among elderly patients undergoing thoracoscopic-laparoscopic esophagectomy: A single-center investigative study | Song, J. Shao, Y. M. Zhang, G. H. Fan, B. Q. Tao, W. H. Liu, X. F. Huang, X. C. Hu, X. W. | Shock | 2024 |
Postoperative delirium Permissive hypercapnia ventilation thoracic surgery intraoperative respiration |
| Association between modified frailty index and postoperative delirium in patients after cardiac surgery: A cohort study of 2080 older adults | Cheng, H. Ling, Y. Li, Q. Li, X. Tang, Y. Guo, J. Li, J. Wang, Z. Ming, W. K. Lyu, J. | CNS Neurosci Ther | 2024 |
Humans |
| Role of Intraoperative Electroencephalography in Predicting Postoperative Delirium in Patients Undergoing Cardiovascular Surgeries | Al-Qudah, A. M. Sivaguru, S. Anetakis, K. Crammond, D. J. Balzer, J. R. Thirumala, P. D. Subramaniam, K. Sadhasivam, S. Shandal, V. | Clin Neurophysiol | 2024 |
Cardiopulmonary bypass |
| Differences in metalloproteinases and their tissue inhibitors in the cerebrospinal fluid are associated with delirium | Aksnes, M. Schibstad, M. H. Chaudhry, F. A. Neerland, B. E. Caplan, G. Saltvedt, I. Eldholm, R. S. Myrstad, M. Edwin, T. H. Persson, K. Idland, A. V. Pollmann, C. T. Olsen, R. B. Wyller, T. B. Zetterberg, H. Cunningham, E. Watne, L. O. | Commun Med (Lond) | 2024 |
Alzheimer’s disease, Diagnostic markers, Dementia |
| A retrospective cohort study comparing outcomes following hip fractures in Australian indigenous patients with non-Australian indigenous patients | Cheok, T. Bastick, K. George, D. Chan, T. S. Jaitly, A. Jayasekera, N. Bray, L. Poonnoose, P. M. Williams, K. | ANZ J Surg | 2024 |
hip fracture |
| Comparing BIS Monitoring vs. Clinical Assessment for Deep Sedation in the ICU: Effects on Delirium Reduction and Sedative Drug Doses - A randomized trial | Huespe, I. Giunta, D. Acosta, K. Avila, D. Prado, E. Sanghavi, D. Carboni Bisso, I. Giannasi, S. Carini, F. C. | Chest | 2024 |
Bispectral Index,electroencephalogram-based sedation |
| Pharmacologic Management of End-of-Life Delirium: Translating Evidence into Practice | Hui, D. Cheng, S. Y. Paiva, C. E. | Cancers (Basel) | 2024 |
antipsychotic agents |
| Boarding Duration in the Emergency Department and Inpatient Delirium and Severe Agitation | Joseph, J. W. Elhadad, N. Mattison, M. L. P. Nentwich, L. M. Levine, S. A. Marcantonio, E. R. Kennedy, M. | JAMA Netw Open | 2024 |
Humans |
| Boarding Duration in the Emergency Department and Inpatient Delirium and Severe Agitation | Joseph, J. W. Elhadad, N. Mattison, M. L. P. Nentwich, L. M. Levine, S. A. Marcantonio, E. R. Kennedy, M. | JAMA Netw Open | 2024 |
Humans |
| Perioperative Blood Transfusion and Delirium after Total Knee or Hip Arthroplasty: Retrospective Analysis | Kim, S. Oh, T. K. Song, I. A. | J Pers Med | 2024 |
blood trans fusion |