What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Visualizing how to use antipsychotics for agitated delirium in the last days of life
- Authors
- Imai, K. Morita, T. Mori, M. Kikuchi, D. Yokomichi, N. Miwa, S. Okamoto, S. I. Yamauchi, T. Naito, A. S. D. Matsuda, Y. Maeda, I. Sugano, K. Inanga, M. Inoue, S. Satomi, E.
- Year
- 2023
- Journal
- J Pain Symptom Manage
- Abstract
CONTEXT: How physicians use antipsychotics for agitated delirium in the last days of life varies markedly, which could hamper the quality of care. OBJECTIVES: To examine adherence to an algorithm-based treatment for terminal agitated delirium, and explore its effectiveness and safety. METHODS: A single-center, prospective, observational study was conducted in a 27-bed palliative care unit in Japan. All adult cancer patients who developed agitated delirium with a modified Richmond Agitation-Sedation Scale (RASS) of +1 or more were included; the palliative care specialists determined that the etiology was irreversible, the estimated survival was 3 weeks or less, and the Eastern Cooperative Oncology Group (ECOG) performance status was 3 or 4. Patients were treated with an algorithm to visualize how to use antipsychotics, with the treatment goal defined as no agitation (RASS≤0) or acceptable agitation for patients and families. We provided all patients non-pharmacological management to alleviate the symptoms of delirium and administered antipsychotic medications when the non-pharmacological approach was insufficient. We measured the adherence rate, RASS, Nursing Delirium Screening Scale items 2, 3, 4 (Nu-DESC), and Agitation Distress Scale item 2 (ADS) on Days 0, 1, 3, 7, 14, 21, and 24 hours before death. RESULTS: A total of 164 patients were enrolled. Adherence rates were 99, 94, and 89%, and treatment goals were achieved in 66, 83, and 93% on Days 1, 3, and 7, respectively. The mean RASS decreased from +1.41 to -0.84 on Day 3; Nu-DESC decreased from 4.19 to 1.83, and ADS decreased from 1.54 to 0.38. There were 7 severe adverse events (Common Terminology Criteria for Adverse Events (CTCAE) of 3), including aspiration (n=3), apnea (n=2), tremor (n=1), and muscle rigidity (n=1) on Day 3. CONCLUSION: The algorithm-based treatment could be feasible, effective, and safe. Visualizing how palliative care specialists provide pharmacological management could be beneficial for non-specialist clinicians, and clinical, educational, and research implications warrant further empirical testing.
- PMID
PMID: 36682673
- Keywords
antipsychotics
chlorpromazine
haloperidol
levomepromazine
terminal agitated delirium
treatment algorithm
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Predicting postoperative delirium and postoperative cognitive decline with combined intraoperative electroencephalogram monitoring and cerebral near-infrared spectroscopy in patients undergoing cardiac interventions. | Momeni, M. Meyer, S. Docquier, M. A. Lemaire, G. Kahn, D. Khalifa, C. Rosal Martins, M. Van Dyck, M. Jacquet, L. M. Peeters, A. Watremez, C. | J Clin Monit Comput | 2019 |
Burst suppression |
| Early Postoperative Actigraphy Poorly Predicts Hypoactive Delirium. | Maybrier, H. R. King, C. R. Crawford, A. E. Mickle, A. M. Emmert, D. A. Wildes, T. S. Avidan, M. S. Palanca, B. J. A. | J Clin Sleep Med | 2019 |
actigraphy |
| Subsyndromal delirium is associated with poor functional outcome after ischemic stroke. | Klimiec, E. Lis, A. Pera, J. Slowik, A. Dziedzic, T. | Eur J Neurol | 2019 |
confusion |
| Pharmacological Management of Delirium in the Intensive Care Unit: A Randomized Pragmatic Clinical Trial. | Khan, B. A. Perkins, A. J. Campbell, N. L. Gao, S. Farber, M. O. Wang, S. Khan, S. H. Zarzaur, B. L. Boustani, M. A. | J Am Geriatr Soc | 2019 |
benzodiazepine |
| Use of medicines that may precipitate delirium prior to hospitalisation in older Australians with delirium: An observational study. | Kassie, G. M. Kalisch Ellett, L. M. Nguyen, T. A. Roughead, E. E. | Australas J Ageing | 2019 |
delirium |
| Comprehensive risk factor evaluation of postoperative delirium following major surgery: clinical data warehouse analysis. | Kang, S. Y. Seo, S. W. Kim, J. Y. | Neurol Sci | 2019 |
Clinical data warehouse |
| Lower risk of postoperative delirium using laparoscopic approach for major abdominal surgery. | Ito, K. Suka, Y. Nagai, M. Kawasaki, K. Yamamoto, M. Koike, D. Nomura, Y. Tanaka, N. Kawaguchi, Y. | Surg Endosc | 2019 |
Laparoscopic approach |
| Delirium is associated with frequency band specific dysconnectivity in intrinsic connectivity networks: preliminary evidence from a large retrospective pilot case-control study. | Fleischmann, R. Traenkner, S. Kraft, A. Schmidt, S. Schreiber, S. J. Brandt, S. A. | Pilot Feasibility Stud | 2019 |
Biomarker |
| Risk Factors Associated With Postoperative Delirium in Patients Undergoing Head and Neck Free Flap Reconstruction. | Densky, J. Eskander, A. Kang, S. Chan, J. Tweel, B. Sitapara, J. Ozer, E. Agrawal, A. Carrau, R. Rocco, J. Teknos, T. N. Old, M. | JAMA Otolaryngol Head Neck Surg | 2019 | |
| Deprescribing in the Pharmacologic Management of Delirium: A Randomized Trial in the Intensive Care Unit. | Campbell, N. L. Perkins, A. J. Khan, B. A. Gao, S. Farber, M. O. Khan, S. Wang, S. Boustani, M. A. | J Am Geriatr Soc | 2019 |
anticholinergic |
| Reliability of mobility measures in older medical patients with cognitive impairment. | Braun, T. Thiel, C. Schulz, R. J. Gruneberg, C. | BMC Geriatr | 2019 |
Cognitive impairment |
| Effectiveness of Melatonin for the Prevention of Intensive Care Unit Delirium. | Baumgartner, L. Lam, K. Lai, J. Barnett, M. Thompson, A. Gross, K. Morris, A. | Pharmacotherapy | 2019 |
Delirium |
| Validation of the Prediction of Delirium for Intensive Care model to predict subsyndromal delirium. | Azuma, K. Mishima, S. Shimoyama, K. Ishii, Y. Ueda, Y. Sakurai, M. Morinaga, K. Fujikawa, T. Oda, J. | Acute Med Surg | 2019 |
Critical care |
| Association Between Postoperative Delirium and Long-term Cognitive Function After Major Nonemergent Surgery. | Austin, C. A. O'Gorman, T. Stern, E. Emmett, D. Sturmer, T. Carson, S. Busby-Whitehead, J. | JAMA Surg | 2019 | |
| 'I hope you get normal again': an explorative study on how delirious octogenarian patients experience their interactions with healthcare professionals and relatives after aortic valve therapy. | Instenes, I. Fridlund, B. Amofah, H. A. Ranhoff, A. H. Eide, L. S. Norekval, T. M. | Eur J Cardiovasc Nurs | 2018 |
Delirium |
| Establishing a successful perioperative geriatric service in an Australian acute surgical unit. | Styan, L. Murphy, S. Fleury, A. McGowan, B. Wullschleger, M. | ANZ Journal of Surgery | 2018 |
aged |
| Delirium and Antipsychotic Medications at Hospital Intake: Screening to Decrease Likelihood of Aggression in Inpatient Settings Among Unknown Patients With Dementia. | Wharton, T. Paulson, D. Burcher, K. Lesch, H. | Am J Alzheimers Dis Other Demen | 2018 |
behavior |
| Preoperative assessment of frailty predicts age-related events after hepatic resection: a prospective multicenter study. | Tanaka, S. Ueno, M. Iida, H. Kaibori, M. Nomi, T. Hirokawa, F. Ikoma, H. Nakai, T. Eguchi, H. Kubo, S. | J Hepatobiliary Pancreat Sci | 2018 |
Age Factors |
| Efficacy and Tolerability of Atypical Antipsychotics in the Treatment of Delirium: A Systematic Review of the Literature. | Rivière, J. van der Mast, R. C. Vandenberghe, J. Van Den Eede, F. | Psychosomatics | 2018 |
aged |
| Outcomes of Prehospital Chemical Sedation With Ketamine Versus Haloperidol and Benzodiazepine or Physical Restraint Only. | O'Connor, L. Rebesco, M. Robinson, C. Gross, K. Castellana, A. O'Connor, M. J. Restuccia, M. | Preshosp Emerg Care | 2018 |
agitated delirium |
| Just another piece of paperwork": perceptions of clinicians on delirium screening following hip fracture repair elicited in focus groups. | Oberai, T. Killington, M. Laver, K. Crotty, M. Jaarsma, R. | Int Psychogeriatr | 2018 |
aging |
| Altered mental status predicts mortality in cardiogenic shock – results from the CardShock study. | Kataja, A. Tarvasmäki, T. Lassus, J. Køber, L. Sionis, A. Spinar, J. Parissis, J. Carubelli, V. Cardoso, J. Banaszewski, M. Marino, R. Nieminen, M. S. Mebazaa, A. Harjola, V. P. | European Heart Journal: Acute Cardiovascular Care | 2018 |
NCT01374867 |
| Nurses' and physicians' approaches to delirium management in the intensive care unit: A focus group investigation. | Collet, M. O. Thomsen, T. Egerod, I. | Aust Crit Care | 2018 |
Delirium |
| Low Plasma Cholinesterase Activity is Associated With Postoperative Delirium After Noncardiac Surgery in Elderly Patients: A Prospective Observational Study. | Zhao, B. Ni, Y. Tian, X. | Psychosomatics | 2018 |
aged |
| Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults. | Zhang, Y. Shan, G. J. Zhang, Y. X. Cao, S. J. Zhu, S. N. Li, H. J. Ma, D. Wang, D. X. | British Journal of Anaesthesia | 2018 |
ChiCTR-IPR-15006209 |
| Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery. | Xie, S. Xie, M. | Pak J Pharm Sci | 2018 | |
| Development and Validation of an Electronic Health Record-Based Machine Learning Model to Estimate Delirium Risk in Newly Hospitalized Patients Without Known Cognitive Impairment. | Wong, A. Young, A. T. Liang, A. S. Gonzales, R. Douglas, V. C. Hadley, D. | JAMA Netw Open | 2018 | |
| Sedative drugs used for mechanically ventilated patients in intensive care units: a systematic review and network meta-analysis. | Wang, H. Wang, C. Wang, Y. Tong, H. Feng, Y. Li, M. Jia, L. Yu, K. | Curr Med Res Opin | 2018 |
Sedative drugs |
| Prediction of length of hospital stay and mortality in patients with delirium: A prospective cohort analysis of 200 ICU patients. | Tian, J. Chen, X. Liu, D. | Journal of Biological Regulators and Homeostatic Agents | 2018 |
adult |
| Ramelteon is Not Associated With Improved Outcomes Among Critically Ill Delirious Patients: A Single-Center Retrospective Cohort Study. | Thom, R. Bui, M. Rosner, B. Teslyar, P. Levy-Carrick, N. Wolfe, D. Klompas, M. | Psychosomatics | 2018 |
Delirium |
| A daily multidisciplinary assessment of older adults undergoing elective colorectal cancer surgery is associated with reduced delirium and geriatric syndromes. | Tarazona-Santabalbina, F. J. Llabata-Broseta, J. Belenguer-Varea, A. Alvarez-Martinez, D. Cuesta-Peredo, D. Avellana-Zaragoza, J. A. | J Geriatr Oncol | 2018 |
Colorectal surgery |
| Preventive Effect of Suvorexant for Postoperative Delirium after Coronary Artery Bypass Grafting. | Tamura, K. Maruyama, T. Sakurai, S. | Ann Thorac Cardiovasc Surg | 2018 |
Suvorexant |
| Aproach to the risk of delirium in an orthogeriatric unit. | Sopena Bert, E. Qanneta, R. Valenti Moreno, V. San Jose Laporte, A. | Med Clin | 2018 |
Delirium |
| A systematic review of the use of music interventions to improve outcomes for patients undergoing hip or knee surgery. | Sibanda, A. Carnes, D. Visentin, D. Cleary, M. | J Adv Nurs | 2018 |
anxiety |
| Use of "Months of the Year Backwards" (MOTYB) as a Screening Tool for Delirium in Palliative Care Patients in the Acute Hospital Setting. | Ryan, S. Hayes, D. Creedon, B. | Ir Med J | 2018 | |
| Impact of psychotic symptoms on clinical outcomes in delirium. | Paik, S. H. Ahn, J. S. Min, S. Park, K. C. Kim, M. H. | PLoS ONE | 2018 |
neuroleptic agent |
| Preoperative age and prognostic nutritional index are useful factors for evaluating postoperative delirium among patients with adult spinal deformity. | Oe, S. Togawa, D. Yamato, Y. Hasegawa, T. Yoshida, G. Kobayashi, S. Yasuda, T. Banno, T. Arima, H. Mihara, Y. Ushirozako, H. Yamada, T. Matsuyama, Y. | Spine | 2018 | |
| Decreased Risk of Delirium With Use of Regional Analgesia in Geriatric Trauma Patients With Multiple Rib Fractures. | O'Connell, K. M. Quistberg, D. A. Tessler, R. Robinson, B. R. H. Cuschieri, J. Maier, R. V. Rivara, F. P. Vavilala, M. S. Bhalla, P. I. Arbabi, S. | Ann Surg | 2018 |
OBJECTIVE: The aim of this study was to examine the risk of delirium in geriatric trauma patients with rib fractures treated with systemic opioids compared with those treated with regional analgesia (RA). SUMMARY OF BACKGROUND DATA: Delirium is a modifiable complication associated with increased morbidity and mortality. RA may reduce the need for opioid medications, which are associated with delirium in older adults. METHODS: Cohort study of patients >/=65 years admitted to a regional trauma center from 2011 to 2016. Inclusion factors were >/= 3 rib fractures, blunt trauma mechanism, and admission to intensive care unit (ICU). Exclusion criteria included head AIS >/=3, spine AIS >/=3, dementia, and death within 24 hours. The primary outcome was delirium positive ICU days, defined using the CAM-ICU assessment. Delirium incident rate ratios (IRRs) and 95% confidence intervals (95% CIs) were estimated using generalized linear mixed models with Poisson distribution and robust standard errors. RESULTS: Of the 144 patients included in the study, 27 (19%) received Acute Pain Service consultation and RA and 117 (81%) received opioid-based systemic analgesia. Patients with RA had more severe chest injury than those without. The risk of delirium decreased by 24% per day per patient with use of RA (IRR 0.76, 95% CI 0.61 to 0.96). Individual opioid use, as measured in daily morphine equivalents (MEDs), was significantly reduced after initiation of RA (mean difference -7.62, 95% CI -14.4 to -0.81). CONCLUSION: Although use of RA techniques in geriatric trauma patients with multiple rib fractures was associated with higher MED, opioid use decreased after RA initiation and Acute Pain Service consultation, and the risk of delirium was lower. |
| Hypotension and a positive fluid balance are associated with delirium in patients with shock. | Nguyen, D. N. Huyghens, L. Parra, J. Schiettecatte, J. Smitz, J. Vincent, J. L. | PLoS One | 2018 | |
| End-Tidal Hypocapnia Under Anesthesia Predicts Postoperative Delirium. | Mutch, W. A. C. El-Gabalawy, R. Girling, L. Kilborn, K. Jacobsohn, E. | Front Neurol | 2018 |
*anesthetic agent |
| Risk Factors for Delirium after Spine Surgery: An Age-Matched Analysis. | Morino, T. Hino, M. Yamaoka, S. Misaki, H. Ogata, T. Imai, H. Miura, H. | Asian Spine J | 2018 |
Delirium |
| Outcomes of Patients With Delirium in Long-Term Care Facilities: A Prospective Cohort Study. | Moon, K. J. Park, H. | J Gerontol Nurs | 2018 |
Aged |
| Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery. | Miller, D. Lewis, S. R. Pritchard, M. W. Schofield-Robinson, O. J. Shelton, C. L. Alderson, P. Smith, A. F. | Cochrane Database of Systematic Reviews | 2018 |
Aged |
| Incidence, risk factors and clinical impact of postoperative delirium following open reduction and internal fixation (ORIF) for hip fractures: an analysis of 7859 patients from the ACS-NSQIP hip fracture procedure targeted database. | Malik, A. T. Quatman, C. E. Phieffer, L. S. Ly, T. V. Khan, S. N. | Eur J Orthop Surg Traumatol | 2018 |
Delirium |
| Delirium After Cardiac Surgery and Cumulative Fluid Balance: A Case-Control Cohort Study. | Mailhot, T. Cossette, S. Lambert, J. Beaubien-Souligny, W. Cournoyer, A. O'Meara, E. Maheu-Cadotte, M. A. Fontaine, G. Bouchard, J. Lamarche, Y. Benkreira, A. Rochon, A. Denault, A. | J Cardiothorac Vasc Anesth | 2019 |
cardiac surgery |
| The point-of-care EEG for delirium detection in the emergency department. | Lee, S. Yuki, K. Chan, A. Cromwell, J. Shinozaki, G. | Am J Emerg Med | 2018 |
Bispectral EEG |
| Intraoperative hypotension is not associated with postoperative cognitive dysfunction in elderly patients undergoing general anesthesia for surgery: results of a randomized controlled pilot trial. | Langer, T. Santini, A. Zadek, F. Chiodi, M. Pugni, P. Cordolcini, V. Bonanomi, B. Rosini, F. Marcucci, M. Valenza, F. Marenghi, C. Inglese, S. Pesenti, A. Gattinoni, L. | J Clin Anesth | 2019 |
Anesthesia, general |
| Differences in healthcare outcomes between teaching and non teaching hospitals for patients with delirium: a retrospective cohort study. | Kotwal, S. Abougergi, M. S. Wright, S. | Int J Qual Health Care | 2018 | |
| Gender differences in the use of atypical antipsychotic medications for ICU delirium. | Karamchandani, K. Schoaps, R. S. Printz, J. Kowaleski, J. M. Carr, Z. J. | Crit Care | 2018 | |
| Whole-Genome mRNA Gene Expression Differs Between Patients With and Without Delirium. | Kalantar, K. LaHue, S. C. DeRisi, J. L. Sample, H. A. Contag, C. A. Josephson, S. A. Wilson, M. R. Douglas, V. C. | Journal of Geriatric Psychiatry and Neurology | 2018 |
integrin |
| Incidence and risk factors of subsyndromal delirium after curative resection of gastric cancer. | Hwang, H. Lee, K. M. Son, K. L. Jung, D. Kim, W. H. Lee, J. Y. Kong, S. H. Suh, Y. S. Lee, H. J. Yang, H. K. Hahm, B. J. | BMC Cancer | 2018 |
adult |
| Performance of Electronic Prediction Rules for Prevalent Delirium at Hospital Admission. | Halladay, C. W. Sillner, A. Y. Rudolph, J. L. | JAMA Netw Open | 2018 | |
| Harmonization of delirium severity instruments: a comparison of the DRS-R-98, MDAS, and CAM-S using item response theory. | Gross, A. L. Tommet, D. D'Aquila, M. Schmitt, E. Marcantonio, E. R. Helfand, B. Inouye, S. K. Jones, R. N. | BMC Med Res Methodol | 2018 |
Delirium |
| Prognostic factors of inhospital death in elderly patients: A time-to-event analysis of a cohort study in Martinique (French West Indies). | Godaert, L. Bartholet, S. Dorléans, F. Najioullah, F. Colas, S. Fanon, J. L. Cabié, A. Césaire, R. Dramé, M. | BMJ Open | 2018 |
aged |
| The Critical Vital Sign of Cognitive Health and Delirium: Whose Responsibility Is It? | Fick, D. M. | J Gerontol Nurs | 2018 | |
| Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. | Devlin, J. W. Skrobik, Y. Gelinas, C. Needham, D. M. Slooter, A. J. C. Pandharipande, P. P. Watson, P. L. Weinhouse, G. L. Nunnally, M. E. Rochwerg, B. Balas, M. C. van den Boogaard, M. Bosma, K. J. Brummel, N. E. Chanques, G. Denehy, L. Drouot, X. Fraser | Crit Care Med | 2018 | |
| Delirium etiology subtypes and their effect on six-month function and cognition in older emergency department patients. | Cirbus, J. MacLullich, A. M. J. Noel, C. Ely, E. W. Chandrasekhar, R. Han, J. H. | International Psychogeriatrics | 2018 |
aged |
| Perioperative Sedation in Mechanically Ventilated Cardiac Surgery Patients With Dexmedetomidine-Based Versus Propofol-Based Regimens. | Chuich, T. Cropsey, C. L. Shi, Y. Johnson, D. Shotwell, M. S. Henson, C. P. | Ann Pharmacother | 2019 |
anesthesia |
| Hospital discharge data under-reports delirium occurrence. Results from a point prevalence survey of delirium in a major Australian health service. | Casey, P. Cross, W. Webb-St Mart, M. Baldwin, C. Riddell, K. Darzins, P. | Intern Med J | 2018 |
Adult |
| TIME to think about delirium: improving detection and management on the acute medical unit. | Bauernfreund, Y. Butler, M. Ragavan, S. Sampson, E. L. | BMJ Open Qual | 2018 |
Pdsa |
| The Association of Delirium with Perioperative Complications in Primary Elective Total Hip Arthroplasty. | Aziz, K. T. Best, M. J. Naseer, Z. Skolasky, R. L. Ponnusamy, K. E. Sterling, R. S. Khanuja, H. S. | Clin Orthop Surg | 2018 |
Aged |
| Bispectral Index Monitoring During Anesthesia Promotes Early Postoperative Recovery of Cognitive Function and Reduces Acute Delirium in Elderly Patients with Colon Carcinoma: A Prospective Controlled Study using the Attention Network Test. | Zhou, Y. Li, Y. Wang, K. | Med Sci Monit | 2018 |
Aged |
| Military Service Members and Emergence Delirium Screening: An Evidence-Based Practice Project. | Wheat, L. L., 2nd Turner, B. S. Diaz, A. Maani, C. V. | J Perianesth Nurs | 2018 |
emergence delirium |
| Can delirium research activity impact on routine delirium recognition? A prospective cohort study. | Welch, C. Jackson, T. A. | BMJ Open | 2018 |
dementia |
| Preoperative STOP-BANG Scores and Postoperative Delirium and Coma in Thoracic Surgery Patients. | Wang, S. Sigua, N. L. Manchanda, S. Gradney, S. Khan, S. H. Perkins, A. Kesler, K. Khan, B. | Ann Thorac Surg | 2018 | |
| The Cost of ICU Delirium and Coma in the Intensive Care Unit Patient. | Vasilevskis, E. E. Chandrasekhar, R. Holtze, C. H. Graves, J. Speroff, T. Girard, T. D. Patel, M. B. Hughes, C. G. Cao, A. Pandharipande, P. P. Ely, E. W. | Med Care | 2018 | |
| Pharmacologic prevention of postoperative delirium after on-pump cardiac surgery: A meta-analysis of randomized trials. | Tao, R. Wang, X. W. Pang, L. J. Cheng, J. Wang, Y. M. Gao, G. Q. Liu, Y. Wang, C. | Medicine | 2018 |
Antipsychotic Agents/*therapeutic use |
| Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging. | Shinozaki, G. Braun, P. R. Hing, B. W. Q. Ratanatharathorn, A. Klisares, M. J. Duncan, G. N. Jellison, S. S. Heinzman, J. T. Nagahama, Y. Close, L. Sabbagh, S. Dlouhy, B. J. Howard, M. A. Kawasaki, H. Cho, H. R. | Front Aging Neurosci | 2018 |
DNA methylation |
| The Hospital Elder Life Program: Past and Future. | Scheunemann, L. P. Girard, T. D. Skidmore, E. R. Resnick, N. M. | Am J Geriatr Psychiatry | 2018 | |
| Delirium in the Acute Phase of Ischemic Stroke: Incidence, Risk Factors, and Effects on Functional Outcome. | Qu, J. Chen, Y. Luo, G. Zhong, H. Xiao, W. Yin, H. | J Stroke Cerebrovasc Dis | 2018 |
Activities of Daily Living |
| Effect of dynamic light at the coronary care unit on the length of hospital stay and development of delirium: A retrospective cohort study. | Pustjens, T. Schoutens, A. M. C. Janssen, L. Heesen, W. F. | Journal of Geriatric Cardiology | 2018 |
neuroleptic agent |
| Frailty and Delirium in Older Adults: A Systematic Review and Meta-Analysis of the Literature. | Persico, I. Cesari, M. Morandi, A. Haas, J. Mazzola, P. Zambon, A. Annoni, G. Bellelli, G. | J Am Geriatr Soc | 2018 |
cognition |
| Medications and Patient Characteristics Associated With Falling in the Hospital. | OʼNeil, C. A. Krauss, M. J. Bettale, J. Kessels, A. Costantinou, E. Dunagan, W. C. Fraser, V. J. | Journal of Patient Safety | 2018 |
adult |
| Delirium detection using relative delta power based on 1-minute single-channel EEG: a multicentre study. | Numan, T. van den Boogaard, M. Kamper, A. M. Rood, P. J. T. Peelen, L. M. Slooter, A. J. C. | Br J Anaesth | 2018 |
complications, postoperative |
| Low skeletal muscle mass as a risk factor for postoperative delirium in elderly patients undergoing colorectal cancer surgery. | Mosk, C. A. L. A. van Vugt J de Jonge, H. Witjes, C. D. Buettner, S. Ijzermans, J. N. van der Laan, L. | Clin Interv Aging | 2018 |
Aged |
| Symptom expression in advanced cancer patients admitted to hospice or home care with and without delirium. | Mercadante, S. Masedu, F. Maltoni, M. De Giovanni, D. Montanari, L. Pittureri, C. Berte, R. Russo, D. Ursini, L. Marinangeli, F. Aielli, F. | Intern Emerg Med | 2018 |
Advanced cancer |
| Symptom Expression in Patients with Advanced Cancer Admitted to an Acute Supportive/Palliative Care Unit With and Without Delirium. | Mercadante, S. Adile, C. Ferrera, P. Cortegiani, A. Casuccio, A. | Oncologist | 2018 |
Advanced cancer |
| Pain, agitation and delirium assessment and management in a community medical-surgical ICU: results from a prospective observational study and nurse survey. | Maximous, R. Miller, F. Tan, C. Camargo, M. Ross, K. Marshall, C. Yung, P. Fleming, D. Law, M. Tsang, J. L. Y. | BMJ Open Qual | 2018 |
attitudes |
| Evaluating the risk profile of quetiapine in treating delirium in the intensive care adult population: A retrospective review. | Mangan, K. C. McKinzie, B. P. Deloney, L. P. Leon, S. M. Eriksson, E. A. | J Crit Care | 2018 |
Delirium |
| Cerebral monitoring of anaesthesia on reducing cognitive dysfunction and postoperative delirium: a systematic review. | Luo, C. Zou, W. | J Int Med Res | 2018 |
Anesthesia/*adverse effects/methods |
| Dysfunctional cerebral autoregulation is associated with delirium in critically ill adults. | Lee, K. F. Wood, M. D. Maslove, D. M. Muscedere, J. G. Boyd, J. G. | J Cereb Blood Flow Metab | 2018 |
Cerebral autoregulation |
| Defining delirium in idiopathic Parkinson's disease: A systematic review. | Lawson, R. A. McDonald, C. Burn, D. J. | Parkinsonism and Related Disorders | 2018 |
adult |
| Delirium assessment in neuro-critically ill patients: A validation study. | Larsen, L. K. Frokjaer, V. G. Nielsen, J. S. Skrobik, Y. Winkler, Y. Moller, K. Petersen, M. Egerod, I. | Acta Anaesthesiol Scand | 2018 |
acute brain injury |
| Benzodiazepine Use and Neuropsychiatric Outcomes in the ICU: A Systematic Review | Kok, L. Slooter, A. J. Hillegers, M. H. van Dijk, D. Veldhuijzen, D. S. | Crit Care Med | 2018 | |
| Hospital Elder Life Program: Systematic Review and Meta-analysis of Effectiveness | Hshieh, T. T. Yang, T. Gartaganis, S. L. Yue, J. Inouye, S. K. | Am J Geriatr Psychiatry | 2018 |
Delirium prevention |
| Predictive Modeling for Geriatric Hip Fracture Patients: Early Surgery and Delirium Have the Largest Influence on Length of Stay. | Hecht, G. Slee, C. A. Goodell, P. B. Taylor, S. L. Wolinsky, P. R. | J Am Acad Orthop Surg | 2018 | |
| The Erasmus Frailty Score is associated with delirium and 1-year mortality after Transcatheter Aortic Valve Implantation in older patients. The TAVI Care & Cure program. | Goudzwaard, J. A. de Ronde-Tillmans, Mjag El Faquir, N. Acar, F. Van Mieghem, N. M. Lenzen, M. J. de Jaegere, P. P. T. Mattace-Raso, F. U. S. | Int J Cardiol | 2019 |
Delirium |
| Transcutaneous electrical acupoint stimulation for prevention of postoperative delirium in geriatric patients with silent lacunar infarction: a preliminary study. | Gao, F. Zhang, Q. Li, Y. Tai, Y. Xin, X. Wang, X. Wang, Q. | Clin Interv Aging | 2018 |
*Acupuncture Points |
| Dexmedetomidine in prevention and treatment of postoperative and intensive care unit delirium: a systematic review and meta-analysis. | Flükiger, J. Hollinger, A. Speich, B. Meier, V. Tontsch, J. Zehnder, T. Siegemund, M. | Annals of Intensive Care | 2018 |
dexmedetomidine |
| Long-term prognostic value of delirium in elderly patients with acute cardiac diseases admitted to two cardiac intensive care units: a prospective study (DELIRIUM CORDIS). | Falsini, G. Grotti, S. Porto, I. Toccafondi, G. Fraticelli, A. Angioli, P. Ducci, K. Liistro, F. Pieroni, M. Taddei, T. Romanelli, S. Rossi, R. Bolognese, L. | Eur Heart J Acute Cardiovasc Care | 2018 |
Acute Disease |
| Persistent Delirium in Elderly patients Three Months After Hospital Discharge from a University Clinic. | Constaín, G. A. Ocampo Saldarriaga, M. V. Velásquez Tirado, J. D. Rodríguez-Gázquez, M. D. L. Á Betancur Morales, L. M. Rico Escobar, J. J. Castilla Agudelo, G. A. Maya Osorno, A. F. | Revista Colombiana de Psiquiatria | 2018 |
aged |
| A Web-Based Serious Game on Delirium as an Educational Intervention for Medical Students: Randomized Controlled Trial. | Buijs-Spanjers, K. R. Hegge, H. H. Jansen, C. J. Hoogendoorn, E. de Rooij, S. E. | JMIR Serious Games | 2018 |
delirium |
| Relationship Between Near-Infrared Spectroscopy-Derived Cerebral Oxygenation and Delirium in Critically Ill Patients: A Systematic Review. | Bendahan, N. Neal, O. Ross-White, A. Muscedere, J. Boyd, J. G. | J Intensive Care Med | 2018 |
Cam-icu |
| Ability of suvorexant to prevent delirium in patients in the intensive care unit: a randomized controlled trial. | Azuma, K. Takaesu, Y. Soeda, H. Iguchi, A. Uchida, K. Ohta, S. Mishima, S. Inoue, T. Inoue, Y. Oda, J. | Acute Med Surg | 2018 |
Delirium |
| Incidence of postoperative delirium in elderly ambulatory patients: A prospective evaluation using the FAM-CAM instrument. | Aya, A. G. M. Pouchain, P. H. Thomas, H. Ripart, J. Cuvillon, P. | J Clin Anesth | 2018 |
Ambulatory surgery |
| Potential Role of Exogenous Melatonin Supplement in Delirium Prevention in Critically Ill Patients: A Double-Blind Randomized Pilot Study. | Abbasi, S. Farsaei, S. Ghasemi, D. Mansourian, M. | Iran J Pharm Res | 2018 |
Clinical trial |
| Predictive nomogram for postoperative delirium in elderly patients with a hip fracture. | Zhang, X. Tong, D. K. Ji, F. Duan, X. Z. Liu, P. Z. Qin, S. Xu, K. H. Di-li, X. T. | Injury | 2018 |
aged |
| Advances in dementia with Lewy bodies | Armstrong, M. J. | Ther Adv Neurol Disord | 2021 |
Lewy body dementia |
| Factors Influencing CAM-ICU Documentation and Inappropriate "Unable to Assess" Responses | Awan, O. M. Buhr, R. G. Kamdar, B. B. | Am J Crit Care | 2021 |
Aged, 80 and over |
| Prediction of Postictal Delirium Following Status Epilepticus in the ICU: First Insights of an Observational Cohort Study | Baumann, S. M. Semmlack, S. Hunziker, S. Kaplan, P. W. De Marchis, G. M. Rüegg, S. Marsch, S. Sutter, R. | Crit Care Med | 2021 |
Aged |