What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Exercise for acutely hospitalised older medical patients
- Authors
- Hartley, P. Keating, J. L. Jeffs, K. J. Raymond, M. J. Smith, T. O
- Year
- 2022
- Journal
- Cochrane Database Syst Rev
- Abstract
BACKGROUND: Approximately 30% of hospitalised older adults experience hospital-associated functional decline. Exercise interventions that promote in-hospital activity may prevent deconditioning and thereby maintain physical function during hospitalisation. This is an update of a Cochrane Review first published in 2007. OBJECTIVES: To evaluate the benefits and harms of exercise interventions for acutely hospitalised older medical inpatients on functional ability, quality of life (QoL), participant global assessment of success and adverse events compared to usual care or a sham-control intervention. SEARCH METHODS: We used standard, extensive Cochrane search methods. The latest search date was May 2021. SELECTION CRITERIA: We included randomised or quasi-randomised controlled trials evaluating an in-hospital exercise intervention in people aged 65 years or older admitted to hospital with a general medical condition. We excluded people admitted for elective reasons or surgery. DATA COLLECTION AND ANALYSIS: We used standard Cochrane methods. Our major outcomes were 1. independence with activities of daily living; 2. functional mobility; 3. new incidence of delirium during hospitalisation; 4. QoL; 5. number of falls during hospitalisation; 6. medical deterioration during hospitalisation and 7. participant global assessment of success. Our minor outcomes were 8. death during hospitalisation; 9. musculoskeletal injuries during hospitalisation; 10. hospital length of stay; 11. new institutionalisation at hospital discharge; 12. hospital readmission and 13. walking performance. We used GRADE to assess certainty of evidence for each major outcome. We categorised exercise interventions as: rehabilitation-related activities (interventions designed to increase physical activity or functional recovery, but did not follow a specified exercise protocol); structured exercise (interventions that included an exercise intervention protocol but did not include progressive resistance training); and progressive resistance exercise (interventions that included an element of progressive resistance training). MAIN RESULTS: We included 24 studies (nine rehabilitation-related activity interventions, six structured exercise interventions and nine progressive resistance exercise interventions) with 7511 participants. All studies compared exercise interventions to usual care; two studies, in addition to usual care, used sham interventions. Mean ages ranged from 73 to 88 years, and 58% of participants were women. Several studies were at high risk of bias. The most common domain assessed at high risk of bias was measurement of the outcome, and five studies (21%) were at high risk of bias arising from the randomisation process. Exercise may have no clinically important effect on independence in activities of daily living at discharge from hospital compared to controls (16 studies, 5174 participants; low-certainty evidence). Five studies used the Barthel Index (scale: 0 to 100, higher scores representing greater independence). Mean scores at discharge in the control groups ranged from 42 to 96 points, and independence in activities of daily living was 1.8 points better (0.43 worse to 4.12 better) with exercise compared to controls. The minimally clinical important difference (MCID) is estimated to be 11 points. We are uncertain regarding the effect of exercise on functional mobility at discharge from the hospital compared to controls (8 studies, 2369 participants; very low-certainty evidence). Three studies used the Short Physical Performance Battery (SPPB) (scale: 0 to 12, higher scores representing better function) to measure functional mobility. Mean scores at discharge in the control groups ranged from 3.7 to 4.9 points on the SPPB, and the estimated effect of the exercise interventions was 0.78 points better (0.02 worse to 1.57 better). A change of 1 point on the SPPB represents an MCID. We are uncertain regarding the effect of exercise on the incidence of delirium during hospitalisation compared to controls (7 trials, 2088 participants; very low-certainty evidence). The incidence of delirium during hospitalisation was 88/1091 (81 per 1000) in the control group compared with 70/997 (73 per 1000; range 47 to 114) in the exercise group (RR 0.90, 95% CI 0.58 to 1.41). Exercise interventions may result in a small clinically unimportant improvement in QoL at discharge from the hospital compared to controls (4 studies, 875 participants; low-certainty evidence). Mean QoL on the EuroQol 5 Dimensions (EQ-5D) visual analogue scale (VAS) (scale: 0 to 100, higher scores representing better QoL) ranged between 48.9 and 64.7 in the control group at discharge from the hospital, and QoL was 6.04 points better (0.9 better to 11.18 better) with exercise. A change of 10 points on the EQ-5D VAS represents an MCID. No studies measured participant global assessment of success. Exercise interventions did not affect the risk of falls during hospitalisation (moderate-certainty evidence). The incidence of falls was 31/899 (34 per 1000) in the control group compared with 31/888 (34 per 1000; range 20 to 57) in the exercise group (RR 0.99, 95% CI 0.59 to 1.65). We are uncertain regarding the effect of exercise on the incidence of medical deterioration during hospitalisation (very low-certainty evidence). The incidence of medical deterioration in the control group was 101/1417 (71 per 1000) compared with 96/1313 (73 per 1000; range 44 to 120) in the exercise group (RR 1.02, 95% CI 0.62 to 1.68). Subgroup analyses by different intervention categories and by the use of a sham intervention were not meaningfully different from the main analyses. AUTHORS’ CONCLUSIONS: Exercise may make little difference to independence in activities of daily living or QoL, but probably does not result in more falls in older medical inpatients. We are uncertain about the effect of exercise on functional mobility, incidence of delirium and medical deterioration. Certainty of evidence was limited by risk of bias and inconsistency. Future primary research on the effect of exercise on acute hospitalisation could focus on more consistent and uniform reporting of participant’s characteristics including their baseline level of functional ability, as well as exercise dose, intensity and adherence that may provide an insight into the reasons for the observed inconsistencies in findings.
- PMID
- Keywords
Aged
Aged, 80 and over
Female
Humans
Male
Activities of Daily Living
*Delirium/epidemiology
Exercise
*Quality of Life
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Training students to detect delirium: An interprofessional pilot study | Chambers, B. Meyer, M. Peterson, M. | Nurse Educ Today | 2018 |
Attitude of Health Personnel |
| Antipsychotics for treatment of delirium in hospitalised non-ICU patients | Burry, L. Mehta, S. Perreault, M. M. Luxenberg, J. S. Siddiqi, N. Hutton, B. Fergusson, D. A. Bell, C. Rose, L. | Cochrane Database of Systematic Reviews | 2018 | |
| The association of indwelling urinary catheter with delirium in hospitalized patients and nursing home residents: an explorative analysis from the "Delirium Day 2015". | Bo, M. Porrino, P. Di Santo, S. G. Mazzone, A. Cherubini, A. Mossello, E. Bianchetti, A. Musicco, M. Ferrari, A. Ferrara, N. Filippini, C. Trabucchi, M. Morandi, A. Bellelli, G. | Aging Clin Exp Res | 2018 |
4AT test |
| Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly: 3-Year Follow-up of a Randomized Controlled Trial. | Zhang, D. F. Su, X. Meng, Z. T. Li, H. L. Wang, D. X. Li, X. Y. Maze, M. Ma, D. | Ann Surg | 2018 | |
| Anticholinergic medications in patients admitted with cognitive impairment or falls (AMiCI). The impact of hospital admission on anticholinergic cognitive medication burden. Results of a multicentre observational study. | Weichert, I. Romero-Ortuno, R. Tolonen, J. Soe, T. Lebus, C. Choudhury, S. Nadarajah, C. V. Nanayakkara, P. Orru, M. Di Somma, S. | J Clin Pharm Ther | 2018 |
anticholinergic cognitive burden |
| Delirium prediction in the intensive care unit: comparison of two delirium prediction models. | Wassenaar, A. Schoonhoven, L. Devlin, J. W. van Haren, F. M. P. Slooter, A. J. C. Jorens, P. G. van der Jagt, M. Simons, K. S. Egerod, I. Burry, L. D. Beishuizen, A. Matos, J. Donders, A. R. T. Pickkers, P. van den Boogaard, M. | Crit Care | 2018 |
Adult |
| Clinical Utility of a Structured Program to Reduce the Risk of Health-Related Quality of Life Impairment after Discharge from Intensive Care Unit: A Real-World Experience. | Venni, A. Ioia, F. Laviola, S. Frigieri, F. Pieri, A. Marilli, S. Balzi, D. Ballo, P. Gori, S. Guarducci, D. | Crit Care Res Pract | 2018 | |
| Perioperative predictors of delirium and incidence factors in adult patients post cardiac surgery. | Theologou, S. Giakoumidakis, K. Charitos, C. | Pragmat Obs Res | 2018 |
delirium biomarkers |
| Evaluating the implementation of confusion assessment method-intensive care unit using a quality improvement approach. | Stewart, C. Bench, S. | Nurs Crit Care | 2018 |
Clinical audit |
| Temporal biomarker profiles and their association with ICU acquired delirium: a cohort study. | Simons, K. S. van den Boogaard, M. Hendriksen, E. Gerretsen, J. van der Hoeven, J. G. Pickkers, P. de Jager, C. P. C. | Crit Care | 2018 |
Biomarkers |
| Delirium after cardiac surgery. Incidence, phenotypes, predisposing and precipitating risk factors, and effects. | Sanson, G. Khlopenyuk, Y. Milocco, S. Sartori, M. Dreas, L. Fabiani, A. | Heart Lung | 2018 |
Cardiac surgery |
| Educational Intervention on Delirium Assessment Using Confusion Assessment Method-ICU (CAM-ICU) in a General Intensive Care Unit. | Ramoo, V. Abu, H. Rai, V. Surat Singh, S. K. Baharudin, A. A. Danaee, M. Thinagaran, R. R. R. | J Clin Nurs | 2018 |
Cam-icu |
| Delirium Burden in Patients and Family Caregivers: Development and Testing of New Instruments. | Racine, A. M. D'Aquila, M. Schmitt, E. M. Gallagher, J. Marcantonio, E. R. Jones, R. N. Inouye, S. K. Schulman-Green, D. | Gerontologist | 2018 | |
| Processed electroencephalogram and evoked potential techniques for amelioration of postoperative delirium and cognitive dysfunction following non-cardiac and non-neurosurgical procedures in adults. | Punjasawadwong, Y. Chau-In, W. Laopaiboon, M. Punjasawadwong, S. Pin-On, P. | Cochrane Database of Systematic Reviews | 2018 | |
| Influence of physical restraint on delirium of adult patients in ICU: A nested case–control study. | Pan, Yanbin Jiang, Zhixia Yuan, Changrong Wang, Lianhong Zhang, Jingjing Zhou, Jing Tao, Ming Quan, Mingtao Wu, Qiong | Journal of Clinical Nursing | 2018 |
Restraint, Physical — Adverse Effects |
| Development of a Novel Self-administered Cognitive Assessment Tool and Normative Data for Older Adults. | Monsch, R. J. Burckhardt, A. C. Berres, M. Thomann, A. E. Ehrensperger, M. M. Steiner, L. A. Goettel, N. | J Neurosurg Anesthesiol | 2018 | |
| Cooccurrence of Post-Intensive Care Syndrome Problems Among 406 Survivors of Critical Illness. | Marra, A. Pandharipande, P. P. Girard, T. D. Patel, M. B. Hughes, C. G. Jackson, J. C. Thompson, J. L. Chandrasekhar, R. Ely, E. W. Brummel, N. E. | Crit Care Med | 2018 | |
| Precipitants of Delirium in Older Inpatients Admitted in Surgery for Post-Fall Hip Fracture: An Observational Study. | Levinoff, E. Try, A. Chabot, J. Lee, L. Zukor, D. Beauchet, O. | The Journal of Frailty & Aging | 2018 |
aged |
| Neural predisposing factors of postoperative delirium in elderly patients with femoral neck fracture. | Kyeong, S. Shin, J. E. Yang, K. H. Lee, W. S. Chung, T. S. Kim, J. J. | Sci Rep | 2018 | |
| Music intervention to prevent delirium among older patients admitted to a trauma intensive care unit and a trauma orthopaedic unit. | Johnson, K. Fleury, J. McClain, D. | Intensive Crit Care Nurs | 2018 |
Delirium |
| Delirium as a predictor of mortality in US Medicare beneficiaries discharged from the emergency department: a national claims-level analysis up to 12 months. | Israni, J. Lesser, A. Kent, T. Ko, K. | BMJ Open | 2018 |
claims data |
| An evaluation of patient-specific characteristics on attainment of target sedation in an intensive care unit. | Humphrey, M. Everhart, S. Kosmisky, D. Anderson, W. E. | Heart Lung | 2018 |
Agitation |
| An assistant workforce to improve screening rates and quality of care for older patients in the emergency department: findings of a pre- post, mixed methods study. | Hullick, C. Conway, J. Higgins, I. Hewitt, J. Stewart, B. Dilworth, S. Attia, J. | BMC Geriatr | 2018 |
Assessment, nursing |
| Cycling of Dexmedetomidine May Prevent Delirium After Liver Transplantation. | Hong, K. S. Kim, N. R. Song, S. H. Hong, G. | Transplant Proc | 2018 | |
| Risk Factors for Postoperative Delirium After Gastrectomy in Gastric Cancer Patients. | Honda, S. Furukawa, K. Nishiwaki, N. Fujiya, K. Omori, H. Kaji, S. Makuuchi, R. Irino, T. Tanizawa, Y. Bando, E. Kawamura, T. Terashima, M. | World J Surg | 2018 | |
| Factors Associated with the Effectiveness of Intravenous Administration of Chlorpromazine for Delirium in Patients with Terminal Cancer. | Hasuo, H. Kanbara, K. Fujii, R. Uchitani, K. Sakuma, H. Fukunaga, M. | J Palliat Med | 2018 |
delirium |
| An evaluation of single question delirium screening tools in older emergency department patients. | Han, J. H. Wilson, A. Schnelle, J. F. Dittus, R. S. Wesley Ely, E. | American Journal of Emergency Medicine | 2018 |
adult |
| A contemporary population-based analysis of the incidence, cost, and outcomes of postoperative delirium following major urologic cancer surgeries. | Ha, A. Krasnow, R. E. Mossanen, M. Nagle, R. Hshieh, T. T. Rudolph, J. L. Chang, S. L. | Urol Oncol | 2018 |
Costs |
| Risk Factors and Outcomes of Delirium in Older Patients Admitted to Postacute Care with and without Dementia. | Gual, N. Morandi, A. Perez, L. M. Britez, L. Burbano, P. Man, F. Inzitari, M. | Dement Geriatr Cogn Disord | 2018 |
Crisis management |
| Frailty Assessment to Help Predict Patients at Risk of Delirium When Consulting the Emergency Department. | Giroux, M. Sirois, M. J. Boucher, V. Daoust, R. Gouin, E. Pelletier, M. Berthelot, S. Voyer, P. Emond, M. | J Emerg Med | 2018 |
delirium |
| Performance of the French version of the 4AT for screening the elderly for delirium in the emergency department. | Gagne, A. J. Voyer, P. Boucher, V. Nadeau, A. Carmichael, P. H. Pelletier, M. Gouin, E. Berthelot, S. Daoust, R. Wilchesky, M. Richard, H. Pelletier, I. Ballard, S. Lague, A. Emond, M.` | CJEM | 2018 | |
| Early rehabilitation to prevent postintensive care syndrome in patients with critical illness: a systematic review and meta-analysis | Fuke, R. Hifumi, T. Kondo, Y. Hatakeyama, J. Takei, T. Yamakawa, K. Inoue, S. Nishida, O. | BMJ Open | 2018 |
early rehabilitation |
| Effects of closed-loop intravenous anesthesia guided by Bispectral Index in adult patients on emergence delirium: A randomized controlled study. | Cotoia, A. Mirabella, L. Beck, R. Matrella, P. Assenzo, V. Hazot, T. C. Cinnella, G. Liu, N. Dambrosio, M. | Minerva Anestesiol | 2018 |
epidural catheter |
| Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study. | Collet, M. O. Caballero, J. Sonneville, R. Bozza, F. A. Nydahl, P. Schandl, A. Woien, H. Citerio, G. van den Boogaard, M. Hastbacka, J. Haenggi, M. Colpaert, K. Rose, L. Barbateskovic, M. Lange, T. Jensen, A. Krog, M. B. Egerod, I. Nibro, H. L. Wetterslev | Intensive Care Med | 2018 |
Cohort |
| Latent class analysis of the multivariate Delirium Index in long-term care settings. | Ciampi, A. Bai, C. Dyachenko, A. McCusker, J. Cole, M. G. Belzile, E. | Int Psychogeriatr | 2018 |
Delirium Index |
| Cognitive Decline after Delirium in Patients Undergoing Cardiac Surgery. | Brown, C. H. th Probert, J. Healy, R. Parish, M. Nomura, Y. Yamaguchi, A. Tian, J. Zehr, K. Mandal, K. Kamath, V. Neufeld, K. J. Hogue, C. W. | Anesthesiology | 2018 | |
| Screening for Delirium: Development and Validation of the Buffalo Delirium Scale for Use in a Home-Based Hospice Setting. | Breier, J. M. Meier, S. T. Kerr, C. W. Wright, S. T. Grant, P. C. Depner, R. M. | Am J Hosp Palliat Care | 2018 |
delirium |
| Improving Geriatric Care Processes on Two Medical-Surgical Acute Care Units: A Pilot Study. | Booth, K. A. Simmons, E. E. Viles, A. F. Gray, W. A. Kennedy, K. R. Biswal, S. H. Lowe, J. A. Xhaja, A. Kennedy, R. E. Brown, C. J. Flood, K. L. | J Healthc Qual | 2018 | |
| Screening for delirium with the Intensive Care Delirium Screening Checklist (ICDSC): Symptom profile and utility of individual items in the identification of delirium dependent on the level of sedation. | Boettger, S. Meyer, R. Richter, A. Fernandez, S. F. Rudiger, A. Schubert, M. Jenewein, J. Nunez, D. G. | Palliat Support Care | 2018 |
4th edition |
| The impact of psychomotor subtypes and duration of delirium on 6-month mortality in hip-fractured elderly patients. | Bellelli, G. Carnevali, L. Corsi, M. Morandi, A. Zambon, A. Mazzola, P. Galeazzi, M. Bonfanti, A. Massariello, F. Szabo, H. Oliveri, G. Haas, J. d'Oro, L. C. Annoni, G. | Int J Geriatr Psychiatry | 2018 |
delirium |
| Validation of the Brief Confusion Assessment Method for screening delirium in elderly medical patients in a German emergency department. | Baten, V. Busch, H. J. Busche, C. Schmid, B. Heupel-Reuter, M. Perlov, E. Brich, J. Kloppel, S. | Acad Emerg Med | 2018 |
bCAM |
| Association of intensive care unit delirium with sleep disturbance and functional disability after critical illness: an observational cohort study. | Altman, M. T. Knauert, M. P. Murphy, T. E. Ahasic, A. M. Chauhan, Z. Pisani, M. A. | Ann Intensive Care | 2018 |
Activities of daily living |
| Impact of Delirium on Patients Hospitalized for Myocardial Infarction: a Propensity Score Analysis of The National Inpatient Sample. | Abdullah, A. Eigbire, G. Salama, A. Wahab, A. Awadalla, M. Hoefen, R. Alweis, R. | Clin Cardiol | 2018 |
ICD-9-CM codes |
| The role of geriatrician-hospitalists in the care of older adults: A retrospective cohort study. | Sinvani, L. Carney, M. Kozikowski, A. Smilios, C. Patel, V. Qiu, G. Zhang, M. Babalola, O. Kandov, Y. Rosenberg, D. Wolf-Klein, G. Pekmezaris, R. | Arch Gerontol Geriatr | 2018 |
indwelling catheter |
| Clinical and laboratory characteristics associated with referral of hospitalized elderly to palliative care. | Arcanjo, S. P. Saporetti, L. A. Curiati, J. A. E. Jacob-Filho, W. Avelino-Silva, T. J. | Einstein (Sao Paulo) | 2018 | |
| Intraoperative cerebral oximetry-based management for optimizing perioperative outcomes: a meta-analysis of randomized controlled trials. | Zorrilla-Vaca, A. Healy, R. Grant, M. C. Joshi, B. Rivera-Lara, L. Brown, C. Mirski, M. A. | Canadian Journal of Anesthesia | 2018 |
ISRCTN01707446 |
| Postoperative delirium in total knee and hip arthroplasty patients: a study of perioperative modifiable risk factors. | Weinstein, S. M. Poultsides, L. Baaklini, L. R. Mörwald, E. E. Cozowicz, C. Saleh, J. N. Arrington, M. B. Poeran, J. Zubizarreta, N. Memtsoudis, S. G. | British Journal of Anaesthesia | 2018 |
total hip prosthesis |
| Impact of dexmedetomidine infusion during general anaesthesia on incidence of postoperative delirium in elderly patients after major non-cardiac surgery: study protocol of a randomised, double-blinded and placebo-controlled trial. | Wang, B. J. Li, C. J. Hu, J. Li, H. J. Guo, C. Wang, Z. H. Zhang, Q. C. Mu, D. L. Wang, D. X. | BMJ Open | 2018 |
elderly |
| Can education improve clinical practice concerning delirium in older hospitalised patients? Results of a pre-test post-test study on an educational intervention for nursing staff. | van Velthuijsen, E. L. Zwakhalen, S. M. G. Warnier, R. M. J. Ambergen, T. Mulder, W. J. Verhey, F. R. J. Kempen, Gijm | BMC Med Educ | 2018 |
Delirium |
| Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia. | Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T. | Cochrane Database of Systematic Reviews | 2018 |
chlorpromazine |
| Delirium in the Intensive Care Unit: Incidence, risk factors, and impact on outcome. | Tilouche, N. Hassen, M. F. Ali, H. B. S. Jaoued, O. Gharbi, R. El Atrous, S. | Indian Journal of Critical Care Medicine | 2018 |
endotracheal tube |
| Should This Patient Receive Prophylactic Medication to Prevent Delirium?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. | Tess, A. V. Mattison, M. L. P. Leo, J. R. Reynolds, E. E. | Ann Intern Med | 2018 | |
| Use of the CAM-ICU during daily sedation stops in mechanically ventilated patients as assessed and experienced by intensive care nurses - A mixed-methods study. | Steinseth, E. B. Hoye, S. Hov, R. | Intensive Crit Care Nurs | 2018 |
Assessment |
| Risk factors and outcome of postoperative delirium after transcatheter aortic valve replacement. | Stachon, P. Kaier, K. Zirlik, A. Reinohl, J. Heidt, T. Bothe, W. Hehn, P. Zehender, M. Bode, C. von Zur Muhlen, C. | Clin Res Cardiol | 2018 |
In-hospital mortality |
| Neurological Sequelae and Clinical Outcomes After Lung Transplantation. | Smith, P. J. Stonerock, G. L. Ingle, K. K. Saulino, C. K. Hoffman, B. Wasserman, B. Blumenthal, J. A. Palmer, S. M. Klapper, J. A. Hartwig, M. G. Esposito, V. R. Snyder, L. D. | Transplant Direct | 2018 | |
| Comparison of Ketamine- Versus Nonketamine-Based Sedation on Delirium and Coma in the Intensive Care Unit. | Shurtleff, V. Radosevich, J. J. Patanwala, A. E. | Journal of Intensive Care Medicine | 2018 |
adult |
| Postoperative delirium in elderly patients with critical limb ischemia undergoing major leg amputation: a retrospective study. | Shin, Y. H. Yoon, J. S. Jeon, H. J. Kim, Y. B. Kim, Y. S. Park, J. Y. | Korean J Anesthesiol | 2018 |
Amputation |
| The validity and reliability of the Arabic version of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU): A prospective cohort study | Selim, A. Kandeel, N. Elokl, M. Khater, M. S. Saleh, A. N. Bustami, R. Ely, E. W. | Int J Nurs Stud | 2018 |
Delirium |
| Validation of Caregiver-Centered Delirium Detection Tools: A Systematic Review. | Rosgen, B. Krewulak, K. Demiantschuk, D. Ely, E. W. Davidson, J. E. Stelfox, H. T. Fiest, K. M. | J Am Geriatr Soc | 2018 |
caregiver |
| Study protocol to assess the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units: a cluster-randomised, crossover trial (The ICU Visits Study). | Rosa, R. G. Falavigna, M. Robinson, C. C. da Silva, D. B. Kochhann, R. de Moura, R. M. Santos, M. M. S. Sganzerla, D. Giordani, N. E. Eugenio, C. Ribeiro, T. Cavalcanti, A. B. Bozza, F. Azevedo, L. C. P. Machado, F. R. Salluh, J. I. F. Pellegrini, J. A. S | BMJ Open | 2018 |
critical care |
| Attention, arousal and other rapid bedside screening instruments for delirium in older patients: a systematic review of test accuracy studies. | Quispel-Aggenbach, D. W. P. Holtman, G. A. Zwartjes, Haht Zuidema, S. U. Luijendijk, H. J. | Age & Ageing | 2018 | |
| Use of haloperidol versus atypical antipsychotics and risk of in-hospital death in patients with acute myocardial infarction: Cohort study | Park, Y. Bateman, B. T. Kim, D. H. Hernandez-Diaz, S. Patorno, E. Glynn, R. J. Mogun, H. Huybrechts, K. F. | BMJ | 2018 |
acetylsalicylic acid |
| Postictal delirium and violent behavior in patients with post-neurosurgical epilepsy. | Oueslati, B. Fekih-Romdhane, F. Ridha, R. | World Neurosurg | 2018 |
epilepsy |
| Factor Analysis of Delirium in Elderly, Using the Korean Version of Delirium Rating Scale-Revised-98. | Noh, G. Kwon, I. Lee, M. Ahn, S. H. Kim, J. L. | Psychiatry Investigation | 2018 |
Aged |
| Flexible Versus Restrictive Visiting Policies in ICUs: A Systematic Review and Meta-Analysis. | Nassar Junior, A. P. Besen, Bamp Robinson, C. C. Falavigna, M. Teixeira, C. Rosa, R. G. | Crit Care Med | 2018 | |
| Effectiveness of non-pharmacological strategies for managing delirium in hospitalized postoperative adults: An umbrella review protocol. | McNeil, J. Denis, A. M. Michel, U. Concert, C. M. | JBI Database of Systematic Reviews and Implementation Reports | 2018 |
adult |
| Genome-wide association identifies a novel locus for delirium risk. | McCoy, T. H. Hart, K. Pellegrini, A. Perlis, R. H. | Neurobiology of Aging | 2018 |
adult |
| Risk factors for postoperative delirium in patients undergoing free flap reconstruction for oral cancer. | Makiguchi, T. Yokoo, S. Kurihara, J. | Int J Oral Maxillofac Surg | 2018 |
delirium |
| Risk factors for mortality in elderly patients with hip fractures: a meta-analysis of 18 studies. | Liu, Y. Wang, Z. Xiao, W. | Aging Clin Exp Res | 2018 |
Elderly |
| Inflammatory markers in postoperative delirium (POD) and cognitive dysfunction (POCD): A meta-analysis of observational studies. | Liu, X. Yu, Y. Zhu, S. | PLoS One | 2018 | |
| Systematic review of prediction models for delirium in the older adult inpatient. | Lindroth, H. Bratzke, L. Purvis, S. Brown, R. Coburn, M. Mrkobrada, M. Chan, M. T. V. Davis, D. H. J. Pandharipande, P. Carlsson, C. M. Sanders, R. D. | BMJ Open | 2018 |
delirium |
| Age is the Most Significantly Associated Risk Factor with the Development of Delirium in Patients Hospitalized for More Than Five Days in Surgical Wards: Retrospective Cohort Study. | Kubota K, Suzuki A, Ohde S, Yamada U, Hosaka T, Okuno F, Fujitani I, Koitabashi A, Shimada G, Kishida A | Annals of surgery | 2017 |
nitrogen |
| Reduced ex vivo release of pro-inflammatory cytokines and elevated plasma interleukin-6 are inflammatory signatures of post-stroke delirium. | Kowalska, K. Klimiec, E. Weglarczyk, K. Pera, J. Slowik, A. Siedlar, M. Dziedzic, T. | J Neuroinflammation | 2018 |
Cytokines |
| Parkinson's disease-related non-motor features as risk factors for post-operative delirium in spinal surgery. | Kim, K. H. Kang, S. Y. Shin, D. A. Yi, S. Ha, Y. Kim, K. N. Sohn, Y. H. Lee, P. H. | PLoS One | 2018 | |
| Relationships between markers of neurologic and endothelial injury during critical illness and long-term cognitive impairment and disability. | Hughes, C. G. Patel, M. B. Brummel, N. E. Thompson, J. L. McNeil, J. B. Pandharipande, P. P. Jackson, J. C. Chandrasekhar, R. Ware, L. B. Ely, E. W. Girard, T. D. | Intensive Care Medicine | 2018 |
NCT00392795 |
| Incidence, Risk Factors, and Sequelae of Post-kidney Transplant Delirium. | Haugen, C. E. Mountford, A. Warsame, F. Berkowitz, R. Bae, S. G. Thomas A Brown, C. H. th Brennan, D. C. Neufeld, K. J. Carlson, M. C. Segev, D. L. McAdams-DeMarco, M. | J Am Soc Nephrol | 2018 |
clinical |
| Evaluation of an Intervention With Nurses for Delirium Detection After Cardiac Surgery. | Fraser, V. Cossette, S. Mailhot, T. Brisebois, A. Dubé, V. | Worldviews on evidence-based nursing | 2018 |
adult |
| Delirium clinical motor subtypes: a narrative review of the literature and insights from neurobiology. | FitzGerald JM | Aging & mental health | 2017 |
Screening and diagnosis |
| Are antipsychotics effective for the prevention of postoperative delirium? | Castro, V. Guinguis, R. Carrasco, M. | Medwave | 2018 | |
| Measuring mobility in older hospital patients with cognitive impairment using the de Morton Mobility Index. | Braun, T. Gruneberg, C. Thiel, C. Schulz, R. J. | BMC Geriatr | 2018 |
Dementia |
| Haloperidol for delirium in critically ill patients – protocol for a systematic review. | Barbateskovic, M. Kraus, S. R. Collet, M. O. Mathiesen, O. Jakobsen, J. C. Perner, A. Wetterslev, J. | Acta Anaesthesiol Scand | 2018 |
haloperidol |
| Dexmedetomidine vs morphine and midazolam in the prevention and treatment of delirium after adult cardiac surgery; a randomized, double-blinded clinical trial. | Azeem, T. M. A. Yosif, N. E. Alansary, A. M. Esmat, I. M. Mohamed, A. K. | Saudi J Anaesth | 2018 |
Dexmedetomidine |
| Psychometric properties of the Arabic version of the confusion assessment method for the intensive care unit (CAM-ICU). | Aljuaid, M. H. Deeb, A. M. Dbsawy, M. Alsayegh, D. Alotaibi, M. Arabi, Y. M. | BMC Psychiatry | 2018 |
Arabic |
| Postoperative delirium, learning, and anesthetic neurotoxicity: Some perspectives and directions. | Mutch, W. A. El-Gabalawy, R. M. Graham, M. R. | Frontiers in Neurology | 2018 |
adult |
| Designing a nurse-delivered delirium bundle: What intensive care unit staff, survivors, and their families think? | Bannon, L. McGaughey, J. Clarke, M. McAuley, D. F. Blackwood, B. | Aust Crit Care | 2018 |
Delirium |
| The 2014 updated version of the Confusion Assessment Method for the Intensive Care Unit compared to the 5th version of the Diagnostic and Statistical Manual of Mental Disorders and other current methods used by intensivists. | Chanques, G. Ely, E. W. Garnier, O. Perrigault, F. Eloi, A. Carr, J. Rowan, C. M. Prades, A. de Jong, A. Moritz-Gasser, S. Molinari, N. Jaber, S. | Ann Intensive Care | 2018 |
Critical care |
| Effect of a 24-h extended visiting policy on delirium in critically ill patients. | Westphal, G. A. Moerschberger, M. S. Vollmann, D. D. Inacio, A. C. Machado, M. C. Sperotto, G. Cavalcanti, A. B. Koenig, A. | Intensive Care Medicine | 2018 | |
| Effect of Sedation Regimen on Weaning from Mechanical Ventilation in the Intensive Care Unit. | Nunes, S. L. Forsberg, S. Blomqvist, H. Berggren, L. Sorberg, M. Sarapohja, T. Wickerts, C. J. | Clin Drug Investig | 2018 | |
| Validation of the korean version of the delirium motor subtype scale. | Kim, H. Lee, M. Kwon, I. S. Kim, J. L. | Psychiatry Investigation | 2018 |
aged |
| e-Screening revolution: A novel approach to developing a delirium screening tool in the intensive care unit. | Eeles, E. Gunn, H. Sutt, A. L. Pinsker, D. Flaws, D. Jarrett, P. Lye, I. Fraser, J. F. | Australasian Journal on Ageing | 2018 |
delirium |
| Sedation Intensity in the First 48 Hours of Mechanical Ventilation and 180-Day Mortality: A Multinational Prospective Longitudinal Cohort Study. | Shehabi, Y. Bellomo, R. Kadiman, S. Ti, L. K. Howe, B. Reade, M. C. Khoo, T. M. Alias, A. Wong, Y. L. Mukhopadhyay, A. McArthur, C. Seppelt, I. Webb, S. A. Green, M. Bailey, M. J. | Crit Care Med | 2018 | |
| Screening for delirium with the Intensive Care Delirium Screening Checklist (ICDSC): a re-evaluation of the threshold for delirium. | Boettger, S. Garcia Nunez, D. Meyer, R. Richter, A. Rudiger, A. Schubert, M. Jenewein, J. | Swiss Medical Weekly | 2018 | |
| Risk Factors of Postoperative Delirium in the Intensive Care Unit After Liver Transplantation. | Lee, H. Oh, S. Y. Yu, J. H. Kim, J. Yoon, S. Ryu, H. G. | World J Surg | 2018 | |
| Risk Factors for Postoperative Delirium After Deep Brain Stimulation Surgery for Parkinson's Disease. | Tanaka, M. Tani, N. Maruo, T. Oshino, S. Hosomi, K. Saitoh, Y. Kishima, H. | World Neurosurg | 2018 |
Deep Brain Stimulation |
| The relationship of delirium and risk factors in cardiology intensive care unit patients with the nursing workload. | Ozturk Birge, A. Beduk, T. | J Clin Nurs | 2018 |
Critical Care |
| Protocol for a single-centre prospective observational study of postoperative delirium following total joint arthroplasties among South East Asians. | Abdullah, H. R. Tan, S. R. Lee, S. J. Bin Abd Razak, H. R. Seet, R. H. Ying, H. Sethi, E. Sim, E. Y. | BMJ Open | 2018 |
*delirium |
| Preoperative statins are associated with a reduced risk of postoperative delirium following vascular surgery. | Lee, D. S. Lee, M. Y. Park, C. M. Kim, D. I. Kim, Y. W. Park, Y. J. | PLoS One | 2018 | |
| Predisposing and precipitating factors for delirium in community-dwelling older adults admitted to hospital with this condition: A prospective case series. | Magny, E. Le Petitcorps, H. Pociumban, M. Bouksani-Kacher, Z. Pautas, É Belmin, J. Bastuji-Garin, S. Lafuente-Lafuente, C. | PLoS One | 2018 |
aged |
| Predicting excess cost for older inpatients with clinical complexity: A retrospective cohort study examining cognition, comorbidities and complications | Bail, K. Draper, B. Berry, H. Karmel, R. Goss, J. | PLoS One | 2018 |
adult |
| Pilot Study of a Two-Step Delirium Detection Protocol Administered By Certified Nursing Assistants, Physicians, and Registered Nurses. | Fick, D. M. Inouye, S. K. McDermott, C. Zhou, W. Ngo, L. Gallagher, J. McDowell, J. Penrod, J. Siuta, J. Covaleski, T. Marcantonio, E. R. | J Gerontol Nurs | 2018 |