What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Partial and no recovery from delirium after hospital discharge predict increased adverse events. | Cole MG, McCusker J, Bailey R, Bonnycastle M, Fung S, Ciampi A, Belzile E | Age and ageing | 2016 |
aged |
| Development and validation of risk-stratification delirium prediction model for critically ill patients: A prospective, observational, single-center study. | Chen, Y. Du, H. Wei, B. H. Chang, X. N. Dong, C. M. | Medicine | 2017 |
Apache |
| The quality of life of patients developed delirium after coronary artery bypass grafting is determined by cognitive function after discharge: A cross-sectional study. | Chen, Y. Ding, S. Tao, X. Feng, X. Lu, S. Shen, Y. Wu, Y. An, X. | Int J Nurs Pract | 2017 |
cognitive function |
| Prevalence and risk factors for postoperative delirium in total joint arthroplasty patients: A prospective study. | Chen, Wenliang Ke, Xiurong Wang, Xiaoqing Sun, Xiaoliang Wang, Juncheng Yang, Guojing Xia, Haijie Zhang, Lei | General Hospital Psychiatry | 2017 |
Delirium |
| Delirium post-stroke: short- to long-term effect on anxiety and depression compared to effect on cognition. | Chan, E. K. W. Shen, Q. Cordato, D. Kneebone, I. Xu, Y. H. Chan, D. K. Y. | Top Stroke Rehabil | 2017 |
Anxiety |
| Independent Predictors of the Duration and Overall Burden of Postoperative Delirium After Cardiac Surgery in Adults: An Observational Cohort Study. | Cereghetti, C. Siegemund, M. Schaedelin, S. Fassl, J. Seeberger, M. D. Eckstein, F. S. Steiner, L. A. Goettel, N. | Journal of Cardiothoracic and Vascular Anesthesia | 2017 |
adult |
| State of the Art and Promise of Structural Neuroimaging in Postoperative Delirium and Postoperative Cognitive Decline. | Cavallari, M. Guttmann, C. R. G. Inouye, S. K. Alsop, D. C. | Am J Geriatr Psychiatry | 2017 | |
| Longitudinal diffusion changes following postoperative delirium in older people without dementia. | Cavallari, M. Dai, W. Guttmann, C. R. G. Meier, D. S. Ngo, L. H. Hshieh, T. T. Fong, T. G. Schmitt, E. Press, D. Z. Travison, T. G. Marcantonio, E. R. Jones, R. N. Inouye, S. K. Alsop, D. C. | Neurology | 2017 |
Aged |
| Cerebrospinal Fluid Apolipoprotein E Levels in Delirium. | Caplan, G. A. Tai, J. Mohd Hanizan, F. McVeigh, C. L. Hill, M. A. Poljak, A. | Dement Geriatr Cogn Dis Extra | 2017 |
Aged, 80 years and over |
| Don't call me crazy! Delirium occurs outside of the ICU. | Cahill, A. Pearcy, C. Almahmoud, K. Agrawal, V. Mani, U. Sladek, P. Truitt, M. S. | J Trauma Acute Care Surg | 2017 | |
| Delirium in the ICU: What About the Floor? | Cahill, A. Pearcy, C. Agrawal, V. Sladek, P. Truitt, M. S. | J Trauma Nurs | 2017 | |
| Delirium and exposure to psychoactive medications in critically ill adults: A multi-centre observational study. | Burry, L. D. Williamson, D. R. Mehta, S. Perreault, M. M. Mantas, I. Mallick, R. Fergusson, D. A. Smith, O. Fan, E. Dupuis, S. Herridge, M. Rose, L. | J Crit Care | 2017 |
Anticholinergic |
| Effect of delirium motoric subtypes on administrative documentation of delirium in the surgical intensive care unit. | Bui LN, Pham VP, Shirkey BA, Swan JT | Journal of clinical monitoring and computing | 2017 |
Cam-icu |
| Delirium in a residential care facility: An exploratory study of staff knowledge. | Buettel, A. Cleary, M. Bramble, M. | Australasian Journal on Ageing | 2017 |
carers |
| Frailty and Subsequent Disability and Mortality among Patients with Critical Illness. | Brummel, Nathan E. Bell, Susan P. Girard, Timothy D. Pandharipande, Pratik P. Jackson, James C. Morandi, Alessandro Thompson, Jennifer L. Chandrasekhar, Rameela Bernard, Gordon R. Dittus, Robert S. Gill, Thomas M. Ely, E. Wesley | American Journal of Respiratory & Critical Care Medicine | 2017 | |
| Postoperative delirium after pharyngolaryngectomy with esophagectomy: a role for ramelteon and suvorexant. | Booka, E. Tsubosa, Y. Matsumoto, T. Takeuchi, M. Kitani, T. Nagaoka, M. Imai, A. Kamijo, T. Iida, Y. Shimada, A. Takebayashi, K. Niihara, M. Mori, K. Onitsuka, T. Takeuchi, H. Kitagawa, Y. | Esophagus | 2017 |
anxiolytic agent |
| Pipamperone and delirium: A preliminary evaluation of its effectiveness in the management of delirium and its subtypes. | Boettger, S. Knoepfel, S. Schubert, M. Garcia Nuñez, D. Plichta, M. M. Klaghofer, R. Jenewein, J. | Swiss Medical Weekly | 2017 |
haloperidol |
| Brief assessment of delirium subtypes: Psychometric evaluation of the Delirium Motor Subtype Scale (DMSS)-4 in the intensive care setting. | Boettger, Soenke Garcia NuÑEz, David Meyer, Rafael Richter, Andre Schubert, Maria Meagher, David Jenewein, Josef Nuñez, David Garcia | Palliative & Supportive Care | 2017 | |
| Postoperative Delirium as a Target for Surgical Quality Improvement. | Berian, J. R. Zhou, L. Russell, M. M. Hornor, M. A. Cohen, M. E. Finlayson, E. Ko, C. Y. Rosenthal, R. A. Robinson, T. N. | Ann Surg | 2017 | |
| The association between delirium and sarcopenia in older adult patients admitted to acute geriatrics units: Results from the GLISTEN multicenter observational study. | Bellelli, G. Zambon, A. Volpato, S. Abete, P. Bianchi, L. Bo, M. Cherubini, A. Corica, F. Di Bari, M. Maggio, M. Manca, G. M. Rizzo, M. R. Rossi, A. Landi, F. | Clin Nutr | 2017 |
Body mass index |
| Distinct Cognitive Trajectories in the First Year After Hip Fracture. | Beishuizen, S. J. E. van Munster, B. C. de Jonghe, A. Abu-Hanna, A. Buurman, B. M. de Rooij, S. E. | Journal of the American Geriatrics Society | 2017 |
aged |
| A quality improvement approach to cognitive assessment on hospice admission: could we use the 4AT or Short CAM? | Baird, L. Spiller, J. A. | BMJ Open Qual | 2017 |
Pdsa |
| Incidence of Postoperative Delirium and Its Impact on Outcomes After Transcatheter Aortic Valve Implantation. | Bagienski, M. Kleczynski, P. Dziewierz, A. Rzeszutko, L. Sorysz, D. Trebacz, J. Sobczynski, R. Tomala, M. Stapor, M. Dudek, D. | Am J Cardiol | 2017 |
Aged |
| Rates of Delirium Diagnosis Do Not Improve with Emergency Risk Screening: Results of the Emergency Department Delirium Initiative Trial. | Arendts, G. Love, J. Nagree, Y. Bruce, D. Hare, M. Dey, I. | J Am Geriatr Soc | 2017 |
Aged |
| A Comparison of the Severe Cognitive Impairment Rating Scale With the Mini-Mental State Examination and Delirium Rating Scale-Revised-98 for Delirium: A Cross-sectional Study. | Ahn, S. H. Choi, J. H. Im, C. S. Kim, T. S. Kim, J. L. | Psychosomatics | 2017 |
cognitive impairment |
| Motor Disturbances in Elderly Medical Inpatients and Their Relationship to Delirium. | Adamis, D. McCarthy, G. O'Mahony, E. Meagher, D. | J Geriatr Psychiatry Neurol | 2017 |
cognition |
| Predicting delirium: are we there yet? | Evered LA | British journal of anaesthesia | 2017 | |
| Low brain tissue oxygenation contributes to the development of delirium in critically ill patients: A prospective observational study. | , , Wood MD, Maslove DM, Muscedere JG, Day AG, Gordon Boyd J | Journal of critical care | 2017 | |
| Nurse awareness of patients who may have incident delirium. | Sander R | Nursing older people | 2017 | |
| Implementing Nurse-Facilitated Person-Centered Care Approaches for Patients With Delirium Superimposed on Dementia in the Acute Care Setting. | Yevchak A, Fick DM, Kolanowski AM, McDowell J, Monroe T, LeViere A, Mion L | Journal of gerontological nursing | 2017 | |
| Postoperative delirium in total joint arthroplasty patients. | Mahawer B, Suthar N | General hospital psychiatry | 2017 | |
| Impact of frailty and residual subsyndromal delirium on 1-year functional recovery: A prospective cohort study. | Chew J, Lim WS, Chong MS, Ding YY, Tay L | Geriatrics & gerontology international | 2017 | |
| Placebo might be superior to antipsychotics in management of delirium in the palliative care setting. | Boettger S, Jenewein J | Evidence-based medicine | 2017 | |
| One-year mortality after hip fracture in older individuals: the effects of delirium and dementia. | Mitchell R, Harvey L, Brodaty H, Draper B, Close J | Archives of gerontology and geriatrics | 2017 | |
| Postoperative Delirium in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting According to the Anesthetic Agent: A Retrospective Study. | Oh CS, Park S, Wan Hong S, Kang WS, Yoon TG, Kim SH | Journal of cardiothoracic and vascular anesthesia | 2017 | |
| Statin and Its Association With Delirium in the Medical ICU. | Mather JF, Corradi JP, Waszynski C, Noyes A, Duan Y, Grady J, Dicks R | Critical care medicine | 2017 | |
| The problem of delirium following transcatheter aortic valve replacement. | Orvin K, Kornowski R | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions | 2017 | |
| The intensive care delirium research agenda: a multinational, interprofessional perspective. | Pandharipande PP, Ely EW, Arora RC, Balas MC, Boustani MA, La Calle GH, Cunningham C, Devlin JW, Elefante J, Han JH, MacLullich AM, Maldonado JR, Morandi A, Needham DM, Page VJ, Rose L, Salluh JIF, Sharshar T, Shehabi Y, Skrobik Y, Slooter AJC, Smith HAB | Intensive care medicine | 2017 | |
| Delirium prevention in critically ill adults through an automated reorientation intervention - A pilot randomized controlled trial. | Munro CL, Cairns P, Ji M, Calero K, Anderson WM, Liang Z | Heart & lung : the journal of critical care | 2017 | |
| Anticholinergic drug exposure is associated with delirium and postdischarge institutionalization in acutely ill hospitalized older patients. | Egberts A, van der Craats ST, van Wijk MD, Alkilabe S, van den Bemt PMLA, Mattace-Raso FUS | Pharmacology research & perspectives | 2017 | |
| Acute Brain Failure: Pathophysiology, Diagnosis, Management, and Sequelae of Delirium. | Maldonado JR | Critical care clinics | 2017 | |
| A retrospective analysis of the effectiveness of antipsychotics in the treatment of ICU delirium. | Weaver CB, Kane-Gill SL, Gunn SR, Kirisci L, Smithburger PL | Journal of critical care | 2017 | |
| Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery: A Randomized Clinical Trial. | Deiner S, Luo X, Lin HM, Sessler DI, Saager L, Sieber FE, Lee HB, Sano M, , Jankowski C, Bergese SD, Candiotti K, Flaherty JH, Arora H, Shander A, Rock P | JAMA surgery | 2017 | |
| Confusion Regarding Surgical Delirium-Is Dexmedetomidine the Answer? | Berian JR, Rosenthal RA, Robinson TN | JAMA surgery | 2017 | |
| Yokukansan for the treatment of preoperative anxiety and postoperative delirium in colorectal cancer patients: a retrospective study. | Wada S, Inoguchi H, Hirayama T, Matsuoka YJ, Uchitomi Y, Ochiai H, Tsukamoto S, Shida D, Kanemitsu Y, Shimizu K | Japanese journal of clinical oncology | 2017 | |
| Delirium screening in intensive care: A life saving opportunity. | Lamond E, Murray S, Gibson CE | Intensive & critical care nursing | 2017 | |
| Methodologic considerations in the design and analysis of nested case-control studies: association between cytokines and postoperative delirium. | Ngo LH, Inouye SK, Jones RN, Travison TG, Libermann TA, Dillon ST, Kuchel GA, Vasunilashorn SM, Alsop DC, Marcantonio ER | BMC medical research methodology | 2017 | |
| Risk factors for postoperative delirium in patients undergoing vascular surgery. | Galyfos GC, Geropapas GE, Sianou A, Sigala F, Filis K | Journal of vascular surgery | 2017 | |
| Clinical Features Associated with Delirium Motor Subtypes in Older Inpatients: Results of a Multicenter Study. | Morandi A, Di Santo SG, Cherubini A, Mossello E, Meagher D, Mazzone A, Bianchetti A, Ferrara N, Ferrari A, Musicco M, Trabucchi M, Bellelli G, | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2017 | |
| Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial. | Avidan MS, Maybrier HR, Abdallah AB, Jacobsohn E, Vlisides PE, Pryor KO, Veselis RA, Grocott HP, Emmert DA, Rogers EM, Downey RJ, Yulico H, Noh GJ, Lee YH, Waszynski CM, Arya VK, Pagel PS, Hudetz JA, Muench MR, Fritz BA, Waberski W, Inouye SK, Mashour GA, | Lancet (London, England) | 2017 | |
| Ketamine fails to prevent postoperative delirium. | Eisenach JC | Lancet (London, England) | 2017 | |
| Association of White Matter Lesions, Cerebral Atrophy, Intracranial Extravascular Calcifications, and Ventricular-Communicating Hydrocephalus with Delirium Among Veterans. | Detweiler MB, Sherigar RM, Bader G, Sullivan K, Kenneth A, Kalafat N, Reddy P, Lutgens B | Southern medical journal | 2017 |
Aged, Atrophy, diagnostic imaging, Brain Diseases, complications, Calcinosis, complications, Case-Control Studies, Cerebellum, diagnostic imaging, Delirium, etiology, Female, Humans, Hydrocephalus, complications, Male, Middle Aged, Parietal Lobe, diagnostic imaging, Retrospective Studies, Tomography, X-Ray Computed, Veterans, White Matter, pathology |
| The role of predictive coding in the pathogenesis of delirium. | FitzGerald JM | Medical hypotheses | 2017 | |
| Detecting delirium superimposed on dementia: diagnostic accuracy of a simple combined arousal and attention testing procedure. | Richardson SJ, Davis DHJ, Bellelli G, Hasemann W, Meagher D, Kreisel SH, MacLullich AMJ, Cerejeira J, Morandi A | International psychogeriatrics | 2017 | |
| Acetylcholinesterase and butyrylcholinesterase in cardiosurgical patients with postoperative delirium. | John M, Ely EW, Halfkann D, Schoen J, Sedemund-Adib B, Klotz S, Radtke F, Stehr S, Hueppe M | Journal of intensive care | 2017 | |
| Performance of the modified Richmond Agitation Sedation Scale in identifying delirium in older emergency department patients. | Grossmann FF, Hasemann W, Kressig RW, Bingisser R, Nickel CH | The American journal of emergency medicine | 2017 | |
| Hypoactive delirium. | Hosker C, Ward D | BMJ (Clinical research ed.) | 2017 | |
| Parecoxib Supplementation to Morphine Analgesia Decreases Incidence of Delirium in Elderly Patients After Hip or Knee Replacement Surgery: A Randomized Controlled Trial. | Mu DL, Zhang DZ, Wang DX, Wang G, Li CJ, Meng ZT, Li YW, Liu C, Li XY | Anesthesia and analgesia | 2017 | |
| Identifying delirium in older adults with pre-existing mental illness. | Bennett C | The Nurse practitioner | 2017 | |
| Iatrogenic Withdrawal Syndrome or Undiagnosed Delirium? | Traube C, Silver G | Critical care medicine | 2017 | |
| The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial. | Tanaka P, Goodman S, Sommer BR, Maloney W, Huddleston J, Lemmens HJ | Journal of clinical anesthesia | 2017 | |
| Incidence of delirium in postoperative patients treated with total knee and hip arthroplasty. | Bosmak FS, Gibim PT, Guimarães S, Ammirati AL | Revista da Associacao Medica Brasileira (1992) | 2017 | |
| Implementation of an ICU Bundle: An Interprofessional Quality Improvement Project to Enhance Delirium Management and Monitor Delirium Prevalence in a Single PICU. | Simone S, Edwards S, Lardieri A, Walker LK, Graciano AL, Kishk OA, Custer JW | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies | 2017 | |
| Risk factors for postoperative delirium in patients undergoing major head and neck cancer surgery: a meta-analysis. | Zhu Y, Wang G, Liu S, Zhou S, Lian Y, Zhang C, Yang W | Japanese journal of clinical oncology | 2017 | |
| A family intervention to reduce delirium in hospitalised ICU patients: A feasibility randomised controlled trial. | Mitchell ML, Kean S, Rattray JE, Hull AM, Davis C, Murfield JE, Aitken LM | Intensive & critical care nursing | 2017 | |
| Advancing the Neurophysiological Understanding of Delirium. | Shafi MM, Santarnecchi E, Fong TG, Jones RN, Marcantonio ER, Pascual-Leone A, Inouye SK | Journal of the American Geriatrics Society | 2017 | |
| CHERISH (collaboration for hospitalised elders reducing the impact of stays in hospital): protocol for a multi-site improvement program to reduce geriatric syndromes in older inpatients. | Mudge AM, Banks MD, Barnett AG, Blackberry I, Graves N, Green T, Harvey G, Hubbard RE, Inouye SK, Kurrle S, Lim K, McRae P, Peel NM, Suna J, Young AM | BMC geriatrics | 2017 |
Accidental Falls, prevention & control, Aged, Aged, 80 and over, Cooperative Behavior, Cost-Benefit Analysis, methods, Delirium, prevention & control, Feeding Behavior, physiology, Female, Hospitalization, trends, Humans, Inpatients, psychology, Length of Stay, trends, Male, Nutritional Status, physiology, Patient Discharge, trends, Pilot Projects, Quality of Life, psychology, Research Design, Syndrome, Walking, physiology |
| Design considerations of a randomized controlled trial of sedation level during hip fracture repair surgery: a strategy to reduce the incidence of postoperative delirium in elderly patients. | Li T, Wieland LS, Oh E, Neufeld KJ, Wang NY, Dickersin K, Sieber FE | Clinical trials (London, England) | 2017 | |
| Acute Kidney Injury as a Risk Factor for Delirium and Coma during Critical Illness. | Siew ED, Fissell WH, Tripp CM, Blume JD, Wilson MD, Clark AJ, Vincz AJ, Ely EW, Pandharipande PP, Girard TD | American journal of respiratory and critical care medicine | 2017 | |
| Screening for postoperative delirium in patients with acute hip fracture: Assessment of predictive factors. | Koskderelioglu A, Onder O, Gucuyener M, Altay T, Kayali C, Gedizlioglu M | Geriatrics & gerontology international | 2017 | |
| Blood transfusion strategy and risk of postoperative delirium in nursing homes residents with hip fracture. A post hoc analysis based on the TRIFE randomized controlled trial. | Blandfort S, Gregersen M, Borris LC, Damsgaard EM | Aging clinical and experimental research | 2017 | |
| Delirium risk stratification in consecutive unselected admissions to acute medicine: validation of a susceptibility score based on factors identified externally in pooled data for use at entry to the acute care pathway. | Pendlebury ST, Lovett NG, Smith SC, Wharton R, Rothwell PM | Age and ageing | 2017 | |
| Pain, Agitation, and Delirium Guidelines: Interprofessional Perspectives to Translate the Evidence. | Jablonski J, Gray J, Miano T, Redline G, Teufel H, Collins T, Pascual-Lopez J, Sylvia M, Martin ND | Dimensions of critical care nursing : DCCN | 2017 | |
| Delirium in the acute phase after stroke: comparison between methods of detection. | Infante MT, Pardini M, Balestrino M, Finocchi C, Malfatto L, Bellelli G, Mancardi GL, Gandolfo C, Serrati C | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology | 2017 | |
| Trials of statins in delirium-stymied by complex methods? | Skrobik, Y. Devlin, J. | Lancet Respir med | 2017 | |
| An integrative literature review exploring the clinical management of delirium in patients with advanced cancer | Lawley, H. Hewison, A. | J Clin Nurs | 2017 |
advanced cancer |
| Comparison of propofol and dexmedetomidine infused overnight to treat hyperactive and mixed ICU delirium: a protocol for the Basel ProDex clinical trial. | Hollinger, A. Ledergerber, K. von Felten, S. Sutter, R. Ruegg, S. Gantner, L. Zimmermann, S. Blum, A. Steiner, L. A. Marsch, S. Siegemund, M. | BMJ Open | 2017 |
Dexmedetomidine |
| Protocol for an observational study of delirium in the post-anaesthesia care unit (PACU) as a potential predictor of subsequent postoperative delirium. | Cui, V. Tedeschi, C. M. Kronzer, V. L. McKinnon, S. L. Avidan, M. S. | BMJ Open | 2017 |
adult intensive & critical care |
| Debate article: Antipsychotic medications are clinically useful for the treatment of delirium. | Meagher, D. Agar, M. R. Teodorczuk, A. | Int J Geriatr Psychiatry | 2017 |
antipsychotics |
| A Novel Stress-Diathesis Model to Predict Risk of Post-operative Delirium: Implications for Intra-operative Management. | El-Gabalawy, R. Patel, R. Kilborn, K. Blaney, C. Hoban, C. Ryner, L. Funk, D. Legaspi, R. Fisher, J. A. Duffin, J. Mikulis, D. J. Mutch, W. A. C. | Front Aging Neurosci | 2017 |
neuroimaging |
| Treatment of asymptomatic UTI in older delirious medical in-patients: A prospective cohort study. | Dasgupta, M. Brymer, C. Elsayed, S. | Arch Gerontol Geriatr | 2017 |
Aged |
| Early geriatric consultation increases adherence to TQIP Geriatric Trauma Management Guidelines. | Southerland, L. T. Gure, T. R. Ruter, D. I. Li, M. M. Evans, D. C. | J Surg Res | 2017 |
Aged |
| Post-Intensive Care Unit Psychiatric Comorbidity and Quality of Life. | Wang, S. Mosher, C. Perkins, A. J. Gao, S. Lasiter, S. Khan, S. Boustani, M. Khan, B. | Journal of Hospital Medicine | 2017 | |
| Potentially modifiable factors contributing to sepsis-associated encephalopathy. | Sonneville, Romain Montmollin, Etienne Poujade, Julien Garrouste-Orgeas, Maïté Souweine, Bertrand Darmon, Michael Mariotte, Eric Argaud, Laurent Barbier, François Goldgran-Toledano, Dany Marcotte, Guillaume Dumenil, Anne-Sylvie Jamali, Samir Lacave, Gu | Intensive Care Medicine | 2017 | |
| Comprehensive Geriatric Assessment for Prevention of Delirium After Hip Fracture: A Systematic Review of Randomized Controlled Trials. | Shields L, Henderson V, Caslake R | Journal of the American Geriatrics Society | 2017 |
Aged |
| Age- and gender-related peculiarities of patients with delirium in the cardiac intensive care unit. | Serpytis, P. Navickas, P. Navickas, A. Serpytis, R. Navickas, G. Glaveckaite, S. | Kardiol Pol | 2017 |
age |
| Delirium Frequency and Risk Factors Among Patients With Cancer in Palliative Care Unit. | Şenel G, Uysal N, Oguz G, Kaya M, Kadioullari N, Koçak N, Karaca S | The American journal of hospice & palliative care | 2017 |
adult |
| Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study. | Scholtens, R. M. van Munster, B. C. van Faassen, M. van Kempen, M. F. Kema, I. P. de Rooij, S. E. | Mech Ageing Dev | 2017 |
Aged |
| Association between delirium and cognitive change after cardiac surgery. | Sauer, A. C. Veldhuijzen, D. S. Ottens, T. H. Slooter, A. J. C. Kalkman, C. J. van Dijk, D. | Br J Anaesth | 2017 |
cardiac surgical procedures |
| Effectiveness and Safety of an Extended ICU Visitation Model for Delirium Prevention: A Before and After Study. | Rosa, R. G. Tonietto, T. F. da Silva, D. B. Gutierres, F. A. Ascoli, A. M. Madeira, L. C. Rutzen, W. Falavigna, M. Robinson, C. C. Salluh, J. I. Cavalcanti, A. B. Azevedo, L. C. Cremonese, R. V. Haack, T. R. Eugenio, C. S. Dornelles, A. Bessel, M. Teles, | Crit Care Med | 2017 |
Aged |
| Association of postoperative delirium with markers of neurodegeneration and brain amyloidosis: a pilot study. | Rolandi, E. Cavedo, E. Pievani, M. Galluzzi, S. Ribaldi, F. Buckley, C. Cunningham, C. Guerra, U. P. Musarra, M. Morzenti, S. Magnaldi, S. Patassini, M. Terragnoli, F. Matascioli, L. Franzoni, S. Annoni, G. Carnevali, L. Bellelli, G. Frisoni, G. B. | Neurobiol Aging | 2017 |
Alzheimer’s disease |
| Misidentification of mental health symptoms in presence of organic diseases and delirium during psychiatric liaison consulting. | Otani, V. H. O. Otani, Tzds Freirias, A. Calfat, E. L. B. Aoki, P. S. Cordeiro, Q. Junior Kanaan, R. A. A. Cross, S. Liersch-Sumskis, S. Uchida, R. R. | Int J Psychiatry Clin Pract | 2017 |
Diagnostic errors |
| A randomised trial of peri-operative positive airway pressure for postoperative delirium in patients at risk for obstructive sleep apnoea after regional anaesthesia with sedation or general anaesthesia for joint arthroplasty. | Nadler, J. W. Evans, J. L. Fang, E. Preud'Homme, X. A. Daughtry, R. L. Chapman, J. B. Bolognesi, M. P. Attarian, D. E. Wellman, S. S. Krystal, A. D. | Anaesthesia | 2017 |
clinical trial |
| Using anchors from free text in electronic health records to diagnose postoperative delirium. | Mikalsen, K. Ø Soguero-Ruiz, C. Jensen, K. Hindberg, K. Gran, M. Revhaug, A. Lindsetmo, R. O. Skrøvseth, S. O. Godtliebsen, F. Jenssen, R. | Computer Methods and Programs in Biomedicine | 2017 |
haloperidol |
| Postinjection delirium/sedation syndrome in patients with schizophrenia receiving olanzapine long-acting injection: results from a large observational study. | Meyers, K. J. Upadhyaya, H. P. Landry, J. L. Chhabra-Khanna, R. Falk, D. M. Seetharama Rao, B. Jones, M. E. | BJ Psych Open | 2017 | |
| Risk Factors for Delirium in Older Medical Inpatients in Tanzania. | Lewis, E. G. Banks, J. Paddick, S. M. Duinmaijer, A. Tucker, L. Kisoli, A. Cletus, J. Lissu, C. Kilonzo, K. Cosker, G. Mukaetova-Ladinska, E. B. Dotchin, C. Gray, W. Walker, R. Urasa, S. | Dement Geriatr Cogn Disord | 2017 |
Delirium |
| The experience of intensive care nurses caring for patients with delirium: A phenomenological study. | LeBlanc, A. Bourbonnais, F. F. Harrison, D. Tousignant, K. | Intensive Crit Care Nurs | 2017 |
Critical care |
| Pre-stroke apathy symptoms are associated with an increased risk of delirium in stroke patients | Klimiec, E. Kowalska, K. Pasinska, P. Klimkowicz-Mrowiec, A. Szyper, A. Pera, J. Slowik, A. Dziedzic, T. | Sci Rep | 2017 | |
| Current practice and opinions of hospital pharmacists regarding their role in the screening, prevention and treatment of delirium. | Kassie, G. M. Kalisch Ellett, L. M. Nguyen, T. A. Roughead, E. E. | Int J Clin Pharm | 2017 |
Australia |
| An educational programme to improve acute care nurses' knowledge, attitudes and family caregiver involvement in care of people with cognitive impairment. | Kang, Y. Moyle, W. Cooke, M. O'Dwyer, S. T. | Scand J Caring Sci | 2017 |
carers |