What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Surgical procedure and postoperative delirium in geriatric hip fracture patients. | Kavouspour C, Wang N, Mears SC, Oh ES, Sieber FE | European journal of anaesthesiology | 2016 | |
| The effect of range of motion exercises on delirium prevention among patients aged 65 and over in intensive care units. | Karadas C, Ozdemir L | Geriatric nursing (New York, N.Y.) | 2016 | |
| Managing verbal agitation in people with dementia and delirium. | Inkley F, Goldberg S | Nursing older people | 2016 | |
| The Fog of War: Delirium Prevalence in a Combat Intensive Care Unit. | Ingalls NK, Armstrong B, Hester M, Hatzfeld JJ, Robinson BR, Fortuna GR | Military medicine | 2016 | |
| General versus spinal anaesthesia and postoperative delirium in an orthogeriatric population. | Ilango S, Pulle RC, Bell J, Kuys SS | Australasian journal on ageing | 2016 | |
| Measuring delirium point-prevalence in two Australian palliative care inpatient units. | Hosie A, Lobb E, Agar M, Davidson P, Chye R, Lam L, Phillips J | International journal of palliative nursing | 2016 |
Aged, Aged, 80 and over, Australia, epidemiology, Cross-Sectional Studies, Delirium, diagnosis, Female, Humans, Inpatients, statistics & numerical data, Male, Mass Screening, statistics & numerical data, Middle Aged, Palliative Care, statistics & numerical data, Prevalence, Prospective Studies |
| The Relationship Between Sleep-Wake Cycle Disturbance and Trajectory of Cognitive Recovery During Acute Traumatic Brain Injury. | Holcomb EM, Towns S, Kamper JE, Barnett SD, Sherer M, Evans C, Nakase-Richardson R | The Journal of head trauma rehabilitation | 2016 | |
| Effectiveness of the STOPP/START (Screening Tool of Older Persons' potentially inappropriate Prescriptions/Screening Tool to Alert doctors to the Right Treatment) criteria: systematic review and meta-analysis of randomized controlled studies. | Hill-Taylor B, Walsh KA, Stewart S, Hayden J, Byrne S, Sketris IS | Journal of clinical pharmacy and therapeutics | 2016 | |
| Impact of multicomponent, nonpharmacologic interventions on perioperative cortisol and melatonin levels and postoperative delirium in elderly oral cancer patients. | Guo Y, Sun L, Li L, Jia P, Zhang J, Jiang H, Jiang W | Archives of gerontology and geriatrics | 2016 |
Aged, Delirium, diagnosis, Female, Humans, Hydrocortisone, urine, Intensive Care Units, Male, Melatonin, urine, Middle Aged, Mouth Neoplasms, surgery, Postoperative Care, Postoperative Complications, prevention & control, Preoperative Care, Preoperative Period, Psychomotor Agitation, prevention & control, Sleep, drug effects, Treatment Outcome |
| Prevalence and risk factors of postoperative delirium in elderly hip fracture patients. | Guo Y, Jia P, Zhang J, Wang X, Jiang H, Jiang W | The Journal of international medical research | 2016 | |
| Prevalence of delirium among patients at a cancer ward: Clinical risk factors and prediction by bedside cognitive tests. | Grandahl MG, Nielsen SE, Koerner EA, Schultz HH, Arnfred SM | Nordic journal of psychiatry | 2016 | |
| Validation of the delirium observation screening scale in a hospitalized older population. | Gavinski K, Carnahan R, Weckmann M | Journal of hospital medicine | 2016 | |
| Delirium recall - an integrative review. | Fuller V | Journal of clinical nursing | 2016 | |
| Concordance between the delirium motor subtyping scale (DMSS) and the abbreviated version (DMSS-4) over longitudinal assessment in elderly medical inpatients. | Fitzgerald J, O'Regan N, Adamis D, Timmons S, Dunne C, Trzepacz P, Meagher D | International psychogeriatrics / IPA | 2016 | |
| Obesity and post-operative cognitive dysfunction: a systematic review and meta-analysis. | Feinkohl I, Winterer G, Pischon T | Diabetes/metabolism research and reviews | 2016 | |
| Antipsychotic-induced akathisia in delirium: A systematic review. | Espi Forcen F, Matsoukas K, Alici Y | Palliative & supportive care | 2016 | |
| Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial. | Djaiani G, Silverton N, Fedorko L, Carroll J, Styra R, Rao V, Katznelson R | Anesthesiology | 2016 | |
| An Innovative Approach to Improving the Accuracy of Delirium Assessments Using the Confusion Assessment Method for the Intensive Care Unit. | DiLibero J, O'Donoghue SC, DeSanto-Madeya S, Felix J, Ninobla A, Woods A | Dimensions of critical care nursing : DCCN | 2016 | |
| Moderate dose melatonin for the abatement and treatment of delirium in elderly general medical inpatients: study protocol of a placebo controlled, randomised, double blind trial. | Clayton-Chubb DI, Lange PW | BMC geriatrics | 2016 | |
| Underdiagnosis of delirium on admission and prediction of patients who will develop delirium during their inpatient stay: a pilot study. | Chin YC, Koh GC, Tay YK, Tan CH, Merchant RA | Singapore medical journal | 2016 | |
| Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI. | Cavallari M, Dai W, Guttmann CR, Meier DS, Ngo LH, Hshieh TT, Callahan AE, Fong TG, Schmitt E, Dickerson BC, Press DZ, Marcantonio ER, Jones RN, Inouye SK, Alsop DC, | Brain : a journal of neurology | 2016 | |
| Educating Family Caregivers for Older Adults About Delirium: A Systematic Review. | Bull MJ, Boaz L, Jermé M | Worldviews on evidence-based nursing / Sigma Theta Tau International, Honor Society of Nursing | 2016 | |
| Delirium: assessment and treatment of patients with cancer. PART 2. | Brown M, Hardy K | British journal of nursing (Mark Allen Publishing) | 2016 | |
| The Impact of Delirium After Cardiac Surgical Procedures on Postoperative Resource Use. | Brown CH, Laflam A, Max L, Lymar D, Neufeld KJ, Tian J, Shah AS, Whitman GJ, Hogue CW | The Annals of thoracic surgery | 2016 | |
| Sleep and delirium in unsedated patients in the intensive care unit. | Boesen HC, Andersen JH, Bendtsen AO, Jennum PJ | Acta anaesthesiologica Scandinavica | 2016 | |
| Delirium in cardiac ICU patients. | Bamalwa M, Mahmood SN, Praharaj SK | Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists | 2016 | |
| Under Pressure: Reduced Cerebral Perfusion as a Risk Factor for Postoperative Delirium in Lung Transplant Recipients. | Anderson BJ, Diamond JM | Annals of the American Thoracic Society | 2016 | |
| Serum protein S100 as marker of postoperative delirium after off-pump coronary artery bypass surgery: secondary analysis of two prospective randomized controlled trials. | Al Tmimi L, Van de Velde M, Meyns B, Meuris B, Sergeant P, Milisen K, Pottel H, Poesen K, Rex S | Clinical chemistry and laboratory medicine | 2016 | |
| Psychometric evaluation of the DMSS-4 in a cohort of elderly post-operative hip fracture patients with delirium. | Adamis D, Scholtens RM, de Jonghe A, van Munster BC, de Rooij SE, Meagher DJ | International psychogeriatrics / IPA | 2016 | |
| Incidence, Predictive Factors, and Effect of Delirium After Transcatheter Aortic Valve Replacement. | Abawi M, Nijhoff F, Agostoni P, Emmelot-Vonk MH, de Vries R, Doevendans PA, Stella PR | JACC. Cardiovascular interventions | 2016 | |
| Higher serum interieukin-6 is a strong postoperative predictor of delirium after isolated coronary artery bypass graft surgery | Sun, L. Ding, S. Feng, X. Wu, F. Su, P. Shen, Y. Zhao, H. Wu, Y. | Circulation | 2014 |
interleukin 6 |
| Deconstructing dementia and delirium hospital practice: using cultural historical activity theory to inform education approaches. | Teodorczuk A, Mukaetova-Ladinska E, Corbett S, Welfare M | Advances in health sciences education : theory and practice | 2015 |
Delirium, Dementia, England, Female, Focus Groups, Health Personnel, education, Hospitalization, Humans, Interviews as Topic, Male, Quality of Health Care |
| Assessment and Management of Delirium in Older Adults in the Emergency Department: Literature Review to Inform Development of a Novel Clinical Protocol. | Rosen T, Connors S, Clark S, Halpern A, Stern ME, DeWald J, Lachs MS, Flomenbaum N | Advanced emergency nursing journal | 2015 |
Aged, Clinical Protocols, Delirium, diagnosis, Education, Continuing, Emergency Service, Hospital, Humans |
| Gentle persuasive approaches: introducing an educational program on an orthopaedic unit for staff caring for patients with dementia and delirium. | Pizzacalla A, Montemuro M, Coker E, Martin LS, Gillies L, Robinson K, Pepper H, Benner J, Gusciora J | Orthopedic nursing | 2015 |
Critical Care Nursing, education, Curriculum, Delirium, nursing, Dementia, nursing, Humans, Medical Staff, Hospital, education, Nursing Staff, Hospital, education, Orthopedic Nursing, education, Persuasive Communication, Surgery Department, Hospital |
| The 3D-CAM provides a brief, easy to use, sensitive and specific delirium assessment tool for older hospitalised patients, both with and without dementia. | Pisani MA | Evidence-based mental health | 2015 |
Delirium, diagnosis, Female, Humans, Male, Neuropsychological Tests |
| The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU. | Kamdar BB, Combs MP, Colantuoni E, King LM, Niessen T, Neufeld KJ, Collop NA, Needham DM | Critical care (London, England) | 2015 | |
| Disturbed Serotonergic Neurotransmission and Oxidative Stress in Elderly Patients with Delirium. | Egberts A, Fekkes D, Wijnbeld EH, van der Ploeg MA, van Saase JL, Ziere G, van der Cammen TJ, Mattace-Raso FU | Dementia and geriatric cognitive disorders extra | 2015 | |
| Factors that contribute to underrecognition of delirium by registered nurses in acute care settings: a scoping review of the literature to explain this phenomenon. | El Hussein M, Hirst S, Salyers V | Journal of clinical nursing | 2015 |
Aged, Critical Care Nursing, Delirium, diagnosis, Dementia, complications, Humans |
| Delirium as letting go: An ethnographic analysis of hospice care and family moral experience. | Wright DK, Brajtman S, Cragg B, Macdonald ME | Palliative medicine | 2015 | |
| Non-convulsive status epilepticus: a practical approach to diagnosis in confused older people. | Woodford HJ, George J, Jackson M | Postgraduate medical journal | 2015 | |
| Systemic Corticosteroids and Transition to Delirium in Critically Ill Patients. | Wolters AE, Veldhuijzen DS, Zaal IJ, Peelen LM, van Dijk D, Devlin JW, Slooter AJ | Critical care medicine | 2015 |
Adrenal Cortex Hormones, administration & dosage, Adult, Critical Illness, Delirium, chemically induced, Dose-Response Relationship, Drug, Female, Humans, Intensive Care Units, Logistic Models, Male, Middle Aged, Odds Ratio, Prospective Studies, Psychiatric Status Rating Scales |
| Postoperative delirium assessed by post anesthesia care unit staff utilizing the Nursing Delirium Screening Scale: a prospective observational study of 1000 patients in a single Swiss institution. | Winter A, Steurer MP, Dullenkopf A | BMC anesthesiology | 2015 |
Anesthesia, adverse effects, Anesthesia Recovery Period, Delirium, chemically induced, Feasibility Studies, Female, Humans, Incidence, Male, Middle Aged, Nursing Staff, Hospital, Postoperative Complications, chemically induced, Prospective Studies, Risk Factors, Switzerland |
| Lived experience of the intensive care unit for patients who experienced delirium. | Whitehorne K, Gaudine A, Meadus R, Solberg S | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2015 | |
| Preoperative protein profiles in cerebrospinal fluid in elderly hip fracture patients at risk for delirium: A proteomics and validation study. | Westhoff D, Witlox J, van Aalst C, Scholtens RM, de Rooij SE, van Munster BC, de Jonghe JF, Houdijk AP, Eikelenboom P, van Westerloo DJ, van de Beek D, van Gool WA, Koenderman L | BBA clinical | 2015 | |
| Variable lung protective mechanical ventilation decreases incidence of postoperative delirium and cognitive dysfunction during open abdominal surgery. | Wang R, Chen J, Wu G | International journal of clinical and experimental medicine | 2015 | |
| Risk factors contributing to postoperative delirium in geriatric patients postorthopedic surgery. | Wang J, Li Z, Yu Y, Li B, Shao G, Wang Q | Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists | 2015 | |
| Review of delirium in patients with Parkinson's disease. | Vardy ER, Teodorczuk A, Yarnall AJ | Journal of neurology | 2015 | |
| Delirium detection and improved delirium management in older patients hospitalized for hip fracture. | Todd KS, Barry J, Hoppough S, McConnell E | International journal of orthopaedic and trauma nursing | 2015 | |
| Prospective evaluation of inappropriate unable-to-assess CAM-ICU documentations of critically ill adult patients. | Terry KJ, Anger KE, Szumita PM | Journal of intensive care | 2015 | |
| Delirium in intensive care unit patients under noninvasive ventilation: a multinational survey. | Tanaka LM, Salluh JI, Dal-Pizzol F, Barreto BB, Zantieff R, Tobar E, Esquinas A, Quarantini Lde C, Gusmao-Flores D | Revista Brasileira de terapia intensiva | 2015 |
Attitude of Health Personnel, Critical Care, Delirium, diagnosis, Health Care Surveys, Humans, Intensive Care Units, Noninvasive Ventilation |
| Acetylcholinesterase Inhibitors for Delirium in Older Adults. | Tampi RR, Tampi DJ, Ghori AK | American journal of Alzheimer's disease and other dementias | 2016 | |
| Influence of Granulocyte-Macrophage Colony-Stimulating Factor or Influenza Vaccination on HLA-DR, Infection and Delirium Days in Immunosuppressed Surgical Patients: Double Blind, Randomised Controlled Trial. | Spies C, Luetz A, Lachmann G, Renius M, von Haefen C, Wernecke KD, Bahra M, Schiemann A, Paupers M, Meisel C | PloS one | 2015 | |
| Validation of the confusion assessment method in detecting postoperative delirium in cardiac surgery patients. | Smulter N, Lingehall HC, Gustafson Y, Olofsson B, Engström KG | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2015 | |
| Risk Factors for Delirium After Spinal Surgery: A Meta-Analysis. | Shi C, Yang C, Gao R, Yuan W | World neurosurgery | 2015 |
Aged, Aged, 80 and over, Delirium, epidemiology, Humans, Neurosurgical Procedures, adverse effects, Postoperative Complications, epidemiology, Risk Factors, Spine, surgery |
| Valproic Acid for Treatment of Hyperactive or Mixed Delirium: Rationale and Literature Review. | Sher Y, Miller Cramer AC, Ament A, Lolak S, Maldonado JR | Psychosomatics | 2015 | |
| The Successful Aging After Elective Surgery Study: Cohort Description and Data Quality Procedures. | Schmitt EM, Saczynski JS, Kosar CM, Jones RN, Alsop DC, Fong TG, Metzger E, Cooper Z, Marcantonio ER, Travison T, Inouye SK, | Journal of the American Geriatrics Society | 2015 | |
| The Montreal Cognitive Assessment: Creating a Crosswalk with the Mini-Mental State Examination. | Saczynski JS, Inouye SK, Guess J, Jones RN, Fong TG, Nemeth E, Hodara A, Ngo L, Marcantonio ER | Journal of the American Geriatrics Society | 2015 |
Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Cross-Sectional Studies, Delirium, diagnosis, Dementia, diagnosis, Female, Humans, Male, Mild Cognitive Impairment, diagnosis, Neuropsychological Tests |
| Delirium After Hip Fracture: Still a Problem. | Rudolph JL | Anesthesia and analgesia | 2015 |
Delirium, mortality, Female, Hip Fractures, mortality, Humans, Male, Postoperative Complications, mortality |
| Delirium in patients with advanced cancer. | Lawlor PG, Bruera ED | Hematology/oncology clinics of North America | 2002 |
Causality, Communication, Conscious Sedation, Delirium, diagnosis, Diagnosis, Differential, Ethics, Medical, Evidence-Based Medicine, Family, psychology, Humans, Mass Screening, Neoplasm Staging, Neoplasms, complications, Palliative Care, methods, Patient Advocacy, Practice Guidelines as Topic, Severity of Illness Index |
| Postdischarge Clinical Outcomes in Older Medical Patients with an Emergency Department Stay-Associated Delirium Onset. | Bo M, Bonetto M, Bottignole G, Porrino P, Coppo E, Tibaldi M, Ceci G, Raspo S, Cappa G, Bellelli G | Journal of the American Geriatrics Society | 2016 | |
| Stop Using Antipsychotics to Treat or Prevent Delirium-They Are No Better Than Placebo. | Barry HC | American family physician | 2016 | |
| Higher C-Reactive Protein Levels Predict Postoperative Delirium in Older Patients Undergoing Major Elective Surgery: A Longitudinal Nested Case-Control Study. | Dillon ST, Vasunilashorn SM, Ngo L, Otu HH, Inouye SK, Jones RN, Alsop DC, Kuchel GA, Metzger ED, Arnold SE, Marcantonio ER, Libermann TA | Biological psychiatry | 2016 | |
| Sex Differences in Hip Fracture Surgery: Preoperative Risk Factors for Delirium and Postoperative Outcomes. | Oh ES, Sieber FE, Leoutsakos JM, Inouye SK, Lee HB | Journal of the American Geriatrics Society | 2016 | |
| A Decrease in the Volume of Gray Matter as a Risk Factor for Postoperative Delirium Revealed by an Atlas-based Method. | Shioiri A, Kurumaji A, Takeuchi T, Nemoto K, Arai H, Nishikawa T | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2016 | |
| Basic Geriatrics Knowledge Among Internal Medicine Trainees in a Teaching Hospital in Saudi Arabia. | Al-Aama T | Journal of cross-cultural gerontology | 2016 | |
| Expert opinions on the first-line pharmacological treatment for delirium in Japan: a conjoint analysis. | Okumura Y, Hatta K, Wada K, Takeuchi T, Kishi Y, | International psychogeriatrics / IPA | 2016 | |
| Cognitive Reserve and Postoperative Delirium in Older Adults. | Tow A, Holtzer R, Wang C, Sharan A, Kim SJ, Gladstein A, Blum Y, Verghese J | Journal of the American Geriatrics Society | 2016 | |
| Managing the Care of the Older Patient with Delirium and Dementia. | Seeganna C, Antai-Otong D | The Nursing clinics of North America | 2016 | |
| Associations Between Delirium and Preoperative Cerebrospinal Fluid C-Reactive Protein, Interleukin-6, and Interleukin-6 Receptor in Individuals with Acute Hip Fracture. | Neerland BE, Hall RJ, Seljeflot I, Frihagen F, MacLullich AM, Raeder J, Wyller TB, Watne LO | Journal of the American Geriatrics Society | 2016 | |
| Emerging Role of Melatonin and Melatonin Receptor Agonists in Sleep and Delirium in Intensive Care Unit Patients. | Mo Y, Scheer CE, Abdallah GT | Journal of intensive care medicine | 2016 | |
| International Psychogeriatrics Paper of the year 2015: the use of modern technology to tackle an old challenge - improving the diagnosis of delirium in the hospital setting. | Lautenschlager NT, Ames D | International psychogeriatrics / IPA | 2016 | |
| Application of Clinical Practice Guidelines for Pain, Agitation, and Delirium. | Krupp A, Balas MC | Critical care nursing clinics of North America | 2016 | |
| Early recognition of delirium in trauma patients. | Johnson K, Diana S, Todd J, McFarren A, Domb A, Mangram A, Veale K | Intensive & critical care nursing | 2016 | |
| A quick and easy delirium assessment for nonphysician research personnel. | Han JH, Wilson A, Graves AJ, Shintani A, Schnelle JF, Ely EW | The American journal of emergency medicine | 2016 | |
| Patients prone for postoperative delirium: preoperative assessment, perioperative prophylaxis, postoperative treatment. | Guenther U, Riedel L, Radtke FM | Current opinion in anaesthesiology | 2016 | |
| Family Caregivers' Knowledge of Delirium and Preferred Modalities for Receipt of Information. | Bull MJ, Boaz L, Sjostedt JM | Journal of applied gerontology : the official journal of the Southern Gerontological Society | 2016 | |
| Terminal delirium misdiagnosed as major psychiatric disorder: Palliative care in a psychiatric inpatient unit. | Aligeti S, Baig MR, Barrera FF | Palliative & supportive care | 2016 | |
| Risk Evaluation of Postoperative Delirium Using Comprehensive Geriatric Assessment in Elderly Patients with Esophageal Cancer. | Yamamoto M, Yamasaki M, Sugimoto K, Maekawa Y, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Rakugi H, Mori M, Doki Y | World journal of surgery | 2016 | |
| Assessment of inattention in the context of delirium screening: one size does not fit all! | Voyer P, Champoux N, Desrosiers J, Landreville P, Monette J, Savoie M, Carmichael PH, Richard S, Bédard A | International psychogeriatrics / IPA | 2016 | |
| Quantifying the Severity of a Delirium Episode Throughout Hospitalization: the Combined Importance of Intensity and Duration. | Vasunilashorn SM, Marcantonio ER, Gou Y, Pisani MA, Travison TG, Schmitt EM, Jones RN, Inouye SK | Journal of general internal medicine | 2016 | |
| Derivation and Validation of a Severity Scoring Method for the 3-Minute Diagnostic Interview for Confusion Assessment Method--Defined Delirium. | Vasunilashorn SM, Guess J, Ngo L, Fick D, Jones RN, Schmitt EM, Kosar CM, Saczynski JS, Travison TG, Inouye SK, Marcantonio ER | Journal of the American Geriatrics Society | 2016 | |
| The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor. | Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM | Anesthesia and analgesia | 2016 | |
| Piloting staff education in Australia to reduce falls in older hospital patients experiencing delirium. | Toye C, Kitchen S, Hill A, Edwards D, Sin M, Maher S | Nursing & health sciences | 2017 |
Accidental Falls, prevention & control, Australia, Delirium, complications, Female, Focus Groups, Humans, Inpatients, statistics & numerical data, Male, Nursing Staff, Hospital, education, Patient Safety, standards, Surveys and Questionnaires, Teaching, standards |
| Strange and scary memories of the intensive care unit: a qualitative, longitudinal study inspired by Ricoeur's interpretation theory. | Svenningsen H, Egerod I, Dreyer P | Journal of clinical nursing | 2016 | |
| How can postoperative delirium be predicted in advance? A secondary analysis comparing three methods of early assessment in elderly patients. | Stukenberg S, Franck M, Spies CD, Neuner B, Myers I, Radtke FM | Minerva anestesiologica | 2016 | |
| How trained volunteers can improve the quality of hospital care for older patients. A qualitative evaluation within the Hospital Elder Life Program (HELP). | Steunenberg B, van der Mast RC, Strijbos MJ, Inouye SK, Schuurmans MJ | Geriatric nursing (New York, N.Y.) | 2016 | |
| Preventive strategies and potential therapeutic interventions for delirium in sepsis. | Souza-Dantas VC, Póvoa P, Bozza F, Soares M, Salluh J | Hospital practice (1995) | 2016 | |
| Delirium after transcatheter aortic valve implantation via the femoral or apical route. | Sharma V, Katznelson R, Horlick E, Osten M, Styra R, Cusimano RJ, Carroll J, Djaiani G | Anaesthesia | 2016 | |
| Paraneoplastic neuropsychiatric syndrome presenting as delirium. | Roldan Urgoiti G, Sinnarajah A, Hussain S, Hao D | BMJ supportive & palliative care | 2016 | |
| [Anticholinergic burden and delirium in elderly patients during acute hospital admission]. | Rojo-Sanchís AM, Vélez-Díaz-Pallarés M, Muñoz García M, Delgado Silveira E, Bermejo Vicedo T, Cruz Jentoft A | Revista española de geriatría y gerontología | 2016 | |
| Evaluation of the delirium early monitoring system (DEMS). | Rippon D, Milisen K, Detroyer E, Mukaetova-Ladinska E, Harrison B, Schuurmans M, Pryor C, Teodorczuk A | International psychogeriatrics / IPA | 2016 | |
| A Pilot Randomized Controlled Trial of the Feasibility of a Multicomponent Delirium Prevention Intervention Versus Usual Care in Acute Stroke. | Rice KL, Bennett MJ, Berger L, Jennings B, Eckhardt L, Fabré-LaCoste N, Houghton D, Vidal G, Gropen T, Diggs E, Barry E, St John J, Mathew S, Egger A, Ryan S, Egger R, Galarneau D, Gaines K, Ely EW | The Journal of cardiovascular nursing | 2016 | |
| Delirium After Major Elective Noncardiac Surgery: Successful Aging After Elective Surgery Study. | Regal PJ | Journal of the American Geriatrics Society | 2016 | |
| Delirium in Survivors of Cardiac Arrest Treated With Mild Therapeutic Hypothermia. | Pollock JS, Hollenbeck RD, Wang L, Holmes B, Young MN, Peters M, Ely EW, McPherson JA, Vasilevskis EE | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2016 | |
| The Impact of Plasma Cholinergic Enzyme Activity and Other Risk Factors for the Development of Delirium in Patients Receiving Palliative Care. | Plaschke K, Petersen KA, Frankenhauser S, Weigand MA, Kopitz J, Bardenheuer HJ | Journal of pain and symptom management | 2016 | |
| Triggers and nursing influences on delirium in intensive care units. | Piao J, Jin Y, Lee SM | Nursing in critical care | 2016 | |
| Battery of behavioral tests in mice to study postoperative delirium. | Peng M, Zhang C, Dong Y, Zhang Y, Nakazawa H, Kaneki M, Zheng H, Shen Y, Marcantonio ER, Xie Z | Scientific reports | 2016 | |
| Delirium associated with olanzapine use in the elderly. | Park JI | Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society | 2017 | |
| Are stroke survivors with delirium at higher risk of post-stroke dementia? Current evidence and future directions. | Ojagbemi A, Ffytche DH | International journal of geriatric psychiatry | 2016 | |
| Detecting Delirium Superimposed on Dementia: Evaluation of the Diagnostic Performance of the Richmond Agitation and Sedation Scale. | Morandi A, Han JH, Meagher D, Vasilevskis E, Cerejeira J, Hasemann W, MacLullich AM, Annoni G, Trabucchi M, Bellelli G | Journal of the American Medical Directors Association | 2016 |