What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Elevated TDP-43 serum levels associated with postoperative delirium following major cardiac surgery
- Authors
- Simon, C. Graves, O. K. Akeju, O. McKay, T. B.
- Year
- 2025
- Journal
- Brain Behav Immun Health
- Abstract
BACKGROUND: Postoperative delirium is a recurring complication among vulnerable patients undergoing major cardiac surgery. While delirium has been associated with prodromal dementia, there is minimal evidence to support the causality of this nuanced relationship. Clarification as to how postoperative delirium might lead to neurodegenerative dementias, perhaps through evidence of contemporaneous biomarkers, would heighten the plausibility of a causal correlation. TAR DNA-binding protein 43 (TDP-43), a nuclear protein essential for transcriptional events, has been linked to pathological aggregation in Alzheimer’s disease (AD) and AD-related dementias (ADRD). METHODS: Circulating TDP-43 levels in cardiac surgical patients aged 60 years and older were evaluated in a biobank derived from the Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS) clinical trial. Serum total TDP-43 levels, measured with a single molecule array (Simoa), were compared across preoperative and postoperative day one timepoints according to delirium status assessed using the Confusion Assessment Method (CAM). To investigate the temporal changes in serum TDP-43, an independent validation cohort of 25 patients aged 60 years and older undergoing major cardiac surgery was analyzed. RESULTS: Total serum TDP-43 levels increased by 16.5% (95% CI: 5.9%-27.9%, p = 0.0021) on postoperative day one compared to baseline levels. This increase was more pronounced in patients who experienced delirium (median increase of 55.1%, 95% CI: 22.9%-96.4%, p = 0.0002). Further, these findings were conserved in multiple logistic regression models adjusting for treatment, age, sex, and baseline cognitive scores. In the validation cohort, TDP-43 levels were found to be significantly elevated immediately following cardiopulmonary bypass from the baseline, with a gradual decrease by postoperative day one. CONCLUSIONS: Our findings demonstrate that post-cardiac surgery delirium among vulnerable patients is associated with significant elevations in circulating TDP-43. This relationship suggests that TDP-43 may serve as a prognostic biomarker for acute neurological insults and blood-brain barrier integrity following cardiac surgery. Overall, our results provide mechanistic insights into the inter-relationship between postoperative delirium and subsequent cognitive impairment, potentially offering new avenues for early intervention in at-risk surgical patients.
- PMID
PMID: 40134937
PMCID: PMC11932660
- Keywords
Postoperative delirium, vulnerable patients, major cardiac surgery, prodromal dementia, TDP-43
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Pharmacologic agents for the prevention and treatment of delirium in patients undergoing cardiac surgery: systematic review and metaanalysis. | Mu JL, Lee A, Joynt GM | Critical care medicine | 2015 |
Adult, Cardiac Surgical Procedures, adverse effects, Delirium, drug therapy, Humans, Length of Stay |
| Efficacy and safety of dexmedetomidine for postoperative delirium in adult cardiac surgery on cardiopulmonary bypass. | Park JB, Bang SH, Chee HK, Kim JS, Lee SA, Shin JK | The Korean journal of thoracic and cardiovascular surgery | 2014 | |
| Delirium in critically ill patients in a tertiary care centre in western region of Nepal. | Thapa P, Chakrabortty PK, Khattri JB, Ramesh K, Sharma P | Kathmandu University medical journal (KUMJ) | 2014 |
Critical Illness, psychology, Cross-Sectional Studies, Delirium, epidemiology, Female, Humans, Incidence, Intensive Care Units, Male, Middle Aged, Nepal, epidemiology, Prevalence, Risk Factors, Tertiary Care Centers, statistics & numerical data |
| Cognitive and Brain Reserve and the Risk of Postoperative Delirium in Older Patients. | Saczynski JS, Inouye SK, Kosar C, Tommet D, Marcantonio ER, Fong T, Hshieh T, Vasunilashorn S, Metzger ED, Schmitt E, Alsop DC, Jones RN | The Lancet. Psychiatry | 2014 | |
| EFFECT OF PREOPERATIVE PAIN AND DEPRESSIVE SYMPTOMS ON THE DEVELOPMENT OF POSTOPERATIVE DELIRIUM. | Kosar CM, Tabloski PA, Travison TG, Jones RN, Schmitt EM, Puelle MR, Inloes JB, Saczynski JS, Marcantonio ER, Meagher D, Reid MC, Inouye SK | The Lancet. Psychiatry | 2014 | |
| Doing Damage in Delirium: The Hazards of Antipsychotic Treatment in Elderly Persons. | Inouye SK, Marcantonio ER, Metzger ED | The Lancet. Psychiatry | 2014 | |
| Neurotoxicity with Antimicrobials in the Elderly: A Review. | Mattappalil A, Mergenhagen KA | Clinical therapeutics | 2014 | |
| Postoperative delirium in older adults: best practice statement from the american geriatrics society. | , | Journal of the American College of Surgeons | 2015 | |
| Cognitive changes after surgery in the elderly: does minimally invasive surgery influence the incidence of postoperative cognitive changes compared to open colon surgery? | Tan CB, Ng J, Jeganathan R, Kawai F, Pan CX, Pollock S, Turner J, Cohen S, Chorost M | Dementia and geriatric cognitive disorders | 2015 | |
| A Prospective Comparison of Informant-based and Performance-based Dementia Screening Tools to Predict In-Hospital Delirium. | Zeng L, Josephson SA, Fukuda KA, Neuhaus J, Douglas VC | Alzheimer disease and associated disorders | 2015 | |
| Multiple anticholinergic medication use and risk of hospital admission for confusion or dementia. | Kalisch Ellett LM, Pratt NL, Ramsay EN, Barratt JD, Roughead EE | Journal of the American Geriatrics Society | 2014 |
Aged, 80 and over, Anticholinergic Syndrome, diagnosis, Australia, epidemiology, Cholinergic Antagonists, administration & dosage, Cohort Studies, Confusion, chemically induced, Dementia, chemically induced, Drug Therapy, Combination, adverse effects, Female, Hospitalization, statistics & numerical data, Humans, Incidence, Male, Retrospective Studies, Risk |
| The impact of frailty on postoperative delirium in cardiac surgery patients. | Jung P, Pereira MA, Hiebert B, Song X, Rockwood K, Tangri N, Arora RC | The Journal of thoracic and cardiovascular surgery | 2015 |
Age Factors, Aged, Aged, 80 and over, Aging, Cardiac Surgical Procedures, adverse effects, Chi-Square Distribution, Delirium, diagnosis, Elective Surgical Procedures, Female, Frail Elderly, Geriatric Assessment, Humans, Male, Middle Aged, Odds Ratio, Predictive Value of Tests, Prospective Studies, Questionnaires, Risk Assessment, Risk Factors, Treatment Outcome |
| A meta-analysis of critically ill patients reveals several potential risk factors for delirium. | Huai J, Ye X | General hospital psychiatry | 2014 |
Critical Illness, epidemiology, Delirium, epidemiology, Humans |
| A systematic review of outcomes following emergency transfer to hospital for residents of aged care facilities. | Dwyer R, Gabbe B, Stoelwinder JU, Lowthian J | Age and ageing | 2014 | |
| Delirium markers in older fallers: a case-control study. | Doherty K, Archambault E, Kelly B, Rudolph JL | Clinical interventions in aging | 2014 | |
| Heart rate variability in intensive care unit patients with delirium. | Zaal IJ, van der Kooi AW, van Schelven LJ, Oey PL, Slooter AJ | The Journal of neuropsychiatry and clinical neurosciences | 2015 | |
| Factors associated with family caregiver dissatisfaction with acute hospital care of older cognitively impaired relatives. | Whittamore KH, Goldberg SE, Bradshaw LE, Harwood RH, | Journal of the American Geriatrics Society | 2014 | |
| Risk prediction models for postoperative delirium: a systematic review and meta-analysis. | van Meenen LC, van Meenen DM, de Rooij SE, ter Riet G | Journal of the American Geriatrics Society | 2014 | |
| Risk Factors for and Prediction by Caregivers of Extubation Failure in ICU Patients: A Prospective Study. | Thille AW, Boissier F, Ghezala HB, Razazi K, Mekontso-Dessap A, Brun-Buisson C | Critical care medicine | 2014 | |
| Learning about the patient: an innovative interprofessional dementia and delirium education programme. | Teodorczuk A, Mukaetova-Ladinska E, Corbett S, Welfare M | The clinical teacher | 2014 | |
| Novel Therapeutic Strategies for Delirium in Patients With Cancer: A Preliminary Study. | Tanimukai H, Tsujimoto H, Matsuda Y, Tokoro A, Kanemura S, Watanabe M, Tsujio I, Maeda I, Takei K, Nakajima S, Taira T, Tokuyama M, Kai T, Okamoto Y, Goya S, Kashiwagi Y | The American journal of hospice & palliative care | 2016 | |
| Preoperative risk factors for postoperative delirium following hip fracture repair: a systematic review. | Oh ES, Li M, Fafowora TM, Inouye SK, Chen CH, Rosman LM, Lyketsos CG, Sieber FE, Puhan MA | International journal of geriatric psychiatry | 2015 | |
| Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults. | Mehta S, Cook D, Devlin JW, Skrobik Y, Meade M, Fergusson D, Herridge M, Steinberg M, Granton J, Ferguson N, Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Mallick R, Reynolds S, Keenan S, Burry L, , | Critical care medicine | 2015 | |
| Six-month outcomes of co-occurring delirium, depression, and dementia in long-term care. | McCusker J, Cole MG, Voyer P, Monette J, Champoux N, Ciampi A, Vu M, Belzile E | Journal of the American Geriatrics Society | 2014 | |
| Sensitivity and specificity of the animal fluency test for predicting postoperative delirium. | Long LS, Wolpaw JT, Leung JM | Canadian journal of anaesthesia = Journal canadien d'anesthesie | 2014 | |
| Effectiveness of implementing a wake up and breathe program on sedation and delirium in the ICU. | Khan BA, Fadel WF, Tricker JL, Carlos WG, Farber MO, Hui SL, Campbell NL, Ely EW, Boustani MA | Critical care medicine | 2014 |
Adult, Aged, Clinical Protocols, Coma, prevention & control, Critical Illness, Deep Sedation, methods, Delirium, prevention & control, Female, Humans, Incidence, Intensive Care Units, Length of Stay, Male, Middle Aged, Respiration, Respiration, Artificial, methods |
| Prospective analysis of adverse events in surgical treatment of degenerative spondylolisthesis. | Kelly AM, Batke JN, Dea N, Hartig DP, Fisher CG, Street JT | The spine journal : official journal of the North American Spine Society | 2014 | |
| Hospital readmission after hip fracture. | Kates SL, Behrend C, Mendelson DA, Cram P, Friedman SM | Archives of orthopaedic and trauma surgery | 2015 | |
| Anticholinergic Medication Use and Transition to Delirium in Critically Ill Patients: A Prospective Cohort Study. | Wolters AE, Zaal IJ, Veldhuijzen DS, Cremer OL, Devlin JW, van Dijk D, Slooter AJ | Critical care medicine | 2015 |
Academic Medical Centers, Age Factors, Aged, Cholinergic Antagonists, adverse effects, Comorbidity, Critical Illness, Delirium, chemically induced, Female, Health Status, Humans, Intensive Care Units, Male, Markov Chains, Middle Aged, Prospective Studies, Risk Factors |
| Preoperative risk factors of postoperative delirium after transurethral prostatectomy for benign prostatic hyperplasia. | Tai S, Xu L, Zhang L, Fan S, Liang C | International journal of clinical and experimental medicine | 2015 | |
| Incidence and risk factors of delirium in multi-center Thai surgical intensive care units: a prospective cohort study. | Pipanmekaporn T, Chittawatanarat K, Chaiwat O, Thawitsri T, Wacharasint P, Kongsayreepong S, | Journal of intensive care | 2015 | |
| Observational, longitudinal study of delirium in consecutive unselected acute medical admissions: age-specific rates and associated factors, mortality and re-admission. | Pendlebury ST, Lovett NG, Smith SC, Dutta N, Bendon C, Lloyd-Lavery A, Mehta Z, Rothwell PM | BMJ open | 2015 | |
| Routine cognitive screening in older patients admitted to acute medicine: abbreviated mental test score (AMTS) and subjective memory complaint versus Montreal Cognitive Assessment and IQCODE. | Pendlebury ST, Klaus SP, Mather M, de Brito M, Wharton RM | Age and ageing | 2015 | |
| Incidence and impact of delirium on clinical and functional outcomes in older patients hospitalized for acute cardiac diseases. | Noriega FJ, Vidán MT, Sánchez E, Díaz A, Serra-Rexach JA, Fernández-Avilés F, Bueno H | American heart journal | 2015 |
Acute Disease, Aged, Aged, 80 and over, Delirium, epidemiology, Female, Heart Diseases, complications, Humans, Inpatients, Male, Odds Ratio, Prevalence, Prognosis, Prospective Studies, Risk Factors, Spain, epidemiology, Survival Rate, trends |
| Dexmedetomidine reduces postoperative delirium after joint replacement in elderly patients with mild cognitive impairment. | Liu Y, Ma L, Gao M, Guo W, Ma Y | Aging clinical and experimental research | 2016 | |
| Factors Associated With the Development of Delirium in Elderly Patients in Intensive Care Units. | Lin WL, Chen YF, Wang J | The journal of nursing research : JNR | 2015 | |
| Screening in delirium: A pilot study of two screening tools, the Simple Query for Easy Evaluation of Consciousness and Simple Question in Delirium. | Lin HS, Eeles E, Pandy S, Pinsker D, Brasch C, Yerkovich S | Australasian journal on ageing | 2015 | |
| Anticholinergic Exposure During Rehabilitation: Cognitive and Physical Function Outcomes in Patients with Delirium Superimposed on Dementia. | Kolanowski A, Mogle J, Fick DM, Campbell N, Hill N, Mulhall P, Behrens L, Colancecco E, Boustani M, Clare L | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2015 | |
| Nurse perceptions of the Nursing Delirium Screening Scale in two palliative care inpatient units: a focus group study. | Hosie A, Lobb E, Agar M, Davidson PM, Chye R, Phillips J | Journal of clinical nursing | 2015 | |
| Postoperative Delirium in Cardiac Surgery: An Unavoidable Menace? | Hollinger A, Siegemund M, Goettel N, Steiner LA | Journal of cardiothoracic and vascular anesthesia | 2015 | |
| Cerebrospinal fluid cortisol and cytokines in delirium after hip fracture. | Hall RJ, Watne LO, Robertson I, Witlox J, Kalisvaart K, Seckl JR, Juliebø V, Wyller TB, MacLullich AM | Psychoneuroendocrinology | 2015 | |
| Cortisol diurnal rhythm and inflammation in delirium after hip fracture. | Hall RJ, Davis D, White TO, Robertson I, Seckl JR, MacLullich AM | Psychoneuroendocrinology | 2015 | |
| Prevalence and Characteristics of Pre-Operative Delirium in Hip Fracture Patients. | Freter S, Dunbar M, Koller K, MacKnight C, Rockwood K | Gerontology | 2015 | |
| Risk of Pre-and Post-Operative Delirium and the Delirium Elderly At Risk (DEAR) Tool in Hip Fracture Patients. | Freter S, Dunbar M, Koller K, MacKnight C, Rockwood K | Canadian geriatrics journal : CGJ | 2015 | |
| Informal caregivers and detection of delirium in postacute care: a correlational study of the confusion assessment method (CAM), confusion assessment method-family assessment method (CAM-FAM) and DSM-IV criteria. | Flanagan NM, Spencer G | International journal of older people nursing | 2016 | |
| AACN CSI Academy, part 3: Introducing the Massachusetts CSI Nursing Delirium Collaborative. | DiLibero J, Edwards E, Hanson D | Nursing management | 2015 | |
| Emergency Department Delirium Screening Improves Care and Reduces Revisits for the Older Adult Patient. | Delaney M, Pepin J, Somes J | Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association | 2015 | |
| Can Intraoperative Processed EEG Predict Postoperative Cognitive Dysfunction in the Elderly? | Deiner S, Luo X, Silverstein JH, Sano M | Clinical therapeutics | 2015 | |
| Delirium Screening: A Systematic Review of Delirium Screening Tools in Hospitalized Patients. | De J, Wand AP | The Gerontologist | 2015 | |
| Existential Absence: The Lived Experience of Family Members During Their Older Loved One's Delirium. | Day J, Higgins I | Qualitative health research | 2015 | |
| Cognitive Dysfunction, Delirium, and Stroke in Cardiac Surgery Patients. | Cropsey C, Kennedy J, Han J, Pandharipande P | Seminars in cardiothoracic and vascular anesthesia | 2015 | |
| Beyond Urinary Tract Infections (UTIs) and Delirium: A Systematic Review of UTIs and Neuropsychiatric Disorders. | Chae JH, Miller BJ | Journal of psychiatric practice | 2015 | |
| The Association of Brain MRI Characteristics and Postoperative Delirium in Cardiac Surgery Patients. | Brown CH, Faigle R, Klinker L, Bahouth M, Max L, LaFlam A, Neufeld KJ, Mandal K, Gottesman RF, Hogue CW | Clinical therapeutics | 2015 | |
| Identifying and managing patients with delirium in acute care settings. | Bond P, Goudie K | Nursing older people | 2015 |
Delirium, diagnosis, Humans, Scotland |
| Nursing Education Program Improves Care for Patients With Delirium. | Becze E | ONS connect | 2015 |
Delirium, complications, Education, Nursing, organization & administration, Humans, Neoplasms, complications, Quality of Health Care |
| Use of a Multimodal Implementation Strategy to Improve Delirium Screening by Nurses on an Acute Care for Elders Unit. | Afriyie-Boateng M, Loftus C, Hamelin MA | Worldviews on evidence-based nursing / Sigma Theta Tau International, Honor Society of Nursing | 2015 | |
| Benzodiazepine-associated delirium in critically ill adults. | Zaal IJ, Devlin JW, Hazelbag M, Klein Klouwenberg PM, van der Kooi AW, Ong DS, Cremer OL, Groenwold RH, Slooter AJ | Intensive care medicine | 2015 | |
| Dopamine Administration is a Risk Factor for Delirium in Patients Undergoing Coronary Artery Bypass Surgery. | Yilmaz S, Aksoy E, Diken AI, Yalcinkaya A, Erol ME, Cagli K | Heart, lung & circulation | 2016 | |
| Different MMSE Score Is Associated with Postoperative Delirium in Young-Old and Old-Old Adults. | Wu Y, Shi Z, Wang M, Zhu Y, Li C, Li G, Marcantonio ER, Xie Z, Shen Y | PloS one | 2015 | |
| Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial. | Whitlock RP, Devereaux PJ, Teoh KH, Lamy A, Vincent J, Pogue J, Paparella D, Sessler DI, Karthikeyan G, Villar JC, Zuo Y, Avezum Á, Quantz M, Tagarakis GI, Shah PJ, Abbasi SH, Zheng H, Pettit S, Chrolavicius S, Yusuf S, | Lancet (London, England) | 2015 |
Aged, Aged, 80 and over, Anti-Inflammatory Agents, therapeutic use, Cardiopulmonary Bypass, adverse effects, Double-Blind Method, Female, Humans, Male, Methylprednisolone, therapeutic use, Middle Aged, Systemic Inflammatory Response Syndrome, etiology |
| Does Apolipoprotein E Genotype Increase Risk of Postoperative Delirium? | Vasunilashorn SM, Ngo L, Kosar CM, Fong TG, Jones RN, Inouye SK, Marcantonio ER | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2015 | |
| New aspects of delirium in elderly patients with critical limb ischemia. | van Eijsden WA, Raats JW, Mulder PG, van der Laan L | Clinical interventions in aging | 2015 | |
| Incidence of and Risk Factors for Delirium After Cardiac Surgery at a Quaternary Care Center: A Retrospective Cohort Study. | Tse L, Schwarz SK, Bowering JB, Moore RL, Barr AM | Journal of cardiothoracic and vascular anesthesia | 2015 | |
| Is delirium being detected in emergency? | Traynor V, Cordato N, Burns P, Xu Y, Britten N, Duncan K, DeVries L, McKinnon C | Australasian journal on ageing | 2016 |
Age Factors, Aged, Cognition, Delirium, diagnosis, Diagnostic Errors, Emergency Services, Psychiatric, Female, Geriatric Assessment, Hospitals, Urban, Humans, Incidence, Male, Medical Audit, Medical Records, New South Wales, epidemiology, Predictive Value of Tests, Psychiatric Status Rating Scales |
| Symptoms of Posttraumatic Stress after Intensive Care Delirium. | Svenningsen H, Egerod I, Christensen D, Tønnesen EK, Frydenberg M, Videbech P | BioMed research international | 2015 | |
| Constipation is independently associated with delirium in critically ill ventilated patients. | Smonig R, Wallenhorst T, Bouju P, Letheulle J, Le Tulzo Y, Tadié JM, Gacouin A | Intensive care medicine | 2015 | |
| Surgery plus anesthesia induces loss of attention in mice. | Ren Q, Peng M, Dong Y, Zhang Y, Chen M, Yin N, Marcantonio ER, Xie Z | Frontiers in cellular neuroscience | 2015 | |
| The diurnal profile of melatonin during delirium in elderly patients--preliminary results. | Piotrowicz K, Klich-Rączka A, Pac A, Zdzienicka A, Grodzicki T | Experimental gerontology | 2015 | |
| Cognitive and functional status predictors of delirium and delirium severity after coronary artery bypass graft surgery: an interim analysis of the Neuropsychiatric Outcomes After Heart Surgery study. | Oldham MA, Hawkins KA, Yuh DD, Dewar ML, Darr UM, Lysyy T, Lee HB | International psychogeriatrics / IPA | 2015 | |
| Preoperative physical activity in relation to postoperative delirium in elective cardiac surgery patients. | Ogawa M, Izawa KP, Kitamura A, Ono R, Satomi-Kobayashi S, Sakai Y, Okita Y | International journal of cardiology | 2015 | |
| Predicting delirium: a review of risk-stratification models. | Newman MW, O'Dwyer LC, Rosenthal L | General hospital psychiatry | 2015 | |
| Long-Term Outcomes of Older Adults with and Without Delirium Immediately After Recovery from General Anesthesia for Surgery. | Neufeld KJ, Leoutsakos JM, Oh E, Sieber FE, Chandra A, Ghosh A, Schretlen DJ, Needham DM | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2015 | |
| Clinical impact of delirium and antipsychotic therapy: 10-Year experience from a referral coronary care unit. | Naksuk N, Thongprayoon C, Park JY, Sharma S, Gaba P, Rosenbaum AN, Peeraphatdit T, Hu TY, Bell MR, Herasevich V, Brady PA, Kapa S, Asirvatham SJ | European heart journal. Acute cardiovascular care | 2015 | |
| Hematoma Locations Predicting Delirium Symptoms After Intracerebral Hemorrhage. | Naidech AM, Polnaszek KL, Berman MD, Voss JL | Neurocritical care | 2015 | |
| The effects of a tailored intensive care unit delirium prevention protocol: A randomized controlled trial. | Moon KJ, Lee SM | International journal of nursing studies | 2015 |
Cognition, Delirium, prevention & control, Humans, Intensive Care Units, Single-Blind Method |
| Months backward test: A review of its use in clinical studies. | Meagher J, Leonard M, Donoghue L, O'Regan N, Timmons S, Exton C, Cullen W, Dunne C, Adamis D, Maclullich AJ, Meagher D | World journal of psychiatry | 2015 | |
| An exercise program with patient's involvement and family support can modify the cognitive and affective trajectory of acutely hospitalized older medical patients: a pilot study. | Martínez-Velilla N, Garrués-Irisarri M, Ibañez-Beroiz B, Gil-Cabañas J, Richarte-García A, Idoate-Saralegui F, de Paz PC, Cambra K | Aging clinical and experimental research | 2015 | |
| Comprehensive Geriatric Assessment is a useful predictive tool for postoperative delirium after gastrointestinal surgery in old-old adults. | Maekawa Y, Sugimoto K, Yamasaki M, Takeya Y, Yamamoto K, Ohishi M, Ogihara T, Shintani A, Doki Y, Mori M, Rakugi H | Geriatrics & gerontology international | 2016 | |
| Acute traumatic and depressive symptoms in family members of hospitalized individuals with delirium. | Lloyd RB, Rosenthal LJ | International journal of psychiatry in medicine | 2015 | |
| Influence of Ketamine on Early Postoperative Cognitive Function After Orthopedic Surgery in Elderly Patients. | Lee KH, Kim JY, Kim JW, Park JS, Lee KW, Jeon SY | Anesthesiology and pain medicine | 2015 | |
| Detection of Delirium in Hospitalized Older General Medicine Patients: A Comparison of the 3D-CAM and CAM-ICU. | Kuczmarska A, Ngo LH, Guess J, O'Connor MA, Branford-White L, Palihnich K, Gallagher J, Marcantonio ER | Journal of general internal medicine | 2016 | |
| Antipsychotic medications for the treatment of delirium: a systematic review and meta-analysis of randomised controlled trials. | Kishi T, Hirota T, Matsunaga S, Iwata N | Journal of neurology, neurosurgery, and psychiatry | 2015 | |
| Differential Associations Between Delirium and Mortality According to Delirium Subtype and Age: A Prospective Cohort Study. | Kim SY, Kim SW, Kim JM, Shin IS, Bae KY, Shim HJ, Bae WK, Cho SH, Chung IJ, Yoon JS | Psychosomatic medicine | 2015 | |
| Development of Delirium in the Intensive Care Unit in Patients after Endovascular Aortic Repair: A Retrospective Evaluation of the Prevalence and Risk Factors. | Kawatani Y, Nakamura Y, Hayashi Y, Taneichi T, Ito Y, Kurobe H, Suda Y, Hori T | Critical care research and practice | 2015 | |
| Non-pharmacological interventions for sleep promotion in the intensive care unit. | Hu RF, Jiang XY, Chen J, Zeng Z, Chen XY, Li Y, Huining X, Evans DJ | The Cochrane database of systematic reviews | 2015 | |
| Clinical deterioration in older adults with delirium during early hospitalisation: a prospective cohort study. | Hsieh SJ, Madahar P, Hope AA, Zapata J, Gong MN | BMJ open | 2015 | |
| Human herpesvirus 6B reactivation and delirium are frequent and associated events after cord blood transplantation. | Hill JA, Boeckh M, Leisenring WM, Xie H, Adler AL, Huang ML, Fann JR, Delaney C, Zerr DM | Bone marrow transplantation | 2015 | |
| Risk factors for delirium after on-pump cardiac surgery: a systematic review. | Gosselt AN, Slooter AJ, Boere PR, Zaal IJ | Critical care (London, England) | 2015 | |
| Effect of Delirium and Other Major Complications on Outcomes After Elective Surgery in Older Adults. | Gleason LJ, Schmitt EM, Kosar CM, Tabloski P, Saczynski JS, Robinson T, Cooper Z, Rogers SO, Jones RN, Marcantonio ER, Inouye SK | JAMA surgery | 2015 | |
| Intraoperative Electroencephalogram Suppression Predicts Postoperative Delirium. | Fritz BA, Kalarickal PL, Maybrier HR, Muench MR, Dearth D, Chen Y, Escallier KE, Ben Abdallah A, Lin N, Avidan MS | Anesthesia and analgesia | 2016 | |
| Preliminary development of an ultrabrief two-item bedside test for delirium. | Fick DM, Inouye SK, Guess J, Ngo LH, Jones RN, Saczynski JS, Marcantonio ER | Journal of hospital medicine | 2015 | |
| The Frequency, Characteristics, and Outcomes Among Cancer Patients With Delirium Admitted to an Acute Palliative Care Unit. | de la Cruz M, Ransing V, Yennu S, Wu J, Liu D, Reddy A, Delgado-Guay M, Bruera E | The oncologist | 2015 | |
| Partial and No Recovery from Delirium in Older Hospitalized Adults: Frequency and Baseline Risk Factors. | Cole MG, Bailey R, Bonnycastle M, McCusker J, Fung S, Ciampi A, Belzile E, Bai C | Journal of the American Geriatrics Society | 2015 |
Activities of Daily Living, Aged, Aged, 80 and over, Delirium, physiopathology, Dementia, complications, Female, Follow-Up Studies, Humans, Inpatients, Intelligence Tests, Male, Prognosis, Risk Factors |
| Short-Form Mini Nutritional Assessment as a useful method of predicting the development of postoperative delirium in elderly patients undergoing orthopedic surgery. | Chu CS, Liang CK, Chou MY, Lin YT, Hsu CJ, Chou PH, Chu CL | General hospital psychiatry | 2016 | |
| Under-detection of delirium and impact of neurocognitive deficits on in-hospital mortality among acute geriatric and medical wards. | Bellelli G, Nobili A, Annoni G, Morandi A, Djade CD, Meagher DJ, Maclullich AM, Davis D, Mazzone A, Tettamanti M, Mannucci PM, | European journal of internal medicine | 2015 | |
| Timing Is Critical in Determining the Association Between Delirium and S100 Calcium-Binding Protein B. | Beishuizen SJ, Scholtens RM, Vellekoop AE, Vrouenraets BC, Westhoff D, van de Beek D, de Rooij SE, van Munster BC | Journal of the American Geriatrics Society | 2015 | |
| Delirium monitoring and patient outcomes in a general intensive care unit. | Andrews L, Silva SG, Kaplan S, Zimbro K | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2015 |
Aged, Aged, 80 and over, Delirium, diagnosis, Female, Humans, Intensive Care, methods, Intensive Care Units, Length of Stay, statistics & numerical data, Male, Neuropsychological Tests, statistics & numerical data, Nursing Assessment, methods, Outcome and Process Assessment (Health Care), statistics & numerical data, Questionnaires, Respiration, Artificial, statistics & numerical data, Retrospective Studies |
| Evaluating attention in delirium: A comparison of bedside tests of attention. | Adamis D, Meagher D, Murray O, O'Neill D, O'Mahony E, Mulligan O, McCarthy G | Geriatrics & gerontology international | 2016 | |
| Prevention of delirium (POD) for older people in hospital: study protocol for a randomised controlled feasibility trial. | Young J, Cheater F, Collinson M, Fletcher M, Forster A, Godfrey M, Green J, Anwar S, Hartley S, Hulme C, Inouye SK, Meads D, Santorelli G, Siddiqi N, Smith J, Teale E, Farrin AJ | Trials | 2015 | |
| Intraoperative hypotension and delirium after on-pump cardiac surgery. | Wesselink EM, Kappen TH, van Klei WA, Dieleman JM, van Dijk D, Slooter AJ | British journal of anaesthesia | 2015 |
Adult, Aged, Aged, 80 and over, Antiemetics, administration & dosage, Cardiac Surgical Procedures, Cohort Studies, Delirium, epidemiology, Dexamethasone, administration & dosage, Female, Humans, Hypotension, epidemiology, Intraoperative Complications, epidemiology, Male, Middle Aged, Postoperative Complications, epidemiology, Young Adult |