What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Effect of Delirium and Other Major Complications on Outcomes After Elective Surgery in Older Adults. | Gleason LJ, Schmitt EM, Kosar CM, Tabloski P, Saczynski JS, Robinson T, Cooper Z, Rogers SO, Jones RN, Marcantonio ER, Inouye SK | JAMA surgery | 2015 | |
| Intraoperative Electroencephalogram Suppression Predicts Postoperative Delirium. | Fritz BA, Kalarickal PL, Maybrier HR, Muench MR, Dearth D, Chen Y, Escallier KE, Ben Abdallah A, Lin N, Avidan MS | Anesthesia and analgesia | 2016 | |
| Preliminary development of an ultrabrief two-item bedside test for delirium. | Fick DM, Inouye SK, Guess J, Ngo LH, Jones RN, Saczynski JS, Marcantonio ER | Journal of hospital medicine | 2015 | |
| The Frequency, Characteristics, and Outcomes Among Cancer Patients With Delirium Admitted to an Acute Palliative Care Unit. | de la Cruz M, Ransing V, Yennu S, Wu J, Liu D, Reddy A, Delgado-Guay M, Bruera E | The oncologist | 2015 | |
| Partial and No Recovery from Delirium in Older Hospitalized Adults: Frequency and Baseline Risk Factors. | Cole MG, Bailey R, Bonnycastle M, McCusker J, Fung S, Ciampi A, Belzile E, Bai C | Journal of the American Geriatrics Society | 2015 |
Activities of Daily Living, Aged, Aged, 80 and over, Delirium, physiopathology, Dementia, complications, Female, Follow-Up Studies, Humans, Inpatients, Intelligence Tests, Male, Prognosis, Risk Factors |
| Short-Form Mini Nutritional Assessment as a useful method of predicting the development of postoperative delirium in elderly patients undergoing orthopedic surgery. | Chu CS, Liang CK, Chou MY, Lin YT, Hsu CJ, Chou PH, Chu CL | General hospital psychiatry | 2016 | |
| Under-detection of delirium and impact of neurocognitive deficits on in-hospital mortality among acute geriatric and medical wards. | Bellelli G, Nobili A, Annoni G, Morandi A, Djade CD, Meagher DJ, Maclullich AM, Davis D, Mazzone A, Tettamanti M, Mannucci PM, | European journal of internal medicine | 2015 | |
| Timing Is Critical in Determining the Association Between Delirium and S100 Calcium-Binding Protein B. | Beishuizen SJ, Scholtens RM, Vellekoop AE, Vrouenraets BC, Westhoff D, van de Beek D, de Rooij SE, van Munster BC | Journal of the American Geriatrics Society | 2015 | |
| Delirium monitoring and patient outcomes in a general intensive care unit. | Andrews L, Silva SG, Kaplan S, Zimbro K | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2015 |
Aged, Aged, 80 and over, Delirium, diagnosis, Female, Humans, Intensive Care, methods, Intensive Care Units, Length of Stay, statistics & numerical data, Male, Neuropsychological Tests, statistics & numerical data, Nursing Assessment, methods, Outcome and Process Assessment (Health Care), statistics & numerical data, Questionnaires, Respiration, Artificial, statistics & numerical data, Retrospective Studies |
| Evaluating attention in delirium: A comparison of bedside tests of attention. | Adamis D, Meagher D, Murray O, O'Neill D, O'Mahony E, Mulligan O, McCarthy G | Geriatrics & gerontology international | 2016 | |
| Prevention of delirium (POD) for older people in hospital: study protocol for a randomised controlled feasibility trial. | Young J, Cheater F, Collinson M, Fletcher M, Forster A, Godfrey M, Green J, Anwar S, Hartley S, Hulme C, Inouye SK, Meads D, Santorelli G, Siddiqi N, Smith J, Teale E, Farrin AJ | Trials | 2015 | |
| Intraoperative hypotension and delirium after on-pump cardiac surgery. | Wesselink EM, Kappen TH, van Klei WA, Dieleman JM, van Dijk D, Slooter AJ | British journal of anaesthesia | 2015 |
Adult, Aged, Aged, 80 and over, Antiemetics, administration & dosage, Cardiac Surgical Procedures, Cohort Studies, Delirium, epidemiology, Dexamethasone, administration & dosage, Female, Humans, Hypotension, epidemiology, Intraoperative Complications, epidemiology, Male, Middle Aged, Postoperative Complications, epidemiology, Young Adult |
| Cytokines and Postoperative Delirium in Older Patients Undergoing Major Elective Surgery. | Vasunilashorn SM, Ngo L, Inouye SK, Libermann TA, Jones RN, Alsop DC, Guess J, Jastrzebski S, McElhaney JE, Kuchel GA, Marcantonio ER | The journals of gerontology. Series A, Biological sciences and medical sciences | 2015 | |
| Is preoperative state anxiety a risk factor for postoperative delirium among elderly hip fracture patients? | Van Grootven B, Detroyer E, Devriendt E, Sermon A, Deschodt M, Flamaing J, Dubois C, Milisen K | Geriatrics & gerontology international | 2016 | |
| Prevalence, course and factors associated with delirium in elderly patients with advanced cancer: a longitudinal observational study. | Uchida M, Okuyama T, Ito Y, Nakaguchi T, Miyazaki M, Sakamoto M, Kamiya T, Sato S, Takeyama H, Joh T, Meagher D, Akechi T | Japanese journal of clinical oncology | 2015 | |
| Incidence and risk factors of postoperative delirium in elderly patients who underwent laparoscopic surgery for colorectal cancer. | Tei M, Wakasugi M, Kishi K, Tanemura M, Akamatsu H | International journal of colorectal disease | 2016 | |
| Factors predicting perioperative delirium and acute exacerbation of behavioral and psychological symptoms of dementia based on admission data in elderly patients with proximal femoral fracture: A retrospective study. | Tanaka T | Geriatrics & gerontology international | 2016 | |
| Impact of surgical approach on postoperative delirium in elderly patients undergoing gastrectomy: laparoscopic versus open approaches. | Shin YH, Kim DK, Jeong HJ | Korean journal of anesthesiology | 2015 | |
| Frequency and Outcome of Neuroleptic Rotation in the Management of Delirium in Patients with Advanced Cancer. | Shin SH, Hui D, Chisholm G, Kang JH, Allo J, Williams J, Bruera E | Cancer research and treatment : official journal of Korean Cancer Association | 2015 | |
| Prognostic Significance of Postoperative Subsyndromal Delirium. | Shim J, DePalma G, Sands LP, Leung JM | Psychosomatics | 2015 | |
| Relationship between cobalamin deficiency and delirium in elderly patients undergoing cardiac surgery. | Sevuk U, Baysal E, Ay N, Altas Y, Altindag R, Yaylak B, Alp V, Demirtas E | Neuropsychiatric disease and treatment | 2015 | |
| Performance of the Delirium Rating Scale-Revised-98 Against Different Delirium Diagnostic Criteria in a Population With a High Prevalence of Dementia. | Sepulveda E, Franco JG, Trzepacz PT, Gaviria AM, Viñuelas E, Palma J, Ferré G, Grau I, Vilella E | Psychosomatics | 2015 | |
| Prognostic value and risk factors of delirium in emergency patients with decompensated heart failure. | Rizzi MA, Torres Bonafonte OH, Alquezar A, Herrera Mateo S, Piñera P, Puig M, Benito S, Ruiz D | Journal of the American Medical Directors Association | 2015 | |
| Risk Factors and Outcomes for Postoperative Delirium after Major Surgery in Elderly Patients. | Raats JW, van Eijsden WA, Crolla RM, Steyerberg EW, van der Laan L | PloS one | 2015 | |
| The Language of Delirium: Keywords for Identifying Delirium from Medical Records. | Puelle MR, Kosar CM, Xu G, Schmitt E, Jones RN, Marcantonio ER, Cooper Z, Inouye SK, Saczynski JS | Journal of gerontological nursing | 2015 |
Aged, Aged, 80 and over, Cohort Studies, Delirium, diagnosis, Electronic Health Records, Female, Humans, Male, Terminology as Topic |
| Delirium is a robust predictor of morbidity and mortality among critically ill patients treated in the cardiac intensive care unit. | Pauley E, Lishmanov A, Schumann S, Gala GJ, van Diepen S, Katz JN | American heart journal | 2015 |
APACHE, Acute Kidney Injury, epidemiology, Age Factors, Aged, Cohort Studies, Comorbidity, Critical Illness, Delirium, epidemiology, Female, Heart Arrest, epidemiology, Heart Diseases, epidemiology, Heart Valve Diseases, epidemiology, Humans, Intensive Care Units, Length of Stay, Linear Models, Logistic Models, Male, Middle Aged, Multivariate Analysis, Myocardial Infarction, epidemiology, North Carolina, epidemiology, Prevalence, Prognosis, Respiratory Insufficiency, epidemiology, Sepsis, epidemiology, Severity of Illness Index |
| Return to work six months after burn: A prospective study at the Helsinki Burn Center. | Palmu R, Partonen T, Suominen K, Vuola J, Isometsä E | Burns : journal of the International Society for Burn Injuries | 2015 | |
| Delirium, how does it end? Mortality as an outcome in older medical inpatients. | Muresan ML, Adamis D, Murray O, O'Mahony E, McCarthy G | International journal of geriatric psychiatry | 2015 | |
| Delirium superimposed on dementia: A quantitative and qualitative evaluation of informal caregivers and health care staff experience. | Morandi A, Lucchi E, Turco R, Morghen S, Guerini F, Santi R, Gentile S, Meagher D, Voyer P, Fick DM, Schmitt EM, Inouye SK, Trabucchi M, Bellelli G | Journal of psychosomatic research | 2015 |
Caregivers, psychology, Cohort Studies, Delirium, nursing, Dementia, nursing, Female, Humans, Male, Middle Aged, Patient Care Team, standards, Prospective Studies, Surveys and Questionnaires |
| Delirium superimposed on dementia: A quantitative and qualitative evaluation of patient experience. | Morandi A, Lucchi E, Turco R, Morghen S, Guerini F, Santi R, Gentile S, Meagher D, Voyer P, Fick D, Schmitt EM, Inouye SK, Trabucchi M, Bellelli G | Journal of psychosomatic research | 2015 | |
| Delirium and Circadian Rhythm of Melatonin During Weaning From Mechanical Ventilation: An Ancillary Study of a Weaning Trial. | Mekontso Dessap A, Roche-Campo F, Launay JM, Charles-Nelson A, Katsahian S, Brun-Buisson C, Brochard L | Chest | 2015 |
Aged, Ancillary Services, Hospital, Circadian Rhythm, Delirium, etiology, Female, Follow-Up Studies, Humans, Intensive Care Units, Male, Melatonin, analogs & derivatives, Middle Aged, Respiration, Artificial, Time Factors, Ventilator Weaning, methods |
| Chemotherapeutic drugs that penetrate the blood-brain barrier affect the development of hyperactive delirium in cancer patients. | Matsuoka H, Yoshiuchi K, Koyama A, Otsuka M, Nakagawa K | Palliative & supportive care | 2015 | |
| Patient factors associated with 30-day morbidity, mortality, and length of stay after surgery for subdural hematoma: a study of the American College of Surgeons National Surgical Quality Improvement Program. | Lukasiewicz AM, Grant RA, Basques BA, Webb ML, Samuel AM, Grauer JN | Journal of neurosurgery | 2015 | |
| Preoperative Sleep Disruption and Postoperative Delirium. | Leung JM, Sands LP, Newman S, Meckler G, Xie Y, Gay C, Lee K | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine | 2015 | |
| Anesthesiologic regimen and intraoperative delirium in deep brain stimulation surgery for Parkinson's disease. | Lange M, Zech N, Seemann M, Janzen A, Halbing D, Zeman F, Doenitz C, Rothenfusser E, Hansen E, Brawanski A, Schlaier J | Journal of the neurological sciences | 2015 | |
| Predicting outcome in older hospital patients with delirium: a systematic literature review. | Jackson TA, Wilson D, Richardson S, Lord JM | International journal of geriatric psychiatry | 2016 | |
| Enhancing Cognitive Aging: Clinical Highlights of a Report From the Institute of Medicine. | Inouye SK | Annals of internal medicine | 2015 | |
| Risk factors associated with postoperative delirium after surgery for oral cancer. | Hasegawa T, Saito I, Takeda D, Iwata E, Yonezawa N, Kakei Y, Sakakibara A, Akashi M, Minamikawa T, Komori T | Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery | 2015 | |
| The Diagnostic Performance of the Richmond Agitation Sedation Scale for Detecting Delirium in Older Emergency Department Patients. | Han JH, Vasilevskis EE, Schnelle JF, Shintani A, Dittus RS, Wilson A, Ely EW | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine | 2015 |
Age Factors, Aged, Aged, 80 and over, Clinical Protocols, Consciousness, Delirium, diagnosis, Emergency Service, Hospital, organization & administration, Female, Humans, Male, Prospective Studies, Reproducibility of Results, Sensitivity and Specificity |
| Risk factors and clinical aspects of delirium in elderly hospitalized patients in Iran. | Foroughan M, Delbari A, Said SE, AkbariKamrani AA, Rashedi V, Zandi T | Aging clinical and experimental research | 2016 | |
| The interface between delirium and dementia in elderly adults. | Fong TG, Davis D, Growdon ME, Albuquerque A, Inouye SK | The Lancet. Neurology | 2015 | |
| Predictors of Long-Term Mortality in Oldest Old Patients (90+) Hospitalized to Medical Wards via the Emergency Department: The SAFES Cohort. | de Boissieu P, Mahmoudi R, Hentzien M, Toquet S, Novella JL, Blanchard F, Jolly D, Dramé M | The journal of nutrition, health & aging | 2015 | |
| Exogenous Melatonin for Delirium Prevention: a Meta-analysis of Randomized Controlled Trials. | Chen S, Shi L, Liang F, Xu L, Desislava D, Wu Q, Zhang J | Molecular neurobiology | 2015 | |
| Efficacy of Non-Pharmacological Interventions to Prevent and Treat Delirium in Older Patients: A Systematic Overview. The SENATOR project ONTOP Series. | Abraha I, Trotta F, Rimland JM, Cruz-Jentoft A, Lozano-Montoya I, Soiza RL, Pierini V, Dessì Fulgheri P, Lattanzio F, O'Mahony D, Cherubini A | PloS one | 2015 | |
| Effect of dexmedetomidine on preventing agitation and delirium after microvascular free flap surgery: a randomized, double-blind, control study. | Yang X, Li Z, Gao C, Liu R | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | 2015 | |
| Intraoperative tight glucose control using hyperinsulinemic normoglycemia increases delirium after cardiac surgery. | Saager L, Duncan AE, Yared JP, Hesler BD, You J, Deogaonkar A, Sessler DI, Kurz A | Anesthesiology | 2015 |
Aged, Aged, 80 and over, Blood Glucose, analysis, Cardiac Surgical Procedures, adverse effects, Confusion, psychology, Delirium, chemically induced, Double-Blind Method, Female, Glucose Clamp Technique, Humans, Hyperinsulinism, blood, Intraoperative Care, adverse effects, Male, Middle Aged, Neuropsychological Tests, Postoperative Complications, chemically induced |
| Association between pre-hospital vitamin D status and hospital-acquired new-onset delirium. | Quraishi SA, Litonjua AA, Elias KM, Gibbons FK, Giovannucci E, Camargo CA, Christopher KB | The British journal of nutrition | 2015 | |
| Effect Estimation of an Innovative Nursing Intervention to Improve Delirium among Home-Dwelling Older Adults: A Randomized Controlled Pilot Trial. | Verloo H, Goulet C, Morin D, von Gunten A | Dementia and geriatric cognitive disorders extra | 2015 | |
| Identifying phenomenological differences and recovery of cognitive and non-cognitive symptomatology among delirium superimposed upon dementia patients (DsD) versus those without dementia (DaD) in an acute geriatric care setting. | Chong E, Tay L, Chong MS | International psychogeriatrics / IPA | 2015 | |
| Health economic implications of perioperative delirium in older patients after surgery for a fragility hip fracture. | Zywiel MG, Hurley RT, Perruccio AV, Hancock-Howard RL, Coyte PC, Rampersaud YR | The Journal of bone and joint surgery. American volume | 2015 |
Aged, Aged, 80 and over, Case-Control Studies, Costs and Cost Analysis, Delirium, economics, Female, Fractures, Spontaneous, economics, Hip Fractures, economics, Humans, Length of Stay, economics, Male, Perioperative Care, economics, Postoperative Complications, economics, Propensity Score, Prospective Studies |
| The Bromhead Care Home Service: the impact of a service for care home residents with dementia on hospital admission and dying in preferred place of care. | Garden G, Green S, Pieniak S, Gladman J | Clinical medicine (London, England) | 2016 | |
| The Association Between Preoperative Frailty and Postoperative Delirium After Cardiac Surgery. | Brown CH, Max L, LaFlam A, Kirk L, Gross A, Arora R, Neufeld K, Hogue CW, Walston J, Pustavoitau A | Anesthesia and analgesia | 2016 | |
| Antipsychotic Drug Use and Screening for Delirium in Mechanically Ventilated Patients in Canadian Intensive Care Units: An Observational Study. | Thiboutot Z, Perreault MM, Williamson DR, Rose L, Mehta S, Guenette MD, Cook D, Burry L | The Canadian journal of hospital pharmacy | 2016 | |
| Abnormal Mini-Cog Is Associated with Higher Risk of Complications and Delirium in Geriatric Patients with Fracture. | Heng M, Eagen CE, Javedan H, Kodela J, Weaver MJ, Harris MB | The Journal of bone and joint surgery. American volume | 2016 | |
| DELirium Prediction Based on Hospital Information (Delphi) in General Surgery Patients. | Kim MY, Park UJ, Kim HT, Cho WH | Medicine | 2016 | |
| Serum Anticholinergic Activity and Cognitive and Functional Adverse Outcomes in Older People: A Systematic Review and Meta-Analysis of the Literature. | Salahudeen MS, Chyou TY, Nishtala PS | PloS one | 2016 | |
| Impact of length of red blood cells transfusion on postoperative delirium in elderly patients undergoing hip fracture surgery: A cohort study. | Zhang ZY, Gao DP, Yang JJ, Sun XR, Zhang H, Hu J, Fang ZY, Yang JJ, Ji MH | Injury | 2016 | |
| Nursing intervention versus usual care to improve delirium among home-dwelling older adults receiving homecare after hospitalization: feasibility and acceptability of a Randomized Controlled Trail. | Verloo H, Goulet C, Morin D, von Gunten A | BMC nursing | 2016 | |
| Use of medications that antagonize mediators of inflammatory responses may reduce the risk of delirium in older adults: a nested case-control study. | Cole MG, McCusker J, Wilchesky M, Voyer P, Monette J, Champoux N, Vu M, Ciampi A, Belzile E | International journal of geriatric psychiatry | 2016 | |
| Frequency of full, partial and no recovery from subsyndromal deliriumin older hospital inpatients. | Cole MG, Bailey R, Bonnycastle M, McCusker J, Fung S, Ciampi A, Belzile E | International journal of geriatric psychiatry | 2016 | |
| Preventing ICU Subsyndromal Delirium Conversion to Delirium With Low-Dose IV Haloperidol: A Double-Blind, Placebo-Controlled Pilot Study. | Al-Qadheeb NS, Skrobik Y, Schumaker G, Pacheco MN, Roberts RJ, Ruthazer RR, Devlin JW | Critical care medicine | 2016 | |
| Postoperative plasma 8-iso-prostaglandin F2α levels are associated with delirium and cognitive dysfunction in elderly patients after hip fracture surgery. | Zheng YB, Ruan GM, Fu JX, Su ZL, Cheng P, Lu JZ | Clinica chimica acta; international journal of clinical chemistry | 2016 | |
| Profiles of delirium and the clinical outcomes of patients who underwent coronary artery bypass grafting: a prospective study from China. | Zhang W, Hu W, Shen M, Ye X, Huang Y, Sun Y | Journal of clinical nursing | 2016 |
Adult, Aged, Aged, 80 and over, China, Coronary Artery Bypass, adverse effects, Coronary Artery Disease, psychology, Delirium, diagnosis, Female, Humans, Length of Stay, Male, Middle Aged, Outcome Assessment (Health Care), Prospective Studies |
| Risk factors for postoperative delirium following hip fracture repair in elderly patients: a systematic review and meta-analysis. | Yang Y, Zhao X, Dong T, Yang Z, Zhang Q, Zhang Y | Aging clinical and experimental research | 2017 | |
| RADAR: A Measure of the Sixth Vital Sign? | Voyer P, Champoux N, Desrosiers J, Landreville P, McCusker J, Monette J, Savoie M, Carmichael PH, Richard H, Richard S | Clinical nursing research | 2016 | |
| Association between frailty and delirium in older adult patients discharged from hospital. | Verloo H, Goulet C, Morin D, von Gunten A | Clinical interventions in aging | 2016 | |
| Psychometric properties and feasibility of instruments for the detection of delirium in older hospitalized patients: a systematic review. | van Velthuijsen EL, Zwakhalen SM, Warnier RM, Mulder WJ, Verhey FR, Kempen GI | International journal of geriatric psychiatry | 2016 | |
| The patient's perception of a delirium: A qualitative research in a Belgian intensive care unit. | Van Rompaey B, Van Hoof A, van Bogaert P, Timmermans O, Dilles T | Intensive & critical care nursing : the official journal of the British Association of Critical Care Nurses | 2016 | |
| Biomarkers of Delirium in a Low-Risk Community-Acquired Pneumonia-Induced Sepsis. | Tomasi CD, Vuolo F, Generoso J, Soares M, Barichello T, Quevedo J, Ritter C, Dal-Pizzol F | Molecular neurobiology | 2016 | |
| How to advance prediction of postoperative delirium? A secondary analysis comparing three methods for very early assessment of elderly patients after surgery and early prediction of delirium. | Stukenberg S, Franck M, Spies CD, Neuner B, Myers I, Radtke FM | Minerva anestesiologica | 2016 | |
| A Flipped Classroom Approach to Improving the Quality of Delirium Care Using an Interprofessional Train-the-Trainer Program. | Sockalingam S, James SL, Sinyi R, Carroll A, Laidlaw J, Yanofsky R, Sheehan K | The Journal of continuing education in the health professions | 2016 | |
| Reduced Cerebral Perfusion Pressure during Lung Transplant Surgery Is Associated with Risk, Duration, and Severity of Postoperative Delirium. | Smith PJ, Blumenthal JA, Hoffman BM, Rivelli SK, Palmer SM, Davis RD, Mathew JP | Annals of the American Thoracic Society | 2016 | |
| Depressive Symptoms and Risk of Postoperative Delirium. | Smith PJ, Attix DK, Weldon BC, Monk TG | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2016 | |
| Dynamic light application therapy to reduce the incidence and duration of delirium in intensive-care patients: a randomised controlled trial. | Simons KS, Laheij RJ, van den Boogaard M, Moviat MA, Paling AJ, Polderman FN, Rozendaal FW, Salet GA, van der Hoeven JG, Pickkers P, de Jager CP | The Lancet. Respiratory medicine | 2016 | |
| Interventions for preventing delirium in hospitalised non-ICU patients. | Siddiqi N, Harrison JK, Clegg A, Teale EA, Young J, Taylor J, Simpkins SA | The Cochrane database of systematic reviews | 2016 | |
| Validation of the Sour Seven Questionnaire for screening delirium in hospitalized seniors by informal caregivers and untrained nurses. | Shulman RW, Kalra S, Jiang JZ | BMC geriatrics | 2016 |
Aged, Aged, 80 and over, Caregivers, psychology, Delirium, diagnosis, Family, psychology, Female, Geriatric Assessment, methods, Hospitalization, Humans, Male, Mass Screening, methods, Nurse’s Role, psychology, Pilot Projects, Surveys and Questionnaires, standards |
| Efficacy and safety of haloperidol for in-hospital delirium prevention and treatment: A systematic review of current evidence. | Schrijver EJ, de Graaf K, de Vries OJ, Maier AB, Nanayakkara PW | European journal of internal medicine | 2016 | |
| Systematic review and meta-analysis of risk factors for postoperative delirium among older patients undergoing gastrointestinal surgery. | Scholz AF, Oldroyd C, McCarthy K, Quinn TJ, Hewitt J | The British journal of surgery | 2016 | |
| Validation of a Delirium Risk Assessment Using Electronic Medical Record Information. | Rudolph JL, Doherty K, Kelly B, Driver JA, Archambault E | Journal of the American Medical Directors Association | 2016 | |
| The implementation of a nonpharmacologic protocol to prevent intensive care delirium. | Rivosecchi RM, Kane-Gill SL, Svec S, Campbell S, Smithburger PL | Journal of critical care | 2016 | |
| Delirium superimposed on dementia: a survey of delirium specialists shows a lack of consensus in clinical practice and research studies. | Richardson S, Teodorczuk A, Bellelli G, Davis DH, Neufeld KJ, Kamholz BA, Trabucchi M, MacLullich AM, Morandi A | International psychogeriatrics / IPA | 2016 | |
| Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial. | Reade MC, Eastwood GM, Bellomo R, Bailey M, Bersten A, Cheung B, Davies A, Delaney A, Ghosh A, van Haren F, Harley N, Knight D, McGuiness S, Mulder J, O'Donoghue S, Simpson N, Young P, , | JAMA | 2016 |
Aged, Australia, Delirium, complications, Dexmedetomidine, administration & dosage, Double-Blind Method, Female, Humans, Hypnotics and Sedatives, administration & dosage, Male, Middle Aged, New Zealand, Proportional Hazards Models, Psychomotor Agitation, drug therapy, Respiration, Artificial, statistics & numerical data, Time Factors, Treatment Outcome, Ventilator Weaning, contraindications |
| Functional interrelationship of brain aging and delirium. | Rapazzini P | Aging clinical and experimental research | 2016 | |
| Delirium risk stratification in consecutive unselected admissions to acute medicine: validation of externally derived risk scores. | Pendlebury ST, Lovett N, Smith SC, Cornish E, Mehta Z, Rothwell PM | Age and ageing | 2016 | |
| A Family-Focused Delirium Educational Initiative With Practice and Research Implications. | Paulson CM, Monroe T, McDougall GJ, Fick DM | Gerontology & geriatrics education | 2016 | |
| How do doctors and nurses manage delirium in intensive care units? A qualitative study using focus groups. | Palacios-Ceña D, Cachón-Pérez JM, Martínez-Piedrola R, Gueita-Rodriguez J, Perez-de-Heredia M, Fernández-de-Las-Peñas C | BMJ open | 2016 | |
| The role of anesthesia in the prevention of postoperative delirium: a systematic review. | Orena EF, King AB, Hughes CG | Minerva anestesiologica | 2016 | |
| Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery in the Sugammadex Era: A Retrospective Study. | Oh CS, Rhee KY, Yoon TG, Woo NS, Hong SW, Kim SH | BioMed research international | 2016 | |
| High prolactin levels are associated with more delirium in septic patients. | Nguyen DN, Huyghens L, Schiettecatte J, Smitz J, Vincent JL | Journal of critical care | 2016 | |
| Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta-Analysis. | Neufeld KJ, Yue J, Robinson TN, Inouye SK, Needham DM | Journal of the American Geriatrics Society | 2016 | |
| Depressive Symptoms Before, During, and After Delirium: A Literature Review. | Nelson S, Rustad JK, Catalano G, Stern TA, Kozel FA | Psychosomatics | 2016 | |
| Rosuvastatin versus placebo for delirium in intensive care and subsequent cognitive impairment in patients with sepsis-associated acute respiratory distress syndrome: an ancillary study to a randomised controlled trial. | Needham DM, Colantuoni E, Dinglas VD, Hough CL, Wozniak AW, Jackson JC, Morris PE, Mendez-Tellez PA, Ely EW, Hopkins RO | The Lancet. Respiratory medicine | 2016 | |
| Cyproheptadine for the Prevention of Postoperative Delirium: A Pilot Study. | Mohammadi M, Ahmadi M, Khalili H, Cheraghchi H, Arbabi M | The Annals of pharmacotherapy | 2016 | |
| Delirium after surgical and transcatheter aortic valve replacement is associated with increased mortality. | Maniar HS, Lindman BR, Escallier K, Avidan M, Novak E, Melby SJ, Damiano MS, Lasala J, Quader N, Rao RS, Lawton J, Moon MR, Helsten D, Pasque MK, Damiano RJ, Zajarias A | The Journal of thoracic and cardiovascular surgery | 2016 | |
| The Efficacy of Earplugs as a Sleep Hygiene Strategy for Reducing Delirium in the ICU: A Systematic Review and Meta-Analysis. | Litton E, Carnegie V, Elliott R, Webb SA | Critical care medicine | 2016 | |
| Delirium in critical care: a study of incidence, prevalence, and associated factors in the tertiary care hospital of older Thai adults. | Limpawattana P, Panitchote A, Tangvoraphonkchai K, Suebsoh N, Eamma W, Chanthonglarng B, Tiamkao S | Aging & mental health | 2016 | |
| Comparison of cognitive and neuropsychiatric profiles in hospitalised elderly medical patients with delirium, dementia and comorbid delirium-dementia. | Leonard M, McInerney S, McFarland J, Condon C, Awan F, O'Connor M, Reynolds P, Meaney AM, Adamis D, Dunne C, Cullen W, Trzepacz PT, Meagher DJ | BMJ open | 2016 | |
| Identification of sub-groups in acutely ill elderly patients with delirium: a cluster analysis. | Lagarto L, Cerejeira J | International psychogeriatrics / IPA | 2016 | |
| Development and validation of the Thai version of the 4 'A's Test for delirium screening in hospitalized elderly patients with acute medical illnesses. | Kuladee S, Prachason T | Neuropsychiatric disease and treatment | 2016 | |
| Delirium is a risk factor for further cognitive decline in cognitively impaired hip fracture patients. | Krogseth M, Watne LO, Juliebø V, Skovlund E, Engedal K, Frihagen F, Wyller TB | Archives of gerontology and geriatrics | 2016 |