What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords | |
|---|---|---|---|---|---|
| DEL-FINE: a new tool for assessing the delirogenic properties of drugs of relevance for European pharmacotherapy. | Böhmdorfer B, Rohleder S, Wawruch M, van der Cammen TJ, Frühwald T, Jagsch C, Janowitz SM, Nagano M, Petrovic M, Sommeregger U, Iglseder B | Zeitschrift fur Gerontologie und Geriatrie | 2016 |
Anticholinergic Syndrome, etiology, Delirium, chemically induced, Delphi Technique, Drug Therapy, standards, Europe, Expert Testimony, methods, Humans, Practice Guidelines as Topic |
|
| Consciousness, Functional networks and Delirium screening. | Eeles E, Burianova H, Pandy S, Pinsker D | Current aging science | 2016 | ||
| Delirium: A Survey of Healthcare Professionals' Knowledge, Beliefs, and Practices. | Sinvani L, Kozikowski A, Pekmezaris R, Akerman M, Wolf-Klein G | Journal of the American Geriatrics Society | 2016 | ||
| Low dose dexmedetomidine for the prophylaxis of perioperative ICU delirium-how much evidence is enough? | Reade MC | Journal of thoracic disease | 2016 | ||
| [Study of prevention and control of delirium in ventilated patients by simulating blockage of circadian rhythm with sedative in intensive care unit]. | Li J, Dong C, Zhang H, Zhang H, Song R, Yang Z, Feng F, Qi Y, Yang J | Zhonghua wei zhong bing ji jiu yi xue | 2016 |
Analgesics, Circadian Rhythm, Critical Care, Delirium, Dexmedetomidine, Fentanyl, Humans, Hypnotics and Sedatives, Intensive Care Units, Pain, Propofol, Prospective Studies, Respiration, Artificial |
|
| Effect of Cognitively Stimulating Activities on Symptom Management of Delirium Superimposed on Dementia: A Randomized Controlled Trial. | Kolanowski A, Fick D, Litaker M, Mulhall P, Clare L, Hill N, Mogle J, Boustani M, Gill D, Yevchak-Sillner A | Journal of the American Geriatrics Society | 2016 | ||
| Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery. | Karren EA, King AB, Hughes CG | Journal of thoracic disease | 2016 | ||
| Decreased Incidence of Postoperative Delirium in Robot-assisted Thoracoscopic Esophagectomy Compared With Open Transthoracic Esophagectomy. | Jeong DM, Kim JA, Ahn HJ, Yang M, Heo BY, Lee SH | Surgical laparoscopy, endoscopy & percutaneous techniques | 2016 | ||
| Delirium in the Neuro Intensive Care Unit. | Haymore JB, Patel N | Critical care nursing clinics of North America | 2016 |
Brief Psychiatric Rating Scale, Critical Care, Delirium, physiopathology, Humans, Intensive Care Units, Nursing Assessment, Pain Management |
|
| CE: Assessing and Managing Pain, Agitation, and Delirium in Hospitalized Older Adults. | Hartjes TM, Meece L, Horgas AL | The American journal of nursing | 2016 |
Aged, Delirium, diagnosis, Education, Continuing, Hospitalization, Humans, Pain Management, methods, Pain Measurement, methods, Psychomotor Agitation, diagnosis |
|
| The Search for Effective Delirium Treatment for Persons with Dementia in the Postacute-Care Setting. | Fong TG, Albuquerque A, Inouye SK | Journal of the American Geriatrics Society | 2016 | ||
| Postoperative Delirium After Liver Transplantation is Associated With Increased Length of Stay and Lower Survival in a Prospective Cohort. | Beckmann S, Schubert M, Burkhalter H, Dutkowski P, De Geest S | Progress in transplantation (Aliso Viejo, Calif.) | 2016 | ||
| Predicting Delirium in Older Patients Hospitalized for Community-Acquired Pneumonia. | Viscogliosi G, Chiriac IM, Braucci S, Terracina D, Andreozzi P, Ettorre E | Journal of the American Medical Directors Association | 2016 | ||
| Preoperative discussion with patients about delirium risk: are we doing enough? | Tomlinson JH, Partridge JS | Perioperative medicine (London, England) | 2016 | ||
| Development, Implementation, and Outcomes of a Delirium Protocol in the Surgical Trauma Intensive Care Unit. | Sullinger D, Gilmer A, Jurado L, Zimmerman LH, Steelman J, Gallagher A, Dupre T, Acquista E | The Annals of pharmacotherapy | 2016 | ||
| The role of the NADPH oxidase derived brain oxidative stress in the cocaine-related death associated with excited delirium: A literature review. | Schiavone S, Neri M, Mhillaj E, Pomara C, Trabace L, Turillazzi E | Toxicology letters | 2016 | ||
| Does this patient have delirium? | Salluh JI, Sharshar T, Kress JP | Intensive care medicine | 2016 | ||
| [Knowledge and implementation of the S3 guideline on delirium management in Germany]. | Saller T, V Dossow V, Hofmann-Kiefer K | Der Anaesthesist | 2016 | ||
| Arousal, Attention, and an Abundance of Opportunity to Advance Delirium Care. | Rudolph JL | Journal of the American Medical Directors Association | 2016 | ||
| Risk factors of post-operative delirium after elective vascular surgery in the elderly: A systematic review. | Raats JW, Steunenberg SL, de Lange DC, van der Laan L | International journal of surgery (London, England) | 2016 | ||
| Screening for delirium in specialist palliative care inpatient units: perceptions and outcomes. | Porteous A, Dewhurst F, Gray WK, Coulter P, Karandikar U, Kiltie R, Lowery L, MacCormick F, Paxton A, Pickard J, Rowley G, Vidrine J, Walmsley R, Waterfield K, Weiand D, Grogan E | International journal of palliative nursing | 2016 | ||
| Postoperative delirium: age and low functional reserve as independent risk factors. | Pinho C, Cruz S, Santos A, Abelha FJ | Journal of clinical anesthesia | 2016 | ||
| Delirium assessment in intensive care units: practices and perceptions of Turkish nurses. | Özsaban A, Acaroglu R | Nursing in critical care | 2016 | ||
| Nurses' and physicians' perceptions of Confusion Assessment Method for the intensive care unit for delirium detection: focus group study. | Oxenbøll-Collet M, Egerod I, Christensen V, Jensen J, Thomsen T | Nursing in critical care | 2016 | ||
| Post-anaesthetic emergence delirium in adults: incidence, predictors and consequences. | Munk L, Andersen G, Møller AM | Acta anaesthesiologica Scandinavica | 2016 | ||
| The Diagnosis of Delirium Superimposed on Dementia: An Emerging Challenge. | Morandi A, Davis D, Bellelli G, Arora RC, Caplan GA, Kamholz B, Kolanowski A, Fick DM, Kreisel S, MacLullich A, Meagher D, Neufeld K, Pandharipande PP, Richardson S, Slooter AJ, Taylor JP, Thomas C, Tieges Z, Teodorczuk A, Voyer P, Rudolph JL | Journal of the American Medical Directors Association | 2017 | ||
| Revisiting DLB Diagnosis: A Consideration of Prodromal DLB and of the Diagnostic Overlap With Alzheimer Disease. | McKeith I, Taylor JP, Thomas A, Donaghy P, Kane J | Journal of geriatric psychiatry and neurology | 2016 | ||
| Underreporting of Delirium in Statewide Claims Data: Implications for Clinical Care and Predictive Modeling. | McCoy TH, Snapper L, Stern TA, Perlis RH | Psychosomatics | 2016 | ||
| [Delusion versus delirium]. | Martínez-Velilla N, Franco JG, Molina Amaya CM | Medicina clínica | 2016 | ||
| [The recognition and diagnosis of delirium in elderly people in intensive care unit]. | Li QD, Wan XY | Zhonghua nei ke za zhi | 2016 | ||
| Cancer patients with delirium in the emergency department: A frequent and distressing problem that calls for better assessment. | Lawlor PG | Cancer | 2016 | ||
| Routine use of antipsychotics to prevent or treat delirium is not recommended. | Kishi T | Evidence-based mental health | 2016 | ||
| Preoperative Cognitive Performance Dominates Risk for Delirium Among Older Adults. | Jones RN, Marcantonio ER, Saczynski JS, Tommet D, Gross AL, Travison TG, Alsop DC, Schmitt EM, Fong TG, Cizginer S, Shafi MM, Pascual-Leone A, Inouye SK | Journal of geriatric psychiatry and neurology | 2016 | ||
| Total intravenous anesthesia with propofol is associated with a lower rate of postoperative delirium in comparison with sevoflurane anesthesia in elderly patients. | Ishii K, Makita T, Yamashita H, Matsunaga S, Akiyama D, Toba K, Hara K, Sumikawa K, Hara T | Journal of clinical anesthesia | 2016 | ||
| Preclinical Amyloid-β and Axonal Degeneration Pathology in Delirium. | Idland AV, Wyller TB, Støen R, Eri LM, Frihagen F, Ræder J, Chaudhry FA, Hansson O, Zetterberg H, Blennow K, Bogdanovic N, Brækhus A, Watne LO | Journal of Alzheimer's disease : JAD | 2016 | ||
| The Mystery of Delirium. Could Biomarkers of Endothelial Activation Reveal the Secrets? | Frendl G | Critical care medicine | 2016 | ||
| A Simple Tool to Predict Development of Delirium After Elective Surgery. | Dworkin A, Lee DS, An AR, Goodlin SJ | Journal of the American Geriatrics Society | 2016 | ||
| Cardiovascular surgery nurses' level of knowledge regarding delirium. | Demir Korkmaz F, Gok F, Yavuz Karamanoglu A | Nursing in critical care | 2016 | ||
| Poster 30 Use of Delirium Triggering Medications Among Patients with Delirium at Admission to Inpatient Rehabilitation Facility. | Dabaghian L, Yonclas PP, Seidel B, Jasey NN, Oh-Park M | PM & R : the journal of injury, function, and rehabilitation | 2016 | ||
| Comparison of pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a protocol for a systematic review incorporating network meta-analyses. | Burry LD, Hutton B, Guenette M, Williamson D, Mehta S, Egerod I, Kanji S, Adhikari NK, Moher D, Martin CM, Rose L | Systematic reviews | 2016 | ||
| Unraveling the Relationship Between Delirium, Brain Damage, and Subsequent Cognitive Decline in a Cohort of Individuals Undergoing Surgery for Hip Fracture. | Beishuizen SJ, Scholtens RM, van Munster BC, de Rooij SE | Journal of the American Geriatrics Society | 2016 | ||
| Standardizing Management of Adults with Delirium Hospitalized on Medical-Surgical Units. | Angel C, Brooks K, Fourie J | The Permanente journal | 2016 | ||
| The utility of the clock drawing test in detection of delirium in elderly hospitalised patients. | Adamis D, Meagher D, O'Neill D, McCarthy G | Aging & mental health | 2016 | ||
| Effect of New Cerebral Ischemic Lesions on the Delirium Occurrence After Transcatheter Aortic Valve Replacement. | Abawi M, Nijhoff F, Agostoni P, de Vries R, Slooter AJ, Emmelot-Vonk MH, Voskuil M, Leiner T, Doevendans PA, Stella PR | Journal of the American College of Cardiology | 2016 | ||
| Is cobalamin deficiency associated with increased risk of all subtypes of postoperative delirium? | Wang LK, Lan KM, Lin YT, Chen JY | Neuropsychiatric disease and treatment | 2016 | ||
| Meeting the Challenges of Delirium Assessment Across the Aging Spectrum. | Smith HA, Han JH, Ely EW | Critical care medicine | 2016 | ||
| Response to Paul Regal. | Schmitt EM, Inouye SK | Journal of the American Geriatrics Society | 2016 | ||
| Is delirium the medical emergency we know least about? | Nagaraj G, Burkett E, Hullick C, Carpenter CR, Arendts G | Emergency medicine Australasia : EMA | 2016 | ||
| Earplugs might reduce intensive care unit delirium but quality of evidence is low. | Law AC, Walkey AJ | Evidence-based medicine | 2016 | ||
| The major risk factors for delirium in a clinical setting. | Kim H, Chung S, Joo YH, Lee JS | Neuropsychiatric disease and treatment | 2016 | ||
| Prevalence, determinants, and prognostic significance of delirium in patients with acute heart failure. | Honda S, Nagai T, Sugano Y, Okada A, Asaumi Y, Aiba T, Noguchi T, Kusano K, Ogawa H, Yasuda S, Anzai T, | International journal of cardiology | 2016 | ||
| Delirium in older adults: a chronic cognitive disorder? | Cole MG, Mccusker J | International psychogeriatrics / IPA | 2016 | ||
| Sedative choice and ventilator-associated patient outcomes: don't sleep on delirium. | Barnes SS, Kudchadkar SR | Annals of translational medicine | 2016 | ||
| The use of volunteers to help older medical patients mobilise in hospital: a systematic review. | Baczynska AM, Lim SE, Sayer AA, Roberts HC | Journal of clinical nursing | 2016 | ||
| The Geriatric Day Hospital: Preliminary Data on an Innovative Model of Care in Brazil for Older Adults at Risk of Hospitalization. | Aliberti MJ, Suemoto CK, Fortes-Filho SQ, Melo JA, Trindade CB, Kasai JY, Altona M, Apolinario D, Jacob-Filho W | Journal of the American Geriatrics Society | 2016 | ||
| Long-Term Mental Health Problems After Delirium in the ICU. | Wolters AE, Peelen LM, Welling MC, Kok L, de Lange DW, Cremer OL, van Dijk D, Slooter AJ, Veldhuijzen DS | Critical care medicine | 2016 | ||
| Delirium assessment in hospitalized elderly patients: Italian translation and validation of the nursing delirium screening scale. | Spedale V, Di Mauro S, Del Giorno G, Barilaro M, Villa CE, Gaudreau JD, Ausili D | Aging clinical and experimental research | 2016 | ||
| Insulin-like growth factor-1, a potential predicative biomarker for postoperative delirium among elderly patients with open abdominal surgery. | Shen H, Shao Y, Chen J, Guo J | Current pharmaceutical design | 2016 | ||
| Delirium the under-recognised syndrome: survey of healthcare professionals' awareness and practice in the intensive care units. | Selim AA, Wesley Ely E | Journal of clinical nursing | 2017 |
Adult, Attitude of Health Personnel, Critical Care, organization & administration, Cross-Sectional Studies, Delirium, diagnosis, Disease Management, Egypt, Female, Health Care Surveys, Health Knowledge, Attitudes, Practice, Health Personnel, psychology, Humans, Intensive Care Units, organization & administration, Male, Middle Aged, Nursing Staff, Hospital, psychology, Physicians, psychology, Surveys and Questionnaires |
|
| Intra-operative events during cardiac surgery are risk factors for the development of delirium in the ICU. | Rudiger A, Begdeda H, Babic D, Krüger B, Seifert B, Schubert M, Spahn DR, Bettex D | Critical care (London, England) | 2016 | ||
| Validity and Reliability of the 6-Item Cognitive Impairment Test for Screening Cognitive Impairment: A Review. | O'Sullivan D, O'Regan NA, Timmons S | Dementia and geriatric cognitive disorders | 2016 | ||
| Delirium in elderly patients: association with educational attainment. | Martins S, Paiva JA, Simões MR, Fernandes L | Acta neuropsychiatrica | 2017 |
Aged, Aged, 80 and over, Cognitive Reserve, Delirium, epidemiology, Educational Status, Female, Glasgow Coma Scale, Humans, Male, Portugal, epidemiology, Psychiatric Status Rating Scales |
|
| Prevalence of Delirium in Older Medical Inpatients in Tanzania. | Lewis E, Paddick SM, Banks J, Duinmaijer A, Tucker L, Kisoli A, Cletus J, Lissu C, Dotchin C, Gray W, Walker R, Urasa S | Journal of the American Geriatrics Society | 2016 | ||
| Preventing postoperative delirium: all that glisters is not gold. | Kronzer VL, Avidan MS | Lancet (London, England) | 2016 | ||
| Trajectory of Functional Recovery After Postoperative Delirium in Elective Surgery. | Hshieh TT, Saczynski J, Gou RY, Marcantonio E, Jones RN, Schmitt E, Cooper Z, Ayres D, Wright J, Travison TG, Inouye SK, | Annals of surgery | 2017 | ||
| Evaluation of delirium screening tools in geriatric medical inpatients: a diagnostic test accuracy study. | Hendry K, Quinn TJ, Evans J, Scortichini V, Miller H, Burns J, Cunnington A, Stott DJ | Age and ageing | 2016 | ||
| Mind Over Matter? The Hidden Epidemic of Cognitive Dysfunction in the Older Surgical Patient. | O' Brien H, Mohan H, Hare CO, Reynolds JV, Kenny RA | Annals of surgery | 2016 | ||
| The Impact of Interventions to Improve Sleep on Delirium in the ICU: A Systematic Review and Research Framework. | Flannery AH, Oyler DR, Weinhouse GL | Critical care medicine | 2016 | ||
| Neuroinflammatory challenges compromise neuronal function in the aging brain: Postoperative cognitive delirium and Alzheimer's disease. | Cortese GP, Burger C | Behavioural brain research | 2016 | ||
| Delirium: Time to climb this babylon tower. | Capponi MG, Biffi AM, Spada MS, Ansaloni L | European journal of internal medicine | 2017 | ||
| Preventing delirium: beyond dexmedetomidine. | Avramescu S, Wang DS, Choi S, Orser BA | Lancet (London, England) | 2017 | ||
| Prevalence and Risk Factors for Delirium in Acute Stroke Patients. A Retrospective 5-Years Clinical Series. | Alvarez-Perez FJ, Paiva F | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association | 2017 | ||
| An evolving approach to delirium: A mixed-methods process evaluation of a hospital-wide delirium program in New Zealand. | Alhaidari AA, Allen-Narker RA | Australasian journal on ageing | 2017 | ||
| Delirium superimposed on dementia: phenomenological differences between patients with and without behavioral and psychological symptoms of dementia in a specialized delirium unit. | Abengaña J, Chong MS, Tay L | International psychogeriatrics | 2017 | ||
| Incidence, risk factors and outcomes of delirium in intensive care unit of universiti kebangsaan malaysia medical centre | Vyveganathan, L., Izaham, A., Mohamad Yusof, A., Wan Mat, W. R., Abdul Rahman, R., Abdul Manap, N. | Anesthesia and Analgesia | 2016 |
bilirubin |
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| Influence of acute delirium on short-term prognosis in elderly acute decompensated heart failure patients | Tagahara, K., Azioka, M., Nakashima, Y., Osanai, H., Inoue, Y., Kanbara, T., Yoshida, T., Masutomi, T., Ohashi, H., Tobe, A. | Journal of Cardiac Failure | 2016 |
acute heart failure |
|
| Implementing a delirium prevention programme can reduce falls in hospital geriatric medicine wards | Solomonsz, A., Charalambous, L., Taylor, R., Blackshaw, E., Ali, A., Morris, R., Moorchilot, R., Poon, M., Blundell, A., Harwood, R., Masud, T. | European Geriatric Medicine | 2016 | ||
| Emergence delirium in adult patients after general anaesthesia-a prospective study from the caribbean | Ramroop, R., Hariharan, S., Chen, D. | Anesthesia and Analgesia | 2016 |
atropine |
|
| Optimized anesthesia to reduce incidence of postoperative delirium in elderly undergoing elective, non-cardiac surgery: A randomized controlled trial | Punjasawadwong, Y., Pipanmekaporn, T., Wongpakaran, N. | Anesthesia and Analgesia | 2016 |
aged |
|
| Evaluation of the idea (identification and interventions for dementia in elderly Africans) brief cognitive screening tool for identification of delirium in older hospitalised adults in Tanzania | Paddick, S. M., Lewis, E. G., Duinmaijer, A. T., Banks, J., Urasa, S., Tucker, L., Kisoli, A., Cletus, J., Lissu, C., Kisima, J., Dotchin, C., Gray, W. K., Mushi, D., Walker, R. | Alzheimer's and Dementia | 2016 |
adult |
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| Effectiveness of Educational Enhancement for Clinicians Regarding Understanding and Applying Confusion Assessment Method in the ICU (CAM-ICU) | Pandya, T., Hanna, M., Ghazarian, Z., Sekhon, R., Ismail, M. | CHEST | 2016 | ||
| Improving the detection of delirium, depression and suspected dementia in community hospital settings | North, C., Russell, G., Hayes, N. | European Geriatric Medicine | 2016 |
community hospital |
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| 127 Emergency Department Interventions and Their Effect on Delirium's Natural Course: The Folly May Be in the Foley | Noel, C., Cirbus, J., Han, J.H. | Annals of Emergency Medicine | 2016 |
Delirium Geriatrics Psychiatry |
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| Identifying and managing delirium on admission | Musaddaq, B., Bakshi, P., Roseman, H., Pleming, J., Saber, S., Wu, A., Mizoguchi, R. | European Geriatric Medicine | 2016 |
aged |
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| Association between mini nutritional assessment (MNA) and the development of delirium in elderly patients with hip fracture | Lozano-Montoya, I., Miret-Corchado, C., Vaquero-Pinto, M. N., Roldán-Plaza, C., Sánchez-García, E., Cruz-Jentoft, A. | European Geriatric Medicine | 2016 |
aged |
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| Comparison between cerebrolysin and citicoline in the incidence of postoperative delirium in adult cardiac surgical patients | Lespron, M. D. C., Morales, O., Molina, F. J., Figueroa, J., Suárez, L., Molina, A., Guerrero, R., Alvarez, H., Telona, E. J. | Anesthesia and Analgesia | 2016 |
cerebrolysin |
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| A comparison between confusion assessment method in intensive care unit (CAM-ICU) and neelon-champagne (NEECHAM) confusion scale | Karci, O., Serin, S., Sungurtekin, H. | 2016 |
adult |
||
| Promoting Sleep to Improve Delirium in the ICU∗ | Kamdar, B. B., Martin, J. L., Needham, D. M., Ong, M. K. | Critical Care Medicine | 2016 |
critical illness |
|
| Delirium as a non-traumatic brain injury: Older patients with delirium have similar biomarker profiles to patients with isolated traumatic brain injury | Jackson, T. A., Shears, B., Lord, J. M., Belli, A., Hazeldine, J. | European Geriatric Medicine | 2016 |
biological marker |
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| Comprehensive geriatric assessment for prevention of delirium post hip fracture: A systematic review of randomised controlled trials | Henderson, V., Shields, L., Clasake, R. | European Geriatric Medicine | 2016 |
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| Long-term prognostic value of DELIRIUM in elderly patients with acute Cardiac diseases admitted to two cardiac intensive care unit: A prospective study | Grotti, S., Falsini, G., Porto, I., Toccafondi, G., Fraticelli, A., Angioli, P., Ducci, K., Liistro, F., Pieroni, M., Taddei, T., Romanelli, S., Rossie, R., Bolognese, L. | European Heart Journal: Acute Cardiovascular Care | 2016 |
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| Hospitalised older people with dementia and delirium: More readmissions and in-hospital complications, greater length of stay and associated healthcare costs | Giudice, D. L., Tropea, J., Brand, C.A., Gorelik, A. Liew, D. | Alzheimer's and Dementia | 2016 |
Australia |
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| Progressive brain atrophy and cognitive decline along with multiple episodes of delirium. | Hayakawa K, Kato TA, Imamura S, Kasai N, Kanba S | Psychiatry and clinical neurosciences | 2017 | ||
| Case of insulinoma manifesting as hyperinsulinemia after discontinuing quetiapine in an elderly patient with delirium. | Yamamoto N, Oh E, Nishiyama K, Yoshida M, Saeki A, Ishii H, Takeda Y, Hamahata T, Sugino M | Geriatrics & gerontology international | 2017 | ||
| A National Multicenter Survey on Management of Pain, Agitation, and Delirium in Intensive Care Units in China. | Wang J, Peng ZY, Zhou WH, Hu B, Rao X, Li JG | Chinese medical journal | 2017 | ||
| High C-Reactive Protein Predicts Delirium Incidence, Duration, and Feature Severity After Major Noncardiac Surgery. | Vasunilashorn SM, Dillon ST, Inouye SK, Ngo LH, Fong TG, Jones RN, Travison TG, Schmitt EM, Alsop DC, Freedman SD, Arnold SE, Metzger ED, Libermann TA, Marcantonio ER | Journal of the American Geriatrics Society | 2017 | ||
| Interventions to Reduce Postoperative Delirium: Aligning Surgical Care With Patients' Needs and Priorities. | Suwanabol PA, Hinshaw DB | JAMA surgery | 2017 | ||
| Assessment of Delirium in Intensive Care Unit Patients: Educational Strategies. | Smith JM, Van Aman MN, Schneiderhahn ME, Edelman R, Ercole PM | Journal of continuing education in nursing | 2017 | ||
| Pathophysiological and behavioral effects of systemic inflammation in aged and diseased rodents with relevance to delirium: A systematic review. | Schreuder L, Eggen BJ, Biber K, Schoemaker RG, Laman JD, de Rooij SE | Brain, behavior, and immunity | 2017 | ||
| Effectiveness of haloperidol prophylaxis in critically ill patients with a high risk of delirium: a systematic review. | Santos E, Cardoso D, Neves H, Cunha M, Rodrigues M, Apóstolo J | JBI database of systematic reviews and implementation reports | 2017 |