What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
Title | Authors | Journal | Year | Keywords |
---|---|---|---|---|
Postoperative delirium after pharyngolaryngectomy with esophagectomy: a role for ramelteon and suvorexant. | Booka, E. Tsubosa, Y. Matsumoto, T. Takeuchi, M. Kitani, T. Nagaoka, M. Imai, A. Kamijo, T. Iida, Y. Shimada, A. Takebayashi, K. Niihara, M. Mori, K. Onitsuka, T. Takeuchi, H. Kitagawa, Y. | Esophagus | 2017 |
anxiolytic agent |
Pipamperone and delirium: A preliminary evaluation of its effectiveness in the management of delirium and its subtypes. | Boettger, S. Knoepfel, S. Schubert, M. Garcia Nuñez, D. Plichta, M. M. Klaghofer, R. Jenewein, J. | Swiss Medical Weekly | 2017 |
haloperidol |
Brief assessment of delirium subtypes: Psychometric evaluation of the Delirium Motor Subtype Scale (DMSS)-4 in the intensive care setting. | Boettger, Soenke Garcia NuÑEz, David Meyer, Rafael Richter, Andre Schubert, Maria Meagher, David Jenewein, Josef Nuñez, David Garcia | Palliative & Supportive Care | 2017 | |
Postoperative Delirium as a Target for Surgical Quality Improvement. | Berian, J. R. Zhou, L. Russell, M. M. Hornor, M. A. Cohen, M. E. Finlayson, E. Ko, C. Y. Rosenthal, R. A. Robinson, T. N. | Ann Surg | 2017 | |
The association between delirium and sarcopenia in older adult patients admitted to acute geriatrics units: Results from the GLISTEN multicenter observational study. | Bellelli, G. Zambon, A. Volpato, S. Abete, P. Bianchi, L. Bo, M. Cherubini, A. Corica, F. Di Bari, M. Maggio, M. Manca, G. M. Rizzo, M. R. Rossi, A. Landi, F. | Clin Nutr | 2017 |
Body mass index |
Distinct Cognitive Trajectories in the First Year After Hip Fracture. | Beishuizen, S. J. E. van Munster, B. C. de Jonghe, A. Abu-Hanna, A. Buurman, B. M. de Rooij, S. E. | Journal of the American Geriatrics Society | 2017 |
aged |
A quality improvement approach to cognitive assessment on hospice admission: could we use the 4AT or Short CAM? | Baird, L. Spiller, J. A. | BMJ Open Qual | 2017 |
Pdsa |
Incidence of Postoperative Delirium and Its Impact on Outcomes After Transcatheter Aortic Valve Implantation. | Bagienski, M. Kleczynski, P. Dziewierz, A. Rzeszutko, L. Sorysz, D. Trebacz, J. Sobczynski, R. Tomala, M. Stapor, M. Dudek, D. | Am J Cardiol | 2017 |
Aged |
Rates of Delirium Diagnosis Do Not Improve with Emergency Risk Screening: Results of the Emergency Department Delirium Initiative Trial. | Arendts, G. Love, J. Nagree, Y. Bruce, D. Hare, M. Dey, I. | J Am Geriatr Soc | 2017 |
Aged |
A Comparison of the Severe Cognitive Impairment Rating Scale With the Mini-Mental State Examination and Delirium Rating Scale-Revised-98 for Delirium: A Cross-sectional Study. | Ahn, S. H. Choi, J. H. Im, C. S. Kim, T. S. Kim, J. L. | Psychosomatics | 2017 |
cognitive impairment |
Motor Disturbances in Elderly Medical Inpatients and Their Relationship to Delirium. | Adamis, D. McCarthy, G. O'Mahony, E. Meagher, D. | J Geriatr Psychiatry Neurol | 2017 |
cognition |
Predicting delirium: are we there yet? | Evered LA | British journal of anaesthesia | 2017 | |
Low brain tissue oxygenation contributes to the development of delirium in critically ill patients: A prospective observational study. | , , Wood MD, Maslove DM, Muscedere JG, Day AG, Gordon Boyd J | Journal of critical care | 2017 | |
Nurse awareness of patients who may have incident delirium. | Sander R | Nursing older people | 2017 | |
Implementing Nurse-Facilitated Person-Centered Care Approaches for Patients With Delirium Superimposed on Dementia in the Acute Care Setting. | Yevchak A, Fick DM, Kolanowski AM, McDowell J, Monroe T, LeViere A, Mion L | Journal of gerontological nursing | 2017 | |
Postoperative delirium in total joint arthroplasty patients. | Mahawer B, Suthar N | General hospital psychiatry | 2017 | |
Impact of frailty and residual subsyndromal delirium on 1-year functional recovery: A prospective cohort study. | Chew J, Lim WS, Chong MS, Ding YY, Tay L | Geriatrics & gerontology international | 2017 | |
Placebo might be superior to antipsychotics in management of delirium in the palliative care setting. | Boettger S, Jenewein J | Evidence-based medicine | 2017 | |
One-year mortality after hip fracture in older individuals: the effects of delirium and dementia. | Mitchell R, Harvey L, Brodaty H, Draper B, Close J | Archives of gerontology and geriatrics | 2017 | |
Postoperative Delirium in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting According to the Anesthetic Agent: A Retrospective Study. | Oh CS, Park S, Wan Hong S, Kang WS, Yoon TG, Kim SH | Journal of cardiothoracic and vascular anesthesia | 2017 | |
Statin and Its Association With Delirium in the Medical ICU. | Mather JF, Corradi JP, Waszynski C, Noyes A, Duan Y, Grady J, Dicks R | Critical care medicine | 2017 | |
The problem of delirium following transcatheter aortic valve replacement. | Orvin K, Kornowski R | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions | 2017 | |
The intensive care delirium research agenda: a multinational, interprofessional perspective. | Pandharipande PP, Ely EW, Arora RC, Balas MC, Boustani MA, La Calle GH, Cunningham C, Devlin JW, Elefante J, Han JH, MacLullich AM, Maldonado JR, Morandi A, Needham DM, Page VJ, Rose L, Salluh JIF, Sharshar T, Shehabi Y, Skrobik Y, Slooter AJC, Smith HAB | Intensive care medicine | 2017 | |
Delirium prevention in critically ill adults through an automated reorientation intervention - A pilot randomized controlled trial. | Munro CL, Cairns P, Ji M, Calero K, Anderson WM, Liang Z | Heart & lung : the journal of critical care | 2017 | |
Anticholinergic drug exposure is associated with delirium and postdischarge institutionalization in acutely ill hospitalized older patients. | Egberts A, van der Craats ST, van Wijk MD, Alkilabe S, van den Bemt PMLA, Mattace-Raso FUS | Pharmacology research & perspectives | 2017 | |
Acute Brain Failure: Pathophysiology, Diagnosis, Management, and Sequelae of Delirium. | Maldonado JR | Critical care clinics | 2017 | |
A retrospective analysis of the effectiveness of antipsychotics in the treatment of ICU delirium. | Weaver CB, Kane-Gill SL, Gunn SR, Kirisci L, Smithburger PL | Journal of critical care | 2017 | |
Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery: A Randomized Clinical Trial. | Deiner S, Luo X, Lin HM, Sessler DI, Saager L, Sieber FE, Lee HB, Sano M, , Jankowski C, Bergese SD, Candiotti K, Flaherty JH, Arora H, Shander A, Rock P | JAMA surgery | 2017 | |
Confusion Regarding Surgical Delirium-Is Dexmedetomidine the Answer? | Berian JR, Rosenthal RA, Robinson TN | JAMA surgery | 2017 | |
Yokukansan for the treatment of preoperative anxiety and postoperative delirium in colorectal cancer patients: a retrospective study. | Wada S, Inoguchi H, Hirayama T, Matsuoka YJ, Uchitomi Y, Ochiai H, Tsukamoto S, Shida D, Kanemitsu Y, Shimizu K | Japanese journal of clinical oncology | 2017 | |
Delirium screening in intensive care: A life saving opportunity. | Lamond E, Murray S, Gibson CE | Intensive & critical care nursing | 2017 | |
Methodologic considerations in the design and analysis of nested case-control studies: association between cytokines and postoperative delirium. | Ngo LH, Inouye SK, Jones RN, Travison TG, Libermann TA, Dillon ST, Kuchel GA, Vasunilashorn SM, Alsop DC, Marcantonio ER | BMC medical research methodology | 2017 | |
Risk factors for postoperative delirium in patients undergoing vascular surgery. | Galyfos GC, Geropapas GE, Sianou A, Sigala F, Filis K | Journal of vascular surgery | 2017 | |
Clinical Features Associated with Delirium Motor Subtypes in Older Inpatients: Results of a Multicenter Study. | Morandi A, Di Santo SG, Cherubini A, Mossello E, Meagher D, Mazzone A, Bianchetti A, Ferrara N, Ferrari A, Musicco M, Trabucchi M, Bellelli G, | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2017 | |
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial. | Avidan MS, Maybrier HR, Abdallah AB, Jacobsohn E, Vlisides PE, Pryor KO, Veselis RA, Grocott HP, Emmert DA, Rogers EM, Downey RJ, Yulico H, Noh GJ, Lee YH, Waszynski CM, Arya VK, Pagel PS, Hudetz JA, Muench MR, Fritz BA, Waberski W, Inouye SK, Mashour GA, | Lancet (London, England) | 2017 | |
Ketamine fails to prevent postoperative delirium. | Eisenach JC | Lancet (London, England) | 2017 | |
Association of White Matter Lesions, Cerebral Atrophy, Intracranial Extravascular Calcifications, and Ventricular-Communicating Hydrocephalus with Delirium Among Veterans. | Detweiler MB, Sherigar RM, Bader G, Sullivan K, Kenneth A, Kalafat N, Reddy P, Lutgens B | Southern medical journal | 2017 |
Aged, Atrophy, diagnostic imaging, Brain Diseases, complications, Calcinosis, complications, Case-Control Studies, Cerebellum, diagnostic imaging, Delirium, etiology, Female, Humans, Hydrocephalus, complications, Male, Middle Aged, Parietal Lobe, diagnostic imaging, Retrospective Studies, Tomography, X-Ray Computed, Veterans, White Matter, pathology |
The role of predictive coding in the pathogenesis of delirium. | FitzGerald JM | Medical hypotheses | 2017 | |
Detecting delirium superimposed on dementia: diagnostic accuracy of a simple combined arousal and attention testing procedure. | Richardson SJ, Davis DHJ, Bellelli G, Hasemann W, Meagher D, Kreisel SH, MacLullich AMJ, Cerejeira J, Morandi A | International psychogeriatrics | 2017 | |
Acetylcholinesterase and butyrylcholinesterase in cardiosurgical patients with postoperative delirium. | John M, Ely EW, Halfkann D, Schoen J, Sedemund-Adib B, Klotz S, Radtke F, Stehr S, Hueppe M | Journal of intensive care | 2017 | |
Performance of the modified Richmond Agitation Sedation Scale in identifying delirium in older emergency department patients. | Grossmann FF, Hasemann W, Kressig RW, Bingisser R, Nickel CH | The American journal of emergency medicine | 2017 | |
Hypoactive delirium. | Hosker C, Ward D | BMJ (Clinical research ed.) | 2017 | |
Parecoxib Supplementation to Morphine Analgesia Decreases Incidence of Delirium in Elderly Patients After Hip or Knee Replacement Surgery: A Randomized Controlled Trial. | Mu DL, Zhang DZ, Wang DX, Wang G, Li CJ, Meng ZT, Li YW, Liu C, Li XY | Anesthesia and analgesia | 2017 | |
Identifying delirium in older adults with pre-existing mental illness. | Bennett C | The Nurse practitioner | 2017 | |
Iatrogenic Withdrawal Syndrome or Undiagnosed Delirium? | Traube C, Silver G | Critical care medicine | 2017 | |
The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial. | Tanaka P, Goodman S, Sommer BR, Maloney W, Huddleston J, Lemmens HJ | Journal of clinical anesthesia | 2017 | |
Incidence of delirium in postoperative patients treated with total knee and hip arthroplasty. | Bosmak FS, Gibim PT, Guimarães S, Ammirati AL | Revista da Associacao Medica Brasileira (1992) | 2017 | |
Implementation of an ICU Bundle: An Interprofessional Quality Improvement Project to Enhance Delirium Management and Monitor Delirium Prevalence in a Single PICU. | Simone S, Edwards S, Lardieri A, Walker LK, Graciano AL, Kishk OA, Custer JW | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies | 2017 | |
Risk factors for postoperative delirium in patients undergoing major head and neck cancer surgery: a meta-analysis. | Zhu Y, Wang G, Liu S, Zhou S, Lian Y, Zhang C, Yang W | Japanese journal of clinical oncology | 2017 | |
A family intervention to reduce delirium in hospitalised ICU patients: A feasibility randomised controlled trial. | Mitchell ML, Kean S, Rattray JE, Hull AM, Davis C, Murfield JE, Aitken LM | Intensive & critical care nursing | 2017 | |
Advancing the Neurophysiological Understanding of Delirium. | Shafi MM, Santarnecchi E, Fong TG, Jones RN, Marcantonio ER, Pascual-Leone A, Inouye SK | Journal of the American Geriatrics Society | 2017 | |
CHERISH (collaboration for hospitalised elders reducing the impact of stays in hospital): protocol for a multi-site improvement program to reduce geriatric syndromes in older inpatients. | Mudge AM, Banks MD, Barnett AG, Blackberry I, Graves N, Green T, Harvey G, Hubbard RE, Inouye SK, Kurrle S, Lim K, McRae P, Peel NM, Suna J, Young AM | BMC geriatrics | 2017 |
Accidental Falls, prevention & control, Aged, Aged, 80 and over, Cooperative Behavior, Cost-Benefit Analysis, methods, Delirium, prevention & control, Feeding Behavior, physiology, Female, Hospitalization, trends, Humans, Inpatients, psychology, Length of Stay, trends, Male, Nutritional Status, physiology, Patient Discharge, trends, Pilot Projects, Quality of Life, psychology, Research Design, Syndrome, Walking, physiology |
Design considerations of a randomized controlled trial of sedation level during hip fracture repair surgery: a strategy to reduce the incidence of postoperative delirium in elderly patients. | Li T, Wieland LS, Oh E, Neufeld KJ, Wang NY, Dickersin K, Sieber FE | Clinical trials (London, England) | 2017 | |
Acute Kidney Injury as a Risk Factor for Delirium and Coma during Critical Illness. | Siew ED, Fissell WH, Tripp CM, Blume JD, Wilson MD, Clark AJ, Vincz AJ, Ely EW, Pandharipande PP, Girard TD | American journal of respiratory and critical care medicine | 2017 | |
Screening for postoperative delirium in patients with acute hip fracture: Assessment of predictive factors. | Koskderelioglu A, Onder O, Gucuyener M, Altay T, Kayali C, Gedizlioglu M | Geriatrics & gerontology international | 2017 | |
Blood transfusion strategy and risk of postoperative delirium in nursing homes residents with hip fracture. A post hoc analysis based on the TRIFE randomized controlled trial. | Blandfort S, Gregersen M, Borris LC, Damsgaard EM | Aging clinical and experimental research | 2017 | |
Delirium risk stratification in consecutive unselected admissions to acute medicine: validation of a susceptibility score based on factors identified externally in pooled data for use at entry to the acute care pathway. | Pendlebury ST, Lovett NG, Smith SC, Wharton R, Rothwell PM | Age and ageing | 2017 | |
Pain, Agitation, and Delirium Guidelines: Interprofessional Perspectives to Translate the Evidence. | Jablonski J, Gray J, Miano T, Redline G, Teufel H, Collins T, Pascual-Lopez J, Sylvia M, Martin ND | Dimensions of critical care nursing : DCCN | 2017 | |
Delirium in the acute phase after stroke: comparison between methods of detection. | Infante MT, Pardini M, Balestrino M, Finocchi C, Malfatto L, Bellelli G, Mancardi GL, Gandolfo C, Serrati C | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology | 2017 | |
Identification of patients with cancer with a high risk to develop delirium. | Neefjes, E. C. W. van der Vorst, Mjdl Verdegaal, Batt Beekman, A. T. F. Berkhof, J. Verheul, H. M. W. | Cancer Med | 2017 |
Cancer |
Perioperative prediction of agitated (hyperactive) delirium after cardiac surgery in adults - The development of a practical scorecard. | Mufti, H. N. Hirsch, G. M. | J Crit Care | 2017 |
Cabg |
Development and validation of an automated delirium risk assessment system (Auto-DelRAS) implemented in the electronic health record system. | Moon, K. J. Jin, Y. Jin, T. Lee, S. M. | Int J Nurs Stud | 2017 |
Auto-DelRAS |
Efficacy of Ramelteon for delirium after lung cancer surgery. | Miyata R, Omasa M, Fujimoto R, Ishikawa H, Aoki M | Interactive cardiovascular and thoracic surgery | 2016 |
indene derivative |
Risk Factors for Postoperative Delirium in Abdominal Surgery: A Proposal of a Postoperative Delirium Risk Score in Abdominal Surgery. | Miyagawa, Y. Yokoyama, Y. Fukuzawa, S. Fukata, S. Ando, M. Kawamura, T. Yamada, K. Nagino, M. | Digestive Surgery | 2017 |
serum albumin |
Long-term cognitive impairment and delirium in intensive care: A prospective cohort study. | Mitchell, M. L. Shum, D. H. K. Mihala, G. Murfield, J. E. Aitken, L. M. | Aust Crit Care | 2017 |
Cognition |
Prevalence of delirium in advanced cancer patients in home care and hospice and outcomes after 1 week of palliative care. | Mercadante, S. Masedu, F. Balzani, I. De Giovanni, D. Montanari, L. Pittureri, C. Berte, R. Russo, D. Ursini, L. Marinangeli, F. Aielli, F. | Support Care Cancer | 2017 |
Advanced cancer |
Characterizing and predicting rates of delirium across general hospital settings. | McCoy, Thomas H. Hart, Kamber L. Perlis, Roy H. | General Hospital Psychiatry | 2017 |
Delirium |
Environmental and Clinical Risk Factors for Delirium in a Neurosurgical Center: A Prospective Study. | Matano, F. Mizunari, T. Yamada, K. Kobayashi, S. Murai, Y. Morita, A. | World Neurosurg | 2017 |
Delirium |
Genetic and environmental factors associated with delirium severity in older adults with dementia | Massimo, Lauren Munoz, Elizabeth Hill, Nikki Mogle, Jacqueline Mulhall, Paula McMillan, Corey T. Clare, Linda Vandenbergh, David Fick, Donna Kolanowski, Ann | International Journal of Geriatric Psychiatry | 2017 |
delirium |
Delirium in Hospitalized Older Adults. | Marcantonio, E. R. | N Engl J Med | 2017 |
Aged |
A post cardiac surgery intervention to manage delirium involving families: a randomized pilot study. | Mailhot, T. Cossette, S. Cote, J. Bourbonnais, A. Cote, M. C. Lamarche, Y. Denault, A. | Nurs Crit Care | 2017 |
Cardiac surgery |
The influence of analgesic-based sedation protocols on delirium and outcomes in critically ill patients: A randomized controlled trial. | Liu, D. Lyu, J. Zhao, H. An, Y. | PloS One | 2017 |
Adolescent |
Impact of dexmedetomidine on the incidence of delirium in elderly patients after cardiac surgery: A randomized controlled trial. | Li, X. Yang, J. Nie, X. L. Zhang, Y. Li, X. Y. Li, L. H. Wang, D. X. Ma, D. | PloS One | 2017 |
NCT02267538 |
Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial. | Leung, J. M. Sands, L. P. Chen, N. Ames, C. Berven, S. Bozic, K. Burch, S. Chou, D. Covinsky, K. Deviren, V. Kinjo, S. Kramer, J. H. Ries, M. Tay, B. Vail, T. Weinstein, P. Chang, S. Meckler, G. Newman, S. Tsai, T. Voss, V. Youngblom, E. | Anesthesiology | 2017 | |
Cerebral oximetry and postoperative delirium after cardiac surgery: a randomised, controlled trial. | Lei, L. Katznelson, R. Fedorko, L. Carroll, J. Poonawala, H. Machina, M. Styra, R. Rao, V. Djaiani, G. | Anaesthesia | 2017 |
cardiac surgery |
Psychiatric symptomatology after delirium: a systematic review. | Langan, C. Sarode, D. P. Russ, T. C. Shenkin, S. D. Carson, A. Maclullich, A. M. J. | Psychogeriatrics | 2017 |
anxiety |
Multicenter assessment of sedation and delirium practices in the intensive care units in Poland - is this common practice in Eastern Europe? | Kotfis, K. Zegan-Barańska, M. Zukowski, M. Kusza, K. Kaczmarczyk, M. Ely, E. W. | BMC Anesthesiology | 2017 |
benzodiazepine derivative |
Complications Associated With Spine Surgery in Patients Aged 80 Years or Older: Japan Association of Spine Surgeons with Ambition (JASA) Multicenter Study | Kobayashi, K. Imagama, S. Ando, K. Ishiguro, N. Yamashita, M. Eguchi, Y. Matsumoto, M. Ishii, K. Hikata, T. Seki, S. Terai, H. Suzuki, A. Tamai, K. Aramomi, M. Ishikawa, T. Kimura, A. Inoue, H. Inoue, G. Miyagi, M. Saito, W. Yamada, K. Hongo, M. Nishimura | Global Spine J | 2017 |
anticoagulant agent |
Risk Factors for Delirium After Spine Surgery in Extremely Elderly Patients Aged 80 Years or Older and Review of the Literature: Japan Association of Spine Surgeons with Ambition Multicenter Study. | Kobayashi, K. Imagama, S. Ando, K. Ishiguro, N. Yamashita, M. Eguchi, Y. Matsumoto, M. Ishii, K. Hikata, T. Seki, S. Terai, H. Suzuki, A. Tamai, K. Aramomi, M. Ishikawa, T. Kimura, A. Inoue, H. Inoue, G. Miyagi, M. Saito, W. Yamada, K. Hongo, M. Matsuoka, | Global Spine J | 2017 |
complication |
Delirium characteristics and outcomes in medical and surgical lnpatients: A subgroup analysis. | Kim, S. Kim, J. J. Oh, J. Park, J. Park, J. Y. | J Crit Care | 2017 |
Delirium duration |
Persistence of Delirium after Cessation of Sedatives and Analgesics and Impact on Clinical Outcomes in Critically Ill Patients. | Kenes, M. T. Stollings, J. L. Wang, L. Girard, T. D. Ely, E. W. Pandharipande, P. P. | Pharmacotherapy | 2017 |
critical care |
South Korean Family Caregiver Involvement in Delirium Care: A Qualitative Descriptive Study. | Kang, Y. Moyle, W. Cooke, M. O'Dwyer, S. | J Gerontol Nurs | 2017 | |
Validity of the Delirium Observation Screening Scale in Identifying Delirium in Home Hospice Patients. | Jorgensen SM, Carnahan RM, Weckmann MT | The American journal of hospice & palliative care | 2016 |
delirium screening |
Discharge Plans for Geriatric Inpatients with Delirium: A Plan to Stop Antipsychotics? | Johnson, K. G. Fashoyin, A. Madden-Fuentes, R. Muzyk, A. J. Gagliardi, J. P. Yanamadala, M. | J Am Geriatr Soc | 2017 |
Aged |
Trials of statins in delirium-stymied by complex methods? | Skrobik, Y. Devlin, J. | Lancet Respir med | 2017 | |
An integrative literature review exploring the clinical management of delirium in patients with advanced cancer | Lawley, H. Hewison, A. | J Clin Nurs | 2017 |
advanced cancer |
Comparison of propofol and dexmedetomidine infused overnight to treat hyperactive and mixed ICU delirium: a protocol for the Basel ProDex clinical trial. | Hollinger, A. Ledergerber, K. von Felten, S. Sutter, R. Ruegg, S. Gantner, L. Zimmermann, S. Blum, A. Steiner, L. A. Marsch, S. Siegemund, M. | BMJ Open | 2017 |
Dexmedetomidine |
Protocol for an observational study of delirium in the post-anaesthesia care unit (PACU) as a potential predictor of subsequent postoperative delirium. | Cui, V. Tedeschi, C. M. Kronzer, V. L. McKinnon, S. L. Avidan, M. S. | BMJ Open | 2017 |
adult intensive & critical care |
Debate article: Antipsychotic medications are clinically useful for the treatment of delirium. | Meagher, D. Agar, M. R. Teodorczuk, A. | Int J Geriatr Psychiatry | 2017 |
antipsychotics |
A Novel Stress-Diathesis Model to Predict Risk of Post-operative Delirium: Implications for Intra-operative Management. | El-Gabalawy, R. Patel, R. Kilborn, K. Blaney, C. Hoban, C. Ryner, L. Funk, D. Legaspi, R. Fisher, J. A. Duffin, J. Mikulis, D. J. Mutch, W. A. C. | Front Aging Neurosci | 2017 |
neuroimaging |
Treatment of asymptomatic UTI in older delirious medical in-patients: A prospective cohort study. | Dasgupta, M. Brymer, C. Elsayed, S. | Arch Gerontol Geriatr | 2017 |
Aged |
Early geriatric consultation increases adherence to TQIP Geriatric Trauma Management Guidelines. | Southerland, L. T. Gure, T. R. Ruter, D. I. Li, M. M. Evans, D. C. | J Surg Res | 2017 |
Aged |
Post-Intensive Care Unit Psychiatric Comorbidity and Quality of Life. | Wang, S. Mosher, C. Perkins, A. J. Gao, S. Lasiter, S. Khan, S. Boustani, M. Khan, B. | Journal of Hospital Medicine | 2017 | |
Potentially modifiable factors contributing to sepsis-associated encephalopathy. | Sonneville, Romain Montmollin, Etienne Poujade, Julien Garrouste-Orgeas, Maïté Souweine, Bertrand Darmon, Michael Mariotte, Eric Argaud, Laurent Barbier, François Goldgran-Toledano, Dany Marcotte, Guillaume Dumenil, Anne-Sylvie Jamali, Samir Lacave, Gu | Intensive Care Medicine | 2017 | |
Comprehensive Geriatric Assessment for Prevention of Delirium After Hip Fracture: A Systematic Review of Randomized Controlled Trials. | Shields L, Henderson V, Caslake R | Journal of the American Geriatrics Society | 2017 |
Aged |
Age- and gender-related peculiarities of patients with delirium in the cardiac intensive care unit. | Serpytis, P. Navickas, P. Navickas, A. Serpytis, R. Navickas, G. Glaveckaite, S. | Kardiol Pol | 2017 |
age |
Delirium Frequency and Risk Factors Among Patients With Cancer in Palliative Care Unit. | Şenel G, Uysal N, Oguz G, Kaya M, Kadioullari N, Koçak N, Karaca S | The American journal of hospice & palliative care | 2017 |
adult |
Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study. | Scholtens, R. M. van Munster, B. C. van Faassen, M. van Kempen, M. F. Kema, I. P. de Rooij, S. E. | Mech Ageing Dev | 2017 |
Aged |
Association between delirium and cognitive change after cardiac surgery. | Sauer, A. C. Veldhuijzen, D. S. Ottens, T. H. Slooter, A. J. C. Kalkman, C. J. van Dijk, D. | Br J Anaesth | 2017 |
cardiac surgical procedures |
Effectiveness and Safety of an Extended ICU Visitation Model for Delirium Prevention: A Before and After Study. | Rosa, R. G. Tonietto, T. F. da Silva, D. B. Gutierres, F. A. Ascoli, A. M. Madeira, L. C. Rutzen, W. Falavigna, M. Robinson, C. C. Salluh, J. I. Cavalcanti, A. B. Azevedo, L. C. Cremonese, R. V. Haack, T. R. Eugenio, C. S. Dornelles, A. Bessel, M. Teles, | Crit Care Med | 2017 |
Aged |