What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Lived experience of the intensive care unit for patients who experienced delirium. | Whitehorne K, Gaudine A, Meadus R, Solberg S | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2015 | |
| Preoperative protein profiles in cerebrospinal fluid in elderly hip fracture patients at risk for delirium: A proteomics and validation study. | Westhoff D, Witlox J, van Aalst C, Scholtens RM, de Rooij SE, van Munster BC, de Jonghe JF, Houdijk AP, Eikelenboom P, van Westerloo DJ, van de Beek D, van Gool WA, Koenderman L | BBA clinical | 2015 | |
| Variable lung protective mechanical ventilation decreases incidence of postoperative delirium and cognitive dysfunction during open abdominal surgery. | Wang R, Chen J, Wu G | International journal of clinical and experimental medicine | 2015 | |
| Risk factors contributing to postoperative delirium in geriatric patients postorthopedic surgery. | Wang J, Li Z, Yu Y, Li B, Shao G, Wang Q | Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists | 2015 | |
| Review of delirium in patients with Parkinson's disease. | Vardy ER, Teodorczuk A, Yarnall AJ | Journal of neurology | 2015 | |
| Delirium detection and improved delirium management in older patients hospitalized for hip fracture. | Todd KS, Barry J, Hoppough S, McConnell E | International journal of orthopaedic and trauma nursing | 2015 | |
| Prospective evaluation of inappropriate unable-to-assess CAM-ICU documentations of critically ill adult patients. | Terry KJ, Anger KE, Szumita PM | Journal of intensive care | 2015 | |
| Delirium in intensive care unit patients under noninvasive ventilation: a multinational survey. | Tanaka LM, Salluh JI, Dal-Pizzol F, Barreto BB, Zantieff R, Tobar E, Esquinas A, Quarantini Lde C, Gusmao-Flores D | Revista Brasileira de terapia intensiva | 2015 |
Attitude of Health Personnel, Critical Care, Delirium, diagnosis, Health Care Surveys, Humans, Intensive Care Units, Noninvasive Ventilation |
| Acetylcholinesterase Inhibitors for Delirium in Older Adults. | Tampi RR, Tampi DJ, Ghori AK | American journal of Alzheimer's disease and other dementias | 2016 | |
| Influence of Granulocyte-Macrophage Colony-Stimulating Factor or Influenza Vaccination on HLA-DR, Infection and Delirium Days in Immunosuppressed Surgical Patients: Double Blind, Randomised Controlled Trial. | Spies C, Luetz A, Lachmann G, Renius M, von Haefen C, Wernecke KD, Bahra M, Schiemann A, Paupers M, Meisel C | PloS one | 2015 | |
| Validation of the confusion assessment method in detecting postoperative delirium in cardiac surgery patients. | Smulter N, Lingehall HC, Gustafson Y, Olofsson B, Engström KG | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2015 | |
| Risk Factors for Delirium After Spinal Surgery: A Meta-Analysis. | Shi C, Yang C, Gao R, Yuan W | World neurosurgery | 2015 |
Aged, Aged, 80 and over, Delirium, epidemiology, Humans, Neurosurgical Procedures, adverse effects, Postoperative Complications, epidemiology, Risk Factors, Spine, surgery |
| Valproic Acid for Treatment of Hyperactive or Mixed Delirium: Rationale and Literature Review. | Sher Y, Miller Cramer AC, Ament A, Lolak S, Maldonado JR | Psychosomatics | 2015 | |
| The Successful Aging After Elective Surgery Study: Cohort Description and Data Quality Procedures. | Schmitt EM, Saczynski JS, Kosar CM, Jones RN, Alsop DC, Fong TG, Metzger E, Cooper Z, Marcantonio ER, Travison T, Inouye SK, | Journal of the American Geriatrics Society | 2015 | |
| The Montreal Cognitive Assessment: Creating a Crosswalk with the Mini-Mental State Examination. | Saczynski JS, Inouye SK, Guess J, Jones RN, Fong TG, Nemeth E, Hodara A, Ngo L, Marcantonio ER | Journal of the American Geriatrics Society | 2015 |
Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Cross-Sectional Studies, Delirium, diagnosis, Dementia, diagnosis, Female, Humans, Male, Mild Cognitive Impairment, diagnosis, Neuropsychological Tests |
| Delirium After Hip Fracture: Still a Problem. | Rudolph JL | Anesthesia and analgesia | 2015 |
Delirium, mortality, Female, Hip Fractures, mortality, Humans, Male, Postoperative Complications, mortality |
| The Bromhead Care Home Service: the impact of a service for care home residents with dementia on hospital admission and dying in preferred place of care. | Garden G, Green S, Pieniak S, Gladman J | Clinical medicine (London, England) | 2016 | |
| The Association Between Preoperative Frailty and Postoperative Delirium After Cardiac Surgery. | Brown CH, Max L, LaFlam A, Kirk L, Gross A, Arora R, Neufeld K, Hogue CW, Walston J, Pustavoitau A | Anesthesia and analgesia | 2016 | |
| Antipsychotic Drug Use and Screening for Delirium in Mechanically Ventilated Patients in Canadian Intensive Care Units: An Observational Study. | Thiboutot Z, Perreault MM, Williamson DR, Rose L, Mehta S, Guenette MD, Cook D, Burry L | The Canadian journal of hospital pharmacy | 2016 | |
| Abnormal Mini-Cog Is Associated with Higher Risk of Complications and Delirium in Geriatric Patients with Fracture. | Heng M, Eagen CE, Javedan H, Kodela J, Weaver MJ, Harris MB | The Journal of bone and joint surgery. American volume | 2016 | |
| DELirium Prediction Based on Hospital Information (Delphi) in General Surgery Patients. | Kim MY, Park UJ, Kim HT, Cho WH | Medicine | 2016 | |
| Serum Anticholinergic Activity and Cognitive and Functional Adverse Outcomes in Older People: A Systematic Review and Meta-Analysis of the Literature. | Salahudeen MS, Chyou TY, Nishtala PS | PloS one | 2016 | |
| Impact of length of red blood cells transfusion on postoperative delirium in elderly patients undergoing hip fracture surgery: A cohort study. | Zhang ZY, Gao DP, Yang JJ, Sun XR, Zhang H, Hu J, Fang ZY, Yang JJ, Ji MH | Injury | 2016 | |
| Nursing intervention versus usual care to improve delirium among home-dwelling older adults receiving homecare after hospitalization: feasibility and acceptability of a Randomized Controlled Trail. | Verloo H, Goulet C, Morin D, von Gunten A | BMC nursing | 2016 | |
| Use of medications that antagonize mediators of inflammatory responses may reduce the risk of delirium in older adults: a nested case-control study. | Cole MG, McCusker J, Wilchesky M, Voyer P, Monette J, Champoux N, Vu M, Ciampi A, Belzile E | International journal of geriatric psychiatry | 2016 | |
| Frequency of full, partial and no recovery from subsyndromal deliriumin older hospital inpatients. | Cole MG, Bailey R, Bonnycastle M, McCusker J, Fung S, Ciampi A, Belzile E | International journal of geriatric psychiatry | 2016 | |
| Preventing ICU Subsyndromal Delirium Conversion to Delirium With Low-Dose IV Haloperidol: A Double-Blind, Placebo-Controlled Pilot Study. | Al-Qadheeb NS, Skrobik Y, Schumaker G, Pacheco MN, Roberts RJ, Ruthazer RR, Devlin JW | Critical care medicine | 2016 | |
| Postoperative plasma 8-iso-prostaglandin F2α levels are associated with delirium and cognitive dysfunction in elderly patients after hip fracture surgery. | Zheng YB, Ruan GM, Fu JX, Su ZL, Cheng P, Lu JZ | Clinica chimica acta; international journal of clinical chemistry | 2016 | |
| Profiles of delirium and the clinical outcomes of patients who underwent coronary artery bypass grafting: a prospective study from China. | Zhang W, Hu W, Shen M, Ye X, Huang Y, Sun Y | Journal of clinical nursing | 2016 |
Adult, Aged, Aged, 80 and over, China, Coronary Artery Bypass, adverse effects, Coronary Artery Disease, psychology, Delirium, diagnosis, Female, Humans, Length of Stay, Male, Middle Aged, Outcome Assessment (Health Care), Prospective Studies |
| Risk factors for postoperative delirium following hip fracture repair in elderly patients: a systematic review and meta-analysis. | Yang Y, Zhao X, Dong T, Yang Z, Zhang Q, Zhang Y | Aging clinical and experimental research | 2017 | |
| RADAR: A Measure of the Sixth Vital Sign? | Voyer P, Champoux N, Desrosiers J, Landreville P, McCusker J, Monette J, Savoie M, Carmichael PH, Richard H, Richard S | Clinical nursing research | 2016 | |
| Association between frailty and delirium in older adult patients discharged from hospital. | Verloo H, Goulet C, Morin D, von Gunten A | Clinical interventions in aging | 2016 | |
| Psychometric properties and feasibility of instruments for the detection of delirium in older hospitalized patients: a systematic review. | van Velthuijsen EL, Zwakhalen SM, Warnier RM, Mulder WJ, Verhey FR, Kempen GI | International journal of geriatric psychiatry | 2016 | |
| The patient's perception of a delirium: A qualitative research in a Belgian intensive care unit. | Van Rompaey B, Van Hoof A, van Bogaert P, Timmermans O, Dilles T | Intensive & critical care nursing : the official journal of the British Association of Critical Care Nurses | 2016 | |
| Biomarkers of Delirium in a Low-Risk Community-Acquired Pneumonia-Induced Sepsis. | Tomasi CD, Vuolo F, Generoso J, Soares M, Barichello T, Quevedo J, Ritter C, Dal-Pizzol F | Molecular neurobiology | 2016 | |
| How to advance prediction of postoperative delirium? A secondary analysis comparing three methods for very early assessment of elderly patients after surgery and early prediction of delirium. | Stukenberg S, Franck M, Spies CD, Neuner B, Myers I, Radtke FM | Minerva anestesiologica | 2016 | |
| A Flipped Classroom Approach to Improving the Quality of Delirium Care Using an Interprofessional Train-the-Trainer Program. | Sockalingam S, James SL, Sinyi R, Carroll A, Laidlaw J, Yanofsky R, Sheehan K | The Journal of continuing education in the health professions | 2016 | |
| Reduced Cerebral Perfusion Pressure during Lung Transplant Surgery Is Associated with Risk, Duration, and Severity of Postoperative Delirium. | Smith PJ, Blumenthal JA, Hoffman BM, Rivelli SK, Palmer SM, Davis RD, Mathew JP | Annals of the American Thoracic Society | 2016 | |
| Depressive Symptoms and Risk of Postoperative Delirium. | Smith PJ, Attix DK, Weldon BC, Monk TG | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2016 | |
| Dynamic light application therapy to reduce the incidence and duration of delirium in intensive-care patients: a randomised controlled trial. | Simons KS, Laheij RJ, van den Boogaard M, Moviat MA, Paling AJ, Polderman FN, Rozendaal FW, Salet GA, van der Hoeven JG, Pickkers P, de Jager CP | The Lancet. Respiratory medicine | 2016 | |
| Interventions for preventing delirium in hospitalised non-ICU patients. | Siddiqi N, Harrison JK, Clegg A, Teale EA, Young J, Taylor J, Simpkins SA | The Cochrane database of systematic reviews | 2016 | |
| Validation of the Sour Seven Questionnaire for screening delirium in hospitalized seniors by informal caregivers and untrained nurses. | Shulman RW, Kalra S, Jiang JZ | BMC geriatrics | 2016 |
Aged, Aged, 80 and over, Caregivers, psychology, Delirium, diagnosis, Family, psychology, Female, Geriatric Assessment, methods, Hospitalization, Humans, Male, Mass Screening, methods, Nurse’s Role, psychology, Pilot Projects, Surveys and Questionnaires, standards |
| Efficacy and safety of haloperidol for in-hospital delirium prevention and treatment: A systematic review of current evidence. | Schrijver EJ, de Graaf K, de Vries OJ, Maier AB, Nanayakkara PW | European journal of internal medicine | 2016 | |
| Systematic review and meta-analysis of risk factors for postoperative delirium among older patients undergoing gastrointestinal surgery. | Scholz AF, Oldroyd C, McCarthy K, Quinn TJ, Hewitt J | The British journal of surgery | 2016 | |
| Validation of a Delirium Risk Assessment Using Electronic Medical Record Information. | Rudolph JL, Doherty K, Kelly B, Driver JA, Archambault E | Journal of the American Medical Directors Association | 2016 | |
| The implementation of a nonpharmacologic protocol to prevent intensive care delirium. | Rivosecchi RM, Kane-Gill SL, Svec S, Campbell S, Smithburger PL | Journal of critical care | 2016 | |
| Delirium superimposed on dementia: a survey of delirium specialists shows a lack of consensus in clinical practice and research studies. | Richardson S, Teodorczuk A, Bellelli G, Davis DH, Neufeld KJ, Kamholz BA, Trabucchi M, MacLullich AM, Morandi A | International psychogeriatrics / IPA | 2016 | |
| Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial. | Reade MC, Eastwood GM, Bellomo R, Bailey M, Bersten A, Cheung B, Davies A, Delaney A, Ghosh A, van Haren F, Harley N, Knight D, McGuiness S, Mulder J, O'Donoghue S, Simpson N, Young P, , | JAMA | 2016 |
Aged, Australia, Delirium, complications, Dexmedetomidine, administration & dosage, Double-Blind Method, Female, Humans, Hypnotics and Sedatives, administration & dosage, Male, Middle Aged, New Zealand, Proportional Hazards Models, Psychomotor Agitation, drug therapy, Respiration, Artificial, statistics & numerical data, Time Factors, Treatment Outcome, Ventilator Weaning, contraindications |
| Functional interrelationship of brain aging and delirium. | Rapazzini P | Aging clinical and experimental research | 2016 | |
| Delirium risk stratification in consecutive unselected admissions to acute medicine: validation of externally derived risk scores. | Pendlebury ST, Lovett N, Smith SC, Cornish E, Mehta Z, Rothwell PM | Age and ageing | 2016 | |
| A Family-Focused Delirium Educational Initiative With Practice and Research Implications. | Paulson CM, Monroe T, McDougall GJ, Fick DM | Gerontology & geriatrics education | 2016 | |
| How do doctors and nurses manage delirium in intensive care units? A qualitative study using focus groups. | Palacios-Ceña D, Cachón-Pérez JM, Martínez-Piedrola R, Gueita-Rodriguez J, Perez-de-Heredia M, Fernández-de-Las-Peñas C | BMJ open | 2016 | |
| The role of anesthesia in the prevention of postoperative delirium: a systematic review. | Orena EF, King AB, Hughes CG | Minerva anestesiologica | 2016 | |
| Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery in the Sugammadex Era: A Retrospective Study. | Oh CS, Rhee KY, Yoon TG, Woo NS, Hong SW, Kim SH | BioMed research international | 2016 | |
| High prolactin levels are associated with more delirium in septic patients. | Nguyen DN, Huyghens L, Schiettecatte J, Smitz J, Vincent JL | Journal of critical care | 2016 | |
| Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta-Analysis. | Neufeld KJ, Yue J, Robinson TN, Inouye SK, Needham DM | Journal of the American Geriatrics Society | 2016 | |
| Depressive Symptoms Before, During, and After Delirium: A Literature Review. | Nelson S, Rustad JK, Catalano G, Stern TA, Kozel FA | Psychosomatics | 2016 | |
| Rosuvastatin versus placebo for delirium in intensive care and subsequent cognitive impairment in patients with sepsis-associated acute respiratory distress syndrome: an ancillary study to a randomised controlled trial. | Needham DM, Colantuoni E, Dinglas VD, Hough CL, Wozniak AW, Jackson JC, Morris PE, Mendez-Tellez PA, Ely EW, Hopkins RO | The Lancet. Respiratory medicine | 2016 | |
| Cyproheptadine for the Prevention of Postoperative Delirium: A Pilot Study. | Mohammadi M, Ahmadi M, Khalili H, Cheraghchi H, Arbabi M | The Annals of pharmacotherapy | 2016 | |
| Delirium after surgical and transcatheter aortic valve replacement is associated with increased mortality. | Maniar HS, Lindman BR, Escallier K, Avidan M, Novak E, Melby SJ, Damiano MS, Lasala J, Quader N, Rao RS, Lawton J, Moon MR, Helsten D, Pasque MK, Damiano RJ, Zajarias A | The Journal of thoracic and cardiovascular surgery | 2016 | |
| The Efficacy of Earplugs as a Sleep Hygiene Strategy for Reducing Delirium in the ICU: A Systematic Review and Meta-Analysis. | Litton E, Carnegie V, Elliott R, Webb SA | Critical care medicine | 2016 | |
| Delirium in critical care: a study of incidence, prevalence, and associated factors in the tertiary care hospital of older Thai adults. | Limpawattana P, Panitchote A, Tangvoraphonkchai K, Suebsoh N, Eamma W, Chanthonglarng B, Tiamkao S | Aging & mental health | 2016 | |
| Comparison of cognitive and neuropsychiatric profiles in hospitalised elderly medical patients with delirium, dementia and comorbid delirium-dementia. | Leonard M, McInerney S, McFarland J, Condon C, Awan F, O'Connor M, Reynolds P, Meaney AM, Adamis D, Dunne C, Cullen W, Trzepacz PT, Meagher DJ | BMJ open | 2016 | |
| Identification of sub-groups in acutely ill elderly patients with delirium: a cluster analysis. | Lagarto L, Cerejeira J | International psychogeriatrics / IPA | 2016 | |
| Development and validation of the Thai version of the 4 'A's Test for delirium screening in hospitalized elderly patients with acute medical illnesses. | Kuladee S, Prachason T | Neuropsychiatric disease and treatment | 2016 | |
| Delirium is a risk factor for further cognitive decline in cognitively impaired hip fracture patients. | Krogseth M, Watne LO, Juliebø V, Skovlund E, Engedal K, Frihagen F, Wyller TB | Archives of gerontology and geriatrics | 2016 | |
| Surgical procedure and postoperative delirium in geriatric hip fracture patients. | Kavouspour C, Wang N, Mears SC, Oh ES, Sieber FE | European journal of anaesthesiology | 2016 | |
| The effect of range of motion exercises on delirium prevention among patients aged 65 and over in intensive care units. | Karadas C, Ozdemir L | Geriatric nursing (New York, N.Y.) | 2016 | |
| Managing verbal agitation in people with dementia and delirium. | Inkley F, Goldberg S | Nursing older people | 2016 | |
| The Fog of War: Delirium Prevalence in a Combat Intensive Care Unit. | Ingalls NK, Armstrong B, Hester M, Hatzfeld JJ, Robinson BR, Fortuna GR | Military medicine | 2016 | |
| General versus spinal anaesthesia and postoperative delirium in an orthogeriatric population. | Ilango S, Pulle RC, Bell J, Kuys SS | Australasian journal on ageing | 2016 | |
| Measuring delirium point-prevalence in two Australian palliative care inpatient units. | Hosie A, Lobb E, Agar M, Davidson P, Chye R, Lam L, Phillips J | International journal of palliative nursing | 2016 |
Aged, Aged, 80 and over, Australia, epidemiology, Cross-Sectional Studies, Delirium, diagnosis, Female, Humans, Inpatients, statistics & numerical data, Male, Mass Screening, statistics & numerical data, Middle Aged, Palliative Care, statistics & numerical data, Prevalence, Prospective Studies |
| The Relationship Between Sleep-Wake Cycle Disturbance and Trajectory of Cognitive Recovery During Acute Traumatic Brain Injury. | Holcomb EM, Towns S, Kamper JE, Barnett SD, Sherer M, Evans C, Nakase-Richardson R | The Journal of head trauma rehabilitation | 2016 | |
| Effectiveness of the STOPP/START (Screening Tool of Older Persons' potentially inappropriate Prescriptions/Screening Tool to Alert doctors to the Right Treatment) criteria: systematic review and meta-analysis of randomized controlled studies. | Hill-Taylor B, Walsh KA, Stewart S, Hayden J, Byrne S, Sketris IS | Journal of clinical pharmacy and therapeutics | 2016 | |
| Impact of multicomponent, nonpharmacologic interventions on perioperative cortisol and melatonin levels and postoperative delirium in elderly oral cancer patients. | Guo Y, Sun L, Li L, Jia P, Zhang J, Jiang H, Jiang W | Archives of gerontology and geriatrics | 2016 |
Aged, Delirium, diagnosis, Female, Humans, Hydrocortisone, urine, Intensive Care Units, Male, Melatonin, urine, Middle Aged, Mouth Neoplasms, surgery, Postoperative Care, Postoperative Complications, prevention & control, Preoperative Care, Preoperative Period, Psychomotor Agitation, prevention & control, Sleep, drug effects, Treatment Outcome |
| Prevalence and risk factors of postoperative delirium in elderly hip fracture patients. | Guo Y, Jia P, Zhang J, Wang X, Jiang H, Jiang W | The Journal of international medical research | 2016 | |
| Prevalence of delirium among patients at a cancer ward: Clinical risk factors and prediction by bedside cognitive tests. | Grandahl MG, Nielsen SE, Koerner EA, Schultz HH, Arnfred SM | Nordic journal of psychiatry | 2016 | |
| Validation of the delirium observation screening scale in a hospitalized older population. | Gavinski K, Carnahan R, Weckmann M | Journal of hospital medicine | 2016 | |
| Delirium recall - an integrative review. | Fuller V | Journal of clinical nursing | 2016 | |
| Concordance between the delirium motor subtyping scale (DMSS) and the abbreviated version (DMSS-4) over longitudinal assessment in elderly medical inpatients. | Fitzgerald J, O'Regan N, Adamis D, Timmons S, Dunne C, Trzepacz P, Meagher D | International psychogeriatrics / IPA | 2016 | |
| Obesity and post-operative cognitive dysfunction: a systematic review and meta-analysis. | Feinkohl I, Winterer G, Pischon T | Diabetes/metabolism research and reviews | 2016 | |
| Antipsychotic-induced akathisia in delirium: A systematic review. | Espi Forcen F, Matsoukas K, Alici Y | Palliative & supportive care | 2016 | |
| Delirium in patients with advanced cancer. | Lawlor PG, Bruera ED | Hematology/oncology clinics of North America | 2002 |
Causality, Communication, Conscious Sedation, Delirium, diagnosis, Diagnosis, Differential, Ethics, Medical, Evidence-Based Medicine, Family, psychology, Humans, Mass Screening, Neoplasm Staging, Neoplasms, complications, Palliative Care, methods, Patient Advocacy, Practice Guidelines as Topic, Severity of Illness Index |
| Postdischarge Clinical Outcomes in Older Medical Patients with an Emergency Department Stay-Associated Delirium Onset. | Bo M, Bonetto M, Bottignole G, Porrino P, Coppo E, Tibaldi M, Ceci G, Raspo S, Cappa G, Bellelli G | Journal of the American Geriatrics Society | 2016 | |
| Stop Using Antipsychotics to Treat or Prevent Delirium-They Are No Better Than Placebo. | Barry HC | American family physician | 2016 | |
| Higher C-Reactive Protein Levels Predict Postoperative Delirium in Older Patients Undergoing Major Elective Surgery: A Longitudinal Nested Case-Control Study. | Dillon ST, Vasunilashorn SM, Ngo L, Otu HH, Inouye SK, Jones RN, Alsop DC, Kuchel GA, Metzger ED, Arnold SE, Marcantonio ER, Libermann TA | Biological psychiatry | 2016 | |
| Sex Differences in Hip Fracture Surgery: Preoperative Risk Factors for Delirium and Postoperative Outcomes. | Oh ES, Sieber FE, Leoutsakos JM, Inouye SK, Lee HB | Journal of the American Geriatrics Society | 2016 | |
| A Decrease in the Volume of Gray Matter as a Risk Factor for Postoperative Delirium Revealed by an Atlas-based Method. | Shioiri A, Kurumaji A, Takeuchi T, Nemoto K, Arai H, Nishikawa T | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2016 | |
| Basic Geriatrics Knowledge Among Internal Medicine Trainees in a Teaching Hospital in Saudi Arabia. | Al-Aama T | Journal of cross-cultural gerontology | 2016 | |
| Expert opinions on the first-line pharmacological treatment for delirium in Japan: a conjoint analysis. | Okumura Y, Hatta K, Wada K, Takeuchi T, Kishi Y, | International psychogeriatrics / IPA | 2016 | |
| Cognitive Reserve and Postoperative Delirium in Older Adults. | Tow A, Holtzer R, Wang C, Sharan A, Kim SJ, Gladstein A, Blum Y, Verghese J | Journal of the American Geriatrics Society | 2016 | |
| Managing the Care of the Older Patient with Delirium and Dementia. | Seeganna C, Antai-Otong D | The Nursing clinics of North America | 2016 | |
| Associations Between Delirium and Preoperative Cerebrospinal Fluid C-Reactive Protein, Interleukin-6, and Interleukin-6 Receptor in Individuals with Acute Hip Fracture. | Neerland BE, Hall RJ, Seljeflot I, Frihagen F, MacLullich AM, Raeder J, Wyller TB, Watne LO | Journal of the American Geriatrics Society | 2016 | |
| Emerging Role of Melatonin and Melatonin Receptor Agonists in Sleep and Delirium in Intensive Care Unit Patients. | Mo Y, Scheer CE, Abdallah GT | Journal of intensive care medicine | 2016 | |
| International Psychogeriatrics Paper of the year 2015: the use of modern technology to tackle an old challenge - improving the diagnosis of delirium in the hospital setting. | Lautenschlager NT, Ames D | International psychogeriatrics / IPA | 2016 | |
| Application of Clinical Practice Guidelines for Pain, Agitation, and Delirium. | Krupp A, Balas MC | Critical care nursing clinics of North America | 2016 | |
| Early recognition of delirium in trauma patients. | Johnson K, Diana S, Todd J, McFarren A, Domb A, Mangram A, Veale K | Intensive & critical care nursing | 2016 | |
| A quick and easy delirium assessment for nonphysician research personnel. | Han JH, Wilson A, Graves AJ, Shintani A, Schnelle JF, Ely EW | The American journal of emergency medicine | 2016 | |
| Patients prone for postoperative delirium: preoperative assessment, perioperative prophylaxis, postoperative treatment. | Guenther U, Riedel L, Radtke FM | Current opinion in anaesthesiology | 2016 | |
| Family Caregivers' Knowledge of Delirium and Preferred Modalities for Receipt of Information. | Bull MJ, Boaz L, Sjostedt JM | Journal of applied gerontology : the official journal of the Southern Gerontological Society | 2016 |