What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Systemic inflammation impairs attention and cognitive flexibility but not associative learning in aged rats: possible implications for delirium. | Culley DJ, Snayd M, Baxter MG, Xie Z, Lee IH, Rudolph J, Inouye SK, Marcantonio ER, Crosby G | Frontiers in aging neuroscience | 2014 | |
| The Prevention of Delirium and Complications Associated with Surgical Treatments (PODCAST) study: protocol for an international multicentre randomised controlled trial. | Avidan MS, Fritz BA, Maybrier HR, Muench MR, Escallier KE, Chen Y, Ben Abdallah A, Veselis RA, Hudetz JA, Pagel PS, Noh G, Pryor K, Kaiser H, Arya VK, Pong R, Jacobsohn E, Grocott HP, Choi S, Downey RJ, Inouye SK, Mashour GA | BMJ open | 2014 | |
| Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle. | Balas MC, Vasilevskis EE, Olsen KM, Schmid KK, Shostrom V, Cohen MZ, Peitz G, Gannon DE, Sisson J, Sullivan J, Stothert JC, Lazure J, Nuss SL, Jawa RS, Freihaut F, Ely EW, Burke WJ | Critical care medicine | 2014 |
Adult, Aged, Clinical Protocols, Cohort Studies, Delirium, therapy, Exercise, Female, Humans, Hypnotics and Sedatives, therapeutic use, Immobilization, adverse effects, Intensive Care, methods, Male, Middle Aged, Prospective Studies, Regression Analysis, Respiration, Artificial, adverse effects, Treatment Outcome, Ventilator Weaning, methods |
| Comparison of symptoms of delirium across various motoric subtypes. | Grover S, Sharma A, Aggarwal M, Mattoo SK, Chakrabarti S, Malhotra S, Avasthi A, Kulhara P, Basu D | Psychiatry and clinical neurosciences | 2014 | |
| The efficacy of peri-operative interventions to decrease postoperative delirium in non-cardiac surgery: a systematic review and meta-analysis. | Moyce Z, Rodseth RN, Biccard BM | Anaesthesia | 2014 |
Delirium, prevention & control, Humans, Perioperative Care, methods, Postoperative Complications, prevention & control, Referral and Consultation |
| Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients. | Alexander SA, Ren D, Gunn SR, Kochanek PM, Tate J, Ikonomovic M, Conley YP | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2014 | |
| Decreasing inappropriate unable-to-assess ratings for the confusion assessment method for the intensive care unit. | Swan JT | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2014 | |
| Anticholinergic activity in cerebrospinal fluid and serum in individuals with hip fracture with and without delirium. | Watne LO, Hall RJ, Molden E, Raeder J, Frihagen F, MacLullich AM, Juliebø V, Nyman A, Meagher D, Wyller TB | Journal of the American Geriatrics Society | 2014 |
APACHE, Activities of Daily Living, Aged, Aged, 80 and over, Cholinergic Antagonists, blood, Comorbidity, Delirium, diagnosis, Female, Hip Fractures, complications, Humans, Male, Middle Aged, Norway, Prospective Studies, Questionnaires, Scotland, Severity of Illness Index |
| Antipsychotics for delirium in the general hospital setting in consecutive 2453 inpatients: a prospective observational study. | Hatta K, Kishi Y, Wada K, Odawara T, Takeuchi T, Shiganami T, Tsuchida K, Oshima Y, Uchimura N, Akaho R, Watanabe A, Taira T, Nishimura K, Hashimoto N, Usui C, Nakamura H | International journal of geriatric psychiatry | 2014 | |
| The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts. | Inouye SK, Kosar CM, Tommet D, Schmitt EM, Puelle MR, Saczynski JS, Marcantonio ER, Jones RN | Annals of internal medicine | 2014 |
Activities of Daily Living, Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Delirium, diagnosis, Female, Hospital Costs, Humans, Length of Stay, Male, Nursing Homes, Psychological Tests, Psychometrics, Severity of Illness Index |
| A tale of two methods: chart and interview methods for identifying delirium. | Saczynski JS, Kosar CM, Xu G, Puelle MR, Schmitt E, Jones RN, Marcantonio ER, Wong B, Isaza I, Inouye SK | Journal of the American Geriatrics Society | 2014 |
Aged, Aged, 80 and over, Cohort Studies, Delirium, diagnosis, Female, Humans, Interview, Psychological, methods, Male, Medical Records, Prospective Studies, Psychological Tests, Reproducibility of Results, Severity of Illness Index |
| Effect of leaflet-based intervention on family members of terminally ill patients with cancer having delirium: historical control study. | Otani H, Morita T, Uno S, Yamamoto R, Hirose H, Matsubara T, Takigawa C, Sasaki K | The American journal of hospice & palliative care | 2014 | |
| Preparation to care for confused older patients in general hospitals: a study of UK health professionals. | Griffiths A, Knight A, Harwood R, Gladman JR | Age and ageing | 2014 | |
| Prediction of delirium in critically ill patients with elevated C-reactive protein. | Zhang Z, Pan L, Deng H, Ni H, Xu X | Journal of critical care | 2014 | |
| Barriers and facilitators to implementing delirium rounds in a clinical trial across three diverse hospital settings. | Yevchak AM, Fick DM, McDowell J, Monroe T, May K, Grove L, Kolanowski AM, Waller JL, Inouye SK | Clinical nursing research | 2014 | |
| Feasibility and acceptability of a delirium prevention program for cognitively impaired long term care residents: a participatory approach. | Voyer P, McCusker J, Cole MG, Monette J, Champoux N, Vu M, Ciampi A, Sanche S, Richard S, de Raad M | Journal of the American Medical Directors Association | 2014 | |
| Safety incidents involving confused and forgetful older patients in a specialised care setting - analysis of the safety incidents reported to the HaiPro reporting system. | Kinnunen-Luovi K, Saarnio R, Isola A | Journal of clinical nursing | 2014 | |
| Prognosis of delirium in hospitalized elderly: worse than we thought. | Dasgupta M, Brymer C | International journal of geriatric psychiatry | 2014 | |
| Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. | Brummel NE, Jackson JC, Pandharipande PP, Thompson JL, Shintani AK, Dittus RS, Gill TM, Bernard GR, Ely EW, Girard TD | Critical care medicine | 2014 |
Activities of Daily Living, Aged, Delirium, complications, Female, Humans, Intensive Care Units, Male, Middle Aged, Prospective Studies, Questionnaires, Respiration, Artificial, Survivors, Time Factors |
| Validation and psychometric properties of the Delirium Motor Subtype Scale in elderly hip fracture patients (Dutch version). | Slor CJ, Adamis D, Jansen RW, Meagher DJ, Witlox J, Houdijk AP, de Jonghe JF | Archives of gerontology and geriatrics | 2014 |
Aged, Aged, 80 and over, Delirium, classification, Female, Fracture Fixation, Hip Fractures, complications, Humans, Male, Motor Activity, Netherlands, Psychiatric Status Rating Scales, ROC Curve, Reproducibility of Results, Severity of Illness Index |
| Delirium is a predictor of in-hospital mortality in elderly patients with community acquired pneumonia. | Pieralli F, Vannucchi V, Mancini A, Grazzini M, Paolacci G, Morettini A, Nozzoli C | Internal and emergency medicine | 2014 | |
| Delirium in elderly people. | Inouye SK, Westendorp RG, Saczynski JS | Lancet | 2014 |
Aged, Biomedical Research, methods, Cognition Disorders, etiology, Delirium, diagnosis, Dementia, etiology, Humans, Prognosis, Risk Factors |
| Delirium in adult patients receiving palliative care: a systematic review of the literature. | Sánchez-Román S, Beltrán Zavala C, Lara Solares A, Chiquete E | Revista de psiquiatrí́a y salud mental | 2014 | |
| Is delirium an unrecognized threat to patient safety in Korean intensive care units? | Moon KJ, Piao J, Jin Y, Lee SM | Journal of nursing care quality | 2014 | |
| The impact of soluble interleukin-2 receptor as a biomarker of delirium. | Baranyi A, Rothenhäusler HB | Psychosomatics | 2014 | |
| Pharmacologic risk factors for post-operative delirium in total joint arthroplasty patients: a case-control study. | Nandi S, Harvey WF, Saillant J, Kazakin A, Talmo C, Bono J | The Journal of arthroplasty | 2014 |
Aged, Analgesics, Opioid, adverse effects, Anesthetics, adverse effects, Arthroplasty, Replacement, Hip, adverse effects, Arthroplasty, Replacement, Knee, adverse effects, Benzodiazepines, adverse effects, Case-Control Studies, Cognition Disorders, Delirium, chemically induced, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors |
| Effects of a modified Hospital Elder Life Program on frailty in individuals undergoing major elective abdominal surgery. | Chen CC, Chen CN, Lai IR, Huang GH, Saczynski JS, Inouye SK | Journal of the American Geriatrics Society | 2014 |
Abdomen, surgery, Activities of Daily Living, Aged, Female, Frail Elderly, psychology, Geriatric Assessment, methods, Hospitalization, statistics & numerical data, Humans, Male, Odds Ratio, Postoperative Care, methods, Postoperative Complications, prevention & control, Surgical Procedures, Elective, Taiwan |
| First Spanish version of the Memorial Delirium Assessment Scale: psychometric properties, responsiveness, and factor loadings. | Noguera A, Carvajal A, Alonso-Babarro A, Chisholm G, Bruera E, Centeno C | Journal of pain and symptom management | 2014 | |
| Detection of delirium in palliative care unit patients: a prospective descriptive study of the Delirium Observation Screening Scale administered by bedside nurses. | Detroyer E, Clement PM, Baeten N, Pennemans M, Decruyenaere M, Vandenberghe J, Menten J, Joosten E, Milisen K | Palliative medicine | 2014 | |
| Intensive care delirium - effect on memories and health-related quality of life - a follow-up study. | Svenningsen H, Tønnesen EK, Videbech P, Frydenberg M, Christensen D, Egerod I | Journal of clinical nursing | 2014 | |
| Palliative care in advanced dementia. | Merel S, DeMers S, Vig E | Clinics in geriatric medicine | 2014 | |
| Effect of medications with anti-cholinergic properties on cognitive function, delirium, physical function and mortality: a systematic review. | Fox C, Smith T, Maidment I, Chan WY, Bua N, Myint PK, Boustani M, Kwok CS, Glover M, Koopmans I, Campbell N | Age and ageing | 2014 | |
| Methodology of studying incident delirium after hip fracture. | Regal P | Journal of the American Geriatrics Society | 2014 |
Cholinergic Antagonists, blood, Delirium, diagnosis, Female, Hip Fractures, complications, Humans, Male |
| Delirium recognition by family: European portuguese validation study of the family confusion assessment method. | Martins S, Conceição F, Paiva JA, Simões MR, Fernandes L | Journal of the American Geriatrics Society | 2014 | |
| The assessment of the T102C polymorphism of the 5HT2a receptor gene, 3723G/A polymorphism of the NMDA receptor 3A subunit gene (GRIN3A) and 421C/A polymorphism of the NMDA receptor 2B subunit gene (GRIN2B) among cardiac surgery patients with and without d | Kazmierski J, Sieruta M, Banys A, Jaszewski R, Sobow T, Liberski P, Kloszewska I | General hospital psychiatry | 2014 | |
| Inflammation biomarkers and delirium in critically ill patients: new insights? | Sobbi SC, van den Boogaard M | Critical care (London, England) | 2014 | |
| Delirium among critically ill adults: Evaluation of the psychometric properties of the Italian 'Confusion Assessment Method for the Intensive Care Unit'. | Gaspardo P, Peressoni L, Comisso I, Mistraletti G, Ely EW, Morandi A | Intensive & critical care nursing : the official journal of the British Association of Critical Care Nurses | 2014 | |
| Delirium in older people in hospital: an education programme. | Varghese NC, Macaden L, Premkumar B, Mathews P, Kumar S | British journal of nursing (Mark Allen Publishing) | 2014 |
Adult, Aged, Aged, 80 and over, Curriculum, Delirium, diagnosis, Education, Nursing, Continuing, Female, Geriatric Assessment, Great Britain, Health Knowledge, Attitudes, Practice, Humans, India, Male, Middle Aged, Nurse-Patient Relations, Nursing Staff, Hospital, education, Program Evaluation, Young Adult |
| Burst suppression on processed electroencephalography as a predictor of postcoma delirium in mechanically ventilated ICU patients. | Andresen JM, Girard TD, Pandharipande PP, Davidson MA, Ely EW, Watson PL | Critical care medicine | 2014 |
APACHE, Aged, Brain, physiopathology, Coma, complications, Deep Sedation, adverse effects, Delirium, diagnosis, Electroencephalography, statistics & numerical data, Female, Humans, Intensive Care Units, statistics & numerical data, Logistic Models, Male, Middle Aged, Prognosis, Proportional Hazards Models, Prospective Studies, Respiration, Artificial, adverse effects |
| Postoperative plasma copeptin levels independently predict delirium and cognitive dysfunction after coronary artery bypass graft surgery. | Dong S, Li CL, Liang WD, Chen MH, Bi YT, Li XW | Peptides | 2014 | |
| Evaluation of a nurse mentoring intervention to family caregivers in the management of delirium after cardiac surgery (MENTOR_D): a study protocol for a randomized controlled pilot trial. | Mailhot T, Cossette S, Bourbonnais A, Côté J, Denault A, Côté MC, Lamarche Y, Guertin MC | Trials | 2014 | |
| Delirium in older persons: evaluation and management. | Kalish VB, Gillham JE, Unwin BK | American family physician | 2014 |
Aged, Aged, 80 and over, Delirium, diagnosis, Female, Humans, Risk Factors |
| Delirium: another factor when considering type of anesthetic for hip fracture surgery in adults. | Gupta N | BMJ (Clinical research ed.) | 2014 | |
| Improving delirium care for hospitalized older patients. A qualitative study identifying barriers to guideline adherence. | van de Steeg L, Langelaan M, Ijkema R, Nugus P, Wagner C | Journal of evaluation in clinical practice | 2014 | |
| A prospective observational study to investigate the association between abnormal hand movements and delirium in hospitalised older people. | Holt R, Teale EA, Mulley GP, Young J | Age and ageing | 2015 |
Aged, 80 and over, Delirium, diagnosis, England, Female, Geriatric Assessment, Hand, innervation, Hospital Mortality, Hospitalization, Hospitals, General, Humans, Inpatients, Male, Motor Activity, Predictive Value of Tests, Prospective Studies, Time Factors |
| Prevalence of delirium in opium users after coronary artery bypass graft surgery. | Eizadi-Mood N, Aghadavoudi O, Najarzadegan MR, Fard MM | International journal of preventive medicine | 2014 | |
| Delirium and hypovitaminosis D: neuroimaging findings. | Bourgeois JA, Hategan A, Ford J, Tisi DK, Xiong GL | The Journal of neuropsychiatry and clinical neurosciences | 2015 | |
| Tryptophan supplementation and postoperative delirium-a randomized controlled trial. | Robinson TN, Dunn CL, Adams JC, Hawkins CL, Tran ZV, Raeburn CD, Moss M | Journal of the American Geriatrics Society | 2014 | |
| Cerebrospinal fluid markers of neuroinflammation in delirium: A role for interleukin-1β in delirium after hip fracture. | Cape E, Hall RJ, van Munster BC, de Vries A, Howie SE, Pearson A, Middleton SD, Gillies F, Armstrong IR, White TO, Cunningham C, de Rooij SE, MacLullich AM | Journal of psychosomatic research | 2014 | |
| Association between combative behavior requiring intervention and delirium in hospitalized patients. | Uldall K, Williams BL, Dunn JD, Blackmore CC | Journal of hospital medicine : an official publication of the Society of Hospital Medicine | 2014 | |
| Recognition and management of delirium among doctors, nurses, physiotherapists, and psychologists: an Italian survey. | Bellelli G, Morandi A, Zanetti E, Bozzini M, Lucchi E, Terrasi M, Trabucchi M | International psychogeriatrics / IPA | 2014 | |
| A nationwide study on delirium in psychiatric patients from 1995 to 2011. | Lundberg AS, Okkels N, Gustafsson LN, Larsen JT, Sørensen LU, Munk-Jørgensen P | Acta neuropsychiatrica | 2014 | |
| Changing perspectives on delirium care: The new Dutch guideline on delirium. | Leentjens AF, Molag ML, Van Munster BC, De Rooij SE, Luijendijk HJ, Vochteloo AJ, Dautzenberg PL, | Journal of psychosomatic research | 2014 | |
| The Relationship Between a Chief Complaint of "Altered Mental Status" and Delirium in Older Emergency Department Patients. | Han JH, Schnelle JF, Ely EW | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine | 2014 | |
| Promoting Sleep in the Adult Surgical Intensive Care Unit Patients to Prevent Delirium. | Hata RK, Han L, Slade J, Miyahira A, Passion C, Ghows M, Izumi K, Yu M | The Nursing clinics of North America | 2014 | |
| Experience in delirium: is it distressing? | Grover S, Ghosh A, Ghormode D | The Journal of neuropsychiatry and clinical neurosciences | 2015 | |
| Delirium detection using EEG: what and how to measure. | van der Kooi AW, Zaal IJ, Klijn FA, Koek HL, Meijer RC, Leijten FS, Slooter AJ | Chest | 2015 | |
| Efficacy and safety of haloperidol prophylaxis for delirium prevention in older medical and surgical at-risk patients acutely admitted to hospital through the emergency department: study protocol of a multicenter, randomised, double-blind, placebo-control | Schrijver EJ, de Vries OJ, Verburg A, de Graaf K, Bet PM, van de Ven PM, Kamper AM, Diepeveen SH, Anten S, Siegel A, Kuipéri E, Lagaay AM, van Marum RJ, van Strien AM, Boelaarts L, Pons D, Kramer MH, Nanayakkara PW | BMC geriatrics | 2014 | |
| Do stress markers and anesthetic technique predict delirium in the elderly? | Deiner S, Lin HM, Bodansky D, Silverstein J, Sano M | Dementia and geriatric cognitive disorders | 2014 | |
| Hospital delirium and psychological distress at 1 year and health-related quality of life after moderate-to-severe traumatic injury without intracranial hemorrhage. | Abraham CM, Obremskey WT, Song Y, Jackson JC, Ely EW, Archer KR | Archives of physical medicine and rehabilitation | 2014 |
Adult, Delirium, psychology, Depression, epidemiology, Female, Follow-Up Studies, Hospitalization, Humans, Intensive Care Units, Male, Middle Aged, Psychiatric Status Rating Scales, Quality of Life, psychology, Stress Disorders, Post-Traumatic, epidemiology, Time Factors, Trauma Severity Indices, Wounds and Injuries, psychology |
| Recognizing changes in cognition in sub types of acute confusional state. | Mushtaq R, Shoib S, Shah T, Dar MM, Mushtaq S | Journal of clinical and diagnostic research : JCDR | 2014 | |
| Delirium in patients with cancer: assessment, impact, mechanisms and management. | Lawlor PG, Bush SH | Nature reviews. Clinical oncology | 2015 | |
| Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial. | de Jonghe A, van Munster BC, Goslings JC, Kloen P, van Rees C, Wolvius R, van Velde R, Levi M, de Haan RJ, de Rooij SE, | CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne | 2014 |
Aged, Aged, 80 and over, Arthroplasty, Replacement, Hip, adverse effects, Delirium, epidemiology, Double-Blind Method, Female, Fracture Fixation, Internal, adverse effects, Hip Fractures, complications, Humans, Incidence, Male, Melatonin, therapeutic use |
| Short-term cognitive effects after recovery from a delirium in a hospitalized elderly sample. | Mark RE, Muselaers N, Scholten H, van Boxtel A, Eerenberg T | The Journal of nervous and mental disease | 2014 |
Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Comorbidity, Cross-Sectional Studies, Delirium, complications, Dementia, epidemiology, Diabetes Mellitus, epidemiology, Executive Function, physiology, Female, Geriatric Assessment, Hospitalization, Humans, Male, Neuropsychological Tests, Recovery of Function, physiology, Time Factors |
| Sleep-disordered breathing is a risk factor for delirium after cardiac surgery: a prospective cohort study. | Roggenbach J, Klamann M, von Haken R, Bruckner T, Karck M, Hofer S | Critical care (London, England) | 2014 | |
| Haloperidol, risperidone, olanzapine and aripiprazole in the management of delirium: A comparison of efficacy, safety, and side effects. | Boettger S, Jenewein J, Breitbart W | Palliative & supportive care | 2014 | |
| Delirium and severe illness: Etiologies, severity of delirium and phenomenological differences. | Boettger S, Jenewein J, Breitbart W | Palliative & supportive care | 2015 |
Adult, Aged, Aged, 80 and over, Critical Illness, nursing, Delirium, diagnosis, Dementia, diagnosis, Female, Humans, Karnofsky Performance Status, Male, Middle Aged, Neoplasms, complications, Severity of Illness Index |
| Delirium in advanced age and dementia: A prolonged refractory course of delirium and lower functional status. | Boettger S, Jenewein J, Breitbart W | Palliative & supportive care | 2014 | |
| ICU delirium: A survey into nursing and medical staff knowledge of current practices and perceived barriers towards ICU delirium in the intensive care unit. | Elliott SR | Intensive & critical care nursing : the official journal of the British Association of Critical Care Nurses | 2014 | |
| Perioperative gabapentin and delirium following total knee arthroplasty: a post-hoc analysis of a double-blind randomized placebo-controlled trial. | Dighe K, Clarke H, McCartney CJ, Wong CL | Canadian journal of anaesthesia = Journal canadien d'anesthésie | 2014 | |
| ICU architectural design affects the delirium prevalence: a comparison between single-bed and multibed rooms*. | Caruso P, Guardian L, Tiengo T, Dos Santos LS, Junior PM | Critical care medicine | 2014 |
Cancer Care Facilities, standards, Delirium, epidemiology, Female, Hospital Bed Capacity, 100 to 299, Hospital Design and Construction, standards, Hospitals, Teaching, standards, Humans, Intensive Care Units, standards, Male, Middle Aged, Patients’ Rooms, standards, Prevalence, Retrospective Studies, Risk Factors |
| Evaluation of the Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle: Several Confounders to be Considered. | Yang L, Ye L, Zheng Z, Zhang M | Critical care medicine | 2014 | |
| Community-based rehabilitation post hospital discharge interventions for older adults with cognitive impairment following a hip fracture: a systematic review protocol. | van Wyk PM, Chu CH, Babineau J, Puts M, Brooks D, Saragosa M, McGilton KS | JMIR research protocols | 2014 | |
| Delirium transitions in the medical ICU: exploring the role of sleep quality and other factors. | Kamdar BB, Niessen T, Colantuoni E, King LM, Neufeld KJ, Bienvenu OJ, Rowden AM, Collop NA, Needham DM | Critical care medicine | 2015 |
Age Factors, Aged, Delirium, etiology, Female, Humans, Hypnotics and Sedatives, adverse effects, Intensive Care Units, statistics & numerical data, Male, Middle Aged, Questionnaires, Respiration, Artificial, adverse effects, Risk Factors, Sex Factors, Sleep, Sleep Deprivation, complications |
| Pain, delirium, and physical function in skilled nursing home patients with dementia. | Kolanowski A, Mogle J, Fick DM, Hill N, Mulhall P, Nadler J, Colancecco E, Behrens L | Journal of the American Medical Directors Association | 2015 | |
| Effect of the overlap syndrome of depressive symptoms and delirium on outcomes in elderly adults with hip fracture: a prospective cohort study. | Radinovic KS, Markovic-Denic L, Dubljanin-Raspopovic E, Marinkovic J, Jovanovic LB, Bumbasirevic V | Journal of the American Geriatrics Society | 2014 | |
| Prospective observational study of delirium recovery trajectories and associated short-term outcomes in older adults admitted to a specialized delirium unit. | Lam CY, Tay L, Chan M, Ding YY, Chong MS | Journal of the American Geriatrics Society | 2014 | |
| Risk factors for delirium in older trauma patients admitted to the surgical intensive care unit. | Bryczkowski SB, Lopreiato MC, Yonclas PP, Sacca JJ, Mosenthal AC | The journal of trauma and acute care surgery | 2014 |
Age Factors, Aged, Brain Injuries, complications, Delirium, etiology, Female, Glasgow Coma Scale, Humans, Injury Severity Score, Intensive Care Units, statistics & numerical data, Male, Middle Aged, Prospective Studies, Risk Factors, Substance-Related Disorders, complications, Thoracic Injuries, complications, Wounds and Injuries, complications |
| A systematic review of risk factors for delirium in the ICU. | Zaal IJ, Devlin JW, Peelen LM, Slooter AJ | Critical care medicine | 2015 |
APACHE, Acidosis, complications, Adult, Age Factors, Coma, complications, Critical Illness, therapy, Delirium, etiology, Dementia, complications, Female, Humans, Hypertension, complications, Intensive Care, statistics & numerical data, Intensive Care Units, statistics & numerical data, Male, Respiration, Artificial, adverse effects, Risk Factors, Wounds and Injuries, complications |
| Delirium-biomarkers and genetic variance. | Stoicea N, McVicker S, Quinones A, Agbenyefia P, Bergese SD | Frontiers in pharmacology | 2014 | |
| Geriatric syndromes in individuals admitted to vascular and urology surgical units. | McRae PJ, Peel NM, Walker PJ, de Looze JW, Mudge AM | Journal of the American Geriatrics Society | 2014 |
Accidental Falls, statistics & numerical data, Aged, Cardiology, Cohort Studies, Delirium, epidemiology, Female, General Surgery, Hospital Units, Humans, Incidence, Male, Patient Admission, Pressure Ulcer, epidemiology, Retrospective Studies, Syndrome, Urology |
| Multidimensional frailty score for the prediction of postoperative mortality risk. | Kim SW, Han HS, Jung HW, Kim KI, Hwang DW, Kang SB, Kim CH | JAMA surgery | 2014 |
Activities of Daily Living, Aged, Aged, 80 and over, Body Composition, Comorbidity, Delirium, complications, Dementia, complications, Female, Frail Elderly, Geriatric Assessment, Humans, Length of Stay, statistics & numerical data, Male, Nutritional Status, Postoperative Complications, mortality, Predictive Value of Tests, Republic of Korea, epidemiology, Risk Factors, Skilled Nursing Facilities, utilization, Surgical Procedures, Elective, mortality |
| Pain assessment in hospitalized older adults with dementia and delirium. | Paulson CM, Monroe T, Mion LC | Journal of gerontological nursing | 2014 |
Aged, Aged, 80 and over, Chronic Pain, diagnosis, Delirium, psychology, Dementia, psychology, Female, Geriatric Assessment, Hospitalization, Humans, Pain Measurement |
| Changes in gait variability with anti-dementia drugs: a systematic review and meta-analysis. | Beauchet O, Launay CP, Allali G, Annweiler C | CNS drugs | 2014 | |
| Precipitating factors of delirium: Stress response to multiple triggers among patients with and without dementia. | Hölttä EH, Laurila JV, Laakkonen ML, Strandberg TE, Tilvis RS, Pitkala KH | Experimental gerontology | 2014 | |
| Intraoperative dexamethasone and delirium after cardiac surgery: a randomized clinical trial. | Sauër AM, Slooter AJ, Veldhuijzen DS, van Eijk MM, Devlin JW, van Dijk D | Anesthesia and analgesia | 2014 | |
| Predisposing risk factors for delirium in living donor liver transplantation patients in intensive care units. | Wang SH, Wang JY, Lin PY, Lin KH, Ko CJ, Hsieh CE, Lin HC, Chen YL | PloS one | 2014 | |
| Statins and delirium during critical illness: a multicenter, prospective cohort study. | Morandi A, Hughes CG, Thompson JL, Pandharipande PP, Shintani AK, Vasilevskis EE, Han JH, Jackson JC, Laskowitz DT, Bernard GR, Ely EW, Girard TD | Critical care medicine | 2014 | |
| An early prediction of delirium in the acute phase after stroke. | Oldenbeuving AW, de Kort PL, van Eck van der Sluijs JF, Kappelle LJ, Roks G | Journal of neurology, neurosurgery, and psychiatry | 2014 |
Adult, Age Factors, Aged, Aged, 80 and over, Cognition Disorders, complications, Delirium, complications, Female, Humans, Infection, complications, Logistic Models, Male, Middle Aged, Prognosis, Risk Factors, Sensitivity and Specificity, Severity of Illness Index, Stroke, complications |
| Clinical practice guidelines for delirium management: potential application in palliative care. | Bush SH, Bruera E, Lawlor PG, Kanji S, Davis DH, Agar M, Wright DK, Hartwick M, Currow DC, Gagnon B, Simon J, Pereira JL | Journal of pain and symptom management | 2014 | |
| Reduction of intensive care unit length of stay: the case of early mobilization. | Hunter A, Johnson L, Coustasse A | The health care manager | 2014 | |
| Analgesic, sedative, antipsychotic, and neuromuscular blocker use in Canadian intensive care units: a prospective, multicentre, observational study. | Burry LD, Williamson DR, Perreault MM, Rose L, Cook DJ, Ferguson ND, Lapinsky SC, Mehta S | Canadian journal of anaesthesia = Journal canadien d'anesthésie | 2014 | |
| Diagnostic and treatment practices of delirium in a general hospital. | Rooney S, Qadir M, Adamis D, McCarthy G | Aging clinical and experimental research | 2014 | |
| Preoperative plasma leptin levels predict delirium in elderly patients after hip fracture surgery. | Chen XW, Shi JW, Yang PS, Wu ZQ | Peptides | 2014 | |
| Incidence and risk factors of delirium in patients post pancreaticoduodenectomy. | Gallagher TK, McErlean S, O'Farrell A, Hoti E, Maguire D, Traynor OJ, Conlon KC, Geoghegan JG | HPB : the official journal of the International Hepato Pancreato Biliary Association | 2014 | |
| Validity and reliability of the Thai version of the confusion assessment method. | Charoensak S, Thunmanurukkit A, Sittironnarit G, Sartra T | Journal of the Medical Association of Thailand = Chotmaihet thangphaet | 2014 |
Adult, Aged, Aged, 80 and over, Algorithms, Confusion, diagnosis, Delirium, diagnosis, Female, Humans, Male, Mental Status Schedule, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Reproducibility of Results, Thailand |
| Comparison of restrictive and liberal transfusion strategy on postoperative delirium in aged patients following total hip replacement: a preliminary study. | Fan YX, Liu FF, Jia M, Yang JJ, Shen JC, Zhu GM, Zhu SH, Li WY, Yang JJ, Ji MH | Archives of gerontology and geriatrics | 2014 | |
| Acute confusional state/delirium: An etiological and prognostic evaluation. | Rai D, Garg RK, Malhotra HS, Verma R, Jain A, Tiwari SC, Singh MK | Annals of Indian Academy of Neurology | 2014 | |
| Neurologic aspects of palliative care: the end of life setting. | Sizoo EM, Grisold W, Taphoorn MJ | Handbook of clinical neurology | 2014 |
Advance Care Planning, Grief, Humans, Movement Disorders, physiopathology, Nervous System Diseases, physiopathology, Palliative Care, Resuscitation Orders, Terminal Care, psychology |
| Effectiveness of melatonin for sundown syndrome and delirium. | de Jonghe A, van Munster BC, de Rooij SE | Journal of the American Geriatrics Society | 2014 |
Alzheimer Disease, complications, Delirium, drug therapy, Humans, Male, Melatonin, administration & dosage |