What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Effect of clock rhythm on emergence agitation and early postoperative delirium in older adults undergoing thoracoscopic lung cancer surgery: protocol for a prospective, observational, cohort study | Jiang, L. Wang, J. Chen, W. Wang, Z. Xiong, W. | BMC Geriatr | 2024 |
Humans |
| Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders | Arnsten, A. F. T. Ishizawa, Y. Xie, Z. | Mol Psychiatry | 2023 |
Humans |
| The role of perioperative sedative anesthetics in preventing postoperative delirium: a systematic review and network-meta analysis including 6679 patients | Huang, J. X. Zhang, S. S. Wang, S. X. Xi, D. S. Luo, F. R. Liu, C. J. Li, H. | BMC Cardiovasc Disord | 2024 |
PMID: 38448835 PMCID: PMC10916082 |
| Preventive Effects of Melatonin on Delirium in Intensive Care Unit Patients: A Meta-Analysis of Randomized Controlled Trials | Zhao, L. Feng, Z. Wang, Q. Jiang, Z. Qiu, X. | Altern Ther Health Med | 2024 |
ICU Delirium Melatonin Length of Stay Meta-Analysis Mechanical Ventilation |
| Mitochondrial Dysfunction of Peripheral Platelets as a Predictive Biomarker for Postoperative Delirium in Elderly Patients | Yang, Y. Zhang, W. Liu, Y. Liu, X. Xie, J. Xu, R. Huang, Y. Hao, J. Sun, Y. Gu, X. Ma, Z. | Ann Neurol | 2024 |
Postoperative Delirium Bioenergetic Health Index Surgery Mitochondria MMSE
|
| Effect of Esketamine on Postoperative Delirium in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass: A Randomized Controlled Trial | Xiong, X. Shao, Y. Chen, D. Chen, B. Lan, X. Shi, J. | Anesth Analg | 2024 |
Postoperative Delirium Esketamine Cardiac Valve Replacement Cardiopulmonary Bypass CAM CAM-ICU MMSE |
| Prolonged Hourly Neurologic Examinations are Associated with Increased Delirium and No Discernible Benefit in Mild/Moderate Geriatric Traumatic Brain Injury | Ruiz, R. A. F. Canas, M. Diaz, L. Aldana, J. A. Afzal, H. Falcon, A. F. Del Toro, D. Day, A. McCarthy, J. Stansfield, K. Bochicchio, G. V. Niziolek, G. Kranker, L. M. Rosengart, M. R. Hoofnagle, M. Leonard, J. | J Trauma Acute Care Surg | 2024 |
NeuroChecks Delirium TBI CAM-ICU |
| Association of Intravenous Neostigmine and Anticholinergics or Sugammadex with Postoperative Delirium: A Retrospective Cohort Study | Rössler, J. Abramczyk, E. Paredes, S. Anusic, N. Pu, X. Maheshwari, K. Turan, A. Ruetzler, K. | Anesth Analg | 2024 |
bCAM Postoperative Delirium Sugammadex Neostigmine Anesthesia Noncardiac Surgery |
| Metformin Use in Type 2 Diabetics and Delirium After Noncardiac Surgery: A Retrospective Cohort Analysis | Paredes, S. Harb, A. Rössler, J. Nikoo, M. Z. Ruetzler, K. Turan, A. Pu, X. Sessler, D. I. | Anesth Analg | 2024 |
Type 2 Diabetes CAM-ICU bCAM Postoperative Delirium Metformin
|
| Preoperative Intrathecal Morphine is Associated With Reduced Postoperative Pain, Agitation, and Delirium In Living Donor Kidney Transplantation Recipients | Lee, J. E. Lee, K. W. Gil, E. Park, J. B. Kim, B. J. Kim, H. Y. Kim, G. S. | Transplant Proc | 2024 |
Kidney Transplant Postoperative Delirium Intrathecal Morphine CAM-ICU Postoperative Pain Anesthesia |
| Neuropsychological follow-up of isoflurane sedated intensive care patients: a substudy of a randomized trial | Fuchs, V. F. Simon, H. V. Soldinger, N. Volk, T. Meiser, A. | Minerva Anestesiol | 2024 |
Critical care Isoflurane Propofol Delirium |
| Feasibility and Acceptability of Using Wireless Limited Polysomnography to Capture Sleep Before, During, and After Hospitalization for Patients With Planned Cardiothoracic Surgery | Cordoza, M. L. Anderson, B. J. Cevasco, M. Diamond, J. M. Younes, M. Gerardy, B. Iroegbu, C. Riegel, B. | J Cardiovasc Nurs | 2024 |
Critical Illness Intensive Care Unit Polysomnography Sleep Thoracic Surgery |
| Antipsychotics in the Treatment of Delirium in Critically Ill Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Carayannopoulos, K. L. Alshamsi, F. Chaudhuri, D. Spatafora, L. Piticaru, J. Campbell, K. Alhazzani, W. Lewis, K. | Crit Care Med | 2024 |
Antipsychotic medication Delirium Systematic review Critically Ill Cognitive Impairment Coma |
| Burnout and perceived burden levels related to delirium in physicians and nurses | Yamagata, H. Takihara, T. Kobayashi, R. Hirose, K. Higuchi, K. Miyahara, M. Komatsu, D. | Gen Hosp Psychiatry | 2024 |
Humans |
| Bell's mania as a clinical presentation in a neurosurgical setting from a tertiary care neuropsychiatric hospital in India | Mamtani, H. Utagi, S. Chaurasia, K. K. Reddy, P. V. Arasappa, R. Prasad, C. Srinivas, D. Rao, M. B. Thippeswamy, H. | Indian J Psychiatry | 2024 |
Craniopharyngioma |
| Correlation analysis between plasma biomarkers albumin, fibrinogen, and their ratio with postoperative delirium in patients undergoing non-cardiac surgery: a systematic review and meta-analysis | Lu, Z. Wang, B. Liu, M. Yu, D. Li, J. | Am J Transl Res | 2024 |
Albumin |
| Risk factors for hypoactive delirium in patients with nontraumatic ARDS: a prospective observational study | Lian, F. Li, F. Tang, X. Yuan, Y. | Sci Rep | 2024 |
Humans |
| Current Practices and Attitudes of Cardiac Nurses Regarding Cognitive Screening in Patients With Acute Coronary Syndrome | Zhao, E. Lowres, N. Bloomfield, J. Weddell, J. Tofler, G. Gallagher, R. | Heart Lung Circ | 2024 |
Acute coronary syndrome |
| Related factors of delirium after transsphenoidal endoscopic pituitary adenoma resection-A matched retrospective cohort study | Zhang, S. Chen, Y. Wang, X. Liu, J. Chen, Y. Zhang, G. | J Clin Neurosci | 2024 |
Neuroendoscopy |
| Prevalence of post-stroke delirium in acute settings: A systematic review and meta-analysis | Ye, F. Ho, M. H. Lee, J. J. | Int J Nurs Stud | 2024 |
Acute setting |
| Predictive factors for postoperative delirium in thoracic surgery | Yaguchi, T. Ichinokawa, H. Kirino, E. Suzuki, M. Komori, K. Matsunaga, T. Takamochi, K. Suzuki, K. | Gen Thorac Cardiovasc Surg | 2024 |
Postoperative delirium |
| Preoperative cognitive impairment and postoperative delirium among Holocaust survivors who achieved longevity | Weiss, Y. Zarour, S. Kiselevich, Y. Abu Ghanim, M. Hikry, D. Sinai Brzezinski, I. Zac, L. Cohen, B. Matot, I. | J Am Geriatr Soc | 2024 |
Holocaust |
| Substance use problems and disorders among adults 50 years and older receiving mental health treatment for a primary neurocognitive disorder | Ware, O. D. Baik, S. Becker, T. D. Neukrug, H. Zimmerman, S. | Aging Ment Health |
Aging |
|
| The risk of delirium after sedation with propofol or midazolam in intensive care unit patients | van Gelder, T. G. van Diem-Zaal, I. J. Dijkstra-Kersten, S. M. A. de Mul, N. Lalmohamed, A. Slooter, A. J. C. | Br J Clin Pharmacol | 2024 |
critical care |
| Incidence and Risk Factors for ICU-Associated Delirium in the Alert Geriatric Trauma Population | Ulderich Williams, S. C. Qaddoumi, A. I. Meghreblian, J. T. McBride, M. E. King, S. A. Elahi, M. A. Tuggle, D. Heidel, R. E. Smith, L. M. | Am Surg | 2024 |
Glasgow Coma Score |
| Opioid use and subsequent delirium risk in patients with advanced cancer in palliative care: a multicenter registry study | Yoo, S. H. Kang, J. Kim, H. J. Lee, S. W. Hong, M. Jung, E. H. Kim, Y. J. Yon, D. K. Kang, B. | Sci Rep | 2024 |
Humans |
| Point prevalence and clinical profile of patients with delirium admitted in internal medicine department at tertiary care centre in eastern Nepal: a descriptive cross-sectional study | Yogi, T. N. Puri, S. Shah, B. Nepal, S. Mishra, A. | Ann Med Surg (Lond) | 2024 |
alcoholism |
| Reducing the use of psychotropics in a convalescent rehabilitation ward | Uematsu, T. Tomita, T. Obara, R. Gonai, T. Hattori, K. Aonuma, T. Usui, K. Tanifuji, H. Ishizawa, F. Ishii, H. Suzuki, E. | Neuropsychopharmacol Rep | 2024 |
Humans |
| The impact of postoperative agitated delirium on dementia in surgical patients | Sun, M. Chen, W. M. Wu, S. Y. Zhang, J. | Brain Commun | 2024 |
Psm |
| The impact of postoperative agitated delirium on dementia in surgical patients | Sun, M. Chen, W. M. Wu, S. Y. Zhang, J. | Brain Commun | 2024 |
Psm |
| Effects of human herpesvirus 6B reactivation on cognitive function in cord blood transplant recipients: a prospective multicenter study | Ogata, M. Oshima, K. Takano, K. Kawano, R. Ueda, Y. Imamura, T. Nakamura, Y. Okada, T. Toubai, T. Ueki, T. Uoshima, N. Ishida, H. Shinohara, A. Seo, S. Fukuda, T. Inagaki, M. | Int J Hematol | 2024 |
Humans |
| Modification in ICU Design May Affect Delirium and Circadian Melatonin: A Proof of Concept Pilot Study | Spies, C. Piazena, H. Deja, M. Wernecke, K. D. Willemeit, T. Luetz, A. | Crit Care Med | 2024 |
Adult |
| The effect of nonpharmacological interventions applied by nurses to intensive care patients on the duration of delirium: a meta-analysis study | Söylemez, G. K. Uzun, S. | Ir J Med Sci | 2024 |
Humans |
| Prevalence, risk factors and impact of delirium in adult inpatients in a tertiary care hospital: A point prevalence study | Schiess, C. Hofer, L. Von Felten, S. Bartussek, J. Petry, H. Ernst, J. | J Clin Nurs | 2024 |
cross-sectional studies |
| The association between cerebral blood flow variations during on-pump coronary artery bypass grafting surgery and postoperative delirium | Sampaolesi, C. Casarotta, E. Gresti, G. Mariotti, G. Pisani, L. Veccia, D. Di Eusanio, M. Malvindi, P. G. Donati, A. Münch, C. M. | Perfusion | 2024 |
cerebral blood flow |
| Correlation of Sedation Depth During Critical Care Transport and Hospitalization | Roginski, M. A. Carroll, M. C. Trautwein, M. L. Watkins, E. D. Esteves, A. M. | J Intensive Care Med | 2024 |
Adult |
| The Health Outcomes of a Telegeriatrics Follow-Up Model on Dementia Patients and Their Caregivers in Cairo | Mossad, N. A. Hamza, S. A. Wahba, H. M. F. Youssif, H. Y. Tolba, M. F. | Telemed J E Health | 2024 |
caregiver satisfaction |
| Protect the neck: Devastating outcomes of cervical spine fractures in the elderly | Mormol, J. Krech, L. Pounders, S. Fisk, C. Chapman, A. Karek, M. Hing, K. K. | Am J Surg | 2024 |
Aged |
| Prevalence of clinical electroencephalography findings in stroke patients with delirium | Mintz, N. B. Andrews, N. Pan, K. Bessette, E. Asaad, W. F. Sherif, M. Rubinos, C. Mahta, A. Girard, T. D. Reznik, M. E. | Clin Neurophysiol | 2024 |
Delirium |
| Insulin resistance and osteocalcin associate with the incidence and severity of postoperative delirium in elderly patients undergoing joint replacement | Mi, Y. Wen, O. Lei, Z. Ge, L. Xing, L. Xi, H. | Geriatr Gerontol Int | 2024 |
elderly patients |
| Single-channel qEEG characteristics distinguish delirium from no delirium, but not postoperative from non-postoperative delirium | Lodema, D. Y. Ditzel, F. L. Hut, S. C. A. van Dellen, E. Otte, W. M. Slooter, A. J. C. | Clin Neurophysiol |
Acute encephalopathy |
|
| A Mendelian randomization-based study of the causal relationship between leisure sedentary behavior and delirium | Liu, C. Lv, X. Meng, L. Li, J. Cao, G. | J Affect Disord | 2024 |
Causal relationship |
| Understanding family carer experiences and perceptions of engagement in delirium prevention and care for adults in hospital: Qualitative systematic review | Lee-Steere, K. Mudge, A. Liddle, J. Bennett, S. | J Clin Nurs | 2024 |
Adult |
| The use of the DOS and Delirium Prevalence: a quantitative longitudinal study at a Swiss-German central hospital | Lauffer-Vogt, S. U. Hediger, H. Lauener, S. K. Schubert, M. | Pflege | 2024 |
Female |
| Melatonin does not reduce delirium severity in hospitalized older adults: Results of a randomized placebo-controlled trial | Lange, P. W. Turbić, A. Soh, C. H. Clayton-Chubb, D. Lim, W. K. Conyers, R. Watson, R. Maier, A. B. | J Am Geriatr Soc | 2024 |
aged neurocognitive disorders |
| Immunological Analysis of Postoperative Delirium after Thoracic Aortic Surgery | Ko, H. Kayumov, M. Lee, K. S. Oh, S. G. Na, K. J. Jeong, I. S. | J Chest Surg | 2024 |
Aorta |
| Risk Factors for Postoperative Cognitive Decline After Orthopedic Surgery in Elderly Chinese Patients: A Retrospective Cohort Study | Li, X. Lai, H. Wang, P. Feng, S. Feng, X. Kong, C. Wu, D. Yin, C. Shen, J. Yan, S. Han, R. Liu, J. Ren, X. Li, Y. Tang, L. Xue, D. Zhao, Y. Huang, H. Li, X. Zhang, Y. Wang, X. Wang, C. Jin, P. Lu, S. Wang, T. Zhao, G. Wang, C. | Clin Interv Aging | 2024 |
Aged |
| Clinical Impact of the Implementation Strategies Used to Apply the 2013 Pain, Agitation/Sedation, Delirium or 2018 Pain, Agitation/Sedation, Delirium, Immobility, Sleep Disruption Guideline Recommendations: A Systematic Review and Meta-Analysis | Hume, N. E. Zerfas, I. Wong, A. Klein-Fedyshin, M. Smithburger, P. L. Buckley, M. S. Devlin, J. W. Kane-Gill, S. L. | Crit Care Med | 2024 |
Adult |
| Delirium and incident dementia in hospital patients in New South Wales, Australia: retrospective cohort study | Gordon, E. H. Ward, D. D. Xiong, H. Berkovsky, S. Hubbard, R. E. | Bmj | 2024 |
Male |
| Effect of subanesthetic dose of esketamine on postoperative pain in elderly patients undergoing laparoscopic gastrointestinal tumor Surgery:A prospective, double-blind, randomized controlled trial | Jing, Z. Han, Y. Li, Y. Zeng, R. Wu, J. Wang, Y. Jiang, P. | Heliyon | 2024 |
Analgesia |
| Predictive Ability of Amplitude Integrated Electroencephalography for Adverse Outcomes in Neonates with Sepsis-Associated Encephalopathy: A Cohort Study | Jain, P. Saini, S. S. Sahu, J. K. Madaan, P. Sundaram, V. Dutta, S. | Indian J Pediatr | 2024 |
Cerebral function monitor |
| Perioperative knowledge, self-efficacy and clinical practices related to postoperative delirium care in older people across geographical regions in Australia | Igwe, E. O. Nealon, J. O'Shaughnessy, P. Ormonde, C. Traynor, V. | Aust J Rural Health | 2024 |
Australia |
| A survey of non-consultant hospital doctors' perspectives, knowledge, and practices toward delirium in a large Irish hospital | Hassabo, M. Mc Cluskey, P. Browne, J. Ntlholang, O. | Ir J Med Sci | 2024 |
4at |
| Dynamic delirium - Nursing intervention to reduce delirium in patients critically Ill, a randomized control trial | Gómez Tovar, L. O. Henao Castaño, A. M. | Intensive Crit Care Nurs | 2024 |
Clinical Trial |
| Delirium is more common and associated with worse outcomes in Parkinson's disease compared to older adult controls: results of two prospective longitudinal cohort studies | Gerakios, F. Yarnall, A. J. Bate, G. Wright, L. Davis, D. Stephan, B. C. M. Robinson, L. Brayne, C. Stebbins, G. Taylor, J. P. Burn, D. J. Allan, L. M. Richardson, S. J. Lawson, R. A. | Age Ageing | 2024 |
Humans |
| Effectiveness of remimazolam in preventing postoperative delirium in elderly patients with proximal femoral fractures | Fujimoto, D. Obata, N. Mizobuchi, S. | J Anesth | 2024 |
Elderly |
| Association between body mass index and delirium incidence in critically ill patients: a retrospective cohort study based on the MIMIC-IV Database | Fu, J. Zhang, X. Zhang, G. Wei, C. Fu, Q. Gui, X. Ji, Y. Chen, S. | BMJ Open | 2024 |
Humans |
| Structural disconnectivity in postoperative delirium: A perioperative two-center cohort study in older patients | Fislage, M. Winzeck, S. Woodrow, R. Lammers-Lietz, F. Stamatakis, E. A. Correia, M. M. Preller, J. Feinkohl, I. Hendrikse, J. Pischon, T. Spies, C. D. Slooter, A. J. C. Winterer, G. Menon, D. K. Zacharias, N. | Alzheimers Dement | 2024 |
brain health |
| Effects of short-term preoperative intranasal dexmedetomidine plus conventional treatment on delirium following cardiac surgery in patients with sleep disorders | Fang, J. Yang, J. Zhai, M. Zhang, Q. Zhang, M. Xie, Y. | Perioper Med (Lond) | 2024 |
Cognitive function |
| The predictive value of confusion assessment method-intensive care unit and intensive care delirium screening checklist for delirium in critically ill patients in the intensive care unit: A systematic review and meta-analysis | Diao, Y. Yu, X. Zhang, Q. Chen, X. | Nurs Crit Care | 2024 |
Cam‐icu |
| Factors associated with disagreement between clinician app-based ultra-brief Confusion Assessment Method and reference standard delirium assessments | Dhliwayo, R. Trivedi, S. Ngo, L. Fick, D. M. Inouye, S. K. Boltz, M. Leslie, D. Husser, E. Shrestha, P. Marcantonio, E. R. | J Am Geriatr Soc | 2024 |
Humans |
| Cognitive disorders in advanced Parkinson's disease: challenges in the diagnosis of delirium | Daniels, C. Rodríguez-Antigüedad, J. Jentschke, E. Kulisevsky, J. Volkmann, J. | Neurol Res Pract | 2024 |
Cognition |
| Assessment and management of delirium in a tertiary hospital-Improvements in cognitive screening and use of non-pharmacological strategies with a multidisciplinary approach | Clarke, E. Newman, E. Dravid, M. Ricciardello, M. Jones, E. Caudle, K. Kilshaw, L. Hilmi, S. Flicker, L. | Australas J Ageing | 2024 |
Humans |
| Assessment of level of knowledge, attitude, and associated factors toward delirium among health professionals working in intensive care unit multicenter, cross-sectional study, Amhara region comprehensive specialized hospitals, Northwest Ethiopia, 2023 | Ayanaw Eyayu, R. Gudayu Zeleke, T. Chekol, W. B. Yaregal Melesse, D. Enyew Ashagrie, H. | Front Public Health | 2024 |
Humans |
| The evaluation of frequency and predictors of delirium and its short-term and long-term outcomes in hospitalized older adults' | Ajmera, Y. Paul, K. Khan, M. A. Kumari, B. Kumar, N. Chatterjee, P. Dey, A. B. Chakrawarty, A. | Asian J Psychiatr | 2024 |
Humans |
| The impact of ketamine on outcomes in critically ill patients: a systematic review with meta-analysis and trial sequential analysis of randomized controlled trials | Abdildin, Y. Tapinova, K. Nemerenova, A. Viderman, D. | Acute Crit Care | 2024 |
critical care |
| Spanish transcultural adaptation of the 4AT score for the evaluation of delirium in the emergency department: a prospective diagnostic test accuracy study | Morales-Puerto, M. Ruiz-Díaz, M. García-Mayor, S. León-Campos, Á Morales-Asencio, J. M. Canca-Sánchez, J. C. Gavira-Guerra, S. Toledo-Fernandez, C. Aranda-Gallardo, M. | BMC Nurs | 2024 |
4at |
| Face and content validity of a mobile delirium screening tool adapted for use in the medical setting (eDIS-MED): Welcome to the machine | Eeles, E. Tronstad, O. Teodorczuk, A. Flaws, D. Fraser, J. F. Dissanayaka, N. | Australas J Ageing | 2924 |
computerized adaptive testing |
| Social determinants of health and incident postoperative delirium: Exploring key relationships in the SAGES study | Arias, F. Dufour, A. B. Jones, R. N. Alegria, M. Fong, T. G. Inouye, S. K. | J Am Geriatr Soc | 2024 |
Humans |
| Combining biomarkers of BNIP3 L, S100B, NSE and accessible measures to prediction sepsis-associated encephalopathy: a prospective observational study | Zhang, N. Xie, K. Yang, F. Wang, Y. Yang, X. Zhao, L. | Curr Med Res Opin | 2024 |
Bnip3 l |
| Association between preoperative albumin levels and postoperative delirium in geriatric hip fracture patients | Wang, W. Yao, W. Tang, W. Li, Y. Lv, Q. Ding, W. | Front Med (Lausanne) | 2024 |
Pod |
| Antipsychotic Use for ICU Delirium and Associated Inflammatory Markers | Torbic, H. Chen, A. Lumpkin, M. Yerke, J. Mehkri, O. Abraham, S. Wang, X. Duggal, A. Scheraga, R. G. | J Intensive Care Med | 2024 |
Adult |
| Delirium is frequently underdiagnosed among older hospitalised patients despite available information in hospital medical records | Titlestad, I. Haugarvoll, K. Solvang, S. H. Norekvål, T. M. Skogseth, R. E. Andreassen, O. A. Årsland, D. Neerland, B. E. Nordrehaug, J. E. Tell, G. S. Giil, L. M. | Age Ageing | 2024 |
Humans |
| Factors associated with delirium in a real-world acute-care setting: analysis considering the interdependence of clinical variables with the frailty syndrome | Ticinesi, A. Parise, A. Delmonte, D. Coppi, C. Prati, B. Cerundolo, N. Guerra, A. Nouvenne, A. Meschi, T. | Eur Geriatr Med | 2024 |
Acute cerebral dysfunction |
| Increased IgA-mediated responses to the gut paracellular pathway and blood-brain barrier proteins predict delirium due to hip fracture in older adults | Thisayakorn, P. Thipakorn, Y. Tantavisut, S. Sirivichayakul, S. Vojdani, A. Maes, M. | Front Neurol | 2024 |
bacterial translocation |
| Association of peripheral B cells and delirium: combined single-cell sequencing and Mendelian randomization analysis | Tan, S. Pan, S. Wei, L. Chen, W. Pan, B. Kong, G. Chen, J. Xie, Y. | Front Neurol | 2024 |
B cell |
| Clinical Outcomes after Multivalve Surgery in Octogenarians: Evaluating the Need for a Paradigm Shift | Taghizadeh-Waghefi, A. Petrov, A. Arzt, S. Alexiou, K. Tugtekin, S. M. Matschke, K. Kappert, U. Wilbring, M. | J Clin Med | 2024 |
multivalve disease |
| Evaluating early lymphocyte-to-monocyte ratio as a predictive biomarker for delirium in older adult patients with sepsis: insights from a retrospective cohort analysis | Shi, X. Yang, L. Bai, W. Jing, L. Qin, L. | Front Med (Lausanne) | 2024 |
Mimic-iv |
| The Association of Preoperative Diabetes With Postoperative Delirium in Older Patients Undergoing Major Orthopedic Surgery: A Prospective Matched Cohort Study | Shang, Z. Jiang, Y. Fang, P. Zhu, W. Guo, J. Li, L. Liang, Y. Zhang, S. Ma, S. Mei, B. Fan, Y. Xie, Z. Shen, Q. Liu, X. | Anesth Analg | 2024 |
Postoperative delirium diabetes orthopedic surgery elective surgery 3D-CAM delirium severity
|
| The role of neurohospitalism in a specialized cardiovascular hospital | Serôdio, M. Magriço, M. Sobral-Pinho, A. Ventura, R. Serrazina, F. Cabral, G. Meira, B. Fernandes, M. Salavisa, M. Saraiva, M. Marto, J. P. Sá, F. Calado, S. Baptista, M. V. | Eur Neurol | 2024 |
Cardiovascular neurology delirium altered mental status AIS
|
| Bringing Delirium to Light: Impact of CAM-ICU Tool to Improve Care Coordination | Savino, T. Vergara, F. H. Ramos, M. D. Warzecha, D. | Prof Case Manag | 2024 |
Delirium CCU Early assessment CAM-ICU Length of Stay Case Management |
| Delirium and Its Associations with Critical Care Utilizations and Outcomes at the Time of Hospital Discharge in Patients with Acute Brain Injury | Raquer, A. P. Fong, C. T. Walters, A. M. Souter, M. J. Lele, A. V. | Medicina (Kaunas) | 2024 |
Humans |
| Data-derived subtypes of delirium during critical illness | Potter, K. M. Kennedy, J. N. Onyemekwu, C. Prendergast, N. T. Pandharipande, P. P. Ely, E. W. Seymour, C. Girard, T. D. | EBioMedicine | 2024 |
Adult |
| Infection, delirium, and risk of dementia in patients with and without white matter disease on previous brain imaging: a population-based study | Pendlebury, S. T. Luengo-Fernandez, R. Seeley, A. Downer, M. B. McColl, A. Rothwell, P. M. | Lancet Healthy Longev | 2024 |
United States |
| A novel risk assessment tool for postoperative delirium in vascular surgery: The stress model (Siena posTopeRative dElirium in vaScular Surgery) | Pasqui, E. de Donato, G. Brancaccio, B. Casilli, G. Ferrante, G. Palasciano, G. | Vascular | 2024 |
Vascular surgery |
| The Delphi Delirium Management Algorithms. A practical tool for clinicians, the result of a modified Delphi expert consensus approach | Ottens, T. H. Hermes, C. Page, V. Oldham, M. Arora, R. Bienvenu, O. J., 3rd van den Boogaard, M. Caplan, G. Devlin, J. W. Friedrich, M. E. van Gool, W. A. Hanison, J. Hansen, H. C. Inouye, S. K. Kamholz, B. Kotfis, K. Maas, M. B. MacLullich, A. M. J. Marc | Delirium (Bielef) | 2024 |
Clinical practice algorithm |
| Identification of early delirium and its outcomes after cardiopulmonary bypass among adult patients with cardiovascular disease: a prospective observational study | Othman, S. M. A. Xu, Q. Zhao, K. Kafi, L. Aziz, M. A. A. | Indian J Thorac Cardiovasc Surg | 2024 |
Bypass machine |
| Association between Preoperative Glucose Dysregulation and Delirium after Non-Cardiac Surgery | Oh, A. R. Lee, D. Y. Lee, S. Lee, J. H. Yang, K. Choi, B. Park, J. | J Clin Med | 2024 |
delirium |
| Epidural vs. systemic analgesia in the Intensive Care Unit: retrospective study of patient outcomes | Naser, A. Meyer, A. Ifrach, N. Dichtwald, S. | Minerva Anestesiol | 2024 |
Humans |
| Whole blood thiamine, intravenous thiamine supplementation and delirium occurrence in the intensive care unit: retrospective cohort analyses | Mumin, M. A. McKenzie, C. A. Page, V. J. Hadfield, D. Aitken, L. M. Hanks, F. Cunningham, E. Blackwood, B. Van Dellen, E. Slooter, A. J. C. Grocott, M. P. W. McAuley, D. F. Spronk, P. E. | Int J Clin Pharm | 2024 |
Critical care |
| Intraoperative Blood Pressure Management and Its Effects on Postoperative Delirium After Cardiac Surgery: A Single-Center Retrospective Cohort Study | Mohr, N. L. Krannich, A. Jung, H. Hulde, N. von Dossow, V. | J Cardiothorac Vasc Anesth | 2024 |
Ioh |
| Implementing pain, agitation, delirium, and sleep deprivation protocol in critically ill patients: A pilot study on pharmacological interventions | Luetrakool, P. Taesotikul, S. Susantitapong, K. Suthisisang, C. Morakul, S. Sutherasan, Y. Tangsujaritvijit, V. Dilokpattanamongkol, P. | Clin Transl Sci | 2024 |
Humans |
| An exploratory research report on brain mineralization in postoperative delirium and cognitive decline | Lammers-Lietz, F. Borchers, F. Feinkohl, I. Hetzer, S. Kanar, C. Konietschke, F. Lachmann, G. Chien, C. Spies, C. Winterer, G. Zaborszky, L. Zacharias, N. Paul, F. | Eur J Neurosci | 2024 |
anaesthesia |
| Delirium Severity and Physical Function in Hospitalized Persons Living With Dementia: Moderation by Age, Sex, and Race | Kuzmik, A. Boltz, M. Resnick, B. McPherson, R. Rodriguez, M. Drazich, B. F. Galik, E. | Alzheimer Dis Assoc Disord | 2024 |
Male |
| Effectiveness of antipsychotics for managing agitated delirium in patients with advanced cancer: a secondary analysis of a multicenter prospective observational study in Japan (Phase-R) | Kurisu, K. Inada, S. Maeda, I. Nobata, H. Ogawa, A. Iwase, S. Uchida, M. Akechi, T. Amano, K. Nakajima, N. Morita, T. Sumitani, M. Yoshiuchi, K. | Support Care Cancer | 2024 |
Humans |
| The spectrum of psychological disorders in family members of patients suffering from delirium associated with critical illness: a prospective, observational study | Kotfis, K. Maj, P. Szylińska, A. Pankowiak, M. Reszka, E. Ely, E. W. Marra, A. | Sci Rep | 2024 |
Adult |
| Impact of Prefracture Cognitive Impairment and Postoperative Delirium on Recovery After Hip Fracture Surgery | Kamimura, T. Kobayashi, Y. Tamaki, S. Koinuma, M. | J Am Med Dir Assoc | 2024 |
Cognitive impairment |
| Development of a Prediction Model for Delirium in Hospitalized Patients with Advanced Cancer | Jung, E. H. Yoo, S. H. Lee, S. W. Kang, B. Kim, Y. J. | Cancer Res Treat | 2024 |
Delirium |
| Nurses' Knowledge and Subjective Strain in Delirium Care: Impact of a Web-based Instructional Module on Nurses Competence | Jose, S. Cyriac, M. C. Dhandapani, M. | Indian J Crit Care Med | 2024 |
Delirium |
| Difficulties faced by intensive care nurses in caring for patients with delirium: A cross-sectional, multicentre study | Jiang, T. Tung, T. H. Wang, Y. Zheng, X. T. Jia, L. Zhang, W. | Aust Crit Care | 2024 |
Cross-sectional study |