What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
Title | Authors | Journal | Year | Keywords |
---|---|---|---|---|
A protocol of an international validation study to assess the clinical accuracy of the eDIS-ICU delirium screening tool | Tronstad, O. Patterson, S. Sutt, A. L. Pearse, I. Hay, K. Liu, K. Sato, K. Koga, Y. Matsuoka, A. Hongo, T. Rätsep, I. Fraser, J. F. Flaws, D. | Aust Crit Care | 2023 |
Humans |
Anaesthesia-related cognitive dysfunction following cardiothoracic surgery in late middle-age and younger adults: A scoping review | Varpaei, H. A. Robbins, L. B. Ling, J. Lehto, R. H. Bender, C. M. | Nurs Crit Care | 2023 |
anaesthesia |
Long-term mortality of critically ill patients with cancer and delirium who survived to discharge: a retrospective cohort study | Vizzacchi, B. A. Pezzini, T. R. de Souza, J. M. Caruso, P. Nassar, A. P., Jr. | Can J Anaesth | 2023 |
Adult |
The effect of anesthetic depth on postoperative delirium in older adults: a systematic review and meta-analysis | Wang, Y. Zhu, H. Xu, F. Ding, Y. Zhao, S. Chen, X. | BMC Geriatr | 2023 |
Humans |
Unveiling the nexus of postoperative fever and delirium in cardiac surgery: identifying predictors for enhanced patient care | Wang, Y. P. Shen, B. B. Zhu, C. C. Li, L. Lu, S. Wang, D. J. Jin, H. Liu, Q. Wang, Z. Y. Ge, M. | Front Cardiovasc Med | 2023 |
Cpb |
Long-term cognitive impairment after probable delirium in long-term care residents: A population-based retrospective cohort study | Webber, C. Milani, C. Pugliese, M. Lawlor, P. G. Bush, S. H. Watt, C. Casey, G. Knoefel, F. Thavorn, K. Momoli, F. Tanuseputro, P. | J Am Geriatr Soc | 2023 |
cognitive decline |
Delirium Due to Potentially Avoidable Hospitalizations Among Older Adults | Whittington, C. Skains, R. M. Zhang, Y. Osborne, J. D. O'Leary, T. Freeman, H. B. Martin, R. C. Vickers, J. K. Flood, K. L. Markland, A. D. Buford, T. W. Brown, C. J. Kennedy, R. E. | J Gerontol A Biol Sci Med Sci | 2023 |
ambulatory care sensitive conditions |
Quantitative electroencephalography predicts postoperative delirium in cardiac surgical patients after cardiopulmonary bypass: a prospective observational study | Xue, Y. Liu, W. Su, L. He, H. Chen, H. Long, Y. | Front Med (Lausanne) | 2023 |
cardiopulmonary bypass |
Natural language processing to assess the epidemiology of delirium-suggestive behavioural disturbances in critically ill patients | Young, M. Holmes, N. Robbins, R. Marhoon, N. Amjad, S. Neto, A. S. Bellomo, R. | Crit Care Resusc | 2021 |
Background: There is no gold standard approach for delirium diagnosis, making the assessment of its epidemiology difficult. Delirium can only be inferred though observation of behavioural disturbance and described with relevant nouns or adjectives. Objective: We aimed to use natural language processing (NLP) and its identification of words descriptive of behavioural disturbance to study the epidemiology of delirium in critically ill patients. Study design: Retrospective study using data collected from the electronic health records of a university-affiliated intensive care unit (ICU) in Melbourne, Australia. Participants: 12 375 patients Intervention: Analysis of electronic progress notes. Identification using NLP of at least one of a list of words describing behavioural disturbance within such notes. Results: We analysed 199 648 progress notes in 12 375 patients. Of these, 5108 patients (41.3%) had NLP-diagnosed behavioural disturbance (NLP-Dx-BD). Compared with those who did not have NLP-Dx-DB, these patients were older, more severely ill, and likely to have medical or unplanned admissions, neurological diagnosis, chronic kidney or liver disease and to receive mechanical ventilation and renal replacement therapy (P < 0.001). The unadjusted hospital mortality for NLP-Dx-BD patients was 14.1% versus 9.6% for patients without NLP-Dx-BD. After adjustment for baseline characteristics and illness severity, NLP-Dx-BD was not associated with increased risk of death (odds ratio [OR], 0.94; 95% CI, 0.80-1.10); a finding robust to multiple sensitivity, subgroups and time of observation subcohort analyses. In mechanically ventilated patients, NLP-Dx-BD was associated with decreased hospital mortality (OR, 0.80; 95% CI, 0.65-0.99) after adjustment for baseline severity of illness and year of admission. Conclusions: NLP enabled rapid assessment of large amounts of data identifying a population of ICU patients with typical high risk characteristics for delirium. Moreover, this technique enabled identification of previously poorly understood associations. Further investigations of this technique appear justified. |
Association between intraoperative mean arterial pressure variability and postoperative delirium after hip fracture surgery: a retrospective cohort study | Zhang, C. Song, Y. Wu, X. Miao, R. Lou, J. Ma, Y. Li, M. Mi, W. Cao, J. | BMC Geriatr | 2023 |
Aged |
Impact of Clinical Decision Support System Assisted prevention and management for Delirium on guideline adherence and cognitive load among Intensive Care Unit nurses (CDSSD-ICU): Protocol of a multicentre, cluster randomized trial | Zhang, S. Ding, S. Cui, W. Li, X. Wei, J. Wu, Y. | Int J Nurs Stud | 2023 |
Humans |
Non-pharmacological interventions to prevent and treat delirium in older people: An overview of systematic reviews | Zhao, Q. Liu, S. Zhao, H. Dong, L. Zhu, X. Liu, J. | Int J Nurs Stud | 2023 |
Humans |
Online interpretable dynamic prediction models for postoperative delirium after cardiac surgery under cardiopulmonary bypass developed based on machine learning algorithms: A retrospective cohort study | Zhao, X. Li, J. Xie, X. Fang, Z. Feng, Y. Zhong, Y. Chen, C. Huang, K. Ge, C. Shi, H. Si, Y. Zou, J. | J Psychosom Res | 2023 |
Cardiac surgery |
Dementia and Postoperative Delirium in Surgical Hip Fracture Patients: Unveiling Contrasting Risk Factors and Implications | Zhao, Y. Alderden, J. Missbrenner, N. | J Gerontol Nurs | 2023 |
Humans |
Diagnostic accuracy of the Family Confusion Assessment Method for delirium detection: A systematic review and meta-analysis | Zhou, C. Wang, H. Wang, L. Zhou, Y. Wu, Q. | J Am Geriatr Soc | 2023 |
Fam-cam |
The effects of a multidisciplinary pathway for perioperative management of patients with hip fracture | Ackermann, L. L. Schwenk, E. S. Li, C. J. Vaile, J. R. Weitz, H. | Hosp Pract (1995) | 2023 |
Humans, Aged, Analgesics, Opioid/therapeutic use, Prospective Studies |
Precision-based approaches to delirium in critical illness: A narrative review | Ankravs, M. J. McKenzie, C. A. Kenes, M. T. | Pharmacotherapy | 2023 |
Humans, Delirium/diagnosis/drug therapy/etiology, Intensive Care Units |
Associations between early in-hospital medications and the development of delirium in patients with stroke | Ryan, S. L. Liu, X. McKenna, V. Ghanta, M. Muniz, C. Renwick, R. Westover, M. B. Kimchi, E. Y. | J Stroke Cerebrovasc Dis | 2023 |
Humans |
Family-centered delirium prevention and treatment using video calls: the FACE Delirium trial | Trabert, J. Schenk, A. Golbach, R. Püllen, R. Schütze, S. | Eur Geriatr Med | 2023 |
Delirium |
Early Onset Delirium During Hospitalization Increases In-Hospital and Postdischarge Mortality in COVID-19 Patients: A Multicenter Prospective Study | Trevisan, C. Grande, G. Rebora, P. Zucchelli, A. Valsecchi, M. G. Focà, E. Ecarnot, F. Marengoni, A. Bellelli, G. | J Clin Psychiatry | 2023 |
Humans |
Accuracy of a clinical decision support system based on the 3-minute diagnostic interview for CAM-defined delirium: A validation study(✰) | Wang, J. Ji, M. Huang, Y. Yang, F. Wu, Y. | Geriatr Nurs | 2023 |
Humans |
Psychological stress and associated factors in caring for patients with delirium among intensive care unit nurses: A cross-sectional study | Wang, Y. Li, L. Tan, S. Guan, Y. Luo, X. | Aust Crit Care | 2023 |
Humans |
Inflammatory biomarkers and delirium: a Mendelian randomization study | Yu, M. Li, Y. Li, B. Ge, Q. | Front Aging Neurosci | 2023 |
Il-6
|
Knowledge, attitude and practice regarding hypoactive delirium among ICU nurses: A nationwide cross-sectional study | Yu, M. Mi, J. Zhang, C. Chen, H. Luo, X. | Nurse Educ Pract | 2023 |
Attitude |
Potentials of Acetylcholinesterase and Butyrylcholinesterase Alterations in On-Pump Coronary Artery Bypass Surgery in Postoperative Delirium: An Observational Trial | Zajonz, T. S. Kunzemann, C. Schreiner, A. L. Beckert, F. Schneck, E. Boening, A. Markmann, M. Sander, M. Koch, C. | J Clin Med | 2023 |
cardiac surgery |
Peripheral cholinesterase activity is not correlated with postoperative delirium in urological surgery | Zangl, Q. Sprinz, B. von Dossow, V. | J Perioper Pract | 2023 |
Acetylcholinesterase |
Biologic correlates associated with poor functional recovery after delirium: A nested prospective cohort study | Dasgupta, M. Brymer, C. | Health Sci Rep | 2023 |
activities of daily living |
ICU Delirium Is Associated with Cardiovascular Burden and Higher Mortality in Patients with Severe COVID-19 Pneumonia | Gutowski, M. Klimkiewicz, J. Michałowski, A. Ordak, M. Możański, M. Lubas, A. | J Clin Med | 2023 |
Covid-19 |
Analysis of risk factors for postoperative delirium in middle-aged and elderly fracture patients in the perioperative period | An, Z. Xiao, L. Chen, C. Wu, L. Wei, H. Zhang, X. Dong, L. | Sci Rep | 2023 |
Aged |
Korkatti-Puoskari, N. Tiihonen, M. Caballero-Mora, M. A. Topinkova, E. Szczerbińska, K. Hartikainen, S. | Therapeutic dilemma's: antipsychotics use for neuropsychiatric symptoms of dementia, delirium and insomnia and risk of falling in older adults, a clinical review | Eur Geriatr Med | 2023 |
Humans |
The efficacy and safety of haloperidol for the treatment of delirium in critically ill patients: a systematic review and meta-analysis of randomized controlled trials | Huang, J. Zheng, H. Zhu, X. Zhang, K. Ping, X. | Front Med (Lausanne) | 2023 |
Icu |
A prospective randomized study examining the impact of intravenous versus inhalational anesthesia on postoperative cognitive decline and delirium | Farrer, T. J. Monk, T. G. McDonagh, D. L. Martin, G. Pieper, C. F. Koltai, D. | Appl Neuropsychol Adult | 2023 |
Anesthesia type |
Factors Associated with Improvement in Activities of Daily Living during Hospitalization: A Retrospective Study of Older Patients with Hip Fractures | Takeda, K. Wada, M. Yorozuya, K. Hara, Y. Watanabe, T. Hanaoka, H. | Ann Geriatr Med Res | 2023 |
Activities of daily living |
Associations Between Dysphagia and Adverse Health Outcomes in Older Adults with Dementia in Intensive Care Units: A Retrospective Cohort Study | Cheng, H. Deng, X. Li, J. Tang, Y. Yuan, S. Huang, X. Wang, Z. Zhou, F. Lyu, J. | Clin Interv Aging | 2023 |
Humans |
Microvascular reconstruction for oral cancer in older adult patients: the impact of age on surgical outcomes | Kouketsu, A. Kaneuji, T. Yamaguma, Y. Yamauchi, K. Sugiura, T. Takahashi, T. Ito, H. Yamashita, Y. | Oral Surg Oral Med Oral Pathol Oral Radiol | 2023 |
oral, cancer, surgical, adults, elderly |
Postoperative delirium is a risk factor of institutionalization after hip fracture: an observational cohort study | Labaste, F. Delort, F. Ferré, F. Bounes, F. Reina, N. Valet, P. Dray, C. Minville, V. | Front Med (Lausanne) | 2023 |
delirium |
Prognostic significance of delirium in patients with heart failure: a systematic review and meta-analysis | Niu, Z. Zhou, J. Li, Y. | Front Cardiovasc Med | 2023 |
delirium |
Postoperative delirium in 47 379 individuals undergoing transcatheter aortic valve replacement: a systematic review and meta-analysis | Ochani, S. Adnan, A. Siddiqui, A. Kalwar, A. Kukreja, S. Ahmad, M. Ashraf, M. H. Asghar, M. A. | Ann Med Surg (Lond) | 2023 |
Cam, Tavr, confusion assessment method, delirium, stroke, transcatheter aortic valve replacement |
ICU Readmission in Injured Older Adults: Modifiable Risk Factors and Implications | Agoubi, L. L. Reimel, B. A. Maine, R. G. O'Connell, K. M. Maier, R. V. McIntyre, L. K. | J Trauma Acute Care Surg | 2023 |
ICU, delirium, older adults, risk factors, readmission |
Motorist disorientation syndrome; clinical features and vestibular findings | Ainsworth, C. Davies, R. Colvin, I. Murdin, L. | J Vestib Res | 2023 |
Humans |
External validity of an automated delirium prediction model (DEMO) and comparison to the manual VMS-questions: a retrospective cohort study | Ali, M. I. M. Kalkman, G. A. Wijers, C. H. W. Fleuren, Hwha Kramers, C. de Wit, Hajm | Int J Clin Pharm | 2023 |
Humans |
Role of Intraoperative Neuromonitoring to Predict Postoperative Delirium in Cardiovascular Surgery | Al-Qudah, A. M. Ta'ani, O. A. Thirumala, P. D. Sultan, I. Visweswaran, S. Nadkarni, N. Kiselevskaya, V. Crammond, D. J. Balzer, J. Anetakis, K. M. Shandal, V. Subramanium, K. Subramanium, B. Sadhasivam, S. | J Cardiothorac Vasc Anesth | 2023 |
Eeg, Ionm, Ssep, cardiac, delirium, postoperative |
Comparison of the hemodynamic effects of opioid-based versus lidocaine-based induction of anesthesia with propofol in older adults: a randomized controlled trial | Amin, S. M. Hasanin, A. ElSayed, O. S. Mostafa, M. Khaled, D. Arafa, A. S. Hassan, A. | Anaesth Crit Care Pain Med | 2023 |
Humans |
Effect of pharmacist-led intervention protocol on preventing postoperative delirium after elective cardiovascular surgery | Asai, Y. Yanagawa, T. Takahashi, M. | PLoS One | 2023 |
Adult, Humans, *Emergence Delirium, Pharmacists, Retrospective Studies, Benzodiazepines/adverse effects |
Taming Postoperative Delirium with Dexmedetomidine: A Review of the Therapeutic Agent's Neuroprotective Effects following Surgery | Bargnes, V., 3rd Oliver, B. Wang, E. Greenspan, S. Jin, Z. Yeung, I. Bergese, S. | Pharmaceuticals (Basel) | 2023 |
dexmedetomidine |
Level of implementation of pain management and early mobilization strategies to prevent delirium in geriatric trauma patients: A mixed-methods study | Beaudoin, M. Belzile, E. L. Gélinas, C. Trépanier, D. Émond, M. Gagnon, M. A. Bérubé, M. | Int J Orthop Trauma Nurs | 2023 |
Delirium, Early mobilization, Geriatric trauma, Mixed-methods, Pain management, Practice guidelines |
Dose-dependent QTc interval prolongation under haloperidol and pipamperone in the management of delirium in a naturalistic setting | Bohny, P. Boettger, S. Jenewein, J. | Front Psychiatry | 2023 |
QTc interval, delirium, haloperidol, pipamperone, torsades de pointes |
Prevalence and risk factors of subsyndromal delirium among postoperative patients: A systematic review and meta-analysis | Chen, S. Tang, L. Chen, J. Cai, L. Liu, C. Song, J. Chen, Y. Liu, Y. Zheng, S. | J Adv Nurs | 2023 |
Subsyndromal delirium, meta-analysis, nurse, nursing, postoperative care, prevalence, risk factors, surgery |
Incidence change of postoperative delirium after implementation of processed electroencephalography monitoring during surgery: a retrospective evaluation study | Chen, Y. C. Hung, I. Y. Hung, K. C. Chang, Y. J. Chu, C. C. Chen, J. Y. Ho, C. H. Yu, C. H. | BMC Anesthesiol | 2023 |
Humans |
Incidence and risk factors for postoperative delirium after head and neck cancer surgery: an updated meta-analysis | Dong, B. Yu, D. Jiang, L. Liu, M. Li, J. | BMC Neurol | 2023 |
Humans |
Five-year stroke prognosis. Influence of post-stroke delirium and post-stroke dementia on mortality and disability (Research Study - Part of the PROPOLIS Study) | Droś, J. Segiet, N. Początek, G. Klimkowicz-Mrowiec, A. | Neurol Sci | 2023 |
Cognition disorders, Delirium, Dementia, Mortality, Stroke |
Comparison of continuous sedatives in the burn ICU on delirium and coma | Falksen, J. Young, S. R. Lee, J. A. | J Burn Care Res | 2023 |
burn, coma, delirium, sedation |
Associations between depression symptom burden and delirium risk: a prospective cohort study | Gaba, A. Li, P. Xi, Z. Gao, C. Ruixue, C. Hu, K. Gao, L. | medRxiv | 2023 |
Altered mental status |
Delirium and Previous Psychiatric History Independently Predict Poststroke Posttraumatic Stress Disorder | Griffin, T. T. Bhave, V. McNulty, J. Christophe, B. R. Garton, A. L. A. Sander Connolly, E., Jr. | Neurologist | 2023 |
Humans, Female, *Stress Disorders, Post Traumatic/epidemiology/etiology/diagnosis, *Stroke/complications/epidemiology, *Delirium/diagnosis/epidemiology/etiology |
Incidence of Postoperative Delirium in Cancer Patients After Head and Neck Surgery: A Proportional Meta-analysis | Ho, M. H. Li, P. W. C. Lin, Y. K. Lee, J. J. Lin, C. C. | Otolaryngol Head Neck Surg | 2023 |
cancer, delirium, head and neck cancer, incidence, postoperative, proportional Meta-analysis |
Triglyceride-glucose index as a valuable predictor for aged 65-years and above in critical delirium patients: evidence from a multi-center study | Huang, X. Cheng, H. Yuan, S. Ling, Y. Tan, S. Tang, Y. Niu, C. Lyu, J. | BMC Geriatr | 2023 |
Humans |
Reliability and Validity of the Spanish Adaptation of the Stanford Proxy Test for Delirium in 2 Clinical Spanish-Speaking Communities | Infante, S. Behn, A. González, M. Pintor, L. Franco, E. Araya, P. Maldonado, J. R. | J Acad Consult Liaison Psychiatry | 2023 |
Stanford proxy test for delirium, confusion assessment method, delirium, delirium and COVID, factor analysis |
Association between preoperative neutrophil-lymphocyte ratio, uric acid, and postoperative delirium in elderly patients undergoing degenerative spine surgery | Kato, K. Kinoshita, H. Kumagai, G. Takekawa, D. Nitobe, Y. Asari, T. Wada, K. Kushikata, T. Ishibashi, Y. Hirota, K. | J Anesth | 2023 |
Neuroprotection, Neutrophil–lymphocyte ratio, Postoperative delirium, Spine surgery, Uric acid |
Preoperative assessment of postoperative delirium: a cross-sectional study of patients and anesthesiologists in Canada | Khaled, M. Youssef, N. Choi, S. Uppal, V. Chui, J. Marcucci, M. Madden, K. Shanthanna, H. | Can J Anaesth | 2023 |
Humans |
Resting-state prefrontal EEG biomarker in correlation with postoperative delirium in elderly patients | Kim, J. Park, S. Kim, K. N. Ha, Y. Shin, S. J. Cha, W. Lee, K. Y. Choi, J. Koo, B. N. | Front Aging Neurosci | 2023 |
elderly, electroencephalography, median dominant frequency, postoperative complications, postoperative delirium |
Risk of delirium with antiepileptic drug use: a study based on the Japanese Adverse Drug Event Report database | Kubo, T. Sogawa, R. Tsuruhashi, S. Murakawa-Hirachi, T. Matsuoka, A. Mizoguchi, Y. Monji, A. Shimanoe, C. | Int J Clin Pharm | 2023 |
Humans |
Optimizing delirium care in the era of Age-Friendly Health System | Kwak, M. J. Inouye, S. K. Fick, D. M. Bonner, A. Fulmer, T. Carter, E. Tabbush, V. Maya, K. Reed, N. Waszynski, C. Oh, E. S. | J Am Geriatr Soc | 2023 |
Age-Friendly Health System, Hospital Elder Life Program, delirium |
Risk factors for hyperactive delirium after laparoscopic radical gastrectomy under general anesthesia in patients with gastric cancer | Liu, J. Zhong, Q. Tan, H. Zhuo, M. Zhong, M. Cai, T. | Am J Transl Res | 2023 |
Laparoscopic radical gastrectomy, general anesthesia, hyperactive delirium, risk factors |
Risk factors associated with postoperative delirium in elderly patients undergoing hip surgery | Liu, X. H. Zhang, Q. F. Liu, Y. Lu, Q. W. Wu, J. H. Gao, X. H. Chen, Z. Y. | Front Psychiatry | 2023 |
Pacu |
The influence of delirium on mortality and length of ICU stay and analysis of risk factors for delirium after liver transplantation | Ma, Y. Li, C. Peng, W. Wan, Q. | ATS Sch | 2023 |
ICU stay |
Hyperactive delirium during emergency department stay: analysis of risk factors and association with short-term outcomes | Miró, Ò Osorio, G. Alquézar-Arbé, A. Aguiló, S. Fernández, C. Burillo, G. Jacob, J. Llorens, P. Llauger, L. Peláez González, Á Figuera Castro, E. R. Juarez González, R. Blanco Hoffman, M. J. Fernandez Salgado, F. Pablos Pizarro, T. Berenguer Dí | Intern Emerg Med | 2023 |
Benzodiazepines, Delirium, Emergency department, Mortality, Neuroleptics, Outcome |
Delirium and neuropsychological recovery among emergency general surgery survivors (DANE): study protocol for a randomized controlled trial and collaborative care intervention | Mohanty, S. Holler, E. Ortiz, D. Meagher, A. Perkins, A. Bylund, P. Khan, B. Unverzagt, F. Xu, H. Ingraham, A. Boustani, M. Zarzaur, B. | Trials | 2023 |
Humans |
A randomized, clinical trial investigating the use of a digital intervention to reduce delirium-associated agitation | Nicholas, M. Wittmann, J. Norena, M. Ornowska, M. Reynolds, S. | NPJ Digit Med | 2023 |
delirium, agitation, digital, RASS |
Cognitive Deficits in Executive and Language Functions Predict Postoperative Delirium | Olotu, C. Lebherz, L. Ascone, L. Scherwath, A. Kühn, S. Härter, M. Kiefmann, R. | J Cardiothorac Vasc Anesth | 2023 |
Humans |
Development of post-anesthesia care unit delirium is associated with differences in aperiodic and periodic alpha parameters of the EEG during emergence from general anesthesia - results from a prospective observational cohort study | Ostertag, J. Engelhard, A. Nuttall, R. Aydin, D. Schneider, G. García, P. S. Hinzmann, D. Sleigh, J. W. Kratzer, S. Kreuzer, M. | Anesthesiology | 2023 |
PACU, delirium, EEG, hypnosis, alpha |
Subsyndromal Delirium in Critically Ill Patients-Cognitive and Functional Long-Term Outcomes | Paulino, M. C. Conceição, C. Silvestre, J. Lopes, M. I. Gonçalves, H. Dias, C. C. Serafim, R. Salluh, J. I. F. Póvoa, P. | J Clin Med | 2023 |
Icu, cognitive dysfunction delirium, long-term outcome, subsyndromal delirium |
Prevalence of delirium in gastroenterology/hepatology units: A cross-sectional study | Pazouki, R. Hasselblatt, P. Kugler, C. | Z Gastroenterol | 2023 |
Humans |
Grip Strength is a Predictor for Subsyndromal Delirium Among Older Adults Following Joint Replacement | Qian, J. Shen, X. Gao, X. Sun, Q. | Clin Interv Aging | 2023 |
Aged |
Prevalence and Risk Factors of Delirium in Patients Admitted to Intensive Care Units: A Multicentric Cross-Sectional Study | Sadaf, F. Saqib, M. Iftikhar, M. Ahmad, A. | Cureus | 2023 |
critical illness, delirium, intensive care units, pakistan, prevalence |
Perioperative Factors Associated With Postoperative Delirium in Patients Undergoing Noncardiac Surgery: An Individual Patient Data Meta-Analysis | Sadeghirad, B. Dodsworth, B. T. Schmutz Gelsomino, N. Goettel, N. Spence, J. Buchan, T. A. Crandon, H. N. Baneshi, M. R. Pol, R. A. Brattinga, B. Park, U. J. Terashima, M. Banning, L. B. D. Van Leeuwen, B. L. Neerland, B. E. Chuan, A. Martinez, F. T. Van | JAMA Netw Open | 2023 |
Adult |
Thirty-day mortality among patients with acute delirium in the emergency department | Sanguanwit, P. Ninlamal, S. Prachanukool, T. | Heliyon | 2023 |
30-Day mortality, Delirium, Emergency department, Older-patients |
Role of hypoxia-inducible factor in postoperative delirium of aged patients: A review | Shen, H. Yang, J. Chen, X. Gao, Y. He, B. | Medicine (Baltimore) | 2023 |
Infant, Newborn, Humans, Aged, *Emergence Delirium, Transcription Factors/metabolism, Hypoxia, Ischemia, *Anesthetics, Hypoxia-Inducible Factor 1, alpha Subunit |
The efficacy of earplugs and eye masks for delirium severity and sleep quality in patients undergoing coronary artery bypass grafting in cardiac intensive care units: A single-blind, randomised controlled trial | Shorofi, S. A. Dadashian, P. Arbon, P. Moosazadeh, M. | Aust Crit Care | 2023 |
Coronary artery bypass grafting, Delirium, Earplugs, Eye masks, ICU psychosis, Sleep quality |
Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial | Smit, L. Slooter, A. J. C. Devlin, J. W. Trogrlic, Z. Hunfeld, N. G. M. Osse, R. J. Ponssen, H. H. Brouwers, Ajbw Schoonderbeek, J. F. Simons, K. S. van den Boogaard, M. Lens, J. A. Boer, D. P. Gommers, Dampj Rietdijk, W. J. R. van der Jagt, M. | Crit Care | 2023 |
Adult |
Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial | Smit, L. Slooter, A. J. C. Devlin, J. W. Trogrlic, Z. Hunfeld, N. G. M. Osse, R. J. Ponssen, H. H. Brouwers, Ajbw Schoonderbeek, J. F. Simons, K. S. van den Boogaard, M. Lens, J. A. Boer, D. P. Gommers, Dampj Rietdijk, W. J. R. van der Jagt, M. | Crit Care | 2023 |
Adult |
Effectiveness of a Multi-component Delirium Prevention Program Implemented on General Medicine Hospital Units: an Interrupted Time Series Analysis | Versloot, J. Minotti, S. C. Amer, S. Ali, A. Ma, J. Peters, M. L. Saab, H. Tang, T. Kerr, J. Reid, R. | J Gen Intern Med | 2023 |
Adult, Humans, Aged, Aged, 80 and over, Interrupted Time Series Analysis, Retrospective Studies, *Delirium/diagnosis/epidemiology/prevention & control, Hospitals, Community, Ontario, Hospital Units, delirium prevention, delirium program, inpatients, internal medicine |
Delirium During Critical Illness and Subsequent Change of Treatment in Patients With Cancer: A Mediation Analysis | Vizzacchi, B. A. Dettino, A. L. A. Besen, Bamp Caruso, P. Nassar, A. P., Jr. | Crit Care Med | 2023 |
IUC, delirium, cohort, cancer, CAM |
Efficacy and moderators of prevention and treatment of delirium with melatonin receptor agonists: A systematic review and meta-analysis of randomized controlled trials | Wada, M. Yasuda, H. Nakajima, S. Etani, T. Miura, A. Asada, S. Yoshida, K. Noda, Y. Takeuchi, H. | Gen Hosp Psychiatry | 2023 |
Delirium |
Intraoperative body temperature and emergence delirium in elderly patients after non-cardiac surgery: A secondary analysis of a prospective observational study | Wang, G. He, S. Yu, M. Zhang, Y. Mu, D. Wang, D. | Chin Med J (Engl) | 2023 |
Humans |
Relationship between preoperative neutrophil-to-lymphocyte ratio and postoperative delirium: The PNDABLE and the PNDRFAP cohort studies | Wu, X. Chi, F. Wang, B. Liu, S. Wang, F. Wang, J. Tang, X. Bi, Y. Lin, X. Li, J. | Brain Behav | 2023 |
Alzheimer-related biomarkers |
Risk Factors for Delirium Superimposed on Dementia in Elderly Patients in Comprehensive Ward | Xiao, Q. Zhang, S. Li, C. Zhu, Y. | Am J Alzheimers Dis Other Demen | 2023 |
Humans |
Effect of postoperative delirium after cardiovascular surgery on 5-year mortality | Yokoyama, C. Yoshitnai, K. Ogata, S. Fukushima, S. Matsuda, H. | JA Clin Rep | 2023 |
5-year mortality, Cardiopulmonary bypass, Cardiovascular surgery, Postoperative delirium |
Association Between the Use of Midazolam During Cardiac Anesthesia and the Incidence of Postoperative Delirium: A Retrospective Cohort Study Using a Nationwide Database | Yoshimura, M. Hidaka, Y. Morimoto, Y. | J Cardiothorac Vasc Anesth | 2023 |
Humans, *Emergence Delirium/epidemiology, Midazolam/adverse effects, Retrospective Studies, Incidence, Postoperative Nausea and, Vomiting/chemically induced/epidemiology, *Anesthesia, Cardiac Procedures, Postoperative, Complications/chemically induced/epidemiology, Diagnosis Procedure, Combination data, cardiac surgery, midazolam, postoperative delirium, stabilized inverse probability of treatment |
Associations of Delirium to Posthospital Outcomes After Acute Stroke: A Scoping Review | Young, B. C. Rhoten, B. A. | J Neurosci Nurs | 2023 |
Adult, Humans, Adolescent, *Dexmedetomidine/therapeutic use, Palliative Care, *Pain, Intractable/drug therapy/chemically induced, Hypnotics and, Sedatives/therapeutic use, Retrospective Studies, *Delirium/drug therapy, Intensive Care Units |
Dexmedetomidine use for patients in palliative care with intractable pain and delirium: A retrospective study | Yu, S. Y. Schellenberg, J. Alleyne, A. | PLoS One | 2023 |
Adult, Humans, Adolescent, *Dexmedetomidine/therapeutic use, Palliative Care, *Pain, Intractable/drug therapy/chemically induced, Hypnotics and, Sedatives/therapeutic use, Retrospective Studies, *Delirium/drug therapy, Intensive Care Units |
Validity and predictability of the confusion assessment method for the intensive care unit for delirium among critically ill patients in the intensive care unit: A systematic review and meta-analysis | Zhang, Y. Diao, D. Zhang, H. Gao, Y. | Nurs Crit Care | 2023 |
Cam-icu, critical, delirium, intensive care unit |
Impact of nursing interventions on discharge disposition in patients with postoperative delirium | Zhao, Y. Quon, A. Luke, K. Tivis, L. J. | Nursing | 2023 |
Humans, Aged, Patient Discharge, Retrospective Studies, *Emergence Delirium, *Hypoalbuminemia, Hospitalization |
Causal relationships between delirium and Alzheimer's disease: a bidirectional two-sample Mendelian randomization study | Zheng, J. Du, X. Yang, L. Fu, H. | Eur J Med Res | 2023 |
Humans, *Alzheimer Disease/genetics, Genome-Wide Association Study, Mendelian Randomization Analysis, Risk Factors, Nonoxynol, Alzheimer’s disease, Causal relationships, Delirium, European, Mendelian randomization |
Circadian rhythm disturbance and delirium in ICU patients: a prospective cohort study | Li, J. Cai, S. Liu, X. Mei, J. Pan, W. Zhong, M. Zhang, Y. | Medicine (Baltimore) | 2023 |
United States, Humans, *Hydrocortisone, *Melatonin, Prospective Studies, Circadian Rhythm, Intensive Care Units, Cortisol, Delirium, Melatonin |
Amantadine-associated delirium in patients with maintenance dialysis: Insomnia-associated recovery and uneven seasonal distribution | Li, J. Si, B. Chao, J. He, J. | Medicine (Baltimore) | 2023 |
Humans, Renal Dialysis, Retrospective Studies, Seasons, *Sleep Initiation and Maintenance Disorders/drug therapy, Amantadine/adverse effects, *Delirium/chemically induced/epidemiology |
Effects of Different Injection Rates of Propofol on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Inguinal Hernia Repair | Li, T. Han, W. Yang, X. Wang, Y. Peng, L. He, L. Hu, L. Liu, J. Xia, M. Wang, S. | Drug Des Devel Ther | 2023 |
Humans, Aged, *Propofol/adverse effects, Anesthetics, Intravenous/adverse effects, *Hernia, Inguinal/surgery/chemically induced, Postoperative, Complications/epidemiology, Cognition, *Delirium, *Laparoscopy, bispectral index, burst suppression, elderly, injection rate, postoperative cognitive decline, propofol |
The Effect of Music as a Non-Pharmacological Intervention on the Physiological, Psychological, and Social Response of Patients in an Intensive Care Unit | Lorek, M. Bąk, D. Kwiecień-Jaguś, K. Mędrzycka-Dąbrowska, W. | Healthcare (Basel) | 2023 |
classical music, delirium, intensive care unit, music perception, music therapy, nursing, pain, therapeutic music listening |
Feasibility of a Modified Otago Exercise Program for Older Adults With Cognitive Vulnerability | Mangione, K. K. Darreff, H. Welsh, M. Ni, W. Wolff, E. Booth, J. T. Glenney, S. S. Fortinsky, R. H. | J Appl Gerontol | 2023 |
Humans, Aged, Exercise Therapy, Feasibility Studies, Postural Balance, *Dementia/therapy, Cognition, *Delirium, Otago exercise program, dementia, depression, exercise, feasibility, older adult |
Accuracy of Delirium Screening Tools in Older People with Cancer-A Systematic Review | Martínez-Arnau, F. M. Puchades-García, A. Pérez-Ros, P. | Cancers (Basel) | 2023 |
accuracy, aged, assessment, cancer, delirium, incidence, prevalence, psychometric properties |
Evaluation of the delirium preventive effect of dual orexin receptor antagonist (DORA) in critically ill adult patients requiring ventilation with tracheal intubation at an advanced emergency center: A single-center, retrospective, observational study | Matsuoka, A. Sogawa, R. Murakawa-Hirachi, T. Mizoguchi, Y. Monji, A. Shimanoe, C. Shinada, K. Koami, H. Sakamoto, Y. | J Alzheimers Dis | 2023 |
Humans, Adult, Adolescent, *Orexin Receptor Antagonists/adverse effects, Retrospective Studies, Critical Illness/therapy, *Delirium/prevention & control/epidemiology, Intubation, Intratracheal, Delirium, Intensive care unit, Lemborexant, Sleep disorder, Suvorexant |