What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Effect of electroencephalography-guided anesthetic administration on postoperative delirium among older adults undergoing major surgery the engages randomized clinical trial.
- Authors
- Wildes, T. S. Mickle, A. M. Abdallah, A. B. Maybrier, H. R. Oberhaus, J. Budelier, T. P. Kronzer, A. McKinnon, S. L. Park, D. Torres, B. A. Graetz, T. J. Emmert, D. A. Palanca, B. J. Goswami, S. Jordan, K. Lin, N. Fritz, B. A. Stevens, T. W. Jacobsohn, E.
- Year
- 2019
- Journal
- JAMA
- Abstract
IMPORTANCE Intraoperative electroencephalogram (EEG) waveform suppression, often suggesting excessive general anesthesia, has been associated with postoperative delirium. OBJECTIVE To assess whether EEG-guided anesthetic administration decreases the incidence of postoperative delirium. DESIGN, SETTING, AND PARTICIPANTS Randomized clinical trial of 1232 adults aged60years and older undergoing major surgery and receiving general anesthesia at Barnes-Jewish Hospital in St Louis. Recruitmentwas from January 2015 toMay 2018, with follow-up until July 2018. INTERVENTIONS Patients were randomized 1:1 (stratified by cardiac vs noncardiac surgery and positive vs negative recent fall history) to receive EEG-guided anesthetic administration (n = 614) or usual anesthetic care (n = 618). MAIN OUTCOMES AND MEASURES The primary outcomewas incident delirium during postoperative days 1 through 5. Intraoperative measures included anesthetic concentration, EEG suppression, and hypotension. Adverse events included undesirable intraoperative movement, intraoperative awareness with recall, postoperative nausea and vomiting, medical complications, and death. RESULTS Of the 1232 randomized patients (median age, 69 years [range, 60to 95]; 563women [45.7%]), 1213 (98.5%)were assessed for the primary outcome. Delirium during postoperative days 1 to 5 occurred in 157 of 604patients (26.0%)in the guided group and 140 of 609 patients (23.0%)in the usual care group (difference, 3.0%[95%CI, -2.0%to 8.0%]; P = .22). Median end-tidal volatile anesthetic concentrationwas significantly lower in the guided group than the usual care group (0.69 vs0.80minimum alveolar concentration; difference, -0.11 [95%CI, -0.13 to -0.10), and median cumulative time with EEGsuppressionwas significantly less (7 vs 13 minutes; difference, -6.0[95%CI, -9.9 to -2.1]). Therewas no significant difference between groups in the median cumulative time with mean arterial pressure below60mmHg (7 vs 7 minutes; difference,0.0[95%CI, -1.7 to 1.7]). Undesirablemovement occurred in 137 patients (22.3%) in the guided and 95 (15.4%) in the usual care group.Nopatients reported intraoperative awareness. Postoperative nausea and vomitingwas reported in 48 patients (7.8%) in the guided and 55 patients (8.9%) in the usual care group. Serious adverse eventswere reported in 124 patients (20.2%) in the guided and 130 (21.0%)in the usual care group. Within 30 days of surgery, 4 patients (0.65%) in the guided group and 19 (3.07%) in the usual care group died. CONCLUSIONS AND RELEVANCE Among older adults undergoing major surgery, EEG-guided anesthetic administration, compared with usual care, did not decrease the incidence of postoperative delirium. This finding does not support the use of EEG-guided anesthetic administration for this indication.
- PMID
- Keywords
NCT02241655
NCT02692300
bispectral index monitor
Quatro
anesthetic agent
adult
aged
anesthesia induction
article
awareness
bispectral index
body movement
Confusion Assessment Method
controlled study
double blind procedure
electroencephalography
falling
female
follow up
general anesthesia
heart surgery
human
hypotension
incidence
intermethod comparison
intraoperative period
major clinical study
major surgery
male
mean arterial pressure
mental disease assessment
middle aged
minimum lung alveolus concentration
Missouri
outcome assessment
postoperative complication
postoperative delirium
postoperative nausea and vomiting
postoperative period
priority journal
randomized controlled trial
recall
surgical mortality
very elderly
waveform
- Page(s)
- 473-83
- Volume
- 321
- Issue
- 5
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Validation of the Swedish version of the Nursing Delirium Screening Scale used in patients 70 years and older undergoing cardiac surgery. | Lingehall HC, Smulter N, Engström KG, Gustafson Y, Olofsson B | Journal of clinical nursing | 2013 |
Aged, Aged, 80 and over, Delirium, diagnosis, Female, Humans, Male, Nursing Assessment, Sweden, Thoracic Surgery |
| Perioperative psycho-educational intervention can reduce postoperative delirium in patients after cardiac surgery: a pilot study. | Lee J, Jung J, Noh JS, Yoo S, Hong YS | International journal of psychiatry in medicine | 2013 |
Adult, Aged, Cross-Sectional Studies, Delirium, epidemiology, Empathy, Female, Heart Diseases, psychology, Humans, Intensive Care Units, Internship and Residency, Male, Middle Aged, Patient Education as Topic, methods, Perioperative Care, Physician-Patient Relations, Postoperative Complications, epidemiology, Retrospective Studies, Thoracic Surgery, education, Treatment Outcome |
| Effectiveness of a multi-component intervention to reduce delirium incidence in elderly care wards. | Holt R, Young J, Heseltine D | Age and ageing | 2013 |
Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Aging, Delirium, diagnosis, Emergencies, England, epidemiology, Female, Geriatric Assessment, Geriatrics, Hospital Mortality, Hospital Units, Hospitals, General, Humans, Incidence, Length of Stay, Male, Patient Admission, Patient Discharge, Predictive Value of Tests, Prognosis, Psychiatric Status Rating Scales, Risk Factors, Severity of Illness Index, Time Factors |
| White-matter hyperintensities predict delirium after cardiac surgery. | Hatano Y, Narumoto J, Shibata K, Matsuoka T, Taniguchi S, Hata Y, Yamada K, Yaku H, Fukui K | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2013 | |
| Developing and implementing an integrated delirium prevention system of care: a theory driven, participatory research study. | Godfrey M, Smith J, Green J, Cheater F, Inouye SK, Young JB | BMC health services research | 2013 |
Aged, Community-Based Participatory Research, methods, Delirium, prevention & control, Delivery of Health Care, Integrated, organization & administration, Education, England, Focus Groups, Health Knowledge, Attitudes, Practice, Humans, Interviews as Topic, Models, Organizational, Program Development, State Medicine, organization & administration |
| ICU early mobilization: from recommendation to implementation at three medical centers. | Engel HJ, Needham DM, Morris PE, Gropper MA | Critical care medicine | 2013 |
Academic Medical Centers, Baltimore, Early Ambulation, standards, Humans, Intensive Care, methods, Intensive Care Units, North Carolina, Program Development, Quality Improvement, Retrospective Studies, San Francisco |
| A greater analgesia, sedation, delirium order set quality score is associated with a decreased duration of mechanical ventilation in cardiovascular surgery patients. | Dale CR, Bryson CL, Fan VS, Maynard C, Yanez ND, Treggiari MM | Critical care medicine | 2013 |
Aged, Analgesia, methods, Cardiovascular Surgical Procedures, Clinical Protocols, Critical Illness, Delirium, diagnosis, Female, Humans, Hypnotics and Sedatives, administration & dosage, Intensive Care Units, Male, Middle Aged, Pain, diagnosis, Quality Indicators, Health Care, Quality of Health Care, organization & administration, Respiration, Artificial, methods, Retrospective Studies |
| Onset, risk factors, and impact of delirium in patients with traumatic spinal cord injury. | Cheung A, Thorogood NP, Noonan VK, Zhong Y, Fisher CG, Dvorak MF, Street J | Journal of neurotrauma | 2013 |
Aged, Cohort Studies, Delirium, epidemiology, Female, Humans, Length of Stay, Logistic Models, Male, Middle Aged, Retrospective Studies, Risk Factors, Spinal Cord Injuries, complications |
| The pain, agitation, and delirium care bundle: synergistic benefits of implementing the 2013 Pain, Agitation, and Delirium Guidelines in an integrated and interdisciplinary fashion. | Barr J, Pandharipande PP | Critical care medicine | 2013 |
Adult, Critical Illness, Delirium, drug therapy, Delivery of Health Care, Integrated, Humans, Intensive Care, methods, Intensive Care Units, Interdisciplinary Communication, Outcome Assessment (Health Care), Pain Management, Practice Guidelines as Topic, Psychomotor Agitation, drug therapy |
| Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the Intensive Care Unit: executive summary. | Barr J, Fraser GL, Puntillo K, Ely EW, Gélinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, Coursin DB, Herr DL, Tung A, Robinson BR, Fontaine DK, Ramsay MA, Riker RR, Sessler CN, Pun B, Skrobik Y, Jaeschke R, | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists | 2013 |
Adult, Delirium, diagnosis, Disease Management, Humans, Intensive Care Units, standards, Pain, diagnosis, Pain Management, methods, Psychomotor Agitation, diagnosis |
| Perceptions of nurses and physicians of their communication at night about intensive care patients' pain, agitation, and delirium. | Al-Qadheeb NS, Hoffmeister J, Roberts R, Shanahan K, Garpestad E, Devlin JW | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2013 |
Academic Medical Centers, Analysis of Variance, Communication, Data Collection, Delirium, Factor Analysis, Statistical, Female, Humans, Hypnotics and Sedatives, administration & dosage, Intensive Care Units, organization & administration, Male, Night Care, organization & administration, Pain, Physician-Nurse Relations, Psychomotor Agitation |
| Delirium in the acute phase after stroke and the role of the apolipoprotein E gene. | Oldenbeuving AW, de Kort PL, Kappelle LJ, van Duijn CM, Roks G | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2013 | |
| Consensus and variations in opinions on delirium care: a survey of European delirium specialists. | Morandi A, Davis D, Taylor JK, Bellelli G, Olofsson B, Kreisel S, Teodorczuk A, Kamholz B, Hasemann W, Young J, Agar M, de Rooij SE, Meagher D, Trabucchi M, MacLullich AM | International psychogeriatrics / IPA | 2013 |
Data Collection, Delirium, therapy, Europe, epidemiology, Geriatric Psychiatry, methods, Humans, Practice Guidelines as Topic, standards, Questionnaires |
| Effect of sedation level on the prevalence of delirium when assessed with CAM-ICU and ICDSC. | Haenggi M, Blum S, Brechbuehl R, Brunello A, Jakob SM, Takala J | Intensive care medicine | 2013 |
Aged, Consciousness, drug effects, Delirium, diagnosis, Female, Humans, Hypnotics and Sedatives, administration & dosage, Intensive Care, methods, Intensive Care Units, Male, Mass Screening, methods, Middle Aged, Prevalence, Psychiatric Status Rating Scales |
| Delirium outcomes in a randomized trial of blood transfusion thresholds in hospitalized older adults with hip fracture. | Gruber-Baldini AL, Marcantonio E, Orwig D, Magaziner J, Terrin M, Barr E, Brown JP, Paris B, Zagorin A, Roffey DM, Zakriya K, Blute MR, Hebel JR, Carson JL | Journal of the American Geriatrics Society | 2013 |
Aged, Aged, 80 and over, Blood Transfusion, methods, Delirium, blood, Erythrocyte Transfusion, methods, Female, Hemoglobinometry, Hip Fractures, blood, Hospitalization, Humans, Male, Mental Status Schedule, Neuropsychological Tests, Risk Factors |
| A pilot study to test the feasibility of a nonpharmacologic intervention for the prevention of delirium in the medical intensive care unit. | Foster J, Kelly M | Clinical nurse specialist CNS | 2013 |
Delirium, prevention & control, Feasibility Studies, Female, Humans, Intensive Care Units, Male, Pilot Projects, Prospective Studies, Southwestern United States |
| Delirium superimposed on dementia is associated with prolonged length of stay and poor outcomes in hospitalized older adults. | Fick DM, Steis MR, Waller JL, Inouye SK | Journal of hospital medicine : an official publication of the Society of Hospital Medicine | 2013 |
Aged, Aged, 80 and over, Cohort Studies, Delirium, diagnosis, Dementia, diagnosis, Female, Follow-Up Studies, Hospitalization, trends, Humans, Length of Stay, trends, Male, Prospective Studies, Risk Factors, Treatment Outcome |
| The AWOL tool: derivation and validation of a delirium prediction rule. | Douglas VC, Hessler CS, Dhaliwal G, Betjemann JP, Fukuda KA, Alameddine LR, Lucatorto R, Johnston SC, Josephson SA | Journal of hospital medicine : an official publication of the Society of Hospital Medicine | 2013 |
Aged, Aged, 80 and over, Cohort Studies, Delirium, diagnosis, Female, Follow-Up Studies, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Psychiatric Status Rating Scales, standards, Risk Factors |
| The epidemiology of delirium: challenges and opportunities for population studies. | Davis DH, Kreisel SH, Muniz Terrera G, Hall AJ, Morandi A, Boustani M, Neufeld KJ, Lee HB, Maclullich AM, Brayne C | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2013 |
Cognition Disorders, epidemiology, Data Collection, methods, Delirium, diagnosis, Disease Progression, Humans, Research Design |
| Delirium during acute illness in nursing home residents. | Boockvar K, Signor D, Ramaswamy R, Hung W | Journal of the American Medical Directors Association | 2013 |
Acute Disease, Aged, Cognition Disorders, epidemiology, Delirium, epidemiology, Female, Geriatric Assessment, Humans, Incidence, Male, New York City, epidemiology, Nursing Homes, Prospective Studies, Risk Factors |
| Antipsychotic prescribing patterns, and the factors and outcomes associated with their use, among patients requiring prolonged mechanical ventilation in the long-term acute care hospital setting. | Al-Qadheeb NS, O'Connor HH, White AC, Neidhardt A, Albizati M, Joseph B, Roberts RJ, Ruthazer RR, Devlin JW | The Annals of pharmacotherapy | 2013 |
Adult, Aged, Aged, 80 and over, Antipsychotic Agents, administration & dosage, Benzodiazepines, administration & dosage, Caregivers, Cohort Studies, Delirium, diagnosis, Dibenzothiazepines, administration & dosage, Drug Administration Schedule, Female, Hospitals, Chronic Disease, Humans, Male, Massachusetts, Medical Records, Middle Aged, Patient Participation, Physician’s Practice Patterns, Psychiatric Status Rating Scales, Respiration, Artificial, psychology, Retrospective Studies |
| Pre-existing cerebral infarcts as a risk factor for delirium after coronary artery bypass graft surgery. | Otomo S, Maekawa K, Goto T, Baba T, Yoshitake A | Interactive cardiovascular and thoracic surgery | 2013 |
Aortic Diseases, complications, Atherosclerosis, complications, Cerebral Angiography, Cerebral Infarction, complications, Cognition, Cognition Disorders, complications, Coronary Artery Bypass, adverse effects, Delirium, diagnosis, Female, Humans, Magnetic Resonance Angiography, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Risk Factors, Surgical Procedures, Elective, Ultrasonography, Interventional |
| Delirium after cardiac surgery: incidence and risk factors. | Smulter N, Lingehall HC, Gustafson Y, Olofsson B, Engström KG | Interactive cardiovascular and thoracic surgery | 2013 |
Age Factors, Aged, Aged, 80 and over, Cardiac Surgical Procedures, adverse effects, Delirium, diagnosis, Female, Humans, Incidence, Logistic Models, Male, Multivariate Analysis, Odds Ratio, Psychiatric Status Rating Scales, Risk Factors, Sweden, epidemiology |
| Predictive factors for agitation severity of hyperactive delirium in terminally ill cancer patients in a general hospital using ordered logistic regression analysis. | Kanbayashi Y, Hatano Y, Hata Y, Morita T, Fukui K, Hosokawa T | Journal of palliative medicine | 2013 |
Aged, Anti-Bacterial Agents, therapeutic use, Anti-Inflammatory Agents, Non-Steroidal, therapeutic use, Bilirubin, analysis, Delirium, epidemiology, Female, Hematologic Neoplasms, complications, Hospitals, General, Humans, Japan, epidemiology, Logistic Models, Male, Middle Aged, Predictive Value of Tests, Prevalence, Psychomotor Agitation, epidemiology, Risk Factors, Severity of Illness Index, Sex Factors, Terminally Ill |
| Outcomes of a Geriatric Liaison Intervention to Prevent the Development of Postoperative Delirium in Frail Elderly Cancer Patients: Report on a Multicentre, Randomized, Controlled Trial. | Hempenius L, Slaets JP, van Asselt D, de Bock GH, Wiggers T, van Leeuwen BL | PloS one | 2013 | |
| Care in specialist medical and mental health unit compared with standard care for older people with cognitive impairment admitted to general hospital: randomised controlled trial (NIHR TEAM trial). | Goldberg SE, Bradshaw LE, Kearney FC, Russell C, Whittamore KH, Foster PE, Mamza J, Gladman JR, Jones RG, Lewis SA, Porock D, Harwood RH, | BMJ (Clinical research ed.) | 2013 |
Aged, Aged, 80 and over, Cognition Disorders, therapy, Delirium, therapy, Dementia, therapy, Female, Great Britain, Hospitalization, Hospitals, General, Humans, Length of Stay, Male, Neuropsychological Tests, Outcome Assessment (Health Care), Patient Readmission, Psychiatric Department, Hospital, Quality of Health Care, Quality of Life |
| At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response. | Cunningham C, Maclullich AM | Brain, behavior, and immunity | 2013 |
Adaptation, Physiological, physiology, Animals, Anxiety, complications, Brain, physiopathology, Cognition, physiology, Delirium, etiology, Depression, complications, Humans, Illness Behavior, physiology, Inflammation, complications, Neurodegenerative Diseases, complications, Stress, Physiological, physiology |
| The stress response to surgery and postoperative delirium: evidence of hypothalamic-pituitary-adrenal axis hyperresponsiveness and decreased suppression of the GH/IGF-1 Axis. | Cerejeira J, Batista P, Nogueira V, Vaz-Serra A, Mukaetova-Ladinska EB | Journal of geriatric psychiatry and neurology | 2013 |
Aged, Aged, 80 and over, Anesthesia, Arthroplasty, Replacement, Hip, adverse effects, Cognition, physiology, Data Interpretation, Statistical, Delirium, etiology, Female, Growth Hormone, blood, Humans, Hydrocortisone, blood, Hypothalamo-Hypophyseal System, physiopathology, Immune System, physiology, Inflammation Mediators, blood, Insulin-Like Growth Factor I, physiology, Male, Middle Aged, Neurosecretory Systems, physiology, Perioperative Care, Pituitary-Adrenal System, physiopathology, Postoperative Complications, etiology, Postoperative Period, Stress, Physiological, physiology |
| Do earplugs and eye masks affect sleep and delirium outcomes in the critically ill? | Alway A, Halm MA, Shilhanek M, St Pierre J | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2013 |
Critical Illness, Delirium, prevention & control, Ear Protective Devices, Humans, Intensive Care Units, Masks, Self Report, Sleep Disorders, prevention & control |
| Outcomes of early delirium diagnosis after general anesthesia in the elderly. | Neufeld KJ, Leoutsakos JM, Sieber FE, Wanamaker BL, Gibson Chambers JJ, Rao V, Schretlen DJ, Needham DM | Anesthesia and analgesia | 2013 |
Activities of Daily Living, Aftercare, Age Factors, Aged, Aged, 80 and over, Anesthesia Recovery Period, Anesthesia, General, adverse effects, Baltimore, epidemiology, Cognition, Cognition Disorders, diagnosis, Delirium, diagnosis, Early Diagnosis, Female, Humans, Institutionalization, Linear Models, Logistic Models, Male, Multivariate Analysis, Neuropsychological Tests, Patient Discharge, Patient Transfer, Predictive Value of Tests, Prevalence, Prognosis, Prospective Studies, Psychiatric Status Rating Scales, Recovery Room, Risk Factors, Time Factors |
| An enhanced exercise and cognitive programme does not appear to reduce incident delirium in hospitalised patients: a randomised controlled trial. | Jeffs KJ, Berlowitz DJ, Grant S, Lawlor V, Graco M, de Morton NA, Savige JA, Lim WK | BMJ open | 2013 | |
| BIS-guided anesthesia decreases postoperative delirium and cognitive decline. | Chan MT, Cheng BC, Lee TM, Gin T, | Journal of neurosurgical anesthesiology | 2013 |
Aged, Anesthesia, General, adverse effects, Asian Continental Ancestry Group, Cognition Disorders, etiology, Color Perception, physiology, Consciousness Monitors, Delirium, etiology, Female, Humans, Male, Neuropsychological Tests, Postoperative Complications, prevention & control, Prospective Studies, Risk Factors, Treatment Outcome, Verbal Behavior, Verbal Learning |
| Investigating polypharmacy and drug burden index in hospitalised older people. | Best O, Gnjidic D, Hilmer SN, Naganathan V, McLachlan AJ | Internal medicine journal | 2013 |
Age Factors, Aged, Aged, 80 and over, Cholinergic Antagonists, administration & dosage, Cohort Studies, Delirium, chemically induced, Female, Hospitalization, trends, Humans, Hypnotics and Sedatives, administration & dosage, Male, New South Wales, epidemiology, Polypharmacy, Retrospective Studies |
| Corticosteroids and transition to delirium in patients with acute lung injury. | Schreiber MP, Colantuoni E, Bienvenu OJ, Neufeld KJ, Chen KF, Shanholtz C, Mendez-Tellez PA, Needham DM | Critical care medicine | 2014 |
APACHE, Acute Lung Injury, complications, Adrenal Cortex Hormones, administration & dosage, Adult, Age Factors, Critical Illness, therapy, Delirium, diagnosis, Female, Humans, Intensive Care Units, Male, Markov Chains, Middle Aged, Organ Dysfunction Scores, Prospective Studies, Respiration, Artificial, Risk Factors, Severity of Illness Index, Treatment Outcome |
| Interprofessional education for delirium care: a systematic review. | Sockalingam S, Tan A, Hawa R, Pollex H, Abbey S, Hodges BD | Journal of interprofessional care | 2014 | |
| Delirium, a Symptom of UTI in the Elderly: Fact or Fable? A Systematic Review. | Balogun SA, Philbrick JT | Canadian geriatrics journal : CGJ | 2014 | |
| Improved analgesia, sedation, and delirium protocol associated with decreased duration of delirium and mechanical ventilation. | Dale CR, Kannas DA, Fan VS, Daniel SL, Deem S, Yanez ND, Hough CL, Dellit TH, Treggiari MM | Annals of the American Thoracic Society | 2014 | |
| Race and documentation of cognitive impairment in hospitalized older adults. | Campbell NL, Cantor BB, Hui SL, Perkins A, Khan BA, Farber MO, Nazir A, Garrett SL, Ely EW, Boustani MA | Journal of the American Geriatrics Society | 2014 |
Aged, Cognition, Cognition Disorders, diagnosis, Continental Population Groups, Female, Geriatric Assessment, methods, Health Records, Personal, Humans, Indiana, epidemiology, Inpatients, statistics & numerical data, Male, Mental Status Schedule, Prevalence, Questionnaires, Retrospective Studies, Risk Factors, Urban Population |
| Delirium in the cardiac surgical ICU. | Brown CH | Current opinion in anaesthesiology | 2014 | |
| Postoperative delirium in Parkinson's disease patients following deep brain stimulation surgery. | Carlson JD, Neumiller JJ, Swain LD, Mark J, McLeod P, Hirschauer J | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | 2014 | |
| Prospective observational study of dementia in older patients admitted to acute hospitals. | Travers C, Byrne GJ, Pachana NA, Klein K, Gray LC | Australasian journal on ageing | 2014 | |
| Do patients of delirium have catatonic features? An exploratory study. | Grover S, Ghosh A, Ghormode D | Psychiatry and clinical neurosciences | 2014 | |
| Frequency and factors associated with falls in patients with advanced cancer presenting to an outpatient supportive care clinic. | Kuriya M, Yennurajalingam S, de la Cruz MG, Wei W, Palla S, Bruera E | Palliative & supportive care | 2015 | |
| Impact of anticholinergic discontinuation on cognitive outcomes in older people: a systematic review. | Salahudeen MS, Duffull SB, Nishtala PS | Drugs & aging | 2014 | |
| Patient frailty: the elephant in the operating room. | Hubbard RE, Story DA | Anaesthesia | 2014 |
Aged, Aged, 80 and over, Frail Elderly, statistics & numerical data, Geriatric Assessment, methods, Humans, Inpatients, statistics & numerical data, Risk Assessment, Risk Factors, Surgical Procedures, Operative |
| Should general anaesthesia be avoided in the elderly? | Strøm C, Rasmussen LS, Sieber FE | Anaesthesia | 2014 |
Aged, Aged, 80 and over, Anesthesia, General, adverse effects, Cognition Disorders, chemically induced, Delirium, chemically induced, Geriatric Assessment, methods, Humans, Postoperative Complications, chemically induced, Risk Factors |
| Cognitive interviews guide design of a new CAM patient expectations questionnaire. | Sherman KJ, Eaves ER, Ritenbaugh C, Hsu C, Cherkin DC, Turner JA | BMC complementary and alternative medicine | 2014 | |
| The association between C-reactive protein and delirium in 710 acute elderly hospital admissions. | Ritchie CW, Newman TH, Leurent B, Sampson EL | International psychogeriatrics / IPA | 2014 |
Acute Disease, Aged, Biological Markers, analysis, C-Reactive Protein, analysis, Cardiovascular Diseases, complications, Confusion, diagnosis, Delirium, blood, Female, Geriatric Assessment, methods, Hospitalization, statistics & numerical data, Humans, Infection, complications, London, Male, Musculoskeletal Diseases, complications, Neurologic Examination, methods, Prospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Statistics as Topic |
| The impact of acute brain dysfunction in the outcomes of mechanically ventilated cancer patients. | Almeida IC, Soares M, Bozza FA, Shinotsuka CR, Bujokas R, Souza-Dantas VC, Ely EW, Salluh JI | PloS one | 2014 | |
| Sedation and delirium in the intensive care unit. | Reade MC, Finfer S | The New England journal of medicine | 2014 |
Algorithms, Analgesics, adverse effects, Delirium, drug therapy, Humans, Hypnotics and Sedatives, administration & dosage, Intensive Care Units, Pain, complications, Postoperative Care, adverse effects, Postoperative Complications, drug therapy, Respiration, Artificial |
| New consciousness scale for delirium. | Neerland BE, Ahmed M, Watne LO, Hov KR, Wyller TB | Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række | 2014 |
Confusion, classification, Consciousness, classification, Delirium, classification, Humans, Norway, Observation, Severity of Illness Index, Translations |
| Missing link or not, mobilise against delirium. | Page VJ, Casarin A | Critical care (London, England) | 2014 | |
| Postoperative delirium in a substudy of cardiothoracic surgical patients in the BAG-RECALL clinical trial. | Whitlock EL, Torres BA, Lin N, Helsten DL, Nadelson MR, Mashour GA, Avidan MS | Anesthesia and analgesia | 2014 |
Aged, Anesthesia, General, Anesthetics, pharmacokinetics, Bayes Theorem, Cardiac Surgical Procedures, adverse effects, Confidence Intervals, Confusion, chemically induced, Consciousness Monitors, Delirium, etiology, Female, Humans, Intraoperative Period, Length of Stay, Logistic Models, Male, Middle Aged, Neuropsychological Tests, Postoperative Complications, psychology, Predictive Value of Tests, Thoracic Surgical Procedures, adverse effects, Treatment Outcome |
| Statin use and risk of delirium in the critically ill. | Page VJ, Davis D, Zhao XB, Norton S, Casarin A, Brown T, Ely EW, McAuley DF | American journal of respiratory and critical care medicine | 2014 |
Adult, Aged, Aged, 80 and over, Biological Markers, blood, C-Reactive Protein, metabolism, Critical Care, methods, Delirium, blood, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, therapeutic use, Intensive Care Units, Linear Models, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Outcome Assessment (Health Care), Propensity Score, Prospective Studies, Risk Factors |
| A relational ethical approach to end-of-life delirium. | Wright DK, Brajtman S, Macdonald ME | Journal of pain and symptom management | 2014 | |
| Rapidly reversible, sedation-related delirium versus persistent delirium in the intensive care unit. | Patel SB, Poston JT, Pohlman A, Hall JB, Kress JP | American journal of respiratory and critical care medicine | 2014 |
Adolescent, Adult, Aged, Aged, 80 and over, Conscious Sedation, adverse effects, Delirium, chemically induced, Female, Fentanyl, adverse effects, Follow-Up Studies, Humans, Hypnotics and Sedatives, adverse effects, Intensive Care, methods, Intensive Care Units, Length of Stay, statistics & numerical data, Logistic Models, Male, Middle Aged, Outcome Assessment (Health Care), Prognosis, Propofol, adverse effects, Proportional Hazards Models, Prospective Studies, Respiration, Artificial, statistics & numerical data, Single-Blind Method, Young Adult |
| Management of pain, agitation, and delirium in critically ill patients. | Pandharipande PP, Patel MB, Barr J | Polskie Archiwum Medycyny Wewnętrznej | 2014 | |
| Care and Respect for Elders in Emergencies program: a preliminary report of a volunteer approach to enhance care in the emergency department. | Sanon M, Baumlin KM, Kaplan SS, Grudzen CR | Journal of the American Geriatrics Society | 2014 |
Activities of Daily Living, Aged, Emergencies, Emergency Service, Hospital, standards, Female, Humans, Male, Patient Care Team, standards, Program Development, methods, Quality Improvement, Quality of Life, Retrospective Studies, Volunteers |
| Concordance between DSM-IV and DSM-5 criteria for delirium diagnosis in a pooled database of 768 prospectively evaluated patients using the delirium rating scale-revised-98. | Meagher DJ, Morandi A, Inouye SK, Ely W, Adamis D, Maclullich AJ, Rudolph JL, Neufeld K, Leonard M, Bellelli G, Davis D, Teodorczuk A, Kriesel S, Thomas C, Hasemann W, Timmons S, O Regan N, Grover S, Jabbar F, Cullen W, Dunne C, Kamholz B, Van Munster BC, | BMC medicine | 2014 | |
| Perioperative cognitive trajectory in adults. | Nadelson MR, Sanders RD, Avidan MS | British journal of anaesthesia | 2014 |
Affect, Cognition, physiology, Cognition Disorders, epidemiology, Critical Illness, Delirium, epidemiology, Dementia, epidemiology, Humans, Inflammation, psychology, Pain, Postoperative, epidemiology, Perioperative Period, psychology, Postoperative Complications, genetics, Quality of Life, Research |
| Underrepresentation of patients with pre-existing cognitive impairment in pharmaceutical trials on prophylactic or therapeutic treatments for delirium: a systematic review. | de Jonghe A, van de Glind EM, van Munster BC, de Rooij SE | Journal of psychosomatic research | 2014 | |
| Haloperidol prophylaxis does not prevent postoperative delirium in elderly patients: a randomized, open-label prospective trial. | Fukata S, Kawabata Y, Fujisiro K, Katagawa Y, Kuroiwa K, Akiyama H, Terabe Y, Ando M, Kawamura T, Hattori H | Surgery today | 2014 | |
| Transcranial Doppler to measure cerebral blood flow in delirium superimposed on dementia. A cohort study. | Caplan GA, Lan Z, Newton L, Kvelde T, McVeigh C, Hill MA | Journal of the American Medical Directors Association | 2014 | |
| Increasing anticholinergic burden and delirium in palliative care inpatients. | Zimmerman KM, Salow M, Skarf LM, Kostas T, Paquin A, Simone MJ, Rudolph J | Palliative medicine | 2014 | |
| Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial. | Hatta K, Kishi Y, Wada K, Takeuchi T, Odawara T, Usui C, Nakamura H, | JAMA psychiatry | 2014 |
Aged, Aged, 80 and over, Alzheimer Disease, diagnosis, Delirium, diagnosis, Female, Hospitals, General, Hospitals, University, Humans, Indenes, adverse effects, Kaplan-Meier Estimate, Male, Risk, Single-Blind Method |
| Delirium, agitation, and symptom distress within the final seven days of life among cancer patients receiving hospice care. | de la Cruz M, Noguera A, San Miguel-Arregui MT, Williams J, Chisholm G, Bruera E | Palliative & supportive care | 2015 |
Aged, Aged, 80 and over, Delirium, epidemiology, Female, Home Nursing, Hospice Care, Humans, Male, Middle Aged, Neoplasms, nursing, Predictive Value of Tests, Psychomotor Agitation, epidemiology, Retrospective Studies, Sensitivity and Specificity, Severity of Illness Index, Stress, Psychological, epidemiology, Surveys and Questionnaires, Terminal Care |
| Randomized ICU trials do not demonstrate an association between interventions that reduce delirium duration and short-term mortality: a systematic review and meta-analysis. | Al-Qadheeb NS, Balk EM, Fraser GL, Skrobik Y, Riker RR, Kress JP, Whitehead S, Devlin JW | Critical care medicine | 2014 |
Delirium, mortality, Intensive Care Units, Time Factors |
| Delirium detection based on monitoring of blinks and eye movements. | van der Kooi AW, Rots ML, Huiskamp G, Klijn FA, Koek HL, Kluin J, Leijten FS, Slooter AJ | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2014 | |
| Do patient characteristics influence nursing adherence to a guideline for preventing delirium? | Ijkema R, Langelaan M, van de Steeg L, Wagner C | Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing / Sigma Theta Tau | 2014 |
Aged, Aged, 80 and over, Delirium, nursing, Female, Guideline Adherence, statistics & numerical data, Humans, Male, Mass Screening, nursing, Medical Records, Nursing Evaluation Research, Patients, statistics & numerical data, Practice Guidelines as Topic, Retrospective Studies, Risk Assessment |
| Burden in caregivers of cognitively impaired elderly adults at time of hospitalization: a cross-sectional analysis. | Shankar KN, Hirschman KB, Hanlon AL, Naylor MD | Journal of the American Geriatrics Society | 2014 |
Activities of Daily Living, Adaptation, Psychological, Adolescent, Adult, Aged, Aged, 80 and over, Burnout, Professional, epidemiology, Caregivers, psychology, Cognition Disorders, nursing, Cross-Sectional Studies, Female, Humans, Incidence, Male, Middle Aged, United States, epidemiology, Young Adult |
| Recalibration of the delirium prediction model for ICU patients (PRE-DELIRIC): a multinational observational study. | van den Boogaard M, Schoonhoven L, Maseda E, Plowright C, Jones C, Luetz A, Sackey PV, Jorens PG, Aitken LM, van Haren FM, Donders R, van der Hoeven JG, Pickkers P | Intensive care medicine | 2014 | |
| UK medical teaching about ageing is improving but there is still work to be done: the Second National Survey of Undergraduate Teaching in Ageing and Geriatric Medicine. | Gordon AL, Blundell A, Dhesi JK, Forrester-Paton C, Forrester-Paton J, Mitchell HK, Bracewell N, Mjojo J, Masud T, Gladman JR | Age and ageing | 2014 | |
| Prevalence of frailty and its ability to predict in hospital delirium, falls, and 6-month mortality in hospitalized older patients. | Joosten E, Demuynck M, Detroyer E, Milisen K | BMC geriatrics | 2014 |
Accidental Falls, mortality, Aged, Aged, 80 and over, Delirium, diagnosis, Female, Frail Elderly, Geriatric Assessment, methods, Hospitalization, trends, Humans, Male, Predictive Value of Tests, Prevalence, Prospective Studies, Risk Factors |
| Delirium knowledge and recognition: a randomized controlled trial of a web-based educational intervention for acute care nurses. | McCrow J, Sullivan KA, Beattie ER | Nurse education today | 2014 | |
| A standardized, bundled approach to providing geriatric-focused acute care. | Mattison ML, Catic A, Davis RB, Olveczky D, Moran J, Yang J, Aronson M, Zeidel M, Lipsitz L, Marcantonio ER | Journal of the American Geriatrics Society | 2014 |
Academic Medical Centers, statistics & numerical data, Administration, Oral, Aged, Aged, 80 and over, Decision Support Techniques, Delirium, diagnosis, Delivery of Health Care, standards, Dose-Response Relationship, Drug, Female, Geriatric Assessment, Geriatrics, methods, Haloperidol, administration & dosage, Hospitalization, trends, Humans, Injections, Intramuscular, Injections, Intravenous, Male, Massachusetts, epidemiology, Mental Status Schedule, Morphine, administration & dosage, Prevalence, Prognosis, Retrospective Studies, Time Factors |
| Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people. | Bellelli G, Morandi A, Davis DH, Mazzola P, Turco R, Gentile S, Ryan T, Cash H, Guerini F, Torpilliesi T, Del Santo F, Trabucchi M, Annoni G, MacLullich AM | Age and ageing | 2014 | |
| Delirium superimposed on dementia strongly predicts worse outcomes in older rehabilitation inpatients. | Morandi A, Davis D, Fick DM, Turco R, Boustani M, Lucchi E, Guerini F, Morghen S, Torpilliesi T, Gentile S, MacLullich AM, Trabucchi M, Bellelli G | Journal of the American Medical Directors Association | 2014 | |
| Objective assessment of attention in delirium: a narrative review. | Tieges Z, Brown LJ, Maclullich AM | International journal of geriatric psychiatry | 2014 | |
| Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium. | Davis DH, Skelly DT, Murray C, Hennessy E, Bowen J, Norton S, Brayne C, Rahkonen T, Sulkava R, Sanderson DJ, Rawlins JN, Bannerman DM, MacLullich AM, Cunningham C | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2015 | |
| Ethical challenges and solutions regarding delirium studies in palliative care. | Sweet L, Adamis D, Meagher DJ, Davis D, Currow DC, Bush SH, Barnes C, Hartwick M, Agar M, Simon J, Breitbart W, MacDonald N, Lawlor PG | Journal of pain and symptom management | 2014 | |
| Development of an abbreviated version of the delirium motor subtyping scale (DMSS-4). | Meagher D, Adamis D, Leonard M, Trzepacz P, Grover S, Jabbar F, Meehan K, O'Connor M, Cronin C, Reynolds P, Fitzgerald J, O'Regan N, Timmons S, Slor C, de Jonghe J, de Jonghe A, van Munster BC, de Rooij SE, Maclullich A | International psychogeriatrics / IPA | 2014 | |
| Treating an established episode of delirium in palliative care: expert opinion and review of the current evidence base with recommendations for future development. | Bush SH, Kanji S, Pereira JL, Davis DH, Currow DC, Meagher DJ, Rabheru K, Wright DK, Bruera E, Agar M, Hartwick M, Gagnon PR, Gagnon B, Breitbart W, Regnier L, Lawlor PG | Journal of pain and symptom management | 2014 | |
| Attention! A good bedside test for delirium? | O'Regan NA, Ryan DJ, Boland E, Connolly W, McGlade C, Leonard M, Clare J, Eustace JA, Meagher D, Timmons S | Journal of neurology, neurosurgery, and psychiatry | 2014 |
Adolescent, Adult, Aged, Aged, 80 and over, Attention, Confusion, diagnosis, Cross-Sectional Studies, Delirium, diagnosis, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Psychological Techniques, instrumentation, Sensitivity and Specificity, Young Adult |
| An analytical framework for delirium research in palliative care settings: integrated epidemiologic, clinician-researcher, and knowledge user perspectives. | Lawlor PG, Davis DH, Ansari M, Hosie A, Kanji S, Momoli F, Bush SH, Watanabe S, Currow DC, Gagnon B, Agar M, Bruera E, Meagher DJ, de Rooij SE, Adamis D, Caraceni A, Marchington K, Stewart DJ | Journal of pain and symptom management | 2014 | |
| Practical assessment of delirium in palliative care. | Leonard MM, Nekolaichuk C, Meagher DJ, Barnes C, Gaudreau JD, Watanabe S, Agar M, Bush SH, Lawlor PG | Journal of pain and symptom management | 2014 | |
| Delirium diagnostic and classification challenges in palliative care: subsyndromal delirium, comorbid delirium-dementia, and psychomotor subtypes. | Leonard MM, Agar M, Spiller JA, Davis B, Mohamad MM, Meagher DJ, Lawlor PG | Journal of pain and symptom management | 2014 | |
| End-of-life delirium: issues regarding recognition, optimal management, and the role of sedation in the dying phase. | Bush SH, Leonard MM, Agar M, Spiller JA, Hosie A, Wright DK, Meagher DJ, Currow DC, Bruera E, Lawlor PG | Journal of pain and symptom management | 2014 | |
| A comparison of the revised Delirium Rating Scale (DRS-R98) and the Memorial Delirium Assessment Scale (MDAS) in a palliative care cohort with DSM-IV delirium. | O'Sullivan R, Meagher D, Leonard M, Watne LO, Hall RJ, Maclullich AM, Trzepacz P, Adamis D | Palliative & supportive care | 2015 | |
| The descriptive epidemiology of delirium symptoms in a large population-based cohort study: results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). | Davis DH, Barnes LE, Stephan BC, MacLullich AM, Meagher D, Copeland J, Matthews FE, Brayne C, | BMC geriatrics | 2014 | |
| Phenomenological and biological correlates of improved cognitive function in hospitalized elderly medical inpatients. | Adamis D, Meagher D, Treloar A, Dunne C, Larvin M, Martin FC, Macdonald AJ | Archives of gerontology and geriatrics | 2014 | |
| Delirium during psychiatric admission increases mortality in psychiatric patients during and after hospitalization. A nationwide study from 1995 through 2012. | Lundberg AS, Gustafsson LN, Meagher D, Munk-Jørgensen P | Journal of psychosomatic research | 2014 | |
| The CareWell in Hospital program to improve the quality of care for frail elderly inpatients: results of a before-after study with focus on surgical patients. | Bakker FC, Persoon A, Bredie SJ, van Haren-Willems J, Leferink VJ, Noyez L, Schoon Y, Olde Rikkert MG | American journal of surgery | 2014 | |
| Outcomes of an innovative model of acute delirium care: the Geriatric Monitoring Unit (GMU). | Chong MS, Chan M, Tay L, Ding YY | Clinical interventions in aging | 2014 | |
| Delirium in elderly people--authors'reply. | Inouye SK, Westendorp RG, Saczynski JS, Kimchi EY, Cleinman AA | Lancet | 2014 |
Delirium, diagnosis, Humans |
| Delirium risk prediction, healthcare use and mortality of elderly adults in the emergency department. | Kennedy M, Enander RA, Tadiri SP, Wolfe RE, Shapiro NI, Marcantonio ER | Journal of the American Geriatrics Society | 2014 |
Aged, Aged, 80 and over, Delirium, complications, Delivery of Health Care, utilization, Emergency Service, Hospital, Female, Follow-Up Studies, Geriatric Assessment, methods, Humans, Incidence, Length of Stay, trends, Male, Massachusetts, epidemiology, Mental Status Schedule, Prospective Studies, Risk Factors, Stroke, complications, Survival Rate, trends |
| Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium. | Xie Z, Swain CA, Ward SA, Zheng H, Dong Y, Sunder N, Burke DW, Escobar D, Zhang Y, Marcantonio ER | Annals of clinical and translational neurology | 2014 | |
| Calibration and validation of an innovative approach for estimating general cognitive performance. | Gross AL, Jones RN, Fong TG, Tommet D, Inouye SK | Neuroepidemiology | 2014 | |
| The modified Hospital Elder Life Program: adapting a complex intervention for feasibility and scalability in a surgical setting. | Chen CC, Saczynski J, Inouye SK | Journal of gerontological nursing | 2014 |
Aged, Evidence-Based Practice, Feasibility Studies, Health Services for the Aged, organization & administration, Hospitals, Humans, Surgical Procedures, Operative |
| NICE to HELP: operationalizing National Institute for Health and Clinical Excellence guidelines to improve clinical practice. | Yue J, Tabloski P, Dowal SL, Puelle MR, Nandan R, Inouye SK | Journal of the American Geriatrics Society | 2014 |
Aged, 80 and over, Delirium, diagnosis, Delivery of Health Care, standards, Geriatrics, standards, Great Britain, epidemiology, Humans, Practice Guidelines as Topic, Prevalence |
| Delirium diagnosis methodology used in research: a survey-based study. | Neufeld KJ, Nelliot A, Inouye SK, Ely EW, Bienvenu OJ, Lee HB, Needham DM | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2014 |